Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2AK Gene

protein-coding   GIFtS: 52
GCID: GC06M027807

histone cluster 1, H2ak

(Previous names: H2A histone family, member D, histone 1, H2ak )
(Previous symbol: H2AFD)
 Explore 4 diseases affiliated with
HIST1H2AK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H2AK    

Aliases
for HIST1H2AK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H2ak1 2     Histone H2A Type 1-J2
H2AFD1 2 3 5     H2AFC3
H2A/D1     H2AFI3
H2A Histone Family, Member D1 2     H2AFN3
Histone 1, H2ak1 2     H2AFP3
H2A.12 3     Histone H2A/P3
Histone H2A Type 12     HIST1H2AI5

External Ids:    HGNC: 47261   Entrez Gene: 83302   Ensembl: ENSG000001843487   OMIM: 6027885   UniProtKB: P0C0S83   

Export aliases for HIST1H2AK gene to outside databases

Previous GC identifers: GC06M027863 GC06M027913 GC06M027613


Summaries
for HIST1H2AK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H2AK:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome
6p22-p21.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AK


Genomic Views
for HIST1H2AK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2AK gene promoter:
         AhR   AML1a   XBP-1   Arnt   E47   HEN1   CREB   FOXO4   deltaCREB   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H2AK promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2AK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2AK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2AK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027807:  view genomic region     (about GC identifiers)

Start:
 27,805,626 bp from pter      End:
 27,806,124 bp from pter
Size:
 499 bases      Orientation:
 minus strand

Proteins
for HIST1H2AK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8 (See protein sequence)
Recommended Name: Histone H2A type 1  
Size: 130 amino acids; 14091 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=13993.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: P02261 Q2M1R2 Q76PA6

Explore the universe of human proteins at neXtProt for HIST1H2AK: NX_P0C0S8

Post-translational modifications:

  • The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    • transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by
    RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks
    (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases
    RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and
    Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates
    monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able
    to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked
    ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    • transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    • similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2 (H2AE)
  • View neXtProt modification sites for NX_P0C0S8

    • HIST1H2AK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003501.1  
    ENSEMBL proteins: 
     ENSP00000330307  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for HIST1H2AK 
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H2AK
    Novus Biologicals HIST1H2AK Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H2AK

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005634nucleus IEA--


    HIST1H2AK for ontologies           About GeneDecksing



    HIST1H2AK Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H2AK
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST1H2AK 
    GenScript Custom Superior Antibodies Services for HIST1H2AK
    Search for Antibodies for HIST1H2AK at Abcam  
    Uscn Antibodies for HIST1H2AK
    ThermoFisher Antibody for HIST1H2AK

    Assay Products for HIST1H2AK: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H2AK
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HIST1H2AK

    Protein Domains /
    Families
    for HIST1H2AK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H2AK for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P0C0S8

    ProtoNet protein and cluster: P0C0S8

    1 Blocks protein family: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
    Similarity: Belongs to the histone H2A family


    Function
    for HIST1H2AK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HIST1H2AK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H2AK
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H2AK:
    hsa-miR-146a* hsa-miR-659
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2AK (see all 4)
    OriGene shRNA RFP: HIST1H2AK
    OriGene siRNA: HIST1H2AK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2AK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HIST1H2AK

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2AK (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2AK
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HIST1H2AK (NM_003510)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2AK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2AK 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HIST1H2AK
    Search LifeMap BioReagents cell lines for HIST1H2AK

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2AK

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0019899enzyme binding ----
    GO:0046982protein heterodimerization activity IEA--


    HIST1H2AK for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HIST1H2AK:
     Synthetic lethal with c-Myc af 


    Pathways & Interactions
    for HIST1H2AK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    2Systemic lupus erythematosus
    		Systemic lupus erythematosus1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2AK
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2AK
        Signal transduction Activin A signaling regulation


    1         Kegg Pathway  (Kegg details for HIST1H2AK):
        Systemic lupus erythematosus


    HIST1H2AK for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2AK

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/85 Interacting proteins for HIST1H2AK (P0C0S82, 3 ENSP000003303074) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL33O957602, 3MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    RYBPQ8N4882, 3MINT-3973842 MINT-3973898 I2D: score=1 
    YWHAZP631042, 3MINT-3296701 MINT-7899812 I2D: score=1 
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=1 STRING: ENSP00000238081
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--


