Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HIST1H1B Gene

protein-coding GIFtS: 57
GCID: GC06M027835

histone cluster 1, H1b

(Previous names: H1 histone family, member 5, histone 1, H1b )
(Previous symbol: H1F5)

Explore 16 diseases affiliated with
HIST1H1B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histone Cluster 1, H1b¹ ²		Histone H1b² ³
H1F5¹ ² ³ ⁵		Histone H1s-3² ³
H1.5¹ ²		H1b¹
H1s-3¹ ²		H1²
H1 Histone Family, Member 5¹ ²		H1B²
Histone 1, H1b¹ ²		Histone H1.5²
Histone H1a² ³

External Ids:	HGNC: 4719¹	Entrez Gene: 3009²	Ensembl: ENSG00000184357⁷	OMIM: 142711⁵	UniProtKB: P16401³

Export aliases for HIST1H1B gene to outside databases

Previous GC identifers: GC06M027893 GC06M027942 GC06M027644

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H1B:

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two

molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp

of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between

nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and

encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a

palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H15_HUMAN, P16401

Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the

chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured

fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and

DNA methylation (By similarity)

Gene Wiki entry for HIST1H1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HIST1H1B gene promoter:
Egr-3 E2F-3a E2F-4 E2F-5 Tal-1 Brachyury E2F-2 E47 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H1B promoter sequence

Search SABiosciences Chromatin IP Primers for HIST1H1B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.1

HIST1H1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1B gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M027835: view genomic region (about GC identifiers)

Start:	27,834,570 bp from pter	End:	27,835,425 bp from pter
Size:	856 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H15_HUMAN, P16401 (See protein sequence)

Recommended Name: Histone H1.5

Size: 226 amino acids; 22580 Da

Subcellular location: Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin.

According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin

2 PDB 3D structures from and Proteopedia for HIST1H1B:

2FE2 (3D)

2RHI (3D)

Secondary accessions: Q14529 Q3MJ42

Explore the universe of human proteins at neXtProt for HIST1H1B: NX_P16401

Post-translational modifications:

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2

phase and M phase, and being dephosphorylated sharply thereafter (By similarity). Phosphorylated at Thr-11 by GSK3B

during mitosis in prometaphase and dephosphorylated in telophase¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P16401

HIST1H1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005313.1

ENSEMBL proteins:

ENSP00000330074

Reactome Protein details: P16401
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: HIST1H1B OriGene Custom Protein Services for HIST1H1B
	GenScript Custom Purified and Recombinant Proteins Services for HIST1H1B
	Novus Biologicals HIST1H1B Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HIST1H1B

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	NAS	--
GO:0000790	nuclear chromatin	IDA	19882353

HIST1H1B for ontologies About GeneDecksing

HIST1H1B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H1B
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HIST1H1B
	GenScript Custom Superior Antibodies Services for HIST1H1B
	Novus Biologicals HIST1H1B Antibodies
	Search for Antibodies for HIST1H1B at Abcam
	Uscn Antibodies for HIST1H1B
	ThermoFisher Antibodies for HIST1H1B

Assay Products for HIST1H1B:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HIST1H1B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HIST1H1B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HIST1H1B for domains About GeneDecksing

3 InterPro domains/families:

IPR005819 Histone_H5

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR005818 Histone_H1/H5

Graphical View of Domain Structure for InterPro Entry P16401

ProtoNet protein and cluster: P16401

1 Blocks protein family: IPB005818 Histone H1/H5

UniProtKB/Swiss-Prot: H15_HUMAN, P16401

Domain: The C-terminal domain is required for high-affinity binding to chromatin (By similarity)

Similarity: Belongs to the histone H1/H5 family

Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: H15_HUMAN, P16401

Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the

chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured

fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and

DNA methylation (By similarity)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H1B
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H1B:
		hsa-miR-146a* hsa-miR-1276 hsa-miR-1293 hsa-miR-4260
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H1B (see all 7) OriGene shRNA RFP: HIST1H1B OriGene siRNA: HIST1H1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H1B

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for HIST1H1B

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HIST1H1B (NM_005322)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H1B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HIST1H1B
		Search LifeMap BioReagents cell lines for HIST1H1B

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1B

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	NAS	--

HIST1H1B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for HIST1H1B:

Increased circadian rhythm amp

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of DNA fragmentation factor

	Activation of DNA fragmentation factor	1.00			Granzyme-A Pathway	0.32
	Apoptosis induced DNA fragmentation	1.00

