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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2AI Gene

protein-coding   GIFtS: 48
GCID: GC06P027776

histone cluster 1, H2ai

(Previous names: H2A histone family, member C, histone 1, H2ai )
(Previous symbol: H2AFC)
 Explore 6 diseases affiliated with
HIST1H2AI via our new
 Human Malady Compendium 
Biological research products
for HIST1H2AI
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Histone Cluster 1, H2ai1 2     Histone H2A Type 12
H2AFC1 2 3 5     H2AFD3
H2A/C1     H2AFI3
H2A Histone Family, Member C1 2     H2AFN3
Histone 1, H2ai1 2     H2AFP3
H2A.12 3     Histone H2A/P3

External Ids:    HGNC: 47251   Entrez Gene: 83292   Ensembl: ENSG000001967477   OMIM: 6027875   UniProtKB: P0C0S83   

Export aliases for HIST1H2AI gene to outside databases

Previous GC identifers: GC06P027834 GC06P027883 GC06P027584


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2AI:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with
linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is
intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead
contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome
6p22-p21.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AI


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2AI gene promoter:
         NF-YA   AP-4   Egr-4   NF-YB   CBF-A   CBF-B   FOXO4   CP1A   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIST1H2AI

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2AI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2AI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AI gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027776:  view genomic region     (about GC identifiers)

Start:
27,775,899 bp from pter      End:
27,776,445 bp from pter
Size:
547 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8 (See protein sequence)
Recommended Name: Histone H2A type 1  
Size: 130 amino acids; 14091 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=13993.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: P02261 Q2M1R2 Q76PA6

Explore the universe of human proteins at neXtProt for HIST1H2AI: NX_P0C0S8

Post-translational modifications:

  • The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
  • transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by
    RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks
    (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases
    RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and
    Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates
    monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able
    to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked
    ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
  • transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
  • similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
  • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P0C0S8

  • HIST1H2AI Protein expression data from MOPED and PaxDb:    About this image 
    HIST1H2AI Protein Expression
    REFSEQ proteins: NP_003500.1  
    ENSEMBL proteins: 
     ENSP00000351589  

    Human Recombinant Protein Products for HIST1H2AI: 
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    Uscn Proteins for HIST1H2AI

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005634nucleus ----

    HIST1H2AI for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HIST1H2AI for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P0C0S8

    ProtoNet protein and cluster: P0C0S8

    1 Blocks protein family: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
    Similarity: Belongs to the histone H2A family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A1_HUMAN, P0C0S8
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0019899enzyme binding ----
         
    HIST1H2AI for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HIST1H2AI 

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    In Situ Assay
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    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H2AI


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation1.00
    Histone modification0.31
    Signal transduction_Activin A signaling regulation0.96
    2Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation1.00
    3Systemic lupus erythematosus
    Systemic lupus erythematosus1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2AI
        Histone modification
    Signal transduction Activin A signaling regulation


    1 Cell Signaling Technology (CST) Pathway for HIST1H2AI
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for HIST1H2AI
        Signal transduction Activin A signaling regulation


    1         Kegg Pathway  (Kegg details for HIST1H2AI):
        Systemic lupus erythematosus


    HIST1H2AI for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2AI

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/85 Interacting proteins for HIST1H2AI (P0C0S82, 3 ENSP000003515894) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL33O957602, 3MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    RYBPQ8N4882, 3MINT-3973842 MINT-3973898 I2D: score=1 
    YWHAZP631042, 3MINT-3296701 MINT-7899812 I2D: score=1 
    YWHAQP273482, 3MINT-7899812 I2D: score=1 
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----

    HIST1H2AI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2AI
    Search CenterWatch for drugs/clinical trials and news about HIST1H2AI / H2A1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H2AI gene: 
    NM_003509.2  

    Unigene Cluster for HIST1H2AI:

    Histone cluster 1, H2ai
    Hs.534035  [show with all ESTs]
    Unigene Representative Sequence: CK000930
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000358739

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    Additional cDNA sequence: 

    AK311766.1 BC112254.1 BC112256.1 

    1 DOTS entry:

    DT.436317 

    1 AceView cDNA sequence:

    BU659003 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2AI expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGGGCGTG
    HIST1H2AI Expression
    About this image
    See HIST1H2AI Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2AI

