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Aliases for HIPK3 Gene

Aliases for HIPK3 Gene

  • Homeodomain Interacting Protein Kinase 3 2 3
  • DYRK6 3 4 6
  • PKY 3 4 6
  • Androgen Receptor-Interacting Nuclear Protein Kinase 3 4
  • Fas-Interacting Serine/Threonine-Protein Kinase 3 4
  • Homeodomain-Interacting Protein Kinase 3 2 3
  • Homolog Of Protein Kinase YAK1 3 4
  • EC 2.7.11.1 4 63
  • FIST3 3 4
  • ANPK 3 4
  • FIST 3 4
  • YAK1 3

External Ids for HIPK3 Gene

Previous GeneCards Identifiers for HIPK3 Gene

  • GC11P034811
  • GC11P033957
  • GC11P033318
  • GC11P033272
  • GC11P033264
  • GC11P033235
  • GC11P032973

Summaries for HIPK3 Gene

GeneCards Summary for HIPK3 Gene

HIPK3 (Homeodomain Interacting Protein Kinase 3) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is DYRK1B.

UniProtKB/Swiss-Prot for HIPK3 Gene

  • Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Gene Wiki entry for HIPK3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIPK3 Gene

Genomics for HIPK3 Gene

Regulatory Elements for HIPK3 Gene

Genomic Location for HIPK3 Gene

Start:
33,256,672 bp from pter
End:
33,357,023 bp from pter
Size:
100,352 bases
Orientation:
Plus strand

Genomic View for HIPK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIPK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIPK3 Gene

Proteins for HIPK3 Gene

  • Protein details for HIPK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H422-HIPK3_HUMAN
    Recommended name:
    Homeodomain-interacting protein kinase 3
    Protein Accession:
    Q9H422
    Secondary Accessions:
    • O14632
    • Q2PBG4
    • Q2PBG5
    • Q92632
    • Q9HAS2

    Protein attributes for HIPK3 Gene

    Size:
    1215 amino acids
    Molecular mass:
    133743 Da
    Quaternary structure:
    • Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1. Binds to NR5A1/SF1, SPEN/MINT and RUNX2.

    Alternative splice isoforms for HIPK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIPK3 Gene

Proteomics data for HIPK3 Gene at MOPED

Post-translational modifications for HIPK3 Gene

Domains for HIPK3 Gene

Gene Families for HIPK3 Gene

Suggested Antigen Peptide Sequences for HIPK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H422

UniProtKB/Swiss-Prot:

HIPK3_HUMAN :
  • Q9H422
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
genes like me logo Genes that share domains with HIPK3: view

Function for HIPK3 Gene

Molecular function for HIPK3 Gene

GENATLAS Biochemistry: homeodomain interacting protein kinase 3,highly expressed in heart and muscle tissue,localizing in nuclear speckles,corepressor for homeo domain transcription factors,maybe involved in cell cycle regulation,over-expressed in multidrugg resistant cell-lines
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

Enzyme Numbers (IUBMB) for HIPK3 Gene

Gene Ontology (GO) - Molecular Function for HIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 14766760
GO:0004674 protein serine/threonine kinase activity ISS 11034606
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HIPK3: view

Phenotypes for HIPK3 Gene

genes like me logo Genes that share phenotypes with HIPK3: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for HIPK3 Gene

Localization for HIPK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIPK3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIPK3 Gene COMPARTMENTS Subcellular localization image for HIPK3 gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane --
GO:0016605 PML body IEA --
genes like me logo Genes that share ontologies with HIPK3: view

Pathways for HIPK3 Gene

SuperPathways for HIPK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIPK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IDA 14766760
GO:0006915 apoptotic process IEA --
GO:0009103 lipopolysaccharide biosynthetic process --
GO:0009299 mRNA transcription IDA 17210646
genes like me logo Genes that share ontologies with HIPK3: view

No data available for Pathways by source for HIPK3 Gene

Compounds for HIPK3 Gene

(2) HMDB Compounds for HIPK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(2) Novoseek inferred chemical compound relationships for HIPK3 Gene

Compound -log(P) Hits PubMed IDs
threonine 36.2 2
serine 22 2
genes like me logo Genes that share compounds with HIPK3: view

Transcripts for HIPK3 Gene

Unigene Clusters for HIPK3 Gene

Homeodomain interacting protein kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIPK3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2: -

