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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H1C Gene

protein-coding   GIFtS: 59
GCID: GC06M026055

histone cluster 1, H1c

(Previous names: H1 histone family, member 2, histone 1, H1c )
(Previous symbol: H1F2)
 Explore 4 diseases affiliated with
HIST1H1C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIST1H1C    

Aliases
for HIST1H1C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Histone Cluster 1, H1c1 2     Histone H1c2 3
H1F21 2 3 5     Histone H1d2 3
H1.21 2     Histone H1s-12 3
H1s-11 2     H1c1
H1 Histone Family, Member 21 2     H1C2
Histone 1, H1c1 2     Histone H1.22

External Ids:    HGNC: 47161   Entrez Gene: 30062   Ensembl: ENSG000001878377   OMIM: 1427105   UniProtKB: P164033   

Export aliases for HIST1H1C gene to outside databases

Previous GC identifers: GC06M026113 GC06M026163 GC06M025998


Summaries
for HIST1H1C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HIST1H1C:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two
molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp
of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between
nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and
encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a
palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H12_HUMAN, P16403
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the
chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured
fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and
DNA methylation (By similarity)

Gene Wiki entry for HIST1H1C


Genomic Views
for HIST1H1C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H1C gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H1C promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H1C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p21.3

HIST1H1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1C gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026055:  view genomic region     (about GC identifiers)

Start:
 26,055,915 bp from pter      End:
 26,056,699 bp from pter
Size:
 785 bases      Orientation:
 minus strand

Proteins
for HIST1H1C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: H12_HUMAN, P16403 (See protein sequence)
Recommended Name: Histone H1.2  
Size: 213 amino acids; 21365 Da
Subcellular location: Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA
concentration
Secondary accessions: A8K4I2

Explore the universe of human proteins at neXtProt for HIST1H1C: NX_P16403

Post-translational modifications:

  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2
    • phase and M phase, and being dephosphorylated sharply thereafter (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells,
    • including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active
    promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16403

    • HIST1H1C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005310.1  
    ENSEMBL proteins: 
     ENSP00000339566  
    Reactome Protein details: P16403
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for HIST1H1C
    OriGene Purified Protein: HIST1H1C
    OriGene Protein Over-expression Lysate: HIST1H1C
    OriGene Custom Protein Services for HIST1H1C 
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    Novus Biologicals HIST1H1C Protein
    Novus Biologicals HIST1H1C Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIST1H1C

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0005634nucleus IEA--


    HIST1H1C for ontologies           About GeneDecksing



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    Uscn Antibodies for HIST1H1C
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    Assay Products for HIST1H1C: 
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    Uscn ELISAs and CLIAs for HIST1H1C

    Protein Domains /
    Families
    for HIST1H1C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIST1H1C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR005819 Histone_H5
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR005818 Histone_H1/H5

    Graphical View of Domain Structure for InterPro Entry P16403

    ProtoNet protein and cluster: P16403

    1 Blocks protein family: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H12_HUMAN, P16403
    Domain: The C-terminal domain is required for high-affinity binding to chromatin (By similarity)
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    Function
    for HIST1H1C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: H12_HUMAN, P16403
    Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the
    chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured
    fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and
    DNA methylation (By similarity)

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H1C
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H1C:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: HIST1H1C
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H1C

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    Search LifeMap BioReagents cell lines for HIST1H1C

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
    GO:0005515protein binding ----


    HIST1H1C for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HIST1H1C:
     Increased HPV18 LCR reporter a 

    Animal Models:
         Mouse knock-outs for HIST1H1C: Hist1h1ctm1Ais Hist1h1ctm2Ais
         11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hist1h1c):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     immune system  limbs/digits/tail  mortality/aging  nervous system  normal 
     reproductive system 

