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Aliases for HIST1H2BJ Gene

Aliases for HIST1H2BJ Gene

  • Histone Cluster 1, H2bj 2 3
  • H2B Histone Family, Member R 2 3
  • Histone 1, H2bj 2 3
  • Histone H2B.1 3 4
  • Histone H2B.R 3 4
  • H2BFR 3 4
  • H2B/R 3 4
  • H2BJ 3 6
  • Histone H2B Type 1-J 3

External Ids for HIST1H2BJ Gene

Previous HGNC Symbols for HIST1H2BJ Gene

  • H2BFR

Previous GeneCards Identifiers for HIST1H2BJ Gene

  • GC06M027158
  • GC06M027208
  • GC06M027100
  • GC06M026910
  • GC06M027096

Summaries for HIST1H2BJ Gene

Entrez Gene Summary for HIST1H2BJ Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2BJ Gene

HIST1H2BJ (Histone Cluster 1, H2bj) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot for HIST1H2BJ Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST1H2BJ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BJ Gene

Genomics for HIST1H2BJ Gene

Regulatory Elements for HIST1H2BJ Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST1H2BJ Gene

Start:
27,125,897 bp from pter
End:
27,132,796 bp from pter
Size:
6,900 bases
Orientation:
Minus strand

Genomic View for HIST1H2BJ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2BJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BJ Gene

Proteins for HIST1H2BJ Gene

  • Protein details for HIST1H2BJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06899-H2B1J_HUMAN
    Recommended name:
    Histone H2B type 1-J
    Protein Accession:
    P06899
    Secondary Accessions:
    • B2R4J4
    • O60816

    Protein attributes for HIST1H2BJ Gene

    Size:
    126 amino acids
    Molecular mass:
    13904 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2BJ Gene

neXtProt entry for HIST1H2BJ Gene

Proteomics data for HIST1H2BJ Gene at MOPED

Post-translational modifications for HIST1H2BJ Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys6, Lys44, Lys47, Lys58, Lys109, Lys117, and Lys121
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BJ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BJ Gene

Domains for HIST1H2BJ Gene

Gene Families for HIST1H2BJ Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2BJ Gene

Suggested Antigen Peptide Sequences for HIST1H2BJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06899

UniProtKB/Swiss-Prot:

H2B1J_HUMAN :
  • P06899
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BJ: view

Function for HIST1H2BJ Gene

Molecular function for HIST1H2BJ Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
UniProtKB/Swiss-Prot Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Ontology (GO) - Molecular Function for HIST1H2BJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 6647026
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BJ: view

Phenotypes for HIST1H2BJ Gene

GenomeRNAi human phenotypes for HIST1H2BJ:
genes like me logo Genes that share phenotypes with HIST1H2BJ: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BJ

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2BJ Gene

Localization for HIST1H2BJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BJ Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BJ Gene COMPARTMENTS Subcellular localization image for HIST1H2BJ gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2BJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome NAS 6647026
GO:0000788 nuclear nucleosome IBA --
GO:0005615 extracellular space IDA 12860195
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
genes like me logo Genes that share ontologies with HIST1H2BJ: view

Pathways for HIST1H2BJ Gene

genes like me logo Genes that share pathways with HIST1H2BJ: view

Pathways by source for HIST1H2BJ Gene

29 Reactome pathways for HIST1H2BJ Gene
3 KEGG pathways for HIST1H2BJ Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2BJ Gene

Gene Ontology (GO) - Biological Process for HIST1H2BJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002227 innate immune response in mucosa IDA 12860195
GO:0006325 chromatin organization TAS --
GO:0006334 nucleosome assembly NAS 6647026
GO:0019731 antibacterial humoral response IDA 12860195
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with HIST1H2BJ: view

Transcripts for HIST1H2BJ Gene

mRNA/cDNA for HIST1H2BJ Gene

(253) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2BJ Gene

Histone cluster 1, H2bj:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BJ

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST1H2BJ

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BJ Gene

No ASD Table

Relevant External Links for HIST1H2BJ Gene

GeneLoc Exon Structure for
HIST1H2BJ
ECgene alternative splicing isoforms for
HIST1H2BJ

Expression for HIST1H2BJ Gene

mRNA expression in normal human tissues for HIST1H2BJ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2BJ Gene

This gene is overexpressed in Whole Blood (11.1) and Testis (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HIST1H2BJ Gene

SOURCE GeneReport for Unigene cluster for HIST1H2BJ Gene Hs.656567

genes like me logo Genes that share expressions with HIST1H2BJ: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H2BJ Gene

Orthologs for HIST1H2BJ Gene

This gene was present in the common ancestor of animals.

