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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H2AA Gene

protein-coding   GIFtS: 50
GCID: GC06M025726

Histone Cluster 1, H2aa

(Previous names: H2A histone family, member R, histone 1, H2aa)
  3 related diseases
at
MalaCards
 

Aliases
for HIST1H2AA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Histone Cluster 1, H2aa1 2     H2AA2 5
H2AFR2 3 5     bA317E16.22
H2A Histone Family, Member R1 2     Histone H2A Type 1-A2
Histone 1, H2aa1 2     HISTH2AA5
Histone H2A/R2 3     

External Ids:    HGNC: 187291   Entrez Gene: 2216132   Ensembl: ENSG000001645087   OMIM: 6134995   UniProtKB: Q96QV63   

Export aliases for HIST1H2AA gene to outside databases

Previous GC identifers: GC06M025784 GC06M025834 GC06M025669


Summaries
for HIST1H2AA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H2AA Gene:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in
eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs
of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the
interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin
structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene
contain a palindromic termination element. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2AA Gene: 
HIST1H2AA (histone cluster 1, H2aa) is a protein-coding gene. Diseases associated with HIST1H2AA include riddle syndrome, and systemic lupus erythematosus, and among its related super-pathways are Systemic lupus erythematosus. GO annotations related to this gene include DNA binding and protein heterodimerization activity. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A1A_HUMAN, Q96QV6
Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
regulated via a complex set of post-translational modifications of histones, also called histone code, and
nucleosome remodeling

Gene Wiki entry for HIST1H2AA Gene


Genomic Views
for HIST1H2AA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H2AA gene promoter:
         Max   E2F-1   E2F   POU2F1a   ZID   TGIF   Pax-4a   c-Myc   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H2AA promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H2AA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H2AA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.2   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.2

HIST1H2AA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M025726:  view genomic region     (about GC identifiers)

Start:
 25,726,291 bp from pter      End:
 25,726,790 bp from pter
Size:
 500 bases      Orientation:
 minus strand

Proteins
for HIST1H2AA gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: H2A1A_HUMAN, Q96QV6 (See protein sequence)
Recommended Name: Histone H2A type 1-A  
Size: 131 amino acids; 14234 Da
Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one
H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA
Subcellular location: Nucleus. Chromosome

Explore the universe of human proteins at neXtProt for HIST1H2AA: NX_Q96QV6

Explore proteomics data for HIST1H2AA at MOPED 

Post-translational modifications:

  • UniProtKB: The chromatin-associated form is phosphorylated on Thr-121 during mitosis (Probable)
  • UniProtKB: Deiminated on Arg-4 in granulocytes upon calcium entry
  • UniProtKB: Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic
    transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the
    initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome
    chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).
    H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA
    double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase
    UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.
    Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated
    by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to
    monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing
    radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events
  • UniProtKB: Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses
    transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1
  • UniProtKB: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By
    similarity)
  • UniProtKB: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96QV6

    • HIST1H2AA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H2AA Protein Expression
    REFSEQ proteins: NP_734466.1  
    ENSEMBL proteins: 
     ENSP00000297012  

    Human Recombinant Protein Products for HIST1H2AA: 
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    Novus Biologicals HIST1H2AA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIST1H2AA 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    HIST1H2AA for ontologies           About GeneDecksing



    HIST1H2AA Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H2AA
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    Assay Products for HIST1H2AA: 
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    Cloud-Clone Corp. ELISAs for HIST1H2AA 
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    Protein Domains /
    Families
    for HIST1H2AA gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR009072 Histone-fold
     IPR007125 Histone_core_D
     IPR002119 Histone_H2A

    Graphical View of Domain Structure for InterPro Entry Q96QV6

    ProtoNet protein and cluster: Q96QV6

    1 Blocks protein domain: IPB002119 Histone H2A

    UniProtKB/Swiss-Prot: H2A1A_HUMAN, Q96QV6
    Similarity: Belongs to the histone H2A family


    HIST1H2AA for domains           About GeneDecksing


    Function
    for HIST1H2AA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H2A1A_HUMAN, Q96QV6
    Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA
    accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role
    in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is
    regulated via a complex set of post-translational modifications of histones, also called histone code, and
    nucleosome remodeling

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0043565sequence-specific DNA binding ----
    GO:0046982protein heterodimerization activity IEA--
         
    HIST1H2AA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HIST1H2AA:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIST1H2AA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIST1H2AA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H2AA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H2AA 

    miRNA
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    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for HIST1H2AA
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AA


    Pathways & Interactions
    for HIST1H2AA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H2AA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Alcoholism
    		Alcoholism0.34
    		Systemic lupus erythematosus0.34
    2Chromatin Regulation / Acetylation
    		Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HIST1H2AA
        Chromatin Regulation / Acetylation



    2         Kegg Pathways  (Kegg details for HIST1H2AA):
        Alcoholism
    Systemic lupus erythematosus


    HIST1H2AA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H2AA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/26 Interacting proteins for HIST1H2AA (Q96QV62, 3 ENSP000002970124) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRD7Q9NPI12, 3, ENSP000003781804MINT-6665450 I2D: score=1 STRING: ENSP00000378180
    UBCP0CG482, ENSP000003448184MINT-7891787 STRING: ENSP00000344818
    RAD18Q9NS913, ENSP000002649264I2D: score=1 STRING: ENSP00000264926
    DOT1LQ8TEK33, ENSP000003816574I2D: score=1 STRING: ENSP00000381657
    TFAP2BQ924813I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    HIST1H2AA for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H2AA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H2AA (H2A1A)

