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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2AB Gene

protein-coding   GIFtS: 53
GCID: GC06M026033

histone cluster 1, H2ab

(Previous names: H2A histone family, member M, histone 1, H2ab )
(Previous symbol: H2AFM)
 Explore 6 diseases affiliated with
HIST1H2AB via our new
 Human Malady Compendium 
Biological research products
for HIST1H2AB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Histone Cluster 1, H2ab1 2     Histone H2A/M2 3
H2AFM1 2 3 5     Histone H2A Type 1-B/E2
H2A/M1     H2AFA3
H2A Histone Family, Member M1 2     Histone H2A.23
Histone 1, H2ab1 2     Histone H2A/A3

External Ids:    HGNC: 47341   Entrez Gene: 83352   Ensembl: ENSG000001372597   OMIM: 6027955   UniProtKB: P049083   

Export aliases for HIST1H2AB gene to outside databases

Previous GC identifers: GC06M026090 GC06M026141 GC06M025976


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H2AB:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of
pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails;
instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on
chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
post-translational modifications of histones, also called histone code, and nucleosome remodeling

Gene Wiki entry for HIST1H2AB


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2AB gene promoter:
         AhR   NF-1   NF-1/L   FOXO4   ZID   Pax-4a   E47   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H2AB promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2AB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2AB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H2AB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026033:  view genomic region     (about GC identifiers)

Start:
26,033,320 bp from pter      End:
26,033,796 bp from pter
Size:
477 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908 (See protein sequence)
Recommended Name: Histone H2A type 1-B/E  
Size: 130 amino acids; 14135 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome
Mass spectrometry: Mass=14037.9; Method=Electrospray; Range=2-130; Note=Monoisotopic with N-acetylserine;
Source=PubMed:16457589;
6/17 PDB 3D structures from and Proteopedia for HIST1H2AB (see all 17):
2CV5 (3D)        3A6N (3D)        3AFA (3D)        3AN2 (3D)        3AV1 (3D)        3AV2 (3D)    
Secondary accessions: P28001 Q76P63

Explore the universe of human proteins at neXtProt for HIST1H2AB: NX_P04908

Post-translational modifications:

  • The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)1
  • Deiminated on Arg-4 in granulocytes upon calcium entry1
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
  • transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by
    RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks
    (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases
    RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and
    Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates
    monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able
    to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked
    ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events1
  • Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
  • transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK11
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
  • similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
  • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P04908

  • HIST1H2AB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003504.2  
    ENSEMBL proteins: 
     ENSP00000259791  
    Reactome Protein details: P04908
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H2AB

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005634nucleus IEA--


    HIST1H2AB for ontologies           About GeneDecksing



    HIST1H2AB Antibody Products: 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HIST1H2AB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry P04908

    ProtoNet protein and cluster: P04908

    1 Blocks protein family: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908
    Similarity: Belongs to the histone H2A family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: H2A1B_HUMAN, P04908
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to
    the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription
    regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of
    post-translational modifications of histones, also called histone code, and nucleosome remodeling

    miRNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS6647026
    GO:0046982protein heterodimerization activity IEA--


    HIST1H2AB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HIST1H2AB:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Systemic lupus erythematosus
    Systemic lupus erythematosus1.00
    2Ubiquitinated Orc1 is degraded by the proteasome
    Proteasome Degradation0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for HIST1H2AB 
        Proteasome Degradation

    5/14        Reactome Pathways for HIST1H2AB (see all 14)
        Telomere Maintenance
    Nucleosome assembly
    Cell Cycle
    RSF Complex Binds the Centromere.
    Deposition of New CENPA-containing Nucleosomes at the Centromere


    1         Kegg Pathway  (Kegg details for HIST1H2AB):
        Systemic lupus erythematosus


    HIST1H2AB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2AB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/165 Interacting proteins for HIST1H2AB (P049082, 3 ENSP000002597914) via UniProtKB, MINT, STRING, and/or I2D (see all 165)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--


    HIST1H2AB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2AB

    1 HMDB Compound for HIST1H2AB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about HIST1H2AB / H2A1B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H2AB gene: 
    NM_003513.2  

    Unigene Cluster for HIST1H2AB:

    Histone cluster 1, H2ab
    Hs.248174  [show with all ESTs]
    Unigene Representative Sequence: CK130254
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000259791(uc003nft.1)

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    hsa-miR-146a* hsa-miR-1276
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    Additional cDNA sequence: 

    AK311785.1 BC125140.1 

    1 DOTS entry:

    DT.91859377 

    9 AceView cDNA sequences:

    NM_003513 CK130258 CK130259 CK130278 CK130255 CK130256 CK130257 CF272106 
    CK130253 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2AB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACTGCTGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HIST1H2AB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H2AB

