Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST1H2BB Gene

Aliases for HIST1H2BB Gene

  • Histone Cluster 1, H2bb 2 3 5
  • H2B Histone Family, Member F 2 3
  • Histone 1, H2bb 2 3
  • Histone H2B.1 3 4
  • Histone H2B.F 3 4
  • H2BFF 3 4
  • H2B/F 3 4
  • H2B.1 3

External Ids for HIST1H2BB Gene

Previous HGNC Symbols for HIST1H2BB Gene

  • H2BFF

Previous GeneCards Identifiers for HIST1H2BB Gene

  • GC06M026100
  • GC06M026151
  • GC06M025986

Summaries for HIST1H2BB Gene

Entrez Gene Summary for HIST1H2BB Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BB Gene

HIST1H2BB (Histone Cluster 1, H2bb) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2BH.

UniProtKB/Swiss-Prot for HIST1H2BB Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2BB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BB Gene

Genomics for HIST1H2BB Gene

Regulatory Elements for HIST1H2BB Gene

Genomic Location for HIST1H2BB Gene

Chromosome:
6
Start:
26,043,227 bp from pter
End:
26,123,904 bp from pter
Size:
80,678 bases
Orientation:
Minus strand

Genomic View for HIST1H2BB Gene

Genes around HIST1H2BB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2BB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2BB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BB Gene

Proteins for HIST1H2BB Gene

  • Protein details for HIST1H2BB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33778-H2B1B_HUMAN
    Recommended name:
    Histone H2B type 1-B
    Protein Accession:
    P33778
    Secondary Accessions:
    • Q4KN36

    Protein attributes for HIST1H2BB Gene

    Size:
    126 amino acids
    Molecular mass:
    13950 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2BB Gene

neXtProt entry for HIST1H2BB Gene

Proteomics data for HIST1H2BB Gene at MOPED

Post-translational modifications for HIST1H2BB Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HIST1H2BB (H2B)

No data available for DME Specific Peptides for HIST1H2BB Gene

Domains & Families for HIST1H2BB Gene

Gene Families for HIST1H2BB Gene

Protein Domains for HIST1H2BB Gene

Suggested Antigen Peptide Sequences for HIST1H2BB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P33778

UniProtKB/Swiss-Prot:

H2B1B_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BB: view

Function for HIST1H2BB Gene

Molecular function for HIST1H2BB Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
genes like me logo Genes that share phenotypes with HIST1H2BB: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BB Gene

Localization for HIST1H2BB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BB Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2BB Gene COMPARTMENTS Subcellular localization image for HIST1H2BB gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2BB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HIST1H2BB: view

Pathways & Interactions for HIST1H2BB Gene

SuperPathways for HIST1H2BB Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Packaging Of Telomere Ends
genes like me logo Genes that share pathways with HIST1H2BB: view

Pathways by source for HIST1H2BB Gene

Interacting Proteins for HIST1H2BB Gene

SIGNOR curated interactions for HIST1H2BB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HIST1H2BB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019731 antibacterial humoral response IDA --
GO:0050830 defense response to Gram-positive bacterium IDA --
genes like me logo Genes that share ontologies with HIST1H2BB: view

Drugs & Compounds for HIST1H2BB Gene

No Compound Related Data Available

Transcripts for HIST1H2BB Gene

mRNA/cDNA for HIST1H2BB Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BB Gene

No ASD Table

Relevant External Links for HIST1H2BB Gene

GeneLoc Exon Structure for
HIST1H2BB
ECgene alternative splicing isoforms for
HIST1H2BB

Expression for HIST1H2BB Gene

mRNA expression in normal human tissues for HIST1H2BB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2BB Gene

This gene is overexpressed in Testis (x18.6).

Protein differential expression in normal tissues from HIPED for HIST1H2BB Gene

This gene is overexpressed in Monocytes (13.5), Blymphocyte (12.4), Neutrophil (12.3), Tlymphocyte (8.1), and Saliva (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIST1H2BB Gene



SOURCE GeneReport for Unigene cluster for HIST1H2BB Gene Hs.553494

genes like me logo Genes that share expression patterns with HIST1H2BB: view

Protein tissue co-expression partners for HIST1H2BB Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H2BB Gene

Orthologs for HIST1H2BB Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2BB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC614206 35
  • 84.39 (n)
  • 91.27 (a)
dog
(Canis familiaris)
Mammalia LOC100855574 35
  • 86.51 (n)
  • 98.41 (a)
mouse
(Mus musculus)
Mammalia Hist1h2bb 35
  • 88.62 (n)
  • 97.62 (a)
Hist1h2bb 16
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BB 35
  • 86.51 (n)
  • 94.44 (a)
rat
(Rattus norvegicus)
Mammalia LOC102549061 35
  • 86.24 (n)
  • 98.41 (a)
Species with no ortholog for HIST1H2BB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2BB Gene

ENSEMBL:
Gene Tree for HIST1H2BB (if available)
TreeFam:
Gene Tree for HIST1H2BB (if available)

Paralogs for HIST1H2BB Gene

genes like me logo Genes that share paralogs with HIST1H2BB: view

Variants for HIST1H2BB Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2051537 -- 26,043,025(-) cagga(A/G)atgga downstream-variant-500B
rs6899861 -- 26,042,856(+) gtgcc(A/G)tggcg downstream-variant-500B
rs6900216 -- 26,043,075(+) gatta(A/C)aggca downstream-variant-500B
rs6900371 -- 26,043,067(+) attgc(C/T)gggat downstream-variant-500B
rs6900390 -- 26,043,093(+) ccgcg(A/C)acggc downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BB Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914
nsv509122 CNV Insertion 20534489

Variation tolerance for HIST1H2BB Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2BB Gene

HapMap Linkage Disequilibrium report
HIST1H2BB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BB Gene

Disorders for HIST1H2BB Gene

Relevant External Links for HIST1H2BB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2BB

No disorders were found for HIST1H2BB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BB Gene

Publications for HIST1H2BB Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones. (PMID: 8227173) Kardalinou E. … Doenecke D. (J. Cell. Biochem. 1993) 2 3
  3. Luzp4 defines a new mRNA export pathway in cancer cells. (PMID: 25662211) Viphakone N. … Wilson S.A. (Nucleic Acids Res. 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX. (PMID: 24530302) Lacoste N. … Almouzni G. (Mol. Cell 2014) 3

Products for HIST1H2BB Gene

Sources for HIST1H2BB Gene

Back to Top

Content