Aliases for HIST1H2BK Gene
Aliases for HIST1H2BK Gene
External Ids for HIST1H2BK Gene
- HGNC: 13954
- Entrez Gene: 85236
- Ensembl: ENSG00000197903
- OMIM: 615045
- UniProtKB: O60814
Previous HGNC Symbols for HIST1H2BK Gene
- H2BFT
Previous GeneCards Identifiers for HIST1H2BK Gene
- GC06M027163
- GC06M027214
- GC06M027105
- GC06M026914
Summaries for HIST1H2BK Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family. The protein encoded is an antimicrobial protein with antibacterial and antifungal activity. Two transcripts that encode the same protein have been identified for this gene, which is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H2BK Gene
HIST1H2BK (Histone Cluster 1 H2B Family Member K) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BF.
UniProtKB/Swiss-Prot for HIST1H2BK Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
-
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BK Gene
Genomics for HIST1H2BK Gene
Regulatory Elements for HIST1H2BK Gene
Enhancers for HIST1H2BK Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G027176 | 1.8 | FANTOM5 Ensembl ENCODE | 13.1 | -30.8 | -30755 | 3.2 | AGO1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 ZNF610 RCOR2 | ABT1 BTN3A2 ZKSCAN8 ZNF204P ZNF391 HIST1H2BK ENSG00000261353 ZNF192P1 POM121L2 ZNF603P |
| GH06G027114 | 0.9 | ENCODE | 10.7 | +31.8 | 31779 | 0.9 | TBP PKNOX1 ATF1 ARNT RAD21 CHAMP1 YY1 TCF12 ZNF766 FOS | HIST1H2BK ABT1 GC06M027113 ENSG00000272468 RNU2-62P |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H2BK on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST1H2BK gene promoter:
Regulatory Element Products
Genomic Location for HIST1H2BK Gene
- Chromosome:
- 6
- Start:
- 27,138,293 bp from pter
- End:
- 27,146,858 bp from pter
- Size:
- 8,566 bases
- Orientation:
- Minus strand
Genomic View for HIST1H2BK Gene
Genes around HIST1H2BK on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by Ensembl
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC
HIST1H2BK Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H2BK Gene
Proteins for HIST1H2BK Gene
-
Protein details for HIST1H2BK Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60814-H2B1K_HUMAN
- Recommended name:
- Histone H2B type 1-K
- Protein Accession:
- O60814
- A8K7P7
- Q2VPI7
Protein attributes for HIST1H2BK Gene
- Size:
- 126 amino acids
- Molecular mass:
- 13890 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST1H2BK Gene
Post-translational modifications for HIST1H2BK Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
- Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- Ubiquitination at isoforms=121
- Glycosylation at posLast=113113
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H2BK Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for HIST1H2BK
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for HIST1H2BK Gene
Domains & Families for HIST1H2BK Gene
Gene Families for HIST1H2BK Gene
- HGNC:
Protein Domains for HIST1H2BK Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H2BK Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O60814- Family:
-
- Belongs to the histone H2B family.
Function for HIST1H2BK Gene
Molecular function for HIST1H2BK Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- UniProtKB/Swiss-Prot Function:
- Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003677 | DNA binding | IBA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H2BK Gene
- GenomeRNAi human phenotypes for HIST1H2BK:
-
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Increased G1 DNA content
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2BK gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BK gene
- Search ViGene Biosciences for HIST1H2BK
CRISPR Products
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-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BK
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miRNA for HIST1H2BK Gene
- miRTarBase miRNAs that target HIST1H2BK
-
- hsa-mir-98-5p (MIRT027811)
- hsa-mir-1292-5p (MIRT035830)
- hsa-mir-1180-3p (MIRT035923)
- hsa-mir-423-5p (MIRT038110)
- hsa-mir-424-5p (MIRT042437)
- hsa-mir-324-3p (MIRT042857)
- hsa-mir-320a (MIRT044421)
- hsa-mir-186-5p (MIRT045125)
- hsa-mir-138-5p (MIRT045835)
- hsa-mir-31-5p (MIRT049866)
- hsa-mir-16-5p (MIRT051151)
- hsa-mir-15a-5p (MIRT051316)
- hsa-mir-3158-5p (MIRT218484)
- hsa-mir-6738-3p (MIRT454151)
- hsa-mir-544a (MIRT454152)
- hsa-mir-218-5p (MIRT454153)
- hsa-mir-636 (MIRT454154)
- hsa-mir-6740-3p (MIRT454155)
- hsa-mir-3935 (MIRT454156)
- hsa-mir-103a-2-5p (MIRT454157)
- hsa-mir-202-3p (MIRT454158)
- hsa-mir-4500 (MIRT454159)
- hsa-mir-4458 (MIRT454160)
- hsa-let-7i-5p (MIRT454161)
- hsa-let-7g-5p (MIRT454162)
- hsa-let-7f-5p (MIRT454163)
- hsa-let-7e-5p (MIRT454164)
- hsa-let-7d-5p (MIRT454165)
- hsa-let-7c-5p (MIRT454166)
- hsa-let-7b-5p (MIRT454167)
- hsa-let-7a-5p (MIRT454168)
