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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2BC Gene

protein-coding   GIFtS: 50
GCID: GC06M026115

histone cluster 1, H2bc

(Previous names: H2B histone family, member L, histone 1, H2bc )
(Previous symbol: H2BFL)
 Explore 4 diseases affiliated with
HIST1H2BC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H2BC    

Aliases
for HIST1H2BC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H2bc1 2     H2B/G1
H2BFL1 2 3 5     H2B/H1
H2B/L1     H2B/K1
H2B.11 2     H2BFA3
H2B Histone Family, Member L1 2     H2BFG3
Histone 1, H2bc1 2     H2BFH3
Histone H2B.1 A2 3     H2BFK3
Histone H2B.L2 3     Histone H2B.A3
DJ221C16.31     Histone H2B.G3
Histone H2B Type 1-C/E/F/G/I2     Histone H2B.H3
H2B/A1     Histone H2B.K3

External Ids:    HGNC: 47571   Entrez Gene: 83472   Ensembl: ENSG000001805967   OMIM: 6028475   UniProtKB: P628073   

Export aliases for HIST1H2BC gene to outside databases

Previous GC identifers: GC06M026172 GC06M026222 GC06M026066


Summaries
for HIST1H2BC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H2BC:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2B1C_HUMAN, P62807
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling
Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of
the colonic epithelium, and to the bactericidal activity of amniotic fluid

Gene Wiki entry for HIST1H2BC (Histone H2B type 1-C)


Genomic Views
for HIST1H2BC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2BC gene promoter:
         NRSF form 1   GCNF   NRSF form 2   CBF-A   CBF-B   GCNF-1   CP1A   NF-Y   GCNF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H2BC promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2BC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2BC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BC gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026115:  view genomic region     (about GC identifiers)

Start:
 26,115,129 bp from pter      End:
 26,124,154 bp from pter
Size:
 9,026 bases      Orientation:
 minus strand

Proteins
for HIST1H2BC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2B1C_HUMAN, P62807 (See protein sequence)
Recommended Name: Histone H2B type 1-C/E/F/G/I  
Size: 126 amino acids; 13906 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Secondary accessions: P02278 Q3B872 Q4VB69 Q93078 Q93080

Explore the universe of human proteins at neXtProt for HIST1H2BC: NX_P62807

Post-translational modifications:

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79'
    • (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly,
    monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional
    activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively
    with the FACT dimer to stimulate elongation by RNA polymerase II1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    • Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation.
    Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic
    hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose,
    • and associates with transcribed genes1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62807

    • HIST1H2BC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003517.2  
    ENSEMBL proteins: 
     ENSP00000380180   ENSP00000321744  
    Reactome Protein details: P62807
    Human Recombinant Protein Products: 
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    Novus Biologicals HIST1H2BC Protein
    Novus Biologicals HIST1H2BC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H2BC

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS422550
    GO:0005634nucleus IEA--


    HIST1H2BC for ontologies           About GeneDecksing



    HIST1H2BC Antibody Products: 
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    Uscn Antibodies for HIST1H2BC
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    Uscn ELISAs and CLIAs for HIST1H2BC

    Protein Domains /
    Families
    for HIST1H2BC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H2BC for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P62807

    ProtoNet protein and cluster: P62807

    UniProtKB/Swiss-Prot: H2B1C_HUMAN, P62807
    Similarity: Belongs to the histone H2B family


    Function
    for HIST1H2BC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2B1C_HUMAN, P62807
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling
    Function: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of
    the colonic epithelium, and to the bactericidal activity of amniotic fluid

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H2BC:
    hsa-miR-1276
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    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HIST1H2BC

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BC 

    Cell Line
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    Search LifeMap BioReagents cell lines for HIST1H2BC

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS422550
    GO:0046982protein heterodimerization activity IEA--


    HIST1H2BC for ontologies           About GeneDecksing



    Pathways & Interactions
    for HIST1H2BC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    2Systemic lupus erythematosus
    		Systemic lupus erythematosus1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2BC
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2BC
        Signal transduction Activin A signaling regulation

    5/17        Reactome Pathways for HIST1H2BC (see all 17)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Disease


    1         Kegg Pathway  (Kegg details for HIST1H2BC):
        Systemic lupus erythematosus


    HIST1H2BC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2BC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/200 Interacting proteins for HIST1H2BC (P628072, 3 ENSP000003217444) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=4 
    HIST1H4BP628053I2D: score=4 
    HIST1H4CP628053I2D: score=4 
    HIST1H4DP628053I2D: score=4 
    HIST1H4EP628053I2D: score=4 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS422550
    GO:0042742defense response to bacterium IEA--


    HIST1H2BC for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H2BC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2BC
    Search CenterWatch for drugs/clinical trials and news about HIST1H2BC / H2B1C 

    Transcripts
    for HIST1H2BC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H2BC gene: 
    NM_003526.2  

    Unigene Clusters for HIST1H2BC:

    Histone cluster 1, H2bc
    Hs.658713  [show with all ESTs], Hs.726509  [show with all ESTs]
    Unigene Representative Sequences: BU902519, BF210626
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396984(uc003ngl.3) ENST00000314332(uc003ngk.4)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H2BC
    1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H2BC:
    hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2BC (see all 4)
    OriGene shRNA RFP: HIST1H2BC
    OriGene siRNA: HIST1H2BC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2BC
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BC

    Additional cDNA sequence: 

    AK312096.1 BC105595.1 

    3 DOTS entries:

    DT.311301  DT.100775625  DT.95159743 

    24/74 AceView cDNA sequences (see all 74):

