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Aliases for HIST1H2AB Gene

Aliases for HIST1H2AB Gene

  • Histone Cluster 1 H2A Family Member B 2 3 5
  • H2A Histone Family, Member M 2 3
  • Histone Cluster 1, H2ab 2 3
  • Histone 1, H2ab 2 3
  • Histone H2A/M 3 4
  • H2AFM 3 4
  • Histone H2A Type 1-B/E 3
  • HIST1H2AB HIST1H2AE 4
  • Histone H2A.2 4
  • Histone H2A/A 4
  • H2A/M 3
  • H2AFA 4

External Ids for HIST1H2AB Gene

Previous HGNC Symbols for HIST1H2AB Gene

  • H2AFM

Previous GeneCards Identifiers for HIST1H2AB Gene

  • GC06M026090
  • GC06M026141
  • GC06M025976

Summaries for HIST1H2AB Gene

Entrez Gene Summary for HIST1H2AB Gene

  • Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H2AB Gene

HIST1H2AB (Histone Cluster 1 H2A Family Member B) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Meiosis. GO annotations related to this gene include sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST1H2AE.

UniProtKB/Swiss-Prot for HIST1H2AB Gene

  • Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Wiki entry for HIST1H2AB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H2AB Gene

Genomics for HIST1H2AB Gene

Regulatory Elements for HIST1H2AB Gene

Enhancers for HIST1H2AB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G025535 1 FANTOM5 2.9 +498.0 498018 0.0 PKNOX1 ATF1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 SMARCB1 SMARCA4 LOC101928663 RPL21P68 CARMIL1 LOC100533655 CMAHP HIST1H4A HIST1H3B HIST1H4B HIST1H2AB HIST1H3A
GH06G026120 2.1 FANTOM5 Ensembl ENCODE dbSUPER 1.3 -90.4 -90407 7.8 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 SSRP1 ABT1 ENSG00000272462 HMGN4 NUP50P2 ZNF322 HFE BTN3A2 HIST1H1C HIST1H2APS5 BTN3A1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST1H2AB on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H2AB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000194973 968 3201 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3

Genomic Location for HIST1H2AB Gene

Chromosome:
6
Start:
26,033,092 bp from pter
End:
26,033,568 bp from pter
Size:
477 bases
Orientation:
Minus strand

Genomic View for HIST1H2AB Gene

Genes around HIST1H2AB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H2AB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H2AB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H2AB Gene

Proteins for HIST1H2AB Gene

  • Protein details for HIST1H2AB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04908-H2A1B_HUMAN
    Recommended name:
    Histone H2A type 1-B/E
    Protein Accession:
    P04908
    Secondary Accessions:
    • P28001
    • Q76P63

    Protein attributes for HIST1H2AB Gene

    Size:
    130 amino acids
    Molecular mass:
    14135 Da
    Quaternary structure:
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    • The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Three dimensional structures from OCA and Proteopedia for HIST1H2AB Gene

neXtProt entry for HIST1H2AB Gene

Post-translational modifications for HIST1H2AB Gene

  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • Deiminated on Arg-4 in granulocytes upon calcium entry.
  • Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239).
  • Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM27 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of Lys-27 of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM27 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through Lys-63 linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and Lys-63-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend Lys-63-linked ubiquitin chains in vitro. H2AK119Ub and ionizing radiation-induced Lys-63-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events.
  • Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription.
  • Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage.
  • Ubiquitination at isoforms=14 and posLast=1616
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H2AB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H2AB Gene

Domains & Families for HIST1H2AB Gene

Gene Families for HIST1H2AB Gene

Protein Domains for HIST1H2AB Gene

Suggested Antigen Peptide Sequences for HIST1H2AB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P04908

UniProtKB/Swiss-Prot:

H2A1B_HUMAN :
  • Belongs to the histone H2A family.
Family:
  • Belongs to the histone H2A family.
genes like me logo Genes that share domains with HIST1H2AB: view

Function for HIST1H2AB Gene

Molecular function for HIST1H2AB Gene

UniProtKB/Swiss-Prot Function:
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Ontology (GO) - Molecular Function for HIST1H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 6647026
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with HIST1H2AB: view
genes like me logo Genes that share phenotypes with HIST1H2AB: view

Animal Model Products

miRNA for HIST1H2AB Gene

miRTarBase miRNAs that target HIST1H2AB

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H2AB Gene

Localization for HIST1H2AB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H2AB Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H2AB gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HIST1H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IBA --
GO:0005634 nucleus IDA 16319397
GO:0005694 chromosome IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with HIST1H2AB: view