Relevant External Links for HIPK3 Gene

GeneLoc Exon Structure for
HIPK3
ECgene alternative splicing isoforms for
HIPK3

Expression for HIPK3 Gene

mRNA expression in normal human tissues for HIPK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HIPK3 Gene

SOURCE GeneReport for Unigene cluster for HIPK3 Gene Hs.201918

mRNA Expression by UniProt/SwissProt for HIPK3 Gene

Q9H422-HIPK3_HUMAN
Tissue specificity: Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes. Not found in liver and lung.
genes like me logo Genes that share expressions with HIPK3: view

No data available for mRNA differential expression in normal tissues for HIPK3 Gene

Orthologs for HIPK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIPK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIPK3 35
  • 99.75 (n)
  • 99.67 (a)
HIPK3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIPK3 35
  • 93.31 (n)
  • 94.65 (a)
HIPK3 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIPK3 35
  • 94.21 (n)
  • 95.47 (a)
HIPK3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hipk3 35
  • 88.89 (n)
  • 90.76 (a)
Hipk3 16
Hipk3 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HIPK3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIPK3 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hipk3 35
  • 88.83 (n)
  • 90.68 (a)
chicken
(Gallus gallus)
Aves HIPK3 35
  • 80.56 (n)
  • 81.88 (a)
HIPK3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIPK3 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10538 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hipk3 35
  • 72.59 (n)
  • 71.13 (a)
zebrafish
(Danio rerio)
Actinopterygii hipk3a 36
  • 60 (a)
OneToMany
hipk3b 35
  • 67.08 (n)
  • 67.34 (a)
hipk3b 36
  • 61 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hipk 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpk-1 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAK1 36
  • 25 (a)
OneToMany
Species with no ortholog for HIPK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIPK3 Gene

ENSEMBL:
Gene Tree for HIPK3 (if available)
TreeFam:
Gene Tree for HIPK3 (if available)

Paralogs for HIPK3 Gene

Selected SIMAP similar genes for HIPK3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HIPK3: view

Variants for HIPK3 Gene

Sequence variations from dbSNP and Humsavar for HIPK3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10600 -- 33,356,663(+) ATCCA(A/G)TGATA utr-variant-3-prime
rs169106 -- 33,286,095(+) CGTTT(C/T)TAGGG intron-variant, upstream-variant-2KB
rs171960 -- 33,323,630(-) cttcc(C/T)caaac intron-variant
rs185549 -- 33,330,941(-) gaacc(A/C)ctgca intron-variant
rs187867 -- 33,300,179(-) tagta(A/G)aagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIPK3 Gene

Variant ID Type Subtype PubMed ID
dgv1065n71 CNV Gain 21882294
nsv467786 CNV Gain 19166990
nsv521130 CNV Gain 19592680
dgv1067n71 CNV Gain 21882294
nsv897202 CNV Gain 21882294
nsv897203 CNV Gain 21882294
esv2677639 CNV Deletion 23128226
dgv11n68 CNV Gain 17160897

Relevant External Links for HIPK3 Gene

HapMap Linkage Disequilibrium report
HIPK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIPK3 Gene

Disorders for HIPK3 Gene

(1) Novoseek inferred disease relationships for HIPK3 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for HIPK3

Genetic Association Database (GAD)
HIPK3
Human Genome Epidemiology (HuGE) Navigator
HIPK3
genes like me logo Genes that share disorders with HIPK3: view

No data available for UniProtKB/Swiss-Prot for HIPK3 Gene

Publications for HIPK3 Gene

  1. Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1. (PMID: 9373137) Begley D.A. … Abraham I. (Gene 1997) 2 3 4 23
  2. JNK regulates HIPK3 expression and promotes resistance to Fas- mediated apoptosis in DU 145 prostate carcinoma cells. (PMID: 14766760) Curtin J.F. … Cotter T.G. (J. Biol. Chem. 2004) 3 4 23
  3. Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. (PMID: 17210646) Lan H.-C. … Chung B.-C. (Mol. Cell. Biol. 2007) 3 4 23
  4. Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. (PMID: 16000324) Venables J.P. … Elliott D.J. (Hum. Mol. Genet. 2005) 3 23
  5. Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization. (PMID: 10640824) Nupponen N.N. … Visakorpi T. (Cytogenet. Cell Genet. 1999) 3 23

Products for HIPK3 Gene

  • Addgene plasmids for HIPK3

Sources for HIPK3 Gene

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