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HIST1H1A Gene

protein-coding   GIFtS: 61
GCID: GC06M026017

Histone Cluster 1, H1a

(Previous names: H1 histone family, member 1, histone 1, H1a)
(Previous symbol: H1F1)
  See HIST1H1A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone Cluster 1, H1a1 2     H1.12
H1F11 2 3 5     H1A2
H1 Histone Family, Member 11 2     HIST12
Histone 1, H1a1 2     Histone H1.12
Histone H1a2 3     

External Ids:    HGNC: 47151   Entrez Gene: 30242   Ensembl: ENSG000001246107   OMIM: 1427095   UniProtKB: Q025393   

Export aliases for HIST1H1A gene to outside databases

Previous GC identifers: GC06M026074 GC06M026125 GC06M025960


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIST1H1A Gene:
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes.
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which
approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts
with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.
This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA
tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster
on chromosome 6. (provided by RefSeq, Jul 2008)

GeneCards Summary for HIST1H1A Gene:
HIST1H1A (histone cluster 1, H1a) is a protein-coding gene. Diseases associated with HIST1H1A include paratyphoid fever. An important paralog of this gene is HIST1H1T.

UniProtKB/Swiss-Prot: H11_HUMAN, Q02539
Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
nucleosome spacing and DNA methylation (By similarity)

Gene Wiki entry for HIST1H1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIST1H1A gene promoter:
         NF-1/L   NF-1   Pax-5   CBF-C   Egr-4   CREB   CBF-B   deltaCREB   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIST1H1A promoter sequence
   Search Chromatin IP Primers for HIST1H1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIST1H1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.2   HGNC cytogenetic band: 6p22.1

HIST1H1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M026017:  view genomic region     (about GC identifiers)

Start:
26,017,260 bp from pter      End:
26,018,040 bp from pter
Size:
781 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: H11_HUMAN, Q02539 (See protein sequence)
Recommended Name: Histone H1.1  
Size: 215 amino acids; 21842 Da
Subunit: Interacts with DFFB
Secondary accessions: Q3MJ34

Explore the universe of human proteins at neXtProt for HIST1H1A: NX_Q02539

Explore proteomics data for HIST1H1A at MOPED

Post-translational modifications: 

  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late
    G2 phase and M phase, and being dephosphorylated sharply thereafter (By similarity)1
  • Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its
    displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell
    maintenance (By similarity)1
  • Ubiquitination2 at Lys67, Lys78, Lys93, Lys100, Lys109
  • Modification sites at PhosphoSitePlus

  • See HIST1H1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005316.1  
    ENSEMBL proteins: 
     ENSP00000244573  
    Reactome Protein details: Q02539

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HIST: Histones / Replication-dependent

    3 InterPro protein domains:
     IPR005819 Histone_H5
     IPR011991 WHTH_DNA-bd_dom
     IPR005818 Histone_H1/H5_H15

    Graphical View of Domain Structure for InterPro Entry Q02539

    ProtoNet protein and cluster: Q02539

    1 Blocks protein domain: IPB005818 Histone H1/H5

    UniProtKB/Swiss-Prot: H11_HUMAN, Q02539
    Domain: The C-terminal domain is required for high-affinity binding to chromatin
    Similarity: Belongs to the histone H1/H5 family
    Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain


    Find genes that share domains with HIST1H1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: H11_HUMAN, Q02539
    Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as
    the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order
    structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling,
    nucleosome spacing and DNA methylation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI19895577
         
    Find genes that share ontologies with HIST1H1A           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hist1h1a):
     normal  reproductive system 

    Find genes that share phenotypes with HIST1H1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hist1h1atm1Drab for HIST1H1A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIST1H1A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIST1H1A

    miRNA
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    miRTarBase miRNAs that target HIST1H1A:
    hsa-mir-30a-5p (MIRT028620), hsa-mir-34a-5p (MIRT025541), hsa-mir-320a (MIRT044419)

