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Aliases for HIST1H1T Gene

Aliases for HIST1H1T Gene

  • Histone Cluster 1, H1t 2 3
  • H1FT 3 4 6
  • H1 Histone Family, Member T (Testis-Specific) 2 3
  • Testicular H1 Histone 3 4
  • Histone 1, H1t 2 3
  • H1t 3 4
  • Histone H1t 3
  • DJ221C16.2 3
  • H1.6 3

External Ids for HIST1H1T Gene

Previous HGNC Symbols for HIST1H1T Gene

  • H1FT

Previous GeneCards Identifiers for HIST1H1T Gene

  • GC06M026165
  • GC06M026215
  • GC06M026050

Summaries for HIST1H1T Gene

Entrez Gene Summary for HIST1H1T Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H1T Gene

HIST1H1T (Histone Cluster 1, H1t) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and E2F mediated regulation of DNA replication. An important paralog of this gene is HIST1H1D.

UniProtKB/Swiss-Prot for HIST1H1T Gene

  • Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures

Gene Wiki entry for HIST1H1T Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1T Gene

Genomics for HIST1H1T Gene

Regulatory Elements for HIST1H1T Gene

Genomic Location for HIST1H1T Gene

26,107,412 bp from pter
26,108,136 bp from pter
725 bases
Minus strand

Genomic View for HIST1H1T Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H1T Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1T Gene

Proteins for HIST1H1T Gene

  • Protein details for HIST1H1T Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone H1t
    Protein Accession:
    Secondary Accessions:
    • Q6ISI1
    • Q8IUE8

    Protein attributes for HIST1H1T Gene

    207 amino acids
    Molecular mass:
    22019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HIST1H1T Gene

Proteomics data for HIST1H1T Gene at MOPED

Post-translational modifications for HIST1H1T Gene

  • Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • Phosphorylated in early spermatids.
  • Ubiquitination at Lys68 and Lys79
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H1T Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H1T Gene

Domains for HIST1H1T Gene

Gene Families for HIST1H1T Gene

  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H1T Gene

Suggested Antigen Peptide Sequences for HIST1H1T Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P22492
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1T: view

Function for HIST1H1T Gene

Molecular function for HIST1H1T Gene

UniProtKB/Swiss-Prot Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures

Gene Ontology (GO) - Molecular Function for HIST1H1T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with HIST1H1T: view

Phenotypes for HIST1H1T Gene

MGI mutant phenotypes for HIST1H1T:
inferred from 3 alleles
GenomeRNAi human phenotypes for HIST1H1T:
genes like me logo Genes that share phenotypes with HIST1H1T: view

Animal Models for HIST1H1T Gene

MGI Knock Outs for HIST1H1T:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H1T

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HIST1H1T Gene

Localization for HIST1H1T Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1T Gene

Nucleus. Chromosome.

Subcellular locations from

Jensen Localization Image for HIST1H1T Gene COMPARTMENTS Subcellular localization image for HIST1H1T gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HIST1H1T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000794 condensed nuclear chromosome IEA --
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
genes like me logo Genes that share ontologies with HIST1H1T: view

Pathways for HIST1H1T Gene

genes like me logo Genes that share pathways with HIST1H1T: view

Pathways by source for HIST1H1T Gene

2 Qiagen pathways for HIST1H1T Gene

Gene Ontology (GO) - Biological Process for HIST1H1T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007339 binding of sperm to zona pellucida IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HIST1H1T: view

Compounds for HIST1H1T Gene

(1) Novoseek inferred chemical compound relationships for HIST1H1T Gene

Compound -log(P) Hits PubMed IDs
protamine 59.8 2
genes like me logo Genes that share compounds with HIST1H1T: view

Transcripts for HIST1H1T Gene

mRNA/cDNA for HIST1H1T Gene

(5) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1T Gene

Histone cluster 1, H1t:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H1T

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HIST1H1T

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1T Gene

No ASD Table

Relevant External Links for HIST1H1T Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIST1H1T Gene

mRNA expression in normal human tissues for HIST1H1T Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1T Gene

This gene is overexpressed in Testis (16.4) and Whole Blood (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H1T Gene

SOURCE GeneReport for Unigene cluster for HIST1H1T Gene Hs.533293

genes like me logo Genes that share expressions with HIST1H1T: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H1T Gene

Orthologs for HIST1H1T Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1T Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HIST1H1T 36
  • 96 (a)
LOC471879 35
  • 98.23 (n)
  • 97.1 (a)
(Canis familiaris)
Mammalia HIST1H1T 35
  • 70.55 (n)
  • 68.45 (a)
  • 67 (a)
(Mus musculus)
Mammalia Hist1h1t 35
  • 67.32 (n)
  • 64.04 (a)
Hist1h1t 16
Hist1h1t 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 28 (a)
(Rattus norvegicus)
Mammalia Hist1h1t 35
  • 68.8 (n)
  • 65.52 (a)
(Gallus gallus)
Aves HIST1H111R 35
  • 58.54 (n)
  • 54.82 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
-- 36
  • 43 (a)
-- 36
  • 40 (a)
-- 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732947 35
  • 58.94 (n)
  • 55.07 (a)
(Danio rerio)
Actinopterygii CABZ01086354.1 36
  • 52 (a)
CU457819.3 36
  • 50 (a)
FP325123.1 36
  • 50 (a)
histh1l 36
  • 47 (a)
si:ch211-113a14.12 36
  • 44 (a)
si:ch211-113a14.18 36
  • 45 (a)
si:ch211-113a14.24 36
  • 45 (a)
si:dkey-108k21.10 36
  • 45 (a)
si:dkey-108k21.14 36
  • 45 (a)
si:dkey-108k21.21 36
  • 41 (a)
si:dkey-261m9.12 36
  • 45 (a)
zgc:110425 36
  • 47 (a)
zgc:153405 36
  • 45 (a)
zgc:163061 35
  • 66.2 (n)
  • 69.01 (a)
zgc:163061 36
  • 57 (a)
zgc:163061 36
  • 57 (a)
Species with no ortholog for HIST1H1T:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1T Gene

Gene Tree for HIST1H1T (if available)
Gene Tree for HIST1H1T (if available)

Paralogs for HIST1H1T Gene

Paralogs for HIST1H1T Gene

Selected SIMAP similar genes for HIST1H1T Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HIST1H1T: view

Variants for HIST1H1T Gene

Sequence variations from dbSNP and Humsavar for HIST1H1T Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs198843 -- 26,110,086(+) AAGTG(A/T)GATAG upstream-variant-2KB
rs198844 - 26,108,054(+) GGCTA(A/C/G)ACCAG missense, reference
rs198845 - 26,107,562(+) CTGCT(G/T)TTGCT missense, reference
rs198846 -- 26,107,235(+) cgggg(A/G)aatga downstream-variant-500B
rs707892 -- 26,109,005(-) TAGAC(A/C)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1T Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914

Relevant External Links for HIST1H1T Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1T Gene

Disorders for HIST1H1T Gene

Relevant External Links for HIST1H1T

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HIST1H1T: view

No data available for UniProtKB/Swiss-Prot for HIST1H1T Gene

Publications for HIST1H1T Gene

  1. Structure and expression of the human gene encoding testicular H1 histone (H1t). (PMID: 1889752) Drabent B. … Doenecke D. (Gene 1991) 3 4 23
  2. Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6. (PMID: 8175896) Koppel D.A. … Grimes S.R. (J. Cell. Biochem. 1994) 2 3 4
  3. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  4. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 3 23
  5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 48

Products for HIST1H1T Gene

Sources for HIST1H1T Gene

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