    SOURCE GeneReport for Unigene cluster: Hs.248174
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2AB gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    HIST1H2AA6
    --
    81(a)
    59(a)
    possible ortholog
    possible ortholog
    GL343252.1(1819594-1819782)
    GL344481.1(11179-11601)
    zebrafish
    (Danio rerio)
    Actinopterygii CR354435.56
    CR354435.76
    (see all 31)
    --
    94(a)
    94(a)
    (see all 31)
    possible ortholog
    possible ortholog
    (see all 31)
    25(37377991-37378377)
    25(37403772-37404158)
    fruit fly
    (Drosophila melanogaster)
    Insecta His2A:CG338236
    His2A:CG338416
    (see all 20)
    His2A:CG33841
    (see all 20)
    87(a)
    87(a)
    (see all 20)
    possible ortholog
    possible ortholog
    (see all 20)
    2L(21468115-21468683)
    2L(21498485-21499053)
    rice
    (Oryza sativa)
    Liliopsida --
    Core histone H2A/H2B/H3/H4 domain containing prote...
    15(a)
    1 → many
    4(7540547-7546903)


    ENSEMBL Gene Tree for HIST1H2AB (if available)
    TreeFam Gene Tree for HIST1H2AB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2AB gene
    HIST1H2AE1 2  HIST3H2A2  HIST1H2AD2  HIST2H2AA32  HIST2H2AB2  H2AFX2  HIST1H2AI2  HIST1H2AG2  
    HIST1H2AC2  HIST1H2AH2  HIST1H2AM2  HIST1H2AJ2  HIST2H2AA42  HIST2H2AC2  HIST1H2AK2  HIST1H2AL2  
    H2AFJ2  
    18/26 SIMAP similar genes for HIST1H2AB using alignment to 2 protein entries:     H2A1B_HUMAN (see all proteins) (see all similar genes):
    HIST1H2AC    HIST1H2AD    HIST1H2AE    HIST1H2AG    HIST1H2AH    HIST1H2AI
    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM    HIST2H2AA3    HIST2H2AA4
    HIST3H2A    H2AFJ    HIST1H2AA    HIST2H2AB    HIST2H2AC    H2AFX

    HIST1H2AB for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HIST1H2AB
    PGOHUM00000243518


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/95 NCBI SNPs in HIST1H2AB are shown (see all 95    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1814896761,2
    --26032832(+) TGTTAC/TCACGC 2 -- us2k1 ds50010--------
    rs64567081,2
    C,F,A,--26032847(+) GCACTC/GCAGCT 2 -- ds5001 us2k19Minor allele frequency- G:0.39NA WA CSA EA 369
    rs119611431,2
    C,F,H,--26032873(+) CTCCAC/TCCCAA 2 -- us2k1 ds50015Minor allele frequency- T:0.12NA WA EA 362
    rs1437033341,2
    --26032946(+) TCAGTA/GGTAAT 2 -- us2k1 ds50010--------
    rs1861243361,2
    --26032965(+) TCTCAA/GTTGTG 2 -- us2k1 ds50010--------
    rs759757901,2
    C,--26033063(+) AGGAAT/AGCACT 2 -- us2k1 ds50012Minor allele frequency- A:0.10CSA WA 120
    rs1175128651,2
    C,F,--26033127(+) AACGCG/AAATCA 2 -- us2k1 ds50011Minor allele frequency- A:0.06EA 120
    rs756683961,2
    C,F,--26033138(+) CCCCTG/ATAAAC 2 -- ds5001 us2k12Minor allele frequency- A:0.03WA EA 238
    rs1908272191,2
    --26033216(+) CTGCAA/GGACAA 2 -- us2k1 ds50010--------
    rs1826506731,2
    --26033231(+) CTAAAA/GGTGCC 2 -- us2k1 ds50010--------

    HapMap Linkage Disequilibrium report for HIST1H2AB (26033320 - 26033796 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H2AB: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HIST1H2AB for disorders           About GeneDecksing

    OMIM gene information: 602795    OMIM disorders: --

    6 diseases for HIST1H2AB:    About MalaCards
    riddle syndrome    systemic lupus erythematosus    lupus erythematosus    cockayne syndrome
    hemochromatosis    immunodeficiency

    Human Genome Epidemiology (HuGE) Navigator: HIST1H2AB (1 document)

    Export disorders for HIST1H2AB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2AB gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with HIST1H2AB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. The human histone gene cluster at the D6S105 locus. (PubMed id 9439656)1, 2, 3 Albig W. and Doenecke D. (1997)
    3. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (2006)
    4. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (2005)
    5. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    6. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (2004)
    7. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (2004)
    8. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)1, 2 Aihara H.... Ito T. (2004)
    9. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 3 Albig W.... Doenecke D. (1997)
    10. The primary structure and expression of four cloned human histone genes. (PubMed id 6647026)1, 2 Zhong R.... Heintz N. (1983)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8335 HGNC: 4734 AceView: HIST1H2AB Ensembl:ENSG00000137259 euGenes: HUgn8335
    ECgene: HIST1H2AB Kegg: 8335 H-InvDB: HIST1H2AB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2AB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H2AB gene:
    Search GeneIP for patents involving HIST1H2AB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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