Aliases for HIST1H1E Gene
Aliases for HIST1H1E Gene
External Ids for HIST1H1E Gene
- HGNC: 4718
- Entrez Gene: 3008
- Ensembl: ENSG00000168298
- OMIM: 142220
- UniProtKB: P10412
Previous HGNC Symbols for HIST1H1E Gene
- H1F4
Previous GeneCards Identifiers for HIST1H1E Gene
- GC06P026216
- GC06P026264
- GC06P026099
Summaries for HIST1H1E Gene
-
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H1E Gene
HIST1H1E (Histone Cluster 1 H1 Family Member E) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Apoptosis induced DNA fragmentation. GO annotations related to this gene include poly(A) RNA binding and chromatin DNA binding. An important paralog of this gene is HIST1H1B.
UniProtKB/Swiss-Prot for HIST1H1E Gene
-
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1E Gene
Genomics for HIST1H1E Gene
Regulatory Elements for HIST1H1E Gene
Enhancers for HIST1H1E Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIST1H1E on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIST1H1E gene promoter:
Regulatory Element Products
Genomic Location for HIST1H1E Gene
- Chromosome:
- 6
- Start:
- 26,156,331 bp from pter
- End:
- 26,157,115 bp from pter
- Size:
- 785 bases
- Orientation:
- Plus strand
Genomic View for HIST1H1E Gene
Genes around HIST1H1E on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
HIST1H1E Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H1E Gene
Proteins for HIST1H1E Gene
-
Protein details for HIST1H1E Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P10412-H14_HUMAN
- Recommended name:
- Histone H1.4
- Protein Accession:
- P10412
- Q4VB25
Protein attributes for HIST1H1E Gene
- Size:
- 219 amino acids
- Molecular mass:
- 21865 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- This variant accounts for 60% of histone H1.
Protein Expression for HIST1H1E Gene
Post-translational modifications for HIST1H1E Gene
- Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT1.
- ADP-ribosylated on Ser-150 in response to DNA damage.
- Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
- H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
- Ubiquitination at isoforms=17
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H1E Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore top HIST1H1E Antibody
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H1E
- Cell Signaling Technology (CST) Antibodies for HIST1H1E (H1E)
- Novus Biologicals Antibodies for HIST1H1E
-
Abcam antibodies for HIST1H1E
- Invitrogen Antibodies for HIST1H1E
- GeneTex HIST1H1E antibody for HIST1H1E
Protein Products
- EMD Millipore Purified and/or Recombinant HIST1H1E Protein
-
OriGene Purified Proteins for HIST1H1E
- Search Origene for MassSpec and Protein Over-expression Lysates for HIST1H1E
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- Search GeneTex for Proteins for HIST1H1E
-
Abcam proteins for HIST1H1E
Assay Products
No data available for DME Specific Peptides for HIST1H1E Gene
Domains & Families for HIST1H1E Gene
Gene Families for HIST1H1E Gene
- HGNC:
Protein Domains for HIST1H1E Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H1E Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P10412UniProtKB/Swiss-Prot:
H14_HUMAN :- The C-terminal domain is required for high-affinity binding to chromatin.
- Belongs to the histone H1/H5 family.
- Domain:
-
- The C-terminal domain is required for high-affinity binding to chromatin.
- Family:
-
- Belongs to the histone H1/H5 family.
