Aliases for HIST1H1T Gene
Aliases for HIST1H1T Gene
External Ids for HIST1H1T Gene
- HGNC: 4720
- Entrez Gene: 3010
- Ensembl: ENSG00000187475
- OMIM: 142712
- UniProtKB: P22492
Previous HGNC Symbols for HIST1H1T Gene
- H1FT
Previous GeneCards Identifiers for HIST1H1T Gene
- GC06M026165
- GC06M026215
- GC06M026050
Summaries for HIST1H1T Gene
-
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H1T Gene
HIST1H1T (Histone Cluster 1 H1 Family Member T) is a Protein Coding gene. Among its related pathways are Apoptosis induced DNA fragmentation and Cell cycle_Chromosome condensation in prometaphase. An important paralog of this gene is HIST1H1E.
UniProtKB/Swiss-Prot for HIST1H1T Gene
-
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1T Gene
Genomics for HIST1H1T Gene
Regulatory Elements for HIST1H1T Gene
Enhancers for HIST1H1T Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G026086 | 1 | ENCODE | 11.8 | +20.1 | 20061 | 2.8 | CREB3L1 AGO1 SIN3A DMAP1 YY1 SLC30A9 ZNF766 KLF13 SMARCB1 ZNF592 | ENSG00000272462 HIST1H1C HIST1H1T LARP1P1 HIST1H2BE BTN3A2 HFE GC06P026096 |
| GH06G026060 | 0.7 | Ensembl ENCODE | 11.3 | +47.9 | 47936 | 0.4 | CEBPB ZBTB33 | HIST1H4C HFE HIST1H1T HIST1H2BD HIST1H1E ENSG00000272462 LARP1P1 HIST1H2BE HMGN4 HIST1H1C |
| GH06G026087 | 0.4 | ENCODE | 11.8 | +21.7 | 21709 | 0.2 | PKNOX1 | ENSG00000272462 HIST1H1C HIST1H1T LARP1P1 HIST1H2BE HFE GC06P026086 |
| GH06G026005 | 0.3 | FANTOM5 | 4.4 | +102.3 | 102336 | 0.0 | HIST1H1T HIST1H2AA HIST1H2BA HIST1H4G ENSG00000272558 ENSG00000272810 | |
| GH06G026118 | 1.1 | ENCODE dbSUPER | 0.4 | -10.9 | -10851 | 0.8 | HDAC1 ATF1 TBL1XR1 CHAMP1 ZNF335 GATA2 EGR1 CREM SMAD5 ZNF592 | ENSG00000272462 BTN3A2 PIR32750 HIST1H1T |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H1T on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST1H1T gene promoter:
Regulatory Element Products
Genomic Location for HIST1H1T Gene
- Chromosome:
- 6
- Start:
- 26,107,412 bp from pter
- End:
- 26,108,136 bp from pter
- Size:
- 725 bases
- Orientation:
- Minus strand
Genomic View for HIST1H1T Gene
Genes around HIST1H1T on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H1T Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H1T Gene
Proteins for HIST1H1T Gene
-
Protein details for HIST1H1T Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P22492-H1T_HUMAN
- Recommended name:
- Histone H1t
- Protein Accession:
- P22492
- Q6ISI1
- Q8IUE8
Protein attributes for HIST1H1T Gene
- Size:
- 207 amino acids
- Molecular mass:
- 22019 Da
- Quaternary structure:
- No Data Available
Protein Expression for HIST1H1T Gene
Post-translational modifications for HIST1H1T Gene
- Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
- Phosphorylated in early spermatids.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HIST1H1T Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HIST1H1T
- Novus Biologicals Antibodies for HIST1H1T
- Invitrogen Antibodies for HIST1H1T
- antibodies-online Antibodies for HIST1H1T: See all 7
- GeneTex HIST1H1T antibody for HIST1H1T
Protein Products
-
OriGene Purified Proteins for HIST1H1T
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H1T
- Origene Custom Protein Services for HIST1H1T
- Novus Biologicals proteins for HIST1H1T
- antibodies-online Proteins for HIST1H1T: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HIST1H1T
Assay Products
- antibodies-online Kits for HIST1H1T: See all 2
No data available for DME Specific Peptides for HIST1H1T Gene
Domains & Families for HIST1H1T Gene
Gene Families for HIST1H1T Gene
- HGNC:
Protein Domains for HIST1H1T Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H1T Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P22492- Family:
-
- Belongs to the histone H1/H5 family.
