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HIST1H1T Gene

protein-coding   GIFtS: 58
GCID: GC06M026107

Histone Cluster 1, H1t

(Previous names: H1 histone family, member T (testis-specific), histone 1,...)
(Previous symbol: H1FT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H1t1 2     H1t2
H1FT1 2 3 5     dJ221C16.22
H1 Histone Family, Member T (Testis-Specific)1 2     Histone H1t2
Histone 1, H1t1 2     H1T3
Testicular H1 Histone2 3     

External Ids:    HGNC: 47201   Entrez Gene: 30102   Ensembl: ENSG000001874757   OMIM: 1427125   UniProtKB: P224923   

Export aliases for HIST1H1T gene to outside databases

Previous GC identifers: GC06M026165 GC06M026215 GC06M026050


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H1T Gene:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes.
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H1T Gene:
HIST1H1T (histone cluster 1, H1t) is a protein-coding gene. Diseases associated with HIST1H1T include childhood leukemia, and hemochromatosis. An important paralog of this gene is HIST1H1E.

UniProtKB/Swiss-Prot: H1T_HUMAN, P22492
Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures

Gene Wiki entry for HIST1H1T Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H1T gene promoter:
         TBP   Elk-1   NF-YA   NRSF form 1   GCNF   NRSF form 2   TFIID   GCNF-1   GCNF-2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H1T promoter sequence
   Search Chromatin IP Primers for HIST1H1T

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H1T


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H1T Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1T gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026107:  view genomic region     (about GC identifiers)

Start:
26,107,640 bp from pter      End:
26,108,364 bp from pter
Size:
725 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H1T_HUMAN, P22492 (See protein sequence)
Recommended Name: Histone H1t  
Size: 207 amino acids; 22019 Da
Developmental stage: This histone is a testis-specific H1 variant that appears during meiosis in spermatogenesis
Secondary accessions: Q6ISI1 Q8IUE8

Explore the universe of human proteins at neXtProt for HIST1H1T: NX_P22492

Explore proteomics data for HIST1H1T at MOPED

Post-translational modifications: 

  • Phosphorylated in early spermatids (By similarity)1
  • Citrullination at Arg-58 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its
    displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell
    maintenance (By similarity)1
  • Ubiquitination2 at Lys68, Lys79
  • Modification sites at PhosphoSitePlus

  • See HIST1H1T Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005314.2  
    ENSEMBL proteins: 
     ENSP00000341214  

    HIST1H1T Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR005819 Histone_H5
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5_H15

    Graphical View of Domain Structure for InterPro Entry P22492

    ProtoNet protein and cluster: P22492

    1 Blocks protein domain: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H1T_HUMAN, P22492
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    HIST1H1T for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H1T_HUMAN, P22492
    Function: Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    HIST1H1T for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HIST1H1T:
     Lamellipodia cells 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hist1h1t):
     normal  reproductive system 

    HIST1H1T for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HIST1H1T: Hist1h1ttm1Ais Hist1h1ttm1Drab

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H1T
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H1T
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H1T

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate HIST1H1T:
    hsa-miR-1276
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H1T_HUMAN, P22492: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0000794condensed nuclear chromosome IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----

    HIST1H1T for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H1T About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    PKA Signaling0.56
    2Activation of the pre-replicative complex
    Cell cycle Start of DNA replication in early S phase0.53
    3Activation of DNA fragmentation factor
    Granzyme-A Pathway0.32
    4Packaging Of Telomere Ends
    Histone modification0.31
    5Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H1T
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1T
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H1T
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H1T

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for HIST1H1T (P224922, 3 ENSP000003412144) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000235068Q018603, ENSP000004050414I2D: score=1 STRING: ENSP00000405041
    ENSG00000206454Q018603I2D: score=1 
    ENSG00000229094Q018603I2D: score=1 
    ENSG00000230336Q018603I2D: score=1 
    ENSG00000233911Q018603I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0007339binding of sperm to zona pellucida IEA--
    GO:0030154cell differentiation IEA--

    HIST1H1T for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H1T (H1T)

    1 Novoseek inferred chemical compound relationship for HIST1H1T gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    protamine 59.8 2 12920187 (2)



    HIST1H1T for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H1T gene: 
    NM_005323.3  

    Unigene Cluster for HIST1H1T:

    Histone cluster 1, H1t
    Hs.533293  [show with all ESTs]
    Unigene Representative Sequence: NM_005323
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000338379(uc003ngj.3)
    miRNA
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    hsa-miR-1276
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HIST1H1T
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HIST1H1T
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIST1H1T
      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H1T
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H1T