- hsa-mir-605-3p (MIRT454169)
- hsa-mir-627-3p (MIRT454170)
- hsa-mir-4778-3p (MIRT454171)
- hsa-mir-17-3p (MIRT454172)
- hsa-mir-1205 (MIRT454173)
- hsa-mir-1184 (MIRT454174)
- hsa-mir-936 (MIRT454175)
- hsa-mir-577 (MIRT454176)
miRNA Products
- Search ViGene Biosciences for HIST1H2BK
Inhibitory RNA Products
- Origene shRNA and siRNA products in human, mouse, rat for HIST1H2BK
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-
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HIST1H2BK
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BK Gene
Localization for HIST1H2BK Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BK Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005615 | extracellular space | IDA | 12860195 |
| GO:0005634 | nucleus | IDA | 16319397 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HIST1H2BK Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST1H2BK Gene
68 Reactome pathways for HIST1H2BK Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H2BK Gene
Interacting Proteins for HIST1H2BK Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
| GO:0006334 | nucleosome assembly | IBA | -- |
| GO:0016567 | protein ubiquitination | TAS | -- |
| GO:0019731 | antibacterial humoral response | IDA | 12860195 |
| GO:0031640 | killing of cells of other organism | IDA | 15019208 |
No data available for SIGNOR curated interactions for HIST1H2BK Gene
Transcripts for HIST1H2BK Gene
mRNA/cDNA for HIST1H2BK Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (253) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H2BK Gene
CRISPR Products
- Browse CRISPR knockouts for HIST1H2BK
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BK
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miRNA Products
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Inhibitory RNA Products
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Clone Products
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- Addgene plasmids for HIST1H2BK
Flow Cytometry Products
Expression for HIST1H2BK Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HIST1H2BK Gene
This gene is overexpressed in Whole Blood (x10.6).
This gene is overexpressed in Saliva (52.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H2BK Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HIST1H2BK Gene:
HIST1H2BKSOURCE GeneReport for Unigene cluster for HIST1H2BK Gene:
Hs.437275Evidence on tissue expression from TISSUES for HIST1H2BK Gene
- Stomach(4.3)
- Pancreas(4.2)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HIST1H2BK
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2BK Gene
Orthologs for HIST1H2BK Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HIST1H2BK 35 |
|
OneToOne | |
| HIST1H2BM 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | HIST1H2BK 35 |
|
OneToOne | |
| LOC488303 34 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | HIST1H2BK 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist1h2bk 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| rat (Rattus norvegicus) |
Mammalia | Hist1h2bk 34 |
|
- Species where no ortholog for HIST1H2BK was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIST1H2BK Gene
Paralogs for HIST1H2BK Gene
(23) SIMAP similar genes for HIST1H2BK Gene using alignment to 1 proteins:
Variants for HIST1H2BK Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000523775 | -- | 27,147,863(+) | ACAGG(C/T)TGGAG | downstream-variant-500B, upstream-variant-2KB | |
| rs1000535928 | -- | 27,144,468(+) | GGGGG(A/C/G/T)GGGGG | intron-variant | |
| rs1000619674 | -- | 27,138,650(+) | CTTGG(G/T)CATAT | upstream-variant-2KB, utr-variant-3-prime | |
| rs1000637352 | -- | 27,144,605(+) | ACTTC(C/T)AGAAT | intron-variant | |
| rs1001361991 | -- | 27,148,034(+) | GGCCA(C/G)GCTGG | downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1029124 | CNV | loss | 25217958 |
| nsv970091 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.47;
10.28% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H2BK Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H2BK
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BK Gene
Disorders for HIST1H2BK Gene
Relevant External Links for HIST1H2BK
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H2BK
No disorders were found for HIST1H2BK Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BK Gene
Publications for HIST1H2BK Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R. … Reinberg D. (Cell 2006) 3 4 64
- Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck H.C. … Jensen O.N. (Mol. Cell. Proteomics 2006) 3 4 64
- Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N. … Pesavento J.J. (J. Proteome Res. 2006) 3 4 64
- Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4 64
Products for HIST1H2BK Gene
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Sources for HIST1H2BK Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer