HIPK2 Gene
protein-coding GIFtS : 62 GCID: GC07 M139246
homeodomain interacting protein kinase 2 homeodomain-interacting protein kinase 2 )
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Aliasesfor HIPK2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Homeodomain Interacting Protein Kinase 2 1 2 Homeodomain-Interacting Protein Kinase 21 2 HHIPk21 EC 2.7.11.13 8 PRO05932
Export aliases for HIPK2 gene to outside databases Previous GC identifers: GC07M137598 GC07M138657 GC07M138671 GC07M138714 GC07M138907 GC07M133556
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Summariesfor HIPK2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for HIPK2 : This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2011) UniProtKB/Swiss-Prot: HIPK2_HUMAN, Q9H2X6 Function : Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosisand regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis Gene Wiki entry for HIPK2
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Genomic Viewsfor HIPK2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000007.13 NC_018918.1 NT_007914.15 NT_007933.15 NT_079596.2 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HIPK2 gene promoter:STAT1 GATA-3 AML1a ATF-2 CUTL1 YY1 GATA-1 GATA-2 c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for HIPK2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q32-q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q32-q34 HIPK2 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M139246: view genomic region
(about GC identifiers )
Start: 139,246,316 bp from pter End:
139,477,577 bp from pter
Size: 231,262 bases Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 138,590,861-138,806,654
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Proteinsfor HIPK2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: HIPK2_HUMAN, Q9H2X6 See
protein sequence )Recommended Name: Size : 1198 amino acids; 130966 DaSubunit : Interacts with CREB1, SIAH1, WSB1, CBX4, TRADD, p53/TP53, TP73, TP63, CREBBP, DAXX, P53DINP1, SKI, SMAD1,SMAD2 and SMAD3, but not SMAD4. Interacts with ATF1, PML, RUNX1, EP300, NKX1-2, NKX2-5, SPN/CD43, UBE2I, HMGA1, CTBP1, AXIN1, NLK, MYB, POU4F1, POU4F2, POU4F3, UBE2I, UBL1 and ZBTB4. Probably part of a complex consisting of p53/TP53, HIPK2 and AXIN1
Subcellular location : Nucleus, PML body. Cytoplasm. Note=Concentrated in PML/POD/ND10 nuclear bodies. Small amounts arecytoplasmic
Miscellaneous : Interesting targets for cancer therapy. HIPK2 deregulation would end up in a multifactorial responseleading to tumor chemoresistance by affecting p53/TP53 activity on one hand and to angiogenesis and cell proliferation by affecting HIF1A activity on the other hand. May provide important insights in the process of tumor progression, and may also serve as the crucial point in the diagnostic and therapeutical aspects of cancer. Tumor treatment may potential be improved by zinc supplementation in combination with chemotherapy to address hypoxia (PubMed:20514025)
Secondary accessions : Q75MR7 Q8WWI4 Q9H2Y1Alternative splicing : 3 isoforms : Q9H2X6-1 Q9H2X6-2 Q9H2X6-3 Explore the universe of human proteins at neXtProt for HIPK2: NX_Q9H2X6 Post-translational modifications:
Phosphorylated on tyrosines (By similarity). Autophosphorylated1 Sumoylated. When conjugated it is directed to nuclear speckles. Desumoylated by SENP1 (By similarity). Sumoylation on Lys-32 is promoted by the E3 SUMO-protein ligase CBX41
Ubiquitinated by FBXO3, WSB1 and SIAH1, leading to rapid proteasome-dependent degradation. The degradation mediated by FBXO3, but not ubiquitination, is prevented in the presence of PML. The degradation mediated by WSB1 and SIAH1 is reversibly reduced upon DNA damage1
Cleaved at Asp-923 and Asp-984 by CASP6 in a p53/TP53-dependent manner. The cleaved form lacks the autoinhibitory C-terminal domain (AID), resulting in a hyperactive kinase, which potentiates p53/TP53 Ser-46 phosphorylation and subsequent activation of the cell death machinery1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9H2X6 4/13 DME Specific Peptides for HIPK2 (Q9H2X6 ) (see all 13 )HIPK2 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts): NP_001106710.1 NP_073577.3 ENSEMBL proteins: ENSP00000385571 ENSP00000413724 ENSP00000343108 Human Recombinant Protein Products: Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing HIPK2 Antibody Products: Assay Products for HIPK2:
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Protein
Domains /for HIPK2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9H2X6 ProtoNet protein and cluster: Q9H2X6
UniProtKB/Swiss-Prot: HIPK2_HUMAN, Q9H2X6 Similarity : Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamilySimilarity : Contains 1 protein kinase domain
