Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIPK4 Gene

Aliases for HIPK4 Gene

  • Homeodomain Interacting Protein Kinase 4 2 3 5
  • EC 2.7.11.1 4 63

External Ids for HIPK4 Gene

Previous GeneCards Identifiers for HIPK4 Gene

  • GC19M045577
  • GC19M040885
  • GC19M037320

Summaries for HIPK4 Gene

GeneCards Summary for HIPK4 Gene

HIPK4 (Homeodomain Interacting Protein Kinase 4) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DYRK1B.

UniProtKB/Swiss-Prot for HIPK4 Gene

  • Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIPK4 Gene

Genomics for HIPK4 Gene

Regulatory Elements for HIPK4 Gene

Genomic Location for HIPK4 Gene

Chromosome:
19
Start:
40,379,271 bp from pter
End:
40,390,221 bp from pter
Size:
10,951 bases
Orientation:
Minus strand

Genomic View for HIPK4 Gene

Genes around HIPK4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIPK4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIPK4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIPK4 Gene

Proteins for HIPK4 Gene

  • Protein details for HIPK4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE63-HIPK4_HUMAN
    Recommended name:
    Homeodomain-interacting protein kinase 4
    Protein Accession:
    Q8NE63
    Secondary Accessions:
    • A8K863
    • Q96M54

    Protein attributes for HIPK4 Gene

    Size:
    616 amino acids
    Molecular mass:
    69425 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71458.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for HIPK4 Gene

Proteomics data for HIPK4 Gene at MOPED

Selected DME Specific Peptides for HIPK4 Gene

Post-translational modifications for HIPK4 Gene

Other Protein References for HIPK4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for HIPK4 Gene

Gene Families for HIPK4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NE63

UniProtKB/Swiss-Prot:

HIPK4_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
genes like me logo Genes that share domains with HIPK4: view

Function for HIPK4 Gene

Molecular function for HIPK4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential).

Enzyme Numbers (IUBMB) for HIPK4 Gene

Gene Ontology (GO) - Molecular Function for HIPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HIPK4: view
genes like me logo Genes that share phenotypes with HIPK4: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIPK4 Gene

Localization for HIPK4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIPK4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIPK4 Gene COMPARTMENTS Subcellular localization image for HIPK4 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for HIPK4 Gene

Pathways & Interactions for HIPK4 Gene

SuperPathways for HIPK4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIPK4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016572 histone phosphorylation IEA --
genes like me logo Genes that share ontologies with HIPK4: view

No data available for Pathways by source and SIGNOR curated interactions for HIPK4 Gene

Drugs & Compounds for HIPK4 Gene

No Compound Related Data Available

Transcripts for HIPK4 Gene

mRNA/cDNA for HIPK4 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIPK4 Gene

Homeodomain interacting protein kinase 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIPK4 Gene

No ASD Table

Relevant External Links for HIPK4 Gene

GeneLoc Exon Structure for
HIPK4
ECgene alternative splicing isoforms for
HIPK4

Expression for HIPK4 Gene

mRNA expression in normal human tissues for HIPK4 Gene

mRNA differential expression in normal tissues according to GTEx for HIPK4 Gene

This gene is overexpressed in Testis (x15.9), Brain - Nucleus accumbens (basal ganglia) (x5.4), and Brain - Cortex (x4.0).

SOURCE GeneReport for Unigene cluster for HIPK4 Gene Hs.79363

genes like me logo Genes that share expression patterns with HIPK4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HIPK4 Gene

Orthologs for HIPK4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIPK4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIPK4 35
  • 87.86 (n)
  • 88.13 (a)
HIPK4 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIPK4 35
  • 88.65 (n)
  • 89.74 (a)
-- 36
  • 83 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Hipk4 35
  • 83.58 (n)
  • 87.32 (a)
Hipk4 16
Hipk4 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIPK4 35
  • 98.32 (n)
  • 98.21 (a)
HIPK4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hipk4 35
  • 83.25 (n)
  • 86.67 (a)
oppossum
(Monodelphis domestica)
Mammalia HIPK4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIPK4 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIPK4 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C36B7.1 36
  • 19 (a)
ManyToMany
C36B7.2 36
  • 20 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAK1 36
  • 15 (a)
OneToMany
Species with no ortholog for HIPK4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HIPK4 Gene

ENSEMBL:
Gene Tree for HIPK4 (if available)
TreeFam:
Gene Tree for HIPK4 (if available)

Paralogs for HIPK4 Gene

(5) SIMAP similar genes for HIPK4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIPK4: view

Variants for HIPK4 Gene

Sequence variations from dbSNP and Humsavar for HIPK4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs11670988 - 40,381,086(+) TTAGC(A/C/T)GACTG reference, missense
rs34434715 - 40,389,587(+) GGGCG(C/G/T)GAAGT reference, missense
rs55964225 - 40,384,094(+) CTTCA(C/T)GTAGC reference, missense
rs55760165 - 40,380,849(+) CGGGC(A/G)TGGGG reference, missense
rs56365273 - 40,380,835(+) TTCTG(C/T)GGCCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HIPK4 Gene

Variant ID Type Subtype PubMed ID
nsv833831 CNV Loss 17160897
dgv3867n71 CNV Loss 21882294

Variation tolerance for HIPK4 Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.82; 67.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIPK4 Gene

HapMap Linkage Disequilibrium report
HIPK4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIPK4 Gene

Disorders for HIPK4 Gene

Relevant External Links for HIPK4

Genetic Association Database (GAD)
HIPK4
Human Genome Epidemiology (HuGE) Navigator
HIPK4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIPK4

No disorders were found for HIPK4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIPK4 Gene

Publications for HIPK4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK). (PMID: 25630557) van der Laden J. … Becker W. (Cell Commun. Signal 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for HIPK4 Gene

Sources for HIPK4 Gene

Back to Top

Content