Aliases for HIST1H2AJ Gene
Aliases for HIST1H2AJ Gene
External Ids for HIST1H2AJ Gene
- HGNC: 4727
- Entrez Gene: 8331
- Ensembl: ENSG00000276368
- OMIM: 602791
- UniProtKB: Q99878
Previous HGNC Symbols for HIST1H2AJ Gene
- H2AFE
Previous GeneCards Identifiers for HIST1H2AJ Gene
- GC06M027840
- GC06M027890
- GC06M027782
- GC06M027591
Summaries for HIST1H2AJ Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H2AJ Gene
HIST1H2AJ (Histone Cluster 1 H2A Family Member J) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Meiosis. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2AM.
UniProtKB/Swiss-Prot for HIST1H2AJ Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AJ Gene
Genomics for HIST1H2AJ Gene
Regulatory Elements for HIST1H2AJ Gene
Enhancers for HIST1H2AJ Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G027834 | 2.1 | FANTOM5 Ensembl ENCODE dbSUPER | 7.7 | -22.6 | -22553 | 6.4 | CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 MEF2D ZNF610 | ZKSCAN3 ZKSCAN4 ZKSCAN8 HIST1H3J HIST1H2BN HIST1H2AI HIST1H4J ZNF603P HIST1H2BM HIST1H2BO |
| GH06G027887 | 1.8 | FANTOM5 ENCODE dbSUPER | 4 | -78.7 | -78741 | 11.9 | CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 NFYC TBX21 SSRP1 ZNF610 | ZKSCAN3 ZKSCAN4 ZNF603P ZKSCAN8 ZSCAN9 HIST1H4K HIST1H3H HIST1H2BN HIST1H2BL HIST1H2AK |
| GH06G027805 | 2 | FANTOM5 Ensembl ENCODE dbSUPER | 3 | +2.6 | 2626 | 12.7 | CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 NFYC TBX21 MEF2D | ZNF603P ZKSCAN3 ZKSCAN4 ZNF192P1 HIST1H4K ZNF204P HIST1H2BN ZNF602P HIST1H2AI ENSG00000270326 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H2AJ on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIST1H2AJ Gene
- Chromosome:
- 6
- Start:
- 27,814,302 bp from pter
- End:
- 27,814,740 bp from pter
- Size:
- 439 bases
- Orientation:
- Minus strand
Genomic View for HIST1H2AJ Gene
Genes around HIST1H2AJ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by Ensembl
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC
HIST1H2AJ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H2AJ Gene
Proteins for HIST1H2AJ Gene
-
Protein details for HIST1H2AJ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99878-H2A1J_HUMAN
- Recommended name:
- Histone H2A type 1-J
- Protein Accession:
- Q99878
- A2RUU6
- Q5JXQ5
Protein attributes for HIST1H2AJ Gene
- Size:
- 128 amino acids
- Molecular mass:
- 13936 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST1H2AJ Gene
Post-translational modifications for HIST1H2AJ Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Deiminated on Arg-4 in granulocytes upon calcium entry.
- Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
- Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
- Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
- Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Ubiquitination at posLast=1414 and isoforms=16
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H2AJ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Cloud-Clone Corp. Antibodies for HIST1H2AJ
- Invitrogen Antibodies for HIST1H2AJ
- Invitrogen Antibodies for HIST1H2AJ
- antibodies-online Antibodies for HIST1H2AJ: See all 6
- Search GeneTex for Antibodies for HIST1H2AJ
Protein Products
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OriGene Purified Proteins for HIST1H2AJ
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-
Cloud-Clone Corp. Proteins for HIST1H2AJ
- antibodies-online Proteins for HIST1H2AJ: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HIST1H2AJ
Assay Products
No data available for DME Specific Peptides for HIST1H2AJ Gene
Domains & Families for HIST1H2AJ Gene
Gene Families for HIST1H2AJ Gene
- HGNC:
Protein Domains for HIST1H2AJ Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H2AJ Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99878- Family:
-
- Belongs to the histone H2A family.