Pathways & Interactions for HIST1H2AB Gene

SuperPathways for HIST1H2AB Gene

SuperPathway Contained pathways
1 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
2 Cellular Senescence
3 Chromosome Maintenance
4 Cell Cycle, Mitotic
.60
5 Chromatin organization
genes like me logo Genes that share pathways with HIST1H2AB: view

Gene Ontology (GO) - Biological Process for HIST1H2AB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006342 chromatin silencing IBA --
GO:0008285 negative regulation of cell proliferation IMP 23956221
genes like me logo Genes that share ontologies with HIST1H2AB: view

No data available for SIGNOR curated interactions for HIST1H2AB Gene

Drugs & Compounds for HIST1H2AB Gene

(1) Drugs for HIST1H2AB Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with HIST1H2AB: view

Transcripts for HIST1H2AB Gene

mRNA/cDNA for HIST1H2AB Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H2AB Gene

Histone cluster 1, H2ab:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H2AB Gene

No ASD Table

Relevant External Links for HIST1H2AB Gene

GeneLoc Exon Structure for
HIST1H2AB
ECgene alternative splicing isoforms for
HIST1H2AB

Expression for HIST1H2AB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H2AB Gene

mRNA differential expression in normal tissues according to GTEx for HIST1H2AB Gene

This gene is overexpressed in Testis (x10.1) and Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for HIST1H2AB Gene

This gene is overexpressed in Monocytes (17.3), Neutrophil (13.2), Adipocyte (10.7), Blymphocyte (10.3), and Tlymphocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIST1H2AB Gene



Protein tissue co-expression partners for HIST1H2AB Gene

NURSA nuclear receptor signaling pathways regulating expression of HIST1H2AB Gene:

HIST1H2AB

SOURCE GeneReport for Unigene cluster for HIST1H2AB Gene:

Hs.248174

Evidence on tissue expression from TISSUES for HIST1H2AB Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with HIST1H2AB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H2AB Gene

Orthologs for HIST1H2AB Gene

This gene was present in the common ancestor of mammals.

Orthologs for HIST1H2AB Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hist1h2ag 34 16
  • 85.9 (n)
cow
(Bos Taurus)
Mammalia LOC524236 34
  • 84.87 (n)
chimpanzee
(Pan troglodytes)
Mammalia LOC471884 34
  • 83.08 (n)
rat
(Rattus norvegicus)
Mammalia Hist1h2ak 34
  • 82.82 (n)
Species where no ortholog for HIST1H2AB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIST1H2AB Gene

ENSEMBL:
Gene Tree for HIST1H2AB (if available)
TreeFam:
Gene Tree for HIST1H2AB (if available)

Paralogs for HIST1H2AB Gene

Variants for HIST1H2AB Gene

Sequence variations from dbSNP and Humsavar for HIST1H2AB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000232478 -- 26,032,723(+) GGTAA(-/TG)TGTGT downstream-variant-500B, upstream-variant-2KB
rs1000820399 -- 26,033,566(+) CCAGA(C/T)ATAAC upstream-variant-2KB, reference, missense
rs1001440888 -- 26,034,690(+) AAGAA(A/G)TCAGC upstream-variant-2KB
rs1001822488 -- 26,034,700(+) CGTAA(C/T)AAAGT upstream-variant-2KB
rs1002441844 -- 26,033,590(+) GGAAA(A/G)TCGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H2AB Gene

Variant ID Type Subtype PubMed ID
dgv5926n100 CNV gain 25217958
esv3608392 CNV gain 21293372
nsv1023453 CNV gain 25217958
nsv1026692 CNV loss 25217958
nsv428137 CNV loss 18775914
nsv509122 CNV insertion 20534489

Variation tolerance for HIST1H2AB Gene

Residual Variation Intolerance Score: 31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H2AB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H2AB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H2AB Gene

Disorders for HIST1H2AB Gene

Relevant External Links for HIST1H2AB

Genetic Association Database (GAD)
HIST1H2AB
Human Genome Epidemiology (HuGE) Navigator
HIST1H2AB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H2AB

No disorders were found for HIST1H2AB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H2AB Gene

Publications for HIST1H2AB Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  2. The human histone gene cluster at the D6S105 locus. (PMID: 9439656) Albig W. … Doenecke D. (Hum. Genet. 1997) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Precise characterization of human histones in the H2A gene family by top down mass spectrometry. (PMID: 16457589) Boyne M.T. II … Kelleher N.L. (J. Proteome Res. 2006) 3 4 64
  5. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PMID: 16702407) Bergink S. … Dantuma N.P. (Genes Dev. 2006) 3 4 64

Products for HIST1H2AB Gene

Sources for HIST1H2AB Gene

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