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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIPK3 Gene

protein-coding   GIFtS: 57
GCID: GC11P033235

homeodomain interacting protein kinase 3

(Previous name: homeodomain-interacting protein kinase 3 )
 Explore 10 diseases affiliated with
HIPK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HIPK3    

Aliases
for HIPK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeodomain Interacting Protein Kinase 31 2     Androgen Receptor-Interacting Nuclear Protein Kinase2 3
DYRK61 2 3 5     Fas-Interacting Serine/Threonine-Protein Kinase2 3
PKY1 2 3 5     Homolog Of Protein Kinase YAK12 3
FIST31 2 3     ANPK2 3
YAK11 2     FIST2 3
Homeodomain-Interacting Protein Kinase 31 2     EC 2.7.11.13 8

External Ids:    HGNC: 49151   Entrez Gene: 101142   Ensembl: ENSG000001104227   OMIM: 6044245   UniProtKB: Q9H4223   

Export aliases for HIPK3 gene to outside databases

Previous GC identifers: GC11P034811 GC11P033957 GC11P033318 GC11P033272 GC11P033264 GC11P032973


Summaries
for HIPK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: HIPK3_HUMAN, Q9H422
Function: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene
expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation.
Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain
transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression
upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that
synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)

Gene Wiki entry for HIPK3


Genomic Views
for HIPK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIPK3 gene promoter:
         HFH-3   AhR   Sox5   Nkx2-5   Evi-1   CREB   FOXI1   deltaCREB   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HIPK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HIPK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

HIPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIPK3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P033235:  view genomic region     (about GC identifiers)

Start:
 33,278,218 bp from pter      End:
 33,378,569 bp from pter
Size:
 100,352 bases      Orientation:
 plus strand

Proteins
for HIPK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HIPK3_HUMAN, Q9H422 (See protein sequence)
Recommended Name: Homeodomain-interacting protein kinase 3  
Size: 1215 amino acids; 133743 Da
Subunit: Interacts with Nkx1-2. Interacts with FAS and DAXX. Probably part of a complex consisting of HIPK3, FAS and
FADD. Interacts with and stabilizes ligand-bound androgen receptor (AR) (By similarity). Interacts with UBL1/SUMO-1.
Binds to NR5A1/SF1, SPEN/MINT and RUNX2
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: O14632 Q2PBG4 Q2PBG5 Q92632 Q9HAS2
Alternative splicing: 2 isoforms:  Q9H422-1   Q9H422-2   

Explore the universe of human proteins at neXtProt for HIPK3: NX_Q9H422

Post-translational modifications:

  • Autophosphorylated, but autophosphorylation is not required for catalytic activity (By similarity)1
  • May be sumoylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H422

    • 4/12 DME Specific Peptides for HIPK3 (Q9H422) (see all 12)
     ETLNHPF  SDTDEEE  HLLDFPHS  CGLKRKSEE 

    HIPK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001041665.1  NP_005725.3  

    ENSEMBL proteins: 
     ENSP00000431710   ENSP00000304226   ENSP00000368301   ENSP00000433594   ENSP00000398241  

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    Novus Biologicals HIPK3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIPK3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016605PML body IEA--


    HIPK3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HIPK3

    Protein Domains /
    Families
    for HIPK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HIPK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9H422

    ProtoNet protein and cluster: Q9H422

    UniProtKB/Swiss-Prot: HIPK3_HUMAN, Q9H422
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for HIPK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HIPK3_HUMAN, Q9H422
    Function: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene
    expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation.
    Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain
    transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression
    upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that
    synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Genatlas biochemistry entry for HIPK3:
    homeodomain interacting protein kinase 3,highly expressed in heart and muscle tissue,localizing in nuclear
    speckles,corepressor for homeo domain transcription factors,maybe involved in cell cycle regulation,over-expressed in
    multidrugg resistant cell-lines

    Enzyme Number (IUBMB): EC 2.7.11.11 2

    miRNA
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    hsa-miR-520e hsa-miR-3653 hsa-miR-578 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-642b hsa-miR-3174 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: HIPK3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity IDA14766760
    GO:0004674protein serine/threonine kinase activity ISS11034606
    GO:0005515protein binding ----
    GO:0005524ATP binding NAS--


