Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIST1H2AJ Gene

protein-coding   GIFtS: 52
GCID: GC06M027782

Histone Cluster 1, H2aj

(Previous names: H2A histone family, member E, histone 1, H2aj)
(Previous symbol: H2AFE)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Histone Cluster 1, H2aj1 2     H2A/E2
H2AFE1 2 3 5     dJ160A22.42
H2A Histone Family, Member E1 2     Histone H2A/E3
Histone 1, H2aj1 2     HIST1H2AK5

External Ids:    HGNC: 47271   Entrez Gene: 83312   Ensembl: ENSG000001826117   OMIM: 6027915   UniProtKB: Q998783   

Export aliases for HIST1H2AJ gene to outside databases

Previous GC identifers: GC06M027840 GC06M027890 GC06M027591


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HIST1H2AJ Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster
on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2AJ Gene:
HIST1H2AJ (histone cluster 1, H2aj) is a protein-coding gene. Diseases associated with HIST1H2AJ include riddle syndrome, and systemic lupus erythematosus. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A1J_HUMAN, Q99878
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2AJ Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H2AJ gene promoter:
         NF-YA   AP-4   CUTL1   Egr-4   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2AJ promoter sequence
   Search Chromatin IP Primers for HIST1H2AJ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2AJ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2AJ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AJ gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027782:  view genomic region     (about GC identifiers)

Start:
27,782,080 bp from pter      End:
27,782,607 bp from pter
Size:
528 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: H2A1J_HUMAN, Q99878 (See protein sequence)
Recommended Name: Histone H2A type 1-J  
Size: 128 amino acids; 13936 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Mass spectrometry: Mass=13838.7; Method=Electrospray; Range=2-128; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: A2RUU6 Q5JXQ5

Explore the universe of human proteins at neXtProt for HIST1H2AJ: NX_Q99878

Explore proteomics data for HIST1H2AJ at MOPED

Post-translational modifications: 

  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly
    represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at
    Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates
    their transcription1
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at
    35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239)1
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys14, Lys16, Lys96, Lys100, Lys119
  • Modification sites at PhosphoSitePlus

  • See HIST1H2AJ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066544.1  
    ENSEMBL proteins: 
     ENSP00000328484  
    Reactome Protein details: Q99878

    HIST1H2AJ Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HIST1H2AJ
    OriGene Protein Over-expression Lysate for HIST1H2AJ
    OriGene MassSpec for HIST1H2AJ
    OriGene Custom Protein Services for HIST1H2AJ
    GenScript Custom Purified and Recombinant Proteins Services for HIST1H2AJ
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H2AJ

    HIST1H2AJ Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIST1H2AJ
    Abcam antibodies for HIST1H2AJ
    Cloud-Clone Corp. Antibodies for HIST1H2AJ
    Search ThermoFisher Antibodies for HIST1H2AJ
    Search LSBio for Antibodies for HIST1H2AJ

    HIST1H2AJ Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIST1H2AJ
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIST1H2AJ
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIST1H2AJ
    Cloud-Clone Corp. CLIAs for HIST1H2AJ


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry Q99878

    ProtoNet protein and cluster: Q99878

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1J_HUMAN, Q99878
    Similarity: Belongs to the histone H2A family


    HIST1H2AJ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A1J_HUMAN, Q99878
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H2AJ for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H2AJ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST1H2AJ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H2AJ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H2AJ

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST1H2AJ:
    hsa-mir-16-5p (MIRT051259), hsa-mir-324-3p (MIRT042930), hsa-mir-193b-3p (MIRT041250), hsa-mir-92b-5p (MIRT037794), hsa-mir-34a-5p (MIRT025519)

    Block miRNA regulation of human, mouse, rat HIST1H2AJ using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST1H2AJ:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIST1H2AJ
    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2AJ

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIST1H2AJ

    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H2AJ (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H2AJ (NM_021066)
    Sino Biological Human cDNA Clone for HIST1H2AJ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2AJ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2AJ

