Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST1H2AE Gene

Aliases for HIST1H2AE Gene

  • Histone Cluster 1, H2ae 2 3 5
  • H2A Histone Family, Member A 2 3
  • Histone 1, H2ae 2 3
  • Histone H2A/A 3 4
  • H2AFA 3 4
  • HIST1H2AB HIST1H2AE 4
  • Histone H2A.2 4
  • Histone H2A/M 4
  • Histone H2AE 3
  • H2AFM 4
  • H2A.1 3
  • H2A.2 3
  • H2A/A 3

External Ids for HIST1H2AE Gene

Previous HGNC Symbols for HIST1H2AE Gene

  • H2AFA

Previous GeneCards Identifiers for HIST1H2AE Gene

  • GC06P026275
  • GC06P026325
  • GC06P026218
  • GC06P026160
  • GC06P026220
  • GC06P026221
  • GC06P026222
  • GC06P026228
  • GC06P026249
  • GC06P026255
  • GC06P026295
  • GC06P026265
  • GC06P026358

Summaries for HIST1H2AE Gene

Entrez Gene Summary for HIST1H2AE Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2AE Gene

HIST1H2AE (Histone Cluster 1, H2ae) is a Protein Coding gene. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2AM.

UniProtKB/Swiss-Prot for HIST1H2AE Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2AE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AE Gene

Genomics for HIST1H2AE Gene

Regulatory Elements for HIST1H2AE Gene

Promoters for HIST1H2AE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H2AE on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H2AE Gene

Chromosome:
6
Start:
26,216,920 bp from pter
End:
26,217,483 bp from pter
Size:
564 bases
Orientation:
Plus strand

Genomic View for HIST1H2AE Gene

Genes around HIST1H2AE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2AE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2AE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AE Gene

Proteins for HIST1H2AE Gene

  • Protein details for HIST1H2AE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04908-H2A1B_HUMAN
    Recommended name:
    Histone H2A type 1-B/E
    Protein Accession:
    P04908
    Secondary Accessions:
    • P28001
    • Q76P63

    Protein attributes for HIST1H2AE Gene

    Size:
    130 amino acids
    Molecular mass:
    14135 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2AE Gene

neXtProt entry for HIST1H2AE Gene

Proteomics data for HIST1H2AE Gene at MOPED

Post-translational modifications for HIST1H2AE Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys 14 and Lys 16
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AE Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for HIST1H2AE

No data available for DME Specific Peptides for HIST1H2AE Gene

Domains & Families for HIST1H2AE Gene

Gene Families for HIST1H2AE Gene

Protein Domains for HIST1H2AE Gene

Suggested Antigen Peptide Sequences for HIST1H2AE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04908

UniProtKB/Swiss-Prot:

H2A1B_HUMAN :
  • Belongs to the histone H2A family.
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AE: view

Function for HIST1H2AE Gene

Molecular function for HIST1H2AE Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
genes like me logo Genes that share phenotypes with HIST1H2AE: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HIST1H2AE

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AE Gene

Localization for HIST1H2AE Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AE Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H2AE Gene COMPARTMENTS Subcellular localization image for HIST1H2AE gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for HIST1H2AE Gene

Pathways & Interactions for HIST1H2AE Gene

SuperPathways for HIST1H2AE Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 Cellular Senescence
3 Chromosome Maintenance
4 Mitotic Prophase
5 Cell Cycle, Mitotic
.61
genes like me logo Genes that share pathways with HIST1H2AE: view

Pathways by source for HIST1H2AE Gene

1 BioSystems pathway for HIST1H2AE Gene
2 KEGG pathways for HIST1H2AE Gene

Gene Ontology (GO) - Biological Process for HIST1H2AE Gene

None

No data available for SIGNOR curated interactions for HIST1H2AE Gene

Drugs & Compounds for HIST1H2AE Gene

No Compound Related Data Available

Transcripts for HIST1H2AE Gene

mRNA/cDNA for HIST1H2AE Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AE Gene

Histone cluster 1, H2ae:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AE Gene

No ASD Table

Relevant External Links for HIST1H2AE Gene

GeneLoc Exon Structure for
HIST1H2AE
ECgene alternative splicing isoforms for
HIST1H2AE

Expression for HIST1H2AE Gene

mRNA expression in normal human tissues for HIST1H2AE Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2AE Gene

This gene is overexpressed in Whole Blood (x6.5) and Prostate (x4.8).

Protein differential expression in normal tissues from HIPED for HIST1H2AE Gene

This gene is overexpressed in Monocytes (17.3), Neutrophil (13.2), Adipocyte (10.7), Blymphocyte (10.3), and Tlymphocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HIST1H2AE Gene



SOURCE GeneReport for Unigene cluster for HIST1H2AE Gene Hs.121017

genes like me logo Genes that share expression patterns with HIST1H2AE: view

Protein tissue co-expression partners for HIST1H2AE Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST1H2AE Gene

Orthologs for HIST1H2AE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H2AE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC748495 35
  • 83.85 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HIST3H2A 35
  • 81.79 (n)
  • 99.23 (a)
dog
(Canis familiaris)
Mammalia HIST3H2A 35
  • 85.64 (n)
  • 98.46 (a)
mouse
(Mus musculus)
Mammalia Hist1h2ai 35
  • 86.41 (n)
  • 100 (a)
Hist1h2ai 16
rat
(Rattus norvegicus)
Mammalia Hist1h2ac 35
  • 84.87 (n)
  • 100 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9451 35
Species with no ortholog for HIST1H2AE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AE Gene

ENSEMBL:
Gene Tree for HIST1H2AE (if available)
TreeFam:
Gene Tree for HIST1H2AE (if available)

Paralogs for HIST1H2AE Gene

genes like me logo Genes that share paralogs with HIST1H2AE: view

Variants for HIST1H2AE Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AE Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs11755618 -- 26,215,574(+) TTGTT(A/G)TCAGG upstream-variant-2KB
rs145434140 -- 26,215,475(+) ACGGC(A/G)GAAAA upstream-variant-2KB
rs147672114 -- 26,215,553(+) GAGTG(A/C)TCAGA upstream-variant-2KB
rs529717094 -- 26,215,142(+) CCCAG(A/C)CAGCC upstream-variant-2KB
rs191999482 -- 26,214,966(+) GTCTC(C/T)GAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AE Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914
nsv883490 CNV Loss 21882294

Variation tolerance for HIST1H2AE Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2AE Gene

HapMap Linkage Disequilibrium report
HIST1H2AE
Human Gene Mutation Database (HGMD)
HIST1H2AE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AE Gene

Disorders for HIST1H2AE Gene

Relevant External Links for HIST1H2AE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2AE

No disorders were found for HIST1H2AE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AE Gene

Publications for HIST1H2AE Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3
  3. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PMID: 1916825) Albig W. … Doenecke D. (Genomics 1991) 2 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Quantitative Lys-I/-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson J.W. … Luchansky S.J. (J. Biol. Chem. 2014) 3

Products for HIST1H2AE Gene

  • Cloud-Clone Corp. Antibodies for HIST1H2AE
  • Cloud-Clone Corp. Proteins for HIST1H2AE
  • Cloud-Clone Corp Assay Kits for HIST1H2AE

Sources for HIST1H2AE Gene

Back to Top

Content