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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2AD Gene

protein-coding   GIFtS: 47
GCID: GC06M026199

Histone Cluster 1, H2ad

(Previous names: H2A histone family, member G, histone 1, H2ad)
(Previous symbol: H2AFG)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H2ad1 2     Histone H2A/G2 3
H2AFG1 2 3 5     H2A.32
H2A Histone Family, Member G1 2     H2A/g2
Histone 1, H2ad1 2     Histone H2A Type 1-D2
Histone H2A.32 3     Histone H2AD2

External Ids:    HGNC: 47291   Entrez Gene: 30132   Ensembl: ENSG000001968667   OMIM: 6027925   UniProtKB: P206713   

Export aliases for HIST1H2AD gene to outside databases

Previous GC identifers: GC06M026256 GC06M026309 GC06M026311 GC06M026313 GC06M026315 GC06M026142


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2AD Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer
composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further
compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher
order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts
from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in
the large histone gene cluster on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2AD Gene: 
HIST1H2AD (histone cluster 1, H2ad) is a protein-coding gene. Diseases associated with HIST1H2AD include riddle syndrome, and systemic lupus erythematosus, and among its related super-pathways are Signal transduction Activin A signaling regulation and Telomere Maintenance. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A1D_HUMAN, P20671
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2AD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2AD gene promoter:
         AhR   AML1a   GCNF   GCNF-1   Olf-1   XBP-1   GCNF-2   Arnt   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIST1H2AD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2AD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2AD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AD gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026199:  view genomic region     (about GC identifiers)

Start:
26,199,012 bp from pter      End:
26,199,471 bp from pter
Size:
460 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H2A1D_HUMAN, P20671 (See protein sequence)
Recommended Name: Histone H2A type 1-D  
Size: 130 amino acids; 14107 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=14009.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Caution: Was originally (PubMed:2587222) thought to originate from mouse
Secondary accessions: A0PK91 P57754 Q6FGY6

Explore the universe of human proteins at neXtProt for HIST1H2AD: NX_P20671

Explore proteomics data for HIST1H2AD at MOPED 

Post-translational modifications:

  • UniProtKB: The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)
  • UniProtKB: Deiminated on Arg-4 in granulocytes upon calcium entry
  • UniProtKB: Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events
  • UniProtKB: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1
  • UniProtKB: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View neXtProt modification sites for NX_P20671

  • HIST1H2AD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H2AD Protein Expression
    REFSEQ proteins: NP_066409.1  
    ENSEMBL proteins: 
     ENSP00000341094  
    Reactome Protein details: P20671
    Human Recombinant Protein Products for HIST1H2AD: 
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    Cloud-Clone Corp. Proteins for HIST1H2AD 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    HIST1H2AD for ontologies           About GeneDecksing



    HIST1H2AD Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P20671

    ProtoNet protein and cluster: P20671

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1D_HUMAN, P20671
    Similarity: Belongs to the histone H2A family


    HIST1H2AD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A1D_HUMAN, P20671
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    HIST1H2AD for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H2AD About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signal transduction Activin A signaling regulation
    Signal transduction Activin A signaling regulation0.31
    Histone modification0.31
    2Packaging Of Telomere Ends
    Packaging Of Telomere Ends0.56
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    Telomere Maintenance0.56
    Amyloids0.41
    Nucleosome assembly0.46
    3Meiotic Synapsis
    Meiotic Synapsis0.70
    Meiotic Recombination0.62
    Meiosis0.70
    Chromosome Maintenance0.56
    4Alcoholism
    Alcoholism0.34
    Systemic lupus erythematosus0.34
    5Cell Cycle
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2AD
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2AD
        Signal transduction Activin A signaling regulation

    5/11        Reactome Pathways for HIST1H2AD (see all 11)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    Deposition of New CENPA-containing Nucleosomes at the Centromere
    Meiotic Recombination


