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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2BJ Gene

protein-coding   GIFtS: 54
GCID: GC06M027096

Histone Cluster 1, H2bj

(Previous names: H2B histone family, member R, histone 1, H2bj)
(Previous symbol: H2BFR)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H2bj1 2     Histone H2B.R2 3
H2BFR1 2 3     H2B/r2 3
H2B Histone Family, Member R1 2     H2BJ2
Histone 1, H2bj1 2     Histone H2B Type 1-J2
Histone H2B.12 3     

External Ids:    HGNC: 47611   Entrez Gene: 89702   Ensembl: ENSG000001246357   OMIM: 6150445   UniProtKB: P068993   

Export aliases for HIST1H2BJ gene to outside databases

Previous GC identifers: GC06M027158 GC06M027208 GC06M027100 GC06M026910


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2BJ Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on
chromosome 6p21.33. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2BJ Gene: 
HIST1H2BJ (histone cluster 1, H2bj) is a protein-coding gene. Diseases associated with HIST1H2BJ include systemic lupus erythematosus, and lupus erythematosus, and among its related super-pathways are Signal transduction Activin A signaling regulation and Telomere Maintenance. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot: H2B1J_HUMAN, P06899
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling
Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST1H2BJ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2BJ gene promoter:
         AML1a   Pax-5   HTF   GCNF   MIF-1   GCNF-1   FOXO4   GCNF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2BJ promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2BJ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BJ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2BJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BJ gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027096:  view genomic region     (about GC identifiers)

Start:
27,093,676 bp from pter      End:
27,100,575 bp from pter
Size:
6,900 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H2B1J_HUMAN, P06899 (See protein sequence)
Recommended Name: Histone H2B type 1-J  
Size: 126 amino acids; 13904 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
6/16 PDB 3D structures from and Proteopedia for HIST1H2BJ (see all 16):
3A6N (3D)        3AFA (3D)        3AN2 (3D)        3AV1 (3D)        3AV2 (3D)        3AYW (3D)    
Secondary accessions: B2R4J4 O60816

Explore the universe of human proteins at neXtProt for HIST1H2BJ: NX_P06899

Explore proteomics data for HIST1H2BJ at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II
  • UniProtKB: Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination
  • UniProtKB: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes (By similarity)
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06899

  • HIST1H2BJ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H2BJ Protein Expression
    REFSEQ proteins: NP_066402.2  
    ENSEMBL proteins: 
     ENSP00000476136   ENSP00000475213   ENSP00000342886   ENSP00000445633  
    Reactome Protein details: P06899
    Human Recombinant Protein Products for HIST1H2BJ: 
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    Cloud-Clone Corp. Proteins for HIST1H2BJ 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS6647026
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    HIST1H2BJ for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P06899

    ProtoNet protein and cluster: P06899

    UniProtKB/Swiss-Prot: H2B1J_HUMAN, P06899
    Similarity: Belongs to the histone H2B family


    HIST1H2BJ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B1J_HUMAN, P06899
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling
    Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
    barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS6647026
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    HIST1H2BJ for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HIST1H2BJ:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H2BJ 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H2BJ 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H2BJ About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.56
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    Telomere Maintenance0.56
    Amyloids0.41
    Nucleosome assembly0.46
    3Meiotic Synapsis
    Meiotic Synapsis0.70
    Meiotic Recombination0.62
    Meiosis0.70
    Chromosome Maintenance0.56
    4Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    5Cell Cycle
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2BJ
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2BJ
        Signal transduction Activin A signaling regulation

    5/11        Reactome Pathways for HIST1H2BJ (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST1H2BJ):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H2BJ for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2BJ

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for HIST1H2BJ (P068993 ENSP000003428864) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LOXP283003I2D: score=2 
    TLX3O437113I2D: score=1 
    UBR2ENSP000003619904STRING: ENSP00000361990
    HDGFENSP000003571894STRING: ENSP00000357189
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS6647026
    GO:0042742defense response to bacterium IEA--

    HIST1H2BJ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2BJ (H2B1J)

    Search CenterWatch for drugs/clinical trials and news about HIST1H2BJ / H2B1J

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H2BJ gene: 
    NM_021058.3  

    Unigene Cluster for HIST1H2BJ:

    Histone cluster 1, H2bj
    Hs.656567  [show with all ESTs]
    Unigene Representative Sequence: BX956575
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000607124 ENST00000606923 ENST00000339812(uc003niv.3) ENST00000541790(uc003niu.1)

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    1 DOTS entry:

    DT.100652610 

    24/253 AceView cDNA sequences (see all 253):

    BU178943 NM_021058 AI356671 BC064959 BX094548 BQ001976 BU618944 CB129361 
    BM997865 CB123835 BM013915 CB106839 BU623637 AI138510 AW274702 CF130147 
    AW879006 BM839785 BM991442 CD367886 BU632005 BQ945730 BC000893 CA441092 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2BJ expression in normal human tissues (normalized intensities)      HIST1H2BJ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCGTTTG
    HIST1H2BJ Expression
    About this image


