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Aliases for HIST1H2AC Gene

Aliases for HIST1H2AC Gene

  • Histone Cluster 1 H2A Family Member C 2 3 5
  • H2A Histone Family, Member L 2 3
  • Histone Cluster 1, H2ac 2 3
  • Histone 1, H2ac 2 3
  • Histone H2A/L 3 4
  • H2AFL 3 4
  • Histone H2A Type 1-C 3
  • Histone H2AC 3
  • DJ221C16.4 3
  • H2A/L 3

External Ids for HIST1H2AC Gene

Previous HGNC Symbols for HIST1H2AC Gene

  • H2AFL

Previous GeneCards Identifiers for HIST1H2AC Gene

  • GC06P026182
  • GC06P026232
  • GC06P026125
  • GC06P026067
  • GC06P026126
  • GC06P026131
  • GC06P026132
  • GC06P026134
  • GC06P026136
  • GC06P026138
  • GC06P026140
  • GC06P026143
  • GC06P026146
  • GC06P026155
  • GC06P026408

Summaries for HIST1H2AC Gene

Entrez Gene Summary for HIST1H2AC Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2AC Gene

HIST1H2AC (Histone Cluster 1 H2A Family Member C) is a Protein Coding gene. Among its related pathways are Mitotic Prophase and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot for HIST1H2AC Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2AC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AC Gene

Genomics for HIST1H2AC Gene

Regulatory Elements for HIST1H2AC Gene

Enhancers for HIST1H2AC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F026120 1.6 FANTOM5 ENCODE 2.8 -0.2 -171 7.8 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 SSRP1 ABT1 ENSG00000272462 HMGN4 HIST1H2APS5 ZNF322 HIST1H2APS4 HIST1H2BA HIST1H2BPS1 ENSG00000271071 LOC101928663
GH06F026520 1.6 FANTOM5 ENCODE 1.3 +397.6 397616 3.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZFP41 MEF2D HMGN4 ABT1 LOC102724851 ZNF391 BTN1A1 HIST1H2APS4 HIST1H3G BTN3A3 BTN2A1 BTN3A2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST1H2AC on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H2AC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001213990 855 5201 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21

Genomic Location for HIST1H2AC Gene

Chromosome:
6
Start:
26,124,145 bp from pter
End:
26,139,116 bp from pter
Size:
14,972 bases
Orientation:
Plus strand

Genomic View for HIST1H2AC Gene

Genes around HIST1H2AC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2AC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2AC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AC Gene

Proteins for HIST1H2AC Gene

  • Protein details for HIST1H2AC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93077-H2A1C_HUMAN
    Recommended name:
    Histone H2A type 1-C
    Protein Accession:
    Q93077
    Secondary Accessions:
    • B2R4F7
    • O00775
    • O00776
    • O00777
    • O00778
    • Q540R1

    Protein attributes for HIST1H2AC Gene

    Size:
    130 amino acids
    Molecular mass:
    14105 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

neXtProt entry for HIST1H2AC Gene

Post-translational modifications for HIST1H2AC Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at Lys 14 and Lys 16
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AC Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AC Gene

Domains & Families for HIST1H2AC Gene

Gene Families for HIST1H2AC Gene

Protein Domains for HIST1H2AC Gene

Suggested Antigen Peptide Sequences for HIST1H2AC Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93077

UniProtKB/Swiss-Prot:

H2A1C_HUMAN :
  • Belongs to the histone H2A family.
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AC: view

Function for HIST1H2AC Gene

Molecular function for HIST1H2AC Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for HIST1H2AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IBA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2AC: view
genes like me logo Genes that share phenotypes with HIST1H2AC: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AC Gene

Localization for HIST1H2AC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AC Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H2AC gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IDA 16319397
GO:0005694 chromosome IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with HIST1H2AC: view

Pathways & Interactions for HIST1H2AC Gene

SuperPathways for HIST1H2AC Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 Cellular Senescence
3 Chromosome Maintenance
4 Cell Cycle, Mitotic
.60
5 Chromatin organization
genes like me logo Genes that share pathways with HIST1H2AC: view

