Aliases for HIST1H2BE Gene
Aliases for HIST1H2BE Gene
- Histone Cluster 1 H2B Family Member E 2 3 5
- H2B Histone Family, Member H 2 3
- Histone Cluster 1, H2be 2 3
- Histone H2B.1 A 3 4
- Histone 1, H2be 2 3
- Histone H2B.H 3 4
- H2B/H 3 4
- H2BFH 3 4
- HIST1H2BC HIST1H2BE HIST1H2BF HIST1H2BG HIST1H2BI 4
- Histone H2B Type 1-C/E/F/G/I 3
- Histone H2B.A 4
- Histone H2B.G 4
- Histone H2B.K 4
External Ids for HIST1H2BE Gene
- HGNC: 4753
- Entrez Gene: 8344
- Ensembl: ENSG00000274290
- OMIM: 602805
- UniProtKB: P62807
Previous HGNC Symbols for HIST1H2BE Gene
- H2BFH
Previous GeneCards Identifiers for HIST1H2BE Gene
- GC06P026241
- GC06P026292
- GC06P026183
- GC06P026127
- GC06P026213
- GC06P026372
- GC06P026468
Summaries for HIST1H2BE Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. The protein has antibacterial and antifungal antimicrobial activity. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H2BE Gene
HIST1H2BE (Histone Cluster 1 H2B Family Member E) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BF.
UniProtKB/Swiss-Prot for HIST1H2BE Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
-
Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BE Gene
Genomics for HIST1H2BE Gene
Regulatory Elements for HIST1H2BE Gene
Enhancers for HIST1H2BE Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H2BE on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST1H2BE gene promoter:
Regulatory Element Products
Genomic Location for HIST1H2BE Gene
- Chromosome:
- 6
- Start:
- 26,172,059 bp from pter
- End:
- 26,184,655 bp from pter
- Size:
- 12,597 bases
- Orientation:
- Plus strand
Genomic View for HIST1H2BE Gene
Genes around HIST1H2BE on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H2BE Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H2BE Gene
Proteins for HIST1H2BE Gene
-
Protein details for HIST1H2BE Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62807-H2B1C_HUMAN
- Recommended name:
- Histone H2B type 1-C/E/F/G/I
- Protein Accession:
- P62807
- P02278
- Q3B872
- Q4VB69
- Q93078
- Q93080
Protein attributes for HIST1H2BE Gene
- Size:
- 126 amino acids
- Molecular mass:
- 13906 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST1H2BE Gene
Post-translational modifications for HIST1H2BE Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes.
- Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- Ubiquitination at isoforms=121
- Glycosylation at isoforms=113
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H2BE Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST1H2BE Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H2BE
- Search GeneTex for Antibodies for HIST1H2BE
Protein Products
-
OriGene Purified Proteins for HIST1H2BE
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H2BE
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- Novus Biologicals lysates for HIST1H2BE
- Search GeneTex for Proteins for HIST1H2BE
Assay Products
No data available for DME Specific Peptides for HIST1H2BE Gene
Domains & Families for HIST1H2BE Gene
Gene Families for HIST1H2BE Gene
- HGNC:
Protein Domains for HIST1H2BE Gene
- InterPro:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P62807- Family:
-
- Belongs to the histone H2B family.
