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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H1E Gene

protein-coding   GIFtS: 54
GCID: GC06P026156

histone cluster 1, H1e

(Previous names: H1 histone family, member 4, histone 1, H1e )
(Previous symbol: H1F4)
 Explore 6 diseases affiliated with
HIST1H1E via our new
 Human Malady Compendium 
Biological research products
for HIST1H1E
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Histone Cluster 1, H1e1 2     Histone H1b2 3
H1F41 2 3 5     Histone H1s-42 3
H1.41 2     H1e1
H1s-41 2     H1E2
H1 Histone Family, Member 41 2     DJ221C16.51
Histone 1, H1e1 2     Histone H1.42

External Ids:    HGNC: 47181   Entrez Gene: 30082   Ensembl: ENSG000001682987   OMIM: 1422205   UniProtKB: P104123   

Export aliases for HIST1H1E gene to outside databases

Previous GC identifers: GC06P026216 GC06P026264 GC06P026099


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H1E:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two
molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp
of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between
nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and
encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a
palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H14_HUMAN, P10412
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the
chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured
fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and
DNA methylation (By similarity)

Gene Wiki entry for HIST1H1E


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H1E gene promoter:
         AML1a   Lmo2   MIF-1   CRE-BP1   AREB6   CREB   HSF2   Msx-1   TGIF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H1E promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H1E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H1E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H1E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1E gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026156:  view genomic region     (about GC identifiers)

Start:
26,156,559 bp from pter      End:
26,157,343 bp from pter
Size:
785 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H14_HUMAN, P10412 (See protein sequence)
Recommended Name: Histone H1.4  
Size: 219 amino acids; 21865 Da
Subcellular location: Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining
pattern in the nucleus
Miscellaneous: This variant accounts for 60% of histone H1
1 PDB 3D structure from and Proteopedia for HIST1H1E:
3TZD (3D)    
Secondary accessions: Q4VB25

Explore the universe of human proteins at neXtProt for HIST1H1E: NX_P10412

Post-translational modifications:

  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2
  • phase and M phase, and being dephosphorylated sharply thereafter (By similarity)1
  • Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P10412

  • HIST1H1E Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005312.1  
    ENSEMBL proteins: 
     ENSP00000307705  
    Reactome Protein details: P10412
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant HIST1H1E Protein
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    Novus Biologicals HIST1H1E Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H1E

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005634nucleus IDA17540172


    HIST1H1E for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HIST1H1E


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HIST1H1E for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005819 Histone_H5
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR005818 Histone_H1/H5

    Graphical View of Domain Structure for InterPro Entry P10412

    ProtoNet protein and cluster: P10412

    1 Blocks protein family: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H14_HUMAN, P10412
    Domain: The C-terminal domain is required for high-affinity binding to chromatin (By similarity)
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: H14_HUMAN, P10412
    Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the
    chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured
    fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and
    DNA methylation (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H1E
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H1E:
    hsa-miR-146a* hsa-miR-1276
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0005515protein binding IPI15469825


    HIST1H1E for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for HIST1H1E: Hist1h1etm2Ais Hist1h1etm1Ais
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hist1h1e):
     cardiovascular system  embryogenesis  growth/size  hematopoietic system  immune system 
     limbs/digits/tail  mortality/aging  nervous system  normal  reproductive system 

    HIST1H1E for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor1.00
    Granzyme-A Pathway0.32
    Apoptosis induced DNA fragmentation1.00
    2Cell cycle_Start of DNA replication in early S phase
    Cell cycle_Start of DNA replication in early S phase1.00
    Cell cycle Start of DNA replication in early S phase0.98
    3Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase1.00
    Cell cycle_Chromosome condensation in prometaphase1.00
    4Signaling events mediated by HDAC Class III
    Signaling events mediated by HDAC Class III1.00
    5Apoptotic cleavage of cellular proteins
    Apoptotic execution phase0.73

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for HIST1H1E
        Histone modification
    Cell cycle Start of DNA replication in early S phase
    Cell cycle Chromosome condensation in prometaphase

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H1E
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1E
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase

    1 BioSystems Pathway for HIST1H1E 
        Signaling events mediated by HDAC Class III

    4        Reactome Pathways for HIST1H1E
        Activation of DNA fragmentation factor
    Apoptosis induced DNA fragmentation
    Apoptotic execution phase
    Apoptosis



    HIST1H1E for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIST1H1E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/36 Interacting proteins for HIST1H1E (P104121, 2, 3 ENSP000003077054) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--
    GO:0016584nucleosome positioning IEA--


    HIST1H1E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIST1H1E for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H1E
    1 Novoseek chemical compound relationship for HIST1H1E gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 54.3 1 18450745 (1)

    Search CenterWatch for drugs/clinical trials and news about HIST1H1E / H14 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H1E gene: 
    NM_005321.2  

    Unigene Cluster for HIST1H1E:

    Histone cluster 1, H1e
    Hs.248133  [show with all ESTs]
    Unigene Representative Sequence: BU603483
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304218(uc003ngq.3)

