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Aliases for HIST1H1B Gene

Aliases for HIST1H1B Gene

  • Histone Cluster 1, H1b 2 3
  • H1F5 3 4 6
  • H1 Histone Family, Member 5 2 3
  • Histone 1, H1b 2 3
  • Histone H1s-3 3 4
  • Histone H1a 3 4
  • Histone H1b 3 4
  • Histone H1.5 3
  • H1s-3 3
  • H1.5 3
  • H1B 3
  • H1 3

External Ids for HIST1H1B Gene

Previous HGNC Symbols for HIST1H1B Gene

  • H1F5

Previous GeneCards Identifiers for HIST1H1B Gene

  • GC06M027893
  • GC06M027942
  • GC06M027835
  • GC06M027644

Summaries for HIST1H1B Gene

Entrez Gene Summary for HIST1H1B Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIST1H1B Gene

HIST1H1B (Histone Cluster 1, H1b) is a Protein Coding gene. Diseases associated with HIST1H1B include human t-cell leukemia virus type 1 and neuroendocrine tumor. Among its related pathways are Cellular Senescence and Cellular Senescence. An important paralog of this gene is HIST1H1D.

UniProtKB/Swiss-Prot for HIST1H1B Gene

  • Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Wiki entry for HIST1H1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1B Gene

Genomics for HIST1H1B Gene

Regulatory Elements for HIST1H1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIST1H1B Gene

27,866,792 bp from pter
27,867,581 bp from pter
790 bases
Minus strand

Genomic View for HIST1H1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIST1H1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1B Gene

Proteins for HIST1H1B Gene

  • Protein details for HIST1H1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histone H1.5
    Protein Accession:
    Secondary Accessions:
    • Q14529
    • Q3MJ42

    Protein attributes for HIST1H1B Gene

    226 amino acids
    Molecular mass:
    22580 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HIST1H1B Gene

neXtProt entry for HIST1H1B Gene

Proteomics data for HIST1H1B Gene at MOPED

Post-translational modifications for HIST1H1B Gene

  • Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity). Phosphorylated at Thr-11 by GSK3B during mitosis in prometaphase and dephosphorylated in telophase.
  • Ubiquitination at Lys17, Lys37, Lys49, Lys67, Lys78, Lys88, Lys93, Lys100, and Lys109
  • Modification sites at PhosphoSitePlus

Other Protein References for HIST1H1B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST1H1B Gene

Domains for HIST1H1B Gene

Gene Families for HIST1H1B Gene

  • HIST :Histones / Replication-dependent

Protein Domains for HIST1H1B Gene

Suggested Antigen Peptide Sequences for HIST1H1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P16401
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1B: view

Function for HIST1H1B Gene

Molecular function for HIST1H1B Gene

UniProtKB/Swiss-Prot Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Ontology (GO) - Molecular Function for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0031490 chromatin DNA binding IMP 15911621
GO:0042826 histone deacetylase binding IPI 22956909
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with HIST1H1B: view

Phenotypes for HIST1H1B Gene

genes like me logo Genes that share phenotypes with HIST1H1B: view

Animal Model Products

CRISPR Products

miRNA for HIST1H1B Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIST1H1B Gene

Localization for HIST1H1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1B Gene

Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not heterochromatin.

Subcellular locations from

Jensen Localization Image for HIST1H1B Gene COMPARTMENTS Subcellular localization image for HIST1H1B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IEA --
GO:0000790 nuclear chromatin IDA 19882353
GO:0005634 nucleus --
GO:0005720 nuclear heterochromatin IDA 15911621
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HIST1H1B: view

Pathways for HIST1H1B Gene

genes like me logo Genes that share pathways with HIST1H1B: view

Pathways by source for HIST1H1B Gene

Gene Ontology (GO) - Biological Process for HIST1H1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 22956909
GO:0006325 chromatin organization IMP 22956909
GO:0006334 nucleosome assembly IEA --
GO:0030307 positive regulation of cell growth IMP 22956909
GO:0050821 protein stabilization IMP 22956909
genes like me logo Genes that share ontologies with HIST1H1B: view

Compounds for HIST1H1B Gene

(4) Novoseek inferred chemical compound relationships for HIST1H1B Gene

Compound -log(P) Hits PubMed IDs
lysine 13.9 1
nacl 12.2 5
calcium 4.77 3
atp 0 4
genes like me logo Genes that share compounds with HIST1H1B: view

Transcripts for HIST1H1B Gene

mRNA/cDNA for HIST1H1B Gene

(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1B Gene

Histone cluster 1, H1b:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIST1H1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1B Gene

No ASD Table

Relevant External Links for HIST1H1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIST1H1B Gene

mRNA expression in normal human tissues for HIST1H1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1B Gene

This gene is overexpressed in Whole Blood (12.2) and Colon - Transverse (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H1B Gene

SOURCE GeneReport for Unigene cluster for HIST1H1B Gene Hs.131956

mRNA Expression by UniProt/SwissProt for HIST1H1B Gene

Tissue specificity: Ubiquitous. Expressed in the majority of the cell lines tested and in testis.
genes like me logo Genes that share expressions with HIST1H1B: view

In Situ Assay Products

Orthologs for HIST1H1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HIST1H1B 36
  • 100 (a)
LOC471906 35
  • 99.41 (n)
  • 99.56 (a)
(Bos Taurus)
Mammalia HIST1H1D 36
  • 83 (a)
(Canis familiaris)
Mammalia LOC488305 35
  • 83.42 (n)
  • 94.18 (a)
(Mus musculus)
Mammalia Gm6970 36
  • 74 (a)
Hist1h1b 16
Hist1h1b 36
  • 92 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
-- 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 33 (a)
(Gallus gallus)
Aves -- 36
  • 68 (a)
HIST1H111L 36
  • 76 (a)
HIST1H111R 36
  • 76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8334 35
(Danio rerio)
Actinopterygii CABZ01086354.1 36
  • 70 (a)
CU457819.3 36
  • 72 (a)
FP325123.1 36
  • 70 (a)
histh1l 36
  • 70 (a)
si:ch211-113a14.12 36
  • 67 (a)
si:ch211-113a14.18 36
  • 67 (a)
si:ch211-113a14.24 36
  • 67 (a)
si:dkey-108k21.10 36
  • 66 (a)
si:dkey-108k21.14 36
  • 67 (a)
si:dkey-108k21.21 36
  • 61 (a)
si:dkey-261m9.12 36
  • 68 (a)
zgc:110425 36
  • 68 (a)
zgc:153405 36
  • 68 (a)
zgc:163061 36
  • 65 (a)
zgc:163061 36
  • 66 (a)
Species with no ortholog for HIST1H1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1B Gene

Gene Tree for HIST1H1B (if available)
Gene Tree for HIST1H1B (if available)

Paralogs for HIST1H1B Gene

Paralogs for HIST1H1B Gene

Selected SIMAP similar genes for HIST1H1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H1B: view

Variants for HIST1H1B Gene

Sequence variations from dbSNP and Humsavar for HIST1H1B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs200946 -- 27,866,467(+) TAAAC(A/G)CGGAA downstream-variant-500B
rs200947 -- 27,867,353(+) GAAAG(C/G)CCATT reference, synonymous-codon
rs200948 -- 27,867,494(+) GGCGC(C/T)GGGGT reference, synonymous-codon
rs200949 -- 27,867,657(+) AATCC(A/G)CCGCC upstream-variant-2KB
rs200950 -- 27,867,994(+) TTGCA(A/G)GAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1B Gene

Variant ID Type Subtype PubMed ID
nsv883512 CNV Gain 21882294

Relevant External Links for HIST1H1B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1B Gene

Disorders for HIST1H1B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HIST1H1B Gene including...

Search for HIST1H1B Gene in MalaCards »

(1) University of Copenhagen DISEASES for HIST1H1B Gene

(2) Novoseek inferred disease relationships for HIST1H1B Gene

Disease -log(P) Hits PubMed IDs
ataxia telangiectasia 22.9 1
lupus erythematosus systemic 10.3 1

Relevant External Links for HIST1H1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HIST1H1B: view

No data available for UniProtKB/Swiss-Prot for HIST1H1B Gene

Publications for HIST1H1B Gene

  1. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PMID: 9031620) Albig W. … Doenecke D. (Gene 1997) 2 3 4 23
  2. M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3. (PMID: 19136008) Happel N. … Doenecke D. (J. Mol. Biol. 2009) 3 4 23
  3. Histone H1 phosphorylation occurs site-specifically during interphase and mitosis: identification of a novel phosphorylation site on histone H1. (PMID: 16377619) Sarg B. … Lindner H.H. (J. Biol. Chem. 2006) 3 4 23
  4. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for HIST1H1B Gene

Sources for HIST1H1B Gene

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