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Aliases for HIST1H2BJ Gene

Aliases for HIST1H2BJ Gene

  • Histone Cluster 1, H2bj 2 3 5
  • H2B Histone Family, Member R 2 3
  • Histone 1, H2bj 2 3
  • Histone H2B.1 3 4
  • Histone H2B.R 3 4
  • H2BFR 3 4
  • H2B/R 3 4
  • H2BJ 3

External Ids for HIST1H2BJ Gene

Previous HGNC Symbols for HIST1H2BJ Gene

  • H2BFR

Previous GeneCards Identifiers for HIST1H2BJ Gene

  • GC06M027158
  • GC06M027208
  • GC06M027100
  • GC06M026910
  • GC06M027096

Summaries for HIST1H2BJ Gene

Entrez Gene Summary for HIST1H2BJ Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BJ Gene

HIST1H2BJ (Histone Cluster 1, H2bj) is a Protein Coding gene. Among its related pathways are Chromatin organization and Packaging Of Telomere Ends. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BH.

UniProtKB/Swiss-Prot for HIST1H2BJ Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Wiki entry for HIST1H2BJ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BJ Gene

Genomics for HIST1H2BJ Gene

Regulatory Elements for HIST1H2BJ Gene


Promoters for HIST1H2BJ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H2BJ on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H2BJ Gene

Chromosome:
6
Start:
27,125,897 bp from pter
End:
27,132,796 bp from pter
Size:
6,900 bases
Orientation:
Minus strand

Genomic View for HIST1H2BJ Gene

Genes around HIST1H2BJ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2BJ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2BJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BJ Gene

Proteins for HIST1H2BJ Gene

  • Protein details for HIST1H2BJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06899-H2B1J_HUMAN
    Recommended name:
    Histone H2B type 1-J
    Protein Accession:
    P06899
    Secondary Accessions:
    • B2R4J4
    • O60816

    Protein attributes for HIST1H2BJ Gene

    Size:
    126 amino acids
    Molecular mass:
    13904 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2BJ Gene

neXtProt entry for HIST1H2BJ Gene

Proteomics data for HIST1H2BJ Gene at MOPED

Post-translational modifications for HIST1H2BJ Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BJ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BJ Gene

Domains & Families for HIST1H2BJ Gene

Gene Families for HIST1H2BJ Gene

Protein Domains for HIST1H2BJ Gene

Suggested Antigen Peptide Sequences for HIST1H2BJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P06899

UniProtKB/Swiss-Prot:

H2B1J_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BJ: view

Function for HIST1H2BJ Gene

Molecular function for HIST1H2BJ Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
genes like me logo Genes that share phenotypes with HIST1H2BJ: view

Animal Models for HIST1H2BJ Gene

MGI Knock Outs for HIST1H2BJ:

Animal Model Products

miRNA for HIST1H2BJ Gene

miRTarBase miRNAs that target HIST1H2BJ

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIST1H2BJ Gene

Localization for HIST1H2BJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BJ Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BJ Gene COMPARTMENTS Subcellular localization image for HIST1H2BJ gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2BJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HIST1H2BJ: view

Pathways & Interactions for HIST1H2BJ Gene

SuperPathways for HIST1H2BJ Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Packaging Of Telomere Ends
genes like me logo Genes that share pathways with HIST1H2BJ: view

Gene Ontology (GO) - Biological Process for HIST1H2BJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019731 antibacterial humoral response IDA 12860195
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with HIST1H2BJ: view

No data available for SIGNOR curated interactions for HIST1H2BJ Gene

Drugs & Compounds for HIST1H2BJ Gene

No Compound Related Data Available

Transcripts for HIST1H2BJ Gene

mRNA/cDNA for HIST1H2BJ Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(253) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2BJ Gene

Histone cluster 1, H2bj:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BJ Gene

No ASD Table

Relevant External Links for HIST1H2BJ Gene

GeneLoc Exon Structure for
HIST1H2BJ
ECgene alternative splicing isoforms for
HIST1H2BJ

Expression for HIST1H2BJ Gene

mRNA expression in normal human tissues for HIST1H2BJ Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2BJ Gene

This gene is overexpressed in Whole Blood (x11.1) and Testis (x7.0).

