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Aliases for HIST1H1C Gene

Aliases for HIST1H1C Gene

  • Histone Cluster 1, H1c 2 3
  • H1F2 3 4 6
  • H1 Histone Family, Member 2 2 3
  • Histone 1, H1c 2 3
  • Histone H1s-1 3 4
  • Histone H1c 3 4
  • Histone H1d 3 4
  • Histone H1.2 3
  • H1s-1 3
  • H1.2 3
  • H1C 3

External Ids for HIST1H1C Gene

Previous HGNC Symbols for HIST1H1C Gene

  • H1F2

Previous GeneCards Identifiers for HIST1H1C Gene

  • GC06M026113
  • GC06M026163
  • GC06M025998

Summaries for HIST1H1C Gene

Entrez Gene Summary for HIST1H1C Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H1C Gene

HIST1H1C (Histone Cluster 1, H1c) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Cellular Senescence. An important paralog of this gene is HIST1H1D.

UniProtKB/Swiss-Prot for HIST1H1C Gene

  • Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Wiki entry for HIST1H1C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1C Gene

Genomics for HIST1H1C Gene

Regulatory Elements for HIST1H1C Gene

Transcription factor binding sites by QIAGEN in the HIST1H1C gene promoter:

Genomic Location for HIST1H1C Gene

Start:
26,055,740 bp from pter
End:
26,056,471 bp from pter
Size:
732 bases
Orientation:
Minus strand

Genomic View for HIST1H1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1C Gene

Proteins for HIST1H1C Gene

  • Protein details for HIST1H1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16403-H12_HUMAN
    Recommended name:
    Histone H1.2
    Protein Accession:
    P16403
    Secondary Accessions:
    • A8K4I2

    Protein attributes for HIST1H1C Gene

    Size:
    213 amino acids
    Molecular mass:
    21365 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HIST1H1C Gene

Proteomics data for HIST1H1C Gene at MOPED

Post-translational modifications for HIST1H1C Gene

  • Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
  • Ubiquitination at Lys17, Lys34, Lys46, Lys63, Lys64, Lys75, Lys85, Lys90, Lys97, Lys106, and Lys206
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H1C Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST1H1C Gene

Domains for HIST1H1C Gene

Gene Families for HIST1H1C Gene

HGNC:
  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H1C Gene

Suggested Antigen Peptide Sequences for HIST1H1C Gene

Graphical View of Domain Structure for InterPro Entry

P16403

UniProtKB/Swiss-Prot:

H12_HUMAN :
  • P16403
Domain:
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1C: view

Function for HIST1H1C Gene

Molecular function for HIST1H1C Gene

UniProtKB/Swiss-Prot Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Ontology (GO) - Molecular Function for HIST1H1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 22720776
GO:0031490 chromatin DNA binding IDA 15911621
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HIST1H1C: view
genes like me logo Genes that share phenotypes with HIST1H1C: view

Animal Models for HIST1H1C Gene

MGI Knock Outs for HIST1H1C:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H1C

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HIST1H1C Gene

Localization for HIST1H1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1C Gene

Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H1C Gene COMPARTMENTS Subcellular localization image for HIST1H1C gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HIST1H1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IDA 22720776
GO:0005719 nuclear euchromatin IDA 15911621
genes like me logo Genes that share ontologies with HIST1H1C: view

Pathways for HIST1H1C Gene

genes like me logo Genes that share pathways with HIST1H1C: view

Pathways by source for HIST1H1C Gene

Gene Ontology (GO) - Biological Process for HIST1H1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0016584 nucleosome positioning IEA --
genes like me logo Genes that share ontologies with HIST1H1C: view

Compounds for HIST1H1C Gene

(1) Novoseek inferred chemical compound relationships for HIST1H1C Gene

Compound -log(P) Hits PubMed IDs
tyrosine 1.34 1
genes like me logo Genes that share compounds with HIST1H1C: view

Transcripts for HIST1H1C Gene

mRNA/cDNA for HIST1H1C Gene

(216) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1C Gene

Histone cluster 1, H1c:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H1C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1C Gene