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Functionfor HIPK2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: HIPK2_HUMAN, Q9H2X6 Function : Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosisand regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis Catalytic activity : ATP + a protein = ADP + a phosphoproteinInduction : Unstable in unstressed cells but stabilized upon DNA damage. Induced by UV irradiation and other genotoxicagents (adriamycin ADR, cisplatin CDDP, etoposide, IR, roscovitin), thus triggering p53/TP53 apoptotic response. Consistutively negatively regulated by SIAH1 and WSB1 through proteasomal degradation. This negative regulation is impaired upon genotoxic stress. Repressed upon hypoxia (often associated with tumors), through MDM2- (an E3 ubiquitin ligases) mediated proteasomal degradation, thus inactivating p53/TP53 apoptotic response. This hypoxia repression is reversed by zinc. The stabilization mediated by DNA damage requires the damage checkpoint kinases ATM and ATR Enzyme Number (IUBMB): EC 2.7.11.1 1 2
Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): HIPK2 (NM_001113239 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIPK2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HIPK2
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK2
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001102 RNA polymerase II activating transcription factor binding
ISS -- GO:0001105 contributes to RNA polymerase II transcription coactivator activityISS -- GO:0003714 transcription corepressor activity
IDA 12874272 GO:0004672 protein kinase activity
TAS 9748262 GO:0004674 protein serine/threonine kinase activity
ISS --
About GeneDecksing 6 GenomeRNAi human phenotypes for HIPK2 :Animal Models: Hipk2 tm1Hko for HIPK29 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hipk2) :About GeneDecksing
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Pathways & Interactionsfor HIPK2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/10 super-pathways (see all 10 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 DNA Damage 2 Apoptosis and Autophagy 3 Integrated Breast Cancer Pathway 4 C-MYB transcription factor network 5 p53 pathway
Pathway sources See GeneCards unified pathways Show all pathways 1 2 3 4 About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIPK2 5/53 Interacting proteins for HIPK2 (Q9H2X6 2 , 3 via UniProtKB, MINT, STRING, and/or I2D (see all 53 )About this table Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
IEA -- GO:0001654 eye development
ISS -- GO:0006468 protein phosphorylation
-- -- GO:0006915 apoptotic process
-- -- GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
IDA 14647468
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Drugs & Compoundsfor HIPK2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for HIPK2 2 HMDB Compounds for HIPK2 About this table 3 Novoseek chemical compound relationships for HIPK2 gene About this table HIPK2
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Transcriptsfor HIPK2 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for HIPK2 gene (2 alternative transcripts): NM_001113239.2 NM_022740.4 Unigene Cluster for HIPK2:
Homeodomain interacting protein kinase 2 Hs.731417 [show with all ESTs ] Unigene Representative Sequence: NM_022740 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000406875 (uc003vvd.4 uc003vvf.4 ) ENST00000428878 ENST00000342645 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 6 )human mouse rat see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): HIPK2 (NM_001113239 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIPK2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HIPK2
Additional cDNA sequence: AF055019.1 AF207702.1 AF208291.1 AF326592.1 AK074291.1 AL833223.1 BC041926.1 BC043184.2 BC043652.1 BC045719.1 BX538009.1 BX647377.1
20 DOTS entries : DT.100639010 DT.100700872
DT.100747919 DT.92432345 DT.315592 DT.100024982 DT.75187665 DT.440228 DT.100747918 DT.95290799 DT.214719 DT.108674 DT.121056684 DT.99948554 DT.101978410 DT.121056614 DT.121609070 DT.95287717 DT.95359708 DT.101967370 24/425 AceView cDNA sequences (see all 425 ):
BQ229846 AV702066 BE465019 AA453802 BU177127 BM129702 AA722184 BQ227272 Z41889 BM707936 AI868491 BQ421382 BQ083195 BM995735 BI439640 AA364909 CB164608 N23123 H94216 AI288943 BQ014736 AA322936 Z38192 CA848240 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for HIPK2 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 SP1 : - - SP2 : - SP3 :
ECgene alternative splicing isoforms for HIPK2
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Expression for HIPK2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section HIPK2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACGTCGTGTG
About this image HIPK2 expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Kidney S-shaped Body Kidney Expression: Experimental details:
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor W8 (Embryonic Progenitor Cell)
See HIPK2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HIPK2 SOURCE GeneReport for Unigene cluster: Hs.731417 UniProtKB/Swiss-Prot: HIPK2_HUMAN, Q9H2X6 Tissue specificity : Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulatedin several thyroid and breast tumors SABiosciences Expression via Pathway-Focused PCR Arrays including HIPK2 : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK2
