Aliases for HIST1H1C Gene
Aliases for HIST1H1C Gene
External Ids for HIST1H1C Gene
- HGNC: 4716
- Entrez Gene: 3006
- Ensembl: ENSG00000187837
- OMIM: 142710
- UniProtKB: P16403
Previous HGNC Symbols for HIST1H1C Gene
- H1F2
Previous GeneCards Identifiers for HIST1H1C Gene
- GC06M026113
- GC06M026163
- GC06M025998
Summaries for HIST1H1C Gene
-
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H1C Gene
HIST1H1C (Histone Cluster 1 H1 Family Member C) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Apoptosis induced DNA fragmentation. GO annotations related to this gene include poly(A) RNA binding and chromatin DNA binding. An important paralog of this gene is HIST1H1E.
UniProtKB/Swiss-Prot for HIST1H1C Gene
-
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1C Gene
Genomics for HIST1H1C Gene
Regulatory Elements for HIST1H1C Gene
- Transcription factor binding sites by QIAGEN in the HIST1H1C gene promoter:
Regulatory Element Products
Genomic Location for HIST1H1C Gene
- Chromosome:
- 6
- Start:
- 26,055,740 bp from pter
- End:
- 26,056,471 bp from pter
- Size:
- 732 bases
- Orientation:
- Minus strand
Genomic View for HIST1H1C Gene
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H1C Gene
Proteins for HIST1H1C Gene
-
Protein details for HIST1H1C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P16403-H12_HUMAN
- Recommended name:
- Histone H1.2
- Protein Accession:
- P16403
- A8K4I2
Protein attributes for HIST1H1C Gene
- Size:
- 213 amino acids
- Molecular mass:
- 21365 Da
- Quaternary structure:
- No Data Available
Protein Expression for HIST1H1C Gene
Post-translational modifications for HIST1H1C Gene
- ADP-ribosylated on Ser-188 in response to DNA damage.
- Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
- Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
- H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
- Ubiquitination at isoforms=206
- Modification sites at PhosphoSitePlus
Other Protein References for HIST1H1C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIST1H1C
-
Custom Antibody ServicesOriGene Antibodies for HIST1H1C
- Novus Biologicals Antibodies for HIST1H1C
-
Abcam antibodies for HIST1H1C
- Invitrogen Antibodies for HIST1H1C
- antibodies-online Antibodies for HIST1H1C: See all 38
- GeneTex HIST1H1C antibody for HIST1H1C
Protein Products
-
OriGene Purified Proteins for HIST1H1C
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- antibodies-online Proteins for HIST1H1C: See all 5
- Search antibodies-online for peptides
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-
Abcam proteins for HIST1H1C
Assay Products
- antibodies-online Kits for HIST1H1C: See all 1
No data available for DME Specific Peptides for HIST1H1C Gene
Domains & Families for HIST1H1C Gene
Gene Families for HIST1H1C Gene
- HGNC:
Protein Domains for HIST1H1C Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H1C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P16403UniProtKB/Swiss-Prot:
H12_HUMAN :- The C-terminal domain is required for high-affinity binding to chromatin.
- Belongs to the histone H1/H5 family.
- Domain:
-
- The C-terminal domain is required for high-affinity binding to chromatin.
- Family:
-
- Belongs to the histone H1/H5 family.
Function for HIST1H1C Gene
Molecular function for HIST1H1C Gene
- UniProtKB/Swiss-Prot Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0005515 | protein binding | IPI | 21383955 |
| GO:0031490 | chromatin DNA binding | IDA | 15911621 |
Phenotypes for HIST1H1C Gene
- MGI mutant phenotypes for HIST1H1C:
-
inferred from 2 alleles
- mortality/aging
- cellular phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- nervous system phenotype
- cardiovascular system phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- limbs/digits/tail phenotype
- embryo phenotype
- hematopoietic system phenotype
- GenomeRNAi human phenotypes for HIST1H1C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H1C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1C gene
- Search ViGene Biosciences for HIST1H1C
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H1C
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H1C
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miRNA for HIST1H1C Gene
- miRTarBase miRNAs that target HIST1H1C
-
- hsa-mir-34a-5p (MIRT025536)
- hsa-mir-98-5p (MIRT027797)
- hsa-mir-423-5p (MIRT038090)
- hsa-mir-652-3p (MIRT039500)
- hsa-mir-18a-3p (MIRT040862)
- hsa-mir-324-3p (MIRT042928)
- hsa-mir-99b-5p (MIRT044173)
- hsa-mir-186-5p (MIRT045075)
- hsa-mir-27b-3p (MIRT046184)
- hsa-mir-16-5p (MIRT051144)
- hsa-let-7b-5p (MIRT051896)
- hsa-mir-760 (MIRT100036)
- hsa-mir-6822-3p (MIRT100042)
- hsa-mir-6839-3p (MIRT504381)
- hsa-mir-4507 (MIRT504382)
- hsa-mir-3940-5p (MIRT504383)
- hsa-mir-629-5p (MIRT504384)
- hsa-mir-5693 (MIRT511800)
- hsa-mir-8057 (MIRT511801)
- hsa-mir-4766-5p (MIRT511802)
- hsa-mir-146a-3p (MIRT511803)
- hsa-mir-1276 (MIRT511804)
miRNA Products
- Search ViGene Biosciences for HIST1H1C
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H1C
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-
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HIST1H1C
-
ViGene Biosciences adenoviral particle packaged cDNA for HIST1H1C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIST1H1C gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIST1H1C Gene
Localization for HIST1H1C Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1C Gene
- Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0005634 | nucleus | IDA | 21383955 |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005719 | nuclear euchromatin | IDA | 15911621 |
| GO:0035327 | transcriptionally active chromatin | IEA | -- |
Pathways & Interactions for HIST1H1C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis induced DNA fragmentation | ||
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
| 3 | Cellular Senescence | ||
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | Activation of cAMP-Dependent PKA |
.56
|
|
Pathways by source for HIST1H1C Gene
1 GeneTex pathway for HIST1H1C Gene
9 Reactome pathways for HIST1H1C Gene
2 GeneGo (Thomson Reuters) pathways for HIST1H1C Gene
2 Qiagen pathways for HIST1H1C Gene
Interacting Proteins for HIST1H1C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006334 | nucleosome assembly | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0016584 | nucleosome positioning | IEA | -- |
| GO:0080182 | histone H3-K4 trimethylation | IEA | -- |
No data available for SIGNOR curated interactions for HIST1H1C Gene
Transcripts for HIST1H1C Gene
mRNA/cDNA for HIST1H1C Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (216) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H1C Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIST1H1C
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIST1H1C
- GenScript: Design CRISPR guide RNA sequences for HIST1H1C
miRNA Products
- Search ViGene Biosciences for HIST1H1C
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIST1H1C
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-
ViGene Biosciences ready-to-package AAV shRNAs for HIST1H1C gene
Clone Products
-
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Flow Cytometry Products
Expression for HIST1H1C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Double Positive Thymocytes Thymus
-
Eye (Sensory Organs)
- Mature Rod Cells Outer Nuclear Layer
-
Neurons
- Mature Rod Cells Outer Nuclear Layer
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
mRNA differential expression in normal tissues according to GTEx for HIST1H1C Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H1C Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H1C Gene:
HIST1H1CSOURCE GeneReport for Unigene cluster for HIST1H1C Gene:
Hs.7644Evidence on tissue expression from TISSUES for HIST1H1C Gene
- Spleen(4.3)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HIST1H1C
-
OriGene qPCR primer pairs for HIST1H1C
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H1C Gene
Orthologs for HIST1H1C Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIST1H1C 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HIST1H1C 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HIST1H1C 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hist1h1c 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | HIST1H111L 35 |
|
ManyToMany | |
| HIST1H111R 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | CU457819.3 35 |
|
ManyToMany | |
| CABZ01086354.1 35 |
|
ManyToMany | |||
| FP325123.1 35 |
|
ManyToMany | |||
| zgc:163061 35 35 |
|
ManyToMany | |||
| zgc:110425 35 |
|
ManyToMany | |||
| histh1l 35 |
|
ManyToMany | |||
| si:ch211-113a14.12 35 |
|
ManyToMany | |||
| zgc:153405 35 |
|
ManyToMany | |||
| si:ch211-113a14.18 35 |
|
ManyToMany | |||
| si:ch211-113a14.24 35 |
|
ManyToMany | |||
| si:dkey-108k21.10 35 |
|
ManyToMany | |||
| si:dkey-108k21.14 35 |
|
ManyToMany | |||
| si:dkey-261m9.12 35 |
|
ManyToMany | |||
| si:dkey-108k21.21 35 |
|
ManyToMany | |||
| si:ch211-103n10.5 35 |
|
ManyToMany |
- Species where no ortholog for HIST1H1C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST1H1C Gene
Variants for HIST1H1C Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000040165 | -- | 26,055,281(+) | TAATA(C/T)AAAGA | downstream-variant-500B | |
| rs1000409096 | -- | 26,055,466(+) | AAGAA(A/C)CTGGC | downstream-variant-500B | |
| rs1000903196 | -- | 26,056,428(+) | GGACA(C/T)GTTGA | reference, missense | |
| rs1000914731 | -- | 26,058,169(+) | AAGAA(C/T)TATAC | upstream-variant-2KB | |
| rs1001712340 | -- | 26,055,708(+) | TAGTA(-/AAG)AAATT | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv1026692 | CNV | loss | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv509122 | CNV | insertion | 20534489 |
Relevant External Links for HIST1H1C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H1C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1C Gene
Disorders for HIST1H1C Gene
Relevant External Links for HIST1H1C
No disorders were found for HIST1H1C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1C Gene
Publications for HIST1H1C Gene
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PMID: 2759094) Eick S. … Doenecke D. (Eur. J. Cell Biol. 1989) 2 3 4 64
- Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 64
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
- Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PMID: 18568448) Mizuta I. … Toda T. (Hum. Genet. 2008) 3 46 64
Products for HIST1H1C Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIST1H1C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
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