No data available for Suggested Antigen Peptide Sequences for HIST1H2BE Gene
Function for HIST1H2BE Gene
Molecular function for HIST1H2BE Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
- UniProtKB/Swiss-Prot Function:
- Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS,IBA | 422550 |
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H2BE Gene
- GenomeRNAi human phenotypes for HIST1H2BE:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2BE gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BE gene
- Search ViGene Biosciences for HIST1H2BE
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2BE
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BE
- GenScript: Design CRISPR guide RNA sequences for HIST1H2BE
miRNA for HIST1H2BE Gene
- miRTarBase miRNAs that target HIST1H2BE
-
- hsa-mir-34a-5p (MIRT025218)
- hsa-mir-98-5p (MIRT027455)
- hsa-mir-146a-3p (MIRT360268)
- hsa-mir-760 (MIRT360269)
- hsa-mir-1276 (MIRT360270)
- hsa-mir-3940-5p (MIRT360274)
- hsa-mir-4507 (MIRT360275)
- hsa-mir-6839-3p (MIRT360277)
- hsa-mir-8057 (MIRT360278)
- hsa-mir-5693 (MIRT511726)
- hsa-mir-3115 (MIRT511727)
- hsa-mir-4758-5p (MIRT511728)
- hsa-mir-1238-5p (MIRT511729)
- hsa-mir-299-5p (MIRT511730)
- hsa-mir-629-5p (MIRT511731)
- hsa-mir-6822-3p (MIRT511732)
- hsa-mir-4745-5p (MIRT511733)
- hsa-mir-4481 (MIRT511734)
- hsa-mir-4766-5p (MIRT511735)
miRNA Products
- Search ViGene Biosciences for HIST1H2BE
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H2BE
- Browse OriGene Inhibitory RNA Products For HIST1H2BE
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BE gene
Clone Products
-
OriGene ORF clones in human for HIST1H2BE
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
-
Horizon Cell Lines for HIST1H2BE
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H2BE gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2BE gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BE gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BE Gene
Localization for HIST1H2BE Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BE Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | NAS | 422550 |
| GO:0005615 | extracellular space | IDA | 12860195 |
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HIST1H2BE Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST1H2BE Gene
68 Reactome pathways for HIST1H2BE Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H2BE Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2BE Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002227 | innate immune response in mucosa | IDA | 12860195 |
| GO:0006334 | nucleosome assembly | NAS | 422550 |
| GO:0016567 | protein ubiquitination | TAS | -- |
| GO:0019731 | antibacterial humoral response | IDA | 12860195 |
| GO:0042742 | defense response to bacterium | IEA | -- |
No data available for SIGNOR curated interactions for HIST1H2BE Gene
Transcripts for HIST1H2BE Gene
mRNA/cDNA for HIST1H2BE Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H2BE Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2BE
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BE
- GenScript: Design CRISPR guide RNA sequences for HIST1H2BE
miRNA Products
- Search ViGene Biosciences for HIST1H2BE
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H2BE
- Browse OriGene Inhibitory RNA Products For HIST1H2BE
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BE gene
Clone Products
-
OriGene ORF clones in human for HIST1H2BE
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H2BE Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Kidney (Urinary System)
- Presumptive Podocytes Podocyte Layer
-
Epithelial Cells
- Presumptive Podocytes Podocyte Layer
-
Heart (Cardiovascular System)
- Cardiac Fibroblasts Myocardium
-
Fibroblasts
- Cardiac Fibroblasts Myocardium
mRNA differential expression in normal tissues according to GTEx for HIST1H2BE Gene
This gene is overexpressed in Whole Blood (x6.3) and Cervix - Ectocervix (x5.8).
This gene is overexpressed in Tlymphocyte (13.3), Ovary (12.8), Monocytes (11.3), Blymphocyte (6.7), Liver, secretome (6.5), and Neutrophil (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for HIST1H2BE Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HIST1H2BE Gene:
HIST1H2BESOURCE GeneReport for Unigene cluster for HIST1H2BE Gene:
Hs.534369Evidence on tissue expression from TISSUES for HIST1H2BE Gene
- Lung(4.2)
- Spleen(4.2)
Primer Products
-
OriGene qPCR primer pairs for HIST1H2BE
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2BE Gene
Orthologs for HIST1H2BE Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Hist1h2bl 34 16 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC100856116 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HIST1H2BL 34 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | LOC471883 34 |
|
- Species where no ortholog for HIST1H2BE was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIST1H2BE Gene
Paralogs for HIST1H2BE Gene
(21) SIMAP similar genes for HIST1H2BE Gene using alignment to 1 proteins:
Variants for HIST1H2BE Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1002852454 | -- | 26,182,959(+) | AGTCA(A/C)ATTTA | upstream-variant-2KB | |
| rs1002911379 | -- | 26,183,954(+) | GACAC(C/T)GGCAT | reference, synonymous-codon | |
| rs1005520740 | -- | 26,184,464(+) | AAAAT(A/G)CGGGT | downstream-variant-500B | |
| rs1007404959 | -- | 26,181,973(+) | GTGTT(C/G)GGATT | upstream-variant-2KB | |
| rs1007478573 | -- | 26,182,538(+) | AACTC(-/CT)GCCCT | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv375n21 | CNV | loss | 19592680 |
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv970084 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.80;
89.52% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H2BE Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BE Gene
Disorders for HIST1H2BE Gene
Relevant External Links for HIST1H2BE
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H2BE
No disorders were found for HIST1H2BE Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BE Gene
Publications for HIST1H2BE Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4 64
- Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck H.C. … Jensen O.N. (Mol. Cell. Proteomics 2006) 3 4 64
- Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R. … Reinberg D. (Cell 2006) 3 4 64
- Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4 64
Products for HIST1H2BE Gene
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H2BE Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer