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Aliases for HIST1H1A Gene

Aliases for HIST1H1A Gene

  • Histone Cluster 1, H1a 2 3 5
  • H1 Histone Family, Member 1 2 3
  • Histone 1, H1a 2 3
  • Histone H1a 3 4
  • H1F1 3 4
  • HIST1 3
  • H1.1 3
  • H1A 3

External Ids for HIST1H1A Gene

Previous HGNC Symbols for HIST1H1A Gene

  • H1F1

Previous GeneCards Identifiers for HIST1H1A Gene

  • GC06M026074
  • GC06M026125
  • GC06M025960

Summaries for HIST1H1A Gene

Entrez Gene Summary for HIST1H1A Gene

  • Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

GeneCards Summary for HIST1H1A Gene

HIST1H1A (Histone Cluster 1, H1a) is a Protein Coding gene. Among its related pathways are Cellular Senescence and Packaging Of Telomere Ends. GO annotations related to this gene include chromatin DNA binding. An important paralog of this gene is HIST1H1D.

UniProtKB/Swiss-Prot for HIST1H1A Gene

  • Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Wiki entry for HIST1H1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIST1H1A Gene

Genomics for HIST1H1A Gene

Regulatory Elements for HIST1H1A Gene

Promoters for HIST1H1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIST1H1A on UCSC Golden Path with GeneCards custom track

Genomic Location for HIST1H1A Gene

Chromosome:
6
Start:
26,017,032 bp from pter
End:
26,017,812 bp from pter
Size:
781 bases
Orientation:
Minus strand

Genomic View for HIST1H1A Gene

Genes around HIST1H1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIST1H1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIST1H1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIST1H1A Gene

Proteins for HIST1H1A Gene

  • Protein details for HIST1H1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02539-H11_HUMAN
    Recommended name:
    Histone H1.1
    Protein Accession:
    Q02539
    Secondary Accessions:
    • Q3MJ34

    Protein attributes for HIST1H1A Gene

    Size:
    215 amino acids
    Molecular mass:
    21842 Da
    Quaternary structure:
    • Interacts with DFFB.

neXtProt entry for HIST1H1A Gene

Proteomics data for HIST1H1A Gene at MOPED

Post-translational modifications for HIST1H1A Gene

  • Citrullination at Arg-57 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance.
  • H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIST1H1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIST1H1A Gene

Domains & Families for HIST1H1A Gene

Gene Families for HIST1H1A Gene

Protein Domains for HIST1H1A Gene

Suggested Antigen Peptide Sequences for HIST1H1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02539

UniProtKB/Swiss-Prot:

H11_HUMAN :
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Belongs to the histone H1/H5 family.
Domain:
  • The C-terminal domain is required for high-affinity binding to chromatin.
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HIST1H1A: view

Function for HIST1H1A Gene

Molecular function for HIST1H1A Gene

UniProtKB/Swiss-Prot Function:
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).

Gene Ontology (GO) - Molecular Function for HIST1H1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031490 chromatin DNA binding IMP 15911621
genes like me logo Genes that share ontologies with HIST1H1A: view

Phenotypes for HIST1H1A Gene

genes like me logo Genes that share phenotypes with HIST1H1A: view

Animal Model Products

miRNA for HIST1H1A Gene

miRTarBase miRNAs that target HIST1H1A

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIST1H1A Gene

Localization for HIST1H1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIST1H1A Gene

Nucleus. Chromosome. Note=Mainly localizes in euchromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIST1H1A Gene COMPARTMENTS Subcellular localization image for HIST1H1A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for HIST1H1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005719 nuclear euchromatin IDA 15911621
genes like me logo Genes that share ontologies with HIST1H1A: view

Pathways & Interactions for HIST1H1A Gene

genes like me logo Genes that share pathways with HIST1H1A: view

Pathways by source for HIST1H1A Gene

SIGNOR curated interactions for HIST1H1A Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HIST1H1A Gene

None

Drugs & Compounds for HIST1H1A Gene

No Compound Related Data Available

Transcripts for HIST1H1A Gene

mRNA/cDNA for HIST1H1A Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIST1H1A Gene

Histone cluster 1, H1a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIST1H1A Gene

No ASD Table

Relevant External Links for HIST1H1A Gene

GeneLoc Exon Structure for
HIST1H1A
ECgene alternative splicing isoforms for
HIST1H1A

Expression for HIST1H1A Gene

mRNA expression in normal human tissues for HIST1H1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HIST1H1A Gene

This gene is overexpressed in Testis (x12.3) and Liver (x6.0).

