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Aliases for HIRIP3 Gene

Aliases for HIRIP3 Gene

  • HIRA Interacting Protein 3 2 3
  • HIRA-Interacting Protein 3 2

External Ids for HIRIP3 Gene

Summaries for HIRIP3 Gene

Entrez Gene Summary for HIRIP3 Gene

  • The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for HIRIP3 Gene

HIRIP3 (HIRA Interacting Protein 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HIRIP3 Gene

  • May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.

Gene Wiki entry for HIRIP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIRIP3 Gene

Genomics for HIRIP3 Gene

Genomic Location for HIRIP3 Gene

Start:
29,992,321 bp from pter
End:
29,996,436 bp from pter
Size:
4,116 bases
Orientation:
Minus strand

Genomic View for HIRIP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIRIP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIRIP3 Gene

Regulatory Elements for HIRIP3 Gene

Proteins for HIRIP3 Gene

  • Protein details for HIRIP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW71-HIRP3_HUMAN
    Recommended name:
    HIRA-interacting protein 3
    Protein Accession:
    Q9BW71
    Secondary Accessions:
    • H3BSR3
    • O75707
    • O75708

    Protein attributes for HIRIP3 Gene

    Size:
    556 amino acids
    Molecular mass:
    61957 Da
    Quaternary structure:
    • Interacts with HIRA. Weak interaction with histones H2B and H3. Interacts with CK2.

    Alternative splice isoforms for HIRIP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIRIP3 Gene

Proteomics data for HIRIP3 Gene at MOPED

Post-translational modifications for HIRIP3 Gene

Other Protein References for HIRIP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIRIP3 Gene

Domains for HIRIP3 Gene

Protein Domains for HIRIP3 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with HIRIP3: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HIRIP3 Gene

Function for HIRIP3 Gene

Molecular function for HIRIP3 Gene

GENATLAS Biochemistry: HIRA-interacting protein 3,widely expressed an histone (H2B,H3) binding protein,directly interacting with the WD-repeat protein HIRA
UniProtKB/Swiss-Prot Function: May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones.

Gene Ontology (GO) - Molecular Function for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9710638
genes like me logo Genes that share ontologies with HIRIP3: view

Phenotypes for HIRIP3 Gene

GenomeRNAi human phenotypes for HIRIP3:
genes like me logo Genes that share phenotypes with HIRIP3: view

miRNA for HIRIP3 Gene

miRTarBase miRNAs that target HIRIP3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HIRIP3 Gene

Localization for HIRIP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIRIP3 Gene

Nucleus. Note=Nuclear throughout the cell cycle and is excluded from condensed chromatin during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIRIP3 Gene COMPARTMENTS Subcellular localization image for HIRIP3 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with HIRIP3: view

Pathways for HIRIP3 Gene

SuperPathways for HIRIP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIRIP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006333 chromatin assembly or disassembly TAS 9710638
genes like me logo Genes that share ontologies with HIRIP3: view

No data available for Pathways by source for HIRIP3 Gene

Compounds for HIRIP3 Gene

(1) HMDB Compounds for HIRIP3 Gene

Compound Synonyms Cas Number PubMed IDs
Docosanoyl-CoA
  • behenoyl-CoA
Not Available
genes like me logo Genes that share compounds with HIRIP3: view

Transcripts for HIRIP3 Gene

Unigene Clusters for HIRIP3 Gene

HIRA interacting protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIRIP3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - - - - - -
SP5:
SP6: - -
SP7: - - - - - - -
SP8: - - - - -
SP9:
SP10: -

Relevant External Links for HIRIP3 Gene

GeneLoc Exon Structure for
HIRIP3
ECgene alternative splicing isoforms for
HIRIP3

Expression for HIRIP3 Gene

mRNA expression in normal human tissues for HIRIP3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIRIP3 Gene

SOURCE GeneReport for Unigene cluster for HIRIP3 Gene Hs.567370

mRNA Expression by UniProt/SwissProt for HIRIP3 Gene

Q9BW71-HIRP3_HUMAN
Tissue specificity: Widely expressed. Isoform 1 is predominant in skeletal muscle. Isoform 2 is predominant in liver and heart.
genes like me logo Genes that share expressions with HIRIP3: view

Orthologs for HIRIP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIRIP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIRIP3 36
  • 99.16 (n)
  • 98.92 (a)
HIRIP3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIRIP3 36
  • 80.17 (n)
  • 73.61 (a)
HIRIP3 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIRIP3 36
  • 82.44 (n)
  • 76.34 (a)
HIRIP3 37
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hirip3 36
  • 70.86 (n)
  • 61.71 (a)
Hirip3 16
Hirip3 37
  • 54 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HIRIP3 37
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hirip3 36
  • 73.83 (n)
  • 65.53 (a)
lizard
(Anolis carolinensis)
Reptilia HIRIP3 37
  • 28 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hirip3 37
  • 29 (a)
OneToOne
Species with no ortholog for HIRIP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIRIP3 Gene

ENSEMBL:
Gene Tree for HIRIP3 (if available)
TreeFam:
Gene Tree for HIRIP3 (if available)

Paralogs for HIRIP3 Gene

No data available for Paralogs for HIRIP3 Gene

Variants for HIRIP3 Gene

Sequence variations from dbSNP and Humsavar for HIRIP3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1135662 -- 29,993,689(+) CGCTC(C/T)TTGTG missense, reference, synonymous-codon
rs11643314 - 29,993,317(+) CTCCC(A/C)TGGGG utr-variant-3-prime, reference, missense
rs35070098 -- 29,994,145(-) GCAGC(A/G)AGGAC intron-variant, missense, reference
rs35431046 - 29,993,479(-) TGTTG(C/T)GAACA utr-variant-3-prime, reference, missense
rs77645102 -- 29,993,475(+) ATGAT(A/G)TTCGC utr-variant-3-prime, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HIRIP3 Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294
esv997840 CNV Deletion 20482838

Relevant External Links for HIRIP3 Gene

HapMap Linkage Disequilibrium report
HIRIP3

Disorders for HIRIP3 Gene

(2) University of Copenhagen DISEASES for HIRIP3 Gene

Relevant External Links for HIRIP3

Genetic Association Database (GAD)
HIRIP3
Human Genome Epidemiology (HuGE) Navigator
HIRIP3
genes like me logo Genes that share disorders with HIRIP3: view

No data available for UniProtKB/Swiss-Prot for HIRIP3 Gene

Publications for HIRIP3 Gene

  1. Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. (PMID: 9710638) Lorain S. … Lipinski M. (Mol. Cell. Biol. 1998) 2 3 4 23
  2. HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2. (PMID: 17391060) Assrir N. … Lipinski M. (Biol. Chem. 2007) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for HIRIP3 Gene

Sources for HIRIP3 Gene

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