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HIST1H1C Gene

protein-coding   GIFtS: 64
GCID: GC06M026055

Histone Cluster 1, H1c

(Previous names: H1 histone family, member 2, histone 1, H1c)
(Previous symbol: H1F2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H1c1 2     Histone H1s-12 3
H1F21 2 3 5     H1.22
H1 Histone Family, Member 21 2     H1C2
Histone 1, H1c1 2     H1s-12
Histone H1c2 3     Histone H1.22
Histone H1d2 3     

External Ids:    HGNC: 47161   Entrez Gene: 30062   Ensembl: ENSG000001878377   OMIM: 1427105   UniProtKB: P164033   

Export aliases for HIST1H1C gene to outside databases

Previous GC identifers: GC06M026113 GC06M026163 GC06M025998


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H1C Gene:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes.
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H1C Gene:
HIST1H1C (histone cluster 1, H1c) is a protein-coding gene. Diseases associated with HIST1H1C include progressive supranuclear palsy, and burns. An important paralog of this gene is HIST1H1T.

UniProtKB/Swiss-Prot: H12_HUMAN, P16403
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
nucleosome spacing and DNA methylation (By similarity)

Gene Wiki entry for HIST1H1C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H1C gene promoter:
         C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H1C promoter sequence
   Search Chromatin IP Primers for HIST1H1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p21.3

HIST1H1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1C gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026055:  view genomic region     (about GC identifiers)

Start:
26,055,968 bp from pter      End:
26,056,699 bp from pter
Size:
732 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: H12_HUMAN, P16403 (See protein sequence)
Recommended Name: Histone H1.2  
Size: 213 amino acids; 21365 Da
Secondary accessions: A8K4I2

Explore the universe of human proteins at neXtProt for HIST1H1C: NX_P16403

Explore proteomics data for HIST1H1C at MOPED

Post-translational modifications: 

  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late
    G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity)1
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic
    cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks
    active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with
    post-meiotically activated genes on autosomes1
  • Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its
    displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell
    maintenance (By similarity)1
  • Ubiquitination2 at Lys17, Lys34, Lys46, Lys63, Lys64, Lys75, Lys85, Lys90, Lys97, Lys106,
                                 Lys206
  • Modification sites at PhosphoSitePlus

  • See HIST1H1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005310.1  
    ENSEMBL proteins: 
     ENSP00000339566  
    Reactome Protein details: P16403

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR005819 Histone_H5
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5_H15

    Graphical View of Domain Structure for InterPro Entry P16403

    ProtoNet protein and cluster: P16403

    1 Blocks protein domain: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H12_HUMAN, P16403
    Domain: The C-terminal domain is required for high-affinity binding to chromatin (By similarity)
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    HIST1H1C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H12_HUMAN, P16403
    Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
    the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
    structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
    nucleosome spacing and DNA methylation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
    GO:0044822poly(A) RNA binding IDA--
         
    HIST1H1C for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HIST1H1C:
     Increased HPV18 LCR reporter a 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hist1h1c):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     immune system  limbs/digits/tail  mortality/aging  nervous system  normal 
     reproductive system 

    HIST1H1C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HIST1H1C: Hist1h1ctm1Ais Hist1h1ctm2Ais

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H1C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIST1H1C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H1C

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIST1H1C:
    hsa-mir-99b-5p (MIRT044173), hsa-mir-652-3p (MIRT039500), hsa-mir-18a-3p (MIRT040862), hsa-mir-324-3p (MIRT042928), hsa-mir-16-5p (MIRT051144), hsa-mir-98-5p (MIRT027797), hsa-let-7b-5p (MIRT051896), hsa-mir-186-5p (MIRT045075), hsa-mir-423-5p (MIRT038090), hsa-mir-27b-3p (MIRT046184), hsa-mir-34a-5p (MIRT025536)

    Block miRNA regulation of human, mouse, rat HIST1H1C using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate HIST1H1C:
    hsa-miR-146a* hsa-miR-1276
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H12_HUMAN, P16403: Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel
    with DNA concentration
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0005634nucleus IEA--

    HIST1H1C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H1C About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor0.32
    Apoptosis induced DNA fragmentation0.00
    Granzyme-A Pathway0.32
    2Packaging Of Telomere Ends
    DNA Damage/Telomere Stress Induced Senescence0.65
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)0.00
    Histone modification0.31
    3Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    4Apoptotic cleavage of cellular proteins
    Apoptotic execution phase0.74
    5Activation of cAMP-Dependent PKA
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H1C
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1C
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase

    2 Reactome Pathways for HIST1H1C
        Activation of DNA fragmentation factor
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)



    HIST1H1C for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H1C
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H1C (P164032, 3 ENSP000003395664) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TONSLQ96HA72, ENSP000003862394MINT-8089673 MINT-8089790 STRING: ENSP00000386239
    NPM1P067482, 3, ENSP000002969304MINT-7899812 I2D: score=1 STRING: ENSP00000296930
    YWHAQP273482, 3, ENSP000002380814MINT-7899812 I2D: score=2 STRING: ENSP00000238081
    EEDO755303, ENSP000002633604I2D: score=1 STRING: ENSP00000263360
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0016584nucleosome positioning IEA--

    HIST1H1C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H1C (H12)

    1 Novoseek inferred chemical compound relationship for HIST1H1C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 1.34 1 12719531 (1)



    HIST1H1C for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H1C gene: 
    NM_005319.3  

    Unigene Cluster for HIST1H1C:

    Histone cluster 1, H1c
    Hs.7644  [show with all ESTs]
    Unigene Representative Sequence: BQ940876
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000343677(uc003nfw.3)

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    Additional mRNA sequence: 

    AB451259.1 AB451385.1 AK290947.1 

    7 DOTS entries:

    DT.446599  DT.100780817  DT.100780807  DT.100027030  DT.100780811  DT.121312631  DT.97776042 

    Selected AceView cDNA sequences (see all 216):

    AI056489 AI126233 BF437691 CR614667 R07384 BC002649 CK821775 AI149743 
    AI219278 AI077654 CA434015 BM821630 AI683383 NM_005319 BX092939 CD243663 
    BM737917 AI923811 BU953725 AI609805 BM662666 BM312015 BQ720436 AI884963 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCGAGACTG
    HIST1H1C Expression
    About this image


    HIST1H1C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    HIST1H1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.7644
        Custom PCR Arrays for HIST1H1C
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H1C gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h1c1 , 5 histone cluster 1, H1c1, 5 82.08(n)1
    90.17(a)1
      13 (9.90 cM)5
    507081  NM_015786.21  NP_056601.11 
     237388085 
    chicken
    (Gallus gallus)
    Aves HIST1H111L6
    HIST1H111R6
    (see all 3)
    Gallus gallus histone cluster 1, H1.11L (similar t...
    Gallus gallus histone cluster 1, H1.11R (similar t...
    (see all 3)
    69(a)
    68(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(48025516-48026285)
    1(48033617-48034276)
    zebrafish
    (Danio rerio)
    Actinopterygii CU457819.36
    FP325123.16
    (see all 16)
    Uncharacterized protein
    (see all 16)
    72(a)
    69(a)
    (see all 16)
    many ↔ many
    many ↔ many
    (see all 16)
    7(7179641-7180171) ENSDARG00000090426
    7(7270975-7271457) ENSDARG00000074012


    ENSEMBL Gene Tree for HIST1H1C (if available)
    TreeFam Gene Tree for HIST1H1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H1C gene
    HIST1H1T2  HIST1H1E2  H1F02  HIST1H1D2  HIST1H1B2  HIST1H1A2  
    7 SIMAP similar genes for HIST1H1C using alignment to 1 protein entry:     H12_HUMAN:
    HIST1H1E    HIST1H1B    HIST1H1D    HIST1H1A    HIST1H1T    H1F0
    H1FX

    HIST1H1C for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H1C (see all 223)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839031601,2
    --26055520(+) GAAAAA/GAGGCA 1 -- ds50010--------
    rs1483173321,2
    C--26055547(+) GTAAAA/GCAAAA 1 -- ds50010--------
    rs1899374671,2
    --26055570(+) GCAACA/GTCTTC 1 -- ds50010--------
    rs1921927531,2
    C--26055663(+) TTTTAC/GTCCAA 1 -- ds50010--------
    rs1414205071,2
    --26055679(+) ACATCC/TCTTTA 1 -- ds50010--------
    rs1508356701,2
    C--26055705(+) TCTTGC/TTTTGC 1 -- ds50010--------
    rs779900151,2
    C,F--26055761(+) AAACCA/CTCCGC 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs77416321,2
    C,F,H--26055794(+) GGGACC/GTAGAA 1 -- ds50016Minor allele frequency- G:0.03NS EA WA 540
    rs77415111,2
    C,F--26055810(+) AATAAA/GGGTTT 1 -- ds50010--------
    rs789061701,2
    C--26055865(+) ATTCG-/TCTCTGA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HIST1H1C (26055968 - 26056699 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H1C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509122CNV Insertion20534489
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H1C
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142710    OMIM disorders: --

    8 diseases for HIST1H1C:    
    About MalaCards
    progressive supranuclear palsy    burns    hemochromatosis    childhood leukemia
    chronic lymphocytic leukemia    parkinson's disease    neuroblastoma    leukemia

    1 disease from the University of Copenhagen DISEASES database for HIST1H1C:
    Progressive supranuclear palsy

    HIST1H1C for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): HIST1H1C
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1C (4 documents)

    Export disorders for HIST1H1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H1C gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with HIST1H1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PubMed id 2759094)1, 2, 3 Eick S.... Doenecke D. (Eur. J. Cell Biol. 1989)
    3. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease. (PubMed id 18568448)1, 4 Mizuta I....Toda T. (Hum. Genet. 2008)
    6. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PubMed id 10997781)1, 2 Parseghian M.H.... Hamkalo B.A. (Chromosome Res. 2000)
    10. A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences. (PubMed id 8003976)1, 2 Parseghian M.H.... Hamkalo B.A. (Protein Sci. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3006 HGNC: 4716 AceView: HIST1H1C Ensembl:ENSG00000187837 euGenes: HUgn3006
    ECgene: HIST1H1C H-InvDB: HIST1H1C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H1C gene:
    Search GeneIP for patents involving HIST1H1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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