    2         Kegg Pathways  (Kegg details for HIST1H2AD):
        Alcoholism
    Systemic lupus erythematosus


    HIST1H2AD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2AD

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for HIST1H2AD (P206713 ENSP000003410944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    UBCENSP000003448184STRING: ENSP00000344818
    CBX1ENSP000002256034STRING: ENSP00000225603
    CBX3ENSP000003366874STRING: ENSP00000336687
    SUPT16HENSP000002162974STRING: ENSP00000216297
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--

    HIST1H2AD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2AD (H2A1D)

    1 HMDB Compound for HIST1H2AD    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about HIST1H2AD / H2A1D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H2AD gene: 
    NM_021065.3  

    Unigene Clusters for HIST1H2AD:

    Histone cluster 1, H2ad
    Hs.626666  [show with all ESTs], Hs.679229  [show with all ESTs]
    Unigene Representative Sequences: BG437549, BE378303
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000341023(uc003ngw.3)
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    Additional mRNA sequence: 

    BC128035.1 CR541970.1 CR541999.1 

    4 DOTS entries:

    DT.100687153  DT.100017852  DT.121305467  DT.92473116 

    24/30 AceView cDNA sequences (see all 30):

    NM_021065 AI201724 AW006409 CR541999 BQ051491 CA305925 BP870844 AW135863 
    CR541970 BM007476 AI800007 BM852788 BI253496 BE378303 AI351370 BC033095 
    BC031333 NM_003530 BE796394 BX106526 AI399887 BI768916 AA779995 N35832 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2AD expression in normal human tissues (normalized intensities)      HIST1H2AD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H2AD Expression
    About this image


    HIST1H2AD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Pancreatic endoderm/endocrine precursor-like cells ( A scalable, suspension protocol...

    See HIST1H2AD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2AD

    SOURCE GeneReport for Unigene clusters: Hs.626666 Hs.679229
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H2AD gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h2ad5
    Hist1h2ak1
    histone cluster 1, H2ad5
    histone cluster 1, H2ak1
    85.9(n)1
    98.46(a)1
      13 (9.80 cM)5
    3191691  NM_178183.11  NP_835490.11 
     235744705 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    --
    98(a)
    98(a)
    (see all 5)
    possible ortholog
    many ↔ many
    (see all 5)
    GL343466.1(287338-287727)
    GL343466.1(242198-242587)


    ENSEMBL Gene Tree for HIST1H2AD (if available)
    TreeFam Gene Tree for HIST1H2AD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2AD gene
    HIST3H2A2  HIST2H2AA32  HIST2H2AB2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  HIST1H2AM2  HIST1H2AH2  
    HIST1H2AJ2  HIST2H2AA42  HIST1H2AA2  HIST1H2AE2  HIST2H2AC2  HIST1H2AB2  HIST1H2AK2  HIST1H2AL2  
    H2AFJ2  
    18/26 SIMAP similar genes for HIST1H2AD using alignment to 1 protein entry:     H2A1D_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AE    HIST1H2AG    HIST1H2AH    HIST1H2AI
    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST2H2AA3    HIST2H2AA4
    HIST3H2A    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX

    HIST1H2AD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HIST1H2AD:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv375n21CNV Loss19592680
    nsv883490CNV Loss21882294
    nsv428137CNV Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602792    OMIM disorders: --

    3 diseases for HIST1H2AD:    About MalaCards
    riddle syndrome    systemic lupus erythematosus    lupus erythematosus


    HIST1H2AD for disorders           About GeneDecksing


    Export disorders for HIST1H2AD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2AD gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with HIST1H2AD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. Genome-wide meta-analysis identifies 11 new loci for a nthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (2013)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus. (PubMed id 23084401)1 Singh G....Moore M.J. (2012)
    6. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (2012)
    7. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3013 HGNC: 4729 AceView: HIST1H3D Ensembl:ENSG00000196866 euGenes: HUgn3013
    ECgene: HIST1H2AD Kegg: 3013 H-InvDB: HIST1H2AD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2AD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H2AD gene:
    Search GeneIP for patents involving HIST1H2AD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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