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HIST1H2AA Gene

protein-coding GIFtS: 53
GCID: GC06M025726

Histone Cluster 1, H2aa

(Previous names: H2A histone family, member R, histone 1, H2aa)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Histone Cluster 1, H2aa¹ ²		H2AA² ⁵
H2AFR² ³ ⁵		bA317E16.2²
H2A Histone Family, Member R¹ ²		Histone H2A Type 1-A²
Histone 1, H2aa¹ ²		HISTH2AA⁵
Histone H2A/R² ³

External Ids:	HGNC: 18729¹	Entrez Gene: 221613²	Ensembl: ENSG00000164508⁷	OMIM: 613499⁵	UniProtKB: Q96QV6³

Export aliases for HIST1H2AA gene to outside databases

Previous GC identifers: GC06M025784 GC06M025834 GC06M025669

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H2AA Gene:

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in

eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs

of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the

interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin

structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene

contain a palindromic termination element. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H2AA Gene:

HIST1H2AA (histone cluster 1, H2aa) is a protein-coding gene. Diseases associated with HIST1H2AA include riddle syndrome, and systemic lupus erythematosus. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is HIST3H2A.

UniProtKB/Swiss-Prot: H2A1A_HUMAN, Q96QV6

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA

accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role

in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is

regulated via a complex set of post-translational modifications of histones, also called histone code, and

nucleosome remodeling

Gene Wiki entry for HIST1H2AA Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000006.12 NC_018917.2 NT_007592.16

Regulatory elements:

Regulatory transcription factor binding sites in the HIST1H2AA gene promoter:
Max E2F-1 E2F POU2F1a ZID TGIF Pax-4a c-Myc Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H2AA promoter sequence

Search Chromatin IP Primers for HIST1H2AA

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H2AA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.2 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.2

HIST1H2AA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H2AA gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M025726: view genomic region (about GC identifiers)

Start:	25,726,291 bp from pter	End:	25,726,790 bp from pter
Size:	500 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H2A1A_HUMAN, Q96QV6 (See protein sequence)

Recommended Name: Histone H2A type 1-A

Size: 131 amino acids; 14234 Da

Subunit: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one

H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA

Explore the universe of human proteins at neXtProt for HIST1H2AA: NX_Q96QV6

Explore proteomics data for HIST1H2AA at MOPED

Post-translational modifications:

Deiminated on Arg-4 in granulocytes upon calcium entry¹

Monoubiquitination of Lys-120 (H2AK119Ub) by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic

transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the

initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome

chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me).

H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA

double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase

UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage.

Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated

by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to

monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. H2AK119Ub and ionizing

radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events¹

Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly

represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at

Thr-121 (H2AT120ph) by VPRBP is present in the regulatory region of many tumor suppresor genes and down-regulates

their transcription¹

Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at

35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239)¹

Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage (By

similarity)¹

Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic

cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks

active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with

post-meiotically activated genes on autosomes¹

Ubiquitination² at Lys14, Lys16, Lys96, Lys119

Modification sites at PhosphoSitePlus

See HIST1H2AA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_734466.1

ENSEMBL proteins:

ENSP00000297012

Reactome Protein details: Q96QV6

HIST1H2AA Human Recombinant Protein Products:

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HIST1H2AA Assay Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

HIST: Histones / Replication-dependent

3 InterPro protein domains:

IPR009072 Histone-fold

IPR007125 Histone_core_D

IPR002119 Histone_H2A

Graphical View of Domain Structure for InterPro Entry Q96QV6

ProtoNet protein and cluster: Q96QV6

1 Blocks protein domain: IPB002119 Histone H2A

UniProtKB/Swiss-Prot: H2A1A_HUMAN, Q96QV6

Similarity: Belongs to the histone H2A family

HIST1H2AA for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: H2A1A_HUMAN, Q96QV6

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA

accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role

in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is

regulated via a complex set of post-translational modifications of histones, also called histone code, and

nucleosome remodeling

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0043565	sequence-specific DNA binding	--	--
GO:0046982	protein heterodimerization activity	IEA	--

HIST1H2AA for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for HIST1H2AA:

Synthetic lethal with Ras

Animal Models:

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genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H2AA

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AA

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

H2A1A_HUMAN, Q96QV6: Nucleus. Chromosome

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5

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Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	IEA	--
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IEA	--

HIST1H2AA for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HIST1H2AA About

See pathways by source

SuperPath

Contained pathways About

RNA Polymerase I Promoter Opening

Systemic lupus erythematosus	0.40	Chromatin organization	0.34
HATs acetylate histones	0.34	Alcoholism	0.34
Chromatin modifying enzymes	0.34

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

Pathways by source See SuperPaths
Show all pathways

1 Cell Signaling Technology (CST) Pathway for HIST1H2AA

Chromatin Regulation / Acetylation

1 Reactome Pathway for HIST1H2AA

HATs acetylate histones

2 Kegg Pathways (Kegg details for HIST1H2AA):

	Alcoholism
	Systemic lupus erythematosus

HIST1H2AA for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for HIST1H2AA
Interactions:

Search GeneGlobe Interaction Network for HIST1H2AA

STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

Selected Interacting proteins for HIST1H2AA (Q96QV6^{2, 3} ENSP00000297012⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BRD7	Q9NPI1²^,³, ENSP00000378180⁴	MINT-6665450 I2D: score=1 STRING: ENSP00000378180
UBC	P0CG48², ENSP00000344818⁴	MINT-7891787 STRING: ENSP00000344818
RAD18	Q9NS91³, ENSP00000264926⁴	I2D: score=1 STRING: ENSP00000264926
DOT1L	Q8TEK3³, ENSP00000381657⁴	I2D: score=1 STRING: ENSP00000381657
TFAP2B	Q92481³	I2D: score=1

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Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	IEA	--

HIST1H2AA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for HIST1H2AA (H2A1A)

1 HMDB Compound for HIST1H2AA About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HIST1H2AA gene:

NM_170745.3

Unigene Cluster for HIST1H2AA:

Histone cluster 1, H2aa

Hs.406739 [show with all ESTs]

Unigene Representative Sequence: BU567795

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000297012(uc003nfc.3)

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		QuantiFast Probe-based Assays in human, mouse, rat HIST1H2AA

Additional mRNA sequence: BC062211.1

1 DOTS entry:

DT.75190550

Selected AceView cDNA sequences (see all 42):

AA004989 AI768648 AW000949 AW779672 NM_170745 BX106560 N53056 AI640281

Y10513 CB163564 BX106481 BX506428 CB163294 AL700122 BG054690 BC062211

BU567795 AI522108 X71355 AI262144 N73241 AI433406 AW195710 NM_005074

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HIST1H2AA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

HIST1H2AA expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 6) fully expand


Brain (Nervous System) fully expand to see all 4 entries
Cerebral Cortex

Ovary (Reproductive System) fully expand to see all 2 entries
Ovarian Mesenchymal Stroma Cells Ovary Interstitium
Oviduct

Trophoblast (Extraembryonic Tissues)
Trophoblast Cells Trophoblast

Pancreas (Endocrine System)
Islets of Langerhans

Liver (Hepatobiliary System)
Hepatocytes Liver Lobule

HIST1H2AA Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

HIST1H2AA Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.406739

Custom PCR Arrays for HIST1H2AA

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H2AA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HIST1H2AA gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hist1h2aa⁵ Hist1h2ak¹	histone cluster 1, H2aa⁵ histone cluster 1, H2ak¹	78.46(n)¹ 92.31(a)¹		13 (10.00 cM)⁵ 319169¹ NM_178183.1¹ NP_835490.1¹ 23934462⁵
lizard (Anolis carolinensis)	Reptilia	--	--	85(a)	many ↔ many	2(164703263-164703927)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137726188²	--	76.69(n)		137726188
zebrafish (Danio rerio)	Actinopterygii	zgc:163047⁶ zgc:101846⁶ (see all 13)	zgc:101846 (see all 13)	91(a) 91(a) (see all 13)	many ↔ many many ↔ many (see all 13)	7(7241510-7241893) ENSDARG00000094931 10(30724438-30725346) ENSDARG00000068995

ENSEMBL Gene Tree for HIST1H2AA (if available)
TreeFam Gene Tree for HIST1H2AA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HIST1H2AA gene

