Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIST1H1C Gene

Aliases for HIST1H1C Gene

  • Histone Cluster 1 H1 Family Member C 2 3 5
  • H1 Histone Family, Member 2 2 3
  • Histone Cluster 1, H1c 2 3
  • Histone 1, H1c 2 3
  • Histone H1s-1 3 4
  • Histone H1c 3 4
  • Histone H1d 3 4
  • H1F2 3 4
  • Histone H1.2 3
  • H1s-1 3
  • H1.2 3
  • H1C 3

External Ids for HIST1H1C Gene

Previous HGNC Symbols for HIST1H1C Gene

  • H1F2

Previous GeneCards Identifiers for HIST1H1C Gene

  • GC06M026113
  • GC06M026163
  • GC06M025998

Summaries for HIST1H1C Gene

Entrez Gene Summary for HIST1H1C Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H1C Gene

HIST1H1C (Histone Cluster 1 H1 Family Member C) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Apoptosis induced DNA fragmentation. GO annotations related to this gene include poly(A) RNA binding and chromatin DNA binding. An important paralog of this gene is HIST1H1E.

UniProtKB/Swiss-Prot for HIST1H1C Gene

  • Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Wiki entry for HIST1H1C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1C Gene

Genomics for HIST1H1C Gene

Regulatory Elements for HIST1H1C Gene

Enhancers for HIST1H1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G026019 1.9 FANTOM5 ENCODE dbSUPER 21.1 +28.9 28885 16.2 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 ABT1 HMGN4 ENSG00000272462 BTN3A2 ZNF322 HIST1H1C BTN3A1 NUP50P2 HIST1H2APS5 BTN3A3
GH06G025991 1.9 FANTOM5 ENCODE dbSUPER 9.6 +63.9 63859 2.9 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 ENSG00000272462 ABT1 BTN3A2 ZNF322 HMGN4 HIST1H1C GC06P025976
GH06G026120 2.1 FANTOM5 Ensembl ENCODE dbSUPER 7 -67.5 -67504 7.8 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 SSRP1 ABT1 ENSG00000272462 HMGN4 NUP50P2 ZNF322 HFE BTN3A2 HIST1H1C HIST1H2APS5 BTN3A1
GH06G026042 1.3 ENCODE dbSUPER 9.7 +11.6 11642 4.7 HDGF PKNOX1 FOXA2 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YY1 ENSG00000272462 BTN3A2 ZNF322 HIST1H2APS5 HMGN4 HIST1H1C HFE TRIM38 GC06P026043 HIST1H3C
GH06G026086 1 ENCODE 11.8 -31.6 -31605 2.8 CREB3L1 AGO1 SIN3A DMAP1 YY1 SLC30A9 ZNF766 KLF13 SMARCB1 ZNF592 ENSG00000272462 HIST1H1C HIST1H1T LARP1P1 HIST1H2BE BTN3A2 HFE GC06P026096
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST1H1C on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H1C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000194977 771 3001 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3

Transcription factor binding sites by QIAGEN in the HIST1H1C gene promoter:

Genomic Location for HIST1H1C Gene

Chromosome:
6
Start:
26,055,740 bp from pter
End:
26,056,471 bp from pter
Size:
732 bases
Orientation:
Minus strand

Genomic View for HIST1H1C Gene

Genes around HIST1H1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1C Gene

Proteins for HIST1H1C Gene

  • Protein details for HIST1H1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16403-H12_HUMAN
    Recommended name:
    Histone H1.2
    Protein Accession:
    P16403
    Secondary Accessions:
    • A8K4I2

    Protein attributes for HIST1H1C Gene

    Size:
    213 amino acids
    Molecular mass:
    21365 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HIST1H1C Gene

Post-translational modifications for HIST1H1C Gene

  • ADP-ribosylated on Ser-188 in response to DNA damage.
  • Citrullination at Arg-54 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes.
  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
  • Ubiquitination at isoforms=206
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H1C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H1C Gene

Domains & Families for HIST1H1C Gene

Gene Families for HIST1H1C Gene

Protein Domains for HIST1H1C Gene

Suggested Antigen Peptide Sequences for HIST1H1C Gene

Graphical View of Domain Structure for InterPro Entry

P16403

UniProtKB/Swiss-Prot:

H12_HUMAN :
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Belongs to the histone H1/H5 family.
Domain:
  • The C-terminal domain is required for high-affinity binding to chromatin.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1C: view

Function for HIST1H1C Gene

Molecular function for HIST1H1C Gene

UniProtKB/Swiss-Prot Function:
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Ontology (GO) - Molecular Function for HIST1H1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 21383955
GO:0031490 chromatin DNA binding IDA 15911621
genes like me logo Genes that share ontologies with HIST1H1C: view
genes like me logo Genes that share phenotypes with HIST1H1C: view

Animal Models for HIST1H1C Gene

MGI Knock Outs for HIST1H1C:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIST1H1C Gene

Localization for HIST1H1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1C Gene

Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H1C gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HIST1H1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0005634 nucleus IDA 21383955
GO:0005694 chromosome IEA --
GO:0005719 nuclear euchromatin IDA 15911621
GO:0035327 transcriptionally active chromatin IEA --
genes like me logo Genes that share ontologies with HIST1H1C: view