Function for HIST1H2AJ Gene
Molecular function for HIST1H2AJ Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
| GO:0003677 | DNA binding | IBA | -- |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H2AJ Gene
- GenomeRNAi human phenotypes for HIST1H2AJ:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2AJ gene
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CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2AJ
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2AJ
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miRNA for HIST1H2AJ Gene
- miRTarBase miRNAs that target HIST1H2AJ
-
- hsa-mir-34a-5p (MIRT025519)
- hsa-mir-92b-5p (MIRT037794)
- hsa-mir-193b-3p (MIRT041250)
- hsa-mir-324-3p (MIRT042930)
- hsa-mir-16-5p (MIRT051259)
- hsa-mir-760 (MIRT360351)
- hsa-mir-6822-3p (MIRT360355)
- hsa-mir-5693 (MIRT511757)
- hsa-mir-8057 (MIRT511758)
- hsa-mir-573 (MIRT511759)
- hsa-mir-3616-5p (MIRT511760)
- hsa-mir-4795-5p (MIRT511761)
- hsa-mir-4766-5p (MIRT511762)
- hsa-mir-146a-3p (MIRT511763)
- hsa-mir-1276 (MIRT511764)
- hsa-mir-491-3p (MIRT523240)
miRNA Products
- Search ViGene Biosciences for HIST1H2AJ
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST1H2AJ
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HIST1H2AJ
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H2AJ gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2AJ gene
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AJ Gene
Localization for HIST1H2AJ Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AJ Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IBA | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | -- |
Pathways & Interactions for HIST1H2AJ Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.88
|
.34
|
| 2 | Cellular Senescence | ||
| 3 | Chromosome Maintenance | ||
| 4 | Cell Cycle, Mitotic |
.83
|
.60
|
| 5 | Chromatin organization | ||
Pathways by source for HIST1H2AJ Gene
58 Reactome pathways for HIST1H2AJ Gene
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Activation of anterior HOX genes in hindbrain development during early embryogenesis
- Activation of HOX genes during differentiation
- Amyloid fiber formation
- B-WICH complex positively regulates rRNA expression
2 KEGG pathways for HIST1H2AJ Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2AJ Gene
Interacting Proteins for HIST1H2AJ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006342 | chromatin silencing | IBA | -- |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for HIST1H2AJ Gene
Drugs & Compounds for HIST1H2AJ Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for HIST1H2AJ Gene
mRNA/cDNA for HIST1H2AJ Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (25) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H2AJ Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2AJ
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2AJ
- GenScript: Design CRISPR guide RNA sequences for HIST1H2AJ
miRNA Products
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Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIST1H2AJ
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Clone Products
-
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Flow Cytometry Products
Expression for HIST1H2AJ Gene
mRNA differential expression in normal tissues according to GTEx for HIST1H2AJ Gene
This gene is overexpressed in Whole Blood (x8.9), Small Intestine - Terminal Ileum (x5.0), Esophagus - Mucosa (x4.8), and Colon - Transverse (x4.3).
This gene is overexpressed in Saliva (40.4) and Heart (18.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIST1H2AJ Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H2AJ Gene:
HIST1H2AJSOURCE GeneReport for Unigene cluster for HIST1H2AJ Gene:
Hs.406691Primer Products
-
OriGene qPCR primer pairs for HIST1H2AJ
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2AJ Gene
Orthologs for HIST1H2AJ Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC737087 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HIST1H2AJ 34 |
|
||
| dog (Canis familiaris) |
Mammalia | LOC488304 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist1h2af 34 16 |
|
- Species where no ortholog for HIST1H2AJ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIST1H2AJ Gene
Paralogs for HIST1H2AJ Gene
(26) SIMAP similar genes for HIST1H2AJ Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HIST1H2AJ Gene
Variants for HIST1H2AJ Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1003588463 | -- | 27,813,983(+) | GTGTC(C/T)CAGTA | downstream-variant-500B, upstream-variant-2KB | |
| rs1004068522 | -- | 27,814,159(+) | AGTAT(C/G)TACAT | downstream-variant-500B, upstream-variant-2KB | |
| rs1004900989 | -- | 27,815,510(+) | AGCCA(A/G)TTCAC | downstream-variant-500B, upstream-variant-2KB | |
| rs1005229686 | -- | 27,814,266(+) | AAGCA(A/G)CTGAA | downstream-variant-500B, upstream-variant-2KB | |
| rs1005576257 | -- | 27,813,956(+) | TAAGA(A/G)GCTTT | downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3890803 | CNV | loss | 25118596 |
| nsv1017057 | CNV | gain | 25217958 |
| nsv830618 | CNV | gain | 17160897 |
| nsv970094 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
39.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.26% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H2AJ Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H2AJ
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AJ Gene
Disorders for HIST1H2AJ Gene
Relevant External Links for HIST1H2AJ
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H2AJ
No disorders were found for HIST1H2AJ Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AJ Gene
Publications for HIST1H2AJ Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4 64
- Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC. (PMID: 28137758) You H. … Liang X. (J. Cell. Sci. 2017) 3 64
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
- Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. (PMID: 24352239) Tessarz P. … Kouzarides T. (Nature 2014) 4 64
Products for HIST1H2AJ Gene
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- Mammalian expression: PiggyBac
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- Yeast expression
Sources for HIST1H2AJ Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
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- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer