Aliases for HIST1H2AA Gene
External Ids for HIST1H2AA Gene
Previous GeneCards Identifiers for HIST1H2AA Gene
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Jul 2008]
GeneCards Summary for HIST1H2AA Gene
HIST1H2AA (Histone Cluster 1, H2aa) is a Protein Coding gene. Diseases associated with HIST1H2AA include riddle syndrome and hiv-1. Among its related pathways are Chromatin Regulation / Acetylation and RNA Polymerase I Promoter Opening. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST1H2AM.
UniProtKB/Swiss-Prot for HIST1H2AA Gene
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling