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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H1D Gene

protein-coding   GIFtS: 56
GCID: GC06M026234

histone cluster 1, H1d

(Previous names: H1 histone family, member 3, histone 1, H1d )
(Previous symbol: H1F3)
 Explore 6 diseases affiliated with
HIST1H1D via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H1D    

Aliases
for HIST1H1D gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H1d1 2     Histone H1c2 3
H1F31 2 3 5     Histone H1s-22 3
H1.31 2     H1d1
H1s-21 2     H1D2
H1 Histone Family, Member 31 2     Histone H1.32
Histone 1, H1d1 2     

External Ids:    HGNC: 47171   Entrez Gene: 30072   Ensembl: ENSG000001245757   OMIM: 1422105   UniProtKB: P164023   

Export aliases for HIST1H1D gene to outside databases

Previous GC identifers: GC06M026291 GC06M026118 GC06M026342 GC06M026177


Summaries
for HIST1H1D gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H1D:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two
molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp
of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between
nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and
encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a
palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H13_HUMAN, P16402
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the
chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured
fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and
DNA methylation (By similarity)

Gene Wiki entry for HIST1H1D


Genomic Views
for HIST1H1D gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H1D gene promoter:
         SRF   GR   SRF (504 AA)   GR-beta   AREB6   E2F-1   E2F   ARP-1   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H1D promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H1D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H1D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p21.3

HIST1H1D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1D gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026234:  view genomic region     (about GC identifiers)

Start:
 26,234,440 bp from pter      End:
 26,235,216 bp from pter
Size:
 777 bases      Orientation:
 minus strand

Proteins
for HIST1H1D gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H13_HUMAN, P16402 (See protein sequence)
Recommended Name: Histone H1.3  
Size: 221 amino acids; 22350 Da
Subcellular location: Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in euchromatin.
According to PubMed:10997781 is associated with inactive chromatin
Secondary accessions: B2R751 Q2M2I2

Explore the universe of human proteins at neXtProt for HIST1H1D: NX_P16402

Post-translational modifications:

  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2
    • phase and M phase, and being dephosphorylated sharply thereafter (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16402

    • HIST1H1D Protein expression data from MOPED and PaxDb:    About this image 
    HIST1H1D Protein Expression
    REFSEQ proteins: NP_005311.1  
    ENSEMBL proteins: 
     ENSP00000244534  
    Reactome Protein details: P16402
    Human Recombinant Protein Products for HIST1H1D: 
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    OriGene Protein Over-expression Lysate: HIST1H1D
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    Novus Biologicals HIST1H1D Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H1D

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0000790nuclear chromatin IDA19882353

    HIST1H1D for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HIST1H1D

    Protein Domains /
    Families
    for HIST1H1D gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H1D for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005819 Histone_H5
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR005818 Histone_H1/H5

    Graphical View of Domain Structure for InterPro Entry P16402

    ProtoNet protein and cluster: P16402

    1 Blocks protein family: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H13_HUMAN, P16402
    Domain: The C-terminal domain is required for high-affinity binding to chromatin (By similarity)
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    Function
    for HIST1H1D gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H13_HUMAN, P16402
    Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the
    chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured
    fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and
    DNA methylation (By similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0005515protein binding ----
         
    HIST1H1D for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hist1h1d):
     cardiovascular system  embryogenesis  growth/size  hematopoietic system  immune system 
     limbs/digits/tail  mortality/aging  nervous system  normal  reproductive system 

    HIST1H1D for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for HIST1H1D: Hist1h1dtm1Mkk Hist1h1dtm2Ais Hist1h1dtm1Ais
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HIST1H1D 

    miRNA
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    hsa-miR-146a* hsa-miR-1276 hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H1D (see all 7)
    OriGene shRNA RFP: HIST1H1D
    OriGene siRNA: HIST1H1D
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    Sirion Biotech Custom design and validation of potent shRNA sequences against HIST1H1D 

    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1D


    Pathways & Interactions
    for HIST1H1D gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of DNA fragmentation factor
    		Activation of DNA fragmentation factor1.00
    		Granzyme-A Pathway0.32
    		Apoptosis induced DNA fragmentation1.00
    2Cell cycle_Start of DNA replication in early S phase
    		Cell cycle_Start of DNA replication in early S phase1.00
    		Cell cycle Start of DNA replication in early S phase0.98
    3Cell cycle Chromosome condensation in prometaphase
    		Cell cycle Chromosome condensation in prometaphase1.00
    		Cell cycle_Chromosome condensation in prometaphase1.00
    4Apoptotic cleavage of cellular proteins
    		Apoptotic execution phase0.73
    5Activation of cAMP-Dependent PKA
    		PKA Signaling0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for HIST1H1D
        Histone modification
    Cell cycle Start of DNA replication in early S phase
    Cell cycle Chromosome condensation in prometaphase

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H1D
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1D
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase

    4        Reactome Pathways for HIST1H1D
        Activation of DNA fragmentation factor
    Apoptosis induced DNA fragmentation
    Apoptotic execution phase
    Apoptosis



    HIST1H1D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H1D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/93 Interacting proteins for HIST1H1D (P164022, 3 ENSP000002445344) via UniProtKB, MINT, STRING, and/or I2D (see all 93)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMNAP025452, 3MINT-7899812 I2D: score=1 
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=1 STRING: ENSP00000238081
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    NOP56O005673, ENSP000003705894I2D: score=1 STRING: ENSP00000370589
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--
    GO:0016584nucleosome positioning ----

    HIST1H1D for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H1D gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H1D
    Search CenterWatch for drugs/clinical trials and news about HIST1H1D / H13 

    Transcripts
    for HIST1H1D gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H1D gene: 
    NM_005320.2  

    Unigene Cluster for HIST1H1D:

    Histone cluster 1, H1d
    Hs.136857  [show with all ESTs]
    Unigene Representative Sequence: NM_005320
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244534(uc003nhd.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H1D
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H1D:
    hsa-miR-146a* hsa-miR-1276 hsa-miR-1293
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H1D (see all 7)
    OriGene shRNA RFP: HIST1H1D
    OriGene siRNA: HIST1H1D
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H1D
    Sirion Biotech Custom design and validation of potent shRNA sequences against HIST1H1D 
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H1D

    Additional cDNA sequence: 

    AK312845.1 BC104874.1 BC111971.1 

    1 DOTS entry:

    DT.439911 

    6 AceView cDNA sequences:

    BX107129 NM_005320 BG943891 AA749093 AA767038 BG230976 

    GeneLoc Exon Structure


    Expression
    for HIST1H1D gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H1D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCGGAGACTG
    HIST1H1D Expression
    About this image

    HIST1H1D expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainHypothalamusBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIST1H1D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H1D

    SOURCE GeneReport for Unigene cluster: Hs.136857
        SABiosciences Custom PCR Arrays for HIST1H1D
    Primer
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1D

    Orthologs
    for HIST1H1D gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H1D gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves H101_CHICK6
    F1NPJ2_CHICK6
    (see all 5)    		 Uncharacterized protein
    (see all 5)    		 68(a)
    68(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 1(50026207-50026866)
    1(49946004-49946660)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 4)    		 --
    		 88(a)
    61(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 GL343400.1(426161-426382)
    GL343279.1(541498-542142)
    zebrafish
    (Danio rerio)    		 Actinopterygii CR354435.46
    histh1l6
    (see all 15)    		 histone H1 like
    (see all 15)    		 66(a)
    66(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 25(37376502-37377026)
    5(29077507-29078900)
    fruit fly
    (Drosophila melanogaster)    		 Insecta His1:CG338526
    His1:CG338496
    (see all 23)    		 His1:CG33849
    (see all 23)    		 29(a)
    29(a)
    (see all 23)    		 many ↔ many
    many ↔ many
    (see all 23)    		 2L(21516898-21517795)
    2L(21511853-21512750)
    worm
    (Caenorhabditis elegans)    		 Secernentea hil-16
    		 Histone H1.X
    		 16(a)
    		 possible ortholog
    		 V(14949760-14952775)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HIS1-36
    AT1G067606
    (see all 3)    		 histone H1.1
    (see all 3)    		 20(a)
    16(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2(7845923-7846884)
    1(2076504-2077698)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 histone H1, putative, expressed
    (see all 4)    		 23(a)
    17(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 4(9984198-9985211)
    6(1641215-1642801)


