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Aliases for HIRIP3 Gene

Aliases for HIRIP3 Gene

  • HIRA Interacting Protein 3 2 3 5
  • HIRA-Interacting Protein 3 2

External Ids for HIRIP3 Gene

Previous GeneCards Identifiers for HIRIP3 Gene

  • GC16P029153
  • GC16M030326
  • GC16M030002
  • GC16M030041
  • GC16M029911
  • GC16M030005
  • GC16M027665

Summaries for HIRIP3 Gene

Entrez Gene Summary for HIRIP3 Gene

  • The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for HIRIP3 Gene

HIRIP3 (HIRA Interacting Protein 3) is a Protein Coding gene. Diseases associated with HIRIP3 include Velocardiofacial Syndrome.

UniProtKB/Swiss-Prot for HIRIP3 Gene

  • May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.

Gene Wiki entry for HIRIP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIRIP3 Gene

Genomics for HIRIP3 Gene

Regulatory Elements for HIRIP3 Gene

Enhancers for HIRIP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G029942 1.7 FANTOM5 Ensembl ENCODE 11.4 +52.5 52454 3.7 CREB3L1 ZFP64 FEZF1 ZNF263 SP3 MEF2D ZNF610 GLIS1 RCOR2 NBN ZNF785 ENSG00000260853 NPIPB13 MIR762HG BCL7C ENSG00000260114 NFATC2IP SMG1P2 INO80E ENSG00000260367
GH16G029972 1.4 Ensembl ENCODE 12.9 +20.9 20880 6.1 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 NPIPB13 ZNF785 ZNF747 BCL7C ENSG00000198106 ZNF764 INO80E ENSG00000260367 SMG1P2 ENSG00000260114
GH16G029819 1.5 FANTOM5 ENCODE dbSUPER 11.4 +173.5 173522 7.5 HDGF PKNOX1 AGO1 SIN3A ZNF48 YY1 ZNF121 GLIS2 GATA2 FOS DOC2A TMEM219 INO80E HIRIP3 C16orf92 FAM57B GDPD3 CDIPT-AS1 MVP TBX6
GH16G029961 1.2 ENCODE 12 +34.0 34049 2.5 CREB3L1 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF416 ZNF263 ZNF785 NPIPB13 BCL7C ENSG00000260853 INO80E ZNF747 ZNF764 ENSG00000260114 ENSG00000260367 SMG1P2
GH16G029828 1.2 Ensembl ENCODE 11.4 +166.4 166407 3.4 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 SP5 KAT8 MIER3 RCOR2 CDIPT-AS1 CDIPT C16orf92 FAM57B DOC2A TMEM219 HIRIP3 INO80E C16orf54 ZNF689
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIRIP3 on UCSC Golden Path with GeneCards custom track

Promoters for HIRIP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085136 436 1601 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263

Genomic Location for HIRIP3 Gene

Chromosome:
16
Start:
29,992,321 bp from pter
End:
29,996,436 bp from pter
Size:
4,116 bases
Orientation:
Minus strand

Genomic View for HIRIP3 Gene

Genes around HIRIP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIRIP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIRIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIRIP3 Gene

Proteins for HIRIP3 Gene

  • Protein details for HIRIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW71-HIRP3_HUMAN
    Recommended name:
    HIRA-interacting protein 3
    Protein Accession:
    Q9BW71
    Secondary Accessions:
    • H3BSR3
    • O75707
    • O75708

    Protein attributes for HIRIP3 Gene

    Size:
    556 amino acids
    Molecular mass:
    61957 Da
    Quaternary structure:
    • Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2.

    Alternative splice isoforms for HIRIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIRIP3 Gene

Post-translational modifications for HIRIP3 Gene

Other Protein References for HIRIP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIRIP3 Gene

Domains & Families for HIRIP3 Gene

Protein Domains for HIRIP3 Gene

Suggested Antigen Peptide Sequences for HIRIP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HIRIP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HIRIP3 Gene

Function for HIRIP3 Gene

Molecular function for HIRIP3 Gene

GENATLAS Biochemistry:
HIRA-interacting protein 3,widely expressed an histone (H2B,H3) binding protein,directly interacting with the WD-repeat protein HIRA
UniProtKB/Swiss-Prot Function:
May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.

