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HIST1H2AE Gene

protein-coding   GIFtS: 53
GCID: GC06P026295

Histone Cluster 1, H2ae

(Previous names: H2A histone family, member A, histone 1, H2ae)
(Previous symbol: H2AFA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H2ae1 2     H2A/a2
H2AFA1 2 3 5     Histone H2A Type 1-B/E2
H2A Histone Family, Member A1 2     Histone H2AE2
Histone 1, H2ae1 2     H2AFM3
Histone H2A/A2 3     Histone H2A.23
H2A.12     Histone H2A/M3
H2A.22     

External Ids:    HGNC: 47241   Entrez Gene: 30122   Ensembl: ENSG000001682747   OMIM: 6027865   UniProtKB: P049083   

Export aliases for HIST1H2AE gene to outside databases

Previous GC identifers: GC06P026275 GC06P026325 GC06P026218 GC06P026160 GC06P026220 GC06P026221 GC06P026222 GC06P026228 GC06P026249 GC06P026255


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H2AE Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene
lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large
histone gene cluster on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2AE Gene:
HIST1H2AE (histone cluster 1, H2ae) is a protein-coding gene. Diseases associated with HIST1H2AE include riddle syndrome, and tonsillitis. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2AE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H2AE gene promoter:
         AhR   GCNF   Olf-1   XBP-1   Arnt   GATA-1   AREB6   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2AE promoter sequence
   Search Chromatin IP Primers for HIST1H2AE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2AE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2AE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AE gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026295:  view genomic region     (about GC identifiers)

Start:
26,217,148 bp from pter      End:
26,217,711 bp from pter
Size:
564 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908 (See protein sequence)
Recommended Name: Histone H2A type 1-B/E  
Size: 130 amino acids; 14135 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Mass spectrometry: Mass=14037.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Selected PDB 3D structures from and Proteopedia for HIST1H2AE (see all 21):
2CV5 (3D)        3A6N (3D)        3AFA (3D)        3AN2 (3D)        3AV1 (3D)        3AV2 (3D)    
Secondary accessions: P28001 Q76P63

Explore the universe of human proteins at neXtProt for HIST1H2AE: NX_P04908

Explore proteomics data for HIST1H2AE at MOPED

Post-translational modifications: 

  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly
    represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at
    Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates
    their transcription1
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at
    35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239)1
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Ubiquitination2 at Lys14, Lys16, Lys96, Lys119
  • Modification sites at PhosphoSitePlus

  • See HIST1H2AE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066390.1  
    ENSEMBL proteins: 
     ENSP00000303373  
    Reactome Protein details: P04908

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P04908

    ProtoNet protein and cluster: P04908

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908
    Similarity: Belongs to the histone H2A family


    HIST1H2AE for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A1B_HUMAN, P04908
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity ----
         
    HIST1H2AE for ontologies           About GeneDecksing


    Animal Models:
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    miRTarBase miRNAs that target HIST1H2AE:
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    Block miRNA regulation of human, mouse, rat HIST1H2AE using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H2A1B_HUMAN, P04908: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome ----
    GO:0005622intracellular ----
    GO:0005634nucleus ----

    HIST1H2AE for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H2AE About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    Mitotic Prophase0.56
    RNA Polymerase I Chain Elongation0.78
    Systemic lupus erythematosus0.40
    RNA Polymerase I Promoter Clearance0.78
    Chromatin modifying enzymes0.34
    RNA Polymerase I Promoter Opening0.78
    HATs acetylate histones0.34
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.66
    Chromosome Maintenance0.62
    Meiotic Synapsis0.66
    Nucleosome assembly0.59
    DNA Damage/Telomere Stress Induced Senescence0.65
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Telomere Maintenance0.64
    3Cellular Senescence
    Cellular Senescence0.81
    Oxidative Stress Induced Senescence0.64
    Cellular responses to stress0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HIST1H2AE
        Proteasome Degradation

    Selected Reactome Pathways for HIST1H2AE (see all 16)
        HATs acetylate histones
    NoRC negatively regulates rRNA expression
    formation of the beta-catenin:TCF transactivating complex
    PRC2 methylates histones and DNA
    RNA Polymerase I Chain Elongation


    2 Kegg Pathways  (Kegg details for HIST1H2AE):
        Alcoholism
    Systemic lupus erythematosus


    HIST1H2AE for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H2AE
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H2AE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H2AE (P049082, 3 ENSP000003033734) via UniProtKB, MINT, STRING, and/or I2D (see all 207)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly ----

    HIST1H2AE for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H2AE (H2A1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H2AE gene: 
    NM_021052.2  

    Unigene Cluster for HIST1H2AE:

    Histone cluster 1, H2ae
    Hs.121017  [show with all ESTs]
    Unigene Representative Sequence: BE741093
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303910(uc003nha.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AE
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AE

    Additional mRNA sequence: 

    BC093836.1 BC093862.1 

    1 DOTS entry:

    DT.91758511 

    19 AceView cDNA sequences:

    NM_021052 BP366736 BG014680 AI209184 BP353496 AW996520 AA436989 AA426351 
    AW206552 BM833122 BG014672 AA703397 AA603612 AI039144 AV763030 BF222420 
    BE741093 AA639680 CA337081 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H2AE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H2AE Expression
    About this image


    HIST1H2AE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    HIST1H2AE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H2AE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.121017
        Custom PCR Arrays for HIST1H2AE
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2AE gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2ae5
    Hist1h2ai1
    histone cluster 1, H2ae5
    histone cluster 1, H2ai1
    86.41(n)1
    100(a)1
      13 (9.80 cM)5
    3191911  NM_178182.11  NP_835489.11 
     235706625 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Histone H2A
    99(a)
    99(a)
    many ↔ many
    many ↔ many
    GL343466.1(242198-242587)
    GL343220.1(86772-87161)
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.94512 Vitis vinifera transcribed sequence with moderate similarity more 74.68(n)    CF513510.1 


    ENSEMBL Gene Tree for HIST1H2AE (if available)
    TreeFam Gene Tree for HIST1H2AE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H2AE gene
    HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  
    HIST1H2AH2  HIST1H2AM2  HIST1H2AJ2  HIST1H2AA2  HIST2H2AA42  HIST1H2AB2  HIST2H2AC2  HIST1H2AK2  
    HIST1H2AL2  H2AFJ2  
    Selected SIMAP similar genes for HIST1H2AE using alignment to 1 protein entry:     H2A1B_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AG    HIST1H2AH    HIST1H2AI
    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST2H2AA3    HIST2H2AA4
    HIST3H2A    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX

    HIST1H2AE for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    10 SNPs for HIST1H2AE    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919994821,2
    --26215194(+) GTCTCC/TGAAGT 1 -- us2k10--------
    rs1475098251,2
    --26215254(+) TTTTAA/GTAGAT 1 -- us2k10--------
    rs1811836601,2
    --26215308(+) CCTCAA/GGTGAT 1 -- us2k10--------
    rs715446731,2
    C--26215386(+) TGTAATTT/-TTTTT 2 -- us2k1 cds11Minor allele frequency- -:0.50NA 2
    rs709772611,2
    C--26215413(+) TTTTT-/TTT   
       
    /TTTT
    ATGAG
    2 -- us2k1 cds11NA 2
    rs1400086431,2
    --26215425(+) AGATGG/TAATCT 1 -- us2k10--------
    rs1454341401,2
    --26215703(+) ACGGCA/GGAAAA 1 -- us2k10--------
    rs1476721141,2
    --26215781(+) GAGTGA/CTCAGA 1 -- us2k10--------
    rs117556181,2
    C,F,H--26215802(+) TTGTTA/GTCAGG 1 -- us2k1 tfbs320Minor allele frequency- G:0.10NS EA NA WA 2482
    rs1420421941,2
    ----26215590(+) TAGTAA/GAGACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2AE (26217148 - 26217711 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H2AE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883490CNV Loss21882294
    nsv428137CNV Loss18775914

    Human Gene Mutation Database (HGMD): HIST1H2AE
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H2AE
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H2AE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602786    OMIM disorders: --

    10 diseases for HIST1H2AE:    
    About MalaCards
    riddle syndrome    tonsillitis    systemic lupus erythematosus    hiv-1
    lupus erythematosus    neuroblastoma    cerebritis    thyroiditis
    endotheliitis    prostatitis


    HIST1H2AE for disorders           About GeneDecksing


    Export disorders for HIST1H2AE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H2AE gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with HIST1H2AE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2, 3 Albig W.... Doenecke D. (Genomics 1991)
    3. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (Genes Dev. 2006)
    4. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PubMed id 16457589)1, 2 Boyne M.T. II... Kelleher N.L. (J. Proteome Res. 2006)
    5. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (Biochemistry 2005)
    6. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (Mol. Cell 2005)
    7. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (Nature 2004)
    8. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (J. Biol. Chem. 2004)
    9. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)1, 2 Aihara H.... Ito T. (Genes Dev. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3012 HGNC: 4724 AceView: HIST1H2AE Ensembl:ENSG00000168274 euGenes: HUgn3012
    ECgene: HIST1H2AE Kegg: 3012 H-InvDB: HIST1H2AE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H2AE Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H2AE gene:
    Search GeneIP for patents involving HIST1H2AE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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