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Aliases for HIST1H1E Gene

Aliases for HIST1H1E Gene

  • Histone Cluster 1, H1e 2 3 5
  • H1 Histone Family, Member 4 2 3
  • Histone 1, H1e 2 3
  • Histone H1s-4 3 4
  • Histone H1b 3 4
  • H1F4 3 4
  • DJ221C16.5 3
  • H1s-4 3
  • H1.4 3
  • H1E 3

External Ids for HIST1H1E Gene

Previous HGNC Symbols for HIST1H1E Gene

  • H1F4

Previous GeneCards Identifiers for HIST1H1E Gene

  • GC06P026216
  • GC06P026264
  • GC06P026099

Summaries for HIST1H1E Gene

Entrez Gene Summary for HIST1H1E Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H1E Gene

HIST1H1E (Histone Cluster 1, H1e) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Packaging Of Telomere Ends. GO annotations related to this gene include poly(A) RNA binding and chromatin DNA binding. An important paralog of this gene is HIST1H1D.

UniProtKB/Swiss-Prot for HIST1H1E Gene

  • Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Wiki entry for HIST1H1E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1E Gene

Genomics for HIST1H1E Gene

Regulatory Elements for HIST1H1E Gene

Promoters for HIST1H1E Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H1E on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H1E Gene

Chromosome:
6
Start:
26,156,331 bp from pter
End:
26,157,115 bp from pter
Size:
785 bases
Orientation:
Plus strand

Genomic View for HIST1H1E Gene

Genes around HIST1H1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1E Gene

Proteins for HIST1H1E Gene

  • Protein details for HIST1H1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10412-H14_HUMAN
    Recommended name:
    Histone H1.4
    Protein Accession:
    P10412
    Secondary Accessions:
    • Q4VB25

    Protein attributes for HIST1H1E Gene

    Size:
    219 amino acids
    Molecular mass:
    21865 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • This variant accounts for 60% of histone H1.

    Three dimensional structures from OCA and Proteopedia for HIST1H1E Gene

neXtProt entry for HIST1H1E Gene

Proteomics data for HIST1H1E Gene at MOPED

Post-translational modifications for HIST1H1E Gene

  • Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.
  • Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
  • Ubiquitination at Lys 17
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H1E Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HIST1H1E (H1E)

No data available for DME Specific Peptides for HIST1H1E Gene

Domains & Families for HIST1H1E Gene

Gene Families for HIST1H1E Gene

Protein Domains for HIST1H1E Gene

Suggested Antigen Peptide Sequences for HIST1H1E Gene

Graphical View of Domain Structure for InterPro Entry

P10412

UniProtKB/Swiss-Prot:

H14_HUMAN :
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Belongs to the histone H1/H5 family.
Domain:
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1E: view

Function for HIST1H1E Gene

Molecular function for HIST1H1E Gene

UniProtKB/Swiss-Prot Function:
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Ontology (GO) - Molecular Function for HIST1H1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031490 chromatin DNA binding IMP 15911621
genes like me logo Genes that share ontologies with HIST1H1E: view

Phenotypes for HIST1H1E Gene

genes like me logo Genes that share phenotypes with HIST1H1E: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H1E Gene

Localization for HIST1H1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1E Gene

Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H1E Gene COMPARTMENTS Subcellular localization image for HIST1H1E gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for HIST1H1E Gene

Pathways & Interactions for HIST1H1E Gene

genes like me logo Genes that share pathways with HIST1H1E: view

Pathways by source for HIST1H1E Gene

Gene Ontology (GO) - Biological Process for HIST1H1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
genes like me logo Genes that share ontologies with HIST1H1E: view

No data available for SIGNOR curated interactions for HIST1H1E Gene

Drugs & Compounds for HIST1H1E Gene

(1) Drugs for HIST1H1E Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HIST1H1E: view

Transcripts for HIST1H1E Gene

mRNA/cDNA for HIST1H1E Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1E Gene

Histone cluster 1, H1e:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1E Gene

No ASD Table

Relevant External Links for HIST1H1E Gene

GeneLoc Exon Structure for
HIST1H1E
ECgene alternative splicing isoforms for
HIST1H1E

Expression for HIST1H1E Gene

mRNA expression in normal human tissues for HIST1H1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1E Gene

This gene is overexpressed in Whole Blood (x7.3).