    HIPK3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HIPK3:
     Increased G2M DNA content 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Hipk3):
     no phenotypic analysis 

    HIPK3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HIPK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/50 Interacting proteins for HIPK3 (Q9H4222, 3 ENSP000003042264) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HEYLQ9NQ872, 3, ENSP000003619434MINT-61740 I2D: score=3 STRING: ENSP00000361943
    LIMD1Q9UGP42, 3, ENSP000002733174MINT-61750 I2D: score=3 STRING: ENSP00000273317
    ARRB2P321212, 3MINT-61748 I2D: score=3 
    C1QAP027452, 3MINT-61745 I2D: score=3 
    GORASP1Q9BQQ32, 3MINT-61752 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006468protein phosphorylation IDA14766760
    GO:0006915apoptotic process IEA--
    GO:0009299mRNA transcription IDA17210646
    GO:0018105peptidyl-serine phosphorylation ISS11034606


    HIPK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HIPK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HIPK3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for HIPK3

    2 HMDB Compounds for HIPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    2 Novoseek chemical compound relationships for HIPK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 36.2 2 10961928 (1), 9373137 (1)
    serine 22 2 10961928 (1), 9373137 (1)

    Search CenterWatch for drugs/clinical trials and news about HIPK3 

    Transcripts
    for HIPK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HIPK3 gene (2 alternative transcripts): 
    NM_001048200.1  NM_005734.3  

    Unigene Cluster for HIPK3:

    Homeodomain interacting protein kinase 3
    Hs.201918  [show with all ESTs]
    Unigene Representative Sequence: NM_005734
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525975 ENST00000303296(uc001mul.1) ENST00000379016(uc001mum.1)
    ENST00000531504 ENST00000534262(uc009yjw.1) ENST00000456517(uc009yjv.1)


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    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate HIPK3 (see all 71):
    hsa-miR-520e hsa-miR-3653 hsa-miR-578 hsa-miR-519a hsa-miR-3622b-3p hsa-miR-642b hsa-miR-3174 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: HIPK3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF004849.1 AF305239.1 AK293009.1 AK304063.1 AK315277.1 AY425958.1 Y09306.1 

    6 DOTS entries:

    DT.95162334  DT.213566  DT.40312677  DT.86852349  DT.430672  DT.95162333 

    24/122 AceView cDNA sequences (see all 122):

    AA361465 AA788819 AA555172 BM662067 AI803943 BU508689 BX503224 BE003823 
    AW819916 BM828164 BU674709 AA897698 AA341581 BM820433 BM751730 AA504423 
    AI123918 AF305239 AY425958 BI601253 BP335601 BG573419 AA970704 BX500492 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for HIPK3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                                                                      
    SP2:                                                              -                                       


    ECgene alternative splicing isoforms for HIPK3

    Expression
    for HIPK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCACAAGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HIPK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    BoneZeugopod Long BoneBone
    LimbAutopodLimb
    LimbZeugopodLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIPK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIPK3

    SOURCE GeneReport for Unigene cluster: Hs.201918

    UniProtKB/Swiss-Prot: HIPK3_HUMAN, Q9H422
    Tissue specificity: Overexpressed in multidrug resistant cells. Highly expressed in heart and skeletal muscle, and at
    lower levels in placenta, pancreas, brain, spleen, prostate, thymus, testis, small intestine, colon and leukocytes.
    Not found in liver and lung

        SABiosciences Expression via Pathway-Focused PCR Array including HIPK3: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for HIPK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HIPK3 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HIPK31 homeodomain interacting protein kinase 3 80.56(n)
    81.88(a)    		   421597  NM_001199411.1  NP_001186340.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HIPK36
    		 --
    		 79(a)
    		 1 ↔ 1
    		 1(61643303-61701422)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.105382 Xenopus laevis transcribed sequence with weak similarity more 76.19(n)    BM331714.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hipk3b1 homeodomain interacting protein kinase 3b 66.58(n)
    65.99(a)    		   569156  NM_001080159.2  NP_001073628.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta hipk6
    		 homeodomain interacting protein kinase
    		 29(a)
    		 1 → many
    		 3L(543060-581099)
    worm
    (Caenorhabditis elegans)    		 Secernentea hpk-16
    		 Homeodomain interacting Protein Kinase family memb...
    		 41(a)
    		 1 → many
    		 X(4211686-4217266)


