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Aliases for HIST1H2BB Gene

Aliases for HIST1H2BB Gene

  • Histone Cluster 1 H2B Family Member B 2 3 5
  • H2B Histone Family, Member F 2 3
  • Histone Cluster 1, H2bb 2 3
  • Histone 1, H2bb 2 3
  • Histone H2B.1 3 4
  • Histone H2B.F 3 4
  • H2BFF 3 4
  • H2B/F 3 4
  • Histone H2B Type 1-B 3
  • H2B.1 3

External Ids for HIST1H2BB Gene

Previous HGNC Symbols for HIST1H2BB Gene

  • H2BFF

Previous GeneCards Identifiers for HIST1H2BB Gene

  • GC06M026100
  • GC06M026151
  • GC06M025986

Summaries for HIST1H2BB Gene

Entrez Gene Summary for HIST1H2BB Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2BB Gene

HIST1H2BB (Histone Cluster 1 H2B Family Member B) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST2H2BE.

UniProtKB/Swiss-Prot for HIST1H2BB Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2BB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2BB Gene

Genomics for HIST1H2BB Gene

Regulatory Elements for HIST1H2BB Gene


Promoters for HIST1H2BB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001213970 -743 3601 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5

Genomic Location for HIST1H2BB Gene

Chromosome:
6
Start:
26,043,227 bp from pter
End:
26,043,657 bp from pter
Size:
431 bases
Orientation:
Minus strand

Genomic View for HIST1H2BB Gene

Genes around HIST1H2BB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2BB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2BB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2BB Gene

Proteins for HIST1H2BB Gene

  • Protein details for HIST1H2BB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P33778-H2B1B_HUMAN
    Recommended name:
    Histone H2B type 1-B
    Protein Accession:
    P33778
    Secondary Accessions:
    • Q4KN36

    Protein attributes for HIST1H2BB Gene

    Size:
    126 amino acids
    Molecular mass:
    13950 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2BB Gene

neXtProt entry for HIST1H2BB Gene

Post-translational modifications for HIST1H2BB Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).
  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 Lys-4 (H3K4me) and Lys-79 (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 Lys-4 and Lys-79 methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination.
  • Ubiquitination at Lys 121
  • Glycosylation at Ser 113
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2BB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2BB Gene

Domains & Families for HIST1H2BB Gene

Gene Families for HIST1H2BB Gene

Protein Domains for HIST1H2BB Gene

Suggested Antigen Peptide Sequences for HIST1H2BB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P33778

UniProtKB/Swiss-Prot:

H2B1B_HUMAN :
  • Belongs to the histone H2B family.
Family:
  • Belongs to the histone H2B family.
genes like me logo Genes that share domains with HIST1H2BB: view

Function for HIST1H2BB Gene

Molecular function for HIST1H2BB Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for HIST1H2BB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 9439656
GO:0005515 protein binding IPI 22720776
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2BB: view
genes like me logo Genes that share phenotypes with HIST1H2BB: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2BB Gene

Localization for HIST1H2BB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2BB Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H2BB gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for HIST1H2BB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0000786 nucleosome NAS 9439656
GO:0000788 nuclear nucleosome IBA --
GO:0005634 nucleus IEA,IDA 16319397
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HIST1H2BB: view

Pathways & Interactions for HIST1H2BB Gene

SuperPathways for HIST1H2BB Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 DNA Double-Strand Break Repair
3 Cellular Senescence
4 Chromosome Maintenance
5 Cell Cycle, Mitotic
.60
genes like me logo Genes that share pathways with HIST1H2BB: view

Interacting Proteins for HIST1H2BB Gene

SIGNOR curated interactions for HIST1H2BB Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HIST1H2BB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly NAS 9439656
genes like me logo Genes that share ontologies with HIST1H2BB: view

Transcripts for HIST1H2BB Gene

mRNA/cDNA for HIST1H2BB Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2BB Gene

No ASD Table

Relevant External Links for HIST1H2BB Gene

GeneLoc Exon Structure for
HIST1H2BB
ECgene alternative splicing isoforms for
HIST1H2BB

Expression for HIST1H2BB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HIST1H2BB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2BB Gene

This gene is overexpressed in Testis (x18.6).

Protein differential expression in normal tissues from HIPED for HIST1H2BB Gene

This gene is overexpressed in Monocytes (13.5), Blymphocyte (12.4), Neutrophil (12.3), Tlymphocyte (8.1), and Saliva (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIST1H2BB Gene



Protein tissue co-expression partners for HIST1H2BB Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST1H2BB Gene:

HIST1H2BB

SOURCE GeneReport for Unigene cluster for HIST1H2BB Gene:

Hs.553494
genes like me logo Genes that share expression patterns with HIST1H2BB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H2BB Gene

Orthologs for HIST1H2BB Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2BB Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hist1h2bb 34 16
  • 88.62 (n)
dog
(Canis familiaris)
Mammalia LOC100855574 34
  • 86.51 (n)
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2BB 34
  • 86.51 (n)
rat
(Rattus norvegicus)
Mammalia LOC102549061 34
  • 86.24 (n)
cow
(Bos Taurus)
Mammalia LOC614206 34
  • 84.39 (n)
Species where no ortholog for HIST1H2BB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2BB Gene

ENSEMBL:
Gene Tree for HIST1H2BB (if available)
TreeFam:
Gene Tree for HIST1H2BB (if available)

Paralogs for HIST1H2BB Gene

Variants for HIST1H2BB Gene

Sequence variations from dbSNP and Humsavar for HIST1H2BB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111706643 -- 26,044,546(+) TTACT(A/G)CAACC upstream-variant-2KB
rs114139519 -- 26,044,499(+) AGTCT(A/G)GTTCT upstream-variant-2KB
rs11418356 -- 26,044,759(+) CACCG(-/C)CCCCC upstream-variant-2KB
rs114606120 -- 26,043,106(+) CGTCC(A/C)AGTTA downstream-variant-500B
rs116725397 -- 26,045,398(+) TGTGT(G/T)CTCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2BB Gene

Variant ID Type Subtype PubMed ID
dgv5926n100 CNV gain 25217958
esv3608392 CNV gain 21293372
nsv1023453 CNV gain 25217958
nsv1026692 CNV loss 25217958
nsv428137 CNV loss 18775914
nsv509122 CNV insertion 20534489
nsv970081 CNV duplication 23825009

Variation tolerance for HIST1H2BB Gene

Residual Variation Intolerance Score: 45.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2BB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H2BB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2BB Gene

Disorders for HIST1H2BB Gene

Relevant External Links for HIST1H2BB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2BB

No disorders were found for HIST1H2BB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2BB Gene

Publications for HIST1H2BB Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  2. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PMID: 16713563) Pavri R. … Reinberg D. (Cell 2006) 3 4 64
  3. Inhibition of core histones acetylation by carcinogenic nickel(II). (PMID: 16283522) Golebiowski F. … Kasprzak K.S. (Mol. Cell. Biochem. 2005) 3 4 64
  4. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PMID: 16307923) Zhu B. … Reinberg D. (Mol. Cell 2005) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for HIST1H2BB Gene

Sources for HIST1H2BB Gene

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