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Cell cycle Chromosome condensation in prometaphase

Cell cycle Chromosome condensation in prometaphase

1.00

Cell cycle_Chromosome condensation in prometaphase

1.00

Apoptotic cleavage of cellular proteins

Apoptotic execution phase

0.73

Activation of cAMP-Dependent PKA

PKA Signaling

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HIST1H1B

	Histone modification
	Cell cycle Start of DNA replication in early S phase
	Cell cycle Chromosome condensation in prometaphase

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H1B

	PKA Signaling
	Granzyme-A Pathway

2 GeneGo (Thomson Reuters) Pathways for HIST1H1B

	Cell cycle Chromosome condensation in prometaphase
	Cell cycle Start of DNA replication in early S phase

4 Reactome Pathways for HIST1H1B

	Activation of DNA fragmentation factor
	Apoptosis induced DNA fragmentation
	Apoptotic execution phase
	Apoptosis

HIST1H1B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HIST1H1B

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/44 Interacting proteins for HIST1H1B (P16401^{2, 3} ENSP00000330074⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
H3F3A	P84243³, ENSP00000355778⁴	I2D: score=1 STRING: ENSP00000355778
SIRT1	Q96EB6³, ENSP00000212015⁴	I2D: score=2 STRING: ENSP00000212015
CDK2	P24941³, ENSP00000266970⁴	I2D: score=1 STRING: ENSP00000266970
H3F3B	P84243³	I2D: score=1
L3MBTL1	Q9Y468³, ENSP00000362227⁴	I2D: score=1 STRING: ENSP00000362227

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	NAS	--

HIST1H1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

HIST1H1B for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HIST1H1B
4 Novoseek chemical compound relationships for HIST1H1B gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	13.9	1	11724296 (1)
nacl	12.2	7	1314829 (2), 17498293 (2), 2268409 (1)
calcium	4.77	5	9109385 (2), 7626064 (1)
atp	0	5	9109385 (2), 1945884 (1), 1426271 (1)

Search CenterWatch for drugs/clinical trials and news about HIST1H1B / H15

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HIST1H1B gene:

NM_005322.2

Unigene Cluster for HIST1H1B:

Histone cluster 1, H1b

Hs.131956 [show with all ESTs]

Unigene Representative Sequence: BG292093

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000331442(uc003njx.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H1B
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate HIST1H1B:
		hsa-miR-146a* hsa-miR-1276 hsa-miR-1293 hsa-miR-4260
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H1B (see all 7) OriGene shRNA RFP: HIST1H1B OriGene siRNA: HIST1H1B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H1B

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1B (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1B OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HIST1H1B (NM_005322)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIST1H1B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HIST1H1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H1B

Additional cDNA sequence:

BC069101.1 BC101581.1 BC101583.1

1 DOTS entry:

DT.95174953

5 AceView cDNA sequences:

NM_005322 BC069101 BX281309 BG292093 AA702996

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HIST1H1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGGAAACCG

About this image

HIST1H1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Hypothalamus

Brain

Neural Tube

Diencephalic Ventricular Zone

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

See HIST1H1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIST1H1B

SOURCE GeneReport for Unigene cluster: Hs.131956

UniProtKB/Swiss-Prot: H15_HUMAN, P16401

Tissue specificity: Ubiquitous. Expressed in the majority of the cell lines tested and in testis

SABiosciences Custom PCR Arrays for HIST1H1B

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H1B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HIST1H1B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H1B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H1B

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H1B gene from 9/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC427882¹	histone H1	71.91(n) 77.78(a)		427882 XM_425456.3 XP_425456.1
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	85(a) 62(a) (see all 4)	many ↔ many many ↔ many (see all 4)	GL343400.1(426161-426382) GL343279.1(541498-542142)
African clawed frog (Xenopus laevis)	Amphibia	Xl.8334²	Xenopus laevis transcribed sequence with weak similarity more	75.24(n)		48059871
zebrafish (Danio rerio)	Actinopterygii	LOC562307¹	uncharacterized LOC562307	69.54(n) 75.13(a)		562307 XM_703105.1 XP_708197.1
fruit fly (Drosophila melanogaster)	Insecta	His1:CG33855¹	CG33855-PA	48.48(n) 45(a)		3771991 NM_001032198.1 NP_001027369.1
worm (Caenorhabditis elegans)	Secernentea	hil-1⁶	Histone H1.X	16(a)	possible ortholog	V(14949760-14952775)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	HHO1¹	Hho1p	47.49(n) 39.73(a)		855976 NP_015198.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G06760¹	histone H1.1	47.71(n) 40.76(a)		837187 NM_100553.2 NP_172161.1
rice (Oryza sativa)	Liliopsida	Os03g0799000¹	hypothetical protein	53.01(n) 48.78(a)		4334439 NM_001058108.1 NP_001051573.1

