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HIST1H1E Gene

protein-coding   GIFtS: 59
GCID: GC06P026156

Histone Cluster 1, H1e

(Previous names: H1 histone family, member 4, histone 1, H1e)
(Previous symbol: H1F4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H1e1 2     H1.42
H1F41 2 3 5     H1E2
H1 Histone Family, Member 41 2     H1s-42
Histone 1, H1e1 2     dJ221C16.52
Histone H1b2 3     Histone H1.42
Histone H1s-42 3     

External Ids:    HGNC: 47181   Entrez Gene: 30082   Ensembl: ENSG000001682987   OMIM: 1422205   UniProtKB: P104123   

Export aliases for HIST1H1E gene to outside databases

Previous GC identifers: GC06P026216 GC06P026264 GC06P026099


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H1E Gene:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes.
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H1E Gene:
HIST1H1E (histone cluster 1, H1e) is a protein-coding gene. Diseases associated with HIST1H1E include progressive supranuclear palsy, and breast and colorectal cancer. An important paralog of this gene is HIST1H1T.

UniProtKB/Swiss-Prot: H14_HUMAN, P10412
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
nucleosome spacing and DNA methylation (By similarity)

Gene Wiki entry for HIST1H1E Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H1E gene promoter:
         AML1a   Lmo2   MIF-1   CRE-BP1   AREB6   CREB   HSF2   Msx-1   TGIF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H1E promoter sequence
   Search Chromatin IP Primers for HIST1H1E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H1E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H1E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1E gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P026156:  view genomic region     (about GC identifiers)

Start:
26,156,559 bp from pter      End:
26,157,343 bp from pter
Size:
785 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H14_HUMAN, P10412 (See protein sequence)
Recommended Name: Histone H1.4  
Size: 219 amino acids; 21865 Da
Miscellaneous: This variant accounts for 60% of histone H1
1 PDB 3D structure from and Proteopedia for HIST1H1E:
3TZD (3D)    
Secondary accessions: Q4VB25

Explore the universe of human proteins at neXtProt for HIST1H1E: NX_P10412

Explore proteomics data for HIST1H1E at MOPED

Post-translational modifications: 

  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late
    G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity)1
  • Acetylated at Lys-26. Deacetylated at Lys-26 by SIRT11
  • Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its
    displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell
    maintenance (By similarity)1
  • Ubiquitination2 at Lys17, Lys34, Lys46, Lys63, Lys64, Lys75, Lys85, Lys90, Lys97, Lys106
  • Modification sites at PhosphoSitePlus

  • See HIST1H1E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005312.1  
    ENSEMBL proteins: 
     ENSP00000307705  
    Reactome Protein details: P10412

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR005819 Histone_H5
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5_H15

    Graphical View of Domain Structure for InterPro Entry P10412

    ProtoNet protein and cluster: P10412

    1 Blocks protein domain: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H14_HUMAN, P10412
    Domain: The C-terminal domain is required for high-affinity binding to chromatin (By similarity)
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    HIST1H1E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H14_HUMAN, P10412
    Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
    the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
    structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
    nucleosome spacing and DNA methylation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI15469825
    GO:0044822poly(A) RNA binding IDA--
         
    HIST1H1E for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hist1h1e):
     cardiovascular system  embryogenesis  growth/size/body  hematopoietic system  immune system 
     limbs/digits/tail  mortality/aging  nervous system  normal  reproductive system 

    HIST1H1E for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HIST1H1E: Hist1h1etm2Ais Hist1h1etm1Ais

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H1E
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H1E

    miRNA
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    miRTarBase miRNAs that target HIST1H1E:
    hsa-mir-92a-3p (MIRT049232), hsa-mir-193b-3p (MIRT041423), hsa-mir-320a (MIRT044538), hsa-mir-423-5p (MIRT038119), hsa-mir-331-3p (MIRT043395), hsa-mir-1180-3p (MIRT035933), hsa-mir-455-3p (MIRT037853), hsa-mir-181b-5p (MIRT047253), hsa-mir-34a-5p (MIRT025303), hsa-mir-186-5p (MIRT045006), hsa-let-7g-3p (MIRT038661), hsa-mir-652-3p (MIRT039548), hsa-mir-877-3p (MIRT036815), hsa-mir-744-5p (MIRT037534)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H14_HUMAN, P10412: Nucleus. Chromosome. Note=Mainly localizes in heterochromatin. Dysplays a punctuate staining
    pattern in the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IDA17540172

    HIST1H1E for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H1E About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor0.32
    Apoptosis induced DNA fragmentation0.00
    Granzyme-A Pathway0.32
    2Packaging Of Telomere Ends
    DNA Damage/Telomere Stress Induced Senescence0.65
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)0.00
    Histone modification0.31
    3Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    4Apoptotic cleavage of cellular proteins
    Apoptotic execution phase0.74
    5Activation of cAMP-Dependent PKA
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H1E
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1E
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase

    1 BioSystems Pathway for HIST1H1E
        Signaling events mediated by HDAC Class III

    2 Reactome Pathways for HIST1H1E
        Activation of DNA fragmentation factor
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)



    HIST1H1E for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H1E
    Interactions:

