Aliases for HIRA Gene
External Ids for HIRA Gene
Previous HGNC Symbols for HIRA Gene
Previous GeneCards Identifiers for HIRA Gene
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
GeneCards Summary for HIRA Gene
HIRA (Histone Cell Cycle Regulator) is a Protein Coding gene. Diseases associated with HIRA include Digeorge Syndrome and Velocardiofacial Syndrome. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Cellular Senescence (REACTOME). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity.
UniProtKB/Swiss-Prot for HIRA Gene
Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.