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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2BC Gene

protein-coding   GIFtS: 54
GCID: GC06M026115

Histone Cluster 1, H2bc

(Previous names: H2B histone family, member L, histone 1, H2bc)
(Previous symbol: H2BFL)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H2bc1 2     H2B/g3
H2BFL1 2 3 5     H2B/h3
H2B Histone Family, Member L1 2     H2B/k3
Histone 1, H2bc1 2     H2BFA3
Histone H2B.1 A2 3     H2BFG3
Histone H2B.L2 3     H2BFH3
H2B/l2 3     H2BFK3
H2B.12     Histone H2B.A3
dJ221C16.32     Histone H2B.G3
Histone H2B Type 1-C/E/F/G/I2     Histone H2B.H3
H2B/a3     Histone H2B.K3

External Ids:    HGNC: 47571   Entrez Gene: 83472   Ensembl: ENSG000001805967   OMIM: 6028475   UniProtKB: P628073   

Export aliases for HIST1H2BC gene to outside databases

Previous GC identifers: GC06M026172 GC06M026222 GC06M026066


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2BC Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2BC Gene: 
HIST1H2BC (histone cluster 1, H2bc) is a protein-coding gene. Diseases associated with HIST1H2BC include hemochromatosis, and systemic lupus erythematosus, and among its related super-pathways are Signal transduction Activin A signaling regulation and Systemic lupus erythematosus. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot: H2B1C_HUMAN, P62807
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling
Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST1H2BC (Histone H2B type 1-C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2BC gene promoter:
         NRSF form 1   GCNF   NRSF form 2   CBF-A   CBF-B   GCNF-1   CP1A   NF-Y   GCNF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2BC promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2BC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2BC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BC gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026115:  view genomic region     (about GC identifiers)

Start:
26,115,101 bp from pter      End:
26,124,154 bp from pter
Size:
9,054 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H2B1C_HUMAN, P62807 (See protein sequence)
Recommended Name: Histone H2B type 1-C/E/F/G/I  
Size: 126 amino acids; 13906 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Secondary accessions: P02278 Q3B872 Q4VB69 Q93078 Q93080

Explore the universe of human proteins at neXtProt for HIST1H2BC: NX_P62807

Explore proteomics data for HIST1H2BC at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II
  • UniProtKB: Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination
  • UniProtKB: GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P62807

  • HIST1H2BC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H2BC Protein Expression
    REFSEQ proteins: NP_003517.2  
    ENSEMBL proteins: 
     ENSP00000321744   ENSP00000380180  
    Reactome Protein details: P62807
    Human Recombinant Protein Products for HIST1H2BC: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals HIST1H2BC Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H2BC 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS422550
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    HIST1H2BC for ontologies           About GeneDecksing



    HIST1H2BC Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H2BC
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    Assay Products for HIST1H2BC: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P62807

    ProtoNet protein and cluster: P62807

    UniProtKB/Swiss-Prot: H2B1C_HUMAN, P62807
    Similarity: Belongs to the histone H2B family


    HIST1H2BC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B1C_HUMAN, P62807
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling
    Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial
    barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS422550
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    HIST1H2BC for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H2BC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST1H2BC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H2BC 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H2BC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    3Viral carcinogenesis
    Viral carcinogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2BC
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2BC
        Signal transduction Activin A signaling regulation

    5/11        Reactome Pathways for HIST1H2BC (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST1H2BC):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H2BC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2BC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/209 Interacting proteins for HIST1H2BC (P628072, 3 ENSP000003217444) via UniProtKB, MINT, STRING, and/or I2D (see all 209)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS422550
    GO:0042742defense response to bacterium IEA--

    HIST1H2BC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2BC (H2B1C)

    Search CenterWatch for drugs/clinical trials and news about HIST1H2BC / H2B1C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H2BC gene: 
    NM_003526.2  

    Unigene Clusters for HIST1H2BC:

    Histone cluster 1, H2bc
    Hs.658713  [show with all ESTs], Hs.726509  [show with all ESTs]
    Unigene Representative Sequences: BU902519, BF210626
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314332(uc003ngk.4) ENST00000396984(uc003ngl.3)
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BC

    Additional mRNA sequence: 

    AK312096.1 BC105595.1 

    3 DOTS entries:

    DT.311301  DT.100775625  DT.95159743 

    24/74 AceView cDNA sequences (see all 74):

