Aliases for HIST1H2AI Gene
Aliases for HIST1H2AI Gene
External Ids for HIST1H2AI Gene
- HGNC: 4725
- Entrez Gene: 8329
- Ensembl: ENSG00000196747
- OMIM: 602787
- UniProtKB: P0C0S8
Previous HGNC Symbols for HIST1H2AI Gene
- H2AFC
Previous GeneCards Identifiers for HIST1H2AI Gene
- GC06P027834
- GC06P027883
- GC06P027776
- GC06P027584
- GC06P027780
Summaries for HIST1H2AI Gene
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H2AI Gene
HIST1H2AI (Histone Cluster 1 H2A Family Member I) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Deubiquitination. GO annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is HIST1H2AK.
UniProtKB/Swiss-Prot for HIST1H2AI Gene
-
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AI Gene
Genomics for HIST1H2AI Gene
Regulatory Elements for HIST1H2AI Gene
Regulatory Element Products
Genomic Location for HIST1H2AI Gene
- Chromosome:
- 6
- Start:
- 27,808,199 bp from pter
- End:
- 27,808,701 bp from pter
- Size:
- 503 bases
- Orientation:
- Plus strand
Genomic View for HIST1H2AI Gene
- Cytogenetic band:
-
- 6p22.1 by Ensembl
- 6p22.1 by Entrez Gene
- 6p22.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H2AI Gene
Proteins for HIST1H2AI Gene
-
Protein details for HIST1H2AI Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0C0S8-H2A1_HUMAN
- Recommended name:
- Histone H2A type 1
- Protein Accession:
- P0C0S8
- P02261
- Q2M1R2
- Q76PA6
Protein attributes for HIST1H2AI Gene
- Size:
- 130 amino acids
- Molecular mass:
- 14091 Da
- Quaternary structure:
-
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
- The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Protein Expression for HIST1H2AI Gene
Post-translational modifications for HIST1H2AI Gene
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- Deiminated on Arg-4 in granulocytes upon calcium entry.
- Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
- Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
- Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
- Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
- Ubiquitination at posLast=1414 and posLast=1616
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H2AI Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H2AI
- Cell Signaling Technology (CST) Antibodies for HIST1H2AI (H2A.1)
-
Cloud-Clone Corp. Antibodies for HIST1H2AI
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Protein Products
-
OriGene Purified Proteins for HIST1H2AI
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-
Cloud-Clone Corp. Proteins for HIST1H2AI
- GeneTex Proteins for HIST1H2AI
Assay Products
No data available for DME Specific Peptides for HIST1H2AI Gene
Domains & Families for HIST1H2AI Gene
Gene Families for HIST1H2AI Gene
- HGNC:
Protein Domains for HIST1H2AI Gene
- InterPro:
- Blocks:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
P0C0S8- Family:
-
- Belongs to the histone H2A family.
No data available for Suggested Antigen Peptide Sequences for HIST1H2AI Gene
Function for HIST1H2AI Gene
Molecular function for HIST1H2AI Gene
- UniProtKB/Swiss-Prot Function:
- Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 15161933 |
| GO:0019899 | enzyme binding | IPI | 17980597 |
| GO:0046982 | protein heterodimerization activity | IEA | -- |
Phenotypes for HIST1H2AI Gene
- GenomeRNAi human phenotypes for HIST1H2AI:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H2AI gene
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CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2AI
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2AI
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miRNA for HIST1H2AI Gene
- miRTarBase miRNAs that target HIST1H2AI
-
- hsa-mir-34a-5p (MIRT025537)
- hsa-mir-760 (MIRT036736)
- hsa-mir-149-5p (MIRT045531)
- hsa-mir-218-1-3p (MIRT100124)
- hsa-mir-9-5p (MIRT100125)
- hsa-mir-146a-3p (MIRT100126)
- hsa-mir-450a-1-3p (MIRT100127)
- hsa-mir-659-3p (MIRT100128)
- hsa-mir-769-3p (MIRT100129)
- hsa-mir-450b-3p (MIRT100130)
- hsa-mir-887-5p (MIRT100131)
- hsa-mir-1276 (MIRT100132)
- hsa-mir-3122 (MIRT100134)
- hsa-mir-3913-5p (MIRT100137)
- hsa-mir-5089-5p (MIRT100138)
- hsa-mir-6513-5p (MIRT100139)
- hsa-mir-6728-5p (MIRT100140)
- hsa-mir-8057 (MIRT100142)
- hsa-mir-5693 (MIRT523241)
- hsa-mir-135b-3p (MIRT523242)
- hsa-mir-6802-5p (MIRT523243)
- hsa-mir-6822-3p (MIRT523244)
- hsa-mir-571 (MIRT523245)
- hsa-mir-219a-1-3p (MIRT523246)
- hsa-mir-4766-5p (MIRT523247)
- hsa-mir-3121-5p (MIRT523248)
- hsa-mir-6865-5p (MIRT523249)
- hsa-mir-6815-5p (MIRT523250)
miRNA Products
- Search ViGene Biosciences for HIST1H2AI
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H2AI
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HIST1H2AI