Function for HIST1H1T Gene
Molecular function for HIST1H1T Gene
- UniProtKB/Swiss-Prot Function:
- Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for HIST1H1T Gene
- MGI mutant phenotypes for HIST1H1T:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for HIST1H1T:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H1T gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1T gene
- Search ViGene Biosciences for HIST1H1T
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H1T
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H1T
- GenScript: Design CRISPR guide RNA sequences for HIST1H1T
miRNA for HIST1H1T Gene
- miRTarBase miRNAs that target HIST1H1T
miRNA Products
- Search ViGene Biosciences for HIST1H1T
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H1T
- Browse OriGene Inhibitory RNA Products For HIST1H1T
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1T gene
Clone Products
-
OriGene ORF clones in human for HIST1H1T
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H1T
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIST1H1T
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H1T gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H1T gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1T gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIST1H1T Gene
Localization for HIST1H1T Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1T Gene
- Nucleus. Chromosome.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for HIST1H1T Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis induced DNA fragmentation | ||
| 2 | Activation of cAMP-Dependent PKA |
.56
|
|
| 3 | E2F mediated regulation of DNA replication | ||
| 4 | Cell cycle_Chromosome condensation in prometaphase | ||
Pathways by source for HIST1H1T Gene
2 GeneGo (Thomson Reuters) pathways for HIST1H1T Gene
2 Qiagen pathways for HIST1H1T Gene
Interacting Proteins for HIST1H1T Gene
Selected Interacting proteins:
ENSP00000341214
P22492-H1T_HUMAN
for HIST1H1T Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | TAS,IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
No data available for SIGNOR curated interactions for HIST1H1T Gene
Transcripts for HIST1H1T Gene
mRNA/cDNA for HIST1H1T Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H1T Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H1T
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H1T
- GenScript: Design CRISPR guide RNA sequences for HIST1H1T
miRNA Products
- Search ViGene Biosciences for HIST1H1T
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H1T
- Browse OriGene Inhibitory RNA Products For HIST1H1T
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1T gene
Clone Products
-
OriGene ORF clones in human for HIST1H1T
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HIST1H1T
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIST1H1T Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Secondary Spermatocyte Seminiferous Tubules
- Long-time differentiated EBs(West JA et. al. 2006)
- Neural Tube (Nervous System)
-
Gonad
- Secondary Spermatocyte Seminiferous Tubules
- Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for HIST1H1T Gene
This gene is overexpressed in Testis (x16.4) and Whole Blood (x6.4).
This gene is overexpressed in Testis (37.1) and Ovary (24.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H1T Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H1T Gene:
HIST1H1TSOURCE GeneReport for Unigene cluster for HIST1H1T Gene:
Hs.533293mRNA Expression by UniProt/SwissProt for HIST1H1T Gene:
P22492-H1T_HUMAN
Tissue specificity:
Testis-specific.
Primer Products
-
OriGene qPCR primer pairs for HIST1H1T
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H1T Gene
Orthologs for HIST1H1T Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LOC471879 34 |
|
||
| HIST1H1T 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | HIST1H1T 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hist1h1t 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hist1h1t 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | HIST1H111R 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101732947 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:163061 35 35 34 |
|
ManyToMany | |
| CABZ01086354.1 35 |
|
ManyToMany | |||
| CU457819.3 35 |
|
ManyToMany | |||
| FP325123.1 35 |
|
ManyToMany | |||
| histh1l 35 |
|
ManyToMany | |||
| zgc:110425 35 |
|
ManyToMany | |||
| si:dkey-261m9.12 35 |
|
ManyToMany | |||
| zgc:153405 35 |
|
ManyToMany | |||
| si:dkey-108k21.14 35 |
|
ManyToMany | |||
| si:dkey-108k21.10 35 |
|
ManyToMany | |||
| si:ch211-113a14.24 35 |
|
ManyToMany | |||
| si:ch211-113a14.18 35 |
|
ManyToMany | |||
| si:ch211-113a14.12 35 |
|
ManyToMany | |||
| si:dkey-108k21.21 35 |
|
ManyToMany |
- Species where no ortholog for HIST1H1T was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST1H1T Gene
Variants for HIST1H1T Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000644003 | -- | 26,110,004(+) | CAGTG(G/T)GGTAA | upstream-variant-2KB | |
| rs1002618064 | -- | 26,107,122(+) | GCAGC(-/T)TAACC | downstream-variant-500B | |
| rs1004489154 | -- | 26,107,997(+) | ACTTA(C/T)CAAGC | reference, missense | |
| rs1004518794 | -- | 26,108,094(+) | GACAT(A/G)ACAAC | utr-variant-5-prime | |
| rs1004547727 | -- | 26,107,545(+) | GCCTT(C/T)ACTGG | reference, synonymous-codon |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| esv3608393 | CNV | gain | 21293372 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.94;
79.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H1T Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H1T
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1T Gene
Disorders for HIST1H1T Gene
Relevant External Links for HIST1H1T
No disorders were found for HIST1H1T Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1T Gene
Publications for HIST1H1T Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6. (PMID: 8175896) Koppel D.A. … Grimes S.R. (J. Cell. Biochem. 1994) 2 3 4 64
- Structure and expression of the human gene encoding testicular H1 histone (H1t). (PMID: 1889752) Drabent B. … Doenecke D. (Gene 1991) 3 4 22 64
- Relaxed chromatin formation and weak suppression of homologous pairing by the testis-specific linker histone H1T. (PMID: 26757249) Machida S. … Kurumizaka H. (Biochemistry 2016) 3 4 64
- Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain L.V. … van Duijn C.M. (Nat. Genet. 2011) 3 46 64
Products for HIST1H1T Gene
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- ViGene Biosciences adenoviral particle packaged cDNA for HIST1H1T gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H1T Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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