Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIST1H2BB Gene

protein-coding   GIFtS: 55
GCID: GC06M026043

Histone Cluster 1, H2bb

(Previous names: H2B histone family, member F, histone 1, H2bb)
(Previous symbol: H2BFF)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histone Cluster 1, H2bb1 2     Histone H2B.F2 3
H2BFF1 2 3 5     H2B/f2 3
H2B Histone Family, Member F1 2     H2B.12
Histone 1, H2bb1 2     Histone H2B Type 1-B2
Histone H2B.12 3     

External Ids:    HGNC: 47511   Entrez Gene: 30182   Ensembl: ENSG000001962267   OMIM: 6028035   UniProtKB: P337783   

Export aliases for HIST1H2BB gene to outside databases

Previous GC identifers: GC06M026100 GC06M026151 GC06M025986


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HIST1H2BB Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene
lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large
histone gene cluster on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2BB Gene:
HIST1H2BB (histone cluster 1, H2bb) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2BN.

UniProtKB/Swiss-Prot: H2B1B_HUMAN, P33778
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2BB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H2BB gene promoter:
         HOXA9   HOXA9B   Pax-5   Cdc5   E47   AREB6   FOXO4   Meis-1a   ZID   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2BB promoter sequence
   Search Chromatin IP Primers for HIST1H2BB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2BB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2BB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026043:  view genomic region     (about GC identifiers)

Start:
26,043,455 bp from pter      End:
26,043,885 bp from pter
Size:
431 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: H2B1B_HUMAN, P33778 (See protein sequence)
Recommended Name: Histone H2B type 1-B  
Size: 126 amino acids; 13950 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Secondary accessions: Q4KN36

Explore the universe of human proteins at neXtProt for HIST1H2BB: NX_P33778

Explore proteomics data for HIST1H2BB at MOPED

Post-translational modifications: 

  • Monoubiquitination at Lys-35 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-121 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as
    a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a
    large set of exons1
  • Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity).
    Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin
    condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation
    with somatic hypermutation and immunoglobulin class-switch recombination1
  • GlcNAcylation at Ser-113 promotes monoubiquitination of Lys-121. It fluctuates in response to extracellular
    glucose, and associates with transcribed genes (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys44, Lys47, Lys58, Lys109, Lys117, Lys121
  • Glycosylation2 at Ser113
  • Modification sites at PhosphoSitePlus

  • See HIST1H2BB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066406.1  
    ENSEMBL proteins: 
     ENSP00000350580  
    Reactome Protein details: P33778

    HIST1H2BB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HIST1H2BB
    OriGene Protein Over-expression Lysate for HIST1H2BB
    OriGene MassSpec for HIST1H2BB
    OriGene Custom Protein Services for HIST1H2BB
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H2BB
    Novus Biologicals HIST1H2BB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H2BB

     
    Search eBioscience for Proteins for HIST1H2BB 

     
    antibodies-online proteins for HIST1H2BB (2 products) 

     
    Search antibodies-online for peptides for HIST1H2BB

    HIST1H2BB Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for HIST1H2BB  (H2B)
    OriGene Antibodies for HIST1H2BB
    OriGene Custom Antibody Services for HIST1H2BB
    Novus Biologicals HIST1H2BB Antibodies
    Abcam antibodies for HIST1H2BB
    Cloud-Clone Corp. Antibodies for HIST1H2BB
    ThermoFisher Antibody for HIST1H2BB
    LSBio Antibodies in human, mouse, rat for HIST1H2BB
    antibodies-online antibodies for HIST1H2BB (2 products) 

    HIST1H2BB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIST1H2BB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H2BB
    Cell Signaling Technology (CST) Sandwich ELISA Kits for HIST1H2BB (H2B)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST1H2BB
    Cloud-Clone Corp. CLIAs for HIST1H2BB
    Search eBioscience for ELISAs for HIST1H2BB 
    antibodies-online kits for HIST1H2BB (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P33778

    ProtoNet protein and cluster: P33778

    UniProtKB/Swiss-Prot: H2B1B_HUMAN, P33778
    Similarity: Belongs to the histone H2B family


    Find genes that share domains with HIST1H2BB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B1B_HUMAN, P33778
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS9439656
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HIST1H2BB           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H2BB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST1H2BB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H2BB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H2BB

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST1H2BB:
    hsa-mir-652-3p (MIRT039494), hsa-mir-196a-5p (MIRT048188), hsa-mir-34a-5p (MIRT025273)

    Block miRNA regulation of human, mouse, rat HIST1H2BB using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HIST1H2BB:
    hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIST1H2BB
    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2BB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST1H2BB

    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H2BB (see all 6)
    OriGene ORF clones in mouse, rat for HIST1H2BB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H2BB (NM_021062)
    Sino Biological Human cDNA Clone for HIST1H2BB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2BB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BB
    Addgene plasmids for HIST1H2BB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIST1H2BB
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIST1H2BB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    H2B1B_HUMAN, P33778: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS9439656
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with HIST1H2BB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HIST1H2BB About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with HIST1H2BB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for HIST1H2BB
        Chromatin Regulation / Acetylation
    Apoptosis and Autophagy
    Protein Stability

    1 GeneGo (Thomson Reuters) Pathway for HIST1H2BB
        Signal transduction Activin A signaling regulation


    Selected Reactome Pathways for HIST1H2BB (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST1H2BB):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H2BB
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H2BB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H2BB (P337782, 3 ENSP000003505804) via UniProtKB, MINT, STRING, and/or I2D (see all 72)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKB2Q006532, 3MINT-48772 I2D: score=2 
    TNFRSF1AP194382, 3MINT-49364 I2D: score=2 
    TAF1P216753, ENSP000002760724I2D: score=2 STRING: ENSP00000276072
    DYRK1AQ136273, ENSP000003819324I2D: score=1 STRING: ENSP00000381932
    ERCC6Q034683, ENSP000003480894I2D: score=1 STRING: ENSP00000348089
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006334nucleosome assembly NAS9439656

    Find genes that share ontologies with HIST1H2BB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H2BB (H2B1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIST1H2BB gene: 
    NM_021062.2  

    Unigene Cluster for HIST1H2BB:

    Histone cluster 1, H2bb
    Hs.553494
    Unigene Representative Sequence: BC096728
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357905(uc003nfu.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIST1H2BB using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HIST1H2BB:
    hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIST1H2BB
    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2BB
    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H2BB (see all 6)
    OriGene ORF clones in mouse, rat for HIST1H2BB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H2BB (NM_021062)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2BB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BB
    Addgene plasmids for HIST1H2BB 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2BB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BB
      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BB
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BB

    Additional mRNA sequence: BC096728.1 

    1 DOTS entry:

    DT.92413366 

    1 AceView cDNA sequence:

    NM_021062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIST1H2BB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGTCCGA
    HIST1H2BB Expression
    About this image


    HIST1H2BB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Choroid Plexus Progenitor Cells Choroid Plexus
    HIST1H2BB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H2BB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.553494
        Custom PCR Arrays for HIST1H2BB
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2BB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BB
    QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BB
    QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for HIST1H2BB gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2bb1 , 5 histone cluster 1, H2bb1, 5 88.62(n)1
    97.62(a)1
      13 (9.90 cM)5
    3191781  NM_175664.21  NP_783595.11 
     237467905 


    ENSEMBL Gene Tree for HIST1H2BB (if available)
    TreeFam Gene Tree for HIST1H2BB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIST1H2BB gene
    HIST1H2BN2  HIST1H2BD2  HIST1H2BC2  HIST1H2BE2  HIST1H2BM2  HIST3H2BB2  HIST1H2BK2  HIST1H2BI2  
    HIST1H2BG2  HIST2H2BF2  HIST1H2BH2  HIST1H2BL2  HIST1H2BO2  HIST1H2BJ2  HIST1H2BF2  HIST2H2BE2  
    Selected SIMAP similar genes for HIST1H2BB using alignment to 1 protein entry:     H2B1B_HUMAN(see all similar genes):
    HIST1H2BD    HIST1H2BE    HIST1H2BF    HIST1H2BG    HIST1H2BH    HIST1H2BI
    HIST1H2BJ    HIST1H2BK    HIST1H2BN    HIST1H2BO    HIST2H2BE    HIST2H2BF
    HIST3H2BB    HIST1H2BC    H2BFS    HIST1H2BL    HIST1H2BM    ABCF2

    Find genes that share paralogs with HIST1H2BB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HIST1H2BB (see all 42)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790793301,2
    F--26043046(+) TTTTTG/TAGACG 1 -- ds50012Minor allele frequency- T:0.50NA 4
    rs68998611,2
    C,A,H--26043084(+) gtgccG/Atggcg 1 -- ds50013Minor allele frequency- A:0.17NA WA 6
    rs77391411,2
    C,A--26043222(+) acgggC/Gtttca 1 -- ds50010--------
    rs77389951,2
    C,A--26043250(+) gtctcC/Gatctc 1 -- ds50012Minor allele frequency- G:0.25NA 4
    rs69230351,2
    C,A--26043291(+) ccaaaG/Ttgccg 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs69003711,2
    C,A--26043295(+) attgcC/Tgggat 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs69002161,2
    C,A--26043303(+) gattaA/Caggca 1 -- ds50010--------
    rs69003901,2
    C,A--26043321(+) ccgcgA/Cacggc 1 -- ds50010--------
    rs1146061201,2
    C--26043334(+) CGTCCA/CAGTTA 1 -- ds50010--------
    rs1475422801,2
    --26043336(+) TCCAAA/GTTAAC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HIST1H2BB (26043455 - 26043885 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H2BB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509122CNV Insertion20534489
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2BB
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2BB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602803    OMIM disorders: --


    Find genes that share disorders with HIST1H2BB           About GenesLikeMe


    Export disorders for HIST1H2BB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIST1H2BB gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with HIST1H2BB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (Cell 2006)
    3. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (Mol. Cell. Biochem. 2005)
    4. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (Mol. Cell 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. (PubMed id 12757711)1, 2 Cheung W.L.... Allis C.D. (Cell 2003)
    7. Global regulation of post-translational modifications on core histones. (PubMed id 11709551)1, 2 Galasinski S.C.... Ahn N.G. (J. Biol. Chem. 2002)
    8. Association of a human H1 histone gene with an H2A pseudogene and genes encoding H2B.1 and H3.1 histones. (PubMed id 8227173)1, 3 Kardalinou E.... Doenecke D. (J. Cell. Biochem. 1993)
    9. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2 Albig W.... Doenecke D. (Genomics 1991)
    10. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3018 HGNC: 4751 AceView: HIST1H2BB Ensembl:ENSG00000196226 euGenes: HUgn3018
    ECgene: HIST1H2BB Kegg: 3018 H-InvDB: HIST1H2BB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIST1H2BB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIST1H2BB gene:
    Search GeneIP for patents involving HIST1H2BB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HIST1H2BB   OriGene RNAi products in human, mouse, rat for HIST1H2BB  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HIST1H2BB  
     OriGene MassSpec for HIST1H2BB   OriGene clones in human, mouse for HIST1H2BB  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2BB   OriGene Purified Protein for HIST1H2BB  
     OriGene ORF clones in mouse, rat for HIST1H2BB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST1H2BB   OriGene Custom Protein Services for HIST1H2BB  

     
     
     Block miRNA regulation of human, mouse, rat HIST1H2BB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIST1H2BB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2BB Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2BB
     QuantiFast Probe-based Assays in human, mouse, rat HIST1H2BB QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2BB
     Custom PCR Arrays for HIST1H2BB Search Chromatin IP Primers for HIST1H2BB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST1H2BB  Search GeneGlobe Interaction Network for HIST1H2BB
     Regulatory tfbs in HIST1H2BB promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIST1H2BB GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H2BB
     GenScript Custom Assay Services for HIST1H2BB GenScript Custom overexpressing Cell Line Services for HIST1H2BB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for HIST1H2BB  (H2B)

     Search Tocris compounds for HIST1H2BB (H2B1B)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for HIST1H2BB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HIST1H2BB antibodies
     HIST1H2BB lysates
     Antibodies for HIST1H2BB
     See all of Abcam's Antibodies, Kits and Proteins for HIST1H2BB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HIST1H2BB
     Antibodies for HIST1H2BB
     ELISAs for HIST1H2BB
     CLIAs for HIST1H2BB



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIST1H2BB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BB
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H2BB
     SwitchGear Promoter luciferase reporter plasmids for HIST1H2BB
     ThermoFisher Antibody for HIST1H2BB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2BB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H2BB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST1H2BB
     LSBio Antibodies in human, mouse, rat for HIST1H2BB
     Browse compounds at ApexBio
     Addgene plasmids for HIST1H2BB
      Search eBioscience for proteins for HIST1H2BB
      Search eBioscience for elisas for HIST1H2BB
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for HIST1H2BB (2 products)
     antibodies-online kits for HIST1H2BB (4 products)
      Search antibodies-online for peptides for HIST1H2BB
     antibodies-online proteins for HIST1H2BB (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIST1H2BB gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4