Function for HIST1H1E Gene
Molecular function for HIST1H1E Gene
- UniProtKB/Swiss-Prot Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003690 | double-stranded DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IDA | 22681889 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 15469825 |
Phenotypes for HIST1H1E Gene
- GenomeRNAi human phenotypes for HIST1H1E:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H1E gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1E gene
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CRISPR Products
-
OriGene CRISPR knockouts for HIST1H1E
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H1E
- GenScript: Design CRISPR guide RNA sequences for HIST1H1E
miRNA for HIST1H1E Gene
- miRTarBase miRNAs that target HIST1H1E
-
- hsa-mir-34a-5p (MIRT025303)
- hsa-mir-1180-3p (MIRT035933)
- hsa-mir-877-3p (MIRT036815)
- hsa-mir-744-5p (MIRT037534)
- hsa-mir-455-3p (MIRT037853)
- hsa-mir-423-5p (MIRT038119)
- hsa-let-7g-3p (MIRT038661)
- hsa-mir-652-3p (MIRT039548)
- hsa-mir-193b-3p (MIRT041423)
- hsa-mir-331-3p (MIRT043395)
- hsa-mir-320a (MIRT044538)
- hsa-mir-186-5p (MIRT045006)
- hsa-mir-181b-5p (MIRT047253)
- hsa-mir-92a-3p (MIRT049232)
- hsa-mir-3147 (MIRT218415)
- hsa-mir-4263 (MIRT218416)
- hsa-mir-3620-5p (MIRT218418)
- hsa-mir-1587 (MIRT218421)
- hsa-mir-4674 (MIRT218422)
- hsa-mir-6792-5p (MIRT218424)
- hsa-mir-6815-3p (MIRT218425)
- hsa-mir-146a-3p (MIRT317223)
- hsa-mir-760 (MIRT317224)
- hsa-mir-1276 (MIRT317225)
- hsa-mir-3940-5p (MIRT317228)
- hsa-mir-4507 (MIRT317229)
- hsa-mir-8057 (MIRT317231)
- hsa-mir-5693 (MIRT523280)
- hsa-mir-6839-3p (MIRT523281)
- hsa-mir-4425 (MIRT523282)
- hsa-mir-6748-5p (MIRT523283)
- hsa-mir-6769b-5p (MIRT523284)
- hsa-mir-6769a-5p (MIRT523285)
- hsa-mir-4483 (MIRT523286)
- hsa-mir-1293 (MIRT523287)
- hsa-mir-6766-5p (MIRT523288)
- hsa-mir-6756-5p (MIRT523289)
- hsa-mir-6745 (MIRT523290)
- hsa-mir-363-5p (MIRT523291)
- hsa-mir-27a-5p (MIRT523292)
- hsa-mir-6822-3p (MIRT523293)
- hsa-mir-4766-5p (MIRT523294)
- hsa-mir-6786-5p (MIRT523295)
miRNA Products
- Search ViGene Biosciences for HIST1H1E
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H1E
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-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1E gene
Clone Products
-
OriGene ORF clones in human for HIST1H1E
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products
-
Horizon Cell Lines for HIST1H1E
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H1E gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H1E gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H1E Gene
Localization for HIST1H1E Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1E Gene
- Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining pattern in the nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000788 | nuclear nucleosome | IEA | -- |
| GO:0005634 | nucleus | IDA | 17540172 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005720 | nuclear heterochromatin | IDA | 15911621 |
Pathways & Interactions for HIST1H1E Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis induced DNA fragmentation | ||
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
| 3 | Cellular Senescence | ||
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | Chromatin Regulation / Acetylation | ||
Pathways by source for HIST1H1E Gene
1 Cell Signaling Technology pathway for HIST1H1E Gene
2 BioSystems pathways for HIST1H1E Gene
9 Reactome pathways for HIST1H1E Gene
2 GeneGo (Thomson Reuters) pathways for HIST1H1E Gene
2 Qiagen pathways for HIST1H1E Gene
Interacting Proteins for HIST1H1E Gene
Selected Interacting proteins:
P10412-H14_HUMAN
ENSP00000307705
for HIST1H1E Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006334 | nucleosome assembly | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0016584 | nucleosome positioning | IEA | -- |
| GO:0080182 | histone H3-K4 trimethylation | IEA | -- |
No data available for SIGNOR curated interactions for HIST1H1E Gene
Transcripts for HIST1H1E Gene
mRNA/cDNA for HIST1H1E Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H1E Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H1E
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H1E
- GenScript: Design CRISPR guide RNA sequences for HIST1H1E
miRNA Products
- Search ViGene Biosciences for HIST1H1E
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H1E
- Browse OriGene Inhibitory RNA Products For HIST1H1E
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1E gene
Clone Products
-
OriGene ORF clones in human for HIST1H1E
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIST1H1E
Flow Cytometry Products
Expression for HIST1H1E Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Ectoderm (Nervous System)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for HIST1H1E Gene
This gene is overexpressed in Whole Blood (x7.3).