HIST3H2A² HIST1H2AD² HIST2H2AA3² HIST2H2AB² H2AFX² HIST1H2AI² HIST1H2AG² HIST1H2AC²

HIST1H2AH² HIST1H2AM² HIST1H2AJ² HIST2H2AA4² HIST1H2AE² HIST1H2AB² HIST2H2AC² HIST1H2AK²

HIST1H2AL² H2AFJ²

Selected SIMAP similar genes for HIST1H2AA using alignment to 1 protein entry: H2A1A_HUMAN(see all similar genes):

HIST2H2AB H2AFX HIST1H2AB HIST1H2AC HIST1H2AD HIST1H2AE

HIST1H2AG HIST1H2AI HIST1H2AJ HIST1H2AK HIST1H2AL HIST1H2AM

HIST2H2AA3 HIST2H2AA4 HIST3H2A H2AFJ HIST1H2AH HIST2H2AC

HIST1H2AA for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for HIST1H2AA
PGOHUM00000243516

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9356985^1,2	C,F,A	--	25728098(+)	`AAAATC/TAGGTG`	1	--	us2k¹		5		NA WA EA	362
rs140186659^1,2		--	25728107(+)	`TGGGCA/GTGGTG`	1	--	us2k¹		0	--	--	--	--
rs183008591^1,2	C	--	25728127(+)	`GTAGTC/GCCAGC`	1	--	us2k¹		0	--	--	--	--
rs7746944^1,2	C,F,A,H	--	25728176(+)	`GGAGCC/TGGAGA`	1	--	us2k¹		7		NA WA CSA EA	250
rs34067542^1,2	C	--	25728210(+)	`TGCACT/AACAGC`	1	--	us2k¹		3		NA EA	242
rs35670731^1,2	C,F	--	25728235(+)	`ACTGTC/TTCAAA`	1	--	us2k¹		3		NA EA	242
rs150304677^1,2		--	25728279(+)	`AAGCTA/GCATGC`	1	--	us2k¹		0	--	--	--	--
rs137877586^1,2		--	25728325(+)	`ATAAAA/GCTAAA`	1	--	us2k¹		0	--	--	--	--
rs141875853^1,2	C	--	25728469(+)	`CTGGAA/GAACTC`	1	--	us2k¹		0	--	--	--	--
rs187015944^1,2		--	25728644(+)	`CTTCCA/TGGAAA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HIST1H2AA (25726291 - 25726790 bp)

Structural Variations
Database of Genomic Variants (DGV) 1 variation for HIST1H2AA: About this table

Variant ID	Type	Subtype	PubMed ID
nsv883488	CNV	Gain	21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 613499 OMIM disorders: --

9 diseases for HIST1H2AA:
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riddle syndrome systemic lupus erythematosus hiv-1 tonsillitis

lupus erythematosus malaria cerebritis thyroiditis

endotheliitis

HIST1H2AA for disorders About GeneDecksing

Export disorders for HIST1H2AA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HIST1H2AA gene, integrated from 10 sources (see all 43):
(articles sorted by number of sources associating them with HIST1H2AA)

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The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F.... Maltais L.J. (Genomics 2002)
DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A. (PubMed id 16702407)^{1, 2} Bergink S.... Dantuma N.P. (Genes Dev. 2006)
Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes. (PubMed id 15823041)^{1, 2} Hagiwara T.... Yamada M. (Biochemistry 2005)
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. (PubMed id 16359901)^{1, 2} Cao R.... Zhang Y. (Mol. Cell 2005)
Role of histone H2A ubiquitination in Polycomb silencing. (PubMed id 15386022)^{1, 2} Wang H.... Zhang Y. (Nature 2004)
Phosphorylation of histone H2A inhibits transcription on chromatin templates. (PubMed id 15010469)^{1, 2} Zhang Y.... Parvin J.D. (J. Biol. Chem. 2004)
Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during mitosis in the early Drosophila embryo. (PubMed id 15078818)^{1, 2} Aihara H.... Ito T. (Genes Dev. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (Nature 2003)
Glutamine methylation in histone H2A is an RNA-polymerase-I-dedicated modification. (PubMed id 24352239)² Tessarz P.... Kouzarides T. (Nature 2014)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 221613	HGNC: 18729	AceView: SLC17A1andHIST1H2AA	Ensembl:ENSG00000164508	euGenes: HUgn221613
ECgene: HIST1H2AA	Kegg: 221613	H-InvDB: HIST1H2AA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HIST1H2AA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HIST1H2AA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HIST1H2AA gene:
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