Aliases for HIST1H1A Gene
Aliases for HIST1H1A Gene
External Ids for HIST1H1A Gene
- HGNC: 4715
- Entrez Gene: 3024
- Ensembl: ENSG00000124610
- OMIM: 142709
- UniProtKB: Q02539
Previous HGNC Symbols for HIST1H1A Gene
- H1F1
Previous GeneCards Identifiers for HIST1H1A Gene
- GC06M026074
- GC06M026125
- GC06M025960
Summaries for HIST1H1A Gene
-
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
GeneCards Summary for HIST1H1A Gene
HIST1H1A (Histone Cluster 1 H1 Family Member A) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Apoptosis induced DNA fragmentation. GO annotations related to this gene include chromatin DNA binding. An important paralog of this gene is HIST1H1E.
UniProtKB/Swiss-Prot for HIST1H1A Gene
-
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1A Gene
Genomics for HIST1H1A Gene
Regulatory Elements for HIST1H1A Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G026015 | 1 | FANTOM5 ENCODE | 2.3 | +0.6 | 553 | 2.9 | TBP CTCF TAF1 CBFB CHD1 MAX YY1 GABPA EGR1 POLR2A | ENSG00000272462 HIST1H1C HIST1H2APS5 HIST1H4C BTN3A2 HMGN4 HIST1H1A GC06M026018 |
Regulatory Element Products
Genomic Location for HIST1H1A Gene
- Chromosome:
- 6
- Start:
- 26,017,032 bp from pter
- End:
- 26,017,812 bp from pter
- Size:
- 781 bases
- Orientation:
- Minus strand
Genomic View for HIST1H1A Gene
- Cytogenetic band:
-
- 6p22.2 by Ensembl
- 6p22.2 by Entrez Gene
- 6p22.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIST1H1A Gene
Proteins for HIST1H1A Gene
-
Protein details for HIST1H1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q02539-H11_HUMAN
- Recommended name:
- Histone H1.1
- Protein Accession:
- Q02539
- Q3MJ34
Protein attributes for HIST1H1A Gene
- Size:
- 215 amino acids
- Molecular mass:
- 21842 Da
- Quaternary structure:
-
- Interacts with DFFB.
Protein Expression for HIST1H1A Gene
Post-translational modifications for HIST1H1A Gene
- Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
- H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HIST1H1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for HIST1H1A
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Protein Products
-
OriGene Purified Proteins for HIST1H1A
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-
Abcam proteins for HIST1H1A
Assay Products
No data available for DME Specific Peptides for HIST1H1A Gene
Domains & Families for HIST1H1A Gene
Gene Families for HIST1H1A Gene
- HGNC:
Protein Domains for HIST1H1A Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIST1H1A Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q02539UniProtKB/Swiss-Prot:
H11_HUMAN :- The C-terminal domain is required for high-affinity binding to chromatin.
- Belongs to the histone H1/H5 family.
- Domain:
-
- The C-terminal domain is required for high-affinity binding to chromatin.
- Family:
-
- Belongs to the histone H1/H5 family.
Function for HIST1H1A Gene
Molecular function for HIST1H1A Gene
- UniProtKB/Swiss-Prot Function:
- Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 19895577 |
| GO:0008201 | heparin binding | IEA | -- |
| GO:0031490 | chromatin DNA binding | IMP | 15911621 |
Phenotypes for HIST1H1A Gene
- GenomeRNAi human phenotypes for HIST1H1A:
Animal Model Products
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miRNA for HIST1H1A Gene
- miRTarBase miRNAs that target HIST1H1A
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H1A Gene
Localization for HIST1H1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1A Gene
- Nucleus. Chromosome. Note=Mainly localizes in euchromatin.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000786 | nucleosome | IEA | -- |
| GO:0000790 | nuclear chromatin | IDA | 19882353 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
| GO:0005719 | nuclear euchromatin | IDA | 15911621 |
Pathways & Interactions for HIST1H1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis induced DNA fragmentation | ||
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
| 3 | Cellular Senescence | ||
| 4 | DNA Damage/Telomere Stress Induced Senescence | ||
| 5 | Activation of cAMP-Dependent PKA |
.56
|
|
Pathways by source for HIST1H1A Gene
1 GeneTex pathway for HIST1H1A Gene
9 Reactome pathways for HIST1H1A Gene
2 GeneGo (Thomson Reuters) pathways for HIST1H1A Gene
2 Qiagen pathways for HIST1H1A Gene
Interacting Proteins for HIST1H1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006334 | nucleosome assembly | IEA | -- |
| GO:0007283 | spermatogenesis | IEA,TAS | -- |
| GO:0048260 | positive regulation of receptor-mediated endocytosis | IEA | -- |
Transcripts for HIST1H1A Gene
mRNA/cDNA for HIST1H1A Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIST1H1A Gene
CRISPR Products
-
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-
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Expression for HIST1H1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HIST1H1A Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIST1H1A Gene
NURSA nuclear receptor signaling pathways regulating expression of HIST1H1A Gene:
HIST1H1ASOURCE GeneReport for Unigene cluster for HIST1H1A Gene:
Hs.150206Evidence on tissue expression from TISSUES for HIST1H1A Gene
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for HIST1H1A
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIST1H1A Gene
Orthologs for HIST1H1A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIST1H1A 35 |
|
OneToOne | |
| LOC471874 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | HIST1H1A 35 |
|
OneToOne | |
| LOC488258 34 |
|
||||
| mouse (Mus musculus) |
Mammalia | Hist1h1a 35 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HIST1H1A 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | HIST1H111L 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | zgc:163061 35 35 |
|
ManyToMany | |
| CU457819.3 35 |
|
ManyToMany | |||
| CABZ01086354.1 35 |
|
ManyToMany | |||
| FP325123.1 35 |
|
ManyToMany | |||
| zgc:110425 35 |
|
ManyToMany | |||
| si:ch211-113a14.12 35 |
|
ManyToMany | |||
| si:ch211-113a14.18 35 |
|
ManyToMany | |||
| si:ch211-113a14.24 35 |
|
ManyToMany | |||
| zgc:153405 35 |
|
ManyToMany | |||
| histh1l 35 |
|
ManyToMany | |||
| si:dkey-108k21.10 35 |
|
ManyToMany | |||
| si:dkey-108k21.14 35 |
|
ManyToMany | |||
| si:dkey-261m9.12 35 |
|
ManyToMany | |||
| si:dkey-108k21.21 35 |
|
ManyToMany |
- Species where no ortholog for HIST1H1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIST1H1A Gene
Variants for HIST1H1A Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000185520 | -- | 26,016,751(+) | GGGAC(C/T)GGGCT | downstream-variant-500B | |
| rs1001157548 | -- | 26,018,849(+) | AGAAT(A/T)AAAAA | upstream-variant-2KB | |
| rs1001186755 | -- | 26,017,476(+) | TAATG(C/T)CCAGC | reference, missense | |
| rs1002187606 | -- | 26,018,159(+) | GGTCC(A/G)TTGCC | upstream-variant-2KB | |
| rs1004266136 | -- | 26,017,498(+) | GTTGT(C/T)CTTCT | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5926n100 | CNV | gain | 25217958 |
| nsv1023453 | CNV | gain | 25217958 |
| nsv428137 | CNV | loss | 18775914 |
| nsv509122 | CNV | insertion | 20534489 |
Relevant External Links for HIST1H1A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIST1H1A
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1A Gene
Disorders for HIST1H1A Gene
Relevant External Links for HIST1H1A
No disorders were found for HIST1H1A Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1A Gene
Publications for HIST1H1A Gene
- The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. (PMID: 14985337) Hendzel M.J. … Th'ng J.P. (J. Biol. Chem. 2004) 3 4 22 64
- The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 64
- Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PMID: 2759094) Eick S. … Doenecke D. (Eur. J. Cell Biol. 1989) 2 3 4 64
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
- Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells. (PMID: 19882353) Ninios Y.P. … Sourlingas T.G. (Apoptosis 2010) 3 4 64
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Sources for HIST1H1A Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (18) KEGG
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (86) GenomeRNAi
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- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