This gene is overexpressed in NK cells (28.3) and Fetal testis (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H1E Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HIST1H1E Gene:
HIST1H1ESOURCE GeneReport for Unigene cluster for HIST1H1E Gene:
Hs.248133Evidence on tissue expression from TISSUES for HIST1H1E Gene
- Liver(4.7)
- Spleen(4.3)
- Stomach(3.7)
- Intestine(3.5)
- Muscle(3.5)
- Nervous system(3.3)
- Kidney(3.1)
- Heart(3)
Primer Products
-
OriGene qPCR primer pairs and template standards for HIST1H1E
-
OriGene qPCR primer pairs for HIST1H1E
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H1E Gene
Orthologs for HIST1H1E Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIST1H1E 35 |
|
OneToOne | |
| LOC471881 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | HIST1H1E 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hist1h1e 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HIST1H1E 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | HIST1H111L 35 |
|
ManyToMany | |
| HIST1H111R 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.494 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.806 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | CU457819.3 35 |
|
ManyToMany | |
| CABZ01086354.1 35 |
|
ManyToMany | |||
| FP325123.1 35 |
|
ManyToMany | |||
| si:ch211-113a14.12 35 |
|
ManyToMany | |||
| zgc:153405 35 |
|
ManyToMany | |||
| si:ch211-113a14.18 35 |
|
ManyToMany | |||
| si:ch211-113a14.24 35 |
|
ManyToMany | |||
| si:dkey-261m9.12 35 |
|
ManyToMany | |||
| si:dkey-108k21.10 35 |
|
ManyToMany | |||
| si:dkey-108k21.14 35 |
|
ManyToMany | |||
| zgc:110425 35 |
|
ManyToMany | |||
| zgc:163061 35 35 |
|
ManyToMany | |||
| histh1l 35 |
|
ManyToMany | |||
| si:dkey-108k21.21 35 |
|
ManyToMany | |||
| -- 34 |
|
- Species where no ortholog for HIST1H1E was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST1H1E Gene
Variants for HIST1H1E Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs768731472 | A colorectal cancer sample | 26,156,773(+) | CAAGG(C/T)CAAGA | upstream-variant-2KB, reference, missense | |
| rs1002598295 | -- | 26,157,589(+) | TTCAA(A/G)TGCTT | downstream-variant-500B, upstream-variant-2KB | |
| rs1003595309 | -- | 26,157,128(+) | CAGTA(A/G)AAGAG | downstream-variant-500B, upstream-variant-2KB | |
| rs1003674986 | -- | 26,155,004(+) | CTTTT(A/G)GTTGG | upstream-variant-2KB | |
| rs1003944586 | -- | 26,156,711(+) | AAACT(C/G)AACAA | upstream-variant-2KB, reference, synonymous-codon |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv375n21 | CNV | loss | 19592680 |
| dgv5926n100 | CNV | gain | 25217958 |
| esv3608394 | CNV | loss | 21293372 |
| esv3608395 | CNV | gain | 21293372 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
Residual Variation Intolerance Score:
18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.29;
40.94% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIST1H1E Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1E Gene
Disorders for HIST1H1E Gene
Relevant External Links for HIST1H1E
No disorders were found for HIST1H1E Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1E Gene
Publications for HIST1H1E Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PMID: 1916825) Albig W. … Doenecke D. (Genomics 1991) 2 3 4 64
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
- L3MBTL1, a histone-methylation-dependent chromatin lock. (PMID: 17540172) Trojer P. … Reinberg D. (Cell 2007) 3 22 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
Products for HIST1H1E Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H1E Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer