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Aliases for HIST1H2AK Gene

Aliases for HIST1H2AK Gene

  • Histone Cluster 1, H2ak 2 3 5
  • H2A Histone Family, Member D 2 3
  • Histone 1, H2ak 2 3
  • H2A.1 3 4
  • H2AFD 3 4
  • HIST1H2AG HIST1H2AI HIST1H2AK HIST1H2AL HIST1H2AM 4
  • Histone H2A Type 1-J 3
  • Histone H2A/P 4
  • H2AFP 4
  • H2AFC 4
  • H2AFI 4
  • H2AFN 4
  • H2A/D 3

External Ids for HIST1H2AK Gene

Previous HGNC Symbols for HIST1H2AK Gene

  • H2AFD

Previous GeneCards Identifiers for HIST1H2AK Gene

  • GC06M027863
  • GC06M027913
  • GC06M027807
  • GC06M027613
  • GC06M027844
  • GC06M027851

Summaries for HIST1H2AK Gene

Entrez Gene Summary for HIST1H2AK Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2AK Gene

HIST1H2AK (Histone Cluster 1, H2ak) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is H2AFB1.

UniProtKB/Swiss-Prot for HIST1H2AK Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2AK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AK Gene

Genomics for HIST1H2AK Gene

Regulatory Elements for HIST1H2AK Gene

Enhancers for HIST1H2AK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIST1H2AK on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H2AK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H2AK on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H2AK Gene

Chromosome:
6
Start:
27,837,880 bp from pter
End:
27,838,339 bp from pter
Size:
460 bases
Orientation:
Minus strand

Genomic View for HIST1H2AK Gene

Genes around HIST1H2AK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2AK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2AK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AK Gene

Proteins for HIST1H2AK Gene

  • Protein details for HIST1H2AK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0S8-H2A1_HUMAN
    Recommended name:
    Histone H2A type 1
    Protein Accession:
    P0C0S8
    Secondary Accessions:
    • P02261
    • Q2M1R2
    • Q76PA6

    Protein attributes for HIST1H2AK Gene

    Size:
    130 amino acids
    Molecular mass:
    14091 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2AK Gene

neXtProt entry for HIST1H2AK Gene

Proteomics data for HIST1H2AK Gene at MOPED

Post-translational modifications for HIST1H2AK Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys 14 and Lys 16
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AK Gene

Domains & Families for HIST1H2AK Gene

Gene Families for HIST1H2AK Gene

Protein Domains for HIST1H2AK Gene

Suggested Antigen Peptide Sequences for HIST1H2AK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C0S8

UniProtKB/Swiss-Prot:

H2A1_HUMAN :
  • Belongs to the histone H2A family.
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AK: view

Function for HIST1H2AK Gene

Molecular function for HIST1H2AK Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for HIST1H2AK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with HIST1H2AK: view
genes like me logo Genes that share phenotypes with HIST1H2AK: view

Animal Model Products

miRNA for HIST1H2AK Gene

miRTarBase miRNAs that target HIST1H2AK

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AK Gene

Localization for HIST1H2AK Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2AK Gene COMPARTMENTS Subcellular localization image for HIST1H2AK gene
Compartment Confidence
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HIST1H2AK Gene

Pathways & Interactions for HIST1H2AK Gene

genes like me logo Genes that share pathways with HIST1H2AK: view

Pathways by source for HIST1H2AK Gene

Gene Ontology (GO) - Biological Process for HIST1H2AK Gene

None

No data available for SIGNOR curated interactions for HIST1H2AK Gene

Drugs & Compounds for HIST1H2AK Gene

No Compound Related Data Available

Transcripts for HIST1H2AK Gene

mRNA/cDNA for HIST1H2AK Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AK Gene

Histone cluster 1, H2ak:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AK Gene

No ASD Table

Relevant External Links for HIST1H2AK Gene

GeneLoc Exon Structure for
HIST1H2AK
ECgene alternative splicing isoforms for
HIST1H2AK

Expression for HIST1H2AK Gene

mRNA expression in normal human tissues for HIST1H2AK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIST1H2AK Gene

This gene is overexpressed in Saliva (40.4) and Heart (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HIST1H2AK Gene



SOURCE GeneReport for Unigene cluster for HIST1H2AK Gene Hs.734717

genes like me logo Genes that share expression patterns with HIST1H2AK: view

Protein tissue co-expression partners for HIST1H2AK Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HIST1H2AK Gene

Orthologs for HIST1H2AK Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2AK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC541108 35
  • 85.38 (n)
  • 98.46 (a)
dog
(Canis familiaris)
Mammalia HIST2H2AA4 35
  • 85.9 (n)
  • 98.46 (a)
mouse
(Mus musculus)
Mammalia Hist1h2ac 35
  • 88.46 (n)
  • 98.46 (a)
Hist1h2ac 16
chimpanzee
(Pan troglodytes)
Mammalia LOC471909 35
  • 90 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Hist1h2af 35
  • 84.62 (n)
  • 96.15 (a)
Species with no ortholog for HIST1H2AK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AK Gene

ENSEMBL:
Gene Tree for HIST1H2AK (if available)
TreeFam:
Gene Tree for HIST1H2AK (if available)

Paralogs for HIST1H2AK Gene

Paralogs for HIST1H2AK Gene

genes like me logo Genes that share paralogs with HIST1H2AK: view

Variants for HIST1H2AK Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AK Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs5875148 -- 27,840,162(+) AAAAG(-/A/AA)AAAAA upstream-variant-2KB
rs4145464 -- 27,840,172(+) AAAAA(A/T)agagg upstream-variant-2KB
rs368679657 -- 27,840,212(+) CCCAC(C/T)CCCAA upstream-variant-2KB
rs145249658 -- 27,839,996(+) TTTTT(A/G)GAGGA upstream-variant-2KB
rs398110004 -- 27,840,171(+) AAAAA(-/A/AT)TAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AK Gene

Variant ID Type Subtype PubMed ID
nsv883512 CNV Gain 21882294

Variation tolerance for HIST1H2AK Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HIST1H2AK Gene

Disorders for HIST1H2AK Gene

Relevant External Links for HIST1H2AK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2AK

No disorders were found for HIST1H2AK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AK Gene

Publications for HIST1H2AK Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. (PMID: 25281266) Lubula M.Y. … Glass K.C. (FEBS Lett. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for HIST1H2AK Gene

Sources for HIST1H2AK Gene

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