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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2AG Gene

protein-coding   GIFtS: 57
GCID: GC06P027106

Histone Cluster 1, H2ag

(Previous names: H2A histone family, member P, histone 1, H2ag)
(Previous symbol: H2AFP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H2ag1 2     H2AG2
H2AFP1 2 3     Histone H2A Type 12
H2A Histone Family, Member P1 2     pH2A/f2
Histone 1, H2ag1 2     H2AFC3
Histone H2A/P2 3     H2AFD3
H2A.12 3     H2AFI3
H2A.1b2     H2AFN3
H2A/p2     

External Ids:    HGNC: 47371   Entrez Gene: 89692   Ensembl: ENSG000001967877   OMIM: 6150125   UniProtKB: P0C0S83   

Export aliases for HIST1H2AG gene to outside databases

Previous GC identifers: GC06P027159 GC06P027208 GC06P027101 GC06P027102


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2AG Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on
chromosome 6p21.33. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2AG Gene: 
HIST1H2AG (histone cluster 1, H2ag) is a protein-coding gene. Diseases associated with HIST1H2AG include riddle syndrome, and systemic lupus erythematosus, and among its related super-pathways are Signal transduction Activin A signaling regulation and Systemic lupus erythematosus. GO annotations related to this gene include enzyme binding and protein heterodimerization activity. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2AG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2AG gene promoter:
         AML1a   Pax-5   GCNF   E2F-1   E2F   GCNF-1   FOXO4   ZID   GCNF-2   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2AG promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2AG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2AG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H2AG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AG gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P027106:  view genomic region     (about GC identifiers)

Start:
27,100,817 bp from pter      End:
27,103,070 bp from pter
Size:
2,254 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8 (See protein sequence)
Recommended Name: Histone H2A type 1  
Size: 130 amino acids; 14091 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=13993.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Secondary accessions: P02261 Q2M1R2 Q76PA6

Explore the universe of human proteins at neXtProt for HIST1H2AG: NX_P0C0S8

Explore proteomics data for HIST1H2AG at MOPED 

Post-translational modifications:

  • UniProtKB: The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)
  • UniProtKB: Deiminated on Arg-4 in granulocytes upon calcium entry
  • UniProtKB: Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events
  • UniProtKB: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1
  • UniProtKB: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0C0S8

  • HIST1H2AG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H2AG Protein Expression
    REFSEQ proteins: NP_066408.1  
    ENSEMBL proteins: 
     ENSP00000352119  

    Human Recombinant Protein Products for HIST1H2AG: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H2AG 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    HIST1H2AG for ontologies           About GeneDecksing



    HIST1H2AG Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P0C0S8

    ProtoNet protein and cluster: P0C0S8

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1_HUMAN, P0C0S8
    Similarity: Belongs to the histone H2A family


    HIST1H2AG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A1_HUMAN, P0C0S8
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI15161933
    GO:0019899enzyme binding IPI17980597
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    HIST1H2AG for ontologies           About GeneDecksing


    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H2AG About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2AG
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2AG
        Signal transduction Activin A signaling regulation



    2         Kegg Pathways  (Kegg details for HIST1H2AG):
        Alcoholism
    Systemic lupus erythematosus


    HIST1H2AG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2AG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/87 Interacting proteins for HIST1H2AG (P0C0S82, 3 ENSP000003521194) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IL33O957602, 3MINT-6802691 MINT-6802770 MINT-6802833 I2D: score=1 
    RYBPQ8N4882, 3MINT-3973842 MINT-3973898 I2D: score=1 
    YWHAZP631042, 3MINT-3296701 MINT-7899812 I2D: score=1 
    YWHAQP273482, 3MINT-7899812 I2D: score=1 
    SAP30O754463, ENSP000002965044I2D: score=2 STRING: ENSP00000296504
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    HIST1H2AG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2AG (H2A1)

    1 HMDB Compound for HIST1H2AG    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about HIST1H2AG / H2A1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H2AG gene: 
    NM_021064.4  

    Unigene Cluster for HIST1H2AG:

    Histone cluster 1, H2ag
    Hs.51011  [show with all ESTs]
    Unigene Representative Sequence: BC067782
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000359193(uc003niw.3)
    miRNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AG

    Additional mRNA sequence: 