    BU902519 BM841282 BQ268201 AI027954 BE645918 BQ186808 AL601008 AA344186 
    CK299919 BC009612 BQ923959 H70775 AV761592 CB146019 BX367100 CK906004 
    BQ267932 AA084581 BQ933803 BV173231 AA722183 CB529450 R08388 BQ447855 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2BC expression in normal human tissues (normalized intensities)      HIST1H2BC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTCTTTCG
    HIST1H2BC Expression
    About this image


    HIST1H2BC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/23 selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Podocytes Podocyte Layer
             Metanephros
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             BONE MARROW   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi

    See HIST1H2BC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2BC

    SOURCE GeneReport for Unigene clusters: Hs.658713 Hs.726509
        SABiosciences Custom PCR Arrays for HIST1H2BC
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for HIST1H2BC gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2bc5
    Hist1h2be1
    histone cluster 1, H2bc5
    histone cluster 1, H2be1
    92.86(n)1
    100(a)1
      13 (9.87 cM)5
    3191791  NM_001177653.11  NP_001171124.11 
     236841995 


    ENSEMBL Gene Tree for HIST1H2BC (if available)
    TreeFam Gene Tree for HIST1H2BC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2BC gene
    HIST1H2BE1 2  HIST1H2BI1 2  HIST1H2BF1 2  HIST1H2BG1 2  HIST2H2BE1 2  HIST1H2BN2  HIST1H2BD2  HIST1H2BB2  
    HIST1H2BM2  HIST3H2BB2  HIST1H2BK2  HIST2H2BF2  HIST1H2BH2  HIST1H2BL2  HIST1H2BO2  HIST1H2BJ2  
    18/23 SIMAP similar genes for HIST1H2BC using alignment to 2 protein entries:     H2B1C_HUMAN (see all proteins) (see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BH    HIST1H2BI    HIST1H2BJ    HIST1H2BK
    HIST1H2BM    HIST1H2BN    HIST1H2BO    HIST2H2BE    HIST2H2BF    HIST3H2BB
    HIST1H2BE    HIST1H2BF    HIST1H2BG    H2BFS    HIST1H2BL    HIST2H2BC

    HIST1H2BC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/18 SNPs in HIST1H2BC are shown (see all 18)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0558874
    ----see VAR_0558872 G S mis40--------
    rs1428888441,2
    C--26125436(+) AGAACA/GGTGCC 1 -- us2k10--------
    rs1809170471,2
    --26125472(+) TAAGAA/GGCTCA 1 -- us2k10--------
    rs1870605921,2
    --26125622(+) CGACAA/CTAACC 1 -- us2k10--------
    rs125242211,2
    H--26125640(+) catggG/Tgaaac 1 -- us2k10--------
    rs1460808551,2
    --26125704(+) ACATAC/TCTTGT 1 -- us2k10--------
    rs1166826251,2
    C--26125708(+) ACCTTG/TTAATC 1 -- us2k10--------
    rs1988181,2
    C,F,A--26125711(+) ttgtaA/Ctccca 1 -- us2k18Minor allele frequency- C:0.19NA WA EA 368
    rs69318631,2
    C,F--26125824(+) ACACGG/ATCCCC 1 -- us2k13Minor allele frequency- A:0.16WA NA EA 358
    rs69315421,2
    C,F--26125826(+) ACGGTC/ACCCCA 1 -- us2k13Minor allele frequency- A:0.16WA NA EA 358

    HapMap Linkage Disequilibrium report for HIST1H2BC (26115101 - 26124154 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H2BC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428137CNV Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602847    OMIM disorders: --

    3 diseases for HIST1H2BC:    About MalaCards
    hemochromatosis    systemic lupus erythematosus    lupus erythematosus


    HIST1H2BC for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIST1H2BC

    Export disorders for HIST1H2BC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2BC gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with HIST1H2BC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)1, 4 Johnson A.D....Witteman J.C. (2009)
    4. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    5. Human spleen histone H2B. Isolation and amino acid sequence. (PubMed id 422550)1, 2 Ohe Y.... Iwai K. (1979)
    6. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    7. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    10. GlcNAcylation of histone H2B facilitates its monoubiquitination. (PubMed id 22121020)2 Fujiki R.... Kato S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8347 HGNC: 4757 AceView: HIST1H2BC Ensembl:ENSG00000180596 euGenes: HUgn8347
    ECgene: HIST1H2BC Kegg: 8347 H-InvDB: HIST1H2BC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2BC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H2BC gene:
    Search GeneIP for patents involving HIST1H2BC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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