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Aliases & Descriptions for HIST1H1B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| H1 2 | | H1.5 1, 2 | | H1F5 2, 3, 5 | | MGC126630 2 | | MGC126632 2 | | OTTHUMP00000017748 2 |
| | | Descriptions |
|---|
| H1 histone family, member 5 1, 2 | | Histone H1a 3 | | histone 1, H1b 1, 2 | | histone cluster 1, H1b 2 |
|
| | Search outside databases for aliases for HIST1H1B genePrevious GC identifer: GC06M027893 |
Summaries for HIST1H1B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HIST1H1B: Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq] UniProtKB/Swiss-Prot: H15_HUMAN, P16401Function: Histones H1 are necessary for the condensation of nucleosome chains into higher order structuresGene Wiki entry for HIST1H1B |
Genomic Location for HIST1H1B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HIST1H1B gene 
Entrez Gene cytogenetic band: 6p22-p21.3 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p22.1HIST1H1B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M027942:
(about GC identifiers)
Start:
|
27,942,549 bp from pter |
End:
|
27,943,404 bp from pter |
Size:
|
856 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14
| Proteins for HIST1H1B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: H15_HUMAN, P16401 (See
protein sequence)Recommended Name: Histone H1.5 Size: 226 amino acids; 22580 Da
Subcellular location: Nucleus
PDB structure from and Proteopedia :2FE2 (3D)
 2RHI (3D)
 
Secondary accessions: Q14529 Q3MJ42Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005313.1
ENSEMBL proteins: ENSP00000330074
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for HIST1H1B: Assays for HIST1H1B: | Protein
Domains/ Families for HIST1H1B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P16401
ProtoNet protein and cluster: P16401 1 Blocks protein family: IPB005818 Histone H1/H5
UniProtKB/Swiss-Prot: H15_HUMAN, P16401Similarity: Belongs to the histone H1/H5 family | Gene Function for HIST1H1B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005322
Applied Biosystems Silencer® siRNAs for HIST1H1B
Sigma-Aldrich siRNA for HIST1H1B  Sigma-Aldrich shRNA for HIST1H1B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005322                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005322                                  untagged cDNA clone in CMV expression vector: NM_005322 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005322
UniProtKB/Swiss-Prot: H15_HUMAN, P16401Function: Histones H1 are necessary for the condensation of nucleosome chains into higher order structures1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
NAS | -- | About this table | Pathways & Interactions for HIST1H1B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for HIST1H1B 
5/7 Interacting proteins for HIST1H1B (ENSP000003300743) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006334 | nucleosome assembly |
NAS | -- | About this table
|
Drugs & Compounds for HIST1H1B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HIST1H1B 4 Novoseek chemical compound relationships for HIST1H1B gene
About this table
|
Transcripts for HIST1H1B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005322
Sigma-Aldrich siRNA for HIST1H1B  Sigma-Aldrich shRNA for HIST1H1B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005322 REFSEQ mRNAs for HIST1H1B gene: NM_005322.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005322               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005322                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005322                                  untagged cDNA clone in CMV expression vector: NM_005322  Additional cDNA sequence: BC069101.1 BC101581.1 BC101583.1 1 DOTS entry: DT.95174953 5 AceView cDNA sequences:NM_005322 BC069101 BX281309 BG292093 AA702996
highest scoring ESTs for HIST1H1B:BC069101 BG292093 BX281309 AA702996 NM_005322 BC101581 BC101583 BF807041 AI077628 Z98744 Unigene Cluster for HIST1H1B: Histone cluster 1, H1b Hs.131956 [show with all ESTs]Unigene Representative Sequence: BG292093
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000331442
|
Expression for HIST1H1B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HIST1H1B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HIST1H1B
1 / 2 / 3 3 probe-sets matching HIST1H1B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCGGAAACCG
SOURCE GeneReport for Unigene cluster: Hs.131956
Expression variation in blood from EXPOLDB for HIST1H1B |
Orthologs for HIST1H1B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HIST1H1B gene from 5/7 species (see all 7
)
About this table Species with no ortholog for HIST1H1B
ENSEMBL Gene Tree for HIST1H1B | Paralogs for HIST1H1B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HIST1H1B gene
- HIST1H1E2 HIST1H1T2 HIST1H1D2 HIST1H1C2 HIST1H1A2
|
SNPs/Variants for HIST1H1B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HIST1H1B (up to first 250kb)
|
Disorders & Mutations for HIST1H1B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 142711
2 Novoseek disease relationships for HIST1H1B gene
About this table
|
Medical News for HIST1H1B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HIST1H1B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/141 PubMed articles for HIST1H1B gene (see all 141
):- Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PubMed id 9031620)1, 2, 3, 4 Albig W....Doenecke D. (1997)
- The human and mouse replication-dependent histone genes. (PubMed id 12408966)2, 3, 4 Marzluff W.F....Maltais L.J. (2002)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)3, 4 Mungall A.J.... Beck S. (2003)
- Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)2, 3 Albig W....Doenecke D. (1997)
- Human spleen histone H1. Isolation and amino acid sequences of three minor variants, H1a, H1c, and H1d. (PubMed id 2613692)3, 4 Ohe Y.... Iwai K. (1989)
- Histone H1 phosphorylation occurs site-specifically during interphase and mitosis: identification of a novel phosphorylation site on histone H1. (PubMed id 16377619)1, 3 Sarg B....Lindner H.H. (2006)
- M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3. (PubMed id 19136008)1, 3 Happel N....Doenecke D. (2009)
- Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry. (PubMed id 15595731)1, 3 Garcia B.A....Hunt D.F. (2004)
|
Search for HIST1H1B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HIST1H1B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HIST1H1B
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIST1H1B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HIST1H1B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HIST1H1B:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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