Pathways & Interactions for HIST1H1C Gene

genes like me logo Genes that share pathways with HIST1H1C: view

Pathways by source for HIST1H1C Gene

Gene Ontology (GO) - Biological Process for HIST1H1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006334 nucleosome assembly IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0016584 nucleosome positioning IEA --
GO:0080182 histone H3-K4 trimethylation IEA --
genes like me logo Genes that share ontologies with HIST1H1C: view

No data available for SIGNOR curated interactions for HIST1H1C Gene

Drugs & Compounds for HIST1H1C Gene

(1) Drugs for HIST1H1C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HIST1H1C: view

Transcripts for HIST1H1C Gene

mRNA/cDNA for HIST1H1C Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(216) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1C Gene

Histone cluster 1, H1c:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1C Gene

No ASD Table

Relevant External Links for HIST1H1C Gene

GeneLoc Exon Structure for
HIST1H1C
ECgene alternative splicing isoforms for
HIST1H1C

Expression for HIST1H1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIST1H1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1C Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for HIST1H1C Gene

This gene is overexpressed in Tlymphocyte (26.4) and Neutrophil (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H1C Gene



NURSA nuclear receptor signaling pathways regulating expression of HIST1H1C Gene:

HIST1H1C

SOURCE GeneReport for Unigene cluster for HIST1H1C Gene:

Hs.7644

Evidence on tissue expression from TISSUES for HIST1H1C Gene

  • Spleen(4.3)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with HIST1H1C: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H1C Gene

Orthologs for HIST1H1C Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H1C 34 35
  • 98.9 (n)
cow
(Bos Taurus)
Mammalia HIST1H1C 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIST1H1C 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist1h1c 34 16 35
  • 82.08 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 80 (a)
ManyToMany
-- 35
  • 69 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
OneToMany
chicken
(Gallus gallus)
Aves HIST1H111L 35
  • 69 (a)
ManyToMany
HIST1H111R 35
  • 68 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU457819.3 35
  • 72 (a)
ManyToMany
CABZ01086354.1 35
  • 69 (a)
ManyToMany
FP325123.1 35
  • 69 (a)
ManyToMany
zgc:163061 35 35
  • 68 (a)
ManyToMany
zgc:110425 35
  • 66 (a)
ManyToMany
histh1l 35
  • 65 (a)
ManyToMany
si:ch211-113a14.12 35
  • 65 (a)
ManyToMany
zgc:153405 35
  • 65 (a)
ManyToMany
si:ch211-113a14.18 35
  • 64 (a)
ManyToMany
si:ch211-113a14.24 35
  • 64 (a)
ManyToMany
si:dkey-108k21.10 35
  • 64 (a)
ManyToMany
si:dkey-108k21.14 35
  • 63 (a)
ManyToMany
si:dkey-261m9.12 35
  • 63 (a)
ManyToMany
si:dkey-108k21.21 35
  • 59 (a)
ManyToMany
si:ch211-103n10.5 35
  • 55 (a)
ManyToMany
Species where no ortholog for HIST1H1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1C Gene

ENSEMBL:
Gene Tree for HIST1H1C (if available)
TreeFam:
Gene Tree for HIST1H1C (if available)

Paralogs for HIST1H1C Gene

Paralogs for HIST1H1C Gene

(7) SIMAP similar genes for HIST1H1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H1C: view

Variants for HIST1H1C Gene

Sequence variations from dbSNP and Humsavar for HIST1H1C Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000040165 -- 26,055,281(+) TAATA(C/T)AAAGA downstream-variant-500B
rs1000409096 -- 26,055,466(+) AAGAA(A/C)CTGGC downstream-variant-500B
rs1000903196 -- 26,056,428(+) GGACA(C/T)GTTGA reference, missense
rs1000914731 -- 26,058,169(+) AAGAA(C/T)TATAC upstream-variant-2KB
rs1001712340 -- 26,055,708(+) TAGTA(-/AAG)AAATT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1C Gene

Variant ID Type Subtype PubMed ID
dgv5926n100 CNV gain 25217958
nsv1023453 CNV gain 25217958
nsv1026692 CNV loss 25217958
nsv428137 CNV loss 18775914
nsv509122 CNV insertion 20534489

Variation tolerance for HIST1H1C Gene

Residual Variation Intolerance Score: 83.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1C Gene

Disorders for HIST1H1C Gene

Relevant External Links for HIST1H1C

Genetic Association Database (GAD)
HIST1H1C
Human Genome Epidemiology (HuGE) Navigator
HIST1H1C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H1C

No disorders were found for HIST1H1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1C Gene

Publications for HIST1H1C Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  2. Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PMID: 2759094) Eick S. … Doenecke D. (Eur. J. Cell Biol. 1989) 2 3 4 64
  3. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 64
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  5. Histone H1.2 is translocated to mitochondria and associates with Bak in bleomycin-induced apoptotic cells. (PMID: 17879944) Okamura H. … Haneji T. (J. Cell. Biochem. 2008) 3 22 64

Products for HIST1H1C Gene

Sources for HIST1H1C Gene

Content
Loading form....