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H2AI gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AI Gene
Localization for HIST1H2AI Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AI Gene
- Nucleus. Chromosome.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000790 | nuclear chromatin | IBA | -- |
| GO:0005634 | nucleus | IDA | 16319397 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 20458337 |
Pathways & Interactions for HIST1H2AI Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.34
|
|
| 2 | Chromatin organization | ||
| 3 | Deubiquitination |
.74
|
|
| 4 | Metabolism of proteins | ||
| 5 | Chromatin Regulation / Acetylation | ||
Pathways by source for HIST1H2AI Gene
1 Cell Signaling Technology pathway for HIST1H2AI Gene
11 Reactome pathways for HIST1H2AI Gene
2 KEGG pathways for HIST1H2AI Gene
1 GeneGo (Thomson Reuters) pathway for HIST1H2AI Gene
Interacting Proteins for HIST1H2AI Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006342 | chromatin silencing | IBA | -- |
| GO:0008150 | biological_process | ND | -- |
No data available for SIGNOR curated interactions for HIST1H2AI Gene
Transcripts for HIST1H2AI Gene
mRNA/cDNA for HIST1H2AI Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H2AI Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H2AI
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H2AI
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miRNA Products
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Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H2AI
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Clone Products
-
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Flow Cytometry Products
Expression for HIST1H2AI Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HIST1H2AI Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H2AI Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H2AI Gene:
HIST1H2AISOURCE GeneReport for Unigene cluster for HIST1H2AI Gene:
Hs.534035Evidence on tissue expression from TISSUES for HIST1H2AI Gene
- Intestine(4.2)
- Spleen(4)
Primer Products
-
OriGene qPCR primer pairs for HIST1H2AI
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2AI Gene
Orthologs for HIST1H2AI Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HIST1H2AG 35 |
|
OneToMany | |
| LOC617905 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | -- 35 |
|
ManyToMany | |
| LOC471895 34 |
|
||||
| mouse (Mus musculus) |
Mammalia | Hist1h2an 35 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIST1H2AI 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.349 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100006331 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | His4:CG33893 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | his-31 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os10g0539500 34 |
|
- Species where no ortholog for HIST1H2AI was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIST1H2AI Gene
(23) SIMAP similar genes for HIST1H2AI Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HIST1H2AI Gene
Variants for HIST1H2AI Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1002165695 | -- | 27,806,319(+) | TGTAA(A/G)GATAG | upstream-variant-2KB | |
| rs1003461925 | -- | 27,808,757(+) | TCAGT(C/T)TTCGG | downstream-variant-500B, upstream-variant-2KB | |
| rs1005508169 | -- | 27,808,238(+) | AGGCA(A/G)AGCTC | upstream-variant-2KB, reference, missense | |
| rs1005703886 | -- | 27,807,472(+) | TTTAG(A/G)TAATA | downstream-variant-500B, upstream-variant-2KB | |
| rs1006594923 | -- | 27,808,065(+) | CTGCA(C/T)AATCG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3890803 | CNV | loss | 25118596 |
| nsv1017057 | CNV | gain | 25217958 |
| nsv830618 | CNV | gain | 17160897 |
| nsv969366 | CNV | duplication | 23825009 |
Relevant External Links for HIST1H2AI Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H2AI
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AI Gene
Disorders for HIST1H2AI Gene
Relevant External Links for HIST1H2AI
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIST1H2AI
No disorders were found for HIST1H2AI Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AI Gene
Publications for HIST1H2AI Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4 64
- Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne M.T. II … Kelleher N.L. (J. Proteome Res. 2006) 3 4 64
- The human H2A and H2B histone gene complement. (PMID: 10064132) Albig W. … Doenecke D. (Biol. Chem. 1999) 3 4 64
- Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64
Products for HIST1H2AI Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H2AI Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
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