    HIST1H2AK for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H2AK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2AK
    Search CenterWatch for drugs/clinical trials and news about HIST1H2AK / H2A1 

    Transcripts
    for HIST1H2AK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H2AK gene: 
    NM_003510.2  

    Unigene Cluster for HIST1H2AK:

    Histone cluster 1, H2ak
    Hs.734717  [show with all ESTs]
    Unigene Representative Sequence: BC034487
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330180(uc003njs.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HIST1H2AK
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H2AK
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H2AK:
    hsa-miR-146a* hsa-miR-659
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2AK (see all 4)
    OriGene shRNA RFP: HIST1H2AK
    OriGene siRNA: HIST1H2AK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2AK
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2AK (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2AK
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HIST1H2AK (NM_003510)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2AK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2AK 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H2AK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIST1H2AK
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AK
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AK

    Additional cDNA sequence: 

    AK130106.1 AK311941.1 BC034487.2 BC104198.1 BC104199.1 

    1 DOTS entry:

    DT.40223907 

    15 AceView cDNA sequences:

    NM_003510 H54606 BP341166 BF061074 BG722363 AI366817 BX098128 BF439498 
    BI524579 AI809266 BC034487 BQ300928 AI424840 AI809131 H54717 

    GeneLoc Exon Structure


    Expression
    for HIST1H2AK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2AK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST1H2AK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

    See HIST1H2AK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2AK

    SOURCE GeneReport for Unigene cluster: Hs.734717
        SABiosciences Custom PCR Arrays for HIST1H2AK
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H2AK
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIST1H2AK
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AK
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AK
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2AK

    Orthologs
    for HIST1H2AK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2AK gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    HIST1H2AA6
    		 --
    		 83(a)
    60(a)
    		 possible ortholog
    possible ortholog
    		 GL343252.1(1819594-1819782)
    GL344481.1(11179-11601)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BJ616599.12   -- 78.8(n)    BJ616599.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii FP236812.46
    CR762436.46
    (see all 31)    		 --
    		 95(a)
    95(a)
    (see all 31)    		 possible ortholog
    possible ortholog
    (see all 31)    		 7(76856718-76857104)
    25(36201662-36202048)
    fruit fly
    (Drosophila melanogaster)    		 Insecta His2A:CG338656
    His2A:CG338176
    (see all 20)    		 His2A:CG33817
    (see all 20)    		 88(a)
    88(a)
    (see all 20)    		 possible ortholog
    possible ortholog
    (see all 20)    		 2L(21538245-21538813)
    2L(21458012-21458580)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 Core histone H2A/H2B/H3/H4 domain containing prote...
    		 15(a)
    		 1 → many
    		 4(7540547-7546903)


    ENSEMBL Gene Tree for HIST1H2AK (if available)
    TreeFam Gene Tree for HIST1H2AK (if available) 

    Paralogs
    for HIST1H2AK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2AK gene
    HIST1H2AL1 2  HIST1H2AM1 2  HIST1H2AI1 2  HIST1H2AG1 2  HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  
    H2AFX2  HIST1H2AC2  HIST1H2AH2  HIST1H2AJ2  HIST2H2AA42  HIST1H2AE2  HIST2H2AC2  HIST1H2AB2  
    H2AFJ2  
    18/26 SIMAP similar genes for HIST1H2AK using alignment to 2 protein entries:     H2A1_HUMAN (see all proteins) (see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH
    HIST1H2AI    HIST1H2AJ    HIST1H2AL    HIST1H2AM    HIST2H2AA3    HIST2H2AA4
    HIST3H2A    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX

    HIST1H2AK for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HIST1H2AK
    PGOHUM00000248361


