HIRA Gene
protein-coding GIFtS: 59
GCID: GC22M019318
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|
HIR histone cell cycle regulation defective homolog A (S....(Previous name: HIR (histone cell cycle regulation defective) homolog A...)
(Previous symbol: TUPLE1)
| |
Aliases
for HIRA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HIR Histone Cell Cycle Regulation Defective Homolog A (S. Cerevisiae)1 2 | | HIR (Histone Cell Cycle Regulation Defective) Homolog A (S. Cerevisiae)1 | | TUPLE11 2 3 5 | | DiGeorge Critical Region Gene 12 | | DGCR11 2 3 | | Protein HIRA2 | | TUP11 2 | | HIR3 | | TUP1-Like Enhancer Of Split Protein 12 3 | | |
Export aliases for HIRA gene to outside databasesPrevious GC identifers: GC22M016258 GC22M017692 GC22M002938 |
Summaries
for HIRA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIRA:
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs ofthis gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. Thisgene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likelymediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate genein some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disruptnormal embryonic development. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: HIRA_HUMAN, P54198Function: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodicrepression of histone gene transcription during the cell cycle. Required for the formation of senescence-associatedheterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit
Gene Wiki entry for HIRA
|
Genomic Views
for HIRA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011519.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIRA gene promoter:
TBP AML1a AP-1 ATF-2 USF-1:USF-2 PPAR-gamma1 Ik-2 USF-1 c-Jun PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIRA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIRA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.2HIRA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M019318: view genomic region
(about GC identifiers)
Start:
|
19,318,221 bp from pter |
End:
|
19,435,224 bp from pter |
Size:
|
117,004 bases |
Orientation:
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minus strand |
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Proteins
for HIRA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIRA_HUMAN, P54198 (See
protein sequence)Recommended Name: Protein HIRA Size: 1017 amino acids; 111835 Da
Subunit: Interacts with histone H3F3B, PAX3 and PAX7 (By similarity). Interacts with CCNA1, HIRIP3, NFU1/HIRIP5 andhistone H2B. Part of a complex which includes ASF1A, CABIN1, histone H3.3, histone H4 and UBN1
Subcellular location: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus.Localizes to PML bodies immediately prior to onset of senescence
Developmental stage: Expressed during embryogenesis
Sequence caution: Sequence=CAA53044.1; Type=Erroneous initiation; Sequence=CAA54721.1; Type=Erroneous initiation;Sequence=CAA57436.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for HIRA:2I32 (3D)
Secondary accessions: Q05BU9 Q8IXN2Alternative splicing: 2 isoforms: P54198-1 P54198-2 Explore the universe of human proteins at neXtProt for HIRA: NX_P54198
Post-translational modifications:
Sumoylated1
Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-555 in vitro. Also phosphorylated on Thr-555 and Ser-687 in vivo1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P54198
HIRA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003316.3
ENSEMBL proteins: ENSP00000345350 ENSP00000263208 ENSP00000404792 ENSP00000446073 ENSP00000441870
Human Recombinant Protein Products for HIRA:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
HIRA for ontologies About GeneDecksing
HIRA Antibody Products:
Assay Products for HIRA: |
Protein
Domains /
Families
for HIRA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIRA for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P54198ProtoNet protein and cluster: P54198 2 Blocks protein families: IPB001680 G-protein beta WD-40 repeat signature IPB011494 TUP1-like enhancer of split
UniProtKB/Swiss-Prot: HIRA_HUMAN, P54198Similarity: Belongs to the WD repeat HIR1 familySimilarity: Contains 8 WD repeats |
Function
for HIRA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HIRA_HUMAN, P54198Function: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodicrepression of histone gene transcription during the cell cycle. Required for the formation of senescence-associatedheterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit Genatlas biochemistry entry for HIRA:histone cell cycle regulation defective,nuclear localization,S cerevisiae,homolog A,expressed in the neuralcrest,transcriptional repressors HIR1,HIR2,interacting with core histones H2B and H4,histone binding proteins andPAX1,required for cardiac outflow tract septation,commonly deleted in DiGeorge syndrome (see DGCR,TUPLE1)
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
HIRA for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for HIRA:
10 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Hira):
HIRA for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for HIRA: Hiratm1Pjs Hiratm2Pjs
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIRA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIRA (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HIRA (NM_003325) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIRA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIRA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIRA |
|
Pathways & Interactions
for HIRA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIRA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/864 Interacting proteins for HIRA (P541982, 3 ENSP000002632084) via UniProtKB, MINT, STRING, and/or I2D (see all 864)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001649 | osteoblast differentiation |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 9731536 | | GO:0007369 | gastrulation |
IEA | -- |
HIRA for ontologies About GeneDecksing
|
Drugs & Compounds
for HIRA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HIRA
Search CenterWatch for drugs/clinical trials and news about HIRA
|
Transcripts
for HIRA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIRA gene: NM_003325.3 Unigene Cluster for HIRA: HIR histone cell cycle regulation defective homolog A (S. cerevisiae) Hs.474206 [show with all ESTs]Unigene Representative Sequence: BC0398356 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340170(uc010grn.1) ENST00000263208(uc002zpf.1 uc011agx.1 uc010gro.2)
ENST00000464189 ENST00000452818 ENST00000541063 ENST00000546308
