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HIST1H1B Gene

protein-coding   GIFtS: 54

GC06M027942
histone cluster 1, H1b
(Previous names: H1 histone family, member 5, histone 1, H1b )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: H1F5)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
H1 2
H1.5 1, 2
H1F5 2, 3, 5
MGC126630 2
MGC126632 2
OTTHUMP00000017748 2
Descriptions
H1 histone family, member 5 1, 2
Histone H1a 3
histone 1, H1b 1, 2
histone cluster 1, H1b 2
External Ids
HGNC: 47191
Entrez Gene: 30092
UniProtKB: P164013
Ensembl: ENSG000001843577
Search outside databases for aliases for HIST1H1B gene

Previous GC identifer: GC06M027893

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for HIST1H1B:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber
in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an
octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called
nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions
in the compaction of chromatin into higher order structures. This gene is intronless and encodes a
member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a
palindromic termination element. This gene is found in the small histone gene cluster on
chromosome 6p22-p21.3. [provided by RefSeq]

UniProtKB/Swiss-Prot: H15_HUMAN, P16401
Function: Histones H1 are necessary for the condensation of nucleosome chains into higher order
structures

Gene Wiki entry for HIST1H1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HIST1H1B gene  

Entrez Gene cytogenetic band: 6p22-p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027942:     (about GC identifiers)

Start:
27,942,549 bp from pter
End:
27,943,404 bp from pter
Size:
856 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: H15_HUMAN, P16401 (See protein sequence)
Recommended Name: Histone H1.5  
Size: 226 amino acids; 22580 Da
Subcellular location: Nucleus
PDB structure from and Proteopedia :
2FE2 (3D)    2RHI (3D)    
Secondary accessions: Q14529 Q3MJ42

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005313.1  

    ENSEMBL proteins: 
    ENSP00000330074 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Histone H1.5, Histone H1, Histones)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786 nucleosome NAS--
    GO:0005634 nucleus IEA--
    GO:0005694 chromosome IEA--
    About this table

    Antibodies for HIST1H1B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Histone H1.5, Histone H1, Histones), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for HIST1H1B

    Assays for HIST1H1B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR005819 Histone_H5
     IPR011991 Wing_hlx_DNA_bd
     IPR005818 Histone_H1/H5


       GeneDecks  HIST1H1B for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P16401

    ProtoNet protein and cluster: P16401

    1 Blocks protein family: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H15_HUMAN, P16401
    Similarity: Belongs to the histone H1/H5 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (HIST1H1B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HIST1H1B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005322

                  Applied Biosystems Silencer® siRNAs for HIST1H1B

                  Sigma-Aldrich siRNA for HIST1H1B  
                         Sigma-Aldrich shRNA for HIST1H1B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005322
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005322
                                     untagged cDNA clone in CMV expression vector: NM_005322 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005322

    UniProtKB/Swiss-Prot: H15_HUMAN, P16401
    Function: Histones H1 are necessary for the condensation of nucleosome chains into higher order
    structures

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding NAS--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    3 Millipore Pathways for HIST1H1B
     Histone modification
     Cell cycle Start of DNA replication in early S phase
     Cell cycle Chromosome condensation in prometaphase

       GeneDecks  HIST1H1B for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  HIST1H1B 


    5/7 Interacting proteins for HIST1H1B (ENSP000003300743) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GSK3BENSP000003248063STRING (score=.852)
    GSK3AENSP000002223303STRING (score=.835)
    HIST2H2BEENSP000003364173STRING (score=.833)
    CDK2ENSP000002669703STRING (score=.802)
    RPS6KA5ENSP000002619913STRING (score=.765)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334 nucleosome assembly NAS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for HIST1H1B
    4 Novoseek chemical compound relationships for HIST1H1B gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 15.65 1 11724296 (1)
    nacl 14.00 7 1314829 (2), 17498293 (2), 2268409 (1)
    calcium 4.84 5 9109385 (2), 7626064 (1)
    atp 0.00 5 9109385 (2), 1945884 (1), 1426271 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (HIST1H1B)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HIST1H1B)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005322

                  Sigma-Aldrich siRNA for HIST1H1B  
                         Sigma-Aldrich shRNA for HIST1H1B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005322  

    REFSEQ mRNAs for HIST1H1B gene: 

    NM_005322.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005322  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005322
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005322
                                     untagged cDNA clone in CMV expression vector: NM_005322 

    Additional cDNA sequence: 

    BC069101.1 BC101581.1 BC101583.1 

    1 DOTS entry:

    DT.95174953 

    5 AceView cDNA sequences:

    NM_005322 BC069101 BX281309 BG292093 AA702996 

    highest scoring ESTs for HIST1H1B:

    BC069101 BG292093 BX281309 AA702996 NM_005322 BC101581 BC101583 BF807041 AI077628 Z98744 

    Unigene Cluster for HIST1H1B:

    Histone cluster 1, H1b
    Hs.131956  [show with all ESTs]
    Unigene Representative Sequence: BG292093


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000331442  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    HIST1H1B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for HIST1H1B

    1 / 2 / 3

    3 probe-sets matching HIST1H1B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    31750_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 Z98744 0.20 0.17 0.18 1

    214534_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005322 0.60 1.00 0.82 1

    214534_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TCGGAAACCG

    SOURCE GeneReport for Unigene cluster: Hs.131956

    Expression variation in blood from EXPOLDB for HIST1H1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for HIST1H1B gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4883051   -- similar to Histone H1.5 (Histone H1a) 84.04(n)
    95.26(a)
    488305  XM_545427.2  XP_545427.2 
    chimpanzee
    (Pan troglodytes)
    LOC4719061   -- similar to Histone H1.5 99.41(n)
    99.56(a)
    471906  XM_527284.2  XP_527284.1 
    cow
    (Bos taurus)
    LOC5273041   -- similar to Histone H1.5 (Histone H1a) 84.66(n)
    94.69(a)
    527304  XM_605694.3  XP_605694.2 
    rat
    (Rattus norvegicus)
    Hist1h1b1   -- histone cluster 1, H1b 78.68(n)
    89.64(a)
    680522  XM_001057550.1  XP_001057550.1 
    mouse
    (Mus musculus)
    Hist1h1b1, 5 135
    histone cluster 1, H1b1, 5 79.82(n)1
    91.93(a)1
    567021  NM_020034.11  NP_064418.11 
     AK0201175  AL5896515  (see all 11)
    About this table        Species with no ortholog for HIST1H1B

    ENSEMBL Gene Tree for HIST1H1B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for HIST1H1B gene
    HIST1H1E2  HIST1H1T2  HIST1H1D2  HIST1H1C2  HIST1H1A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/29 NCBI SNPs in HIST1H1B are shown (see all 29 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 36)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs2009491,2
    A,C,F,H,O27943414(+) AATCCA/GCCGCC 1 -- ng3110Minor allele frequency- G:0.15EA NA EU WA 620
    rs2009511,2
    A,C,F,H,O27943909(+) GTGCTA/GATGTC 1 -- ng3117Minor allele frequency- G:0.43NA EU EA WA 1540
    rs2009531,2
    A,C,F,H,O27945246(+) CTTCAT/CGAGCA 1 -- ng317Minor allele frequency- C:0.12EU EA WA NA 552
    rs2009501,2
    A,C,F,O27943751(+) TTGCAA/GGAGAA 1 -- ng31 trp33Minor allele frequency- G:0.09NA 142
    rs119706381,2
    C,F,H27942856(+) CAGCCT/CTCTTG 1 R/K mis18Minor allele frequency- C:0.01EU EA WA 838
    rs131997721,2
    C,F,H27942064(+) aaaaaA/GaTAAT 1 -- ng514Minor allele frequency- G:0.03EU EA WA 418
    rs131999061,2
    F,H27942118(+) AGACCC/GCATCT 1 -- ng516Minor allele frequency- G:0.04EU EA WA NA 602
    rs341444781,2
    C,F27942656(+) TTTTGC/TTGCTT 1 A/T mis15Minor allele frequency- T:0.02NA EU EA WA 496
    rs2009461,2
    C,H27942224(+) TAAACG/ACGGAA 1 -- ng515Minor allele frequency- A:0.00MN EU EA WA 602
    rs176957581,2
    F,H27945162(+) TGTTAT/CAAATT 1 -- ng31 tfbs37Minor allele frequency- C:0.03NA EU EA WA 562
    About this table

    HapMap Linkage Disequilibrium images for HIST1H1B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 142711

    2 Novoseek disease relationships for HIST1H1B gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 24.70 1 10373485 (1)
    lupus erythematosus systemic 12.21 1 12475000 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/141 PubMed articles for HIST1H1B gene (see all 141 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 3009 HGNC: 4719 AceView: HIST1H1B Ensembl:ENSG00000184357 euGenes: HUgn3009
    ECgene: HIST1H1B H-InvDB: HIST1H1B
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for HIST1H1B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Millipore Custom Antibody & Bulk Services
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     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for HIST1H1B Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for HIST1H1B Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (Histone H1.5, Histone H1, Histones)
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     Search OriGene for HIST1H1B
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     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for HIST1H1B

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