    Genomic Variants
    for HIST1H2AK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/54 NCBI SNPs in HIST1H2AK are shown (see all 54)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs347068831,2
    		C,F,H,--27805255(+) CTCTTA/CAACTG 2 -- ds5001 us2k17Minor allele frequency- C:0.06NS NA 628
    rs1815210761,2
    		--27805273(+) CCAGAC/TCTTGC 2 -- us2k1 ds50010--------
    rs1501812431,2
    		--27805285(+) GGCCAC/GGAGGT 2 -- us2k1 ds50010--------
    rs728473491,2
    		C,F,--27805303(+) CACATT/CATCTC 2 -- ds5001 us2k11Minor allele frequency- C:0.06NA 120
    rs574753761,2
    		C,--27805344(+) TGTTAT/CCTCGC 2 -- ds5001 us2k12Minor allele frequency- C:0.04WA 120
    rs2006999431,2
    		--27805817(+) GGTCAC/GTTTAC 3 L V us2k1 mis10--------
    rs2000208241,2
    		--27805829(+) AAGCAC/GCTTGT 3 L V us2k1 mis10--------
    rs1418332761,2
    		C,F,--27805902(+) TTGTCG/CCGGGC 3 /R syn1 us2k12Minor allele frequency- C:0.00NA EU 5869
    rs1462105891,2
    		C,F--27805907(+) GCGGGC/TCGCGT 3 T A us2k1 mis11Minor allele frequency- T:0.00NA 4548
    rs1462509741,2
    		C,F,--27805938(+) TCGGCG/CGTTAG 3 /T syn1 us2k11Minor allele frequency- C:0.02NA 4520

    HapMap Linkage Disequilibrium report for HIST1H2AK (27805626 - 27806124 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H2AK: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H2AK
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2AK

    Disorders / Diseases
    for HIST1H2AK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H2AK for disorders           About GeneDecksing

    OMIM gene information: 602788    OMIM disorders: --

    4 diseases for HIST1H2AK:    About MalaCards
    riddle syndrome    systemic lupus erythematosus    lupus erythematosus    immunodeficiency


    Export disorders for HIST1H2AK gene to outside databases

    Publications
    for HIST1H2AK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2AK gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with HIST1H2AK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (1997)
    3. Characterization of histones H2A and H2B variants and their post- translational modifications by mass spectrometry. (PubMed id 16319397)1, 2 Bonenfant D.... van Oostrum J. (2006)
    4. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (2006)
    5. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)1, 2 Boyne M.T. II... Kelleher N.L. (2006)
    6. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (2005)
    7. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    8. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (2004)
    9. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (2004)
    10. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)1, 2 Aihara H.... Ito T. (2004)

    External Searches for HIST1H2AK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H2AK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8330 HGNC: 4726 AceView: HIST1H2AK Ensembl:ENSG00000184348 euGenes: HUgn8330
    ECgene: HIST1H2AK Kegg: 8330 H-InvDB: HIST1H2AK

    Other Databases showing HIST1H2AK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H2AK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2AK Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H2AK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H2AK gene:
    Search GeneIP for patents involving HIST1H2AK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HIST1H2AK gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H2AK
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HIST1H2AK  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H2AK   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H2AK  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HIST1H2AK   OriGene 3'-UTR Clone for HIST1H2AK  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2AK   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H2AK  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST1H2AK   OriGene Custom Protein Services for HIST1H2AK  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST1H2AK
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H2AK
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2AK
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H2AK
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AK
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AK
     GenScript Custom Purified and Recombinant Proteins Services for HIST1H2AK GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H2AK
     GenScript Custom Assay Services for HIST1H2AK GenScript Custom Superior Antibodies Services for HIST1H2AK
     GenScript Custom overexpressing Cell Line Services for HIST1H2AK CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HIST1H2AK promoter
     Search Chromatin IP Primers for HIST1H2AK
     RT2 qPCR Primer Assay in human, mouse, rat HIST1H2AK
     Search GNC Networks for HIST1H2AK
     SABiosciences Custom PCR Arrays for HIST1H2AK
     Search Tocris compounds for HIST1H2AK
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HIST1H2AK proteins
     Search for Antibodies for HIST1H2AK at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HIST1H2AK
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HIST1H2AK Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HIST1H2AK
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2AK
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H2AK
     SwitchGear Promoter luciferase reporter plasmids for HIST1H2AK
     ThermoFisher Antibody for HIST1H2AK
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2AK
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HIST1H2AK gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4