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIRA (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIRA (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HIRA (NM_003325) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIRA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIRA |
Additional cDNA sequence: AK289809.1 AK299950.1 AK302835.1 AK308642.1 BC019020.1 BC032721.1 BC039835.1 CR456503.1 X75296.1 X77633.1 X81844.1 X89887.1 24 DOTS entries: DT.86855487 DT.100782808 DT.120652493 DT.95270660 DT.120652543 DT.100024516 DT.440867 DT.75110689 DT.95200588 DT.95270659 DT.100665902 DT.100703514 DT.100782809 DT.120652494 DT.86855486 DT.100782803 DT.120652462 DT.120652505 DT.120652556 DT.120652622 DT.92425739 DT.120652607 DT.452035 DT.99939245 24/158 AceView cDNA sequences (see all 158): BQ638682 H55676 AL040645 H55671 AA381611 BC039835 BI833228 AU121562 F11555 F15217 BM551028 AI801803 AI632005 BU508868 NM_003325 AI444984 BI914128 BG911776 H55293 CB155691 H55289 AI192555 CR456503 BM758353
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HIRA (see all 11) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | · | 22c | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HIRA
|
Expression
for HIRA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIRA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See HIRA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIRA
SOURCE GeneReport for Unigene cluster: Hs.474206
UniProtKB/Swiss-Prot: HIRA_HUMAN, P54198Tissue specificity: Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain,heart, liver, lung, and placenta
SABiosciences Custom PCR Arrays for HIRA
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIRA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIRA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIRA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIRA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIRA |
Orthologs
for HIRA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HIRA gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for HIRA (if available)
TreeFam Gene Tree for HIRA (if available) |
Paralogs
for HIRA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIRA gene
2 SIMAP similar genes for HIRA using alignment to 4 protein entries: HIRA_HUMAN (see all proteins):C22orf39 PF20
HIRA for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HIRA
PGOHUM00000238700
|
Genomic Variants
for HIRA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIRA (19318221 - 19435224 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for HIRA
2 CNVs: 73716 31071 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIRA |
|
Disorders
/ Diseases
for HIRA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIRA for disorders About GeneDecksing
OMIM gene information: 600237
OMIM disorders: --
12  diseases for HIRA: About MalaCardsdigeorge syndrome ventricular septal defect developmental disabilities pulmonary valve stenosis
autism spectrum disorder velocardiofacial syndrome cystic lymphangioma tetralogy of fallot
lymphangioma aldosteronism retinoblastoma meningioma
4 diseases from the University of Copenhagen DISEASES database for HIRA:DiGeorge syndrome Velocardiofacial syndrome Tetralogy of Fallot Cystic lymphangioma 4 Novoseek disease relationships for HIRA gene About this table
Human Genome Epidemiology (HuGE) Navigator: HIRA (6 documents)
Export disorders for HIRA gene to outside databases
|
Publications
for HIRA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIRA gene, integrated from 9 sources (see all 82):
(articles sorted by number of sources associating them with HIRA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region. (PubMed id 7633437)1, 2, 3, 9 Lamour V....Lipinski M. (1995)
- Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. (PubMed id 8111380)1, 2, 3 Halford S.... Scambler P.J. (1993)
- HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. (PubMed id 11238922)1, 2, 9 Hall C.... Adams P.D. (2001)
- Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA. (PubMed id 9710638)1, 2, 9 Lorain S.... Lipinski M. (1998)
- HIRA, a mammalian homologue of Saccharomyces cerevisi ae transcriptional co-repressors, interacts with Pax3. (PubMed id 9731536)1, 3, 9 Magnaghi P....Scambler P.J. (1998)
- Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. (PubMed id 15621527)1, 2, 9 Zhang R.... Adams P.D. (2005)
- Structural organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22. (PubMed id 8681138)1, 2, 9 Lorain S....Lipinski M. (1996)
- Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. (PubMed id 16980972)1, 2, 9 Tang Y.... Marmorstein R. (2006)
- Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells. (PubMed id 19029251)1, 2, 9 Banumathy G....Adams P.D. (2008)
- Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis. (PubMed id 14718166)1, 2, 9 Tagami H.... Nakatani Y. (2004)
|
External Searches for HIRA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIRA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIRA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIRA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HIRA | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HIRA gene:
Search GeneIP for patents involving HIRA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HIRA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
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| | |  | OriGene Antibodies for HIRA | | OriGene shRNA RFP for HIRA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIRA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIRA | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIRA | | OriGene 3'-UTR Clone for HIRA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIRA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIRA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIRA | | OriGene Custom Protein Services for HIRA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIRA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIRA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIRA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIRA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIRA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIRA |
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| | | | Search Tocris compounds for HIRA |
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 | | | HIRA Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIRA |
|  |  |  |  | | | | ThermoFisher Antibodies for HIRA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIRA |
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