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HIST1H2BK Gene

protein-coding   GIFtS: 53
GCID: GC06M027105

Histone Cluster 1, H2bk

(Previous names: H2B histone family, member T, histone 1, H2bk)
(Previous symbol: H2BFT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H2bk1 2     H2BK2 5
H2BFT1 2 3     H2B/S2
H2B Histone Family, Member T1 2     H2BFAiii2
Histone 1, H2bk1 2     Histone Family Member2
H2B K2 3     Histone H2B Type 1-K2
HIRA-Interacting Protein 12 3     HIRIP13

External Ids:    HGNC: 139541   Entrez Gene: 852362   Ensembl: ENSG000001979037   OMIM: 6150455   UniProtKB: O608143   

Export aliases for HIST1H2BK gene to outside databases

Previous GC identifers: GC06M027163 GC06M027214 GC06M026914


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H2BK Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on
chromosome 6p21.33. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2BK Gene:
HIST1H2BK (histone cluster 1, H2bk) is a protein-coding gene. Diseases associated with HIST1H2BK include systemic lupus erythematosus, and hiv-1. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot: H2B1K_HUMAN, O60814
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling
Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST1H2BK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H2BK gene promoter:
         Pax-5   HTF   XBP-1   MIF-1   Cdc5   Max   PPAR-alpha   FOXO4   ZID   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2BK promoter sequence
   Search Chromatin IP Primers for HIST1H2BK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2BK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2BK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027105:  view genomic region     (about GC identifiers)

Start:
27,106,072 bp from pter      End:
27,114,637 bp from pter
Size:
8,566 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H2B1K_HUMAN, O60814 (See protein sequence)
Recommended Name: Histone H2B type 1-K  
Size: 126 amino acids; 13890 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
1 PDB 3D structure from and Proteopedia for HIST1H2BK:
2CV5 (3D)    
Secondary accessions: A8K7P7 Q2VPI7

Explore the universe of human proteins at neXtProt for HIST1H2BK: NX_O60814

Explore proteomics data for HIST1H2BK at MOPED

Post-translational modifications: 

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as
    a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a
    large set of exons1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys6, Lys44, Lys47, Lys58, Lys109, Lys117, Lys121
  • Glycosylation2 at Ser113
  • Modification sites at PhosphoSitePlus

  • See HIST1H2BK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542160.1  
    ENSEMBL proteins: 
     ENSP00000349430   ENSP00000380100  
    Reactome Protein details: O60814

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry O60814

    ProtoNet protein and cluster: O60814

    UniProtKB/Swiss-Prot: H2B1K_HUMAN, O60814
    Similarity: Belongs to the histone H2B family


    HIST1H2BK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B1K_HUMAN, O60814
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling
    Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
    barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    HIST1H2BK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HIST1H2BK:
     Increased G2M DNA content  Increased TP53 protein express 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target HIST1H2BK:
    hsa-mir-138-5p (MIRT045835), hsa-mir-320a (MIRT044421), hsa-mir-98-5p (MIRT027811), hsa-mir-324-3p (MIRT042857), hsa-mir-424-5p (MIRT042437), hsa-mir-16-5p (MIRT051151), hsa-mir-1180-3p (MIRT035923), hsa-mir-423-5p (MIRT038110), hsa-mir-1292-5p (MIRT035830), hsa-mir-31-5p (MIRT049866), hsa-mir-186-5p (MIRT045125), hsa-mir-15a-5p (MIRT051316)

    Block miRNA regulation of human, mouse, rat HIST1H2BK using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2B1K_HUMAN, O60814: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    HIST1H2BK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H2BK About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Chromosome Maintenance0.62
    Meiotic Synapsis0.66
    Nucleosome assembly0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Telomere Maintenance0.64
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    Selected Reactome Pathways for HIST1H2BK (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST1H2BK):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H2BK for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H2BK
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H2BK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H2BK (O608143 ENSP000003494304) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628053, ENSP000003665814I2D: score=3 STRING: ENSP00000366581
    HIST1H4CP628053, ENSP000003670344I2D: score=3 STRING: ENSP00000367034
    HIST1H4DP628053, ENSP000003432824I2D: score=3 STRING: ENSP00000343282
    HIST1H4EP628053, ENSP000003536244I2D: score=3 STRING: ENSP00000353624
    HIST1H4HP628053, ENSP000002893524I2D: score=3 STRING: ENSP00000289352
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006334nucleosome assembly IEA--
    GO:0042742defense response to bacterium IEA--

    HIST1H2BK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H2BK (H2B1K)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H2BK gene: 
    NM_080593.2  

    Unigene Cluster for HIST1H2BK:

    Histone cluster 1, H2bk
    Hs.437275  [show with all ESTs]
    Unigene Representative Sequence: BU500887
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356950(uc021yoy.1) ENST00000396891(uc003nix.2)
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    Additional mRNA sequence: 

