Aliases for HIST1H2BD Gene
Aliases for HIST1H2BD Gene
External Ids for HIST1H2BD Gene
- HGNC: 4747
- Entrez Gene: 3017
- Ensembl: ENSG00000158373
- OMIM: 602799
- UniProtKB: P58876
Previous HGNC Symbols for HIST1H2BD Gene
- H2BFB
Previous GeneCards Identifiers for HIST1H2BD Gene
- GC06P026217
- GC06P026266
- GC06P026158
- GC06P026102
- GC06P026172
- GC06P026177
- GC06P026189
- GC06P026370
- GC06P026462
Summaries for HIST1H2BD Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Two transcripts that encode the same protein have been identified for this gene, which is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H2BD Gene
HIST1H2BD (Histone Cluster 1 H2B Family Member D) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BE.
UniProtKB/Swiss-Prot for HIST1H2BD Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BD Gene
Genomics for HIST1H2BD Gene
Regulatory Elements for HIST1H2BD Gene
Enhancers for HIST1H2BD Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H2BD on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST1H2BD gene promoter:
Regulatory Element Products
Genomic Location for HIST1H2BD Gene
- Chromosome:
- 6
- Start:
- 26,157,843 bp from pter
- End:
- 26,171,349 bp from pter
- Size:
- 13,507 bases
- Orientation:
- Plus strand
Genomic View for HIST1H2BD Gene
Genes around HIST1H2BD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H2BD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H2BD Gene
Proteins for HIST1H2BD Gene
-
Protein details for HIST1H2BD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P58876-H2B1D_HUMAN
- Recommended name:
- Histone H2B type 1-D
- Protein Accession:
- P58876
Protein attributes for HIST1H2BD Gene
- Size:
- 126 amino acids
- Molecular mass:
- 13936 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- Miscellaneous:
-
- The mouse orthologous protein seems not to exist.
Protein Expression for HIST1H2BD Gene
Post-translational modifications for HIST1H2BD Gene
- ADP-ribosylated on Ser-7 in response to DNA damage.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
- Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- Ubiquitination at isoforms=6 and posLast=121121
- Glycosylation at posLast=113113
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H2BD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H2BD
-
Abcam antibodies for HIST1H2BD
- Invitrogen Antibodies for HIST1H2BD
- antibodies-online Antibodies for HIST1H2BD: See all 18
- GeneTex HIST1H2BD antibody for HIST1H2BD
Protein Products
-
OriGene Purified Proteins for HIST1H2BD
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H2BD
- Origene Custom Protein Services for HIST1H2BD
- antibodies-online Proteins for HIST1H2BD: See all 3
- Search antibodies-online for peptides
- GeneTex Proteins for HIST1H2BD
Assay Products
No data available for DME Specific Peptides for HIST1H2BD Gene
Domains & Families for HIST1H2BD Gene
Gene Families for HIST1H2BD Gene
- HGNC:
Protein Domains for HIST1H2BD Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H2BD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P58876- Family:
-
- Belongs to the histone H2B family.
Function for HIST1H2BD Gene
Molecular function for HIST1H2BD Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003677 | DNA binding | IBA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H2BD Gene
- GenomeRNAi human phenotypes for HIST1H2BD:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2BD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BD gene
- Search ViGene Biosciences for HIST1H2BD
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2BD
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BD
- GenScript: Design CRISPR guide RNA sequences for HIST1H2BD
miRNA for HIST1H2BD Gene
- miRTarBase miRNAs that target HIST1H2BD
-
- hsa-mir-98-5p (MIRT027729)
- hsa-mir-744-5p (MIRT037473)
- hsa-mir-455-3p (MIRT037819)
- hsa-mir-296-3p (MIRT038347)
- hsa-mir-652-3p (MIRT039490)
- hsa-mir-615-3p (MIRT040221)
- hsa-mir-378a-3p (MIRT043903)
- hsa-mir-3140-3p (MIRT052660)
- hsa-mir-2054 (MIRT499975)
- hsa-mir-6780a-5p (MIRT499976)
- hsa-mir-6779-5p (MIRT499977)
- hsa-mir-3689c (MIRT499978)
- hsa-mir-3689b-3p (MIRT499979)
- hsa-mir-3689a-3p (MIRT499980)
- hsa-mir-30b-3p (MIRT499981)
- hsa-mir-1273h-5p (MIRT499982)
- hsa-mir-4451 (MIRT499983)
- hsa-mir-6799-5p (MIRT499984)
- hsa-mir-6883-5p (MIRT499985)
- hsa-mir-6785-5p (MIRT499986)
- hsa-mir-4728-5p (MIRT499987)
- hsa-mir-149-3p (MIRT499988)
- hsa-mir-7106-5p (MIRT499989)
- hsa-mir-6086 (MIRT499990)
- hsa-mir-377-5p (MIRT499991)
- hsa-mir-4458 (MIRT499992)
- hsa-mir-4500 (MIRT499993)
- hsa-let-7i-5p (MIRT499994)
- hsa-let-7g-5p (MIRT499995)
- hsa-let-7f-5p (MIRT499996)