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H1E:
    hsa-miR-146a* hsa-miR-1276
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H1E
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H1E

    Additional cDNA sequence: 

    AK313681.1 BC055095.1 BC096168.1 BC096169.1 BC096170.1 BC099632.1 EF065554.1 EF065555.1 

    2 DOTS entries:

    DT.101979398  DT.75165589 

    4 AceView cDNA sequences:

    NM_005321 BU603483 BC055095 BX281174 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H1E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HIST1H1E Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H1E

    SOURCE GeneReport for Unigene cluster: Hs.248133
        SABiosciences Custom PCR Arrays for HIST1H1E
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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H1E gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves H101_CHICK6
    F1NME1_CHICK6
    (see all 5)
    Uncharacterized protein
    (see all 5)
    72(a)
    72(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    1(50026207-50026866)
    1(50050557-50051216)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    --
    88(a)
    63(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343400.1(426161-426382)
    GL343279.1(541498-542142)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8062 Xenopus laevis transcribed sequence with weak similarity more 79.08(n)    BJ619437.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM402151.12   -- 79.51(n)   321154  BM402151.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His1:CG338136
    His1:CG338556
    (see all 23)
    His1:CG33855
    (see all 23)
    28(a)
    28(a)
    (see all 23)
    many ↔ many
    many ↔ many
    (see all 23)
    2L(21451177-21452074)
    2L(21521741-21522638)
    worm
    (Caenorhabditis elegans)
    Secernentea hil-16
    Histone H1.X
    17(a)
    possible ortholog
    V(14949760-14952775)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons HIS1-36
    AT2G306206
    (see all 3)
    histone H1.2
    (see all 3)
    20(a)
    16(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    2(7845923-7846884)
    2(13044931-13046663)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    (see all 4)
    histone H1, putative, expressed
    (see all 4)
    25(a)
    18(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    4(9984198-9985211)
    6(1641215-1642801)


    ENSEMBL Gene Tree for HIST1H1E (if available)
    TreeFam Gene Tree for HIST1H1E (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H1E gene
    HIST1H1T2  HIST1H1D2  H1F02  HIST1H1B2  HIST1H1C2  H1FOO2  H1FX2  HIST1H1A2  
    7 SIMAP similar genes for HIST1H1E using alignment to 3 protein entries:     H14_HUMAN (see all proteins):
    HIST1H1C    HIST1H1D    HIST1H1B    HIST1H1A    HIST1H1T    H1FX
    H1F0

    HIST1H1E for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/123 NCBI SNPs in HIST1H1E are shown (see all 123    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs774759391,2
    C,F,--26154616(+) CATTGA/GTAATT 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1906041171,2
    --26154698(+) ATTCTA/CTATTC 1 -- us2k10--------
    rs1467427011,2
    --26154792(+) AATCAA/GCCACG 1 -- us2k10--------
    rs1403472041,2
    --26154809(+) GAACAA/GTATCA 1 -- us2k10--------
    rs783029061,2
    C,--26154869(+) GGCTTG/TTAGTT 1 -- us2k10--------
    rs2017764861,2
    C--26154917(+) AAATTC/TTTTTT 1 -- us2k10--------
    rs1828539121,2
    --26155165(+) CCCGTC/GTCGGC 1 -- us2k10--------
    rs1883234151,2
    --26155231(+) TCTTTA/TGGTTG 1 -- us2k10--------
    rs1921613921,2
    --26155292(+) AAGAAA/GTTCAC 1 -- us2k10--------
    rs1828576921,2
    --26155477(+) TTGAAA/TCCATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H1E (26156559 - 26157343 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HIST1H1E
         1 CNV: 51865

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HIST1H1E for disorders           About GeneDecksing

    OMIM gene information: 142220    OMIM disorders: --

    6 diseases for HIST1H1E:    About MalaCards
    progressive supranuclear palsy    supranuclear palsy    x inactivation    pancreatic cancer
    pancreatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for HIST1H1E:
    Progressive supranuclear palsy
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1E (1 document)

    Export disorders for HIST1H1E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H1E gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with HIST1H1E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2, 3 Albig W....Doenecke D. (1991)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. (PubMed id 15469825)1, 2 Vaquero A....Reinberg D. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PubMed id 10997781)1, 2 Parseghian M.H....Hamkalo B.A. (2000)
    8. Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b. (PubMed id 3782055)1, 2 Ohe Y.... Iwai K. (1986)
    9. HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding. (PubMed id 16127177)1, 9 Daujat S....Schneider R. (2005)
    10. L3MBTL1, a histone-methylation-dependent chromatin lock. (PubMed id 17540172)1, 9 Trojer P....Reinberg D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3008 HGNC: 4718 AceView: HIST1H1E Ensembl:ENSG00000168298 euGenes: HUgn3008
    ECgene: HIST1H1E H-InvDB: HIST1H1E

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H1E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H1E gene:
    Search GeneIP for patents involving HIST1H1E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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