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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2AD Gene

protein-coding   GIFtS: 49
GCID: GC06M026199

histone cluster 1, H2ad

(Previous names: H2A histone family, member G, histone 1, H2ad )
(Previous symbol: H2AFG)
 Explore 5 diseases affiliated with
HIST1H2AD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H2AD    

Aliases
for HIST1H2AD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H2ad1 2     Histone 1, H2ad1 2
H2AFG1 2 3 5     Histone H2A.32 3
H2A.31 2     Histone H2A/G2 3
H2A/G1     Histone H2A Type 1-D2
H2A Histone Family, Member G1 2     Histone H2AD2

External Ids:    HGNC: 47291   Entrez Gene: 30132   Ensembl: ENSG000001968667   OMIM: 6027925   UniProtKB: P206713   

Export aliases for HIST1H2AD gene to outside databases

Previous GC identifers: GC06M026256 GC06M026309 GC06M026311 GC06M026313 GC06M026315 GC06M026142


Summaries
for HIST1H2AD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H2AD:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of
pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails;
instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on
chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2A1D_HUMAN, P20671
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AD


Genomic Views
for HIST1H2AD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2AD gene promoter:
         AhR   AML1a   GCNF   GCNF-1   Olf-1   XBP-1   GCNF-2   Arnt   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HIST1H2AD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2AD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2AD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AD gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026199:  view genomic region     (about GC identifiers)

Start:
 26,199,012 bp from pter      End:
 26,199,471 bp from pter
Size:
 460 bases      Orientation:
 minus strand

Proteins
for HIST1H2AD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H2A1D_HUMAN, P20671 (See protein sequence)
Recommended Name: Histone H2A type 1-D  
Size: 130 amino acids; 14107 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=14009.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
Caution: Was originally (PubMed:2587222) thought to originate from mouse
Secondary accessions: A0PK91 P57754 Q6FGY6

Explore the universe of human proteins at neXtProt for HIST1H2AD: NX_P20671

Post-translational modifications:

  • The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    • transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by
    RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks
    (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases
    RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and
    Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates
    monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able
    to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked
    ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    • transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    • similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View neXtProt modification sites for NX_P20671

    • HIST1H2AD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066409.1  
    ENSEMBL proteins: 
     ENSP00000341094  
    Reactome Protein details: P20671
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HIST1H2AD
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    Uscn Proteins for HIST1H2AD

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005634nucleus IEA--


    HIST1H2AD for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HIST1H2AD

    Protein Domains /
    Families
    for HIST1H2AD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H2AD for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P20671

    ProtoNet protein and cluster: P20671

    1 Blocks protein family: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1D_HUMAN, P20671
    Similarity: Belongs to the histone H2A family


    Function
    for HIST1H2AD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H2A1D_HUMAN, P20671
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
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    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0046982protein heterodimerization activity IEA--


    HIST1H2AD for ontologies           About GeneDecksing



    Pathways & Interactions
    for HIST1H2AD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiotic Synapsis1.00
    		Packaging Of Telomere Ends0.54
    		Telomere clustering at the nuclear membrane0.82
    		Telomere Maintenance0.38
    		Meiosis0.70
    		Meiotic Recombination0.32
    		Chromosome Maintenance0.56
    2RSF Complex Binds the Centromere.
    		RSF Complex Binds the Centromere.1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere1.00
    		Nucleosome assembly1.00
    		Deposition of New CENPA-containing Nucleosomes at the Centromere.0.96
    3Signal transduction Activin A signaling regulation
    		Signal transduction Activin A signaling regulation1.00
    		Histone modification0.31
    		Signal transduction_Activin A signaling regulation0.96
    4Disease
    		Disease1.00
    5Cell Cycle
    		Cell Cycle1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for HIST1H2AD
        Histone modification
    Signal transduction Activin A signaling regulation


    1 GeneGo (Thomson Reuters) Pathway for HIST1H2AD
        Signal transduction Activin A signaling regulation

    5/14        Reactome Pathways for HIST1H2AD (see all 14)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Deposition of New CENPA-containing Nucleosomes at the Centromere


    1         Kegg Pathway  (Kegg details for HIST1H2AD):
        Systemic lupus erythematosus


    HIST1H2AD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2AD

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for HIST1H2AD (P206713 ENSP000003410944) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    UBCENSP000003448184STRING: ENSP00000344818
    CBX1ENSP000002256034STRING: ENSP00000225603
    CBX3ENSP000003366874STRING: ENSP00000336687
    SUPT16HENSP000002162974STRING: ENSP00000216297
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--


    HIST1H2AD for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H2AD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2AD

    1 HMDB Compound for HIST1H2AD    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about HIST1H2AD / H2A1D 

    Transcripts
    for HIST1H2AD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H2AD gene: 
    NM_021065.3  

    Unigene Cluster for HIST1H2AD:

    Histone cluster 1, H2ad
    Hs.679229  [show with all ESTs]
    Unigene Representative Sequence: DA450711
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000341023(uc003ngw.3)

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    hsa-miR-146a* hsa-miR-1276 hsa-miR-1293
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    Inhib. RNA
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    OriGene shRNA RFP: HIST1H2AD
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC093807.1 BC093809.1 BC128035.1 CR541970.1 CR541999.1 

    1 DOTS entry:

    DT.100687153 

    24/30 AceView cDNA sequences (see all 30):

    BQ051491 AI201724 CR541970 CA305925 CR541999 NM_021065 BP870844 AW006409 
    AW135863 NM_003530 BX106526 AI351370 BE378303 BM007476 BC031333 BM852788 
    BE796394 BC033095 BI253496 AI800007 CD694188 AI399887 N35832 AA779995 

