Aliases for HIST1H2BB Gene
Aliases for HIST1H2BB Gene
External Ids for HIST1H2BB Gene
- HGNC: 4751
- Entrez Gene: 3018
- Ensembl: ENSG00000276410
- OMIM: 602803
- UniProtKB: P33778
Previous HGNC Symbols for HIST1H2BB Gene
- H2BFF
Previous GeneCards Identifiers for HIST1H2BB Gene
- GC06M026100
- GC06M026151
- GC06M025986
Summaries for HIST1H2BB Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H2BB Gene
HIST1H2BB (Histone Cluster 1 H2B Family Member B) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.
UniProtKB/Swiss-Prot for HIST1H2BB Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BB Gene
Genomics for HIST1H2BB Gene
Regulatory Element Products
Genomic Location for HIST1H2BB Gene
- Chromosome:
- 6
- Start:
- 26,043,227 bp from pter
- End:
- 26,043,657 bp from pter
- Size:
- 431 bases
- Orientation:
- Minus strand
Genomic View for HIST1H2BB Gene
Genes around HIST1H2BB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H2BB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H2BB Gene
Proteins for HIST1H2BB Gene
-
Protein details for HIST1H2BB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P33778-H2B1B_HUMAN
- Recommended name:
- Histone H2B type 1-B
- Protein Accession:
- P33778
- Q4KN36
Protein attributes for HIST1H2BB Gene
- Size:
- 126 amino acids
- Molecular mass:
- 13950 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST1H2BB Gene
Post-translational modifications for HIST1H2BB Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
- Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
- Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
- Ubiquitination at posLast=121121
- Glycosylation at isoforms=113
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H2BB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for HIST1H2BB (H2B)
-
Custom Antibody ServicesOriGene Antibodies for HIST1H2BB
- Novus Biologicals Antibodies for HIST1H2BB
- Invitrogen Antibodies for HIST1H2BB
- antibodies-online Antibodies for HIST1H2BB: See all 4
- GeneTex HIST1H2BB antibody for HIST1H2BB
Protein Products
-
OriGene Purified Proteins for HIST1H2BB
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- Novus Biologicals lysates for HIST1H2BB
- antibodies-online Proteins for HIST1H2BB: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HIST1H2BB
Assay Products
No data available for DME Specific Peptides for HIST1H2BB Gene
Domains & Families for HIST1H2BB Gene
Gene Families for HIST1H2BB Gene
- HGNC:
Protein Domains for HIST1H2BB Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H2BB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P33778- Family:
-
- Belongs to the histone H2B family.
Function for HIST1H2BB Gene
Molecular function for HIST1H2BB Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | NAS | 9439656 |
| GO:0005515 | protein binding | IPI | 22720776 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H2BB Gene
- GenomeRNAi human phenotypes for HIST1H2BB:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2BB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BB gene
- Search ViGene Biosciences for HIST1H2BB
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2BB
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BB
- GenScript: Design CRISPR guide RNA sequences for HIST1H2BB
miRNA for HIST1H2BB Gene
- miRTarBase miRNAs that target HIST1H2BB
-
- hsa-mir-34a-5p (MIRT025273)
- hsa-mir-652-3p (MIRT039494)
- hsa-mir-196a-5p (MIRT048188)
- hsa-mir-760 (MIRT360243)
- hsa-mir-6822-3p (MIRT360247)
- hsa-mir-5693 (MIRT511736)
- hsa-mir-6839-3p (MIRT511737)
- hsa-mir-4507 (MIRT511738)
- hsa-mir-3940-5p (MIRT511739)
- hsa-mir-8057 (MIRT511740)
- hsa-mir-6079 (MIRT511741)
- hsa-mir-629-5p (MIRT511742)
- hsa-mir-4766-5p (MIRT511743)
- hsa-mir-146a-3p (MIRT511744)
- hsa-mir-1276 (MIRT511745)
- hsa-mir-6802-5p (MIRT523237)
- hsa-mir-6865-5p (MIRT523238)
- hsa-mir-6815-5p (MIRT523239)
miRNA Products
- Search ViGene Biosciences for HIST1H2BB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST1H2BB
- Browse OriGene Inhibitory RNA Products For HIST1H2BB
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BB gene
Clone Products
-
OriGene ORF clones in human for HIST1H2BB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
-
Horizon Cell Lines for HIST1H2BB
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H2BB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2BB gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BB Gene
Localization for HIST1H2BB Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BB Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | nuclear chromosome, telomeric region | IDA | 19135898 |
