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HIST1H1B Gene

protein-coding   GIFtS: 63
GCID: GC06M027835

Histone Cluster 1, H1b

(Previous names: H1 histone family, member 5, histone 1, H1b)
(Previous symbol: H1F5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H1b1 2     Histone H1s-32 3
H1F51 2 3 5     H12
H1 Histone Family, Member 51 2     H1.52
Histone 1, H1b1 2     H1B2
Histone H1a2 3     H1s-32
Histone H1b2 3     Histone H1.52

External Ids:    HGNC: 47191   Entrez Gene: 30092   Ensembl: ENSG000001843577   OMIM: 1427115   UniProtKB: P164013   

Export aliases for HIST1H1B gene to outside databases

Previous GC identifers: GC06M027893 GC06M027942 GC06M027644


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H1B Gene:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes.
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster
on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H1B Gene:
HIST1H1B (histone cluster 1, H1b) is a protein-coding gene. Diseases associated with HIST1H1B include human t-cell leukemia virus type 1, and primary hyperoxaluria. An important paralog of this gene is HIST1H1T.

UniProtKB/Swiss-Prot: H15_HUMAN, P16401
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
nucleosome spacing and DNA methylation (By similarity)

Gene Wiki entry for HIST1H1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H1B gene promoter:
         Egr-3   E2F-3a   E2F-4   E2F-5   Tal-1   Brachyury   E2F-2   E47   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H1B promoter sequence
   Search Chromatin IP Primers for HIST1H1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027835:  view genomic region     (about GC identifiers)

Start:
27,834,570 bp from pter      End:
27,835,359 bp from pter
Size:
790 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H15_HUMAN, P16401 (See protein sequence)
Recommended Name: Histone H1.5  
Size: 226 amino acids; 22580 Da
2 PDB 3D structures from and Proteopedia for HIST1H1B:
2FE2 (3D)        2RHI (3D)    
Secondary accessions: Q14529 Q3MJ42

Explore the universe of human proteins at neXtProt for HIST1H1B: NX_P16401

Explore proteomics data for HIST1H1B at MOPED

Post-translational modifications: 

  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late
    G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity). Phosphorylated at Thr-11 by
    GSK3B during mitosis in prometaphase and dephosphorylated in telophase1
  • Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its
    displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell
    maintenance (By similarity)1
  • Ubiquitination2 at Lys17, Lys37, Lys49, Lys67, Lys78, Lys88, Lys93, Lys100, Lys109
  • Modification sites at PhosphoSitePlus

  • See HIST1H1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005313.1  
    ENSEMBL proteins: 
     ENSP00000330074  
    Reactome Protein details: P16401

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR005819 Histone_H5
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5_H15

    Graphical View of Domain Structure for InterPro Entry P16401

    ProtoNet protein and cluster: P16401

    1 Blocks protein domain: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H15_HUMAN, P16401
    Domain: The C-terminal domain is required for high-affinity binding to chromatin (By similarity)
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    HIST1H1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H15_HUMAN, P16401
    Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
    the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
    structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
    nucleosome spacing and DNA methylation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    HIST1H1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HIST1H1B:
     Increased circadian rhythm amp  Increased gamma-H2AX phosphory 

    Animal Models:
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    miRTarBase miRNAs that target HIST1H1B:
    hsa-mir-3615 (MIRT052852), hsa-mir-193b-3p (MIRT041257), hsa-mir-34a-5p (MIRT025285), hsa-mir-1 (MIRT023593)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H15_HUMAN, P16401: Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in
    heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not
    heterochromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0000790nuclear chromatin IDA19882353
    GO:0005634nucleus ----

    HIST1H1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H1B About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor0.32
    Apoptosis induced DNA fragmentation0.00
    Granzyme-A Pathway0.32
    2Packaging Of Telomere Ends
    DNA Damage/Telomere Stress Induced Senescence0.65
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)0.00
    Histone modification0.31
    3Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    4Apoptotic cleavage of cellular proteins
    Apoptotic execution phase0.74
    5Activation of cAMP-Dependent PKA
    PKA Signaling0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H1B
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1B
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase

    2 Reactome Pathways for HIST1H1B
        Activation of DNA fragmentation factor
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)



    HIST1H1B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H1B
    Interactions:

        GeneGlobe Interaction Network for HIST1H1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H1B (P164012, 3 ENSP000003300744) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EHMT2Q96KQ73, ENSP000003646874I2D: score=1 STRING: ENSP00000364687
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000227333Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--

    HIST1H1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H1B (H15)

    4 Novoseek inferred chemical compound relationships for HIST1H1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 13.9 1 11724296 (1)
    nacl 12.2 7 1314829 (2), 17498293 (2), 2268409 (1)
    calcium 4.77 5 9109385 (2), 7626064 (1)
    atp 0 5 9109385 (2), 1945884 (1), 1426271 (1)



    HIST1H1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIST1H1B gene: 
    NM_005322.2  

    Unigene Cluster for HIST1H1B:

    Histone cluster 1, H1b
    Hs.131956  [show with all ESTs]
    Unigene Representative Sequence: BG292093
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331442(uc003njx.3)
    miRNA
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    Additional mRNA sequence: 

    BC069101.1 BC101581.1 BC101583.1 

    1 DOTS entry:

    DT.95174953 

    5 AceView cDNA sequences:

    NM_005322 BC069101 BX281309 BG292093 AA702996 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGAAACCG
    HIST1H1B Expression
    About this image


    HIST1H1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
     
     Brain (Nervous System)
             Hypothalamus
    HIST1H1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131956

    UniProtKB/Swiss-Prot: H15_HUMAN, P16401
    Tissue specificity: Ubiquitous. Expressed in the majority of the cell lines tested and in testis

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H1B gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h1b5 histone cluster 1, H1b   --   13 (7.97 cM) 21779883 
    chicken
    (Gallus gallus)
    Aves HIST1H111L6
    HIST1H111R6
    (see all 3)
    Gallus gallus histone cluster 1, H1.11L (similar t...
    Gallus gallus histone cluster 1, H1.11R (similar t...
    (see all 3)
    76(a)
    76(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    1(48025516-48026285)
    1(48033617-48034276)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83342 Xenopus laevis transcribed sequence with weak similarity more 75.24(n)    48059871 
    zebrafish
    (Danio rerio)
    Actinopterygii CU457819.36
    CABZ01086354.16
    (see all 15)
    Uncharacterized protein
    (see all 15)
    72(a)
    70(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    7(7179641-7180171) ENSDARG00000090426
    25(36182655-36183146) ENSDARG00000092395


    ENSEMBL Gene Tree for HIST1H1B (if available)
    TreeFam Gene Tree for HIST1H1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H1B gene
    HIST1H1T2  HIST1H1E2  H1F02  HIST1H1D2  HIST1H1C2  HIST1H1A2  
    7 SIMAP similar genes for HIST1H1B using alignment to 1 protein entry:     H15_HUMAN:
    HIST1H1E    HIST1H1C    HIST1H1D    HIST1H1A    HIST1H1T    H1F0
    H1FX

    HIST1H1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H1B (see all 140)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362044
    A colorectal cancer sample4--see VAR_0362042 G D mis40--------
    rs131997721,2
    C,F,H--27834085(+) AAAAAA/GATAAT 1 -- ds50019Minor allele frequency- G:0.04NS EA NA 924
    rs1819698451,2
    --27834104(+) GAATGA/GCACGG 1 -- ds50010--------
    rs1422085251,2
    C--27834107(+) TGACAC/TGGTCA 1 -- ds50010--------
    rs1999272471,2
    --27834122(+) AAATT-/GGCATG 1 -- ds50010--------
    rs2012651121,2
    C--27834124(+) ATTGGA/CATGTA 1 -- ds50010--------
    rs131999061,2
    C,F,H--27834139(+) AGACCC/GCATCT 1 -- ds50019Minor allele frequency- G:0.06NS EA NA 726
    rs1507837511,2
    C--27834177(+) CGTTGA/GTAGCA 1 -- ds50010--------
    rs728473611,2
    C,F--27834216(+) ACGCCG/TAAGTA 1 -- ds50011Minor allele frequency- T:0.07NA 120
    rs2009461,2
    C,F,H--27834245(+) TAAACG/ACGGAA 1 -- ds50019Minor allele frequency- A:0.06MN NS EA NA 1206

    HapMap Linkage Disequilibrium report for HIST1H1B (27834570 - 27835359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv883512CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIST1H1B
    DNA2.0 Custom Variant and Variant Library Synthesis for HIST1H1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142711    OMIM disorders: --

    Selected diseases for HIST1H1B (see all 23):    
    About MalaCards
    human t-cell leukemia virus type 1    primary hyperoxaluria    pulmonary neuroendocrine tumor    ataxia telangiectasia
    measles    lupus erythematosus    ataxia    t-cell leukemia
    neuroendocrine tumor    breast and colorectal cancer    systemic lupus erythematosus    retinoblastoma
    alzheimer's disease    malaria    melanoma    leukemia
    arthritis    prostate cancer    neuroblastoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for HIST1H1B:
    Measles

    HIST1H1B for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for HIST1H1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 22.9 1 10373485 (1)
    lupus erythematosus systemic 10.3 1 12475000 (1)

    Genetic Association Database (GAD): HIST1H1B
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1B (1 document)

    Export disorders for HIST1H1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H1B gene, integrated from 10 sources (see all 212):
    (articles sorted by number of sources associating them with HIST1H1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PubMed id 9031620)1, 2, 3, 9 Albig W.... Doenecke D. (Gene 1997)
    2. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    3. M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3. (PubMed id 19136008)1, 2, 9 Happel N.... Doenecke D. (J. Mol. Biol. 2009)
    4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    8. Distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin II: distribution in human adult fibroblasts. (PubMed id 11746507)1, 2 Parseghian M.H.... Hamkalo B.A. (J. Cell. Biochem. 2001)
    9. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PubMed id 10997781)1, 2 Parseghian M.H.... Hamkalo B.A. (Chromosome Res. 2000)
    10. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 3 Albig W.... Doenecke D. (Genomics 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3009 HGNC: 4719 AceView: HIST1H1B Ensembl:ENSG00000184357 euGenes: HUgn3009
    ECgene: HIST1H1B H-InvDB: HIST1H1B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HIST1H1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HIST1H1B gene:
    Search GeneIP for patents involving HIST1H1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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