Gene Ontology (GO) - Molecular Function for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9710638
genes like me logo Genes that share ontologies with HIRIP3: view
genes like me logo Genes that share phenotypes with HIRIP3: view

Animal Models for HIRIP3 Gene

MGI Knock Outs for HIRIP3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIRIP3 Gene

Localization for HIRIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIRIP3 Gene

Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIRIP3 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS 17391060
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with HIRIP3: view

Pathways & Interactions for HIRIP3 Gene

SuperPathways for HIRIP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006333 chromatin assembly or disassembly TAS 9710638
genes like me logo Genes that share ontologies with HIRIP3: view

No data available for Pathways by source and SIGNOR curated interactions for HIRIP3 Gene

Drugs & Compounds for HIRIP3 Gene

(1) Additional Compounds for HIRIP3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Docosanoyl-CoA
  • Behenoyl-CoA
  • Behenoyl-Coenzyme A
genes like me logo Genes that share compounds with HIRIP3: view

Transcripts for HIRIP3 Gene

Unigene Clusters for HIRIP3 Gene

HIRA interacting protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIRIP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5:
SP6: - -
SP7: - - - - - - -
SP8: - - - - -
SP9:
SP10: -

Relevant External Links for HIRIP3 Gene

GeneLoc Exon Structure for
HIRIP3
ECgene alternative splicing isoforms for
HIRIP3

Expression for HIRIP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIRIP3 Gene

Protein differential expression in normal tissues from HIPED for HIRIP3 Gene

This gene is overexpressed in Cervix (38.7) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIRIP3 Gene



Protein tissue co-expression partners for HIRIP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HIRIP3 Gene:

HIRIP3

SOURCE GeneReport for Unigene cluster for HIRIP3 Gene:

Hs.567370

mRNA Expression by UniProt/SwissProt for HIRIP3 Gene:

Q9BW71-HIRP3_HUMAN
Tissue specificity: Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart.

Evidence on tissue expression from TISSUES for HIRIP3 Gene

  • Liver(4.3)
  • Blood(4.2)
  • Skin(4.2)
  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with HIRIP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIRIP3 Gene

Orthologs for HIRIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIRIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIRIP3 34 35
  • 99.16 (n)
dog
(Canis familiaris)
Mammalia HIRIP3 34 35
  • 82.44 (n)
cow
(Bos Taurus)
Mammalia HIRIP3 34 35
  • 80.17 (n)
rat
(Rattus norvegicus)
Mammalia Hirip3 34
  • 73.83 (n)
mouse
(Mus musculus)
Mammalia Hirip3 34 16 35
  • 70.86 (n)
oppossum
(Monodelphis domestica)
Mammalia HIRIP3 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIRIP3 35
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hirip3 35
  • 29 (a)
OneToOne
Species where no ortholog for HIRIP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIRIP3 Gene

ENSEMBL:
Gene Tree for HIRIP3 (if available)
TreeFam:
Gene Tree for HIRIP3 (if available)

Paralogs for HIRIP3 Gene

No data available for Paralogs for HIRIP3 Gene

Variants for HIRIP3 Gene

Sequence variations from dbSNP and Humsavar for HIRIP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000638423 -- 29,994,476(+) TGTTC(A/G)CTTTC intron-variant, upstream-variant-2KB, reference, synonymous-codon
rs1001278787 -- 29,998,006(+) GCCTG(A/G)AAGGT intron-variant, upstream-variant-2KB
rs1001640977 -- 29,995,506(+) CCCGC(A/G)CCCTT intron-variant, upstream-variant-2KB
rs1002589261 -- 29,991,940(+) CAGAC(C/G)TGCCA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1003059588 -- 29,995,361(+) AGCTC(C/T)TCCTC upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HIRIP3 Gene

Variant ID Type Subtype PubMed ID
esv3638378 CNV loss 21293372
esv997840 CNV deletion 20482838

Variation tolerance for HIRIP3 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.46; 54.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIRIP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIRIP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIRIP3 Gene

Disorders for HIRIP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HIRIP3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
velocardiofacial syndrome
  • 22q11 deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HIRIP3

Genetic Association Database (GAD)
HIRIP3
Human Genome Epidemiology (HuGE) Navigator
HIRIP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIRIP3
genes like me logo Genes that share disorders with HIRIP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HIRIP3 Gene

Publications for HIRIP3 Gene

  1. Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. (PMID: 9710638) Lorain S. … Lipinski M. (Mol. Cell. Biol. 1998) 2 3 4 22 64
  2. HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2. (PMID: 17391060) Assrir N. … Lipinski M. (Biol. Chem. 2007) 3 4 22 64
  3. Association and mutation analyses of 16p11.2 autism candidate genes. (PMID: 19242545) Kumar R.A. … Christian S.L. (PLoS ONE 2009) 3 46 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for HIRIP3 Gene

Sources for HIRIP3 Gene

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