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Aliases for HIST1H2AG Gene

Aliases for HIST1H2AG Gene

  • Histone Cluster 1, H2ag 2 3
  • H2AFP 3 4 6
  • H2A Histone Family, Member P 2 3
  • Histone 1, H2ag 2 3
  • Histone H2A/P 3 4
  • H2A.1 3 4
  • H2AG 3 6
  • HIST1H2AG HIST1H2AI HIST1H2AK HIST1H2AL HIST1H2AM 4
  • Histone H2A Type 1 3
  • PH2A/F 3
  • H2A.1b 3
  • H2A/P 3
  • H2AFC 4
  • H2AFD 4
  • H2AFI 4
  • H2AFN 4

External Ids for HIST1H2AG Gene

Previous Symbols for HIST1H2AG Gene

  • H2AFP

Summaries for HIST1H2AG Gene

Entrez Gene Summary for HIST1H2AG Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H2AG Gene

HIST1H2AG (Histone Cluster 1, H2ag) is a Protein Coding gene. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein heterodimerization activity and enzyme binding. An important paralog of this gene is HIST1H2AM.

UniProtKB/Swiss-Prot for HIST1H2AG Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AG Gene

Genomics for HIST1H2AG Gene

Genomic Location for HIST1H2AG Gene

Start:
27,133,038 bp from pter
End:
27,135,291 bp from pter
Size:
2,254 bases
Orientation:
Plus strand

Genomic View for HIST1H2AG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H2AG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AG Gene

Regulatory Elements for HIST1H2AG Gene

Proteins for HIST1H2AG Gene

  • Protein details for HIST1H2AG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0S8-H2A1_HUMAN
    Recommended name:
    Histone H2A type 1
    Protein Accession:
    P0C0S8
    Secondary Accessions:
    • P02261
    • Q2M1R2
    • Q76PA6

    Protein attributes for HIST1H2AG Gene

    Size:
    130 amino acids
    Molecular mass:
    14091 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

    Three dimensional structures from OCA and Proteopedia for HIST1H2AG Gene

neXtProt entry for HIST1H2AG Gene

Proteomics data for HIST1H2AG Gene at MOPED

Post-translational modifications for HIST1H2AG Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys14, Lys16, Lys96, Lys100, and Lys119

Other Protein References for HIST1H2AG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AG Gene

Domains for HIST1H2AG Gene

Gene Families for HIST1H2AG Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H2AG Gene

UniProtKB/Swiss-Prot:

H2A1_HUMAN
Family:
  • Belongs to the histone H2A family.:
    • P0C0S8
genes like me logo Genes that share domains with HIST1H2AG: view

Function for HIST1H2AG Gene

Molecular function for HIST1H2AG Gene

UniProtKB/Swiss-Prot Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Ontology (GO) - Molecular Function for HIST1H2AG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 15161933
GO:0019899 enzyme binding IPI 17980597
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with HIST1H2AG: view

miRNA for HIST1H2AG Gene

miRTarBase miRNAs that target HIST1H2AG

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H2AG Gene

Localization for HIST1H2AG Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AG Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2AG Gene COMPARTMENTS Subcellular localization image for HIST1H2AG gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2AG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 16319397
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with HIST1H2AG: view

Pathways for HIST1H2AG Gene

genes like me logo Genes that share pathways with HIST1H2AG: view

Pathways by source for HIST1H2AG Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for HIST1H2AG Gene
2 KEGG pathways for HIST1H2AG Gene

Gene Ontology (GO) - Biological Process for HIST1H2AG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HIST1H2AG: view

Compounds for HIST1H2AG Gene

(1) HMDB Compounds for HIST1H2AG Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with HIST1H2AG: view

Transcripts for HIST1H2AG Gene

mRNA/cDNA for HIST1H2AG Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AG Gene

Histone cluster 1, H2ag:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AG Gene

No ASD Table

Relevant External Links for HIST1H2AG Gene

GeneLoc Exon Structure for
HIST1H2AG
ECgene alternative splicing isoforms for
HIST1H2AG

Expression for HIST1H2AG Gene

mRNA expression in normal human tissues for HIST1H2AG Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2AG Gene

This gene is overexpressed in Testis (7.9) and Whole Blood (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H2AG Gene

SOURCE GeneReport for Unigene cluster for HIST1H2AG Gene Hs.51011

genes like me logo Genes that share expressions with HIST1H2AG: view

Orthologs for HIST1H2AG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H2AG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2AG 37
  • 100 (a)
OneToOne
LOC736529 36
  • 90.26 (n)
  • 99.23 (a)
cow
(Bos Taurus)
Mammalia HIST1H2AG 37
  • 100 (a)
OneToOne
LOC529277 36
  • 91.03 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 99 (a)
ManyToMany
LOC488297 36
  • 90 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Hist1h2af 37
  • 98 (a)
ManyToMany
Hist1h2ag 16
Hist1h2an 36
  • 87.95 (n)
  • 98.46 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 90 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hist1h2ai 36
  • 86.67 (n)
  • 98.46 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 99 (a)
ManyToMany
-- 37
  • 99 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc56329 36
wheat
(Triticum aestivum)
Liliopsida Ta.644 36
Species with no ortholog for HIST1H2AG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H2AG Gene

ENSEMBL:
Gene Tree for HIST1H2AG (if available)
TreeFam:
Gene Tree for HIST1H2AG (if available)

Paralogs for HIST1H2AG Gene

genes like me logo Genes that share paralogs with HIST1H2AG: view

Variants for HIST1H2AG Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AG Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs35503649 -- 27,131,766(+) AAAAA(-/AGA)CTGAT upstream-variant-2KB
rs58602580 -- 27,131,400(+) ATAAA(A/G)GGAAA upstream-variant-2KB
rs114703767 -- 27,131,410(+) AATAG(C/T)ATTCT upstream-variant-2KB
rs142467298 -- 27,131,808(+) AAAAC(G/T)CTCTA upstream-variant-2KB
rs146791705 -- 27,131,658(+) GTGAA(A/G)CAGGA upstream-variant-2KB

Relevant External Links for HIST1H2AG Gene

HapMap Linkage Disequilibrium report
HIST1H2AG

No data available for Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AG Gene

Disorders for HIST1H2AG Gene

Relevant External Links for HIST1H2AG

Genetic Association Database (GAD)
HIST1H2AG
Human Genome Epidemiology (HuGE) Navigator
HIST1H2AG
genes like me logo Genes that share disorders with HIST1H2AG: view

No data available for UniProtKB/Swiss-Prot for HIST1H2AG Gene

Publications for HIST1H2AG Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  2. The relative expression of human histone H2A genes is similar in different types of proliferating cells. (PMID: 8179821) Mannironi C. … Bonner W. (DNA Cell Biol. 1994) 2 3 4
  3. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 3 4
  4. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne M.T. II … Kelleher N.L. (J. Proteome Res. 2006) 3 4
  5. The human H2A and H2B histone gene complement. (PMID: 10064132) Albig W. … Doenecke D. (Biol. Chem. 1999) 3 4

Products for HIST1H2AG Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HIST1H2AG
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H2AG
  • Block miRNA regulation of HIST1H2AG using miScript Target Protectors

Sources for HIST1H2AG Gene

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