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Aliases for HIST1H2AL Gene

Aliases for HIST1H2AL Gene

  • Histone Cluster 1, H2al 2 3
  • H2AFI 3 4 6
  • H2A Histone Family, Member I 2 3
  • Histone 1, H2al 2 3
  • H2A.1 3 4
  • HIST1H2AG HIST1H2AI HIST1H2AK HIST1H2AL HIST1H2AM 4
  • Histone H2A Type 1 3
  • Histone H2A/P 4
  • DJ193B12.9 3
  • H2AFP 4
  • H2AFC 4
  • H2AFD 4
  • H2AFN 4
  • H2A.I 3
  • H2A/I 3

External Ids for HIST1H2AL Gene

Previous HGNC Symbols for HIST1H2AL Gene

  • H2AFI

Previous GeneCards Identifiers for HIST1H2AL Gene

  • GC06P027891
  • GC06P027941
  • GC06P027843
  • GC06P027640

Summaries for HIST1H2AL Gene

Entrez Gene Summary for HIST1H2AL Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2AL Gene

HIST1H2AL (Histone Cluster 1, H2al) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening.

UniProtKB/Swiss-Prot for HIST1H2AL Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AL Gene

Genomics for HIST1H2AL Gene

Regulatory Elements for HIST1H2AL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST1H2AL Gene

Start:
27,865,329 bp from pter
End:
27,865,798 bp from pter
Size:
470 bases
Orientation:
Plus strand

Genomic View for HIST1H2AL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2AL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AL Gene

Proteins for HIST1H2AL Gene

  • Protein details for HIST1H2AL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0S8-H2A1_HUMAN
    Recommended name:
    Histone H2A type 1
    Protein Accession:
    P0C0S8
    Secondary Accessions:
    • P02261
    • Q2M1R2
    • Q76PA6

    Protein attributes for HIST1H2AL Gene

    Size:
    130 amino acids
    Molecular mass:
    14091 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

    Three dimensional structures from OCA and Proteopedia for HIST1H2AL Gene

neXtProt entry for HIST1H2AL Gene

Proteomics data for HIST1H2AL Gene at MOPED

Post-translational modifications for HIST1H2AL Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys14, Lys16, Lys96, Lys100, and Lys119
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST1H2AL Gene

Domains for HIST1H2AL Gene

Gene Families for HIST1H2AL Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2AL Gene

Graphical View of Domain Structure for InterPro Entry

P0C0S8

UniProtKB/Swiss-Prot:

H2A1_HUMAN :
  • P0C0S8
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AL: view

No data available for Suggested Antigen Peptide Sequences for HIST1H2AL Gene

Function for HIST1H2AL Gene

Molecular function for HIST1H2AL Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15161933
GO:0019899 enzyme binding IPI 17980597
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with HIST1H2AL: view

Phenotypes for HIST1H2AL Gene

genes like me logo Genes that share phenotypes with HIST1H2AL: view

miRNA for HIST1H2AL Gene

miRTarBase miRNAs that target HIST1H2AL

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2AL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2AL Gene

Localization for HIST1H2AL Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AL Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2AL Gene COMPARTMENTS Subcellular localization image for HIST1H2AL gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HIST1H2AL: view

Pathways for HIST1H2AL Gene

genes like me logo Genes that share pathways with HIST1H2AL: view

Pathways by source for HIST1H2AL Gene

2 KEGG pathways for HIST1H2AL Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2AL Gene

Gene Ontology (GO) - Biological Process for HIST1H2AL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HIST1H2AL: view

Transcripts for HIST1H2AL Gene

mRNA/cDNA for HIST1H2AL Gene

(3) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AL Gene

Histone cluster 1, H2al:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2AL

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AL Gene

No ASD Table

Relevant External Links for HIST1H2AL Gene

GeneLoc Exon Structure for
HIST1H2AL
ECgene alternative splicing isoforms for
HIST1H2AL

Expression for HIST1H2AL Gene

mRNA expression in normal human tissues for HIST1H2AL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2AL Gene

This gene is overexpressed in Whole Blood (14.4).

Protein differential expression in normal tissues for HIST1H2AL Gene

This gene is overexpressed in Saliva (40.4) and Heart (18.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HIST1H2AL Gene

SOURCE GeneReport for Unigene cluster for HIST1H2AL Gene Hs.233568

genes like me logo Genes that share expressions with HIST1H2AL: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H2AL Gene

Orthologs for HIST1H2AL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H2AL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC524176 35
  • 91.28 (n)
  • 99.23 (a)
mouse
(Mus musculus)
Mammalia Hist1h2ae 35
  • 89.74 (n)
  • 98.46 (a)
Hist1h2af 16
chimpanzee
(Pan troglodytes)
Mammalia LOC471894 35
  • 91.54 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Hist1h2ah 35
  • 86.92 (n)
  • 99.23 (a)
soybean
(Glycine max)
eudicotyledons Gma.5443 35
Species with no ortholog for HIST1H2AL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AL Gene

ENSEMBL:
Gene Tree for HIST1H2AL (if available)
TreeFam:
Gene Tree for HIST1H2AL (if available)

Paralogs for HIST1H2AL Gene

genes like me logo Genes that share paralogs with HIST1H2AL: view

No data available for Paralogs for HIST1H2AL Gene

Variants for HIST1H2AL Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs172083 -- 27,866,027(+) AAAAA(A/C)ATCCA downstream-variant-500B
rs200981 -- 27,865,396(-) TTGGC(C/T)TTGGC reference, synonymous-codon
rs200982 -- 27,863,466(-) AGAAA(A/G)AGGAA upstream-variant-2KB
rs2200870 -- 27,864,940(-) cctga(A/G)tagct upstream-variant-2KB
rs9368535 -- 27,865,922(+) AGGTG(A/T)CATGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AL Gene

Variant ID Type Subtype PubMed ID
nsv883512 CNV Gain 21882294

Relevant External Links for HIST1H2AL Gene

HapMap Linkage Disequilibrium report
HIST1H2AL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AL Gene

Disorders for HIST1H2AL Gene

No disorders were found for HIST1H2AL Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HIST1H2AL Gene

Publications for HIST1H2AL Gene

  1. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PMID: 9031620) Albig W. … Doenecke D. (Gene 1997) 2 3
  4. The human H2A and H2B histone gene complement. (PMID: 10064132) Albig W. … Doenecke D. (Biol. Chem. 1999) 3 4
  5. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne M.T. II … Kelleher N.L. (J. Proteome Res. 2006) 3 4

Products for HIST1H2AL Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2AL
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2AL
  • Block miRNA regulation of HIST1H2AL using miScript Target Protectors

Sources for HIST1H2AL Gene

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