    HIST1H2BJ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer

    See HIST1H2BJ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2BJ

    SOURCE GeneReport for Unigene cluster: Hs.656567
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HIST1H2BJ gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2bj5
    Hist1h2bk1
    histone cluster 1, H2bj5
    histone cluster 1, H2bk1
    89.95(n)1
    98.41(a)1
      13 (8.15 cM)5
    3191841  NM_175665.11  NP_783596.11 
     220432145 
    chicken
    (Gallus gallus)
    Aves H2B-I6
    H2B-I6
    (see all 5)
    Histone H2B 1/2/3/4/6
    (see all 5)
    96(a)
    96(a)
    (see all 5)
    possible ortholog
    possible ortholog
    (see all 5)
    1(48010779-48011912)
    1(48031982-48032362)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Histone H2B
    (see all 4)
    94(a)
    94(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    GL343466.1(314932-315312)
    GL343252.1(1828391-1828771)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1122346
    --
    (see all 33)
    --
    94(a)
    94(a)
    (see all 33)
    many ↔ many
    many ↔ many
    (see all 33)
    7(7267124-7267498)
    7(76859940-76860314)
    fruit fly
    (Drosophila melanogaster)
    Insecta His2B:CG338886
    His2B:CG338846
    (see all 14)
    His2B:CG33884
    (see all 14)
    82(a)
    82(a)
    (see all 14)
    possible ortholog
    possible ortholog
    (see all 14)
    2L(21487832-21488386)
    2L(21497922-21498476)
    worm
    (Caenorhabditis elegans)
    Secernentea his-116
    his-156
    (see all 6)
    Histone H2B 1
    (see all 6)
    81(a)
    81(a)
    (see all 6)
    many ↔ many
    many ↔ many
    (see all 6)
    II(13821778-13822314)
    II(13818371-13818739)


    ENSEMBL Gene Tree for HIST1H2BJ (if available)
    TreeFam Gene Tree for HIST1H2BJ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2BJ gene
    HIST1H2BK1 2  HIST1H2BN2  HIST1H2BD2  HIST1H2BC2  HIST1H2BE2  HIST1H2BB2  HIST1H2BM2  HIST3H2BB2  
    HIST1H2BI2  HIST1H2BG2  HIST1H2BH2  HIST2H2BF2  HIST1H2BL2  HIST1H2BO2  HIST1H2BF2  HIST2H2BE2  
    18/23 SIMAP similar genes for HIST1H2BJ using alignment to 1 protein entry:     H2B1J_HUMAN(see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH
    HIST1H2BI    HIST1H2BK    HIST1H2BM    HIST1H2BN    HIST1H2BO    HIST2H2BE
    HIST2H2BF    HIST3H2BB    HIST1H2BC    H2BFS    HIST1H2BL    ABCF2

    HIST1H2BJ for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HIST1H2BJ
    PGOHUM00000237729


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/13 SNPs in HIST1H2BJ are shown (see all 13)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1915856211,2
    --27101854(+) CCTGAA/TGGATA 1 -- us2k10--------
    rs1165922831,2
    F--27101868(+) GTGAAG/ACATTC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs737395981,2
    C,F--27101891(+) TACTGC/GATGTT 1 -- us2k13Minor allele frequency- G:0.06WA CSA 122
    rs1823916621,2
    --27102012(+) AAGAAA/CTTGAC 1 -- us2k10--------
    rs1494327011,2
    C--27102108(+) AGATAG/TGAGGG 1 -- us2k10--------
    rs1137720821,2
    C--27102210(+) AAAAGT/-TACAG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1878816711,2
    --27102263(+) ACTGGC/GAGTTT 1 -- us2k10--------
    rs1930486641,2
    --27102282(+) GGAGGG/TTTATT 1 -- us2k10--------
    rs1847653361,2
    --27102339(+) ATACTC/GATGCC 1 -- us2k10--------
    rs717083691,2
    ----27102410(+) TTTTT-/TGAGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2BJ (27093676 - 27100575 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HIST1H2BJ: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2BJ
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2BJ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615044    OMIM disorders: --

    3 diseases for HIST1H2BJ:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    schizophrenia


    HIST1H2BJ for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIST1H2BJ
    Human Genome Epidemiology (HuGE) Navigator: HIST1H2BJ (1 document)

    Export disorders for HIST1H2BJ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2BJ gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with HIST1H2BJ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The primary structure and expression of four cloned human histone genes. (PubMed id 6647026)1, 2, 3 Zhong R.... Heintz N. (1983)
    3. Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (PubMed id 19084217)1, 4 Benyamin B....Visscher P.M. (2009)
    4. Common variants on chromosome 6p22.1 are associated w ith schizophrenia. (PubMed id 19571809)1, 4 Shi J....Gejman P.V. (2009)
    5. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    6. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (2006)
    7. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (2005)
    8. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    9. Antimicrobial peptides in the first line defence of human colon mucosa. (PubMed id 12860195)1, 2 Tollin M....Agerberth B. (2003)
    10. Antimicrobial polypeptides of the human colonic epithelium. (PubMed id 15019208)1, 2 Howell S.J.... Bevins C.L. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8970 HGNC: 4761 AceView: HIST1H2BJandHIST1H2BK Ensembl:ENSG00000124635 euGenes: HUgn8970
    ECgene: HIST1H2BJ Kegg: 8970 H-InvDB: HIST1H2BJ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2BJ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H2BJ gene:
    Search GeneIP for patents involving HIST1H2BJ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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