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Aliases for HIST1H2BE Gene

Aliases for HIST1H2BE Gene

  • Histone Cluster 1, H2be 2 3 5
  • H2B Histone Family, Member H 2 3
  • Histone H2B.1 A 3 4
  • Histone 1, H2be 2 3
  • Histone H2B.H 3 4
  • H2B/H 3 4
  • H2BFH 3 4
  • HIST1H2BC HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BI 4
  • Histone H2B.A 4
  • Histone H2B.G 4
  • Histone H2B.K 4
  • Histone H2B.L 4
  • DJ221C16.8 3
  • H2BFL 4
  • H2B/L 4
  • H2B/A 4
  • H2B/G 4
  • H2B/K 4
  • H2BFA 4
  • H2BFG 4
  • H2BFK 4
  • H2B.H 3

External Ids for HIST1H2BE Gene

Previous HGNC Symbols for HIST1H2BE Gene

  • H2BFH

Previous GeneCards Identifiers for HIST1H2BE Gene

  • GC06P026241
  • GC06P026292
  • GC06P026183
  • GC06P026127

Summaries for HIST1H2BE Gene

Entrez Gene Summary for HIST1H2BE Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BE Gene

HIST1H2BE (Histone Cluster 1, H2be) is a Protein Coding gene. Among its related pathways are Chromatin organization and Packaging Of Telomere Ends. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is H2BFWT.

UniProtKB/Swiss-Prot for HIST1H2BE Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

  • Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Gene Wiki entry for HIST1H2BE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BE Gene

Genomics for HIST1H2BE Gene

Regulatory Elements for HIST1H2BE Gene

Enhancers for HIST1H2BE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIST1H2BE on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H2BE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H2BE on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H2BE Gene

Chromosome:
6
Start:
26,172,059 bp from pter
End:
26,184,655 bp from pter
Size:
12,597 bases
Orientation:
Plus strand

Genomic View for HIST1H2BE Gene

Genes around HIST1H2BE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2BE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2BE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BE Gene

Proteins for HIST1H2BE Gene

  • Protein details for HIST1H2BE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62807-H2B1C_HUMAN
    Recommended name:
    Histone H2B type 1-C/E/F/G/I
    Protein Accession:
    P62807
    Secondary Accessions:
    • P02278
    • Q3B872
    • Q4VB69
    • Q93078
    • Q93080

    Protein attributes for HIST1H2BE Gene

    Size:
    126 amino acids
    Molecular mass:
    13906 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for HIST1H2BE Gene

Proteomics data for HIST1H2BE Gene at MOPED

Post-translational modifications for HIST1H2BE Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BE Gene

Domains & Families for HIST1H2BE Gene

Gene Families for HIST1H2BE Gene

Protein Domains for HIST1H2BE Gene

Graphical View of Domain Structure for InterPro Entry

P62807

UniProtKB/Swiss-Prot:

H2B1C_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BE: view

No data available for Suggested Antigen Peptide Sequences for HIST1H2BE Gene

Function for HIST1H2BE Gene

Molecular function for HIST1H2BE Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniProtKB/Swiss-Prot Function:
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BE Gene

Localization for HIST1H2BE Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BE Gene COMPARTMENTS Subcellular localization image for HIST1H2BE gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2BE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HIST1H2BE: view

Pathways & Interactions for HIST1H2BE Gene

SuperPathways for HIST1H2BE Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Packaging Of Telomere Ends
genes like me logo Genes that share pathways with HIST1H2BE: view

Gene Ontology (GO) - Biological Process for HIST1H2BE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019731 antibacterial humoral response IDA 12860195
GO:0050830 defense response to Gram-positive bacterium IDA 12860195
genes like me logo Genes that share ontologies with HIST1H2BE: view

No data available for SIGNOR curated interactions for HIST1H2BE Gene

Drugs & Compounds for HIST1H2BE Gene

No Compound Related Data Available

Transcripts for HIST1H2BE Gene

mRNA/cDNA for HIST1H2BE Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2BE Gene

Histone cluster 1, H2be:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BE Gene

No ASD Table

Relevant External Links for HIST1H2BE Gene

GeneLoc Exon Structure for
HIST1H2BE
ECgene alternative splicing isoforms for
HIST1H2BE

Expression for HIST1H2BE Gene

mRNA expression in normal human tissues for HIST1H2BE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2BE Gene

This gene is overexpressed in Whole Blood (x6.3) and Cervix - Ectocervix (x5.8).

Protein differential expression in normal tissues from HIPED for HIST1H2BE Gene

This gene is overexpressed in Tlymphocyte (13.3), Ovary (12.8), Monocytes (11.3), Blymphocyte (6.7), Liver, secretome (6.5), and Neutrophil (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HIST1H2BE Gene



SOURCE GeneReport for Unigene cluster for HIST1H2BE Gene Hs.534369

genes like me logo Genes that share expression patterns with HIST1H2BE: view

Protein tissue co-expression partners for HIST1H2BE Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H2BE Gene

Orthologs for HIST1H2BE Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2BE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIST1H2BL 35
  • 89.95 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia LOC100856116 35
  • 92.86 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hist1h2bl 35
  • 93.12 (n)
  • 99.21 (a)
Hist1h2bl 16
chimpanzee
(Pan troglodytes)
Mammalia LOC471883 35
  • 89.68 (n)
  • 100 (a)
Species with no ortholog for HIST1H2BE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2BE Gene

ENSEMBL:
Gene Tree for HIST1H2BE (if available)
TreeFam:
Gene Tree for HIST1H2BE (if available)

Paralogs for HIST1H2BE Gene

Paralogs for HIST1H2BE Gene

genes like me logo Genes that share paralogs with HIST1H2BE: view

Variants for HIST1H2BE Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BE Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11753084 -- 26,181,833(+) TCCCA(A/G)GTAGC upstream-variant-2KB
rs11757724 -- 26,181,863(+) CACCA(C/T)GCCCG upstream-variant-2KB
rs11760140 -- 26,181,821(+) TCTCC(C/T)TCAGC upstream-variant-2KB
rs7766641 -- 26,183,874(+) AGGAC(A/G)GCAAG reference, missense
rs16891375 -- 26,183,813(+) GCGAA(A/G)TCCGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BE Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914
dgv375n21 CNV Loss 19592680
nsv883490 CNV Loss 21882294

Variation tolerance for HIST1H2BE Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.80; 89.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2BE Gene

Human Gene Mutation Database (HGMD)
HIST1H2BE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BE Gene

Disorders for HIST1H2BE Gene

Relevant External Links for HIST1H2BE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2BE

No disorders were found for HIST1H2BE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BE Gene

Publications for HIST1H2BE Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for HIST1H2BE Gene

Sources for HIST1H2BE Gene

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