| GO:0000786 | nucleosome | NAS | 9439656 |
| GO:0005634 | nucleus | IEA,IDA | 16319397 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HIST1H2BB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Cellular Senescence | ||
| 4 | Chromosome Maintenance | ||
| 5 | Cell Cycle, Mitotic |
.83
|
.60
|
Pathways by source for HIST1H2BB Gene
2 Cell Signaling Technology pathways for HIST1H2BB Gene
68 Reactome pathways for HIST1H2BB Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
3 KEGG pathways for HIST1H2BB Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2BB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | NAS | 9439656 |
| GO:0016567 | protein ubiquitination | TAS | -- |
Transcripts for HIST1H2BB Gene
mRNA/cDNA for HIST1H2BB Gene
- (1) REFSEQ mRNAs :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2BB
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2BB
- GenScript: Design CRISPR guide RNA sequences for HIST1H2BB
miRNA Products
- Search ViGene Biosciences for HIST1H2BB
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST1H2BB
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-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H2BB gene
Clone Products
-
OriGene ORF clones in human for HIST1H2BB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H2BB
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIST1H2BB
Flow Cytometry Products
Expression for HIST1H2BB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Choroid Plexus Progenitor Cells Choroid Plexus
mRNA differential expression in normal tissues according to GTEx for HIST1H2BB Gene
This gene is overexpressed in Testis (x18.6).
This gene is overexpressed in Monocytes (13.5), Blymphocyte (12.4), Neutrophil (12.3), Tlymphocyte (8.1), and Saliva (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIST1H2BB Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H2BB Gene:
HIST1H2BBSOURCE GeneReport for Unigene cluster for HIST1H2BB Gene:
Hs.553494Primer Products
-
OriGene qPCR primer pairs for HIST1H2BB
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2BB Gene
Orthologs for HIST1H2BB Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| mouse (Mus musculus) |
Mammalia | Hist1h2bb 34 16 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC100855574 34 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | HIST1H2BB 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC102549061 34 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC614206 34 |
|
- Species where no ortholog for HIST1H2BB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIST1H2BB Gene
Paralogs for HIST1H2BB Gene
(23) SIMAP similar genes for HIST1H2BB Gene using alignment to 1 proteins:
Variants for HIST1H2BB Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000064690 | -- | 26,044,480(+) | GATTG(C/G/T)TTTGT | upstream-variant-2KB | |
| rs1001071216 | -- | 26,045,591(+) | CCGAG(C/T)TGCTG | upstream-variant-2KB, reference, synonymous-codon | |
| rs1002040428 | -- | 26,044,760(+) | CACCG(C/T)CCCCC | upstream-variant-2KB | |
| rs1002091133 | -- | 26,045,001(+) | GACAT(A/G)AGTCT | upstream-variant-2KB | |
| rs1003497669 | -- | 26,043,198(+) | AGAAA(C/T)TGTGG | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| esv3608392 | CNV | gain | 21293372 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv1026692 | CNV | loss | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv509122 | CNV | insertion | 20534489 |
| nsv970081 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.52;
11.34% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H2BB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H2BB
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BB Gene
Disorders for HIST1H2BB Gene
Relevant External Links for HIST1H2BB
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H2BB
No disorders were found for HIST1H2BB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BB Gene
Publications for HIST1H2BB Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R. … Reinberg D. (Cell 2006) 3 4 64
- Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4 64
- Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PMID: 16307923) Zhu B. … Reinberg D. (Mol. Cell 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for HIST1H2BB Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for HIST1H2BB gene
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H2BB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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