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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2BA Gene

protein-coding   GIFtS: 53
GCID: GC06P025727

Histone Cluster 1, H2ba

(Previous names: H2B histone family, member U, (testis-specific), histone...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H2ba1 2     Testis-Specific Histone H2B2 3
TSH2B2 3 5     H2BFU2
H2B Histone Family, Member U, (Testis-Specific)1 2     STBP2
Histone 1, H2ba1 2     bA317E16.32
Histone H2B, Testis2 3     Histone H2B Type 1-A2

External Ids:    HGNC: 187301   Entrez Gene: 2556262   Ensembl: ENSG000001460477   OMIM: 6099045   UniProtKB: Q96A083   

Export aliases for HIST1H2BA gene to outside databases

Previous GC identifers: GC06P025785 GC06P025835 GC06P025670


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2BA Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family.
Transcripts from this gene contain a palindromic termination element. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2BA Gene: 
HIST1H2BA (histone cluster 1, H2ba) is a protein-coding gene. Diseases associated with HIST1H2BA include papillary adenoma, and systemic lupus erythematosus, and among its related super-pathways are Telomere Maintenance and Meiosis. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is H2BFM.

UniProtKB/Swiss-Prot: H2B1A_HUMAN, Q96A08
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2BA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2BA gene promoter:
         Arnt   Max   PPAR-gamma1   E2F-1   E2F   ZID   PPAR-gamma2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2BA promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2BA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2BA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.2   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.2

HIST1H2BA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2BA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P025727:  view genomic region     (about GC identifiers)

Start:
25,727,137 bp from pter      End:
25,727,573 bp from pter
Size:
437 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H2B1A_HUMAN, Q96A08 (See protein sequence)
Recommended Name: Histone H2B type 1-A  
Size: 127 amino acids; 14167 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Secondary accessions: B2R544 Q6NZ98 Q6NZA0 Q6NZA1

Explore the universe of human proteins at neXtProt for HIST1H2BA: NX_Q96A08

Explore proteomics data for HIST1H2BA at MOPED 

Post-translational modifications:

  • UniProtKB: Monoubiquitination at Lys-36 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and
    'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.
    Similarly, monoubiquitination at Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic
    transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also
    functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96A08

  • HIST1H2BA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H2BA Protein Expression
    REFSEQ proteins: NP_733759.1  
    ENSEMBL proteins: 
     ENSP00000274764  
    Reactome Protein details: Q96A08
    Human Recombinant Protein Products for HIST1H2BA: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ISS--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0019897extrinsic to plasma membrane IEA--

    HIST1H2BA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR000558 Histone_H2B
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry Q96A08

    ProtoNet protein and cluster: Q96A08

    UniProtKB/Swiss-Prot: H2B1A_HUMAN, Q96A08
    Similarity: Belongs to the histone H2B family


    HIST1H2BA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2B1A_HUMAN, Q96A08
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    HIST1H2BA for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H2BA About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.56
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    Telomere Maintenance0.56
    Amyloids0.41
    Nucleosome assembly0.46
    2Meiotic Synapsis
    Meiotic Synapsis0.70
    Meiotic Recombination0.62
    Meiosis0.70
    Chromosome Maintenance0.56
    3Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    4Cell Cycle
    Cell Cycle0.84
    5Viral carcinogenesis
    Viral carcinogenesis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HIST1H2BA
        FOXM1 transcription factor network

    5/11        Reactome Pathways for HIST1H2BA (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    3         Kegg Pathways  (Kegg details for HIST1H2BA):
        Alcoholism
    Viral carcinogenesis
    Systemic lupus erythematosus


    HIST1H2BA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2BA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/28 Interacting proteins for HIST1H2BA (Q96A082, 3 ENSP000002747644) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD7Q9NPI12, 3, ENSP000003781804MINT-6665455 I2D: score=1 STRING: ENSP00000378180
    DNTTIP2Q5QJE63, ENSP000003521374I2D: score=1 STRING: ENSP00000352137
    HIST2H2ACQ167773, ENSP000003321944I2D: score=1 STRING: ENSP00000332194
    SETQ011053, ENSP000003617774I2D: score=1 STRING: ENSP00000361777
    CCNA1P783963, ENSP000002554654I2D: score=1 STRING: ENSP00000255465
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ISS--
    GO:0006337nucleosome disassembly ISS--
    GO:0006954inflammatory response IEA--
    GO:0031639plasminogen activation IEA--
    GO:0035093spermatogenesis, exchange of chromosomal proteins ISS--

    HIST1H2BA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2BA (H2B1A)

    Search CenterWatch for drugs/clinical trials and news about HIST1H2BA / H2B1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H2BA gene: 
    NM_170610.2  

    Unigene Cluster for HIST1H2BA:

    Histone cluster 1, H2ba
    Hs.591786  [show with all ESTs]
    Unigene Representative Sequence: CF272078
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000274764(uc003nfd.3)
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    Additional mRNA sequence: 

    AK312055.1 BC066238.1 BC066239.1 BC066240.1 BC066241.1 BC066242.1 BC066243.1 

    2 DOTS entries:

    DT.102822349  DT.70103985 

    24/37 AceView cDNA sequences (see all 37):

    BE503453 NM_170610 BC066238 AI932318 AI017769 BC066243 BC066240 BI828816 
    CF272073 AW074857 AA905660 AW082675 BC066242 BC066239 BC066241 AI216007 
    AA405061 BX118941 CK130251 CF272084 AA609552 AW293230 AW663216 BG220323 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2BA expression in normal human tissues (normalized intensities)      HIST1H2BA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTGTCTGA
    HIST1H2BA Expression
    About this image


    HIST1H2BA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Lung (Respiratory System)
             lung ; macrophages   
     
     Adrenal Gland (Endocrine System)
             adrenal gland ; glandular cells   
     
     Blood (Respiratory System)
             lung ; macrophages   

    See HIST1H2BA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2BA

    SOURCE GeneReport for Unigene cluster: Hs.591786

    UniProtKB/Swiss-Prot: H2B1A_HUMAN, Q96A08
    Tissue specificity: Transcribed exclusively in testis, and the corresponding protein is also present in mature
    sperm

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HIST1H2BA gene from 5/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2ba5 histone cluster 1, H2ba   --   13 (10.00 cM) 23933773 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    83(a)
    83(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    GL343466.1(265902-266282)
    GL343466.1(243009-243389)
    zebrafish
    (Danio rerio)
    Actinopterygii HIST1H2BA6
    histone cluster 1, H2ba
    65(a)
    1 ↔ 1
    7(76814613-76821072)
    worm
    (Caenorhabditis elegans)
    Secernentea his-416
    his-296
    (see all 11)
    Histone H2B 1
    (see all 11)
    80(a)
    79(a)
    (see all 11)
    1 ↔ many
    1 ↔ many
    (see all 11)
    V(9545522-9546265)
    IV(8331044-8331412)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HTB16
    HTB26
    Histone H2B, core histone protein required for chr...
    Histone H2B, core histone protein required for chr...
    64(a)
    64(a)
    many ↔ many
    many ↔ many
    IV(914317-914712)
    II(236492-236887)


    ENSEMBL Gene Tree for HIST1H2BA (if available)
    TreeFam Gene Tree for HIST1H2BA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2BA gene
    H2BFM2  H2BFWT2  
    18/23 SIMAP similar genes for HIST1H2BA using alignment to 1 protein entry:     H2B1A_HUMAN(see all similar genes):
    ABCF2    HIST1H2BL    HIST1H2BB    HIST1H2BD    HIST1H2BE    HIST1H2BF
    HIST1H2BG    HIST1H2BH    HIST1H2BI    HIST1H2BJ    HIST1H2BK    HIST1H2BN
    HIST1H2BO    HIST2H2BE    HIST2H2BF    HIST1H2BC    H2BFS    HIST1H2BM

    HIST1H2BA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/25 SNPs in HIST1H2BA are shown (see all 25)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1832653141,2
    --25725175(+) CTTTAC/TCTGCT 1 -- us2k10--------
    rs93797831,2
    C,F,A,H--25725207(+) GTAGAC/TATCAA 1 -- us2k126Minor allele frequency- T:0.38NA EA NS WA 3084
    rs1164387431,2
    C,F--25725213(+) ATCAAG/ATGTTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1385704121,2
    C--25725223(+) AGCAG-/TTTTTT 1 -- us2k10--------
    rs1151902761,2
    C--25725234(+) TTTTTG/TGTAAC 1 -- us2k10--------
    rs562447461,2
    C--25725246(+) AATGA-/GTTT  
            
    TTTTT
    1 -- us2k10--------
    rs787559491,2
    C--25725247(+) AATGAG/TTTTTT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1432613981,2
    --25725265(+) TGAGGC/TAAGGT 1 -- us2k10--------
    rs2006748361,2
    --25725275(+) TCAAC-/TGTTGAAT 1 -- us2k10--------
    rs1475064641,2
    C--25725393(+) AAACTA/GTTTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2BA (25727137 - 25727573 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H2BA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883488CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609904    OMIM disorders: --

    4 diseases for HIST1H2BA:    About MalaCards
    papillary adenoma    systemic lupus erythematosus    lupus erythematosus    adenoma


    HIST1H2BA for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIST1H2BA

    Export disorders for HIST1H2BA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2BA gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with HIST1H2BA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human testis/sperm-specific histone H2B (hTSH2B). Molecular cloning and characterization. (PubMed id 12213818)1, 2, 3 Zalensky A.O.... Bradbury E.M. (2002)
    3. Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (PubMed id 16713563)1, 2 Pavri R....Reinberg D. (2006)
    4. Inhibition of core histones acetylation by carcinogenic nickel(II). (PubMed id 16283522)1, 2 Golebiowski F. and Kasprzak K.S. (2005)
    5. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. (PubMed id 16307923)1, 2 Zhu B.... Reinberg D. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 255626 HGNC: 18730 AceView: HIST1H2BA Ensembl:ENSG00000146047 euGenes: HUgn255626
    ECgene: HIST1H2BA Kegg: 255626 H-InvDB: HIST1H2BA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2BA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H2BA gene:
    Search GeneIP for patents involving HIST1H2BA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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