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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HIST1H1A Gene

protein-coding GIFtS: 55
GCID: GC06M026017

histone cluster 1, H1a

(Previous names: H1 histone family, member 1, histone 1, H1a )
(Previous symbol: H1F1)

Explore 8 diseases affiliated with
HIST1H1A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histone Cluster 1, H1a¹ ²		Histone H1a² ³
H1F1¹ ² ³ ⁵		H1a¹
H1.1¹ ²		H1A²
H1 Histone Family, Member 1¹ ²		HIST1²
Histone 1, H1a¹ ²		Histone H1.1²

External Ids:	HGNC: 4715¹	Entrez Gene: 3024²	Ensembl: ENSG00000124610⁷	OMIM: 142709⁵	UniProtKB: Q02539³

Export aliases for HIST1H1A gene to outside databases

Previous GC identifers: GC06M026074 GC06M026125 GC06M025960

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIST1H1A:

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two

molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp

of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between

nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and

encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a

palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: H11_HUMAN, Q02539

Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the

chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured

fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and

DNA methylation (By similarity)

Gene Wiki entry for HIST1H1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HIST1H1A gene promoter:
NF-1/L NF-1 Pax-5 CBF-C Egr-4 CREB CBF-B deltaCREB Pax-4a CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HIST1H1A promoter sequence

Search SABiosciences Chromatin IP Primers for HIST1H1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIST1H1A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.2 HGNC cytogenetic band: 6p22.1

HIST1H1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIST1H1A gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M026017: view genomic region (about GC identifiers)

Start:	26,017,260 bp from pter	End:	26,018,040 bp from pter
Size:	781 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: H11_HUMAN, Q02539 (See protein sequence)

Recommended Name: Histone H1.1

Size: 215 amino acids; 21842 Da

Subunit: Interacts with DFFB

Subcellular location: Nucleus. Chromosome. Note=Mainly localizes in euchromatin

Secondary accessions: Q3MJ34

Explore the universe of human proteins at neXtProt for HIST1H1A: NX_Q02539

Post-translational modifications:

H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2

phase and M phase, and being dephosphorylated sharply thereafter (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q02539

HIST1H1A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005316.1

ENSEMBL proteins:

ENSP00000244573

Reactome Protein details: Q02539
Human Recombinant Protein Products for HIST1H1A:

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	Uscn Proteins for HIST1H1A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000786	nucleosome	IEA	--
GO:0000790	nuclear chromatin	IDA	19882353

HIST1H1A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for HIST1H1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HIST1H1A for domains About GeneDecksing

3 InterPro domains/families:

IPR005819 Histone_H5

IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom

IPR005818 Histone_H1/H5

Graphical View of Domain Structure for InterPro Entry Q02539

ProtoNet protein and cluster: Q02539

1 Blocks protein family: IPB005818 Histone H1/H5

UniProtKB/Swiss-Prot: H11_HUMAN, Q02539

Domain: The C-terminal domain is required for high-affinity binding to chromatin

Similarity: Belongs to the histone H1/H5 family

Similarity: Contains 1 H15 (linker histone H1/H5 globular) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: H11_HUMAN, Q02539

Function: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the

chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured

fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and

DNA methylation (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--

HIST1H1A for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hist1h1a):

normal

reproductive system

HIST1H1A for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Hist1h1a^tm1Drab for HIST1H1A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HIST1H1A

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H1A
		1 QIAGEN miScript miRNA Assays for microRNA that regulate HIST1H1A:
		hsa-miR-1276
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of DNA fragmentation factor

	Activation of DNA fragmentation factor	1.00			Granzyme-A Pathway	0.32
	Apoptosis induced DNA fragmentation	1.00

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Cell cycle Chromosome condensation in prometaphase

Cell cycle Chromosome condensation in prometaphase

1.00

Cell cycle_Chromosome condensation in prometaphase

1.00

Apoptotic cleavage of cellular proteins

Apoptotic execution phase

0.73

Activation of cAMP-Dependent PKA

PKA Signaling

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for HIST1H1A

	Histone modification
	Cell cycle Start of DNA replication in early S phase
	Cell cycle Chromosome condensation in prometaphase