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIST1H2AJ
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIST1H2AJ 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AJ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    H2A1J_HUMAN, Q99878: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005622intracellular ----
    GO:0005634nucleus ----

    HIST1H2AJ for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HIST1H2AJ About   (see all 7)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Nucleosome assembly0.59
    Meiotic Synapsis0.66
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Signal transduction Activin A signaling regulation0.40
    Telomere Maintenance0.64
    Histone modification0.31
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2AJ
        Signal transduction Activin A signaling regulation


    Selected Reactome Pathways for HIST1H2AJ (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    2 Kegg Pathways  (Kegg details for HIST1H2AJ):
        Alcoholism
    Systemic lupus erythematosus


    HIST1H2AJ for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H2AJ
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H2AJ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H2AJ (Q998783 ENSP000003284844) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTMAP064543, ENSP000003445474I2D: score=1 STRING: ENSP00000344547
    UBCENSP000003448184STRING: ENSP00000344818
    KNCNENSP000003796074STRING: ENSP00000379607
    SUMO2ENSP000004059654STRING: ENSP00000405965
    CFDP1ENSP000002838824STRING: ENSP00000283882
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----

    HIST1H2AJ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H2AJ (H2A1J)

    1 HMDB Compound for HIST1H2AJ    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIST1H2AJ gene: 
    NM_021066.2  

    Unigene Cluster for HIST1H2AJ:

    Histone cluster 1, H2aj
    Hs.406691  [show with all ESTs]
    Unigene Representative Sequence: EL736764
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000333151(uc003njn.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIST1H2AJ using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST1H2AJ:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIST1H2AJ
    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2AJ
    Clone
    Products:
         
    OriGene clones in human, mouse for HIST1H2AJ (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIST1H2AJ (NM_021066)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H2AJ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2AJ
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2AJ
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HIST1H2AJ
      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AJ
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AJ

    Additional mRNA sequence: 

    BC066232.1 BC066233.1 BC066234.1 BC066235.1 BC066236.1 BC066237.1 BC133048.1 BC133050.1 

    1 DOTS entry:

    DT.97818883 

    Selected AceView cDNA sequences (see all 25):

    BC066237 NM_021066 BC066236 BC066233 CF272102 BC066235 BC066232 BC066234 
    CF272098 BQ186074 CF272096 CK299229 CF272090 CF272100 CF272104 CF272105 
    CF272094 CF272092 CF272099 CF272103 CF272101 CF272093 CF272095 CF272091 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIST1H2AJ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H2AJ Expression
    About this image


    HIST1H2AJ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    HIST1H2AJ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H2AJ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406691
        Custom PCR Arrays for HIST1H2AJ
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2AJ
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HIST1H2AJ
    QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AJ
    QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AJ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AJ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H2AJ gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2aj5
    Hist1h2af1
    histone cluster 1, H2aj5
    histone cluster 1, H2af1
    88.28(n)1
    97.66(a)1
      13 (7.94 cM)5
    3191731  NM_175661.11  NP_783592.11 
     217214575 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Histone H2A
    97(a)
    97(a)
    many ↔ many
    many ↔ many
    GL343220.1(86772-87161)
    GL343466.1(242198-242587)
    zebrafish
    (Danio rerio)
    Actinopterygii BI867824.12   -- 80.57(n)    BI867824.1 


    ENSEMBL Gene Tree for HIST1H2AJ (if available)
    TreeFam Gene Tree for HIST1H2AJ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIST1H2AJ gene
    HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  
    HIST1H2AH2  HIST1H2AM2  HIST1H2AA2  HIST2H2AA42  HIST1H2AE2  HIST1H2AB2  HIST2H2AC2  HIST1H2AK2  
    HIST1H2AL2  H2AFJ2  
    Selected SIMAP similar genes for HIST1H2AJ using alignment to 1 protein entry:     H2A1J_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH
    HIST1H2AI    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST2H2AA3    HIST2H2AA4
    HIST3H2A    H2AFJ    HIST1H2AA    HIST2H2AC    H2AFX    HIST2H2AB

