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Aliases for HIST1H1B Gene

Aliases for HIST1H1B Gene

  • Histone Cluster 1 H1 Family Member B 2 3 5
  • H1 Histone Family, Member 5 2 3
  • Histone Cluster 1, H1b 2 3
  • Histone 1, H1b 2 3
  • Histone H1s-3 3 4
  • Histone H1a 3 4
  • Histone H1b 3 4
  • H1F5 3 4
  • Histone H1.5 3
  • H1s-3 3
  • H1.5 3
  • H1B 3
  • H1 3

External Ids for HIST1H1B Gene

Previous HGNC Symbols for HIST1H1B Gene

  • H1F5

Previous GeneCards Identifiers for HIST1H1B Gene

  • GC06M027893
  • GC06M027942
  • GC06M027835
  • GC06M027644
  • GC06M027894
  • GC06M027911
  • GC06M027934
  • GC06M028000

Summaries for HIST1H1B Gene

Entrez Gene Summary for HIST1H1B Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H1B Gene

HIST1H1B (Histone Cluster 1 H1 Family Member B) is a Protein Coding gene. Among its related pathways are Apoptosis induced DNA fragmentation and Regulation of activated PAK-2p34 by proteasome mediated degradation. GO annotations related to this gene include poly(A) RNA binding and chromatin DNA binding. An important paralog of this gene is HIST1H1E.

UniProtKB/Swiss-Prot for HIST1H1B Gene

  • Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Wiki entry for HIST1H1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1B Gene

Genomics for HIST1H1B Gene

Regulatory Elements for HIST1H1B Gene

Enhancers for HIST1H1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F027834 1.6 FANTOM5 ENCODE 9.2 +30.3 30289 6.4 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 SP3 NFYC TBX21 MEF2D ZNF610 ZKSCAN3 ZNF391 ZKSCAN4 ZKSCAN8 HNRNPA1P1 HIST1H2BPS2 OR2B2 CD83P1 LOC442172 GPX5
GH06F027821 1.2 ENCODE 11.4 +43.7 43676 4.6 CREB3L1 DMAP1 YY1 ZNF143 SP3 TBX21 MEF2D RCOR2 NBN KDM1A ZKSCAN8 ZNF391 ZNF204P ZKSCAN3 ENSG00000271755 HIST1H3J ZSCAN23 HIST1H1B HIST1H2BO HIST1H3I
GH06F027887 1.6 FANTOM5 ENCODE 4.2 -25.9 -25900 11.9 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 NFYC TBX21 SSRP1 ZNF610 RCOR2 ZNF603P ZKSCAN3 ZKSCAN8 ZKSCAN4 ZSCAN23 HIST1H4K HIST1H3H HIST1H2BN HIST1H2BL ZNF204P
GH06F027805 1.5 FANTOM5 ENCODE 2.7 +55.5 55467 12.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 NFYC TBX21 MEF2D SSRP1 ZNF603P ZNF391 ZNF204P ZNF192P1 ENSG00000271755 ZKSCAN3 ZKSCAN4 ZKSCAN8 ZSCAN23 PGBD1
GH06F027862 1.5 Ensembl ENCODE 0.8 -1.1 -1087 12.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 ZKSCAN8 ZKSCAN3 ZSCAN9 GUSBP2 ZSCAN26 ZKSCAN4 ZSCAN23 ZNF391 ZNF603P PGBD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIST1H1B on UCSC Golden Path with GeneCards custom track

Promoters for HIST1H1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001214452 1780 4800 HDGF ARNT MLX ARID4B SIN3A DMAP1 ZNF207 FOS PAF1 NFYC

Genomic Location for HIST1H1B Gene

Chromosome:
6
Start:
27,866,792 bp from pter
End:
27,867,581 bp from pter
Size:
790 bases
Orientation:
Minus strand

Genomic View for HIST1H1B Gene

Genes around HIST1H1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1B Gene

Proteins for HIST1H1B Gene

  • Protein details for HIST1H1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16401-H15_HUMAN
    Recommended name:
    Histone H1.5
    Protein Accession:
    P16401
    Secondary Accessions:
    • Q14529
    • Q3MJ42

    Protein attributes for HIST1H1B Gene

    Size:
    226 amino acids
    Molecular mass:
    22580 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HIST1H1B Gene

neXtProt entry for HIST1H1B Gene

Post-translational modifications for HIST1H1B Gene

  • Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity). Phosphorylated at Thr-11 by GSK3B during mitosis in prometaphase and dephosphorylated in telophase.
  • Ubiquitination at Lys 17, Lys 49, Lys 67, and Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIST1H1B Gene

Domains & Families for HIST1H1B Gene

Gene Families for HIST1H1B Gene

Protein Domains for HIST1H1B Gene

Suggested Antigen Peptide Sequences for HIST1H1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16401

UniProtKB/Swiss-Prot:

H15_HUMAN :
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Belongs to the histone H1/H5 family.
Domain:
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1B: view

Function for HIST1H1B Gene

Molecular function for HIST1H1B Gene

UniProtKB/Swiss-Prot Function:
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Ontology (GO) - Molecular Function for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0031490 chromatin DNA binding IMP 15911621
GO:0042826 histone deacetylase binding IPI 22956909
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HIST1H1B: view
genes like me logo Genes that share phenotypes with HIST1H1B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H1B Gene

Localization for HIST1H1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1B Gene

Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIST1H1B gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IDA 19882353
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005720 nuclear heterochromatin IDA 15911621
genes like me logo Genes that share ontologies with HIST1H1B: view

Pathways & Interactions for HIST1H1B Gene

genes like me logo Genes that share pathways with HIST1H1B: view

Pathways by source for HIST1H1B Gene

SIGNOR curated interactions for HIST1H1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22956909
GO:0006325 chromatin organization IMP 22956909
GO:0006334 nucleosome assembly IEA --
GO:0030307 positive regulation of cell growth IMP 22956909
GO:0050821 protein stabilization IMP 22956909
genes like me logo Genes that share ontologies with HIST1H1B: view

Drugs & Compounds for HIST1H1B Gene

(3) Drugs for HIST1H1B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for HIST1H1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HIST1H1B: view

Transcripts for HIST1H1B Gene

mRNA/cDNA for HIST1H1B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1B Gene

Histone cluster 1, H1b:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1B Gene

No ASD Table

Relevant External Links for HIST1H1B Gene

GeneLoc Exon Structure for
HIST1H1B
ECgene alternative splicing isoforms for
HIST1H1B

Expression for HIST1H1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HIST1H1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1B Gene

This gene is overexpressed in Whole Blood (x12.2) and Colon - Transverse (x4.0).

Protein differential expression in normal tissues from HIPED for HIST1H1B Gene

This gene is overexpressed in NK cells (10.1), Neutrophil (7.1), Fetal testis (6.5), and Fetal gut (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H1B Gene



Protein tissue co-expression partners for HIST1H1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HIST1H1B Gene:

HIST1H1B

SOURCE GeneReport for Unigene cluster for HIST1H1B Gene:

Hs.131956

mRNA Expression by UniProt/SwissProt for HIST1H1B Gene:

P16401-H15_HUMAN
Tissue specificity: Ubiquitous. Expressed in the majority of the cell lines tested and in testis.
genes like me logo Genes that share expression patterns with HIST1H1B: view

Primer Products

Orthologs for HIST1H1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIST1H1B 35
  • 100 (a)
OneToOne
LOC471906 34
  • 99.41 (n)
mouse
(Mus musculus)
Mammalia Hist1h1b 35
  • 92 (a)
OneToMany
Gm6970 35
  • 74 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC488305 34
  • 83.42 (n)
cow
(Bos Taurus)
Mammalia HIST1H1D 35
  • 83 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
ManyToMany
-- 35
  • 72 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 33 (a)
OneToMany
chicken
(Gallus gallus)
Aves HIST1H111L 35
  • 76 (a)
ManyToMany
HIST1H111R 35
  • 76 (a)
ManyToMany
-- 35
  • 68 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.8334 34
zebrafish
(Danio rerio)
Actinopterygii CU457819.3 35
  • 72 (a)
ManyToMany
CABZ01086354.1 35
  • 70 (a)
ManyToMany
FP325123.1 35
  • 70 (a)
ManyToMany
histh1l 35
  • 70 (a)
ManyToMany
si:dkey-261m9.12 35
  • 68 (a)
ManyToMany
zgc:110425 35
  • 68 (a)
ManyToMany
zgc:153405 35
  • 68 (a)
ManyToMany
si:ch211-113a14.12 35
  • 67 (a)
ManyToMany
si:ch211-113a14.18 35
  • 67 (a)
ManyToMany
si:ch211-113a14.24 35
  • 67 (a)
ManyToMany
si:dkey-108k21.14 35
  • 67 (a)
ManyToMany
si:dkey-108k21.10 35
  • 66 (a)
ManyToMany
zgc:163061 35 35
  • 65 (a)
ManyToMany
si:dkey-108k21.21 35
  • 61 (a)
ManyToMany
Species where no ortholog for HIST1H1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1B Gene

ENSEMBL:
Gene Tree for HIST1H1B (if available)
TreeFam:
Gene Tree for HIST1H1B (if available)

Paralogs for HIST1H1B Gene

Paralogs for HIST1H1B Gene

(7) SIMAP similar genes for HIST1H1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H1B: view

Variants for HIST1H1B Gene

Sequence variations from dbSNP and Humsavar for HIST1H1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036204 A colorectal cancer sample
rs111355715 -- 27,869,334(+) TAAAG(A/C)GTGTG upstream-variant-2KB
rs111653826 -- 27,868,101(+) ACCAC(A/G)TAGAC upstream-variant-2KB
rs112601932 -- 27,869,262(+) GATAG(C/T)AGCAC upstream-variant-2KB
rs112681696 -- 27,867,530(+) GACAT(A/G)GTGGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1B Gene

Variant ID Type Subtype PubMed ID
nsv601208 CNV loss 21841781

Variation tolerance for HIST1H1B Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIST1H1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1B Gene

Disorders for HIST1H1B Gene

Relevant External Links for HIST1H1B

Genetic Association Database (GAD)
HIST1H1B
Human Genome Epidemiology (HuGE) Navigator
HIST1H1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H1B

No disorders were found for HIST1H1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1B Gene

Publications for HIST1H1B Gene

  1. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PMID: 9031620) Albig W. … Doenecke D. (Gene 1997) 2 3 4 22 64
  2. M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3. (PMID: 19136008) Happel N. … Doenecke D. (J. Mol. Biol. 2009) 3 4 22 64
  3. Histone H1 phosphorylation occurs site-specifically during interphase and mitosis: identification of a novel phosphorylation site on histone H1. (PMID: 16377619) Sarg B. … Lindner H.H. (J. Biol. Chem. 2006) 3 4 22 64
  4. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64

Products for HIST1H1B Gene

Sources for HIST1H1B Gene

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