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HIST1H2AK Gene

protein-coding   GIFtS: 52
GCID: GC06M027807

Histone Cluster 1, H2ak

(Previous names: H2A histone family, member D, histone 1, H2ak)
(Previous symbol: H2AFD)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H2ak1 2     Histone H2A Type 1-J2
H2AFD1 2 3 5     H2AFC3
H2A Histone Family, Member D1 2     H2AFI3
Histone 1, H2ak1 2     H2AFN3
H2A.12 3     H2AFP3
H2A/d2     Histone H2A/P3
Histone H2A Type 12     HIST1H2AI5

External Ids:    HGNC: 47261   Entrez Gene: 83302   Ensembl: ENSG000001843487   OMIM: 6027885   UniProtKB: P0C0S83   

Export aliases for HIST1H2AK gene to outside databases

Previous GC identifers: GC06M027863 GC06M027913 GC06M027613


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H2AK Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster
on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2AK Gene:
HIST1H2AK (histone cluster 1, H2ak) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2AK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H2AK gene promoter:
         AhR   AML1a   XBP-1   Arnt   E47   HEN1   CREB   FOXO4   deltaCREB   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2AK promoter sequence
   Search Chromatin IP Primers for HIST1H2AK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2AK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2AK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AK gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027807:  view genomic region     (about GC identifiers)

Start:
27,805,658 bp from pter      End:
27,806,117 bp from pter
Size:
460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8 (See protein sequence)
Recommended Name: Histone H2A type 1  
Size: 130 amino acids; 14091 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Mass spectrometry: Mass=13993.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: P02261 Q2M1R2 Q76PA6

Explore the universe of human proteins at neXtProt for HIST1H2AK: NX_P0C0S8

Explore proteomics data for HIST1H2AK at MOPED

Post-translational modifications: 

  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly
    represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at
    Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates
    their transcription1
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)1
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at
    35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus (H2AE)

  • See HIST1H2AK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003501.1  
    ENSEMBL proteins: 
     ENSP00000330307  
    Reactome Protein details: P0C0S8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P0C0S8

    ProtoNet protein and cluster: P0C0S8

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
    Similarity: Belongs to the histone H2A family


    Find genes that share domains with HIST1H2AK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A1_HUMAN, P0C0S8
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0019899enzyme binding ----
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with HIST1H2AK           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HIST1H2AK:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HIST1H2AK

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    miRTarBase miRNAs that target HIST1H2AK:
    hsa-mir-34a-5p (MIRT025446)

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    hsa-miR-146a* hsa-miR-659
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2A1_HUMAN, P0C0S8: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with HIST1H2AK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H2AK About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    Systemic lupus erythematosus0.40
    Chromatin organization0.34
    HATs acetylate histones0.34
    Alcoholism0.34
    Chromatin modifying enzymes0.34
    2Packaging Of Telomere Ends
    Signal transduction Activin A signaling regulation0.40
    Histone modification0.31


    Find genes that share SuperPaths with HIST1H2AK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2AK
        Signal transduction Activin A signaling regulation

    1 Reactome Pathway for HIST1H2AK
        HATs acetylate histones


    2 Kegg Pathways  (Kegg details for HIST1H2AK):
        Alcoholism
    Systemic lupus erythematosus

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H2AK
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H2AK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for HIST1H2AK (P0C0S81, 2, 3 ENSP000003303074) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL33O957601, 2, 3EBI-1390628,EBI-724057 MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    YWHAZP631041, 2, 3EBI-1390628,EBI-347088 MINT-3296701 MINT-7899812 I2D: score=1 
    RYBPQ8N4882, 3MINT-3973842 MINT-3973898 I2D: score=1 
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=1 STRING: ENSP00000238081
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    Find genes that share ontologies with HIST1H2AK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HIST1H2AK (H2A1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIST1H2AK gene: 
    NM_003510.2  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000330180(uc003njs.3)
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    15 AceView cDNA sequences:

    BG722363 H54606 BF061074 BP341166 AI366817 NM_003510 BX098128 BF439498 
    BI524579 BC034487 AI809266 BQ300928 AI424840 AI809131 H54717 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H2AK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H2AK Expression
    About this image


    HIST1H2AK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier
    HIST1H2AK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H2AK Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H2AK gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2ak5
    Hist1h2ac1
    histone cluster 1, H2ak5
    histone cluster 1, H2ac1
    88.46(n)1
    98.46(a)1
      13 (7.95 cM)5
    3191641  NM_178189.41  NP_835496.11 
     217534355 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Histone H2A
    99(a)
    99(a)
    many ↔ many
    many ↔ many
    GL343466.1(242198-242587)
    GL343220.1(86772-87161)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ616599.12   -- 78.8(n)    BJ616599.1 


    ENSEMBL Gene Tree for HIST1H2AK (if available)
    TreeFam Gene Tree for HIST1H2AK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H2AK gene
    HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  
    HIST1H2AH2  HIST1H2AM2  HIST1H2AJ2  HIST1H2AA2  HIST2H2AA42  HIST1H2AE2  HIST1H2AB2  HIST2H2AC2  
    HIST1H2AL2  H2AFJ2  
    Selected SIMAP similar genes for HIST1H2AK using alignment to 2 protein entries:     H2A1_HUMAN (see all proteins) (see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH
    HIST1H2AI    HIST1H2AJ    HIST1H2AL    HIST1H2AM    HIST2H2AA3    HIST2H2AA4
    HIST3H2A    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX

    Find genes that share paralogs with HIST1H2AK           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HIST1H2AK
    PGOHUM00000248361


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    10 SNPs for HIST1H2AK    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs784998801,2
    C--27807568(+) CCTCCC/TTTGTC 1 -- us2k12Minor allele frequency- T:0.10CSA WA 120
    rs1452496581,2
    --27807774(+) TTTTTA/GGAGGA 1 -- us2k10--------
    rs1491578031,2
    --27807889(+) CTTGTC/GTGTGT 1 -- us2k10--------
    rs2005718421,2
    ----27807939(+) TTAAAA/GGAAAA 1 -- us2k10--------
    rs2012733121,2
    ----27807940(+) TAAAAA/GAAAAA 1 -- us2k10--------
    rs3686796571,2
    ----27807990(+) CCCACC/TCCCAA 1 -- us2k10--------
    rs339371441,2
    ----27807950(+) AAAAT-/AAGAGG 1 -- us2k10--------
    rs41454641,2
    ----27807950(+) AAAAAA/Tagagg 1 -- us2k10--------
    rs3726795031,2
    ----27807942(+) AAGAA-/AAAAAA 1 -- us2k10--------
    rs3773844361,2
    ----27807948(+) AAAAA-/AATAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2AK (27805658 - 27806117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H2AK:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2AK
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2AK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602788    OMIM disorders: --


    Find genes that share disorders with HIST1H2AK           About GenesLikeMe


    Export disorders for HIST1H2AK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H2AK gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with HIST1H2AK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (Hum. Genet. 1997)
    3. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (Genes Dev. 2006)
    4. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)1, 2 Boyne M.T. II... Kelleher N.L. (J. Proteome Res. 2006)
    5. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (Biochemistry 2005)
    6. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (Mol. Cell 2005)
    7. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (Nature 2004)
    8. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (J. Biol. Chem. 2004)
    9. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)1, 2 Aihara H.... Ito T. (Genes Dev. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8330 HGNC: 4726 AceView: HIST1H2AK Ensembl:ENSG00000184348 euGenes: HUgn8330
    ECgene: HIST1H2AK Kegg: 8330 H-InvDB: HIST1H2AK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H2AK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H2AK gene:
    Search GeneIP for patents involving HIST1H2AK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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