Gene Ontology (GO) - Biological Process for HIST1H2AC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006342 chromatin silencing IBA --
GO:0008285 negative regulation of cell proliferation IMP 23956221
genes like me logo Genes that share ontologies with HIST1H2AC: view

No data available for SIGNOR curated interactions for HIST1H2AC Gene

Drugs & Compounds for HIST1H2AC Gene

(1) Drugs for HIST1H2AC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with HIST1H2AC: view

Transcripts for HIST1H2AC Gene

mRNA/cDNA for HIST1H2AC Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(335) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AC Gene

Histone cluster 1, H2ac:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for HIST1H2AC Gene

GeneLoc Exon Structure for
HIST1H2AC
ECgene alternative splicing isoforms for
HIST1H2AC

Expression for HIST1H2AC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HIST1H2AC Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2AC Gene

This gene is overexpressed in Whole Blood (x12.8).

Protein differential expression in normal tissues from HIPED for HIST1H2AC Gene

This gene is overexpressed in Saliva (37.3) and Heart (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H2AC Gene



Protein tissue co-expression partners for HIST1H2AC Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST1H2AC Gene:

HIST1H2AC

SOURCE GeneReport for Unigene cluster for HIST1H2AC Gene:

Hs.484950
genes like me logo Genes that share expression patterns with HIST1H2AC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIST1H2AC Gene

Orthologs for HIST1H2AC Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H2AC Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HIST1H2AC 35
  • 100 (a)
OneToOne
LOC488268 34
  • 89.23 (n)
chimpanzee
(Pan troglodytes)
Mammalia HIST1H2AC 34 35
  • 99.49 (n)
mouse
(Mus musculus)
Mammalia Hist1h2al 35
  • 98 (a)
ManyToMany
Hist1h2ao 34 16
  • 87.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
ManyToMany
-- 35
  • 95 (a)
ManyToMany
-- 35
  • 95 (a)
ManyToMany
-- 35
  • 91 (a)
ManyToMany
-- 35
  • 91 (a)
ManyToMany
-- 35
  • 88 (a)
ManyToMany
-- 35
  • 88 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Hist3h2a 34
  • 86.15 (n)
cow
(Bos Taurus)
Mammalia HIST1H2AC 34 35
  • 85.64 (n)
chicken
(Gallus gallus)
Aves H2A-VII 35
  • 98 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
OneToMany
Species where no ortholog for HIST1H2AC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AC Gene

ENSEMBL:
Gene Tree for HIST1H2AC (if available)
TreeFam:
Gene Tree for HIST1H2AC (if available)

Paralogs for HIST1H2AC Gene

Variants for HIST1H2AC Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AC Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs111229486 -- 26,123,071(+) AAATC(A/C)GAGTC downstream-variant-500B, upstream-variant-2KB
rs111838595 -- 26,125,166(+) GAGTT(G/T)AAAGG downstream-variant-500B, upstream-variant-2KB
rs111914406 -- 26,123,931(+) CGAAA(A/G)TAAAG upstream-variant-2KB
rs112243193 -- 26,122,255(+) AAGAT(A/C)ACACA upstream-variant-2KB
rs112692109 -- 26,124,214(+) TTTGG(C/T)GATTT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AC Gene

Variant ID Type Subtype PubMed ID
nsv970082 CNV duplication 23825009
nsv428137 CNV loss 18775914
nsv1023453 CNV gain 25217958
esv3608393 CNV gain 21293372
dgv5926n100 CNV gain 25217958

Variation tolerance for HIST1H2AC Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2AC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H2AC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AC Gene

Disorders for HIST1H2AC Gene

Relevant External Links for HIST1H2AC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2AC

No disorders were found for HIST1H2AC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AC Gene

Publications for HIST1H2AC Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  2. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 2 3 4 64
  3. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne M.T. II … Kelleher N.L. (J. Proteome Res. 2006) 3 4 64
  4. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PMID: 16702407) Bergink S. … Dantuma N.P. (Genes Dev. 2006) 3 4 64
  5. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PMID: 15823041) Hagiwara T. … Yamada M. (Biochemistry 2005) 3 4 64

Products for HIST1H2AC Gene

Sources for HIST1H2AC Gene

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