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Aliases for HIST1H2BK Gene

Aliases for HIST1H2BK Gene

  • Histone Cluster 1 H2B Family Member K 2 3 5
  • H2B Histone Family, Member T 2 3
  • HIRA-Interacting Protein 1 3 4
  • Histone Cluster 1, H2bk 2 3
  • Histone 1, H2bk 2 3
  • H2B K 3 4
  • H2BFT 3 4
  • Histone Family Member 3
  • Histone H2B Type 1-K 3
  • H2BFAiii 3
  • HIRIP1 4
  • H2B/S 3
  • H2BK 3

External Ids for HIST1H2BK Gene

Previous HGNC Symbols for HIST1H2BK Gene

  • H2BFT

Previous GeneCards Identifiers for HIST1H2BK Gene

  • GC06M027163
  • GC06M027214
  • GC06M027105
  • GC06M026914

Summaries for HIST1H2BK Gene

Entrez Gene Summary for HIST1H2BK Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BK Gene

HIST1H2BK (Histone Cluster 1 H2B Family Member K) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BF.

UniProtKB/Swiss-Prot for HIST1H2BK Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Wiki entry for HIST1H2BK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BK Gene

Genomics for HIST1H2BK Gene

Regulatory Elements for HIST1H2BK Gene

Enhancers for HIST1H2BK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G027176 1.8 FANTOM5 Ensembl ENCODE 13 -30.8 -30755 3.2 AGO1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 ZNF610 RCOR2 ABT1 BTN3A2 ZKSCAN8 ZNF204P ZNF391 HIST1H2BK ENSG00000261353 ZNF192P1 POM121L2 ZNF603P
GH06G027114 0.9 ENCODE 10.7 +31.8 31779 0.9 TBP PKNOX1 ATF1 ARNT RAD21 CHAMP1 YY1 TCF12 ZNF766 FOS HIST1H2BK ABT1 ENSG00000272468 RNU2-62P GC06M027113
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST1H2BK on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H2BK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195093 258 3201 CREB3L1 AGO1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 SSRP1

Genomic Location for HIST1H2BK Gene

Chromosome:
6
Start:
27,138,293 bp from pter
End:
27,146,858 bp from pter
Size:
8,566 bases
Orientation:
Minus strand

Genomic View for HIST1H2BK Gene

Genes around HIST1H2BK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2BK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2BK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BK Gene

Proteins for HIST1H2BK Gene

  • Protein details for HIST1H2BK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60814-H2B1K_HUMAN
    Recommended name:
    Histone H2B type 1-K
    Protein Accession:
    O60814
    Secondary Accessions:
    • A8K7P7
    • Q2VPI7

    Protein attributes for HIST1H2BK Gene

    Size:
    126 amino acids
    Molecular mass:
    13890 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2BK Gene

neXtProt entry for HIST1H2BK Gene

Post-translational modifications for HIST1H2BK Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at isoforms=121
  • Glycosylation at posLast=113113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BK Gene

Domains & Families for HIST1H2BK Gene

Gene Families for HIST1H2BK Gene

Protein Domains for HIST1H2BK Gene

Suggested Antigen Peptide Sequences for HIST1H2BK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60814

UniProtKB/Swiss-Prot:

H2B1K_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BK: view

Function for HIST1H2BK Gene

Molecular function for HIST1H2BK Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Ontology (GO) - Molecular Function for HIST1H2BK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BK: view
genes like me logo Genes that share phenotypes with HIST1H2BK: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BK Gene

Localization for HIST1H2BK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BK Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H2BK gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for HIST1H2BK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005615 extracellular space IDA 12860195
GO:0005634 nucleus IDA 16319397
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with HIST1H2BK: view

Pathways & Interactions for HIST1H2BK Gene

SuperPathways for HIST1H2BK Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H2BK: view

Gene Ontology (GO) - Biological Process for HIST1H2BK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006334 nucleosome assembly IBA --
GO:0016567 protein ubiquitination TAS --
GO:0019731 antibacterial humoral response IDA 12860195
GO:0031640 killing of cells of other organism IDA 15019208
genes like me logo Genes that share ontologies with HIST1H2BK: view

No data available for SIGNOR curated interactions for HIST1H2BK Gene

Drugs & Compounds for HIST1H2BK Gene

No Compound Related Data Available

Transcripts for HIST1H2BK Gene

mRNA/cDNA for HIST1H2BK Gene

Unigene Clusters for HIST1H2BK Gene

Histone cluster 1, H2bk:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BK Gene

No ASD Table

Relevant External Links for HIST1H2BK Gene

GeneLoc Exon Structure for
HIST1H2BK
ECgene alternative splicing isoforms for
HIST1H2BK

Expression for HIST1H2BK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H2BK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2BK Gene

This gene is overexpressed in Whole Blood (x10.6).

Protein differential expression in normal tissues from HIPED for HIST1H2BK Gene

This gene is overexpressed in Saliva (52.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H2BK Gene



Protein tissue co-expression partners for HIST1H2BK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HIST1H2BK Gene:

HIST1H2BK

SOURCE GeneReport for Unigene cluster for HIST1H2BK Gene:

Hs.437275

Evidence on tissue expression from TISSUES for HIST1H2BK Gene

  • Stomach(4.3)
  • Pancreas(4.2)
  • Intestine(2)
genes like me logo Genes that share expression patterns with HIST1H2BK: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2BK Gene

Orthologs for HIST1H2BK Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2BK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIST1H2BK 35
  • 100 (a)
OneToOne
HIST1H2BM 34
  • 90.74 (n)
dog
(Canis familiaris)
Mammalia HIST1H2BK 35
  • 100 (a)
OneToOne
LOC488303 34
  • 92.86 (n)
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BK 34 35
  • 99.47 (n)
mouse
(Mus musculus)
Mammalia Hist1h2bk 34 16 35
  • 92.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 91 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hist1h2bk 34
  • 90.74 (n)
Species where no ortholog for HIST1H2BK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2BK Gene

ENSEMBL:
Gene Tree for HIST1H2BK (if available)
TreeFam:
Gene Tree for HIST1H2BK (if available)

Paralogs for HIST1H2BK Gene

Variants for HIST1H2BK Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000523775 -- 27,147,863(+) ACAGG(C/T)TGGAG downstream-variant-500B, upstream-variant-2KB
rs1000535928 -- 27,144,468(+) GGGGG(A/C/G/T)GGGGG intron-variant
rs1000619674 -- 27,138,650(+) CTTGG(G/T)CATAT upstream-variant-2KB, utr-variant-3-prime
rs1000637352 -- 27,144,605(+) ACTTC(C/T)AGAAT intron-variant
rs1001361991 -- 27,148,034(+) GGCCA(C/G)GCTGG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BK Gene

Variant ID Type Subtype PubMed ID
nsv1029124 CNV loss 25217958
nsv970091 CNV duplication 23825009

Variation tolerance for HIST1H2BK Gene

Residual Variation Intolerance Score: 51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2BK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H2BK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BK Gene

Disorders for HIST1H2BK Gene

Relevant External Links for HIST1H2BK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2BK

No disorders were found for HIST1H2BK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BK Gene

Publications for HIST1H2BK Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  2. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R. … Reinberg D. (Cell 2006) 3 4 64
  3. Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck H.C. … Jensen O.N. (Mol. Cell. Proteomics 2006) 3 4 64
  4. Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N. … Pesavento J.J. (J. Proteome Res. 2006) 3 4 64
  5. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4 64

Products for HIST1H2BK Gene

Sources for HIST1H2BK Gene

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