ENSEMBL Gene Tree for HIST1H1B (if available)
TreeFam Gene Tree for HIST1H1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HIST1H1B gene

HIST1H1T² HIST1H1E² HIST1H1D² H1F0² HIST1H1C² H1FOO² H1FX² HIST1H1A²

7 SIMAP similar genes for HIST1H1B using alignment to 1 protein entry: H15_HUMAN:

HIST1H1E HIST1H1C HIST1H1D HIST1H1A HIST1H1T H1F0

H1FX

HIST1H1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73740859^1,2	C,	--	27834075(+)	`ACTTGA/TGGAAA`	2	--	ds500¹		2		WA	120
rs13199772^1,2	C,F,H,	--	27834085(+)	`AAAAAA/GATAAT`	1	--	ds500¹		9		NS EA NA	924
rs181969845^1,2		--	27834104(+)	`GAATGA/GCACGG`	1	--	ds500¹		0	--	--	--	--
rs142208525^1,2		--	27834107(+)	`TGACAC/TGGTCA`	1	--	ds500¹		0	--	--	--	--
rs199927247^1,2		--	27834122(+)	`AAATT-/GGCATG`	1	--	ds500¹		0	--	--	--	--
rs201265112^1,2	C	--	27834124(+)	`ATTGGA/CATGTA`	1	--	ds500¹		0	--	--	--	--
rs13199906^1,2	C,F,H,	--	27834139(+)	`AGACCC/GCATCT`	1	--	ds500¹		9		NS EA NA	726
rs150783751^1,2		--	27834177(+)	`CGTTGA/GTAGCA`	1	--	ds500¹		0	--	--	--	--
rs72847361^1,2	C,F,	--	27834216(+)	`ACGCCG/TAAGTA`	1	--	ds500¹		1		NA	120
rs200946^1,2	C,F,H,	--	27834245(+)	`TAAACG/ACGGAA`	1	--	ds500¹		9		MN NS EA NA	1206

HapMap Linkage Disequilibrium report for HIST1H1B (27834570 - 27835425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HIST1H1B: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H1B

DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H1B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HIST1H1B for disorders           About GeneDecksing

OMIM gene information: 142711    OMIM disorders: --

16 diseases for HIST1H1B:    About MalaCards

human t-cell leukemia virus type 1 ataxia telangiectasia primary hyperoxaluria lupus erythematosus

systemic lupus erythematosus t-cell leukemia ataxia measles

alzheimer's disease leukemia arthritis retinoblastoma

prostate cancer breast cancer melanoma prostatitis

1 disease from the University of Copenhagen DISEASES database for HIST1H1B:

Measles

2 Novoseek disease relationships for HIST1H1B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ataxia telangiectasia	22.9	1	10373485 (1)
lupus erythematosus systemic	10.3	1	12475000 (1)

Human Genome Epidemiology (HuGE) Navigator: HIST1H1B (1 document)

Export disorders for HIST1H1B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HIST1H1B gene, integrated from 9 sources (see all 187):
(articles sorted by number of sources associating them with HIST1H1B)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PubMed id 9031620)^{1, 2, 3, 9} Albig W.... Doenecke D. (1997)
The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F....Maltais L.J. (2002)
M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3. (PubMed id 19136008)^{1, 2, 9} Happel N....Doenecke D. (2009)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Distribution of somatic H1 subtypes is non-random on a ctive vs. inactive chromatin II: distribution in human adult fibroblasts. (PubMed id 11746507)^{1, 2} Parseghian M.H....Hamkalo B.A. (2001)
The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PubMed id 10997781)^{1, 2} Parseghian M.H....Hamkalo B.A. (2000)
Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)^{1, 3} Albig W.... Doenecke D. (1997)
Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d. (PubMed id 2613692)^{1, 2} Ohe Y.... Iwai K. (1989)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3009	HGNC: 4719	AceView: HIST1H1B	Ensembl:ENSG00000184357	euGenes: HUgn3009
ECgene: HIST1H1B	H-InvDB: HIST1H1B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HIST1H1B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HIST1H1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HIST1H1B gene:
Search GeneIP for patents involving HIST1H1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of HIST1H1B

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for HIST1H1B
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H1B		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIST1H1B
	OriGene Protein Over-expression Lysate for HIST1H1B		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HIST1H1B		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1B		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1B
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HIST1H1B		OriGene Custom Protein Services for HIST1H1B
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIST1H1B
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIST1H1B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H1B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIST1H1B
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H1B
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H1B

	GenScript Custom Purified and Recombinant Proteins Services for HIST1H1B		GenScript cDNA clones with any tag delivered in your preferred vector for HIST1H1B
	GenScript Custom Assay Services for HIST1H1B		GenScript Custom Superior Antibodies Services for HIST1H1B
	GenScript Custom overexpressing Cell Line Services for HIST1H1B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in HIST1H1B promoter
	Search Chromatin IP Primers for HIST1H1B
	RT² qPCR Primer Assay in human, mouse, rat HIST1H1B
	GNC Network for HIST1H1B
	SABiosciences PCR Arrays including human, mouse, rat HIST1H1B

Search Tocris compounds for HIST1H1B

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HIST1H1B antibodies
	HIST1H1B lysates

	Search for Antibodies for HIST1H1B at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for HIST1H1B
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

HIST1H1B Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HIST1H1B

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1B

	Browse SwitchGear 3'UTR luciferase reporter plasmids for HIST1H1B
	SwitchGear Promoter luciferase reporter plasmids for HIST1H1B

ThermoFisher Antibodies for HIST1H1B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIST1H1B

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HIST1H1B gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

HIST1H1B Gene

histone cluster 1, H1b

Aliases
for HIST1H1B gene

Summaries
for HIST1H1B gene

Genomic Views
for HIST1H1B gene

Proteins
for HIST1H1B gene

Protein Domains /
Families
for HIST1H1B gene

Function
for HIST1H1B gene

Pathways & Interactions
for HIST1H1B gene

Drugs & Compounds
for HIST1H1B gene

Transcripts
for HIST1H1B gene

Expression
for HIST1H1B gene

Orthologs
for HIST1H1B gene

Paralogs
for HIST1H1B gene

Genomic Variants
for HIST1H1B gene

Disorders / Diseases
for HIST1H1B gene

Publications
for HIST1H1B gene

External Searches for HIST1H1B gene

Genome Databases showing HIST1H1B gene

Other Databases showing HIST1H1B gene

Specialized Databases showing HIST1H1B gene

Intellectual Property
for HIST1H1B gene

Products
for HIST1H1B gene

View Random Gene

Advanced Search

Export list of displayed genes

HIST1H1B Gene

histone cluster 1, H1b

Aliasesfor HIST1H1B gene

Summariesfor HIST1H1B gene

Genomic Viewsfor HIST1H1B gene

Proteinsfor HIST1H1B gene

Protein Domains /Familiesfor HIST1H1B gene

Functionfor HIST1H1B gene

Pathways & Interactionsfor HIST1H1B gene

Drugs & Compoundsfor HIST1H1B gene

Transcriptsfor HIST1H1B gene

Expression for HIST1H1B gene

Orthologsfor HIST1H1B gene

Paralogsfor HIST1H1B gene

Genomic Variantsfor HIST1H1B gene

Disorders / Diseasesfor HIST1H1B gene

Publicationsfor HIST1H1B gene

External Searches for HIST1H1B gene

Genome Databases showing HIST1H1B gene

Other Databases showing HIST1H1B gene

Specialized Databases showing HIST1H1B gene

Intellectual Propertyfor HIST1H1B gene

Productsfor HIST1H1B gene

View Random Gene

Aliases
for HIST1H1B gene

Summaries
for HIST1H1B gene

Genomic Views
for HIST1H1B gene

Proteins
for HIST1H1B gene

Protein Domains /
Families
for HIST1H1B gene

Function
for HIST1H1B gene

Pathways & Interactions
for HIST1H1B gene

Drugs & Compounds
for HIST1H1B gene

Transcripts
for HIST1H1B gene

Expression
for HIST1H1B gene

Orthologs
for HIST1H1B gene

Paralogs
for HIST1H1B gene

Genomic Variants
for HIST1H1B gene

Disorders / Diseases
for HIST1H1B gene

Publications
for HIST1H1B gene

Intellectual Property
for HIST1H1B gene

Products
for HIST1H1B gene