    Block miRNA regulation of human, mouse, rat HIST1H1A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate HIST1H1A:
    hsa-miR-1276
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIST1H1A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    H11_HUMAN, Q02539: Nucleus. Chromosome. Note=Mainly localizes in euchromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000786nucleosome IEA--
    GO:0000790nuclear chromatin IDA19882353
    GO:0005634nucleus ----

    Find genes that share ontologies with HIST1H1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIST1H1A About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of DNA fragmentation factor
    Activation of DNA fragmentation factor0.32
    Apoptosis induced DNA fragmentation0.00
    Granzyme-A Pathway0.32
    2Packaging Of Telomere Ends
    DNA Damage/Telomere Stress Induced Senescence0.65
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)0.00
    Histone modification0.31
    3Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    4Apoptotic cleavage of cellular proteins
    Apoptotic execution phase0.74
    5Activation of cAMP-Dependent PKA
    PKA Signaling0.56


    Find genes that share SuperPaths with HIST1H1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIST1H1A
        PKA Signaling
    Granzyme-A Pathway

    2 GeneGo (Thomson Reuters) Pathways for HIST1H1A
        Cell cycle Chromosome condensation in prometaphase
    Cell cycle Start of DNA replication in early S phase


    2 Reactome Pathways for HIST1H1A
        Activation of DNA fragmentation factor
    Formation of Senescence-Associated Heterochromatin Foci (SAHF)


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIST1H1A
    Interactions:

        Search GeneGlobe Interaction Network for HIST1H1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIST1H1A (Q025391, 2, 3 ENSP000002445734) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADPRHP549222, 3, ENSP000003494964MINT-7288424 I2D: score=1 STRING: ENSP00000349496
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    CDK7P506133, ENSP000002564434I2D: score=1 STRING: ENSP00000256443
    CTCFLQ8NI513, ENSP000002439144I2D: score=1 STRING: ENSP00000243914
    DOT1LQ8TEK33, ENSP000003816574I2D: score=1 STRING: ENSP00000381657
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006334nucleosome assembly IEA--
    GO:0007283spermatogenesis IEA--

    Find genes that share ontologies with HIST1H1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIST1H1A (H11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIST1H1A gene: 
    NM_005325.3  

    Unigene Cluster for HIST1H1A:

    Histone cluster 1, H1a
    Hs.150206  [show with all ESTs]
    Unigene Representative Sequence: BC112140
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000244573(uc003nfo.3)
    miRNA
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    hsa-miR-1276
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      QuantiTect SYBR Green Assays in human, mouse, rat HIST1H1A
      QuantiFast Probe-based Assays in human, mouse, rat HIST1H1A

    Additional mRNA sequence: 

    BC069492.1 BC101593.1 BC112140.1 

    1 DOTS entry:

    DT.70100850 

    4 AceView cDNA sequences:

    NM_005325 AI283277 AI283902 BC069492 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIST1H1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HIST1H1A Expression
    About this image


    HIST1H1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     NULL (Uncategorized)
             Mesenchymal Progenitor Cells - Passage 2
    HIST1H1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIST1H1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150206
        Custom PCR Arrays for HIST1H1A
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIST1H1A gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hist1h1a5 histone cluster 1, H1a   --   13 (9.91 cM) 23763717 
    chicken
    (Gallus gallus)
    Aves HIST1H111L1 histone cluster 1, H1.11L (similar to human histone more 73.75(n)
    80(a)
      427892  NM_001040643.1  NP_001035733.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    89(a)
    59(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    GL343400.1(426161-426382)
    GL343400.1(352714-353376)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1630616
    zgc:1630616
    (see all 15)
    zgc:163061
    (see all 15)
    64(a)
    63(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    7(76848733-76849489) ENSDARG00000075538
    7(76823085-76823497) ENSDARG00000076766


    ENSEMBL Gene Tree for HIST1H1A (if available)
    TreeFam Gene Tree for HIST1H1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIST1H1A gene
    HIST1H1T2  HIST1H1E2  H1F02  HIST1H1D2  HIST1H1B2  HIST1H1C2  
    7 SIMAP similar genes for HIST1H1A using alignment to 1 protein entry:     H11_HUMAN:
    HIST1H1E    HIST1H1B    HIST1H1C    HIST1H1D    HIST1H1T    H1F0
    H1FX

    Find genes that share paralogs with HIST1H1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIST1H1A (see all 128)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474207011,2
    C--26016793(+) TTCCC-/AAAGGA 1 -- ds50010--------
    rs797578401,2
    C,F--26016847(+) CCATAT/CATTTT 1 -- ds50011Minor allele frequency- C:0.05WA 118
    rs1499751481,2
    --26016921(+) TTGACA/CCCAAA 1 -- ds50010--------
    rs1152358421,2
    --26016928(+) CAAAAC/TGCAAT 1 -- ds50010--------
    rs1919920541,2
    --26016939(+) ATCCCC/TACTTT 1 -- ds50010--------
    rs1472248161,2
    C--26017030(+) GTCGTG/TAGACG 1 -- ds50010--------
    rs1405623861,2
    --26017076(+) AAACTA/CGATTT 1 -- ds50010--------
    rs728346251,2
    C--26017141(+) TCTTAC/GTAGAT 1 -- ds50010--------
    rs22372311,2
    C,F,O,A,H--26017171(-) GGAGAG/ATCGAT 1 -- ds500135Minor allele frequency- A:0.33EA NA NS WA 4784
    rs1478350151,2
    --26017214(+) ATTTGC/TTTGGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HIST1H1A (26017260 - 26018040 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIST1H1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509122CNV Insertion20534489
    nsv428137CNV Loss18775914

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142709    OMIM disorders: --

    1 disease for HIST1H1A:    
    About MalaCards
    paratyphoid fever

    2 diseases from the University of Copenhagen DISEASES database for HIST1H1A:
    Measles     Paratyphoid fever

    Find genes that share disorders with HIST1H1A           About GenesLikeMe

    Genetic Association Database (GAD): HIST1H1A
    Human Genome Epidemiology (HuGE) Navigator: HIST1H1A (1 document)

    Export disorders for HIST1H1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIST1H1A gene, integrated from 10 sources (see all 124):
    (articles sorted by number of sources associating them with HIST1H1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse replication-dependent histone genes. (PubMed id 12408966)1, 2, 3 Marzluff W.F.... Maltais L.J. (Genomics 2002)
    2. Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PubMed id 2759094)1, 2, 3 Eick S.... Doenecke D. (Eur. J. Cell Biol. 1989)
    3. The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. (PubMed id 14985337)1, 2, 9 Hendzel M.J.... Th'ng J.P. (J. Biol. Chem. 2004)
    4. Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. (PubMed id 19882353)1, 2 Ninios Y.P.... Sourlingas T.G. (Apoptosis 2010)
    5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences. (PubMed id 8003976)1, 2 Parseghian M.H.... Hamkalo B.A. (Protein Sci. 1994)
    8. Expression and chromosomal mapping of the gene encoding the human histone H1.1. (PubMed id 7989039)1, 9 Burfeind P....Engel W. (Hum. Genet. 1994)
    9. Rapid exchange of histone H1.1 on chromatin in living human cells. (PubMed id 11130728)1, 9 Lever M.A....Hendzel M.J. (Nature 2000)
    10. Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)1, 9 Albig W.... Doenecke D. (Genomics 1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3024 HGNC: 4715 AceView: HIST1H1A Ensembl:ENSG00000124610 euGenes: HUgn3024
    ECgene: HIST1H1A H-InvDB: HIST1H1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIST1H1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HIST1H1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIST1H1A gene:
    Search GeneIP for patents involving HIST1H1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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