HIST1H2AA Gene

Aliases
for HIST1H2AA gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC06M025784 GC06M025834 GC06M025669

Summaries
for HIST1H2AA gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for HIST1H2AA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000006.11  NC_018917.2  NT_007592.16  

SwitchGear Promoter luciferase reporter plasmid: HIST1H2AA promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2AA

HIST1H2AA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M025726:  view genomic region     (about GC identifiers)

Proteins
for HIST1H2AA gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for HIST1H2AA: NX_Q96QV6

Explore proteomics data for HIST1H2AA at MOPED

Post-translational modifications: 

HIST1H2AA Human Recombinant Protein Products:

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	antibodies-online proteins for HIST1H2AA (2 products)
	antibodies-online peptides for HIST1H2AA

HIST1H2AA Antibody Products:

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	antibodies-online antibodies for HIST1H2AA (10 products)

HIST1H2AA Assay Products:

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	antibodies-online kits for HIST1H2AA (2 products)

Domains /
Families
for HIST1H2AA gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96QV6

Find genes that share domains with HIST1H2AA           About GenesLikeMe

Function
for HIST1H2AA gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

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Gene Editing Products:

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AA

Localization
for HIST1H2AA gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for HIST1H2AA gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for HIST1H2AA About     See pathways by source

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	SuperPath	Contained pathways About
1	RNA Polymerase I Promoter Opening	Systemic lupus erythematosus 0.40 HATs acetylate histones 0.34 Chromatin organization 0.34 Alcoholism 0.34 Chromatin modifying enzymes 0.34
2	Chromatin Regulation / Acetylation	Chromatin Regulation / Acetylation

1 Cell Signaling Technology (CST) Pathway for HIST1H2AA

Chromatin Regulation / Acetylation

1 Reactome Pathway for HIST1H2AA

HATs acetylate histones

2 Kegg Pathways  (Kegg details for HIST1H2AA)

	Alcoholism
	Systemic lupus erythematosus

Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for HIST1H2AA gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for HIST1H2AA gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for HIST1H2AA gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HIST1H2AA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Brain (Nervous System)    fully expand to see all 4 entries
Cerebral Cortex
Ovary (Reproductive System)    fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct
Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast
Pancreas (Endocrine System)
Islets of Langerhans
Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AA

Orthologs
for HIST1H2AA gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for HIST1H2AA gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for HIST1H2AA gene

HIST3H2A²  HIST1H2AD²  HIST2H2AA3²  HIST2H2AB²  H2AFX²  HIST1H2AI²  HIST1H2AG²  HIST1H2AC²  

HIST1H2AH²  HIST1H2AM²  HIST1H2AJ²  HIST2H2AA4²  HIST1H2AE²  HIST1H2AB²  HIST2H2AC²  HIST1H2AK²  

HIST1H2AL²  H2AFJ²  

Selected SIMAP similar genes for HIST1H2AA using alignment to 1 protein entry:     H2A1A_HUMAN(see all similar genes):

HIST2H2AB    H2AFX    HIST1H2AB    HIST1H2AC    HIST1H2AD    HIST1H2AE

HIST1H2AG    HIST1H2AI    HIST1H2AJ    HIST1H2AK    HIST1H2AL    HIST1H2AM

HIST2H2AA3    HIST2H2AA4    HIST3H2A    H2AFJ    HIST1H2AH    HIST2H2AC

Find genes that share paralogs with HIST1H2AA           About GenesLikeMe


1 Pseudogenes.org Pseudogene for HIST1H2AA
PGOHUM00000243516

Genomic Variants
for HIST1H2AA gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HIST1H2AA (see all 15)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs93569851,2	C,F,A	--	25728098(+)	AAAATC/TAGGTG	1	--	us2k1		5		NA WA EA	362
rs1401866591,2		--	25728107(+)	TGGGCA/GTGGTG	1	--	us2k1		0	--	--	--	--
rs1830085911,2	C	--	25728127(+)	GTAGTC/GCCAGC	1	--	us2k1		0	--	--	--	--
rs77469441,2	C,F,A,H	--	25728176(+)	GGAGCC/TGGAGA	1	--	us2k1		7		NA WA CSA EA	250
rs340675421,2	C	--	25728210(+)	TGCACT/AACAGC	1	--	us2k1		3		NA EA	242
rs356707311,2	C,F	--	25728235(+)	ACTGTC/TTCAAA	1	--	us2k1		3		NA EA	242
rs1503046771,2		--	25728279(+)	AAGCTA/GCATGC	1	--	us2k1		0	--	--	--	--
rs1378775861,2		--	25728325(+)	ATAAAA/GCTAAA	1	--	us2k1		0	--	--	--	--
rs1418758531,2	C	--	25728469(+)	CTGGAA/GAACTC	1	--	us2k1		0	--	--	--	--
rs1870159441,2		--	25728644(+)	CTTCCA/TGGAAA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for HIST1H2AA (25726291 - 25726790 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for HIST1H2AA:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv883488	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HIST1H2AA

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Disorders / Diseases
for HIST1H2AA gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for HIST1H2AA gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HIST1H2AA gene, integrated from 10 sources (see all 43): (articles sorted by number of sources associating them with HIST1H2AA)

Utopia: connect your pdf to the dynamic world of online information

1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F.... Maltais L.J. (Genomics 2002)
2. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)^{1, 2} Bergink S.... Dantuma N.P. (Genes Dev. 2006)
3. Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)^{1, 2} Hagiwara T.... Yamada M. (Biochemistry 2005)
4. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)^{1, 2} Cao R.... Zhang Y. (Mol. Cell 2005)
5. Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)^{1, 2} Wang H.... Zhang Y. (Nature 2004)
6. Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)^{1, 2} Zhang Y.... Parvin J.D. (J. Biol. Chem. 2004)
7. Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)^{1, 2} Aihara H.... Ito T. (Genes Dev. 2004)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
10. Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. (PubMed id 24352239)² Tessarz P.... Kouzarides T. (Nature 2014)

External Searches for HIST1H2AA gene

Genome Databases showing HIST1H2AA gene

Other Databases showing HIST1H2AA gene

Specialized Databases showing HIST1H2AA gene

Products
for HIST1H2AA gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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