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Aliases for HIST1H2AJ Gene

Aliases for HIST1H2AJ Gene

  • Histone Cluster 1, H2aj 2 3
  • H2AFE 3 4 6
  • H2A Histone Family, Member E 2 3
  • Histone 1, H2aj 2 3
  • Histone H2A/E 4
  • DJ160A22.4 3
  • HIST1H2AK 6
  • H2A/E 3

External Ids for HIST1H2AJ Gene

Previous HGNC Symbols for HIST1H2AJ Gene

  • H2AFE

Previous GeneCards Identifiers for HIST1H2AJ Gene

  • GC06M027840
  • GC06M027890
  • GC06M027782
  • GC06M027591

Summaries for HIST1H2AJ Gene

Entrez Gene Summary for HIST1H2AJ Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2AJ Gene

HIST1H2AJ (Histone Cluster 1, H2aj) is a Protein Coding gene. Diseases associated with HIST1H2AJ include hiv-1. Among its related pathways are Disease and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for HIST1H2AJ Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AJ Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AJ Gene

Genomics for HIST1H2AJ Gene

Regulatory Elements for HIST1H2AJ Gene

Genomic Location for HIST1H2AJ Gene

Start:
27,814,302 bp from pter
End:
27,814,740 bp from pter
Size:
439 bases
Orientation:
Minus strand

Genomic View for HIST1H2AJ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2AJ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AJ Gene

Proteins for HIST1H2AJ Gene

  • Protein details for HIST1H2AJ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99878-H2A1J_HUMAN
    Recommended name:
    Histone H2A type 1-J
    Protein Accession:
    Q99878
    Secondary Accessions:
    • A2RUU6
    • Q5JXQ5

    Protein attributes for HIST1H2AJ Gene

    Size:
    128 amino acids
    Molecular mass:
    13936 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

neXtProt entry for HIST1H2AJ Gene

Proteomics data for HIST1H2AJ Gene at MOPED

Post-translational modifications for HIST1H2AJ Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys14, Lys16, Lys96, Lys100, and Lys119
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AJ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AJ Gene

Domains for HIST1H2AJ Gene

Gene Families for HIST1H2AJ Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2AJ Gene

Suggested Antigen Peptide Sequences for HIST1H2AJ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99878

UniProtKB/Swiss-Prot:

H2A1J_HUMAN :
  • Q99878
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AJ: view

Function for HIST1H2AJ Gene

Molecular function for HIST1H2AJ Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2AJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function --
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding --
GO:0046982 protein heterodimerization activity --
genes like me logo Genes that share ontologies with HIST1H2AJ: view

miRNA for HIST1H2AJ Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2AJ

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2AJ Gene

Localization for HIST1H2AJ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AJ Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2AJ Gene COMPARTMENTS Subcellular localization image for HIST1H2AJ gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2AJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0070062 extracellular exosome --
genes like me logo Genes that share ontologies with HIST1H2AJ: view

Pathways for HIST1H2AJ Gene

genes like me logo Genes that share pathways with HIST1H2AJ: view

Pathways by source for HIST1H2AJ Gene

29 Reactome pathways for HIST1H2AJ Gene
2 KEGG pathways for HIST1H2AJ Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2AJ Gene

Gene Ontology (GO) - Biological Process for HIST1H2AJ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process --
genes like me logo Genes that share ontologies with HIST1H2AJ: view

Compounds for HIST1H2AJ Gene

(1) HMDB Compounds for HIST1H2AJ Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with HIST1H2AJ: view

Transcripts for HIST1H2AJ Gene

mRNA/cDNA for HIST1H2AJ Gene

(25) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AJ Gene

Histone cluster 1, H2aj:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2AJ

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST1H2AJ
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AJ Gene

No ASD Table

Relevant External Links for HIST1H2AJ Gene

GeneLoc Exon Structure for
HIST1H2AJ
ECgene alternative splicing isoforms for
HIST1H2AJ

Expression for HIST1H2AJ Gene

mRNA expression in normal human tissues for HIST1H2AJ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H2AJ Gene

This gene is overexpressed in Whole Blood (8.9), Small Intestine - Terminal Ileum (5.0), Esophagus - Mucosa (4.8), and Colon - Transverse (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HIST1H2AJ Gene

SOURCE GeneReport for Unigene cluster for HIST1H2AJ Gene Hs.406691

genes like me logo Genes that share expressions with HIST1H2AJ: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H2AJ Gene

Orthologs for HIST1H2AJ Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2AJ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC737087 35
  • 99.48 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HIST1H2AJ 35
  • 90.36 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia LOC488304 35
  • 89.64 (n)
  • 97.48 (a)
mouse
(Mus musculus)
Mammalia Hist1h2af 35
  • 88.28 (n)
  • 97.66 (a)
Hist1h2aj 16
Species with no ortholog for HIST1H2AJ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AJ Gene

ENSEMBL:
Gene Tree for HIST1H2AJ (if available)
TreeFam:
Gene Tree for HIST1H2AJ (if available)

Paralogs for HIST1H2AJ Gene

genes like me logo Genes that share paralogs with HIST1H2AJ: view

No data available for Paralogs for HIST1H2AJ Gene

Variants for HIST1H2AJ Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AJ Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs9295750 -- 27,816,650(+) TTCCA(A/G)TTTAG upstream-variant-2KB
rs34718920 -- 27,816,163(+) CTGGC(C/T)AACGT upstream-variant-2KB
rs75560724 -- 27,816,530(+) AGGAT(G/T)CAAAA upstream-variant-2KB
rs114109363 -- 27,816,302(+) AACCG(A/G)GTCGT upstream-variant-2KB
rs138810951 -- 27,816,278(+) ACCCG(G/T)GAGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AJ Gene

Variant ID Type Subtype PubMed ID
nsv830618 CNV Gain 17160897
nsv883512 CNV Gain 21882294

Relevant External Links for HIST1H2AJ Gene

HapMap Linkage Disequilibrium report
HIST1H2AJ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AJ Gene

Disorders for HIST1H2AJ Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HIST1H2AJ Gene including...

Search for HIST1H2AJ Gene in MalaCards »
genes like me logo Genes that share disorders with HIST1H2AJ: view

No data available for UniProtKB/Swiss-Prot for HIST1H2AJ Gene

Publications for HIST1H2AJ Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4
  3. Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter. (PMID: 9566873) El Kharroubi A. … Martin M.A. (Mol. Cell. Biol. 1998) 3
  4. The human H2A and H2B histone gene complement. (PMID: 10064132) Albig W. … Doenecke D. (Biol. Chem. 1999) 3
  5. Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones. (PMID: 11080476) Deng L. … Kashanchi F. (Virology 2000) 3

Products for HIST1H2AJ Gene

Sources for HIST1H2AJ Gene

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