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HIST1H2BA Gene

protein-coding   GIFtS: 55
GCID: GC06P025727

Histone Cluster 1, H2ba

(Previous names: H2B histone family, member U, (testis-specific), histone...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H2ba1 2     TSH2B.12 3
TSH2B2 3 5     H2BFU2
H2B Histone Family, Member U, (Testis-Specific)1 2     STBP2
Histone 1, H2ba1 2     bA317E16.32
Histone H2B, Testis2 3     Histone H2B Type 1-A2
Testis-Specific Histone H2B2 3     

External Ids:    HGNC: 187301   Entrez Gene: 2556262   Ensembl: ENSG000001460477   OMIM: 6099045   UniProtKB: Q96A083   

Export aliases for HIST1H2BA gene to outside databases

Previous GC identifers: GC06P025785 GC06P025835 GC06P025670


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H2BA Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family.
Transcripts from this gene contain a palindromic termination element. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2BA Gene:
HIST1H2BA (histone cluster 1, H2ba) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is H2BFM.

UniProtKB/Swiss-Prot: H2B1A_HUMAN, Q96A08
Function: Variant histone specifically required to direct the transformation of dissociating nucleosomes to
protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition
and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the
large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a
similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells,
its function and the presence of post-translational modifications specific to such cells are still unclear. Core
component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the
cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex
set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2BA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H2BA gene promoter:
         Arnt   Max   PPAR-gamma1   E2F-1   E2F   ZID   PPAR-gamma2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2BA promoter sequence
   Search Chromatin IP Primers for HIST1H2BA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2BA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.2   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.2

HIST1H2BA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P025727:  view genomic region     (about GC identifiers)

Start:
25,727,137 bp from pter      End:
25,727,573 bp from pter
Size:
437 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H2B1A_HUMAN, Q96A08 (See protein sequence)
Recommended Name: Histone H2B type 1-A  
Size: 127 amino acids; 14167 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Secondary accessions: B2R544 Q6NZ98 Q6NZA0 Q6NZA1

Explore the universe of human proteins at neXtProt for HIST1H2BA: NX_Q96A08

Explore proteomics data for HIST1H2BA at MOPED

Post-translational modifications: 

  • Monoubiquitination at Lys-36 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as
    a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a
    large set of exons1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Acetylated during spermatogenesis. Acetylated form is most abundant in spermatogonia compared to spermatocytes and
    round spermatids (By similarity)1
  • Phosphorylated at Thr-117 in spermatogonia, spermatocytes and round spermatids (By similarity)1
  • Methylated at Lys-118 in spermatogonia, spermatocytes and round spermatids (By similarity)1
  • Ubiquitination2 at Lys48, Lys110, Lys118, Lys122
  • Modification sites at PhosphoSitePlus

  • See HIST1H2BA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_733759.1  
    ENSEMBL proteins: 
     ENSP00000274764  
    Reactome Protein details: Q96A08

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q96A08

    ProtoNet protein and cluster: Q96A08

    UniProtKB/Swiss-Prot: H2B1A_HUMAN, Q96A08
    Similarity: Belongs to the histone H2B family


    Find genes that share domains with HIST1H2BA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B1A_HUMAN, Q96A08
    Function: Variant histone specifically required to direct the transformation of dissociating nucleosomes to
    protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition
    and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the
    large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a
    similar role in protamine replacement by nucleosomes at fertilization (By similarity). Also found in fat cells,
    its function and the presence of post-translational modifications specific to such cells are still unclear. Core
    component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the
    cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex
    set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HIST1H2BA           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H2BA
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    miRNA
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    miRTarBase miRNAs that target HIST1H2BA:
    hsa-mir-34a-5p (MIRT025472)

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    hsa-miR-146a* hsa-miR-1276
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2B1A_HUMAN, Q96A08: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane2
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ISS--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0019897extrinsic component of plasma membrane IEA--

    Find genes that share ontologies with HIST1H2BA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H2BA About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Chromosome Maintenance0.62
    Meiotic Synapsis0.66
    Nucleosome assembly0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Telomere Maintenance0.64
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with HIST1H2BA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HIST1H2BA
        FOXM1 transcription factor network

    Selected Reactome Pathways for HIST1H2BA (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    3 Kegg Pathways  (Kegg details for HIST1H2BA):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H2BA
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H2BA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H2BA (Q96A082, 3 ENSP000002747644) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD7Q9NPI12, 3, ENSP000003781804MINT-6665455 I2D: score=1 STRING: ENSP00000378180
    DNTTIP2Q5QJE63, ENSP000003521374I2D: score=1 STRING: ENSP00000352137
    HIST2H2ACQ167773, ENSP000003321944I2D: score=1 STRING: ENSP00000332194
    SETQ011053, ENSP000003617774I2D: score=1 STRING: ENSP00000361777
    CCNA1P783963, ENSP000002554654I2D: score=1 STRING: ENSP00000255465
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006334nucleosome assembly ISS--
    GO:0006337nucleosome disassembly ISS--
    GO:0006954inflammatory response IEA--
    GO:0031639plasminogen activation IEA--

    Find genes that share ontologies with HIST1H2BA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H2BA (H2B1A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIST1H2BA gene: 
    NM_170610.2  

    Unigene Cluster for HIST1H2BA:

    Histone cluster 1, H2ba
    Hs.591786  [show with all ESTs]
    Unigene Representative Sequence: CF272078
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274764(uc003nfd.3)
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    Additional mRNA sequence: 

    AK312055.1 BC066238.1 BC066239.1 BC066240.1 BC066241.1 BC066242.1 BC066243.1 

    2 DOTS entries:

    DT.102822349  DT.70103985 

    Selected AceView cDNA sequences (see all 37):

    NM_170610 BE503453 AW082675 BC066243 BC066239 AI932318 AA905660 BC066238 
    AI017769 AW074857 BC066242 BC066240 BI828816 CF272073 AI216007 CK130251 
    AA405061 CF272084 BX118941 BC066241 AI336833 AW663216 AA994747 CF272083 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H2BA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGTCTGA
    HIST1H2BA Expression
    About this image


    HIST1H2BA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    HIST1H2BA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H2BA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591786

    UniProtKB/Swiss-Prot: H2B1A_HUMAN, Q96A08
    Tissue specificity: Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at
    protein level). Also found in some fat cells

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2BA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HIST1H2BA gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2ba1 , 5 histone cluster 1, H2ba1, 5 80.31(n)1
    94.49(a)1
      13 (10.00 cM)5
    3191771  NM_175663.11  NP_783594.11 
     239337735 
    chicken
    (Gallus gallus)
    Aves --
    Histone H2B
    73(a)
    1 → many
    2(142049-143378)
    zebrafish
    (Danio rerio)
    Actinopterygii HIST1H2BA6
    histone cluster 1, H2ba
    86(a)
    1 → many
    25(36196978-36197569) ENSDARG00000089039
    fruit fly
    (Drosophila melanogaster)
    Insecta His2B:CG339006
    His2B:CG33900
    82(a)
    many ↔ many
    2L(21457449-21458003)
    worm
    (Caenorhabditis elegans)
    Secernentea his-346
    his-666
    (see all 17)
    Protein HIS-58 (his-58) mRNA, complete cds
    (see all 17)
    80(a)
    80(a)
    (see all 17)
    many ↔ many
    many ↔ many
    (see all 17)
    IV(8335972-8336340) WBGene00001908
    IV(11400415-11400786) WBGene00001940
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HTB16
    HTB26
    Histone H2B, core histone protein required for chr...
    Histone H2B, core histone protein required for chr...
    66(a)
    66(a)
    many ↔ many
    many ↔ many
    IV(914317-914712) YDR224C
    II(236492-236887) YBL002W


    ENSEMBL Gene Tree for HIST1H2BA (if available)
    TreeFam Gene Tree for HIST1H2BA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H2BA gene
    H2BFM2  H2BFWT2  
    Selected SIMAP similar genes for HIST1H2BA using alignment to 1 protein entry:     H2B1A_HUMAN(see all similar genes):
    ABCF2    HIST1H2BL    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF
    HIST1H2BG    HIST1H2BH    HIST1H2BI    HIST1H2BJ    HIST1H2BK    HIST1H2BN
    HIST1H2BO    HIST2H2BE    HIST2H2BF    HIST1H2BC    H2BFS    HIST1H2BM

    Find genes that share paralogs with HIST1H2BA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for HIST1H2BA (see all 25)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832653141,2
    --25725175(+) CTTTAC/TCTGCT 1 -- us2k10--------
    rs93797831,2
    C,F,A,H--25725207(+) GTAGAC/TATCAA 1 -- us2k126Minor allele frequency- T:0.38NA EA NS WA 3084
    rs1164387431,2
    C,F--25725213(+) ATCAAG/ATGTTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1385704121,2
    C--25725223(+) AGCAG-/TTTTTT 1 -- us2k10--------
    rs1151902761,2
    C--25725234(+) TTTTTG/TGTAAC 1 -- us2k10--------
    rs562447461,2
    C--25725246(+) AATGA-/GTTT  
            
    TTTTT
    1 -- us2k10--------
    rs787559491,2
    C--25725247(+) AATGAG/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1432613981,2
    --25725265(+) TGAGGC/TAAGGT 1 -- us2k10--------
    rs2006748361,2
    --25725275(+) TCAAC-/TGTTGAAT 1 -- us2k10--------
    rs1475064641,2
    C--25725393(+) AAACTA/GTTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2BA (25727137 - 25727573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H2BA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883488CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2BA
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2BA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609904    OMIM disorders: --


    Find genes that share disorders with HIST1H2BA           About GenesLikeMe

    Genetic Association Database (GAD): HIST1H2BA

    Export disorders for HIST1H2BA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H2BA gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with HIST1H2BA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization. (PubMed id 12213818)1, 2, 3 Zalensky A.O.... Bradbury E.M. (J. Biol. Chem. 2002)
    3. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (Cell 2006)
    4. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (Mol. Cell. Biochem. 2005)
    5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (Mol. Cell 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 255626 HGNC: 18730 AceView: HIST1H2BA Ensembl:ENSG00000146047 euGenes: HUgn255626
    ECgene: HIST1H2BA Kegg: 255626 H-InvDB: HIST1H2BA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H2BA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H2BA gene:
    Search GeneIP for patents involving HIST1H2BA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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