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Aliases for HIST1H2BK Gene

Aliases for HIST1H2BK Gene

  • Histone Cluster 1, H2bk 2 3
  • H2B Histone Family, Member T 2 3
  • HIRA-Interacting Protein 1 3 4
  • Histone 1, H2bk 2 3
  • H2B K 3 4
  • H2BFT 3 4
  • Histone Family Member 3
  • H2BFAiii 3
  • HIRIP1 4
  • H2B/S 3
  • H2BK 3

External Ids for HIST1H2BK Gene

Previous HGNC Symbols for HIST1H2BK Gene

  • H2BFT

Previous GeneCards Identifiers for HIST1H2BK Gene

  • GC06M027163
  • GC06M027214
  • GC06M027105
  • GC06M026914

Summaries for HIST1H2BK Gene

Entrez Gene Summary for HIST1H2BK Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BK Gene

HIST1H2BK (Histone Cluster 1, H2bk) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot for HIST1H2BK Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST1H2BK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BK Gene

Genomics for HIST1H2BK Gene

Regulatory Elements for HIST1H2BK Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST1H2BK Gene

Chromosome:
6
Start:
27,138,293 bp from pter
End:
27,146,858 bp from pter
Size:
8,566 bases
Orientation:
Minus strand

Genomic View for HIST1H2BK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for HIST1H2BK Gene

Proteins for HIST1H2BK Gene

  • Protein details for HIST1H2BK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60814-H2B1K_HUMAN
    Recommended name:
    Histone H2B type 1-K
    Protein Accession:
    O60814
    Secondary Accessions:
    • A8K7P7
    • Q2VPI7

    Protein attributes for HIST1H2BK Gene

    Size:
    126 amino acids
    Molecular mass:
    13890 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

    Three dimensional structures from OCA and Proteopedia for HIST1H2BK Gene

neXtProt entry for HIST1H2BK Gene

Proteomics data for HIST1H2BK Gene at MOPED

Post-translational modifications for HIST1H2BK Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BK Gene

Domains & Families for HIST1H2BK Gene

Gene Families for HIST1H2BK Gene

HGNC:

Protein Domains for HIST1H2BK Gene

Suggested Antigen Peptide Sequences for HIST1H2BK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60814

UniProtKB/Swiss-Prot:

H2B1K_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BK: view

Function for HIST1H2BK Gene

Molecular function for HIST1H2BK Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Ontology (GO) - Molecular Function for HIST1H2BK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BK: view
genes like me logo Genes that share phenotypes with HIST1H2BK: view

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2BK
    • Block miRNA regulation of HIST1H2BK using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BK

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BK Gene

    Localization for HIST1H2BK Gene

    Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BK Gene

    Nucleus. Chromosome.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for HIST1H2BK Gene COMPARTMENTS Subcellular localization image for HIST1H2BK gene
    Compartment Confidence
    extracellular 5
    nucleus 5

    Gene Ontology (GO) - Cellular Components for HIST1H2BK Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0000786 nucleosome --
    GO:0000788 nuclear nucleosome IBA --
    GO:0005615 extracellular space IDA 12860195
    GO:0005634 nucleus IDA 16319397
    GO:0005654 nucleoplasm TAS --
    genes like me logo Genes that share ontologies with HIST1H2BK: view

    Pathways & Interactions for HIST1H2BK Gene

    SuperPathways for HIST1H2BK Gene

    Superpath Contained pathways
    1 RNA Polymerase I Promoter Opening
    2 RNA Polymerase I Transcription
    3 G2/M DNA damage checkpoint
    4 DNA Double-Strand Break Repair
    5 Cellular Senescence
    genes like me logo Genes that share pathways with HIST1H2BK: view

    Pathways by source for HIST1H2BK Gene

    Gene Ontology (GO) - Biological Process for HIST1H2BK Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0002227 innate immune response in mucosa IDA 12860195
    GO:0006325 chromatin organization TAS --
    GO:0006334 nucleosome assembly IBA --
    GO:0019731 antibacterial humoral response IDA 12860195
    GO:0050830 defense response to Gram-positive bacterium IDA 12860195
    genes like me logo Genes that share ontologies with HIST1H2BK: view

    No data available for SIGNOR curated interactions for HIST1H2BK Gene

    Drugs & Compounds for HIST1H2BK Gene

    No Compound Related Data Available

    Transcripts for HIST1H2BK Gene

    mRNA/cDNA for HIST1H2BK Gene

    Unigene Clusters for HIST1H2BK Gene

    Histone cluster 1, H2bk:
    Representative Sequences:

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2BK
      • Block miRNA regulation of HIST1H2BK using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BK

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BK Gene

      No ASD Table

      Relevant External Links for HIST1H2BK Gene

      GeneLoc Exon Structure for
      HIST1H2BK
      ECgene alternative splicing isoforms for
      HIST1H2BK

      Expression for HIST1H2BK Gene

      mRNA expression in normal human tissues for HIST1H2BK Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for HIST1H2BK Gene

      This gene is overexpressed in Whole Blood (x10.6).