No ASD Table

Relevant External Links for HIST1H1C Gene

GeneLoc Exon Structure for
HIST1H1C
ECgene alternative splicing isoforms for
HIST1H1C

Expression for HIST1H1C Gene

mRNA expression in normal human tissues for HIST1H1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1C Gene

This gene is overexpressed in Whole Blood (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H1C Gene

SOURCE GeneReport for Unigene cluster for HIST1H1C Gene Hs.7644

genes like me logo Genes that share expressions with HIST1H1C: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H1C Gene

Orthologs for HIST1H1C Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H1C 35
  • 98.9 (n)
  • 99.53 (a)
HIST1H1C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIST1H1C 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIST1H1C 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist1h1c 35
  • 82.08 (n)
  • 90.17 (a)
Hist1h1c 16
Hist1h1c 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 62 (a)
ManyToMany
HIST1H111L 36
  • 69 (a)
ManyToMany
HIST1H111R 36
  • 68 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01086354.1 36
  • 69 (a)
ManyToMany
CU457819.3 36
  • 72 (a)
ManyToMany
FP325123.1 36
  • 69 (a)
ManyToMany
histh1l 36
  • 65 (a)
ManyToMany
si:ch211-103n10.5 36
  • 55 (a)
ManyToMany
si:ch211-113a14.12 36
  • 65 (a)
ManyToMany
si:ch211-113a14.18 36
  • 64 (a)
ManyToMany
si:ch211-113a14.24 36
  • 64 (a)
ManyToMany
si:dkey-108k21.10 36
  • 64 (a)
ManyToMany
si:dkey-108k21.14 36
  • 63 (a)
ManyToMany
si:dkey-108k21.21 36
  • 59 (a)
ManyToMany
si:dkey-261m9.12 36
  • 63 (a)
ManyToMany
zgc:110425 36
  • 66 (a)
ManyToMany
zgc:153405 36
  • 65 (a)
ManyToMany
zgc:163061 36
  • 68 (a)
ManyToMany
zgc:163061 36
  • 68 (a)
ManyToMany
Species with no ortholog for HIST1H1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1C Gene

ENSEMBL:
Gene Tree for HIST1H1C (if available)
TreeFam:
Gene Tree for HIST1H1C (if available)

Paralogs for HIST1H1C Gene

Paralogs for HIST1H1C Gene

Selected SIMAP similar genes for HIST1H1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H1C: view

Variants for HIST1H1C Gene

Sequence variations from dbSNP and Humsavar for HIST1H1C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs8384 -- 26,055,844(-) AAGCC(C/G)AAGGC reference, synonymous-codon
rs10425 -- 26,056,321(-) GCGTC(C/T)GGTCC synonymous-codon, reference
rs1044070 -- 26,055,967(-) AAAAC(A/C)CCGAA reference, synonymous-codon
rs2230653 - 26,056,376(-) GAAGG(C/T)CCCTG reference, missense
rs7741511 -- 26,055,582(+) AATAA(A/G)GGTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1C Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914
nsv509122 CNV Insertion 20534489

Relevant External Links for HIST1H1C Gene

HapMap Linkage Disequilibrium report
HIST1H1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1C Gene

Disorders for HIST1H1C Gene

(1) University of Copenhagen DISEASES for HIST1H1C Gene

Relevant External Links for HIST1H1C

Genetic Association Database (GAD)
HIST1H1C
Human Genome Epidemiology (HuGE) Navigator
HIST1H1C
genes like me logo Genes that share disorders with HIST1H1C: view

No data available for UniProtKB/Swiss-Prot for HIST1H1C Gene

Publications for HIST1H1C Gene

  1. Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PMID: 2759094) Eick S. … Doenecke D. (Eur. J. Cell Biol. 1989) 2 3 4
  2. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  3. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PMID: 10997781) Parseghian M.H. … Hamkalo B.A. (Chromosome Res. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain. (PMID: 15911621) Th'ng J.P. … Hendzel M.J. (J. Biol. Chem. 2005) 3 4

Products for HIST1H1C Gene

Sources for HIST1H1C Gene

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