Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2BD Gene

protein-coding   GIFtS: 53
GCID: GC06P026158

histone cluster 1, H2bd

(Previous names: H2B histone family, member B, histone 1, H2bd )
(Previous symbol: H2BFB)
 Explore 3 diseases affiliated with
HIST1H2BD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H2BD    

Aliases
for HIST1H2BD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H2bd1 2     Histone H2B.B2 3
H2BFB1 2 3 5     HIRIP22 3
H2B/B1     HIRA-Interacting Protein 22 3
H2B Histone Family, Member B1 2     H2B.1B2
Histone 1, H2bd1 2     DJ221C16.61
Histone H2B.1 B2 3     Histone H2B Type 1-D2

External Ids:    HGNC: 47471   Entrez Gene: 30172   Ensembl: ENSG000001583737   OMIM: 6027995   UniProtKB: P588763   

Export aliases for HIST1H2BD gene to outside databases

Previous GC identifers: GC06P026217 GC06P026266 GC06P026102


Summaries
for HIST1H2BD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H2BD:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of
each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode the same protein
have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2B1D_HUMAN, P58876
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2BD


Genomic Views
for HIST1H2BD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2BD gene promoter:
         AML1a   Lmo2   MIF-1   CREB   Pax-3   HSF2   Msx-1   TGIF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H2BD promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2BD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2BD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BD gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026158:  view genomic region     (about GC identifiers)

Start:
 26,158,349 bp from pter      End:
 26,171,577 bp from pter
Size:
 13,229 bases      Orientation:
 plus strand

Proteins
for HIST1H2BD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2B1D_HUMAN, P58876 (See protein sequence)
Recommended Name: Histone H2B type 1-D  
Size: 126 amino acids; 13936 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Miscellaneous: The mouse orthologous protein seems not to exist

Explore the universe of human proteins at neXtProt for HIST1H2BD: NX_P58876

Post-translational modifications:

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79'
    • (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly,
    monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional
    activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively
    with the FACT dimer to stimulate elongation by RNA polymerase II1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    • Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation.
    Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic
    hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose,
    • and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P58876

    • HIST1H2BD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_066407.1  NP_619790.1  

    ENSEMBL proteins: 
     ENSP00000289316   ENSP00000367008  
    Reactome Protein details: P58876
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HIST1H2BD
    OriGene Custom Protein Services for HIST1H2BD 
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H2BD
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H2BD

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--


    HIST1H2BD for ontologies           About GeneDecksing



    HIST1H2BD Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H2BD
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST1H2BD 
    GenScript Custom Superior Antibodies Services for HIST1H2BD
    Search for Antibodies for HIST1H2BD at Abcam  
    Uscn Antibodies for HIST1H2BD
    Search ThermoFisher Antibodies for HIST1H2BD

    Assay Products for HIST1H2BD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H2BD
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIST1H2BD

    Protein Domains /
    Families
    for HIST1H2BD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H2BD for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P58876

    ProtoNet protein and cluster: P58876

    UniProtKB/Swiss-Prot: H2B1D_HUMAN, P58876
    Similarity: Belongs to the histone H2B family


    Function
    for HIST1H2BD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2B1D_HUMAN, P58876
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): HIST1H2BD
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H2BD
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H2BD:
    hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmid: HIST1H2BD 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2BD
    OriGene shRNA RFP: HIST1H2BD
    OriGene siRNA: HIST1H2BD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2BD

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HIST1H2BD

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2BD (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2BD (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HIST1H2BD (NM_021063)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2BD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BD 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HIST1H2BD
    Search LifeMap BioReagents cell lines for HIST1H2BD

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2BD

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--


    HIST1H2BD for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for HIST1H2BD:
     Increased G2M DNA content  Increased cell size 


    Pathways & Interactions
    for HIST1H2BD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Packaging Of Telomere Ends0.54
    		Telomere clustering at the nuclear membrane0.82
    		Telomere Maintenance0.38
    		Meiosis0.70
    		Meiotic Recombination0.32
    		Chromosome Maintenance0.56
    2RSF Complex Binds the Centromere.
    		RSF Complex Binds the Centromere.1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    		Nucleosome assembly1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    3Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    4Formation of Meiotic Holliday Junction
    		Formation of Meiotic Holliday Junction1.00
    		Formation of Meiotic Single-stranded DNA Invasion Complex0.83
    		Formation of Meiotic Heteroduplex0.83
    5Disease
    		Disease1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2BD
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2BD
        Signal transduction Activin A signaling regulation

    5/17        Reactome Pathways for HIST1H2BD (see all 17)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Disease


    1         Kegg Pathway  (Kegg details for HIST1H2BD):
        Systemic lupus erythematosus


    HIST1H2BD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2BD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/101 Interacting proteins for HIST1H2BD (P588762, 3 ENSP000002893164) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--


    HIST1H2BD for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H2BD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2BD
    Search CenterWatch for drugs/clinical trials and news about HIST1H2BD / H2B1D 

    Transcripts
    for HIST1H2BD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H2BD gene (2 alternative transcripts): 
    NM_021063.3  NM_138720.2  

    Unigene Cluster for HIST1H2BD:

    Histone cluster 1, H2bd
    Hs.591797  [show with all ESTs]
    Unigene Representative Sequence: BQ683489
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289316(uc003ngs.3) ENST00000377777(uc003ngr.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): HIST1H2BD
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H2BD
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H2BD:
    hsa-miR-1276
    SwitchGear 3'UTR luciferase reporter plasmid: HIST1H2BD 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2BD
    OriGene shRNA RFP: HIST1H2BD
    OriGene siRNA: HIST1H2BD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2BD
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2BD (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2BD (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HIST1H2BD (NM_021063)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2BD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BD 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H2BD
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BD

    Additional cDNA sequence: 

    AJ223353.1 AK292712.1 BC002842.2 BC096122.3 

    4 DOTS entries:

    DT.309199  DT.100813064  DT.92452714  DT.95367371 

    24/76 AceView cDNA sequences (see all 76):

    AI621027 BM993698 AA169623 AV648706 BM675070 NM_021063 BM713206 AV705700 
    BU688596 N49638 AI201415 BF437365 BC002842 BF438312 BF447981 CB241912 
    NM_138720 AI656000 AA557199 AW297515 BU675361 T27838 BU739144 BF684122 

    GeneLoc Exon Structure


    Expression
    for HIST1H2BD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2BD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACTACCTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST1H2BD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST1H2BD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2BD

    SOURCE GeneReport for Unigene cluster: Hs.591797
        SABiosciences Custom PCR Arrays for HIST1H2BD
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H2BD
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BD
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BD
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2BD

    Orthologs
    for HIST1H2BD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2BD gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4295581 histone H2B 5-like 84.92(n)
    92.86(a)    		   429558  XM_427116.2  XP_427116.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 8)    		 --
    		 94(a)
    94(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 GL343466.1(297869-298249)
    GL343252.1(1811547-1811927)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufe11b022 Transcribed sequence with strong similarity to protein more 85.92(n)    57060285 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G287201 histone H2B 59.38(n)
    72.27(a)    		   817421  NM_128433.3  NP_180440.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g01531001 hypothetical protein 71.71(n)
    70.59(a)    		   4324502  NM_001048586.2  NP_001042051.1 


    ENSEMBL Gene Tree for HIST1H2BD (if available)
    TreeFam Gene Tree for HIST1H2BD (if available) 

    Paralogs
    for HIST1H2BD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2BD gene
    HIST3H2BB2  HIST1H2BI2  HIST1H2BK2  HIST1H2BG2  HIST1H2BC2  HIST2H2BF2  HIST1H2BH2  HIST1H2BL2  
    HIST1H2BE2  HIST1H2BO2  HIST1H2BJ2  HIST1H2BB2  HIST1H2BF2  HIST2H2BE2  
    18/22 SIMAP similar genes for HIST1H2BD using alignment to 1 protein entry:     H2B1D_HUMAN(see all similar genes):
    HIST1H2BB    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH    HIST1H2BI
    HIST1H2BJ    HIST1H2BK    HIST1H2BM    HIST1H2BN    HIST1H2BO    HIST2H2BE
    HIST2H2BF    HIST3H2BB    HIST1H2BC    H2BFS    HIST1H2BL    HIST2H2BC

    HIST1H2BD for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H2BD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/264 NCBI SNPs in HIST1H2BD are shown (see all 264)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1914029561,2
    		--26157866(+) ACACTA/GCAGAA 2 -- us2k10--------
    rs1151069091,2
    		F,--26157889(+) CTTAAA/CTGTGG 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs757565161,2
    		C,--26157934(+) AACTGA/CCAGAC 2 -- us2k10--------
    rs58750891,2
    		C--26157942(+) GACTT-/GGGGGG 2 -- us2k1 tfbs3 trp31Minor allele frequency- G:0.00CSA 2
    rs1831664201,2
    		--26157961(+) TCCCAA/GTTAGC 2 -- us2k10--------
    rs1404559241,2
    		--26157977(+) TTCTGC/TATGCA 2 -- us2k10--------
    rs792135611,2
    		C,F,--26157994(+) CCCATA/GCTTTG 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1867412581,2
    		--26158033(+) CTAATC/GTGTTA 2 -- us2k10--------
    rs77498231,2
    		C,F,A,H,--26158079(+) TAAAAA/CAGTCG 2 -- us2k126Minor allele frequency- C:0.09NA NS EA CSA WA 2960
    rs1464969721,2
    		--26158126(+) GCTGTC/TTTGCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2BD (26158349 - 26171577 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HIST1H2BD
         1 CNV: 51865

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H2BD
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2BD

    Disorders / Diseases
    for HIST1H2BD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H2BD for disorders           About GeneDecksing

    OMIM gene information: 602799    OMIM disorders: --

    3 diseases for HIST1H2BD:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    immunodeficiency


    Export disorders for HIST1H2BD gene to outside databases

    Publications
    for HIST1H2BD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2BD gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with HIST1H2BD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2, 3 Albig W....Doenecke D. (1991)
    3. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2 Bonenfant D.... van Oostrum J. (2006)
    4. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    5. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (2006)
    6. Gene-specific characterization of human histone H2B by electron capture dissociation. (PubMed id 16457587)1, 2 Siuti N.... Pesavento J.J. (2006)
    7. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (2005)
    8. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)

    External Searches for HIST1H2BD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H2BD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3017 HGNC: 4747 AceView: HIST1H2BD Ensembl:ENSG00000158373 euGenes: HUgn3017
    ECgene: HIST1H2BD Kegg: 3017 H-InvDB: HIST1H2BD

    Other Databases showing HIST1H2BD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H2BD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2BD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H2BD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H2BD gene:
    Search GeneIP for patents involving HIST1H2BD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HIST1H2BD gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H2BD
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HIST1H2BD  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2BD   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H2BD  
     OriGene Protein Over-expression Lysate for HIST1H2BD   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HIST1H2BD   OriGene 3'-UTR Clone for HIST1H2BD  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2BD   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2BD  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST1H2BD   OriGene Custom Protein Services for HIST1H2BD  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST1H2BD
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H2BD
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BD
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2BD
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BD
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BD
     GenScript Custom Purified and Recombinant Proteins Services for HIST1H2BD GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H2BD
     GenScript Custom Assay Services for HIST1H2BD GenScript Custom Superior Antibodies Services for HIST1H2BD
     GenScript Custom overexpressing Cell Line Services for HIST1H2BD CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HIST1H2BD promoter
     Search Chromatin IP Primers for HIST1H2BD
     RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BD
     Search GNC Networks for HIST1H2BD
     SABiosciences Custom PCR Arrays for HIST1H2BD
     Search Tocris compounds for HIST1H2BD
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Search for Antibodies for HIST1H2BD at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HIST1H2BD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HIST1H2BD Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HIST1H2BD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2BD
     SwitchGear 3'UTR luciferase reporter plasmids for HIST1H2BD
     SwitchGear Promoter luciferase reporter plasmids for HIST1H2BD
     Search ThermoFisher Antibodies for HIST1H2BD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BD
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HIST1H2BD gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4