    AI027954 BU902519 AL601008 AV761592 BE645918 BC009612 BQ186808 CK299919 
    BM841282 AA344186 BQ923959 H70775 BQ268201 BE263766 BQ267932 BG616971 
    R08388 BI597616 CK906004 BV173231 AI263307 CB146019 AA722183 BI604131 

    GeneLoc Exon Structure


    Expression
    for HIST1H2BC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2BC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTCTTTCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HIST1H2BC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2BC

    SOURCE GeneReport for Unigene clusters: Hs.658713 Hs.726509
        SABiosciences Custom PCR Arrays for HIST1H2BC
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    In Situ
    Assay Products:     
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    Orthologs
    for HIST1H2BC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H2BC gene from 3/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H2B1_CHICK6
    H2B1_CHICK6
    (see all 8)    		 Histone H2B 1/2/3/4/6
    (see all 8)    		 96(a)
    96(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 1(50028609-50028989)
    1(49976548-49976928)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 8)    		 --
    		 94(a)
    94(a)
    (see all 8)    		 many ↔ many
    many ↔ many
    (see all 8)    		 GL343466.1(297869-298249)
    GL343466.1(314932-315312)
    zebrafish
    (Danio rerio)    		 Actinopterygii hist2h2l6
    zgc:1717596
    (see all 33)    		 zgc:171759
    (see all 33)    		 94(a)
    93(a)
    (see all 33)    		 1 ↔ many
    possible ortholog
    (see all 33)    		 10(30723402-30724224)
    25(36216949-36218167)


    ENSEMBL Gene Tree for HIST1H2BC (if available)
    TreeFam Gene Tree for HIST1H2BC (if available) 

    Paralogs
    for HIST1H2BC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2BC gene
    HIST1H2BE1 2  HIST1H2BI1 2  HIST1H2BF1 2  HIST1H2BG1 2  HIST2H2BE1 2  HIST3H2BB2  HIST1H2BK2  HIST1H2BD2  
    HIST2H2BF2  HIST1H2BH2  HIST1H2BL2  HIST1H2BO2  HIST1H2BJ2  HIST1H2BB2  
    18/22 SIMAP similar genes for HIST1H2BC using alignment to 2 protein entries:     H2B1C_HUMAN (see all proteins) (see all similar genes):
    HIST1H2BB    HIST1H2BD    HIST1H2BF    HIST1H2BH    HIST1H2BJ    HIST1H2BK
    HIST1H2BM    HIST1H2BN    HIST1H2BO    HIST2H2BE    HIST2H2BF    HIST3H2BB
    HIST1H2BE    HIST1H2BG    HIST1H2BI    H2BFS    HIST1H2BL    HIST2H2BC

    HIST1H2BC for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H2BC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/12 NCBI SNPs in HIST1H2BC are shown (see all 12)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1428888441,2
    		--26125436(+) AGAACA/GGTGCC 1 -- us2k10--------
    rs1809170471,2
    		--26125472(+) TAAGAA/GGCTCA 1 -- us2k10--------
    rs1870605921,2
    		--26125622(+) CGACAA/CTAACC 1 -- us2k10--------
    rs125242211,2
    		H--26125640(+) catggG/Tgaaac 1 -- us2k10--------
    rs1460808551,2
    		--26125704(+) ACATAC/TCTTGT 1 -- us2k10--------
    rs1166826251,2
    		C,--26125708(+) ACCTTG/TTAATC 1 -- us2k10--------
    rs1988181,2
    		C,F,A,--26125711(+) TTGTAA/CTCCCA 1 -- us2k18Minor allele frequency- C:0.19NA WA EA 368
    rs69318631,2
    		C,F,--26125824(+) ACACGG/ATCCCC 1 -- us2k13Minor allele frequency- A:0.16WA NA EA 358
    rs69315421,2
    		C,F,--26125826(+) ACGGTC/ACCCCA 1 -- us2k13Minor allele frequency- A:0.16WA NA EA 358
    rs1493375561,2
    		--26125938(+) TCTGTA/GAATCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2BC (26115129 - 26124154 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H2BC: --

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    Disorders / Diseases
    for HIST1H2BC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H2BC for disorders           About GeneDecksing

    OMIM gene information: 602847    OMIM disorders: --

    4 diseases for HIST1H2BC:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    hemochromatosis    immunodeficiency


    Export disorders for HIST1H2BC gene to outside databases

    Publications
    for HIST1H2BC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2BC gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with HIST1H2BC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    4. Human spleen histone H2B. Isolation and amino acid sequence. (PubMed id 422550)1, 2 Ohe Y.... Iwai K. (1979)
    5. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. GlcNAcylation of histone H2B facilitates its monoubiquitination. (PubMed id 22121020)2 Fujiki R.... Kato S. (2011)
    8. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
    9. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
    10. The RING finger protein MSL2 in the MOF complex is an E3 ubiquitin ligase for H2B K34 and is involved in crosstalk with H3 K4 and K7 9 methylation. (PubMed id 21726816)2 Wu L....Dou Y. (2011)

    External Searches for HIST1H2BC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing HIST1H2BC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8347 HGNC: 4757 AceView: HIST1H2BC Ensembl:ENSG00000180596 euGenes: HUgn8347
    ECgene: HIST1H2BC Kegg: 8347 H-InvDB: HIST1H2BC

    Other Databases showing HIST1H2BC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H2BC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2BC Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H2BC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H2BC gene:
    Search GeneIP for patents involving HIST1H2BC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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