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for HIST1H1A

	PKA Signaling
	Granzyme-A Pathway

2 GeneGo (Thomson Reuters) Pathways for HIST1H1A

	Cell cycle Chromosome condensation in prometaphase
	Cell cycle Start of DNA replication in early S phase

4 Reactome Pathways for HIST1H1A

	Activation of DNA fragmentation factor
	Apoptosis induced DNA fragmentation
	Apoptotic execution phase
	Apoptosis

HIST1H1A for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HIST1H1A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/48 Interacting proteins for HIST1H1A (Q02539^{2, 3} ENSP00000244573⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADPRH	P54922²^,³, ENSP00000349496⁴	MINT-7288424 I2D: score=1 STRING: ENSP00000349496
CDK2	P24941³, ENSP00000266970⁴	I2D: score=1 STRING: ENSP00000266970
CDK7	P50613³, ENSP00000256443⁴	I2D: score=1 STRING: ENSP00000256443
CTCFL	Q8NI51³, ENSP00000243914⁴	I2D: score=1 STRING: ENSP00000243914
DOT1L	Q8TEK3³, ENSP00000381657⁴	I2D: score=1 STRING: ENSP00000381657

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006334	nucleosome assembly	IEA	--
GO:0007283	spermatogenesis	IEA	--

HIST1H1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HIST1H1A
Search CenterWatch for drugs/clinical trials and news about HIST1H1A / H11

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HIST1H1A gene:

NM_005325.3

Unigene Cluster for HIST1H1A:

Histone cluster 1, H1a

Hs.150206 [show with all ESTs]

Unigene Representative Sequence: BC112140

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000244573(uc003nfo.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIST1H1A
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		hsa-miR-1276
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIST1H1A (see all 7) OriGene shRNA RFP: HIST1H1A OriGene siRNA: HIST1H1A
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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIST1H1A OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIST1H1A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIST1H1A

Additional cDNA sequence:

BC069492.1 BC101593.1 BC112140.1

1 DOTS entry:

DT.70100850

4 AceView cDNA sequences:

BC069492 AI283902 NM_005325 AI283277

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HIST1H1A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

HIST1H1A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mesenchymal Progenitor Cells - Passage 2 (Differentiation of ...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HIST1H1A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIST1H1A

SOURCE GeneReport for Unigene cluster: Hs.150206

SABiosciences Custom PCR Arrays for HIST1H1A

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for HIST1H1A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HIST1H1A gene from 7/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NME1_CHICK⁶ F1NPJ2_CHICK⁶ (see all 5)	Uncharacterized protein (see all 5)	66(a) 65(a) (see all 5)	many ↔ many many ↔ many (see all 5)	1(50050557-50051216) 1(49946004-49946660)
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 4)	--	89(a) 57(a) (see all 4)	many ↔ many many ↔ many (see all 4)	GL343400.1(426161-426382) GL343279.1(541498-542142)
zebrafish (Danio rerio)	Actinopterygii	zgc:163061⁶ zgc:163061⁶ (see all 15)	zgc:163061 (see all 15)	62(a) 62(a) (see all 15)	many ↔ many many ↔ many (see all 15)	7(76823085-76823497) 7(76848733-76849489)
fruit fly (Drosophila melanogaster)	Insecta	His1:CG33864⁶ His1:CG33858⁶ (see all 23)	His1:CG33858 (see all 23)	26(a) 26(a) (see all 23)	many ↔ many many ↔ many (see all 23)	2L(21536471-21537368) 2L(21526584-21527481)
worm (Caenorhabditis elegans)	Secernentea	hil-2¹	Protein HIL-2	46.07(n) 44.38(a)		177390 NM_171356.4 NP_741417.3
thale cress (Arabidopsis thaliana)	eudicotyledons	HIS1-3⁶ AT1G06760⁶ (see all 3)	histone H1.1 (see all 3)	19(a) 14(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(7845923-7846884) 1(2076504-2077698)
rice (Oryza sativa)	Liliopsida	-- -- (see all 4)	histone H1, putative, expressed (see all 4)	19(a) 15(a) (see all 4)	many ↔ many many ↔ many (see all 4)	4(9984198-9985211) 6(1641215-1642801)

ENSEMBL Gene Tree for HIST1H1A (if available)
TreeFam Gene Tree for HIST1H1A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HIST1H1A gene

HIST1H1T² HIST1H1D² H1F0² H1FOO² HIST1H1E² HIST1H1C² HIST1H1B² H1FX²

7 SIMAP similar genes for HIST1H1A using alignment to 1 protein entry: H11_HUMAN:

HIST1H1E HIST1H1B HIST1H1C HIST1H1D HIST1H1T H1F0

H1FX

HIST1H1A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147420701^1,2	C	--	26016793(+)	`TTCCC-/AAAGGA`	1	--	ds500¹		0	--	--	--	--
rs79757840^1,2	C,F	--	26016847(+)	`CCATAT/CATTTT`	1	--	ds500¹		1		WA	118
rs149975148^1,2		--	26016921(+)	`TTGACA/CCCAAA`	1	--	ds500¹		0	--	--	--	--
rs115235842^1,2		--	26016928(+)	`CAAAAC/TGCAAT`	1	--	ds500¹		0	--	--	--	--
rs191992054^1,2		--	26016939(+)	`ATCCCC/TACTTT`	1	--	ds500¹		0	--	--	--	--
rs147224816^1,2		--	26017030(+)	`GTCGTG/TAGACG`	1	--	ds500¹		0	--	--	--	--
rs140562386^1,2		--	26017076(+)	`AAACTA/CGATTT`	1	--	ds500¹		0	--	--	--	--
rs72834625^1,2	C	--	26017141(+)	`TCTTAC/GTAGAT`	1	--	ds500¹		0	--	--	--	--
rs2237231^1,2	C,F,O,A,H	--	26017171(-)	`GGAGAG/ATCGAT`	1	--	ds500¹		35		EA NA NS WA	4784
rs147835015^1,2		--	26017214(+)	`ATTTGC/TTTGGG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HIST1H1A (26017260 - 26018040 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HIST1H1A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HIST1H1A for disorders           About GeneDecksing

OMIM gene information: 142709    OMIM disorders: --

8 diseases for HIST1H1A:    About MalaCards

paratyphoid fever hemochromatosis measles breast cancer

embryonal carcinoma prostatitis carcinoma neuronitis

1 disease from the University of Copenhagen DISEASES database for HIST1H1A:

Measles

Human Genome Epidemiology (HuGE) Navigator: HIST1H1A (1 document)

Export disorders for HIST1H1A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HIST1H1A gene, integrated from 9 sources (see all 102):
(articles sorted by number of sources associating them with HIST1H1A)

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The human and mouse replication-dependent histone genes. (PubMed id 12408966)^{1, 2, 3} Marzluff W.F....Maltais L.J. (2002)
Human H1 histones: conserved and varied sequence elements in two H1 subtype genes. (PubMed id 2759094)^{1, 2, 3} Eick S.... Doenecke D. (1989)
The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. (PubMed id 14985337)^{1, 2, 9} Hendzel M.J....Th'ng J.P. (2004)
Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leuke mic cells. (PubMed id 19882353)^{1, 2} Ninios Y.P....Sourlingas T.G. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A proposal for a coherent mammalian histone H1 nomenclature correlated with amino acid sequences. (PubMed id 8003976)^{1, 2} Parseghian M.H.... Hamkalo B.A. (1994)
Expression and chromosomal mapping of the gene encoding the human histone H1.1. (PubMed id 7989039)^{1, 9} Burfeind P....Engel W. (1994)
Rapid exchange of histone H1.1 on chromatin in living human cells. (PubMed id 11130728)^{1, 9} Lever M.A....Hendzel M.J. (2000)
Human histone gene organization: nonregular arrangement within a large cluster. (PubMed id 9119399)^{1, 9} Albig W.... Doenecke D. (1997)
A p27Kip1 mutant that does not inhibit CDK activity pr omotes centrosome amplification and micronucleation. (PubMed id 22158041)¹ Sharma S.S....Pledger W.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3024	HGNC: 4715	AceView: HIST1H1A	Ensembl:ENSG00000124610	euGenes: HUgn3024
ECgene: HIST1H1A	H-InvDB: HIST1H1A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HIST1H1A	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for HIST1H1A	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for HIST1H1A gene
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Patent Information for HIST1H1A gene:
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