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HIST1H2AL Gene

protein-coding   GIFtS: 55
GCID: GC06P027843

Histone Cluster 1, H2al

(Previous names: H2A histone family, member I, histone 1, H2al)
(Previous symbol: H2AFI)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H2al1 2     dJ193B12.92
H2AFI1 2 3 5     Histone H2A Type 12
H2A Histone Family, Member I1 2     H2AFC3
Histone 1, H2al1 2     H2AFD3
H2A.12 3     H2AFN3
H2A.i2     H2AFP3
H2A/i2     Histone H2A/P3

External Ids:    HGNC: 47301   Entrez Gene: 83322   Ensembl: ENSG000001983747   OMIM: 6027935   UniProtKB: P0C0S83   

Export aliases for HIST1H2AL gene to outside databases

Previous GC identifers: GC06P027891 GC06P027941 GC06P027640


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H2AL Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster
on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2AL Gene:
HIST1H2AL (histone cluster 1, H2al) is a protein-coding gene. Diseases associated with HIST1H2AL include riddle syndrome, and systemic lupus erythematosus. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2AL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H2AL gene promoter:
         E2F-3a   E2F-4   E2F-5   Tal-1   Brachyury   E2F-2   E47   E2F-1   E2F   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2AL promoter sequence
   Search Chromatin IP Primers for HIST1H2AL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2AL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2AL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027843:  view genomic region     (about GC identifiers)

Start:
27,833,034 bp from pter      End:
27,833,606 bp from pter
Size:
573 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8 (See protein sequence)
Recommended Name: Histone H2A type 1  
Size: 130 amino acids; 14091 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Mass spectrometry: Mass=13993.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: P02261 Q2M1R2 Q76PA6

Explore the universe of human proteins at neXtProt for HIST1H2AL: NX_P0C0S8

Explore proteomics data for HIST1H2AL at MOPED

Post-translational modifications: 

  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly
    represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at
    Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates
    their transcription1
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)1
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at
    35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIST1H2AL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003502.1  
    ENSEMBL proteins: 
     ENSP00000349873  
    Reactome Protein details: P0C0S8

    HIST1H2AL Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P0C0S8

    ProtoNet protein and cluster: P0C0S8

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
    Similarity: Belongs to the histone H2A family


    HIST1H2AL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A1_HUMAN, P0C0S8
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0005515protein binding ----
    GO:0019899enzyme binding ----
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H2AL for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HIST1H2AL:
     Increased G2M DNA content, inc  Increased gamma-H2AX phosphory  Metaphase cells 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target HIST1H2AL:
    hsa-mir-10b-5p (MIRT047436), hsa-mir-34a-5p (MIRT025349)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2A1_HUMAN, P0C0S8: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005622intracellular ----
    GO:0005634nucleus ----

    HIST1H2AL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H2AL About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40
    Chromatin organization0.34
    HATs acetylate histones0.34
    Alcoholism0.34
    Chromatin modifying enzymes0.34
    2Packaging Of Telomere Ends
    Signal transduction Activin A signaling regulation0.40
    Histone modification0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2AL
        Signal transduction Activin A signaling regulation

    1 Reactome Pathway for HIST1H2AL
        HATs acetylate histones


    2 Kegg Pathways  (Kegg details for HIST1H2AL):
        Alcoholism
    Systemic lupus erythematosus


    HIST1H2AL for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H2AL
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H2AL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for HIST1H2AL (P0C0S81, 2, 3 ENSP000003498734) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL33O957601, 2, 3EBI-1390628,EBI-724057 MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    YWHAZP631041, 2, 3EBI-1390628,EBI-347088 MINT-3296701 MINT-7899812 I2D: score=1 
    RYBPQ8N4882, 3MINT-3973842 MINT-3973898 I2D: score=1 
    YWHAQP273482, 3MINT-7899812 I2D: score=1 
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----

    HIST1H2AL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H2AL (H2A1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H2AL gene: 
    NM_003511.2  

    Unigene Cluster for HIST1H2AL:

    Histone cluster 1, H2al
    Hs.233568  [show with all ESTs]
    Unigene Representative Sequence: BC105129
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357320(uc003njw.3)
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      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AL
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AL

    Additional mRNA sequence: 

    BC069306.1 BC105129.1 BC112072.1 

    1 DOTS entry:

    DT.100684472 

    3 AceView cDNA sequences:

    BC069306 NM_003511 AI200373 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H2AL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGGACGCG
    HIST1H2AL Expression
    About this image


    HIST1H2AL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
    HIST1H2AL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H2AL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.233568
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2AL gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2af5
    Hist1h2ae1
    histone cluster 1, H2af5
    histone cluster 1, H2ae1
    89.74(n)1
    98.46(a)1
      13 (9.77 cM)5
    3191661  NM_178187.31  NP_835494.11 
     235339065 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Histone H2A
    99(a)
    99(a)
    many ↔ many
    many ↔ many
    GL343220.1(86772-87161)
    GL343466.1(242198-242587)
    soybean
    (Glycine max)
    eudicotyledons Gma.54432 Transcribed sequence with strong similarity to protein more 75.17(n)    CA851811.1 


    ENSEMBL Gene Tree for HIST1H2AL (if available)
    TreeFam Gene Tree for HIST1H2AL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H2AL gene
    HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  
    HIST1H2AH2  HIST1H2AM2  HIST1H2AJ2  HIST1H2AA2  HIST2H2AA42  HIST1H2AE2  HIST1H2AB2  HIST2H2AC2  
    HIST1H2AK2  H2AFJ2  
    Selected SIMAP similar genes for HIST1H2AL using alignment to 1 protein entry:     H2A1_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AH    HIST1H2AJ
    HIST1H2AK    HIST2H2AA3    HIST2H2AA4    HIST3H2A    H2AFJ    HIST1H2AA
    HIST2H2AB    HIST2H2AC    H2AFX    HIST1H2APS4    H2AFZ    H2AFB2

    HIST1H2AL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H2AL (see all 94)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009821,2
    C,F,A,H--27831244(-) AGAAAG/AAGGAA 1 -- us2k1 trp312Minor allele frequency- A:0.04MN NS EA NA WA 1040
    rs1453275851,2
    --27831410(+) TGTAAC/GCTGCA 1 -- us2k10--------
    rs1919338051,2
    --27831465(+) TTAAAC/TACTTG 1 -- us2k10--------
    rs1828478531,2
    --27831540(+) TCGCAC/TAATAA 1 -- us2k10--------
    rs1865557611,2
    --27831552(+) ACTCCC/TGTTTT 1 -- us2k10--------
    rs1896782561,2
    --27831563(+) GTGTAC/TTTGAC 1 -- us2k10--------
    rs737408551,2
    C,F--27831565(+) GTATTT/GGACGT 1 -- us2k13Minor allele frequency- G:0.04WA CSA 122
    rs1824298391,2
    --27831707(+) ATAAAC/TGAGCG 1 -- us2k10--------
    rs733866321,2
    C,F--27831708(+) TAAACG/TAGCGT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1405784001,2
    C--27831750(+) AAAAGA/GGTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2AL (27833034 - 27833606 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H2AL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2AL
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2AL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602793    OMIM disorders: --

    5 diseases for HIST1H2AL:    
    About MalaCards
    riddle syndrome    systemic lupus erythematosus    hiv-1    lupus erythematosus
    endotheliitis


    HIST1H2AL for disorders           About GeneDecksing


    Export disorders for HIST1H2AL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H2AL gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with HIST1H2AL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (Hum. Genet. 1997)
    3. The human H2A and H2B histone gene complement. (PubMed id 10064132)1, 2 Albig W.... Doenecke D. (Biol. Chem. 1999)
    4. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PubMed id 9031620)1, 3 Albig W.... Doenecke D. (Gene 1997)
    5. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. (PubMed id 24352239)2 Tessarz P.... Kouzarides T. (Nature 2014)
    6. VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. (PubMed id 24140421)2 Kim K.... An W. (Mol. Cell 2013)
    7. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (Cell Cycle 2012)
    8. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (Cell 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8332 HGNC: 4730 AceView: HIST1H2AL Ensembl:ENSG00000198374 euGenes: HUgn8332
    ECgene: HIST1H2AL Kegg: 8332 H-InvDB: HIST1H2AL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H2AL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H2AL gene:
    Search GeneIP for patents involving HIST1H2AL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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