Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST1H2AG Gene

Aliases for HIST1H2AG Gene

  • Histone Cluster 1 H2A Family Member G 2 3 5
  • H2A Histone Family, Member P 2 3
  • Histone Cluster 1, H2ag 2 3
  • Histone 1, H2ag 2 3
  • Histone H2A/Ptl 3 4
  • H2A.1 3 4
  • H2AFP 3 4
  • HIST1H2AG HIST1H2AI HIST1H2AK HIST1H2AL HIST1H2AM 4
  • Histone H2A Type 1 3
  • Histone H2A/P 3
  • H2A.1b 3
  • PH2A/F 3
  • H2A/P 3
  • H2AFC 4
  • H2AFD 4
  • H2AFI 4
  • H2AFN 4
  • H2AG 3

External Ids for HIST1H2AG Gene

Previous HGNC Symbols for HIST1H2AG Gene

  • H2AFP

Previous GeneCards Identifiers for HIST1H2AG Gene

  • GC06P027159
  • GC06P027208
  • GC06P027101
  • GC06P027102
  • GC06P027106
  • GC06P027134
  • GC06P027139
  • GC06P027141
  • GC06P027142
  • GC06P027143
  • GC06P027144
  • GC06P027145
  • GC06P027146

Summaries for HIST1H2AG Gene

Entrez Gene Summary for HIST1H2AG Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2AG Gene

HIST1H2AG (Histone Cluster 1 H2A Family Member G) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is HIST1H2AI.

UniProtKB/Swiss-Prot for HIST1H2AG Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2AG Gene

Additional gene information for HIST1H2AG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AG Gene

Genomics for HIST1H2AG Gene

GeneHancer (GH) Regulatory Elements for HIST1H2AG Gene

Promoters and enhancers for HIST1H2AG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I027126 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 550.8 +5.0 4984 23 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC HIST1H2AH GC06P027140 HIST1H2AG HIST1H4I HIST1H2BJ HIST1H2BK ZKSCAN8 ABT1 HMGN4 BTN2A1
GH06I027176 Enhancer 1.6 FANTOM5 Ensembl ENCODE 1.5 +44.6 44575 3.2 HDGF PKNOX1 SMAD1 ARNT SIN3A ZNF2 YY1 ZNF213 E2F8 ZNF143 TRI-AAT5-2 BTN3A2 ZKSCAN8 BTN2A2 ABT1 BTN2A1 ZNF204P HMGN4 ZNF391 HIST1H2BK
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HIST1H2AG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HIST1H2AG gene promoter:

Genomic Locations for HIST1H2AG Gene

Genomic Locations for HIST1H2AG Gene
chr6:27,133,038-27,135,291
(GRCh38/hg38)
Size:
2,254 bases
Orientation:
Plus strand
chr6:27,100,817-27,103,070
(GRCh37/hg19)

Genomic View for HIST1H2AG Gene

Genes around HIST1H2AG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2AG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2AG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AG Gene

Proteins for HIST1H2AG Gene

  • Protein details for HIST1H2AG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C0S8-H2A1_HUMAN
    Recommended name:
    Histone H2A type 1
    Protein Accession:
    P0C0S8
    Secondary Accessions:
    • P02261
    • Q2M1R2
    • Q76PA6

    Protein attributes for HIST1H2AG Gene

    Size:
    130 amino acids
    Molecular mass:
    14091 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2AG Gene

neXtProt entry for HIST1H2AG Gene

Post-translational modifications for HIST1H2AG Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at isoforms=14 and isoforms=16

Other Protein References for HIST1H2AG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AG Gene

Domains & Families for HIST1H2AG Gene

Gene Families for HIST1H2AG Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HIST1H2AG Gene

Graphical View of Domain Structure for InterPro Entry

P0C0S8

UniProtKB/Swiss-Prot:

H2A1_HUMAN :
  • Belongs to the histone H2A family.
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AG: view

No data available for Suggested Antigen Peptide Sequences for HIST1H2AG Gene

Function for HIST1H2AG Gene

Molecular function for HIST1H2AG Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Phenotypes From GWAS Catalog for HIST1H2AG Gene

Gene Ontology (GO) - Molecular Function for HIST1H2AG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0005515 protein binding IPI 15161933
GO:0019899 enzyme binding IPI 17980597
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2AG: view
genes like me logo Genes that share phenotypes with HIST1H2AG: view

Animal Model Products

miRNA for HIST1H2AG Gene

miRTarBase miRNAs that target HIST1H2AG

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AG Gene

Localization for HIST1H2AG Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AG Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H2AG gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2AG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IDA 16319397
GO:0005694 chromosome IEA --
GO:0070062 extracellular exosome HDA,IDA 20458337
genes like me logo Genes that share ontologies with HIST1H2AG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HIST1H2AG Gene