    ENSEMBL Gene Tree for HIPK3 (if available)
    TreeFam Gene Tree for HIPK3 (if available) 

    Paralogs
    for HIPK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIPK3 gene
    DYRK32  DYRK22  DYRK1A2  HIPK12  DYRK42  HIPK42  HIPK22  DYRK1B2  
    2 SIMAP similar genes for HIPK3 using alignment to 2 protein entries:     HIPK3_HUMAN (see all proteins):
    HIPK2    HIPK1

    HIPK3 for paralogs           About GeneDecksing



    Genomic Variants
    for HIPK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1555 NCBI SNPs in HIPK3 are shown (see all 1555)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1417148791,2
    		C,other33374746(+) TTTCTC/G/TATGGA 6 H D Y mis10--------
    rs1879450391,2
    		--33277339(+) TATATC/TGGAAG 2 -- us2k10--------
    rs1175375801,2
    		C,F,--33277345(+) GGAAGC/ACTTTT 2 -- us2k11Minor allele frequency- A:0.02EA 120
    rs1930044621,2
    		--33277664(+) CCTCCC/TAAAGT 2 -- us2k10--------
    rs110322141,2
    		C,F,A,H,--33277688(+) GTGCGG/AGCCAC 2 -- us2k111Minor allele frequency- A:0.32NA WA CSA EA 257
    rs1380891191,2
    		--33277747(+) CTTCCG/TGTTTG 2 -- us2k10--------
    rs23079551,2
    		C,--33277919(+) ATTCCAGAA/-  
                AGAAA     		2 -- us2k15Minor allele frequency- -:0.32EU NA EA CSA 344
    rs106525701,2
    		C--33277925(+) GAAAGAAAG/-  
                GTGTT     		2 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1411328031,2
    		--33277937(+) GTTTCC/TCAAAA 2 -- us2k10--------
    rs1503959041,2
    		--33278198(+) GTAAGC/TTGAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIPK3 (33278218 - 33378569 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HIPK3: --

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIPK3
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    Disorders / Diseases
    for HIPK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HIPK3 for disorders           About GeneDecksing

    OMIM gene information: 604424    OMIM disorders: --

    10 diseases for HIPK3:    About MalaCards
    down syndrome    hypogonadism    t-cell leukemia    prostate carcinoma
    leukemia    prostatitis    schizophrenia    carcinoma
    malaria    alcoholism

    1 Novoseek disease relationship for HIPK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 14766760 (1)

    Human Genome Epidemiology (HuGE) Navigator: HIPK3 (2 documents)

    Export disorders for HIPK3 gene to outside databases

    Publications
    for HIPK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIPK3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with HIPK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1. (PubMed id 9373137)1, 2, 3, 9 Begley D.A.... Abraham I. (1997)
    2. Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. (PubMed id 17210646)1, 2, 9 Lan H.C....Chung B.C. (2007)
    3. JNK regulates HIPK3 expression and promotes resistance to Fas- mediated apoptosis in DU 145 prostate carcinoma cells. (PubMed id 14766760)1, 2, 9 Curtin J.F. and Cotter T.G. (2004)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
    5. Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. (PubMed id 10961991)1, 2 Minty A.... Caput D. (2000)
    6. FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2- terminal kinase activation. (PubMed id 11034606)1, 2 Rochat-Steiner V....Tschopp J. (2000)
    7. Activation of androgen receptor function by a novel nuclear protein kinase. (PubMed id 9725910)1, 2 Moilanen A.-M.... Palvimo J.J. (1998)
    8. Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. (PubMed id 9748262)1, 3 Kim Y.H....Kim Y. (1998)
    9. Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization. (PubMed id 10640824)1, 9 Nupponen N.N. and Visakorpi T. (1999)
    10. Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon. (PubMed id 16000324)1, 9 Venables J.P....Elliott D.J. (2005)

    External Searches for HIPK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing HIPK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10114 HGNC: 4915 AceView: HIPK3 Ensembl:ENSG00000110422 euGenes: HUgn10114
    ECgene: HIPK3 H-InvDB: HIPK3

    Other Databases showing HIPK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HIPK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIPK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HIPK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HIPK3 gene:
    Search GeneIP for patents involving HIPK3

    GeneCards and IP:
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