Protein differential expression in normal tissues from HIPED for HIST1H2BJ Gene

This gene is overexpressed in Saliva (56.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIST1H2BJ Gene



SOURCE GeneReport for Unigene cluster for HIST1H2BJ Gene Hs.656567

genes like me logo Genes that share expression patterns with HIST1H2BJ: view

Protein tissue co-expression partners for HIST1H2BJ Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST1H2BJ Gene

Orthologs for HIST1H2BJ Gene

This gene was present in the common ancestor of animals.

Orthologs for HIST1H2BJ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC522960 35
  • 91.01 (n)
  • 99.21 (a)
HIST1H2BJ 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC488288 35
  • 92.59 (n)
  • 100 (a)
HIST1H2BJ 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist2h2be 35
  • 86.51 (n)
  • 97.62 (a)
Hist2h2be 16
Hist2h2be 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BK 35
  • 98.94 (n)
  • 100 (a)
HIST1H2BJ 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hist2h2be 35
  • 85.45 (n)
  • 97.62 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 99 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 82 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487485 35
  • 85.98 (n)
  • 94.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ano9a 36
  • 87 (a)
ManyToMany
ano9a 36
  • 94 (a)
ManyToMany
CABZ01086354.1 36
  • 86 (a)
ManyToMany
si:dkey-261m9.19 36
  • 86 (a)
ManyToMany
si:dkey-261m9.6 36
  • 86 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 87 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 94 (a)
ManyToMany
wu:fe11b02 36
  • 94 (a)
ManyToMany
wu:fe11b02 36
  • 88 (a)
ManyToMany
wu:fe11b02 36
  • 86 (a)
ManyToMany
zgc:112234 36
  • 86 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:112234 36
  • 94 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 86 (a)
ManyToMany
zgc:171759 36
  • 93 (a)
ManyToMany
zgc:171759 36
  • 47 (a)
ManyToMany
zgc:171759 36
  • 86 (a)
ManyToMany
zgc:171759 36
  • 85 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 87 (a)
ManyToMany
zgc:171759 36
  • 89 (a)
ManyToMany
zgc:171759 36
  • 89 (a)
ManyToMany
zgc:173587 36
  • 86 (a)
ManyToMany
zgc:194989 36
  • 93 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta H2B_ANOGA_e 35
  • 76.23 (n)
  • 81.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta His2B:CG33872 35
  • 76.11 (n)
  • 86.67 (a)
worm
(Caenorhabditis elegans)
Secernentea his-54 35
  • 69.59 (n)
  • 83.33 (a)
Species with no ortholog for HIST1H2BJ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIST1H2BJ Gene

ENSEMBL:
Gene Tree for HIST1H2BJ (if available)
TreeFam:
Gene Tree for HIST1H2BJ (if available)

Paralogs for HIST1H2BJ Gene

Pseudogenes.org Pseudogenes for HIST1H2BJ Gene

genes like me logo Genes that share paralogs with HIST1H2BJ: view

Variants for HIST1H2BJ Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BJ Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs113772082 -- 27,134,431(+) AAAAG(-/T)TACAG upstream-variant-2KB
rs73739598 -- 27,134,112(+) TACTG(C/G)ATGTT upstream-variant-2KB
rs182391662 -- 27,134,233(+) AAGAA(A/C)TTGAC upstream-variant-2KB
rs116592283 -- 27,134,089(+) GTGAA(A/G)CATTC upstream-variant-2KB
rs527681532 -- 27,134,676(+) TGGCG(C/T)TATCT upstream-variant-2KB

Variation tolerance for HIST1H2BJ Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for HIST1H2BJ Gene

Disorders for HIST1H2BJ Gene

Relevant External Links for HIST1H2BJ

Genetic Association Database (GAD)
HIST1H2BJ
Human Genome Epidemiology (HuGE) Navigator
HIST1H2BJ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2BJ

No disorders were found for HIST1H2BJ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BJ Gene

Publications for HIST1H2BJ Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. The primary structure and expression of four cloned human histone genes. (PMID: 6647026) Zhong R. … Heintz N. (Nucleic Acids Res. 1983) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HIST1H2BJ Gene

Sources for HIST1H2BJ Gene

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