Pathways & Interactions for HIST1H2AG Gene

genes like me logo Genes that share pathways with HIST1H2AG: view

Pathways by source for HIST1H2AG Gene

Interacting Proteins for HIST1H2AG Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352119%0d%0a9606.ENSP00000308405%0d%0a9606.ENSP00000296417%0d%0a9606.ENSP00000357887%0d%0a9606.ENSP00000376204%0d%0a9606.ENSP00000350275%0d%0a
Selected Interacting proteins: ENSP00000352119 P0C0S8-H2A1_HUMAN for HIST1H2AG Gene via STRING MINT IID UniProtKB

Symbol External ID(s) Details
IL33
YWHAZ
RYBP
BRPF1
DNAJC2

Gene Ontology (GO) - Biological Process for HIST1H2AG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006342 chromatin silencing IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with HIST1H2AG: view

No data available for SIGNOR curated interactions for HIST1H2AG Gene

Drugs & Compounds for HIST1H2AG Gene

(1) Drugs for HIST1H2AG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with HIST1H2AG: view

Transcripts for HIST1H2AG Gene

mRNA/cDNA for HIST1H2AG Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AG Gene

Histone cluster 1, H2ag:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AG Gene

No ASD Table

Relevant External Links for HIST1H2AG Gene

GeneLoc Exon Structure for
HIST1H2AG
ECgene alternative splicing isoforms for
HIST1H2AG

Expression for HIST1H2AG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H2AG Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2AG Gene

This gene is overexpressed in Testis (x7.9) and Whole Blood (x4.7).

Protein differential expression in normal tissues from HIPED for HIST1H2AG Gene

This gene is overexpressed in Saliva (40.4) and Heart (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H2AG Gene



Protein tissue co-expression partners for HIST1H2AG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HIST1H2AG Gene:

HIST1H2AG

SOURCE GeneReport for Unigene cluster for HIST1H2AG Gene:

Hs.51011

Evidence on tissue expression from TISSUES for HIST1H2AG Gene

  • Intestine(4.2)
  • Spleen(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with HIST1H2AG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2AG Gene

Orthologs for HIST1H2AG Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H2AG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIST1H2AG 34
  • 100 (a)
OneToOne
LOC529277 33
  • 91.03 (n)
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2AG 34
  • 100 (a)
OneToOne
LOC736529 33
  • 90.26 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
ManyToMany
LOC488297 33
  • 90 (n)
mouse
(Mus musculus)
Mammalia Hist1h2af 34
  • 98 (a)
ManyToMany
Hist1h2an 33 16
  • 87.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 90 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hist1h2ai 33
  • 86.67 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 99 (a)
ManyToMany
-- 34
  • 99 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii zgc56329 33
wheat
(Triticum aestivum)
Liliopsida Ta.644 33
Species where no ortholog for HIST1H2AG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H2AG Gene

ENSEMBL:
Gene Tree for HIST1H2AG (if available)
TreeFam:
Gene Tree for HIST1H2AG (if available)

Paralogs for HIST1H2AG Gene

Variants for HIST1H2AG Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AG Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000107163 -- 27,131,958(+) G/A upstream_transcript_variant
rs1001283944 -- 27,133,597(+) C/T downstream_transcript_variant
rs1001313399 -- 27,133,468(+) T/C 3_prime_UTR_variant
rs1005075620 -- 27,132,276(+) C/T upstream_transcript_variant
rs1006198827 -- 27,133,752(+) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AG Gene

Variant ID Type Subtype PubMed ID
nsv1029124 CNV loss 25217958
nsv970090 CNV duplication 23825009

Variation tolerance for HIST1H2AG Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HIST1H2AG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H2AG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AG Gene

Disorders for HIST1H2AG Gene

Additional Disease Information for HIST1H2AG

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for HIST1H2AG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AG Gene

Publications for HIST1H2AG Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff WF … Maltais LJ (Genomics 2002) 2 3 4 58
  2. The relative expression of human histone H2A genes is similar in different types of proliferating cells. (PMID: 8179821) Mannironi C … Bonner W (DNA and cell biology 1994) 2 3 4 58
  3. Common variants on chromosome 6p22.1 are associated with schizophrenia. (PMID: 19571809) Shi J … Gejman PV (Nature 2009) 3 44 58
  4. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne MT … Kelleher NL (Journal of proteome research 2006) 3 4 58
  5. The human H2A and H2B histone gene complement. (PMID: 10064132) Albig W … Doenecke D (Biological chemistry 1999) 3 4 58

Products for HIST1H2AG Gene

Sources for HIST1H2AG Gene

Content
Loading form....