Protein differential expression in normal tissues from HIPED for HIST1H1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.0), Fetal testis (10.5), and Neutrophil (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIST1H1A Gene



SOURCE GeneReport for Unigene cluster for HIST1H1A Gene Hs.150206

genes like me logo Genes that share expression patterns with HIST1H1A: view

Protein tissue co-expression partners for HIST1H1A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HIST1H1A Gene

Orthologs for HIST1H1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIST1H1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIST1H1A 35
  • 78.73 (n)
  • 81.41 (a)
HIST1H1A 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC488258 35
  • 79.17 (n)
  • 81.25 (a)
HIST1H1A 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC471874 35
  • 98.91 (n)
  • 98.6 (a)
HIST1H1A 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hist1h1a 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
chicken
(Gallus gallus)
Aves HIST1H111L 35
  • 73.75 (n)
  • 80 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 57 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01086354.1 36
  • 60 (a)
ManyToMany
CU457819.3 36
  • 62 (a)
ManyToMany
FP325123.1 36
  • 60 (a)
ManyToMany
histh1l 36
  • 58 (a)
ManyToMany
si:ch211-113a14.12 36
  • 59 (a)
ManyToMany
si:ch211-113a14.18 36
  • 59 (a)
ManyToMany
si:ch211-113a14.24 36
  • 59 (a)
ManyToMany
si:dkey-108k21.10 36
  • 58 (a)
ManyToMany
si:dkey-108k21.14 36
  • 58 (a)
ManyToMany
si:dkey-108k21.21 36
  • 54 (a)
ManyToMany
si:dkey-261m9.12 36
  • 58 (a)
ManyToMany
zgc:110425 36
  • 60 (a)
ManyToMany
zgc:153405 36
  • 59 (a)
ManyToMany
zgc:163061 36
  • 63 (a)
ManyToMany
zgc:163061 36
  • 64 (a)
ManyToMany
Species with no ortholog for HIST1H1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIST1H1A Gene

ENSEMBL:
Gene Tree for HIST1H1A (if available)
TreeFam:
Gene Tree for HIST1H1A (if available)

Paralogs for HIST1H1A Gene

Paralogs for HIST1H1A Gene

(7) SIMAP similar genes for HIST1H1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIST1H1A: view

Variants for HIST1H1A Gene

Sequence variations from dbSNP and Humsavar for HIST1H1A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs417751 - 26,017,437(-) GCAGA(C/T)AAAGG reference, missense
rs34541321 - 26,017,389(+) CGGAG(A/G/T)ACGCC reference, missense
rs16891235 - 26,017,314(+) CCTTT(C/T)TGAGC reference, missense
rs199749 -- 26,017,857(+) TGCCC(A/G)CCCCT upstream-variant-2KB
rs2237231 -- 26,016,943(-) GGAGA(A/G)TCGAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIST1H1A Gene

Variant ID Type Subtype PubMed ID
nsv428137 CNV Loss 18775914
nsv509122 CNV Insertion 20534489

Variation tolerance for HIST1H1A Gene

Residual Variation Intolerance Score: 64.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.10; 61.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIST1H1A Gene

HapMap Linkage Disequilibrium report
HIST1H1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIST1H1A Gene

Disorders for HIST1H1A Gene

Relevant External Links for HIST1H1A

Genetic Association Database (GAD)
HIST1H1A
Human Genome Epidemiology (HuGE) Navigator
HIST1H1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIST1H1A

No disorders were found for HIST1H1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIST1H1A Gene

Publications for HIST1H1A Gene

  1. The human and mouse replication-dependent histone genes. (PMID: 12408966) Marzluff W.F. … Maltais L.J. (Genomics 2002) 2 3 4 67
  2. The C-terminal domain is the primary determinant of histone H1 binding to chromatin in vivo. (PMID: 14985337) Hendzel M.J. … Th'ng J.P. (J. Biol. Chem. 2004) 3 23
  3. Rapid exchange of histone H1.1 on chromatin in living human cells. (PMID: 11130728) Lever M.A. … Hendzel M.J. (Nature 2000) 3 23
  4. Human histone gene organization: nonregular arrangement within a large cluster. (PMID: 9119399) Albig W. … Doenecke D. (Genomics 1997) 3 23
  5. Expression and chromosomal mapping of the gene encoding the human histone H1.1. (PMID: 7989039) Burfeind P. … Engel W. (Hum. Genet. 1994) 3 23

Products for HIST1H1A Gene

Sources for HIST1H1A Gene

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