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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2BD Gene

protein-coding   GIFtS: 55
GCID: GC06P026158

Histone Cluster 1, H2bd

(Previous names: H2B histone family, member B, histone 1, H2bd)
(Previous symbol: H2BFB)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H2bd1 2     H2B/b2 3
H2BFB1 2 3 5     HIRIP22 3
H2B Histone Family, Member B1 2     HIRA-Interacting Protein 22 3
Histone 1, H2bd1 2     H2B.1B2
Histone H2B.1 B2 3     dJ221C16.62
Histone H2B.B2 3     Histone H2B Type 1-D2

External Ids:    HGNC: 47471   Entrez Gene: 30172   Ensembl: ENSG000001583737   OMIM: 6027995   UniProtKB: P588763   

Export aliases for HIST1H2BD gene to outside databases

Previous GC identifers: GC06P026217 GC06P026266 GC06P026102


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2BD Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H2B family. Two transcripts that encode
the same protein have been identified for this gene, which is found in the large histone gene cluster on
chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2BD Gene: 
HIST1H2BD (histone cluster 1, H2bd) is a protein-coding gene. Diseases associated with HIST1H2BD include systemic lupus erythematosus, and lupus erythematosus, and among its related super-pathways are Signal transduction Activin A signaling regulation and Telomere Maintenance. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot: H2B1D_HUMAN, P58876
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2BD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2BD gene promoter:
         AML1a   Lmo2   MIF-1   CREB   Pax-3   HSF2   Msx-1   TGIF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2BD promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2BD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2BD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BD gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026158:  view genomic region     (about GC identifiers)

Start:
26,158,349 bp from pter      End:
26,171,577 bp from pter
Size:
13,229 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H2B1D_HUMAN, P58876 (See protein sequence)
Recommended Name: Histone H2B type 1-D  
Size: 126 amino acids; 13936 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Miscellaneous: The mouse orthologous protein seems not to exist

Explore the universe of human proteins at neXtProt for HIST1H2BD: NX_P58876

Explore proteomics data for HIST1H2BD at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II
  • UniProtKB: Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination
  • UniProtKB: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes (By similarity)
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P58876

  • HIST1H2BD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H2BD Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_066407.1  NP_619790.1  

    ENSEMBL proteins: 
     ENSP00000289316   ENSP00000367008  
    Reactome Protein details: P58876
    Human Recombinant Protein Products for HIST1H2BD: 
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    Cloud-Clone Corp. Proteins for HIST1H2BD 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    HIST1H2BD for ontologies           About GeneDecksing



    HIST1H2BD Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P58876

    ProtoNet protein and cluster: P58876

    UniProtKB/Swiss-Prot: H2B1D_HUMAN, P58876
    Similarity: Belongs to the histone H2B family


    HIST1H2BD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B1D_HUMAN, P58876
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    HIST1H2BD for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HIST1H2BD:
     Increased G2M DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H2BD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST1H2BD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H2BD 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H2BD About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.56
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    Telomere Maintenance0.56
    Amyloids0.41
    Nucleosome assembly0.46
    3Meiotic Synapsis
    Meiotic Synapsis0.70
    Meiotic Recombination0.62
    Meiosis0.70
    Chromosome Maintenance0.56
    4Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    5Cell Cycle
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2BD
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2BD
        Signal transduction Activin A signaling regulation


    5/11        Reactome Pathways for HIST1H2BD (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST1H2BD):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H2BD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2BD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/101 Interacting proteins for HIST1H2BD (P588762, 3 ENSP000002893164) via UniProtKB, MINT, STRING, and/or I2D (see all 101)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    HIST1H2BD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2BD (H2B1D)

    Search CenterWatch for drugs/clinical trials and news about HIST1H2BD / H2B1D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H2BD gene (2 alternative transcripts): 
    NM_021063.3  NM_138720.2  

    Unigene Cluster for HIST1H2BD:

    Histone cluster 1, H2bd
    Hs.591797  [show with all ESTs]
    Unigene Representative Sequence: BQ683489
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000289316(uc003ngs.3) ENST00000377777(uc003ngr.3)
    miRNA
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    Additional mRNA sequence: 

    AJ223353.1 AK292712.1 BC002842.2 BC096122.3 

    4 DOTS entries:

    DT.309199  DT.100813064  DT.92452714  DT.95367371 

    24/76 AceView cDNA sequences (see all 76):

    BC002842 AV648706 BM675070 BF437365 AI621027 BF447981 CB241912 BM993698 
    AI201415 AV705700 NM_021063 AA169623 NM_138720 BF438312 BM713206 BU688596 
    N49638 T27838 BF684122 BG283093 BG338027 CB144080 BU677321 BU739144 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2BD expression in normal human tissues (normalized intensities)      HIST1H2BD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTACCTTT
    HIST1H2BD Expression
    About this image


    HIST1H2BD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...
     