    AJ223352.1 BC000893.1 BC051872.1 BC064959.1 BC108737.1 

    13 DOTS entries:

    DT.446772  DT.121132662  DT.100867360  DT.95189458  DT.97801811  DT.92452704  DT.120840204  DT.100652612 
    DT.121354589  DT.95189456  DT.95189461  DT.80100210  DT.91892031 

    Selected AceView cDNA sequences (see all 253):

    AI138510 AW879006 AI318046 CB117238 BM762777 AW404382 NM_080593 BX094548 
    BE887761 BM711548 AW951982 BC051872 BQ128232 CF129187 BM991442 BQ945730 
    BM839785 CD367886 BE622317 BU618944 BG113317 BU632005 CF130147 CB995556 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H2BK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCCTTCG
    HIST1H2BK Expression
    About this image


    HIST1H2BK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    HIST1H2BK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H2BK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437275
        Custom PCR Arrays for HIST1H2BK
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2BK gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2bk1 , 5 histone cluster 1, H2bk1, 5 92.06(n)1
    99.21(a)1
      13 (8.14 cM)5
    3191841  NM_175665.11  NP_783596.11 
     220358705 
    soybean
    (Glycine max)
    eudicotyledons 445112582   -- 81.35(n)  
    rice
    (Oryza sativa)
    Liliopsida AU029435.12   -- 82.08(n)    AU029435.1 


    ENSEMBL Gene Tree for HIST1H2BK (if available)
    TreeFam Gene Tree for HIST1H2BK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H2BK gene
    HIST1H2BN2  HIST1H2BD2  HIST1H2BC2  HIST1H2BE2  HIST1H2BB2  HIST1H2BM2  HIST3H2BB2  HIST1H2BI2  
    HIST1H2BG2  HIST2H2BF2  HIST1H2BH2  HIST1H2BL2  HIST1H2BO2  HIST1H2BJ2  HIST1H2BF2  HIST2H2BE2  
    Selected SIMAP similar genes for HIST1H2BK using alignment to 1 protein entry:     H2B1K_HUMAN(see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH
    HIST1H2BI    HIST1H2BJ    HIST1H2BM    HIST1H2BN    HIST1H2BO    HIST2H2BE
    HIST2H2BF    HIST3H2BB    HIST1H2BC    H2BFS    HIST1H2BL    ABCF2

    HIST1H2BK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H2BK (see all 109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737396001,2
    C,F--27107998(+) TGGTGG/ACCACA 1 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs168942411,2
    C,F--27108197(+) TTGCTC/GTTGAA 1 -- int16Minor allele frequency- G:0.03NA WA CSA 264
    rs1416288001,2
    --27108211(+) TATCCA/GTGTTG 1 -- int10--------
    rs2014649371,2
    --27108294(+) CTCTG-/TTGA  
            
    TTTTT
    1 -- int10--------
    rs1509161871,2
    --27108336(+) CAGCTC/GTGCAT 1 -- int10--------
    rs1385308891,2
    --27108603(+) GATTTA/GATTTG 1 -- int10--------
    rs39991051,2
    C--27108811(+) GAGCTA/GCAGGC 1 -- int11Minor allele frequency- G:0.00NA 2
    rs1897343621,2
    --27108819(+) GGCATC/TAATCT 1 -- int10--------
    rs1926921701,2
    --27108939(+) GCTAAC/GGGAAG 1 -- int10--------
    rs1839639881,2
    --27109147(+) TTACTC/GTTATT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HIST1H2BK (27106072 - 27114637 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HIST1H2BK: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2BK
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2BK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615045    OMIM disorders: --

    3 diseases for HIST1H2BK:    
    About MalaCards
    systemic lupus erythematosus    hiv-1    lupus erythematosus


    HIST1H2BK for disorders           About GeneDecksing


    Export disorders for HIST1H2BK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H2BK gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with HIST1H2BK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (Cell 2006)
    3. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (Mol. Cell. Proteomics 2006)
    4. Gene-specific characterization of human histone H2B by electron capture dissociation. (PubMed id 16457587)1, 2 Siuti N.... Pesavento J.J. (J. Proteome Res. 2006)
    5. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (Mol. Cell. Biochem. 2005)
    6. Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle. (PubMed id 15951514)1, 2 Tsunaka Y.... Morikawa K. (Nucleic Acids Res. 2005)
    7. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (Mol. Cell 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Antimicrobial peptides in the first line defence of human colon mucosa. (PubMed id 12860195)1, 2 Tollin M....Agerberth B. (Peptides 2003)
    10. Antimicrobial polypeptides of the human colonic epithelium. (PubMed id 15019208)1, 2 Howell S.J.... Bevins C.L. (Peptides 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85236 HGNC: 13954 AceView: HIST1H2BJandHIST1H2BK Ensembl:ENSG00000197903 euGenes: HUgn85236
    ECgene: HIST1H2BK Kegg: 85236 H-InvDB: HIST1H2BK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H2BK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H2BK gene:
    Search GeneIP for patents involving HIST1H2BK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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