- hsa-let-7e-5p (MIRT499997)
- hsa-let-7d-5p (MIRT499998)
- hsa-let-7c-5p (MIRT499999)
- hsa-let-7b-5p (MIRT500000)
- hsa-let-7a-5p (MIRT500001)
- hsa-mir-27b-5p (MIRT500002)
- hsa-mir-3192-5p (MIRT500003)
- hsa-mir-556-5p (MIRT500004)
- hsa-mir-6831-5p (MIRT500005)
- hsa-mir-3927-3p (MIRT500006)
- hsa-mir-7851-3p (MIRT500007)
- hsa-mir-490-3p (MIRT500008)
- hsa-mir-6805-3p (MIRT531221)
- hsa-mir-5691 (MIRT531222)
- hsa-mir-676-5p (MIRT531223)
- hsa-mir-4264 (MIRT531224)
- hsa-mir-4797-3p (MIRT531225)
- hsa-mir-622 (MIRT531226)
- hsa-mir-4698 (MIRT531227)
- hsa-mir-8063 (MIRT531228)
- hsa-mir-4282 (MIRT531229)
- hsa-mir-3978 (MIRT545192)
- hsa-mir-8078 (MIRT545193)
- hsa-mir-3935 (MIRT545194)
- hsa-mir-1287-5p (MIRT545195)
- hsa-mir-3135b (MIRT545196)
- hsa-mir-875-3p (MIRT545197)
- hsa-mir-196b-5p (MIRT545198)
- hsa-mir-196a-5p (MIRT545199)
- hsa-mir-576-3p (MIRT545200)
- hsa-mir-4796-3p (MIRT545201)
- hsa-mir-93-5p (MIRT545202)
- hsa-mir-526b-3p (MIRT545203)
- hsa-mir-519d-3p (MIRT545204)
- hsa-mir-20b-5p (MIRT545205)
- hsa-mir-20a-5p (MIRT545206)
- hsa-mir-17-5p (MIRT545207)
- hsa-mir-106b-5p (MIRT545208)
- hsa-mir-106a-5p (MIRT545209)
- hsa-mir-548ah-5p (MIRT545210)
- hsa-mir-3609 (MIRT545211)
- hsa-mir-559 (MIRT545212)
- hsa-mir-548y (MIRT545213)
- hsa-mir-548w (MIRT545214)
- hsa-mir-548o-5p (MIRT545215)
- hsa-mir-548j-5p (MIRT545216)
- hsa-mir-548i (MIRT545217)
- hsa-mir-548h-5p (MIRT545218)
- hsa-mir-548d-5p (MIRT545219)
- hsa-mir-548c-5p (MIRT545220)
- hsa-mir-548bb-5p (MIRT545221)
- hsa-mir-548b-5p (MIRT545222)
- hsa-mir-548ay-5p (MIRT545223)
- hsa-mir-548au-5p (MIRT545224)
- hsa-mir-548as-5p (MIRT545225)
- hsa-mir-548ar-5p (MIRT545226)
- hsa-mir-548aq-5p (MIRT545227)
- hsa-mir-548ap-5p (MIRT545228)
- hsa-mir-548am-5p (MIRT545229)
- hsa-mir-548ak (MIRT545230)
- hsa-mir-548ae-5p (MIRT545231)
- hsa-mir-548ad-5p (MIRT545232)
- hsa-mir-548ab (MIRT545233)
- hsa-mir-548a-5p (MIRT545234)
- hsa-mir-8067 (MIRT551741)
- hsa-mir-6508-5p (MIRT551742)
- hsa-mir-670-3p (MIRT648725)
- hsa-mir-6894-3p (MIRT648726)
- hsa-mir-6794-3p (MIRT648727)
- hsa-mir-7162-5p (MIRT648728)
- hsa-mir-516b-3p (MIRT648729)
- hsa-mir-516a-3p (MIRT648730)
- hsa-mir-2115-5p (MIRT648731)
- hsa-mir-4763-5p (MIRT648732)
- hsa-mir-627-3p (MIRT648733)
- hsa-mir-1306-3p (MIRT648734)
- hsa-mir-4639-3p (MIRT648735)
- hsa-mir-6780a-3p (MIRT724156)
- hsa-mir-6852-3p (MIRT724157)
- hsa-mir-3909 (MIRT724158)
- hsa-mir-1292-3p (MIRT724159)
- hsa-mir-6850-3p (MIRT724160)
miRNA Products
- Search ViGene Biosciences for HIST1H2BD
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST1H2BD
- Browse OriGene Inhibitory RNA Products For HIST1H2BD
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BD gene
Clone Products
- Sino Biological Human cDNA Clone for HIST1H2BD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST1H2BD
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H2BD gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2BD gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BD gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BD Gene
Localization for HIST1H2BD Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BD Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005634 | nucleus | IDA | 16319397 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HIST1H2BD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST1H2BD Gene
68 Reactome pathways for HIST1H2BD Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H2BD Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2BD Gene
Interacting Proteins for HIST1H2BD Gene
Selected Interacting proteins:
ENSP00000289316
P58876-H2B1D_HUMAN
for HIST1H2BD Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | IBA | -- |
| GO:0016567 | protein ubiquitination | TAS | -- |
No data available for SIGNOR curated interactions for HIST1H2BD Gene
Transcripts for HIST1H2BD Gene
mRNA/cDNA for HIST1H2BD Gene
- (3) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (76) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H2BD Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2BD
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BD
- GenScript: Design CRISPR guide RNA sequences for HIST1H2BD
miRNA Products
- Search ViGene Biosciences for HIST1H2BD
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST1H2BD
- Browse OriGene Inhibitory RNA Products For HIST1H2BD
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BD gene
Clone Products
- Sino Biological Human cDNA Clone for HIST1H2BD
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H2BD Gene
mRNA differential expression in normal tissues according to GTEx for HIST1H2BD Gene
This gene is overexpressed in Whole Blood (x4.3).