    AK312124.1 BC016677.1 BC067782.1 L19778.1 

    2 DOTS entries:

    DT.95189451  DT.91859377 

    12 AceView cDNA sequences:

    BQ018631 BM759702 BC016677 NM_021064 BU659312 BI256323 BE893194 R16851 
    BC067782 AA419197 BE613016 BI669076 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2AG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H2AG Expression
    About this image


    See HIST1H2AG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2AG

    SOURCE GeneReport for Unigene cluster: Hs.51011
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2AG gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2ag5
    Hist1h2ah1
    histone cluster 1, H2ag5
    histone cluster 1, H2ah1
    88.8(n)1
    98.44(a)1
      13 (8.15 cM)5
    3191681  NM_175659.11  NP_783590.11 
     220424605 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563292 similar to H2A histone family, member X 79(n)   394048  BC046078.1 
    wheat
    (Triticum aestivum)
    Liliopsida Ta.6442 Triticum aestivum mRNA for protein H2A, complete cds, more 77.02(n)    D38089.1 


    ENSEMBL Gene Tree for HIST1H2AG (if available)
    TreeFam Gene Tree for HIST1H2AG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2AG gene
    HIST1H2AI1 2  HIST1H2AL1 2  HIST1H2AK1 2  HIST1H2AM1 2  HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  
    HIST1H2AC2  HIST1H2AH2  HIST1H2AJ2  HIST2H2AA42  HIST1H2AA2  HIST1H2AE2  HIST2H2AC2  HIST1H2AB2  
    H2AFJ2  
    18/23 SIMAP similar genes for HIST1H2AG using alignment to 1 protein entry:     H2A1_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AH    HIST1H2AJ
    HIST1H2AK    HIST2H2AA3    HIST2H2AA4    HIST3H2A    H2AFJ    HIST1H2AA
    HIST2H2AB    HIST2H2AC    H2AFX    HIST1H2APS4    H2AFZ    H2AFB2

    HIST1H2AG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/15 SNPs in HIST1H2AG are shown (see all 15)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1897820241,2
    --27098991(+) TGTTTC/TTCCTC 1 -- us2k10--------
    rs586025801,2
    C--27099179(+) ATAAAG/AGGAAA 1 -- us2k12Minor allele frequency- A:0.16WA 120
    rs1147037671,2
    C,F--27099189(+) AATAGT/CATTCT 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1829983531,2
    --27099215(+) ATTGAC/TCTTTC 1 -- us2k10--------
    rs1871203071,2
    --27099255(+) CGTTGG/TAGCCG 1 -- us2k10--------
    rs1924574921,2
    --27099260(+) TAGCCA/GGGCTT 1 -- us2k10--------
    rs1832509171,2
    --27099404(+) GGCGCA/GTGCCT 1 -- us2k10--------
    rs1875187891,2
    --27099427(+) ACACGA/GAAGGG 1 -- us2k10--------
    rs1467917051,2
    --27099437(+) GTGAAA/GCAGGA 1 -- us2k10--------
    rs1424672981,2
    C--27099587(+) AAAACG/TCTCTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2AG (27100817 - 27103070 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for HIST1H2AG: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2AG
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615012    OMIM disorders: --

    4 diseases for HIST1H2AG:    About MalaCards
    riddle syndrome    systemic lupus erythematosus    lupus erythematosus    schizophrenia


    HIST1H2AG for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIST1H2AG
    Human Genome Epidemiology (HuGE) Navigator: HIST1H2AG (1 document)

    Export disorders for HIST1H2AG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2AG gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with HIST1H2AG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The relative expression of human histone H2A genes is similar in different types of proliferating cells. (PubMed id 8179821)1, 2, 3 Mannironi C.... Bonner W. (1994)
    3. Common variants on chromosome 6p22.1 are associated w ith schizophrenia. (PubMed id 19571809)1, 4 Shi J....Gejman P.V. (2009)
    4. The human H2A and H2B histone gene complement. (PubMed id 10064132)1, 2 Albig W.... Doenecke D. (1999)
    5. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2 Albig W. and Doenecke D. (1997)
    6. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (2012)
    7. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8969 HGNC: 4737 AceView: HIST1H2AG Ensembl:ENSG00000196787 euGenes: HUgn8969
    ECgene: HIST1H2AG Kegg: 8969 H-InvDB: HIST1H2AG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2AG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H2AG gene:
    Search GeneIP for patents involving HIST1H2AG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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