Aliases for HIST1H1T Gene
External Ids for HIST1H1T Gene
Previous HGNC Symbols for HIST1H1T Gene
Previous GeneCards Identifiers for HIST1H1T Gene
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H1T Gene
HIST1H1T (Histone Cluster 1, H1t) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of DNA fragmentation factor. An important paralog of this gene is HIST1H1D.
UniProtKB/Swiss-Prot for HIST1H1T Gene
Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes (PubMed:26757249). Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination (PubMed:26757249). Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration (Probable).