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Aliases for HIST1H2BH Gene

Aliases for HIST1H2BH Gene

  • Histone Cluster 1, H2bh 2 3
  • H2BFJ 3 4 6
  • H2B Histone Family, Member J 2 3
  • Histone 1, H2bh 2 3
  • Histone H2B.J 3 4
  • H2B/J 3 4
  • Histone H2B Type 1-H 3

External Ids for HIST1H2BH Gene

Previous HGNC Symbols for HIST1H2BH Gene

  • H2BFJ

Previous GeneCards Identifiers for HIST1H2BH Gene

  • GC06P026309
  • GC06P026359
  • GC06P026194

Summaries for HIST1H2BH Gene

Entrez Gene Summary for HIST1H2BH Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2BH Gene

HIST1H2BH (Histone Cluster 1, H2bh) is a Protein Coding gene. Diseases associated with HIST1H2BH include hiv-1. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for HIST1H2BH Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2BH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BH Gene

Genomics for HIST1H2BH Gene

Regulatory Elements for HIST1H2BH Gene

Genomic Location for HIST1H2BH Gene

Start:
26,251,651 bp from pter
End:
26,252,075 bp from pter
Size:
425 bases
Orientation:
Plus strand

Genomic View for HIST1H2BH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2BH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BH Gene

Proteins for HIST1H2BH Gene

  • Protein details for HIST1H2BH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93079-H2B1H_HUMAN
    Recommended name:
    Histone H2B type 1-H
    Protein Accession:
    Q93079
    Secondary Accessions:
    • B2R541
    • Q4VB74

    Protein attributes for HIST1H2BH Gene

    Size:
    126 amino acids
    Molecular mass:
    13892 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

neXtProt entry for HIST1H2BH Gene

Proteomics data for HIST1H2BH Gene at MOPED

Post-translational modifications for HIST1H2BH Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys44, Lys47, Lys58, Lys109, Lys117, and Lys121
  • Glycosylation at Ser113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BH Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST1H2BH Gene

Domains for HIST1H2BH Gene

Gene Families for HIST1H2BH Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2BH Gene

Suggested Antigen Peptide Sequences for HIST1H2BH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93079

UniProtKB/Swiss-Prot:

H2B1H_HUMAN :
  • Q93079
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BH: view

Function for HIST1H2BH Gene

Molecular function for HIST1H2BH Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2BH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 9119399
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BH: view

miRNA for HIST1H2BH Gene

miRTarBase miRNAs that target HIST1H2BH

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2BH
    • Block miRNA regulation of HIST1H2BH using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BH

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2BH Gene

    Localization for HIST1H2BH Gene

    Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BH Gene

    Nucleus. Chromosome.

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for HIST1H2BH Gene COMPARTMENTS Subcellular localization image for HIST1H2BH gene
    Compartment Confidence
    nucleus 5
    cytosol 1
    plasma membrane 1

    Gene Ontology (GO) - Cellular Components for HIST1H2BH Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0000786 nucleosome NAS 9119399
    GO:0000788 nuclear nucleosome IBA --
    GO:0005622 intracellular --
    GO:0005634 nucleus IDA 16319397
    GO:0005654 nucleoplasm TAS --
    genes like me logo Genes that share ontologies with HIST1H2BH: view

    Pathways for HIST1H2BH Gene

    genes like me logo Genes that share pathways with HIST1H2BH: view

    Pathways by source for HIST1H2BH Gene

    29 Reactome pathways for HIST1H2BH Gene
    3 KEGG pathways for HIST1H2BH Gene
    1 GeneGo (Thomson Reuters) pathway for HIST1H2BH Gene

    Interacting Proteins for HIST1H2BH Gene

    Selected Interacting proteins: Q93079-H2B1H_HUMAN for HIST1H2BH Gene via I2D

    Gene Ontology (GO) - Biological Process for HIST1H2BH Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0006325 chromatin organization TAS --
    GO:0006334 nucleosome assembly NAS 9119399
    genes like me logo Genes that share ontologies with HIST1H2BH: view

    Transcripts for HIST1H2BH Gene

    mRNA/cDNA for HIST1H2BH Gene

    (6) Additional mRNA sequences :
    (1) REFSEQ mRNAs :
    (6) Selected AceView cDNA sequences:
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for HIST1H2BH Gene

    Histone cluster 1, H2bh:
    Representative Sequences:

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2BH
      • Block miRNA regulation of HIST1H2BH using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2BH

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST1H2BH
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BH Gene

      No ASD Table

      Relevant External Links for HIST1H2BH Gene

      GeneLoc Exon Structure for
      HIST1H2BH
      ECgene alternative splicing isoforms for
      HIST1H2BH

      Expression for HIST1H2BH Gene

      mRNA expression in normal human tissues for HIST1H2BH Gene

      mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

      mRNA differential expression in normal tissues according to GTEx for HIST1H2BH Gene

      This gene is overexpressed in Whole Blood (6.5) and Esophagus - Mucosa (5.2).

      Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HIST1H2BH Gene

      SOURCE GeneReport for Unigene cluster for HIST1H2BH Gene Hs.247815

      genes like me logo Genes that share expressions with HIST1H2BH: view

      In Situ Assay Products

      No data available for mRNA Expression by UniProt/SwissProt for HIST1H2BH Gene

      Orthologs for HIST1H2BH Gene

      This gene was present in the common ancestor of eukaryotes.

      Orthologs for HIST1H2BH Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia LOC463172 35
      • 98.94 (n)
      • 100 (a)
      cow
      (Bos Taurus)
      Mammalia HIST2H2BF 35
      • 84.8 (n)
      • 99.2 (a)
      dog
      (Canis familiaris)
      Mammalia LOC483164 35
      • 90.21 (n)
      • 99.21 (a)
      mouse
      (Mus musculus)
      Mammalia Hist1h2bh 16
      Hist1h2bq 35
      • 91.2 (n)
      • 98.4 (a)
      rat
      (Rattus norvegicus)
      Mammalia LOC100359692 35
      • 89.15 (n)
      • 97.62 (a)
      A. gosspyii yeast
      (Ashbya gossypii)
      Saccharomycetes AGOS_AGR183C 35
      • 69.97 (n)
      • 71.9 (a)
      baker's yeast
      (Saccharomyces cerevisiae)
      Saccharomycetes HTB2 35
      • 64.43 (n)
      • 75.63 (a)
      K. lactis yeast
      (Kluyveromyces lactis)
      Saccharomycetes KLLA0F13310g 35
      • 61.43 (n)
      • 71.07 (a)
      thale cress
      (Arabidopsis thaliana)
      eudicotyledons AT3G53650 35
      • 65.83 (n)
      • 73.33 (a)
      rice
      (Oryza sativa)
      Liliopsida Os01g0153100 35
      • 74.84 (n)
      • 74.51 (a)
      bread mold
      (Neurospora crassa)
      Ascomycetes NCU02435 35
      • 69.42 (n)
      • 72.73 (a)
      fission yeast
      (Schizosaccharomyces pombe)
      Schizosaccharomycetes htb1 35
      • 65.84 (n)
      • 71.07 (a)
      Species with no ortholog for HIST1H2BH:
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for HIST1H2BH Gene

      ENSEMBL:
      Gene Tree for HIST1H2BH (if available)
      TreeFam:
      Gene Tree for HIST1H2BH (if available)

      Paralogs for HIST1H2BH Gene

      genes like me logo Genes that share paralogs with HIST1H2BH: view

      No data available for Paralogs for HIST1H2BH Gene

      Variants for HIST1H2BH Gene

      Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BH Gene

      Variant ID Type Subtype PubMed ID
      nsv428137 CNV Loss 18775914

      Relevant External Links for HIST1H2BH Gene

      HapMap Linkage Disequilibrium report
      HIST1H2BH

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HIST1H2BH Gene

      Disorders for HIST1H2BH Gene

      MalaCards: The human disease database

      MalaCards: The human disease database. (1) Diseases for HIST1H2BH Gene including...

      Search for HIST1H2BH Gene in MalaCards »

      Relevant External Links for HIST1H2BH

      Genetic Association Database (GAD)
      HIST1H2BH
      genes like me logo Genes that share disorders with HIST1H2BH: view

      No data available for UniProtKB/Swiss-Prot for HIST1H2BH Gene

      Publications for HIST1H2BH Gene

      1. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4
      2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
      3. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PMID: 12757711) Cheung W.L. … Allis C.D. (Cell 2003) 3 4
      4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
      5. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4

      Products for HIST1H2BH Gene

      Sources for HIST1H2BH Gene

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