    HIST1H1C for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HIST1H1C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of DNA fragmentation factor
    		Activation of DNA fragmentation factor1.00
    		Granzyme-A Pathway0.32
    		Apoptosis induced DNA fragmentation1.00
    2Cell cycle_Start of DNA replication in early S phase
    		Cell cycle_Start of DNA replication in early S phase1.00
    		Cell cycle Start of DNA replication in early S phase0.98
    3Cell cycle Chromosome condensation in prometaphase
    		Cell cycle Chromosome condensation in prometaphase1.00
    		Cell cycle_Chromosome condensation in prometaphase1.00
    4Apoptotic cleavage of cellular proteins
    		Apoptotic execution phase0.73
    5Activation of cAMP-Dependent PKA
    		PKA Signaling0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for HIST1H1C
        Histone modification
    Cell cycle Start of DNA replication in early S phase
    Cell cycle Chromosome condensation in prometaphase

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H1C
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1C
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase

    4        Reactome Pathways for HIST1H1C
        Activation of DNA fragmentation factor
    Apoptosis induced DNA fragmentation
    Apoptotic execution phase
    Apoptosis



    HIST1H1C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIST1H1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/196 Interacting proteins for HIST1H1C (P164032, 3 ENSP000003395664) via UniProtKB, MINT, STRING, and/or I2D (see all 196)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TONSLQ96HA72, ENSP000003862394MINT-8089673 MINT-8089790 STRING: ENSP00000386239
    NPM1P067482, 3, ENSP000002969304MINT-7899812 I2D: score=1 STRING: ENSP00000296930
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=2 STRING: ENSP00000238081
    EEDO755303, ENSP000002633604I2D: score=1 STRING: ENSP00000263360
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--
    GO:0016584nucleosome positioning ----


    HIST1H1C for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIST1H1C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIST1H1C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H1C
    1 Novoseek chemical compound relationship for HIST1H1C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 1.34 1 12719531 (1)

    Search CenterWatch for drugs/clinical trials and news about HIST1H1C / H12 

    Transcripts
    for HIST1H1C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIST1H1C gene: 
    NM_005319.3  

    Unigene Cluster for HIST1H1C:

    Histone cluster 1, H1c
    Hs.7644  [show with all ESTs]
    Unigene Representative Sequence: BQ940876
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343677(uc003nfw.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H1C
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H1C:
    hsa-miR-146a* hsa-miR-1276
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H1C (see all 4)
    OriGene shRNA RFP: HIST1H1C
    OriGene siRNA: HIST1H1C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H1C
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1C (see all 2)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H1C

    Additional cDNA sequence: 

    AB451259.1 AB451385.1 AK290947.1 

    7 DOTS entries:

    DT.446599  DT.100780817  DT.100780807  DT.100027030  DT.100780811  DT.121312631  DT.97776042 

    24/216 AceView cDNA sequences (see all 216):

    AI219278 AI126233 BX092939 BM821630 BF437691 CK821775 CA434015 AI683383 
    NM_005319 AI077654 BC002649 CR614667 R07384 AI149743 AI056489 AI148437 
    BE796184 BQ935952 BU184494 CD243663 BQ882224 AI675837 BP431973 BM830990 

    GeneLoc Exon Structure


    Expression
    for HIST1H1C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCCGAGACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIST1H1C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Mesendoderm-like cells (Generation of mesend...)

    See HIST1H1C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H1C

    SOURCE GeneReport for Unigene cluster: Hs.7644
        SABiosciences Custom PCR Arrays for HIST1H1C
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H1C
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    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1C

    Orthologs
    for HIST1H1C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H1C gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves F1NPJ2_CHICK6
    H101_CHICK6
    (see all 5)    		 Histone H1.01
    (see all 5)    		 67(a)
    67(a)
    (see all 5)    		 many ↔ many
    many ↔ many
    (see all 5)    		 1(49946004-49946660)
    1(50026207-50026866)
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    (see all 4)    		 --
    		 88(a)
    59(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 GL343400.1(426161-426382)
    GL343279.1(541498-542142)
    zebrafish
    (Danio rerio)    		 Actinopterygii CU457819.36
    CR354435.46
    (see all 15)    		 --
    		 69(a)
    69(a)
    (see all 15)    		 many ↔ many
    many ↔ many
    (see all 15)    		 7(7179641-7180171)
    25(37376502-37377026)
    fruit fly
    (Drosophila melanogaster)    		 Insecta His1:CG316176
    His1:CG338346
    (see all 23)    		 His1:CG33834
    (see all 23)    		 28(a)
    28(a)
    (see all 23)    		 many ↔ many
    many ↔ many
    (see all 23)    		 2L(21421980-21422877)
    2L(21486621-21487518)
    worm
    (Caenorhabditis elegans)    		 Secernentea hil-16
    		 Histone H1.X
    		 16(a)
    		 possible ortholog
    		 V(14949760-14952775)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons HIS1-36
    AT1G067606
    (see all 3)    		 histone H1.1
    (see all 3)    		 20(a)
    16(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 2(7845923-7846884)
    1(2076504-2077698)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 histone H1, putative, expressed
    (see all 4)    		 23(a)
    18(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 4(9984198-9985211)
    6(1641215-1642801)


    ENSEMBL Gene Tree for HIST1H1C (if available)
    TreeFam Gene Tree for HIST1H1C (if available) 

    Paralogs
    for HIST1H1C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H1C gene
    HIST1H1T2  HIST1H1E2  HIST1H1D2  H1F02  HIST1H1B2  H1FOO2  H1FX2  HIST1H1A2  
    7 SIMAP similar genes for HIST1H1C using alignment to 1 protein entry:     H12_HUMAN:
    HIST1H1E    HIST1H1B    HIST1H1D    HIST1H1A    HIST1H1T    H1F0
    H1FX

    HIST1H1C for paralogs           About GeneDecksing



    Genomic Variants
    for HIST1H1C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/164 NCBI SNPs in HIST1H1C are shown (see all 164)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1839031601,2
    		--26055520(+) GAAAAA/GAGGCA 1 -- ds50010--------
    rs1483173321,2
    		--26055547(+) GTAAAA/GCAAAA 1 -- ds50010--------
    rs1899374671,2
    		--26055570(+) GCAACA/GTCTTC 1 -- ds50010--------
    rs1921927531,2
    		--26055663(+) TTTTAC/GTCCAA 1 -- ds50010--------
    rs1414205071,2
    		--26055679(+) ACATCC/TCTTTA 1 -- ds50010--------
    rs1508356701,2
    		--26055705(+) TCTTGC/TTTTGC 1 -- ds50010--------
    rs779900151,2
    		F,--26055761(+) AAACCA/CTCCGC 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs77416321,2
    		C,F,H,--26055794(+) GGGACC/GTAGAA 1 -- ds50016Minor allele frequency- G:0.03NS EA WA 540
    rs77415111,2
    		C,--26055810(+) AATAAA/GGGTTT 1 -- ds50010--------
    rs789061701,2
    		C,--26055863(+) ATTCG-/TCTCTGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HIST1H1C (26055915 - 26056699 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIST1H1C: --

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    Disorders / Diseases
    for HIST1H1C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIST1H1C for disorders           About GeneDecksing

    OMIM gene information: 142710    OMIM disorders: --

    4 diseases for HIST1H1C:    About MalaCards
    chronic lymphocytic leukemia    lymphocytic leukemia    parkinson's disease    leukemia

    1 disease from the University of Copenhagen DISEASES database for HIST1H1C:
    Progressive supranuclear palsy
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1C (4 documents)

    Export disorders for HIST1H1C gene to outside databases

    Publications
    for HIST1H1C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H1C gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with HIST1H1C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    2. Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PubMed id 2759094)1, 2, 3 Eick S.... Doenecke D. (1989)
    3. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PubMed id 10997781)1, 2 Parseghian M.H....Hamkalo B.A. (2000)
    7. A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences. (PubMed id 8003976)1, 2 Parseghian M.H.... Hamkalo B.A. (1994)
    8. Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d. (PubMed id 2613692)1, 2 Ohe Y.... Iwai K. (1989)
    9. Histone H1.2 is translocated to mitochondria and associates with Bak in bleomycin-induced apoptotic cells. (PubMed id 17879944)1, 9 Okamura H....Haneji T. (2008)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    External Searches for HIST1H1C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIST1H1C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3006 HGNC: 4716 AceView: HIST1H1C Ensembl:ENSG00000187837 euGenes: HUgn3006
    ECgene: HIST1H1C H-InvDB: HIST1H1C

    Other Databases showing HIST1H1C gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIST1H1C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H1C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIST1H1C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIST1H1C gene:
    Search GeneIP for patents involving HIST1H1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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