Orthologs for HIST1H2BJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BJ 36
  • 100 (a)
OneToOne
HIST1H2BK 35
  • 98.94 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HIST1H2BJ 36
  • 99 (a)
OneToOne
LOC522960 35
  • 91.01 (n)
  • 99.21 (a)
dog
(Canis familiaris)
Mammalia HIST1H2BJ 36
  • 100 (a)
OneToOne
LOC488288 35
  • 92.59 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hist1h2bj 16
Hist2h2be 35
  • 86.51 (n)
  • 97.62 (a)
Hist2h2be 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hist2h2be 35
  • 85.45 (n)
  • 97.62 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 82 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487485 35
  • 85.98 (n)
  • 94.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ano9a 36
  • 87 (a)
ManyToMany
ano9a 36
  • 94 (a)
ManyToMany
CABZ01086354.1 36
  • 86 (a)
ManyToMany
si:dkey-261m9.19 36
  • 86 (a)
ManyToMany
si:dkey-261m9.6 36
  • 86 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 87 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 94 (a)
ManyToMany
wu:fe11b02 36
  • 94 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 86 (a)
ManyToMany
zgc:112234 36
  • 86 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 86 (a)
ManyToMany
zgc:171759 36
  • 93 (a)
ManyToMany
zgc:171759 36
  • 47 (a)
ManyToMany
zgc:171759 36
  • 86 (a)
ManyToMany
zgc:171759 36
  • 85 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 89 (a)
ManyToMany
zgc:171759 36
  • 89 (a)
ManyToMany
zgc:173587 36
  • 86 (a)
ManyToMany
zgc:194989 36
  • 93 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta H2B_ANOGA_e 35
  • 76.23 (n)
  • 81.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta His2B:CG33872 35
  • 76.11 (n)
  • 86.67 (a)
worm
(Caenorhabditis elegans)
Secernentea his-54 35
  • 69.59 (n)
  • 83.33 (a)
Species with no ortholog for HIST1H2BJ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST1H2BJ Gene

ENSEMBL:
Gene Tree for HIST1H2BJ (if available)
TreeFam:
Gene Tree for HIST1H2BJ (if available)

Paralogs for HIST1H2BJ Gene

Pseudogenes.org Pseudogenes for HIST1H2BJ Gene

genes like me logo Genes that share paralogs with HIST1H2BJ: view

Variants for HIST1H2BJ Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BJ Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs41269251 -- 27,134,049(+) AGGCT(C/G)TGTCA upstream-variant-2KB
rs73739598 -- 27,134,112(+) TACTG(C/G)ATGTT upstream-variant-2KB
rs113772082 -- 27,134,431(+) AAAAG(-/T)TACAG upstream-variant-2KB
rs116592283 -- 27,134,089(+) GTGAA(A/G)CATTC upstream-variant-2KB
rs149432701 -- 27,134,329(+) AGATA(G/T)GAGGG upstream-variant-2KB

Relevant External Links for HIST1H2BJ Gene

HapMap Linkage Disequilibrium report
HIST1H2BJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BJ Gene

Disorders for HIST1H2BJ Gene

Relevant External Links for HIST1H2BJ

Genetic Association Database (GAD)
HIST1H2BJ
Human Genome Epidemiology (HuGE) Navigator
HIST1H2BJ
genes like me logo Genes that share disorders with HIST1H2BJ: view

No data available for UniProtKB/Swiss-Prot for HIST1H2BJ Gene

Publications for HIST1H2BJ Gene

  1. The primary structure and expression of four cloned human histone genes. (PMID: 6647026) Zhong R. … Heintz N. (Nucleic Acids Res. 1983) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. Antimicrobial polypeptides of the human colonic epithelium. (PMID: 15019208) Howell S.J. … Bevins C.L. (Peptides 2003) 3 4
  4. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4
  5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PMID: 16307923) Zhu B. … Reinberg D. (Mol. Cell 2005) 3 4

Products for HIST1H2BJ Gene

Sources for HIST1H2BJ Gene

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