Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST1H2AC Gene

Aliases for HIST1H2AC Gene

  • Histone Cluster 1, H2ac 2 3 5
  • H2A Histone Family, Member L 2 3
  • Histone 1, H2ac 2 3
  • Histone H2A/L 3 4
  • H2AFL 3 4
  • Histone H2AC 3
  • DJ221C16.4 3
  • H2A/L 3

External Ids for HIST1H2AC Gene

Previous HGNC Symbols for HIST1H2AC Gene

  • H2AFL

Previous GeneCards Identifiers for HIST1H2AC Gene

  • GC06P026182
  • GC06P026232
  • GC06P026125
  • GC06P026067
  • GC06P026126
  • GC06P026131
  • GC06P026132
  • GC06P026134
  • GC06P026136
  • GC06P026138
  • GC06P026140
  • GC06P026143
  • GC06P026146

Summaries for HIST1H2AC Gene

Entrez Gene Summary for HIST1H2AC Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2AC Gene

HIST1H2AC (Histone Cluster 1, H2ac) is a Protein Coding gene. Among its related pathways are Chromatin organization and Packaging Of Telomere Ends. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2AM.

UniProtKB/Swiss-Prot for HIST1H2AC Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2AC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AC Gene

Genomics for HIST1H2AC Gene

Regulatory Elements for HIST1H2AC Gene

Enhancers for HIST1H2AC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIST1H2AC on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H2AC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H2AC on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H2AC Gene

26,124,145 bp from pter
26,139,116 bp from pter
14,972 bases
Plus strand

Genomic View for HIST1H2AC Gene

Genes around HIST1H2AC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2AC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2AC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AC Gene

Proteins for HIST1H2AC Gene

  • Protein details for HIST1H2AC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone H2A type 1-C
    Protein Accession:
    Secondary Accessions:
    • B2R4F7
    • O00775
    • O00776
    • O00777
    • O00778
    • Q540R1

    Protein attributes for HIST1H2AC Gene

    130 amino acids
    Molecular mass:
    14105 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for HIST1H2AC Gene

Proteomics data for HIST1H2AC Gene at MOPED

Post-translational modifications for HIST1H2AC Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys 14 and Lys 16
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AC Gene

Domains & Families for HIST1H2AC Gene

Gene Families for HIST1H2AC Gene

Protein Domains for HIST1H2AC Gene

Suggested Antigen Peptide Sequences for HIST1H2AC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the histone H2A family.
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AC: view

Function for HIST1H2AC Gene

Molecular function for HIST1H2AC Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
genes like me logo Genes that share phenotypes with HIST1H2AC: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AC Gene

Localization for HIST1H2AC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AC Gene

Nucleus. Chromosome.

Subcellular locations from

Jensen Localization Image for HIST1H2AC Gene COMPARTMENTS Subcellular localization image for HIST1H2AC gene
Compartment Confidence
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HIST1H2AC Gene

Pathways & Interactions for HIST1H2AC Gene

SuperPathways for HIST1H2AC Gene

Superpath Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 Cellular Senescence
3 Chromosome Maintenance
4 Packaging Of Telomere Ends
5 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with HIST1H2AC: view

Gene Ontology (GO) - Biological Process for HIST1H2AC Gene


No data available for SIGNOR curated interactions for HIST1H2AC Gene

Drugs & Compounds for HIST1H2AC Gene

(1) Drugs for HIST1H2AC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with HIST1H2AC: view

Transcripts for HIST1H2AC Gene

mRNA/cDNA for HIST1H2AC Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(335) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AC Gene

Histone cluster 1, H2ac:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1: -
SP3: -
SP4: - -

Relevant External Links for HIST1H2AC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIST1H2AC Gene

mRNA expression in normal human tissues for HIST1H2AC Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2AC Gene

This gene is overexpressed in Whole Blood (x12.8).

Protein differential expression in normal tissues from HIPED for HIST1H2AC Gene

This gene is overexpressed in Saliva (37.3) and Heart (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H2AC Gene

SOURCE GeneReport for Unigene cluster for HIST1H2AC Gene Hs.484950

genes like me logo Genes that share expression patterns with HIST1H2AC: view

Protein tissue co-expression partners for HIST1H2AC Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST1H2AC Gene

Orthologs for HIST1H2AC Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H2AC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HIST1H2AC 35
  • 85.64 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia LOC488268 35
  • 89.23 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Hist1h2ao 35
  • 87.69 (n)
  • 98.46 (a)
Hist1h2ao 16
Hist1h2al 36
  • 98 (a)
(Pan troglodytes)
Mammalia HIST1H2AC 35
  • 99.49 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hist3h2a 35
  • 86.15 (n)
  • 99.23 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
-- 36
  • 91 (a)
-- 36
  • 95 (a)
-- 36
  • 95 (a)
-- 36
  • 88 (a)
-- 36
  • 91 (a)
-- 36
  • 88 (a)
(Gallus gallus)
Aves H2A-VII 36
  • 98 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
Species with no ortholog for HIST1H2AC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AC Gene

Gene Tree for HIST1H2AC (if available)
Gene Tree for HIST1H2AC (if available)

Paralogs for HIST1H2AC Gene

genes like me logo Genes that share paralogs with HIST1H2AC: view

Variants for HIST1H2AC Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1773284 -- 26,122,225(+) TTTCC(A/C)AGGTG upstream-variant-2KB
rs1773285 -- 26,122,471(+) ACCAT(G/T)AGTAA upstream-variant-2KB
rs198823 -- 26,122,705(+) AACTT(G/T)TCTGC upstream-variant-2KB
rs198824 -- 26,122,555(+) GGAGA(C/T)ACAGT upstream-variant-2KB
rs198825 -- 26,122,274(+) GTTAA(A/G)TAACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AC Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914

Variation tolerance for HIST1H2AC Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.55% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HIST1H2AC Gene

Disorders for HIST1H2AC Gene

Relevant External Links for HIST1H2AC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HIST1H2AC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AC Gene

Publications for HIST1H2AC Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. (PMID: 24740910) Zheng W.W. … Yang X.M. (Stem Cells 2014) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for HIST1H2AC Gene

Sources for HIST1H2AC Gene