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Aliases for HIST1H2AG Gene

Aliases for HIST1H2AG Gene

  • Histone Cluster 1, H2ag 2 3 5
  • H2A Histone Family, Member P 2 3
  • Histone 1, H2ag 2 3
  • Histone H2A/P 3 4
  • H2A.1 3 4
  • H2AFP 3 4
  • HIST1H2AG HIST1H2AI HIST1H2AK HIST1H2AL HIST1H2AM 4
  • H2A.1b 3
  • PH2A/F 3
  • H2A/P 3
  • H2AFC 4
  • H2AFD 4
  • H2AFI 4
  • H2AFN 4
  • H2AG 3

External Ids for HIST1H2AG Gene

Previous HGNC Symbols for HIST1H2AG Gene

  • H2AFP

Previous GeneCards Identifiers for HIST1H2AG Gene

  • GC06P027159
  • GC06P027208
  • GC06P027101
  • GC06P027102
  • GC06P027106
  • GC06P027134
  • GC06P027139
  • GC06P027141

Summaries for HIST1H2AG Gene

Entrez Gene Summary for HIST1H2AG Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2AG Gene

HIST1H2AG (Histone Cluster 1, H2ag) is a Protein Coding gene. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is HIST1H2AM.

UniProtKB/Swiss-Prot for HIST1H2AG Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2AG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AG Gene

Genomics for HIST1H2AG Gene

Regulatory Elements for HIST1H2AG Gene

Promoters for HIST1H2AG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H2AG on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H2AG Gene

Chromosome:
6
Start:
27,133,038 bp from pter
End:
27,135,291 bp from pter
Size:
2,254 bases
Orientation:
Plus strand

Genomic View for HIST1H2AG Gene

Genes around HIST1H2AG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2AG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2AG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AG Gene

Proteins for HIST1H2AG Gene

  • Protein details for HIST1H2AG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0S8-H2A1_HUMAN
    Recommended name:
    Histone H2A type 1
    Protein Accession:
    P0C0S8
    Secondary Accessions:
    • P02261
    • Q2M1R2
    • Q76PA6

    Protein attributes for HIST1H2AG Gene

    Size:
    130 amino acids
    Molecular mass:
    14091 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2AG Gene

neXtProt entry for HIST1H2AG Gene

Proteomics data for HIST1H2AG Gene at MOPED

Post-translational modifications for HIST1H2AG Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys 14 and Lys 16
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AG Gene

Domains & Families for HIST1H2AG Gene

Gene Families for HIST1H2AG Gene

Protein Domains for HIST1H2AG Gene

Graphical View of Domain Structure for InterPro Entry

P0C0S8

UniProtKB/Swiss-Prot:

H2A1_HUMAN :
  • Belongs to the histone H2A family.
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AG: view

No data available for Suggested Antigen Peptide Sequences for HIST1H2AG Gene

Function for HIST1H2AG Gene

Molecular function for HIST1H2AG Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
genes like me logo Genes that share phenotypes with HIST1H2AG: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AG Gene

Localization for HIST1H2AG Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2AG Gene COMPARTMENTS Subcellular localization image for HIST1H2AG gene
Compartment Confidence
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HIST1H2AG Gene

Pathways & Interactions for HIST1H2AG Gene

genes like me logo Genes that share pathways with HIST1H2AG: view

Pathways by source for HIST1H2AG Gene

Gene Ontology (GO) - Biological Process for HIST1H2AG Gene

None

No data available for SIGNOR curated interactions for HIST1H2AG Gene

Drugs & Compounds for HIST1H2AG Gene

(1) Drugs for HIST1H2AG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with HIST1H2AG: view

Transcripts for HIST1H2AG Gene

mRNA/cDNA for HIST1H2AG Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AG Gene

Histone cluster 1, H2ag:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AG Gene

No ASD Table

Relevant External Links for HIST1H2AG Gene

GeneLoc Exon Structure for
HIST1H2AG
ECgene alternative splicing isoforms for
HIST1H2AG

Expression for HIST1H2AG Gene

mRNA expression in normal human tissues for HIST1H2AG Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2AG Gene

This gene is overexpressed in Testis (x7.9) and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for HIST1H2AG Gene

This gene is overexpressed in Saliva (40.4) and Heart (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H2AG Gene



SOURCE GeneReport for Unigene cluster for HIST1H2AG Gene Hs.51011

genes like me logo Genes that share expression patterns with HIST1H2AG: view

Protein tissue co-expression partners for HIST1H2AG Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST1H2AG Gene

Orthologs for HIST1H2AG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H2AG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC529277 35
  • 91.03 (n)
  • 100 (a)
HIST1H2AG 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC488297 35
  • 90 (n)
  • 100 (a)
-- 36
  • 99 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hist1h2an 35
  • 87.95 (n)
  • 98.46 (a)
Hist1h2an 16
Hist1h2af 36
  • 98 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC736529 35
  • 90.26 (n)
  • 99.23 (a)
HIST1H2AG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hist1h2ai 35
  • 86.67 (n)
  • 98.46 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 99 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc56329 35
wheat
(Triticum aestivum)
Liliopsida Ta.644 35
Species with no ortholog for HIST1H2AG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H2AG Gene

ENSEMBL:
Gene Tree for HIST1H2AG (if available)
TreeFam:
Gene Tree for HIST1H2AG (if available)

Paralogs for HIST1H2AG Gene

genes like me logo Genes that share paralogs with HIST1H2AG: view

Variants for HIST1H2AG Gene

Variation tolerance for HIST1H2AG Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2AG Gene

HapMap Linkage Disequilibrium report
HIST1H2AG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AG Gene

Disorders for HIST1H2AG Gene

Relevant External Links for HIST1H2AG

Genetic Association Database (GAD)
HIST1H2AG
Human Genome Epidemiology (HuGE) Navigator
HIST1H2AG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2AG

No disorders were found for HIST1H2AG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AG Gene

Publications for HIST1H2AG Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. The relative expression of human histone H2A genes is similar in different types of proliferating cells. (PMID: 8179821) Mannironi C. … Bonner W. (DNA Cell Biol. 1994) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain. (PMID: 25281266) Lubula M.Y. … Glass K.C. (FEBS Lett. 2014) 3
  5. The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components. (PMID: 23319141) Soldi M. … Bonaldi T. (Mol. Cell Proteomics 2013) 3

Products for HIST1H2AG Gene

Sources for HIST1H2AG Gene

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