    ENSEMBL Gene Tree for HIST1H1D (if available)
    TreeFam Gene Tree for HIST1H1D (if available) 

    Paralogs
    for HIST1H1D gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H1D gene
    HIST1H1T2  HIST1H1E2  H1F02  HIST1H1B2  HIST1H1C2  H1FOO2  H1FX2  HIST1H1A2  
    7 SIMAP similar genes for HIST1H1D using alignment to 1 protein entry:     H13_HUMAN:
    HIST1H1E    HIST1H1C    HIST1H1B    HIST1H1A    HIST1H1T    H1F0
    H1FX

    HIST1H1D for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H1D gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/133 NCBI SNPs in HIST1H1D are shown (see all 133)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1498540421,2
    		--26233945(+) AAAGGC/TCTGCG 1 -- ds50010--------
    rs1504184241,2
    		C--26233999(+) GACCA-/GCTGCTGC 1 -- ds50010--------
    rs1179310501,2
    		F--26234040(+) ATGCCA/GCGTAC 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs1141179431,2
    		F--26234042(+) GCCACG/TTACTG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1137997421,2
    		--26234121(+) ACATCC/TCTGTG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs168914561,2
    		C,F--26234127(+) CTGTGT/CCAGAA 1 -- ds50018Minor allele frequency- C:0.13NA CSA WA EA 504
    rs1918729061,2
    		--26234166(+) CGCCGC/TGCTTT 1 -- ds50010--------
    rs1490061721,2
    		--26234235(+) CTGGTA/GGCTCA 1 -- ds50010--------
    rs1437787461,2
    		--26234294(+) TCCTTA/GCGCCC 1 -- ds50010--------
    rs1835948611,2
    		--26234305(+) AGGCTG/TCTGGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HIST1H1D (26234440 - 26235216 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H1D: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for HIST1H1D gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H1D for disorders           About GeneDecksing

    OMIM gene information: 142210    OMIM disorders: --

    6 diseases for HIST1H1D:    About MalaCards
    treacher collins syndrome    paratyphoid fever    typhoid fever    pediatric crohns disease
    crohn's disease    meningioma

    2 diseases from the University of Copenhagen DISEASES database for HIST1H1D:
    Typhoid fever     Paratyphoid fever
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1D (5 documents)

    Export disorders for HIST1H1D gene to outside databases

    Publications
    for HIST1H1D gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H1D gene, integrated from 9 sources (see all 50):
    (articles sorted by number of sources associating them with HIST1H1D)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. (PubMed id 1916825)1, 2, 3 Albig W....Doenecke D. (1991)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. Distribution of somatic H1 subtypes is non-random on a ctive vs. inactive chromatin II: distribution in human adult fibroblasts. (PubMed id 11746507)1, 2 Parseghian M.H....Hamkalo B.A. (2001)
    7. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PubMed id 10997781)1, 2 Parseghian M.H....Hamkalo B.A. (2000)
    8. A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences. (PubMed id 8003976)1, 2 Parseghian M.H.... Hamkalo B.A. (1994)
    9. Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d. (PubMed id 2613692)1, 2 Ohe Y.... Iwai K. (1989)
    10. Nuclear envelope and chromatin compositional differences comparing undifferentiated and retinoic acid- and phorbol ester-treated HL-60 cells. (PubMed id 11478838)1, 9 Olins A.L....Olins D.E. (2001)

    External Searches for HIST1H1D gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing HIST1H1D gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3007 HGNC: 4717 AceView: HIST1H1D Ensembl:ENSG00000124575 euGenes: HUgn3007
    ECgene: HIST1H1D H-InvDB: HIST1H1D

    Other Databases showing HIST1H1D gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H1D gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H1D Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H1D gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H1D gene:
    Search GeneIP for patents involving HIST1H1D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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