Protein differential expression in normal tissues from HIPED for HIST1H1E Gene

This gene is overexpressed in NK cells (28.3) and Fetal testis (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H1E Gene



SOURCE GeneReport for Unigene cluster for HIST1H1E Gene Hs.248133

genes like me logo Genes that share expression patterns with HIST1H1E: view

Protein tissue co-expression partners for HIST1H1E Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H1E Gene

Orthologs for HIST1H1E Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H1E 36
  • 100 (a)
OneToOne
LOC471881 35
  • 99.39 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HIST1H1E 35
  • 89.19 (n)
  • 98.63 (a)
HIST1H1E 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIST1H1E 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist1h1e 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 86 (a)
ManyToMany
-- 36
  • 78 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 67 (a)
ManyToMany
HIST1H111L 36
  • 75 (a)
ManyToMany
HIST1H111R 36
  • 75 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.806 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.494 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
CABZ01086354.1 36
  • 72 (a)
ManyToMany
CU457819.3 36
  • 74 (a)
ManyToMany
FP325123.1 36
  • 71 (a)
ManyToMany
histh1l 36
  • 68 (a)
ManyToMany
si:ch211-113a14.12 36
  • 71 (a)
ManyToMany
si:ch211-113a14.18 36
  • 70 (a)
ManyToMany
si:ch211-113a14.24 36
  • 70 (a)
ManyToMany
si:dkey-108k21.10 36
  • 69 (a)
ManyToMany
si:dkey-108k21.14 36
  • 69 (a)
ManyToMany
si:dkey-108k21.21 36
  • 64 (a)
ManyToMany
si:dkey-261m9.12 36
  • 70 (a)
ManyToMany
zgc:110425 36
  • 69 (a)
ManyToMany
zgc:153405 36
  • 71 (a)
ManyToMany
zgc:163061 36
  • 69 (a)
ManyToMany
zgc:163061 36
  • 69 (a)
ManyToMany
Species with no ortholog for HIST1H1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1E Gene

ENSEMBL:
Gene Tree for HIST1H1E (if available)
TreeFam:
Gene Tree for HIST1H1E (if available)

Paralogs for HIST1H1E Gene

Paralogs for HIST1H1E Gene

(7) SIMAP similar genes for HIST1H1E Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HIST1H1E: view

Variants for HIST1H1E Gene

Sequence variations from dbSNP and Humsavar for HIST1H1E Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036203 A colorectal cancer sample
VAR_049307 -
rs78302906 -- 26,154,641(+) GGCTT(G/T)TAGTT upstream-variant-2KB
rs79292047 -- 26,155,739(+) AGATT(G/T)ATGTC upstream-variant-2KB
rs140347204 -- 26,154,581(+) GAACA(A/G)TATCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1E Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914
dgv375n21 CNV Loss 19592680

Variation tolerance for HIST1H1E Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H1E Gene

HapMap Linkage Disequilibrium report
HIST1H1E
Human Gene Mutation Database (HGMD)
HIST1H1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1E Gene

Disorders for HIST1H1E Gene

Relevant External Links for HIST1H1E

Genetic Association Database (GAD)
HIST1H1E
Human Genome Epidemiology (HuGE) Navigator
HIST1H1E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H1E

No disorders were found for HIST1H1E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1E Gene

Publications for HIST1H1E Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. L3MBTL1, a histone-methylation-dependent chromatin lock. (PMID: 17540172) Trojer P. … Reinberg D. (Cell 2007) 3 23
  3. HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding. (PMID: 16127177) Daujat S. … Schneider R. (J. Biol. Chem. 2005) 3 23
  4. Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry. (PMID: 15595731) Garcia B.A. … Hunt D.F. (J. Proteome Res. 2004) 3 23
  5. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PMID: 1916825) Albig W. … Doenecke D. (Genomics 1991) 2 3

Products for HIST1H1E Gene

Sources for HIST1H1E Gene

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