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Aliases for HIPK4 Gene

Aliases for HIPK4 Gene

  • Homeodomain Interacting Protein Kinase 4 2 3
  • EC 4 63

External Ids for HIPK4 Gene

Summaries for HIPK4 Gene

GeneCards Summary for HIPK4 Gene

HIPK4 (Homeodomain Interacting Protein Kinase 4) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is DYRK1B.

UniProtKB/Swiss-Prot for HIPK4 Gene

  • Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIPK4 Gene

Genomics for HIPK4 Gene

Genomic Location for HIPK4 Gene

40,379,271 bp from pter
40,390,187 bp from pter
10,917 bases
Minus strand

Genomic View for HIPK4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIPK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIPK4 Gene

Regulatory Elements for HIPK4 Gene

Proteins for HIPK4 Gene

  • Protein details for HIPK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeodomain-interacting protein kinase 4
    Protein Accession:
    Secondary Accessions:
    • A8K863
    • Q96M54

    Protein attributes for HIPK4 Gene

    616 amino acids
    Molecular mass:
    69425 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB71458.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for HIPK4 Gene

Proteomics data for HIPK4 Gene at MOPED

Selected DME Specific Peptides for HIPK4 Gene

Post-translational modifications for HIPK4 Gene

Other Protein References for HIPK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for HIPK4 Gene

Gene Families for HIPK4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.:
    • Q8NE63
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.:
    • Q8NE63
genes like me logo Genes that share domains with HIPK4: view

Function for HIPK4 Gene

Molecular function for HIPK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).

Enzyme Numbers (IUBMB) for HIPK4 Gene

Gene Ontology (GO) - Molecular Function for HIPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HIPK4: view

Phenotypes for HIPK4 Gene

genes like me logo Genes that share phenotypes with HIPK4: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HIPK4 Gene

Localization for HIPK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIPK4 Gene


Subcellular locations from

Jensen Localization Image for HIPK4 Gene COMPARTMENTS Subcellular localization image for HIPK4 gene
Compartment Confidence
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HIPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HIPK4: view

Pathways for HIPK4 Gene

SuperPathways for HIPK4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation --
GO:0016572 histone phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IEA --
GO:0046777 protein autophosphorylation IEA --
GO:1901796 regulation of signal transduction by p53 class mediator IEA --
genes like me logo Genes that share ontologies with HIPK4: view

No data available for Pathways by source for HIPK4 Gene

Transcripts for HIPK4 Gene

mRNA/cDNA for HIPK4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIPK4 Gene

Homeodomain interacting protein kinase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIPK4 Gene

No ASD Table

Relevant External Links for HIPK4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIPK4 Gene

mRNA expression in normal human tissues for HIPK4 Gene

mRNA differential expression in normal tissues according to GTEx for HIPK4 Gene

This gene is overexpressed in Testis (15.9), Brain - Nucleus accumbens (basal ganglia) (5.4), and Brain - Cortex (4.0).

SOURCE GeneReport for Unigene cluster for HIPK4 Gene Hs.79363

genes like me logo Genes that share expressions with HIPK4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for HIPK4 Gene

Orthologs for HIPK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIPK4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HIPK4 35
  • 98.32 (n)
  • 98.21 (a)
HIPK4 36
  • 98 (a)
(Bos Taurus)
Mammalia HIPK4 35
  • 87.86 (n)
  • 88.13 (a)
HIPK4 36
  • 88 (a)
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
HIPK4 35
  • 88.65 (n)
  • 89.74 (a)
(Mus musculus)
Mammalia Hipk4 35
  • 83.58 (n)
  • 87.32 (a)
Hipk4 16
Hipk4 36
  • 87 (a)
(Monodelphis domestica)
Mammalia HIPK4 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia HIPK4 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Hipk4 35
  • 83.25 (n)
  • 86.67 (a)
(Anolis carolinensis)
Reptilia HIPK4 36
  • 58 (a)
(Caenorhabditis elegans)
Secernentea C36B7.1 36
  • 19 (a)
C36B7.2 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAK1 36
  • 15 (a)
Species with no ortholog for HIPK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HIPK4 Gene

Gene Tree for HIPK4 (if available)
Gene Tree for HIPK4 (if available)

Paralogs for HIPK4 Gene

Selected SIMAP similar genes for HIPK4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIPK4: view

Variants for HIPK4 Gene

Sequence variations from dbSNP and Humsavar for HIPK4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1968358 -- 40,385,074(-) ttcta(G/T)atctg intron-variant
rs1968359 -- 40,385,031(-) gaaga(A/G)taggg intron-variant
rs1975023 -- 40,381,814(-) cacat(A/C)caaaa intron-variant
rs1985669 -- 40,383,304(-) gagtt(C/T)aagac intron-variant
rs2278227 -- 40,379,164(-) CCCAG(C/T)TGACC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HIPK4 Gene

Variant ID Type Subtype PubMed ID
nsv833831 CNV Loss 17160897
dgv3867n71 CNV Loss 21882294

Relevant External Links for HIPK4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIPK4 Gene

Disorders for HIPK4 Gene

Relevant External Links for HIPK4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HIPK4: view

No data available for UniProtKB/Swiss-Prot for HIPK4 Gene

Publications for HIPK4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9. (PMID: 18022393) Arai S. … Kurokawa R. (FEBS Lett. 2007) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for HIPK4 Gene

  • Addgene plasmids for HIPK4

Sources for HIPK4 Gene

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