    Additional mRNA sequence: 

    BC069517.1 BC130350.1 

    1 DOTS entry:

    DT.404525 

    5 AceView cDNA sequences:

    BC069517 BP369074 NM_005323 BV183498 BV198254 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H1T expression in normal human tissues (normalized intensities)      HIST1H1T embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTTAATGT
    HIST1H1T Expression
    About this image


    HIST1H1T expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Secondary Spermatocyte Seminiferous Tubules
             Long-time differentiated EBs
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
     
     Brain (Nervous System)
             Hypothalamus
     
     Inner Cell Mass (Early Embryonic Tissues)
             ES-J1
    HIST1H1T Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H1T Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533293
        Custom PCR Arrays for HIST1H1T
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H1T gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h1t1 , 5 histone cluster 1, H1t1, 5 67.32(n)1
    64.04(a)1
      13 (9.88 cM)5
    1079701  NM_010377.21  NP_034507.21 
     236958145 
    chicken
    (Gallus gallus)
    Aves HIST1H111R1 histone cluster 1, H1.11R (similar to human histone more 58.54(n)
    54.82(a)
      427896  NM_001081703.1  NP_001075172.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    74(a)
    44(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343400.1(426161-426382)
    1(257466593-257467324)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017329471 histone H1B-like 58.94(n)
    55.07(a)
      101732947  XM_004912384.1  XP_004912441.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1630611 zgc:163061 66.2(n)
    69.01(a)
      100037379  NM_001089531.1  NP_001083000.1 


    ENSEMBL Gene Tree for HIST1H1T (if available)
    TreeFam Gene Tree for HIST1H1T (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H1T gene
    HIST1H1E2  H1F02  HIST1H1D2  HIST1H1B2  HIST1H1C2  HIST1H1A2  
    6 SIMAP similar genes for HIST1H1T using alignment to 2 protein entries:     H1T_HUMAN (see all proteins):
    HIST1H1B    HIST1H1E    HIST1H1A    HIST1H1C    HIST1H1D    H1F0

    HIST1H1T for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H1T (see all 176)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs769797891,2
    C--26107185(+) TACCAC/TGGACC 1 -- ds50010--------
    rs1863483901,2
    --26107189(+) ACGGAA/CCAGGG 1 -- ds50010--------
    rs94676741,2
    F--26107265(+) agattG/Ttcaca 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1902658321,2
    --26107275(+) AAGGAA/GCCTGA 1 -- ds50010--------
    rs1828499841,2
    --26107295(+) CCCTTC/GCATGT 1 -- ds50010--------
    rs20515431,2
    C,F,A,H--26107331(-) tagatT/Actcat 1 -- ds500113Minor allele frequency- A:0.31NS EA WA NA 1202
    rs768117491,2
    C--26107363(+) ACAGGC/TGGTGG 1 -- ds50010--------
    rs1417362901,2
    C--26107389(+) TGTTCA/GCTCAC 1 -- ds50010--------
    rs1454670561,2
    --26107426(+) ACGTGC/TCATGG 1 -- ds50010--------
    rs1476868841,2
    C--26107458(+) GTGGCA/CGGGGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HIST1H1T (26107640 - 26108364 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H1T:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H1T
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H1T

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142712    OMIM disorders: --

    4 diseases for HIST1H1T:    About MalaCards
    childhood leukemia    hemochromatosis    neuroblastoma    leukemia


    HIST1H1T for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIST1H1T
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1T (2 documents)

    Export disorders for HIST1H1T gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H1T gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with HIST1H1T)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6. (PubMed id 8175896)1, 2, 3 Koppel D.A.... Grimes S.R. (J. Cell. Biochem. 1994)
    3. Structure and expression of the human gene encoding testicular H1 histone (H1t). (PubMed id 1889752)1, 2, 9 Drabent B.... Doenecke D. (Gene 1991)
    4. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PubMed id 21909110)1, 4 Wain L.V....van Duijn C.M. (Nat. Genet. 2011)
    5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    6. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. (PubMed id 19820698)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Expression of mRNA and protein of nucleoproteins during human spermiogenesis. (PubMed id 9809674)1, 9 Steger K....Bergmann M. (Mol. Hum. Reprod. 1998)
    9. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 9 Albig W.... Doenecke D. (Genomics 1997)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3010 HGNC: 4720 AceView: HIST1H1T Ensembl:ENSG00000187475 euGenes: HUgn3010
    ECgene: HIST1H1T H-InvDB: HIST1H1T

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H1T Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H1T gene:
    Search GeneIP for patents involving HIST1H1T

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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