HIPK4 Gene
protein-coding GIFtS: 45
GCID: GC19M040885
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|
homeodomain interacting protein kinase 4
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Aliases
for HIPK4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Homeodomain Interacting Protein Kinase 41 2 | | EC 2.7.11.13 8 | | FLJ328181 | | Homeodomain-Interacting Protein Kinase 42 |
Export aliases for HIPK4 gene to outside databasesPrevious GC identifers: GC19M045577 GC19M037320 |
Summaries
for HIPK4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HIPK4_HUMAN, Q8NE63Function: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter(By similarity). May act as a corepressor of transcription factors (Potential)
|
Genomic Views
for HIPK4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIPK4 gene promoter:
SRF Pax-5 SRF (504 AA) AP-4 XBP-1 E47 PPAR-gamma1 Hand1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIPK4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIPK4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2HIPK4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M040885: view genomic region
(about GC identifiers)
Start:
|
40,885,178 bp from pter |
End:
|
40,896,094 bp from pter |
Size:
|
10,917 bases |
Orientation:
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minus strand |
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Proteins
for HIPK4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIPK4_HUMAN, Q8NE63 (See
protein sequence)Recommended Name: Homeodomain-interacting protein kinase 4 Size: 616 amino acids; 69425 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=BAB71458.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: A8K863 Q96M54Explore the universe of human proteins at neXtProt for HIPK4: NX_Q8NE63
Post-translational modifications:
Autophosphorylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NE63
2 DME Specific Peptides for HIPK4 (Q8NE63)
HIPK4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_653286.2
ENSEMBL proteins: ENSP00000291823
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
HIPK4 for ontologies About GeneDecksing
HIPK4 Antibody Products:
Assay Products for HIPK4: |
Protein
Domains /
Families
for HIPK4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIPK4 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NE63ProtoNet protein and cluster: Q8NE63 UniProtKB/Swiss-Prot: HIPK4_HUMAN, Q8NE63Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamilySimilarity: Contains 1 protein kinase domain |
Function
for HIPK4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HIPK4_HUMAN, Q8NE63Function: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter(By similarity). May act as a corepressor of transcription factors (Potential)Catalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HIPK4 (NM_144685) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIPK4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
HIPK4 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for HIPK4:
|
Pathways & Interactions
for HIPK4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIPK4
|
Drugs & Compounds
for HIPK4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HIPK4
Search CenterWatch for drugs/clinical trials and news about HIPK4
|
Transcripts
for HIPK4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIPK4 gene: NM_144685.3 Unigene Cluster for HIPK4: Homeodomain interacting protein kinase 4 Hs.79363 [show with all ESTs]Unigene Representative Sequence: NM_1446851 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000291823(uc002onp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HIPK4 (NM_144685) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIPK4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK4 |
Additional cDNA sequence: AK057380.1 AK292228.1 AK301713.1 AK302301.1 BC034501.2 3 DOTS entries: DT.100016640 DT.100667090 DT.435710 18 AceView cDNA sequences: NM_144685 AK057380 BC034501 BI827147 AI001807 BX099852 AI806773 BM554291 CD637134 BG772881 CD637132 BU678003 CD637135 CD637133 BI561789 BG771831 BG720082 BF950933
GeneLoc Exon Structure
|
Expression
for HIPK4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIPK4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCACCGGGCA
About this image
See HIPK4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIPK4
SOURCE GeneReport for Unigene cluster: Hs.79363
SABiosciences Custom PCR Arrays for HIPK4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIPK4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HIPK4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIPK4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIPK4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK4 |
Orthologs
for HIPK4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HIPK4 gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
HIPK46 |
-- |
57(a) |
1 ↔ 1 |
LGf(2208199-2211558) |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
BX073989.12 |
-- |
74.16(n) |
|
BX073989.1 |
ENSEMBL Gene Tree for HIPK4 (if available)
TreeFam Gene Tree for HIPK4 (if available) |
Paralogs
for HIPK4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIPK4 gene
- DYRK32 DYRK22 DYRK1A2 HIPK12 DYRK42 HIPK32 HIPK22 DYRK1B2
5 SIMAP similar genes for HIPK4 using alignment to 1 protein entry: HIPK4_HUMAN:HIPK1 HIPK2 CDK2 CDK3 CDK4
HIPK4 for paralogs About GeneDecksing
|
Genomic Variants
for HIPK4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIPK4 (40885178 - 40896094 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HIPK4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIPK4 |
|
Disorders
/ Diseases
for HIPK4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIPK4 for disorders About GeneDecksing
OMIM gene information: 611712
OMIM disorders: --
1  disease for HIPK4: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: HIPK4 (2 documents)
Export disorders for HIPK4 gene to outside databases
|
Publications
for HIPK4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIPK4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HIPK4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. (PubMed id 18022393)1 Arai S.... Kurokawa R. (2007)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for HIPK4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIPK4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIPK4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIPK4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HIPK4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HIPK4 gene:
Search GeneIP for patents involving HIPK4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HIPK4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HIPK4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIPK4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIPK4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIPK4 | | OriGene 3'-UTR Clone for HIPK4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| |  |  |  |  | | | | |
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 | | | HIPK4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK4 |
|  |  |  | | | | ThermoFisher Antibodies for HIPK4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK4 |
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