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Aliases for HIST1H1T Gene

Aliases for HIST1H1T Gene

  • Histone Cluster 1, H1t 2 3 5
  • H1 Histone Family, Member T (Testis-Specific) 2 3
  • Testicular H1 Histone 3 4
  • Histone 1, H1t 2 3
  • H1FT 3 4
  • H1t 3 4
  • DJ221C16.2 3
  • H1.6 3

External Ids for HIST1H1T Gene

Previous HGNC Symbols for HIST1H1T Gene

  • H1FT

Previous GeneCards Identifiers for HIST1H1T Gene

  • GC06M026165
  • GC06M026215
  • GC06M026050

Summaries for HIST1H1T Gene

Entrez Gene Summary for HIST1H1T Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H1T Gene

HIST1H1T (Histone Cluster 1, H1t) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Cell cycle_Chromosome condensation in prometaphase. An important paralog of this gene is HIST1H1D.

UniProtKB/Swiss-Prot for HIST1H1T Gene

  • Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).

Gene Wiki entry for HIST1H1T Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1T Gene

Genomics for HIST1H1T Gene

Regulatory Elements for HIST1H1T Gene

Genomic Location for HIST1H1T Gene

Chromosome:
6
Start:
26,107,412 bp from pter
End:
26,108,136 bp from pter
Size:
725 bases
Orientation:
Minus strand

Genomic View for HIST1H1T Gene

Genes around HIST1H1T on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H1T Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H1T Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1T Gene

Proteins for HIST1H1T Gene

  • Protein details for HIST1H1T Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22492-H1T_HUMAN
    Recommended name:
    Histone H1t
    Protein Accession:
    P22492
    Secondary Accessions:
    • Q6ISI1
    • Q8IUE8

    Protein attributes for HIST1H1T Gene

    Size:
    207 amino acids
    Molecular mass:
    22019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HIST1H1T Gene

Proteomics data for HIST1H1T Gene at MOPED

Post-translational modifications for HIST1H1T Gene

  • Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • Phosphorylated in early spermatids.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIST1H1T Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST1H1T Gene

Domains & Families for HIST1H1T Gene

Gene Families for HIST1H1T Gene

Protein Domains for HIST1H1T Gene

Suggested Antigen Peptide Sequences for HIST1H1T Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22492

UniProtKB/Swiss-Prot:

H1T_HUMAN :
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
  • Belongs to the histone H1/H5 family.
Domain:
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1T: view

Function for HIST1H1T Gene

Molecular function for HIST1H1T Gene

UniProtKB/Swiss-Prot Function:
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).
genes like me logo Genes that share phenotypes with HIST1H1T: view

Animal Models for HIST1H1T Gene

MGI Knock Outs for HIST1H1T:

Animal Model Products

  • Taconic Biosciences Mouse Models for HIST1H1T

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIST1H1T Gene

Localization for HIST1H1T Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1T Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H1T Gene COMPARTMENTS Subcellular localization image for HIST1H1T gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for HIST1H1T Gene

Pathways & Interactions for HIST1H1T Gene

genes like me logo Genes that share pathways with HIST1H1T: view

Pathways by source for HIST1H1T Gene

2 Qiagen pathways for HIST1H1T Gene

Gene Ontology (GO) - Biological Process for HIST1H1T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with HIST1H1T: view

No data available for SIGNOR curated interactions for HIST1H1T Gene

Drugs & Compounds for HIST1H1T Gene

(1) Additional Compounds for HIST1H1T Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HIST1H1T: view

Transcripts for HIST1H1T Gene

mRNA/cDNA for HIST1H1T Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1T Gene

Histone cluster 1, H1t:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1T Gene

No ASD Table

Relevant External Links for HIST1H1T Gene

GeneLoc Exon Structure for
HIST1H1T
ECgene alternative splicing isoforms for
HIST1H1T

Expression for HIST1H1T Gene

mRNA expression in normal human tissues for HIST1H1T Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1T Gene

This gene is overexpressed in Testis (x16.4) and Whole Blood (x6.4).

Protein differential expression in normal tissues from HIPED for HIST1H1T Gene

This gene is overexpressed in Testis (37.1) and Ovary (24.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H1T Gene



SOURCE GeneReport for Unigene cluster for HIST1H1T Gene Hs.533293

mRNA Expression by UniProt/SwissProt for HIST1H1T Gene

P22492-H1T_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with HIST1H1T: view

Protein tissue co-expression partners for HIST1H1T Gene

Primer Products

In Situ Assay Products

Orthologs for HIST1H1T Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1T Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HIST1H1T 35
  • 70.55 (n)
  • 68.45 (a)
HIST1H1T 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist1h1t 35
  • 67.32 (n)
  • 64.04 (a)
Hist1h1t 16
Hist1h1t 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC471879 35
  • 98.23 (n)
  • 97.1 (a)
HIST1H1T 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hist1h1t 35
  • 68.8 (n)
  • 65.52 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
OneToMany
chicken
(Gallus gallus)
Aves HIST1H111R 35
  • 58.54 (n)
  • 54.82 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
-- 36
  • 40 (a)
ManyToMany
-- 36
  • 74 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732947 35
  • 58.94 (n)
  • 55.07 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:163061 35
  • 66.2 (n)
  • 69.01 (a)
CABZ01086354.1 36
  • 52 (a)
ManyToMany
CU457819.3 36
  • 50 (a)
ManyToMany
FP325123.1 36
  • 50 (a)
ManyToMany
histh1l 36
  • 47 (a)
ManyToMany
si:ch211-113a14.12 36
  • 44 (a)
ManyToMany
si:ch211-113a14.18 36
  • 45 (a)
ManyToMany
si:ch211-113a14.24 36
  • 45 (a)
ManyToMany
si:dkey-108k21.10 36
  • 45 (a)
ManyToMany
si:dkey-108k21.14 36
  • 45 (a)
ManyToMany
si:dkey-108k21.21 36
  • 41 (a)
ManyToMany
si:dkey-261m9.12 36
  • 45 (a)
ManyToMany
zgc:110425 36
  • 47 (a)
ManyToMany
zgc:153405 36
  • 45 (a)
ManyToMany
zgc:163061 36
  • 57 (a)
ManyToMany
zgc:163061 36
  • 57 (a)
ManyToMany
Species with no ortholog for HIST1H1T:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1T Gene

ENSEMBL:
Gene Tree for HIST1H1T (if available)
TreeFam:
Gene Tree for HIST1H1T (if available)

Paralogs for HIST1H1T Gene

Paralogs for HIST1H1T Gene

(6) SIMAP similar genes for HIST1H1T Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HIST1H1T: view

Variants for HIST1H1T Gene

Sequence variations from dbSNP and Humsavar for HIST1H1T Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs198844 - 26,108,054(+) GGCTA(A/C/G)ACCAG reference, missense
rs2051542 - 26,107,940(-) AGGCC(C/T)TTTCA reference, missense
rs198845 - 26,107,562(+) CTGCT(G/T)TTGCT reference, missense
rs198843 -- 26,110,086(+) AAGTG(A/T)GATAG upstream-variant-2KB
rs198846 -- 26,107,235(+) cgggg(A/G)aatga downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1T Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914

Variation tolerance for HIST1H1T Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.94; 79.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H1T Gene

HapMap Linkage Disequilibrium report
HIST1H1T

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1T Gene

Disorders for HIST1H1T Gene

Relevant External Links for HIST1H1T

Genetic Association Database (GAD)
HIST1H1T
Human Genome Epidemiology (HuGE) Navigator
HIST1H1T
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H1T

No disorders were found for HIST1H1T Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1T Gene

Publications for HIST1H1T Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. Expression of mRNA and protein of nucleoproteins during human spermiogenesis. (PMID: 9809674) Steger K. … Bergmann M. (Mol. Hum. Reprod. 1998) 3 23
  3. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 3 23
  4. Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6. (PMID: 8175896) Koppel D.A. … Grimes S.R. (J. Cell. Biochem. 1994) 2 3
  5. Structure and expression of the human gene encoding testicular H1 histone (H1t). (PMID: 1889752) Drabent B. … Doenecke D. (Gene 1991) 3 23

Products for HIST1H1T Gene

Sources for HIST1H1T Gene

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