      Protein differential expression in normal tissues from HIPED for HIST1H2BK Gene

      This gene is overexpressed in Saliva (52.0).

      Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H2BK Gene



      SOURCE GeneReport for Unigene cluster for HIST1H2BK Gene Hs.437275

      genes like me logo Genes that share expression patterns with HIST1H2BK: view

      Protein tissue co-expression partners for HIST1H2BK Gene

      - Elite partner

      Primer Products

      In Situ Assay Products

      No data available for mRNA Expression by UniProt/SwissProt for HIST1H2BK Gene

      Orthologs for HIST1H2BK Gene

      This gene was present in the common ancestor of mammals.

      Orthologs for HIST1H2BK Gene

      Organism Taxonomy Gene Similarity Type Details
      cow
      (Bos Taurus)
      Mammalia HIST1H2BM 35
      • 90.74 (n)
      • 98.41 (a)
      HIST1H2BK 36
      • 100 (a)
      OneToOne
      dog
      (Canis familiaris)
      Mammalia LOC488303 35
      • 92.86 (n)
      • 100 (a)
      HIST1H2BK 36
      • 100 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Hist1h2bk 35
      • 92.06 (n)
      • 99.21 (a)
      Hist1h2bk 16
      Hist1h2bk 36
      • 99 (a)
      OneToOne
      chimpanzee
      (Pan troglodytes)
      Mammalia HIST1H2BK 35
      • 99.47 (n)
      • 100 (a)
      HIST1H2BK 36
      • 100 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia Hist1h2bk 35
      • 90.74 (n)
      • 100 (a)
      platypus
      (Ornithorhynchus anatinus)
      Mammalia -- 36
      • 91 (a)
      OneToMany
      Species with no ortholog for HIST1H2BK:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for HIST1H2BK Gene

      ENSEMBL:
      Gene Tree for HIST1H2BK (if available)
      TreeFam:
      Gene Tree for HIST1H2BK (if available)

      Paralogs for HIST1H2BK Gene

      genes like me logo Genes that share paralogs with HIST1H2BK: view

      Variants for HIST1H2BK Gene

      Sequence variations from dbSNP and Humsavar for HIST1H2BK Gene

      SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
      rs2021278 -- 27,143,211(-) ccatg(C/G)ctggc intron-variant
      rs2393916 -- 27,141,044(+) TCAAT(C/T)TGGGG intron-variant
      rs3999103 -- 27,140,769(+) TTCCC(A/G)CTTTC intron-variant
      rs3999105 -- 27,141,032(+) GAGCT(A/G)CAGGC intron-variant
      rs6927247 -- 27,143,330(+) cttgg(C/T)gacag intron-variant

      Variation tolerance for HIST1H2BK Gene

      Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
      Gene Damage Index Score: 0.47; 10.28% of all genes are more intolerant (likely to be disease-causing)

      Relevant External Links for HIST1H2BK Gene

      HapMap Linkage Disequilibrium report
      HIST1H2BK

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BK Gene

      Disorders for HIST1H2BK Gene

      Relevant External Links for HIST1H2BK

      Atlas of Genetics and Cytogenetics in Oncology and Haematology:
      HIST1H2BK
      genes like me logo Genes that share disorders with HIST1H2BK: view

      No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BK Gene

      Publications for HIST1H2BK Gene

      1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 67
      2. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PMID: 23463506) Perez-Hernandez D. … YA!A+ez-MA^ M. (J. Biol. Chem. 2013) 67
      3. Regulation of error-prone translesion synthesis by Spartan/C1orf124. (PMID: 23254330) Kim M.S. … Machida Y.J. (Nucleic Acids Res. 2013) 67
      4. USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing. (PMID: 23824326) Zhang Z. … Wang H. (Genes Dev. 2013) 67
      5. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PMID: 21907836) Zhao J. … Yang P. (J Proteomics 2011) 67

      Products for HIST1H2BK Gene

      Sources for HIST1H2BK Gene

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