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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIST1H1B Gene

protein-coding   GIFtS: 62
GCID: GC06M027835

Histone Cluster 1, H1b

(Previous names: H1 histone family, member 5, histone 1, H1b)
(Previous symbol: H1F5)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histone Cluster 1, H1b1 2     Histone H1s-32 3
H1F51 2 3 5     H12
H1 Histone Family, Member 51 2     H1.52
Histone 1, H1b1 2     H1B2
Histone H1a2 3     H1s-32
Histone H1b2 3     Histone H1.52

External Ids:    HGNC: 47191   Entrez Gene: 30092   Ensembl: ENSG000001843577   OMIM: 1427115   UniProtKB: P164013   

Export aliases for HIST1H1B gene to outside databases

Previous GC identifers: GC06M027893 GC06M027942 GC06M027644


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H1B Gene:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes.
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster
on chromosome 6p22-p21.3. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H1B Gene: 
HIST1H1B (histone cluster 1, H1b) is a protein-coding gene. Diseases associated with HIST1H1B include human t-cell leukemia virus type 1, and primary hyperoxaluria, and among its related super-pathways are Granzyme-A Pathway and Apoptotic cleavage of cellular proteins. GO annotations related to this gene include DNA binding. An important paralog of this gene is HIST1H1T.

UniProtKB/Swiss-Prot: H15_HUMAN, P16401
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
nucleosome spacing and DNA methylation (By similarity)

Gene Wiki entry for HIST1H1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIST1H1B gene promoter:
         Egr-3   E2F-3a   E2F-4   E2F-5   Tal-1   Brachyury   E2F-2   E47   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H1B promoter sequence
   Search SABiosciences Chromatin IP Primers for HIST1H1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.1   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p22.1

HIST1H1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M027835:  view genomic region     (about GC identifiers)

Start:
27,834,570 bp from pter      End:
27,835,359 bp from pter
Size:
790 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: H15_HUMAN, P16401 (See protein sequence)
Recommended Name: Histone H1.5  
Size: 226 amino acids; 22580 Da
Subcellular location: Nucleus. Chromosome. Note=According to PubMed:15911621 more commonly found in
heterochromatin. According to PubMed:10997781 associates with actively transcribed chromatin and not
heterochromatin
2 PDB 3D structures from and Proteopedia for HIST1H1B:
2FE2 (3D)        2RHI (3D)    
Secondary accessions: Q14529 Q3MJ42

Explore the universe of human proteins at neXtProt for HIST1H1B: NX_P16401

Explore proteomics data for HIST1H1B at MOPED 

Post-translational modifications:

  • UniProtKB: H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late
    G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity). Phosphorylated at Thr-11 by
    GSK3B during mitosis in prometaphase and dephosphorylated in telophase
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16401

  • HIST1H1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIST1H1B Protein Expression
    REFSEQ proteins: NP_005313.1  
    ENSEMBL proteins: 
     ENSP00000330074  
    Reactome Protein details: P16401
    Human Recombinant Protein Products for HIST1H1B: 
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    Cloud-Clone Corp. Proteins for HIST1H1B 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome NAS--
    GO:0000790nuclear chromatin IDA19882353
    GO:0005634nucleus ----

    HIST1H1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR005819 Histone_H5
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5

    Graphical View of Domain Structure for InterPro Entry P16401

    ProtoNet protein and cluster: P16401

    1 Blocks protein domain: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H15_HUMAN, P16401
    Domain: The C-terminal domain is required for high-affinity binding to chromatin (By similarity)
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    HIST1H1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H15_HUMAN, P16401
    Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
    the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
    structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
    nucleosome spacing and DNA methylation (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS--
         
    HIST1H1B for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HIST1H1B:
     Increased circadian rhythm amp  Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIST1H1B About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor0.32
    Apoptosis induced DNA fragmentation0.32
    Granzyme-A Pathway0.32
    2Apoptotic cleavage of cellular proteins
    Apoptotic execution phase0.73
    3Activation of cAMP-Dependent PKA
    PKA Signaling0.56
    4Activation of the pre-replicative complex
    Cell cycle Start of DNA replication in early S phase0.54
    5Cell cycle Chromosome condensation in prometaphase
    Cell cycle Chromosome condensation in prometaphase1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for HIST1H1B
        Histone modification
    Cell cycle Start of DNA replication in early S phase
    Cell cycle Chromosome condensation in prometaphase

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H1B
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1B
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase

    4        Reactome Pathways for HIST1H1B
        Activation of DNA fragmentation factor
    Apoptosis induced DNA fragmentation
    Apoptotic execution phase
    Apoptosis



    HIST1H1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIST1H1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/49 Interacting proteins for HIST1H1B (P164012, 3 ENSP000003300744) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EHMT2Q96KQ73, ENSP000003646874I2D: score=1 STRING: ENSP00000364687
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000227333Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly NAS--

    HIST1H1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIST1H1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIST1H1B (H15)

    4 Novoseek inferred chemical compound relationships for HIST1H1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 13.9 1 11724296 (1)
    nacl 12.2 7 1314829 (2), 17498293 (2), 2268409 (1)
    calcium 4.77 5 9109385 (2), 7626064 (1)
    atp 0 5 9109385 (2), 1945884 (1), 1426271 (1)

    Search CenterWatch for drugs/clinical trials and news about HIST1H1B / H15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIST1H1B gene: 
    NM_005322.2  

    Unigene Cluster for HIST1H1B:

    Histone cluster 1, H1b
    Hs.131956  [show with all ESTs]
    Unigene Representative Sequence: BG292093
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000331442(uc003njx.3)

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    Additional mRNA sequence: 

    BC069101.1 BC101581.1 BC101583.1 

    1 DOTS entry:

    DT.95174953 

    5 AceView cDNA sequences:

    NM_005322 BC069101 BX281309 BG292093 AA702996 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIST1H1B expression in normal human tissues (normalized intensities)      HIST1H1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCGGAAACCG
    HIST1H1B Expression
    About this image


    HIST1H1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Ventricular Zone
     
     Brain (Nervous System)
             Hypothalamus

    See HIST1H1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIST1H1B

    SOURCE GeneReport for Unigene cluster: Hs.131956

    UniProtKB/Swiss-Prot: H15_HUMAN, P16401
    Tissue specificity: Ubiquitous. Expressed in the majority of the cell lines tested and in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HIST1H1B gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h1b1 , 5 histone cluster 1, H1b1, 5 79.82(n)1
    91.93(a)1
      13 (7.97 cM)5
    567021  NM_020034.11  NP_064418.11 
     217798835 
    chicken
    (Gallus gallus)
    Aves LOC4278821 histone H1 71.91(n)
    77.78(a)
      427882  XM_425456.3  XP_425456.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    85(a)
    61(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343400.1(426161-426382)
    1(257466593-257467324)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83342 Xenopus laevis transcribed sequence with weak similarity more 75.24(n)    48059871 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5623071 uncharacterized LOC562307 69.54(n)
    75.13(a)
      562307  XM_703105.1  XP_708197.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta His1:CG338551 CG33855-PA 48.48(n)
    45(a)
      3771991  NM_001032198.1  NP_001027369.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HHO11 Hho1p 47.49(n)
    39.73(a)
      855976   NP_015198.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G067601 histone H1.1 47.71(n)
    40.76(a)
      837187  NM_100553.2  NP_172161.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07990001 hypothetical protein 53.01(n)
    48.78(a)
      4334439  NM_001058108.1  NP_001051573.1 


    ENSEMBL Gene Tree for HIST1H1B (if available)
    TreeFam Gene Tree for HIST1H1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIST1H1B gene
    HIST1H1T2  HIST1H1E2  H1F02  HIST1H1D2  HIST1H1C2  HIST1H1A2  
    7 SIMAP similar genes for HIST1H1B using alignment to 1 protein entry:     H15_HUMAN:
    HIST1H1E    HIST1H1C    HIST1H1D    HIST1H1A    HIST1H1T    H1F0
    H1FX

    HIST1H1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/140 SNPs in HIST1H1B are shown (see all 140)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362044
    A colorectal cancer sample4--see VAR_0362042 G D mis40--------
    rs131997721,2
    C,F,H--27834085(+) AAAAAA/GATAAT 1 -- ds50019Minor allele frequency- G:0.04NS EA NA 924
    rs1819698451,2
    --27834104(+) GAATGA/GCACGG 1 -- ds50010--------
    rs1422085251,2
    C--27834107(+) TGACAC/TGGTCA 1 -- ds50010--------
    rs1999272471,2
    --27834122(+) AAATT-/GGCATG 1 -- ds50010--------
    rs2012651121,2
    C--27834124(+) ATTGGA/CATGTA 1 -- ds50010--------
    rs131999061,2
    C,F,H--27834139(+) AGACCC/GCATCT 1 -- ds50019Minor allele frequency- G:0.06NS EA NA 726
    rs1507837511,2
    C--27834177(+) CGTTGA/GTAGCA 1 -- ds50010--------
    rs728473611,2
    C,F--27834216(+) ACGCCG/TAAGTA 1 -- ds50011Minor allele frequency- T:0.07NA 120
    rs2009461,2
    C,F,H--27834245(+) TAAACG/ACGGAA 1 -- ds50019Minor allele frequency- A:0.06MN NS EA NA 1206

    HapMap Linkage Disequilibrium report for HIST1H1B (27834570 - 27835359 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HIST1H1B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883512CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142711    OMIM disorders: --

    17 diseases for HIST1H1B:    About MalaCards
    human t-cell leukemia virus type 1    primary hyperoxaluria    ataxia telangiectasia    measles
    ataxia    lupus erythematosus    t-cell leukemia    retinoblastoma
    systemic lupus erythematosus    alzheimer's disease    melanoma    arthritis
    prostate cancer    leukemia    prostatitis    breast cancer
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HIST1H1B:
    Measles

    HIST1H1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for HIST1H1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 22.9 1 10373485 (1)
    lupus erythematosus systemic 10.3 1 12475000 (1)

    Genetic Association Database (GAD): HIST1H1B
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1B (1 document)

    Export disorders for HIST1H1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIST1H1B gene, integrated from 9 sources (see all 212):
    (articles sorted by number of sources associating them with HIST1H1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the H1.5 gene completes the set of human H1 subtype genes. (PubMed id 9031620)1, 2, 3, 9 Albig W.... Doenecke D. (1997)
    2. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F....Maltais L.J. (2002)
    3. M phase-specific phosphorylation of histone H1.5 at threonine 10 by GSK-3. (PubMed id 19136008)1, 2, 9 Happel N....Doenecke D. (2009)
    4. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    8. Distribution of somatic H1 subtypes is non-random on a ctive vs. inactive chromatin II: distribution in human adult fibroblasts. (PubMed id 11746507)1, 2 Parseghian M.H....Hamkalo B.A. (2001)
    9. The distribution of somatic H1 subtypes is non-random on active vs. inactive chromatin: distribution in human fetal fibroblasts. (PubMed id 10997781)1, 2 Parseghian M.H....Hamkalo B.A. (2000)
    10. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 3 Albig W.... Doenecke D. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3009 HGNC: 4719 AceView: HIST1H1B Ensembl:ENSG00000184357 euGenes: HUgn3009
    ECgene: HIST1H1B H-InvDB: HIST1H1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIST1H1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIST1H1B gene:
    Search GeneIP for patents involving HIST1H1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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