    1 HMDB Compound for HIST1H2AA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about HIST1H2AA / H2A1A

    Transcripts
    for HIST1H2AA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H2AA gene: 
    NM_170745.3  

    Unigene Cluster for HIST1H2AA:

    Histone cluster 1, H2aa
    Hs.406739  [show with all ESTs]
    Unigene Representative Sequence: BU567795
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000297012(uc003nfc.3)
    miRNA
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    hsa-miR-146a* hsa-miR-1276
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    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H2AA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AA

    Additional mRNA sequence: BC062211.1 

    1 DOTS entry:

    DT.75190550 

    24/42 AceView cDNA sequences (see all 42):

    NM_170745 AI768648 AW779672 AA004989 BX106560 AW000949 AL700122 CB163564 
    BG054690 BC062211 AI522108 AW195710 X71355 AI262144 BX506428 AI433406 
    N53056 NM_005074 BU567795 Y10513 BX106481 CB163294 AI640281 N73241 

    GeneLoc Exon Structure


    Expression
    for HIST1H2AA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H2AA expression in normal human tissues (normalized intensities)      HIST1H2AA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H2AA Expression
    About this image


    HIST1H2AA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Uterus
             uterus, pre-menopause ; glandular cells   

    See HIST1H2AA Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.406739
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    In Situ
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    Orthologs
    for HIST1H2AA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H2AA gene from 4/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hist1h2aa5 histone cluster 1, H2aa   --   13 (10.00 cM) 23934462 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1377261882   -- 76.69(n)    137726188 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0039131 AGAP003913-PA 73.44(n)
    89.43(a)    		   1278737  XM_318365.3  XP_318365.3 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HTA71 histone H2A 7 54.59(n)
    70.08(a)    		   832829  NM_122649.4  NP_198119.1 


    ENSEMBL Gene Tree for HIST1H2AA (if available)
    TreeFam Gene Tree for HIST1H2AA (if available)

    Paralogs
    for HIST1H2AA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H2AA gene
    HIST3H2A2  HIST1H2AJ2  HIST2H2AA42  HIST1H2AE2  HIST1H2AD2  HIST1H2AB2  HIST2H2AC2  HIST2H2AA32  
    HIST2H2AB2  HIST1H2AK2  HIST1H2AI2  HIST1H2AL2  HIST1H2AG2  HIST1H2AC2  H2AFJ2  HIST1H2AM2  
    HIST1H2AH2  
    18/26 SIMAP similar genes for HIST1H2AA using alignment to 1 protein entry:     H2A1A_HUMAN(see all similar genes):
    HIST2H2AB    H2AFX    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE
    HIST1H2AG    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM
    HIST2H2AA3    HIST2H2AA4    HIST3H2A    H2AFJ    HIST1H2AH    HIST2H2AC

    HIST1H2AA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HIST1H2AA
    PGOHUM00000243516


    Genomic Variants
    for HIST1H2AA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/15 SNPs in HIST1H2AA are shown (see all 15)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs93569851,2
    		C,F,A--25728098(+) AAAATC/TAGGTG 1 -- us2k15Minor allele frequency- T:0.37NA WA EA 362
    rs1401866591,2
    		--25728107(+) TGGGCA/GTGGTG 1 -- us2k10--------
    rs1830085911,2
    		C--25728127(+) GTAGTC/GCCAGC 1 -- us2k10--------
    rs77469441,2
    		C,F,A,H--25728176(+) GGAGCC/TGGAGA 1 -- us2k17Minor allele frequency- T:0.17NA WA CSA EA 250
    rs340675421,2
    		C--25728210(+) TGCACT/AACAGC 1 -- us2k13Minor allele frequency- A:0.23NA EA 242
    rs356707311,2
    		C,F--25728235(+) ACTGTC/TTCAAA 1 -- us2k13Minor allele frequency- T:0.23NA EA 242
    rs1503046771,2
    		--25728279(+) AAGCTA/GCATGC 1 -- us2k10--------
    rs1378775861,2
    		--25728325(+) ATAAAA/GCTAAA 1 -- us2k10--------
    rs1418758531,2
    		C--25728469(+) CTGGAA/GAACTC 1 -- us2k10--------
    rs1870159441,2
    		--25728644(+) CTTCCA/TGGAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H2AA (25726291 - 25726790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H2AA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883488CNV Gain21882294

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    Disorders / Diseases
    for HIST1H2AA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 613499    OMIM disorders: --

    3 diseases for HIST1H2AA:    About MalaCards
    riddle syndrome    systemic lupus erythematosus    lupus erythematosus


    HIST1H2AA for disorders           About GeneDecksing


    Export disorders for HIST1H2AA gene to outside databases

    Publications
    for HIST1H2AA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H2AA gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with HIST1H2AA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)1, 2 Bergink S.... Dantuma N.P. (2006)
    3. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)1, 2 Hagiwara T.... Yamada M. (2005)
    4. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)1, 2 Cao R.... Zhang Y. (2005)
    5. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)1, 2 Wang H.... Zhang Y. (2004)
    6. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)1, 2 Zhang Y.... Parvin J.D. (2004)
    7. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)1, 2 Aihara H.... Ito T. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for HIST1H2AA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H2AA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221613 HGNC: 18729 AceView: SLC17A1andHIST1H2AA Ensembl:ENSG00000164508 euGenes: HUgn221613
    ECgene: HIST1H2AA Kegg: 221613 H-InvDB: HIST1H2AA

    Other Databases showing HIST1H2AA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H2AA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H2AA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H2AA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H2AA gene:
    Search GeneIP for patents involving HIST1H2AA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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