    HIST1H2AJ for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HIST1H2AJ (see all 14)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815957091,2
    --27783838(+) TATGTA/GGAGGG 1 -- us2k10--------
    rs347189201,2
    C,F--27783941(+) CTGGCT/CAACGT 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1459866411,2
    --27784031(+) AGGCTA/GAGGCA 1 -- us2k10--------
    rs1862610321,2
    --27784052(+) TTGAAC/TCCGGG 1 -- us2k10--------
    rs1388109511,2
    --27784056(+) ACCCGG/TGAGGC 1 -- us2k10--------
    rs1141093631,2
    F--27784080(+) AACCGA/GGTCGT 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs1885827201,2
    --27784092(+) ATCGCA/GCCACT 1 -- us2k10--------
    rs1811572611,2
    --27784274(+) TTTTTA/TAAATT 1 -- us2k10--------
    rs755607241,2
    F--27784308(+) AGGATT/GCAAAA 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1412550541,2
    C--27784375(+) GAAACC/TCAACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2AJ (27782080 - 27782607 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H2AJ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830618CNV Gain17160897
    nsv883512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2AJ
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2AJ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602791    OMIM disorders: --

    8 diseases for HIST1H2AJ:    
    About MalaCards
    riddle syndrome    systemic lupus erythematosus    hiv-1    tonsillitis
    lupus erythematosus    cerebritis    thyroiditis    endotheliitis


    HIST1H2AJ for disorders           About GeneDecksing


    Export disorders for HIST1H2AJ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIST1H2AJ gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with HIST1H2AJ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (Hum. Genet. 1997)
    3. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. (PubMed id 24352239)2 Tessarz P.... Kouzarides T. (Nature 2014)
    4. VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. (PubMed id 24140421)2 Kim K.... An W. (Mol. Cell 2013)
    5. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (Cell Cycle 2012)
    6. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (Cell 2012)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8331 HGNC: 4727 AceView: HIST1H2AJ Ensembl:ENSG00000182611 euGenes: HUgn8331
    ECgene: HIST1H2AJ Kegg: 8331 H-InvDB: HIST1H2AJ

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIST1H2AJ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIST1H2AJ gene:
    Search GeneIP for patents involving HIST1H2AJ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HIST1H2AJ  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HIST1H2AJ  
     OriGene MassSpec something-or-other for HIST1H2AJ   OriGene clones in human, mouse for HIST1H2AJ  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H2AJ   OriGene Purified Protein for HIST1H2AJ  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIST1H2AJ   OriGene Custom Protein Services for HIST1H2AJ  

     
     
     Block miRNA regulation of human, mouse, rat HIST1H2AJ using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIST1H2AJ
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2AJ Predesigned siRNA for gene silencing in human, mouse, rat HIST1H2AJ
     QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AJ QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AJ
     Custom PCR Arrays for HIST1H2AJ Search Chromatin IP Primers for HIST1H2AJ
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HIST1H2AJ  Search GeneGlobe Interaction Network for HIST1H2AJ
     Regulatory tfbs in HIST1H2AJ promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIST1H2AJ GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H2AJ
     GenScript Custom Assay Services for HIST1H2AJ GenScript Custom overexpressing Cell Line Services for HIST1H2AJ
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HIST1H2AJ (H2A1J)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for HIST1H2AJ
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for HIST1H2AJ
     See all of Abcam's Antibodies, Kits and Proteins for HIST1H2AJ
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HIST1H2AJ
     Antibodies for HIST1H2AJ
     ELISAs for HIST1H2AJ
     CLIAs for HIST1H2AJ



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIST1H2AJ
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AJ
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H2AJ
     SwitchGear Promoter luciferase reporter plasmids for HIST1H2AJ
     Search ThermoFisher Antibodies for HIST1H2AJ
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H2AJ
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H2AJ
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIST1H2AJ
     Search LSBio for Antibodies for HIST1H2AJ
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIST1H2AJ gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4