     Blood (Hematopoietic System)
             cd34+ cells   
     
     Mesenchymal Stem Cells (Muscoskeletal System)
             Human Mesenchymal Stem Cells (hMSC)-1   
     
     Cartilage (Muscoskeletal System)
             Human Annulus Fibrosus Cells (HAFC)   
     
     Brain (Nervous System)
             Brain Pericytes   

    See HIST1H2BD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2BD

    SOURCE GeneReport for Unigene cluster: Hs.591797
        SABiosciences Custom PCR Arrays for HIST1H2BD
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2BD gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2bm1 histone cluster 1, H2bm 91.53(n)
    100(a)
      319186  NM_178200.1  NP_835507.1 
    chicken
    (Gallus gallus)
    Aves LOC4295581 histone H2B 5-like 84.92(n)
    92.86(a)
      429558  XM_427116.2  XP_427116.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufe11b022 Transcribed sequence with strong similarity to protein more 85.92(n)    57060285 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G287201 histone H2B 59.38(n)
    72.27(a)
      817421  NM_128433.3  NP_180440.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01531001 hypothetical protein 71.71(n)
    70.59(a)
      4324502  NM_001048586.2  NP_001042051.1 


    ENSEMBL Gene Tree for HIST1H2BD (if available)
    TreeFam Gene Tree for HIST1H2BD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2BD gene
    HIST1H2BN2  HIST1H2BC2  HIST1H2BE2  HIST1H2BB2  HIST1H2BM2  HIST3H2BB2  HIST1H2BK2  HIST1H2BI2  
    HIST1H2BG2  HIST2H2BF2  HIST1H2BH2  HIST1H2BL2  HIST1H2BO2  HIST1H2BJ2  HIST1H2BF2  HIST2H2BE2  
    18/23 SIMAP similar genes for HIST1H2BD using alignment to 1 protein entry:     H2B1D_HUMAN(see all similar genes):
    HIST1H2BB    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH    HIST1H2BI
    HIST1H2BJ    HIST1H2BK    HIST1H2BM    HIST1H2BN    HIST1H2BO    HIST2H2BE
    HIST2H2BF    HIST3H2BB    HIST1H2BC    H2BFS    HIST1H2BL    ABCF2

    HIST1H2BD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/330 SNPs in HIST1H2BD are shown (see all 330)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1914029561,2
    --26157866(+) ACACTA/GCAGAA 2 -- us2k10--------
    rs1151069091,2
    C,F--26157889(+) CTTAAA/CTGTGG 2 -- us2k11Minor allele frequency- C:0.02WA 118
    rs757565161,2
    C--26157934(+) AACTGA/CCAGAC 2 -- us2k10--------
    rs58750891,2
    C--26157942(+) GACTT-/GGGGGG 2 -- us2k1 tfbs3 trp31Minor allele frequency- G:0.00CSA 2
    rs58750911,2
    C--26157952(+) GGGGG-/G/GGG 
            
    ATGTC
    4 -- us2k1 cds1 tfbs3 trp31NA 2
    rs1831664201,2
    --26157961(+) TCCCAA/GTTAGC 2 -- us2k10--------
    rs1404559241,2
    --26157977(+) TTCTGC/TATGCA 2 -- us2k10--------
    rs792135611,2
    C,F--26157994(+) CCCATA/GCTTTG 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1867412581,2
    --26158033(+) CTAATC/GTGTTA 2 -- us2k10--------
    rs77498231,2
    C,F,A,H--26158079(+) TAAAAA/CAGTCG 2 -- us2k126Minor allele frequency- C:0.09NA NS EA CSA WA 2960

    HapMap Linkage Disequilibrium report for HIST1H2BD (26158349 - 26171577 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H2BD:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv375n21CNV Loss19592680
    nsv428137CNV Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602799    OMIM disorders: --

    2 diseases for HIST1H2BD:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus


    HIST1H2BD for disorders           About GeneDecksing


    Export disorders for HIST1H2BD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2BD gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with HIST1H2BD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2, 3 Albig W....Doenecke D. (1991)
    3. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2 Bonenfant D.... van Oostrum J. (2006)
    4. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    5. Quantitative proteomic analysis of post-translational modifications of human histones. (PubMed id 16627869)1, 2 Beck H.C.... Jensen O.N. (2006)
    6. Gene-specific characterization of human histone H2B by electron capture dissociation. (PubMed id 16457587)1, 2 Siuti N.... Pesavento J.J. (2006)
    7. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (2005)
    8. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3017 HGNC: 4747 AceView: HIST1H2BD Ensembl:ENSG00000158373 euGenes: HUgn3017
    ECgene: HIST1H2BD Kegg: 3017 H-InvDB: HIST1H2BD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2BD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H2BD gene:
    Search GeneIP for patents involving HIST1H2BD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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