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Orthologsfor HIPK2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for HIPK2 gene from 6/19 species (see all 19 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves HIPK21
homeodomain interacting protein kinase 2
84.76(n) 93.95(a)
374138 XM_416335.3 XP_416335.3
lizard Reptilia HIPK26
--
93(a)
1 ↔ 1
5(16675083-16775312)
African clawed frog Amphibia BJ071036.12
--
78.38(n)
BJ071036.1
zebrafish Actinopterygii wufk56d122
Transcribed sequence with weak similarity to protein more
79.37(n)
BG306073.1
fruit fly Insecta CG170903 1
protein amino acid phosphorylation protein3 1
55(a) 3 52.08(n) 1 48.36(a) 1
38070 1 NM_138194.2 1 NP_612038.2 1
worm Secernentea hpk-16
Homeodomain interacting Protein Kinase family memb... 41(a)
1 → many
X(4211686-4217266)
ENSEMBL Gene Tree for HIPK2 (if available)TreeFam Gene Tree for HIPK2 (if available)
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Paralogsfor HIPK2 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for HIPK2 gene DYRK3 2 DYRK2 2 DYRK1A 2 HIPK1 2 DYRK4 2 HIPK3 2 HIPK4 2 DYRK1B 2 9 SIMAP similar genes for HIPK2 using alignment to 4 protein entries: HIPK2_HUMAN (see all proteins ):HIPK1 HIPK4 HIPK3 MAPK14 CDK4 DYRK1A CLK1 CLK2 DYRK4 About GeneDecksing
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Genomic Variantsfor HIPK2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 7 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for HIPK2 (139246316 - 139477577 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for HIPK2: --
SABiosciences Cancer Mutation PCR Assays
1 SABiosciences qBiomarker Copy Number PCR Array containing HIPK2 :
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Disorders
/ Diseasesfor HIPK2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 606868
OMIM disorders : --20/26 (see all 26 ): About MalaCards pilocytic astrocytoma acute myeloid leukemia herpes simplex myeloid leukemia squamous cell carcinoma myelodysplastic syndrome down syndrome astrocytoma duodenitis hematopoiesis cervical cancer leukemia cervicitis colon cancer ovarian cancer colorectal cancer breast cancer hypoxia neuroblastoma retinitis 3 Novoseek disease relationships for HIPK2 gene About this table
Human Genome Epidemiology (HuGE) Navigator: HIPK2 (1 document)Export disorders for HIPK2 gene to outside databases
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Publicationsfor HIPK2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for HIPK2 gene, integrated from 9 sources (see all 151 ):(articles sorted by number of sources associating them with HIPK2) Utopia : connect your pdf to the dynamic
Targeting hypoxia in cancer cells by restoring homeod omain interacting protein-kinase 2 and p53 activity and suppressing HIF-1alpha. (PubMed id 19714248) 1 , 2 , 9(2009) HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)- terminal kinase activation and apoptosis in human hepatoma cells. (PubMed id 14678985) 1 , 2 , 9(2003) How cells switch HIPK2 on and off. (PubMed id 18974774) 1 , 2 , 9(2009) Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. (PubMed id 16253240) 1 , 2 , 9(2005) TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity. (PubMed id 12851404) 1 , 2 , 9(2003) Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. (PubMed id 11925430) 1 , 2 , 9(2002) The human protein kinase HIPK2 phosphorylates and dow nregulates the methyl-binding transcription factor ZBTB4. (PubMed id 19448668) 1 , 2 , 9(2009) Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. (PubMed id 18536714) 1 , 2 , 9(2008) Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth. (PubMed id 19046997) 1 , 2 , 9(2009) PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation. (PubMed id 18809579) 1 , 2 , 9(2008)
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External Searches for HIPK2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing HIPK2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing HIPK2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing HIPK2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for HIPK2 gene: HIPK2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor HIPK2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for HIPK2 OriGene shRNA RFP for HIPK2 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for HIPK2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for HIPK2 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for HIPK2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for HIPK2 OriGene Custom Protein Services for HIPK2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIPK2 Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIPK2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for HIPK2
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HIPK2
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Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
In-situ hybridization