    GeneLoc Exon Structure


    Expression
    for HIST1H2AD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2AD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST1H2AD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST1H2AD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2AD

    SOURCE GeneReport for Unigene cluster: Hs.679229
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    In Situ
    Assay Products:     
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    Orthologs
    for HIST1H2AD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2AD gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    HIST1H2AA6
    		 --
    		 81(a)
    59(a)
    		 possible ortholog
    possible ortholog
    		 GL343252.1(1819594-1819782)
    GL344481.1(11179-11601)
    zebrafish
    (Danio rerio)    		 Actinopterygii FP236812.26
    FP236812.16
    (see all 31)    		 --
    		 94(a)
    94(a)
    (see all 31)    		 possible ortholog
    possible ortholog
    (see all 31)    		 7(76824553-76824939)
    7(76847640-76848026)
    fruit fly
    (Drosophila melanogaster)    		 Insecta His2A:CG338326
    His2A:CG338596
    (see all 20)    		 His2A:CG33859
    (see all 20)    		 87(a)
    87(a)
    (see all 20)    		 possible ortholog
    possible ortholog
    (see all 20)    		 2L(21483244-21483812)
    2L(21528358-21528926)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 Core histone H2A/H2B/H3/H4 domain containing prote...
    		 15(a)
    		 1 → many
    		 4(7540547-7546903)


    ENSEMBL Gene Tree for HIST1H2AD (if available)
    TreeFam Gene Tree for HIST1H2AD (if available) 

    Paralogs
    for HIST1H2AD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2AD gene
    HIST3H2A2  HIST2H2AA32  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  HIST1H2AC2  HIST1H2AH2  
    HIST1H2AM2  HIST1H2AJ2  HIST2H2AA42  HIST1H2AE2  HIST2H2AC2  HIST1H2AB2  HIST1H2AK2  HIST1H2AL2  
    H2AFJ2  
    18/26 SIMAP similar genes for HIST1H2AD using alignment to 1 protein entry:     H2A1D_HUMAN(see all similar genes):
    HIST1H2AB    HIST1H2AC    HIST1H2AE    HIST1H2AG    HIST1H2AH    HIST1H2AI
    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST2H2AA3    HIST2H2AA4
    HIST3H2A    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX

    HIST1H2AD for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H2AD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 NCBI SNPs in HIST1H2AD are shown (see all 87)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1437988181,2
    		--26198562(+) TTTTTG/TGGGTT 3 -- int1 ds5001 us2k10--------
    rs1121225931,2
    		--26198653(+) CTCCGG/TGGTTC 3 -- int1 us2k1 ds50011Minor allele frequency- T:0.50CSA 2
    rs1882810351,2
    		--26198709(+) CGCGCA/GCCACC 3 -- int1 us2k1 ds50010--------
    rs1161038091,2
    		F,--26198728(+) CAAATT/ATTTTT 3 -- ds5001 us2k1 int11Minor allele frequency- A:0.02WA 118
    rs1822866361,2
    		--26198781(+) GTCCTA/GGAACT 3 -- int1 us2k1 ds50010--------
    rs21795171,2
    		C,F,A,H,--26198845(+) GTAAGC/GAACCG 3 -- int1 us2k1 ds500111Minor allele frequency- G:0.39WA NA CSA EA 373
    rs8067921,2
    		C,F,O,H,--26198916(+) GATTCA/GGTGTT 3 -- us2k1 ds5001 int124Minor allele frequency- G:0.16MN NS EA NA WA CSA 2594
    rs1856292611,2
    		--26198924(+) GTTAAA/GAACAC 3 -- ds5001 us2k1 int10--------
    rs787713891,2
    		F,--26198943(+) AAATGG/CAAAAA 3 -- int1 ds5001 us2k11Minor allele frequency- C:0.02NA 120
    rs1410195591,2
    		--26198955(+) TATTAA/GAGAAA 3 -- ds5001 us2k1 int10--------

    HapMap Linkage Disequilibrium report for HIST1H2AD (26199012 - 26199471 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HIST1H2AD
         1 CNV: 51865

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    Disorders / Diseases
    for HIST1H2AD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H2AD for disorders           About GeneDecksing

    OMIM gene information: 602792    OMIM disorders: --

    5 diseases for HIST1H2AD:    About MalaCards
    x inactivation    riddle syndrome    systemic lupus erythematosus    lupus erythematosus
    immunodeficiency


    Export disorders for HIST1H2AD gene to outside databases

    Publications
    for HIST1H2AD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2AD gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with HIST1H2AD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 2, 3 Albig W.... Doenecke D. (1997)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase. (PubMed id 22713238)2 Gatti M.... Penengo L. (2012)
    5. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA Damage signaling. (PubMed id 22980979)2 Mattiroli F.... Sixma T.K. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. (PubMed id 21925322)2 Tan M.... Zhao Y. (2011)
    8. Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. (PubMed id 20639865)1 Xu G....Jaffrey S.R. (2010)

    External Searches for HIST1H2AD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H2AD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3013 HGNC: 4729 AceView: HIST1H3D Ensembl:ENSG00000196866 euGenes: HUgn3013
    ECgene: HIST1H2AD Kegg: 3013 H-InvDB: HIST1H2AD

    Other Databases showing HIST1H2AD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H2AD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2AD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H2AD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H2AD gene:
    Search GeneIP for patents involving HIST1H2AD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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