This gene is overexpressed in Saliva (57.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H2BD Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HIST1H2BD Gene:
HIST1H2BDSOURCE GeneReport for Unigene cluster for HIST1H2BD Gene:
Hs.591797Evidence on tissue expression from TISSUES for HIST1H2BD Gene
- Blood(4.3)
- Spleen(2.7)
- Intestine(2.3)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs for HIST1H2BD
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2BD Gene
Orthologs for HIST1H2BD Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HIST1H2BI 35 |
|
OneToOne | |
| HIST1H2BD 34 |
|
||||
| mouse (Mus musculus) |
Mammalia | Hist1h2bm 35 |
|
OneToOne | |
| Hist3h2ba 34 16 |
|
||||
| chimpanzee (Pan troglodytes) |
Mammalia | HIST1H2BD 35 |
|
OneToOne | |
| LOC462491 34 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | LOC611089 34 |
|
||
| -- 35 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Hist3h2ba 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | wufe11b02 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5545 34 |
|
- Species where no ortholog for HIST1H2BD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST1H2BD Gene
Paralogs for HIST1H2BD Gene
(23) SIMAP similar genes for HIST1H2BD Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HIST1H2BD Gene
Variants for HIST1H2BD Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000015128 | -- | 26,157,852(+) | AAAAA(A/G)GTCGG | upstream-variant-2KB | |
| rs1000066168 | -- | 26,158,087(+) | AATAC(A/C/T)GCATC | upstream-variant-2KB, utr-variant-5-prime | |
| rs1000279080 | -- | 26,163,531(+) | TTGAC(C/T)GTAGC | intron-variant | |
| rs1000406825 | -- | 26,164,790(+) | GGCTC(-/T)TGGTG | intron-variant | |
| rs1000412746 | -- | 26,169,308(+) | TATGG(C/T)GGTCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv375n21 | CNV | loss | 19592680 |
| dgv5926n100 | CNV | gain | 25217958 |
| esv3608394 | CNV | loss | 21293372 |
| esv3608395 | CNV | gain | 21293372 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv970083 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
30.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.66;
31.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H2BD Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H2BD
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BD Gene
Disorders for HIST1H2BD Gene
Relevant External Links for HIST1H2BD
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H2BD
No disorders were found for HIST1H2BD Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BD Gene
Publications for HIST1H2BD Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PMID: 1916825) Albig W. … Doenecke D. (Genomics 1991) 2 3 4 64
- Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PMID: 16319397) Bonenfant D. … van Oostrum J. (Mol. Cell. Proteomics 2006) 3 4 64
- Gene-specific characterization of human histone H2B by electron capture dissociation. (PMID: 16457587) Siuti N. … Pesavento J.J. (J. Proteome Res. 2006) 3 4 64
- Quantitative proteomic analysis of post-translational modifications of human histones. (PMID: 16627869) Beck H.C. … Jensen O.N. (Mol. Cell. Proteomics 2006) 3 4 64
Products for HIST1H2BD Gene
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- GenScript: Next-day shipping cDNA ORF clone for HIST1H2BD in any vector
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- antibodies-online Antibodies for HIST1H2BD: See all 18
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- GeneTex HIST1H2BD antibody for HIST1H2BD
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- ViGene Biosciences adenoviral particle packaged cDNA for HIST1H2BD gene
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- ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BD gene
- Search ViGene Biosciences for HIST1H2BD
- Search Santa Cruz Biotechnology (SCBT) for HIST1H2BD Antibodies
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- Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BD
- Horizon Cell Lines for HIST1H2BD
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIST1H2BD
- VectorBuilder custom plasmid, inducible vectors for HIST1H2BD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIST1H2BD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H2BD Gene
- (1) GeneCards
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- (40) Pseudogene
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- (68) Abcam
- (69) Novus
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- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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- (100) COMPARTMENTS
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- (155) Gene ORGANizer