        GeneGlobe Interaction Network for HIST1H1E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H1E (P104121, 2, 3 ENSP000003077054) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4LP628053, ENSP000003482584I2D: score=1 STRING: ENSP00000348258
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0016584nucleosome positioning IEA--

    HIST1H1E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H1E (H14)

    1 Novoseek inferred chemical compound relationship for HIST1H1E gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 54.3 1 18450745 (1)



    HIST1H1E for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H1E gene: 
    NM_005321.2  

    Unigene Cluster for HIST1H1E:

    Histone cluster 1, H1e
    Hs.248133  [show with all ESTs]
    Unigene Representative Sequence: BU603483
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304218(uc003ngq.3)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H1E
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H1E

    Additional mRNA sequence: 

    AK313681.1 BC055095.1 BC096168.1 BC096169.1 BC096170.1 BC099632.1 EF065554.1 EF065555.1 

    2 DOTS entries:

    DT.101979398  DT.75165589 

    4 AceView cDNA sequences:

    NM_005321 BU603483 BC055095 BX281174 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H1E expression in normal human tissues (normalized intensities)      HIST1H1E embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H1E Expression
    About this image


    HIST1H1E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Ectoderm (Nervous System)
             Neural ectoderm cells
     
     Neural Tube (Nervous System)
             Floor plate-like cells
     
     Eye (Sensory Organs)
             Retina
    HIST1H1E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H1E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.248133
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H1E gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h1e5 histone cluster 1, H1e   --   13 (9.83 cM) 23621755 
    chicken
    (Gallus gallus)
    Aves HIST1H111L6
    HIST1H111R6
    (see all 3)
    Gallus gallus histone cluster 1, H1.11L (similar t...
    Gallus gallus histone cluster 1, H1.11R (similar t...
    (see all 3)
    75(a)
    75(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(48025516-48026285)
    1(48033617-48034276)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.8062 Xenopus laevis transcribed sequence with weak similarity more 79.08(n)    BJ619437.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM402151.12   -- 79.51(n)   321154  BM402151.1 


    ENSEMBL Gene Tree for HIST1H1E (if available)
    TreeFam Gene Tree for HIST1H1E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H1E gene
    HIST1H1T2  H1F02  HIST1H1D2  HIST1H1B2  HIST1H1C2  HIST1H1A2  
    7 SIMAP similar genes for HIST1H1E using alignment to 3 protein entries:     H14_HUMAN (see all proteins):
    HIST1H1C    HIST1H1D    HIST1H1B    HIST1H1A    HIST1H1T    H1FX
    H1F0

    HIST1H1E for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H1E (see all 24)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362034
    A colorectal cancer sample4--see VAR_0362032 A V mis40--------
    rs774759391,2
    C,F--26154616(+) CATTGA/GTAATT 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1906041171,2
    --26154698(+) ATTCTA/CTATTC 1 -- us2k10--------
    rs1467427011,2
    C--26154792(+) AATCAA/GCCACG 1 -- us2k10--------
    rs1403472041,2
    C--26154809(+) GAACAA/GTATCA 1 -- us2k10--------
    rs783029061,2
    C--26154869(+) GGCTTG/TTAGTT 1 -- us2k10--------
    rs2017764861,2
    C--26154917(+) AAATTC/TTTTTT 1 -- us2k10--------
    rs1828539121,2
    --26155165(+) CCCGTC/GTCGGC 1 -- us2k10--------
    rs1883234151,2
    --26155231(+) TCTTTA/TGGTTG 1 -- us2k10--------
    rs1921613921,2
    --26155292(+) AAGAAA/GTTCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIST1H1E (26156559 - 26157343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H1E:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv375n21CNV Loss19592680
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H1E
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142220    OMIM disorders: --

    10 diseases for HIST1H1E:    About MalaCards
    progressive supranuclear palsy    breast and colorectal cancer    pancreatic cancer    pancreatitis
    multiple myeloma    hiv-1    myeloma    retinitis
    colorectal cancer    hepatitis

    1 disease from the University of Copenhagen DISEASES database for HIST1H1E:
    Progressive supranuclear palsy

    HIST1H1E for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIST1H1E
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1E (1 document)

    Export disorders for HIST1H1E gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H1E gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with HIST1H1E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2, 3 Albig W.... Doenecke D. (Genomics 1991)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. (PubMed id 15469825)1, 2 Vaquero A....Reinberg D. (Mol. Cell 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PubMed id 10997781)1, 2 Parseghian M.H.... Hamkalo B.A. (Chromosome Res. 2000)
    9. Human spleen histone H1. Isolation and amino acid sequence of a main variant, H1b. (PubMed id 3782055)1, 2 Ohe Y.... Iwai K. (J. Biochem. 1986)
    10. HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding. (PubMed id 16127177)1, 9 Daujat S....Schneider R. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3008 HGNC: 4718 AceView: HIST1H1E Ensembl:ENSG00000168298 euGenes: HUgn3008
    ECgene: HIST1H1E H-InvDB: HIST1H1E

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST1H1E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HIST1H1E gene:
    Search GeneIP for patents involving HIST1H1E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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