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Aliases for HIRIP3 Gene

Aliases for HIRIP3 Gene

  • HIRA Interacting Protein 3 2 3 5
  • HIRA-Interacting Protein 3 2

External Ids for HIRIP3 Gene

Previous GeneCards Identifiers for HIRIP3 Gene

  • GC16P029153
  • GC16M030326
  • GC16M030002
  • GC16M030041
  • GC16M029911
  • GC16M030005
  • GC16M027665

Summaries for HIRIP3 Gene

Entrez Gene Summary for HIRIP3 Gene

  • The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for HIRIP3 Gene

HIRIP3 (HIRA Interacting Protein 3) is a Protein Coding gene. Diseases associated with HIRIP3 include Velocardiofacial Syndrome.

UniProtKB/Swiss-Prot for HIRIP3 Gene

  • May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.

Gene Wiki entry for HIRIP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIRIP3 Gene

Genomics for HIRIP3 Gene

Regulatory Elements for HIRIP3 Gene

Enhancers for HIRIP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIRIP3 on UCSC Golden Path with GeneCards custom track

Promoters for HIRIP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIRIP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HIRIP3 Gene

29,992,321 bp from pter
29,996,436 bp from pter
4,116 bases
Minus strand

Genomic View for HIRIP3 Gene

Genes around HIRIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIRIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIRIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIRIP3 Gene

Proteins for HIRIP3 Gene

  • Protein details for HIRIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HIRA-interacting protein 3
    Protein Accession:
    Secondary Accessions:
    • H3BSR3
    • O75707
    • O75708

    Protein attributes for HIRIP3 Gene

    556 amino acids
    Molecular mass:
    61957 Da
    Quaternary structure:
    • Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2.

    Alternative splice isoforms for HIRIP3 Gene


neXtProt entry for HIRIP3 Gene

Proteomics data for HIRIP3 Gene at MOPED

Post-translational modifications for HIRIP3 Gene

Other Protein References for HIRIP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIRIP3 Gene

Domains & Families for HIRIP3 Gene

Protein Domains for HIRIP3 Gene


Suggested Antigen Peptide Sequences for HIRIP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HIRIP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HIRIP3 Gene

Function for HIRIP3 Gene

Molecular function for HIRIP3 Gene

GENATLAS Biochemistry:
HIRA-interacting protein 3,widely expressed an histone (H2B,H3) binding protein,directly interacting with the WD-repeat protein HIRA
UniProtKB/Swiss-Prot Function:
May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.
genes like me logo Genes that share phenotypes with HIRIP3: view

Animal Models for HIRIP3 Gene

MGI Knock Outs for HIRIP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIRIP3 Gene

Localization for HIRIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIRIP3 Gene

Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.

Subcellular locations from

Jensen Localization Image for HIRIP3 Gene COMPARTMENTS Subcellular localization image for HIRIP3 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for HIRIP3 Gene

Pathways & Interactions for HIRIP3 Gene

SuperPathways for HIRIP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIRIP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for HIRIP3 Gene

Drugs & Compounds for HIRIP3 Gene

(1) Additional Compounds for HIRIP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Behenoyl-CoA
  • Behenoyl-Coenzyme A
genes like me logo Genes that share compounds with HIRIP3: view

Transcripts for HIRIP3 Gene

Unigene Clusters for HIRIP3 Gene

HIRA interacting protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIRIP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - - - -
SP10: -

Relevant External Links for HIRIP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIRIP3 Gene

mRNA expression in normal human tissues for HIRIP3 Gene

Protein differential expression in normal tissues from HIPED for HIRIP3 Gene

This gene is overexpressed in Cervix (38.7) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIRIP3 Gene

SOURCE GeneReport for Unigene cluster for HIRIP3 Gene Hs.567370

mRNA Expression by UniProt/SwissProt for HIRIP3 Gene

Tissue specificity: Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart.
genes like me logo Genes that share expression patterns with HIRIP3: view

Protein tissue co-expression partners for HIRIP3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HIRIP3 Gene

Orthologs for HIRIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIRIP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HIRIP3 35
  • 80.17 (n)
  • 73.61 (a)
  • 72 (a)
(Canis familiaris)
Mammalia HIRIP3 35
  • 82.44 (n)
  • 76.34 (a)
  • 70 (a)
(Mus musculus)
Mammalia Hirip3 35
  • 70.86 (n)
  • 61.71 (a)
Hirip3 16
Hirip3 36
  • 54 (a)
(Pan troglodytes)
Mammalia HIRIP3 35
  • 99.16 (n)
  • 98.92 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Hirip3 35
  • 73.83 (n)
  • 65.53 (a)
(Monodelphis domestica)
Mammalia HIRIP3 36
  • 39 (a)
(Anolis carolinensis)
Reptilia HIRIP3 36
  • 28 (a)
(Danio rerio)
Actinopterygii hirip3 36
  • 29 (a)
Species with no ortholog for HIRIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIRIP3 Gene

Gene Tree for HIRIP3 (if available)
Gene Tree for HIRIP3 (if available)

Paralogs for HIRIP3 Gene

No data available for Paralogs for HIRIP3 Gene

Variants for HIRIP3 Gene

Sequence variations from dbSNP and Humsavar for HIRIP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs11643314 - 29,993,317(+) CTCCC(A/C)TGGGG reference, missense, utr-variant-3-prime
rs35431046 - 29,993,479(-) TGTTG(C/T)GAACA reference, missense, utr-variant-3-prime
rs1135662 -- 29,993,689(+) CGCTC(C/T)TTGTG reference, synonymous-codon, missense
rs78703232 -- 29,993,669(+) CTGCC(C/G/T)GGAGG reference, synonymous-codon, missense
rs117348377 -- 29,992,794(+) GGGGT(A/G)GGCGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HIRIP3 Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294
esv997840 CNV Deletion 20482838

Variation tolerance for HIRIP3 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.94% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HIRIP3 Gene

Disorders for HIRIP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HIRIP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
velocardiofacial syndrome
  • cayler cardiofacial syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HIRIP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HIRIP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HIRIP3 Gene

Publications for HIRIP3 Gene

  1. Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. (PMID: 9710638) Lorain S. … Lipinski M. (Mol. Cell. Biol. 1998) 2 3 4 23 67
  2. HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2. (PMID: 17391060) Assrir N. … Lipinski M. (Biol. Chem. 2007) 3 23
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HIRIP3 Gene

Sources for HIRIP3 Gene