    SOURCE GeneReport for Unigene cluster: Hs.534035
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2AI gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    HIST1H2AA6
    --
    83(a)
    60(a)
    possible ortholog
    possible ortholog
    GL343252.1(1819594-1819782)
    GL344481.1(11179-11601)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.3492 Transcribed sequence with strong similarity to protein more 81.09(n)    137736131 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1956336
    FP236812.16
    (see all 31)
    --
    95(a)
    95(a)
    (see all 31)
    possible ortholog
    possible ortholog
    (see all 31)
    7(6748075-6748866)
    7(76847640-76848026)
    fruit fly
    (Drosophila melanogaster)
    Insecta His2A:CG338086
    His2A:CG338326
    (see all 20)
    His2A:CG33832
    (see all 20)
    88(a)
    88(a)
    (see all 20)
    possible ortholog
    possible ortholog
    (see all 20)
    2L(21433862-21434430)
    2L(21483244-21483812)
    rice
    (Oryza sativa)
    Liliopsida CB964727.12   -- 83.56(n)    CB964727.1 


    ENSEMBL Gene Tree for HIST1H2AI (if available)
    TreeFam Gene Tree for HIST1H2AI (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2AI gene
    HIST1H2AG1 2  HIST1H2AL1 2  HIST1H2AK1 2  HIST1H2AM1 2  HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  
    H2AFX2  HIST1H2AC2  HIST1H2AH2  HIST1H2AJ2  HIST2H2AA42  HIST1H2AE2  HIST2H2AC2  HIST1H2AB2  
    H2AFJ2  
    18/23 SIMAP similar genes for HIST1H2AI using alignment to 1 protein entry:     H2A1_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AH    HIST1H2AJ
    HIST1H2AK    HIST2H2AA3    HIST2H2AA4    HIST3H2A    H2AFJ    HIST1H2AA
    HIST2H2AB    HIST2H2AC    H2AFX    HIST1H2APS4    H2AFZ    H2AFB2

    HIST1H2AI for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/58 NCBI SNPs in HIST1H2AI are shown (see all 58    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1412654101,2
    --27774430(+) CCACTA/TTTTTT 1 -- us2k10--------
    rs2002073101,2
    --27774437(+) TTTTT-/TCTGAGA 1 -- us2k10--------
    rs2011624161,2
    C--27774437(+) TTTTTC/TTGAGA 1 -- us2k10--------
    rs77515761,2
    C,F,H--27774741(+) TAGTCG/CGAAAG 1 -- us2k1 tfbs36Minor allele frequency- C:0.01NS EA WA 540
    rs1808745521,2
    --27774775(+) CCTAGC/TGCTGT 2 -- ds5001 us2k10--------
    rs117576851,2
    C,H--27774813(+) CGTGCC/TTTAAA 2 -- ds5001 us2k14Minor allele frequency- T:0.00NS EA 420
    rs2004831,2
    C,F,O,H--27774824(+) ATCATG/ATCTGG 2 -- us2k1 ds500122Minor allele frequency- A:0.12NS EA NA WA CSA 2660
    rs177511841,2
    C,F,H--27775028(+) TTACAC/TGGAAC 2 -- us2k1 ds50019Minor allele frequency- T:0.05NA NS EA 684
    rs1507597691,2
    --27775080(+) GCCCTC/GAAGCG 2 -- us2k1 ds50010--------
    rs1391057721,2
    --27775130(+) CGTACC/TTCATG 2 -- us2k1 ds50010--------

    HapMap Linkage Disequilibrium report for HIST1H2AI (27775899 - 27776445 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H2AI: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HIST1H2AI for disorders           About GeneDecksing

    OMIM gene information: 602787    OMIM disorders: --

    6 diseases for HIST1H2AI:    About MalaCards
    riddle syndrome    systemic lupus erythematosus    lupus erythematosus    fanconi's anemia
    anemia    immunodeficiency


    Export disorders for HIST1H2AI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2AI gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with HIST1H2AI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (1997)
    3. The human H2A and H2B histone gene complement. (PubMed id 10064132)1, 2 Albig W.... Doenecke D. (1999)
    4. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (2012)
    5. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
    8. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    9. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8329 HGNC: 4725 AceView: HIST1H2AIandHIST1H3H Ensembl:ENSG00000196747 euGenes: HUgn8329
    ECgene: HIST1H2AI Kegg: 8329 H-InvDB: HIST1H2AI

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2AI Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H2AI gene:
    Search GeneIP for patents involving HIST1H2AI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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