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Aliases for HIPK1 Gene

Aliases for HIPK1 Gene

  • Homeodomain Interacting Protein Kinase 1 2 3
  • Nuclear Body-Associated Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • Nbak2 3 4
  • Myak 3 4
  • Homeodomain Interacting Protein Kinase 1-Like Protein 3
  • Homeodomain-Interacting Protein Kinase 1 3
  • Nuclear Body Associated Kinase 2b 3
  • KIAA0630 4

External Ids for HIPK1 Gene

Previous GeneCards Identifiers for HIPK1 Gene

  • GC01P113572
  • GC01P113770
  • GC01P114184
  • GC01P114203
  • GC01P114273
  • GC01P114471
  • GC01P112330

Summaries for HIPK1 Gene

Entrez Gene Summary for HIPK1 Gene

  • The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for HIPK1 Gene

HIPK1 (Homeodomain Interacting Protein Kinase 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and protein serine/threonine kinase activity. An important paralog of this gene is DYRK1B.

UniProtKB/Swiss-Prot for HIPK1 Gene

  • Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

Gene Wiki entry for HIPK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIPK1 Gene

Genomics for HIPK1 Gene

Regulatory Elements for HIPK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIPK1 Gene

Start:
113,929,192 bp from pter
End:
113,977,869 bp from pter
Size:
48,678 bases
Orientation:
Plus strand

Genomic View for HIPK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIPK1 Gene

Proteins for HIPK1 Gene

  • Protein details for HIPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Z02-HIPK1_HUMAN
    Recommended name:
    Homeodomain-interacting protein kinase 1
    Protein Accession:
    Q86Z02
    Secondary Accessions:
    • A6NJ34
    • O75125
    • Q5SQL2
    • Q5SQL4
    • Q5SQL5
    • Q8IYD7
    • Q8NDN5
    • Q8NEB6
    • Q8TBZ1

    Protein attributes for HIPK1 Gene

    Size:
    1210 amino acids
    Molecular mass:
    130843 Da
    Quaternary structure:
    • Interacts with Nkx1-2, Nkx2-5, MYB, PARK7, DAXX and p53/TP53. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis.

    Alternative splice isoforms for HIPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIPK1 Gene

Proteomics data for HIPK1 Gene at MOPED

Post-translational modifications for HIPK1 Gene

  • Autophosphorylated. Phosphorylated and activated by JNK1.
  • Degraded by PARK7 at the protein level
  • Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF in response to stress stimuli, triggering transient translocation from nucleus to cytoplasm.
  • Ubiquitination at Lys421 and Lys543
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains for HIPK1 Gene

Gene Families for HIPK1 Gene

Suggested Antigen Peptide Sequences for HIPK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86Z02

UniProtKB/Swiss-Prot:

HIPK1_HUMAN :
  • Q86Z02
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
genes like me logo Genes that share domains with HIPK1: view

Function for HIPK1 Gene

Molecular function for HIPK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

Enzyme Numbers (IUBMB) for HIPK1 Gene

Gene Ontology (GO) - Molecular Function for HIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 12702766
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with HIPK1: view
genes like me logo Genes that share phenotypes with HIPK1: view

Animal Models for HIPK1 Gene

MGI Knock Outs for HIPK1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIPK1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for HIPK1 Gene

Localization for HIPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIPK1 Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in response to stress stimuli via SENP1-mediated desumoylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIPK1 Gene COMPARTMENTS Subcellular localization image for HIPK1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15701637
GO:0005737 cytoplasm IDA 15701637
GO:0016605 PML body IEA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with HIPK1: view

Pathways for HIPK1 Gene

SuperPathways for HIPK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001654 eye development ISS 20579985
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007224 smoothened signaling pathway IEA --
genes like me logo Genes that share ontologies with HIPK1: view

No data available for Pathways by source for HIPK1 Gene

Compounds for HIPK1 Gene

(11) HMDB Compounds for HIPK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Heptadecanoic acid
  • Heptadecanoate
506-12-7

(1) Novoseek inferred chemical compound relationships for HIPK1 Gene

Compound -log(P) Hits PubMed IDs
serine 35.8 1
genes like me logo Genes that share compounds with HIPK1: view

Transcripts for HIPK1 Gene

Unigene Clusters for HIPK1 Gene

Homeodomain interacting protein kinase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIPK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIPK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - -
SP2: - -
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7:
SP8: - -

ExUns: 21a · 21b ^ 22a · 22b
SP1: -
SP2: -
SP3:
SP4: -
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for HIPK1 Gene

GeneLoc Exon Structure for
HIPK1
ECgene alternative splicing isoforms for
HIPK1

Expression for HIPK1 Gene

mRNA expression in normal human tissues for HIPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for HIPK1 Gene

This gene is overexpressed in Pancreas (66.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HIPK1 Gene

SOURCE GeneReport for Unigene cluster for HIPK1 Gene Hs.532363

mRNA Expression by UniProt/SwissProt for HIPK1 Gene

Q86Z02-HIPK1_HUMAN
Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis.
genes like me logo Genes that share expressions with HIPK1: view

Expression partners for HIPK1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HIPK1 Gene

Orthologs for HIPK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIPK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIPK1 35
  • 94.1 (n)
  • 98.51 (a)
HIPK1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIPK1 35
  • 94.82 (n)
  • 98.43 (a)
HIPK1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hipk1 35
  • 92.01 (n)
  • 97.69 (a)
Hipk1 16
Hipk1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HIPK1 35
  • 99.75 (n)
  • 99.83 (a)
HIPK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hipk1 35
  • 91.49 (n)
  • 97.44 (a)
oppossum
(Monodelphis domestica)
Mammalia HIPK1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIPK1 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves HIPK1 35
  • 80.24 (n)
  • 89.84 (a)
HIPK1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIPK1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hipk1 35
  • 76.02 (n)
  • 84.63 (a)
Str.1884 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21248 35
zebrafish
(Danio rerio)
Actinopterygii HIPK1 (1 of 2) 36
  • 57 (a)
OneToMany
HIPK1 (2 of 2) 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hipk 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpk-1 36
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YAK1 36
  • 23 (a)
OneToMany
Species with no ortholog for HIPK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIPK1 Gene

ENSEMBL:
Gene Tree for HIPK1 (if available)
TreeFam:
Gene Tree for HIPK1 (if available)

Paralogs for HIPK1 Gene

Selected SIMAP similar genes for HIPK1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HIPK1: view

Variants for HIPK1 Gene

Sequence variations from dbSNP and Humsavar for HIPK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10108 -- 113,973,708(+) TCTTC(C/T)CAAAG utr-variant-3-prime
rs1217440 -- 113,932,387(-) taaaa(A/T)aaaaa intron-variant
rs1238053 -- 113,934,837(-) aattt(C/T)tacag intron-variant
rs1503832 -- 113,947,067(-) AAGAG(A/G)AGGAC intron-variant
rs1553450 -- 113,948,158(-) TTTAC(C/T)GAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIPK1 Gene

Variant ID Type Subtype PubMed ID
esv23869 CNV Loss 19812545
nsv523196 CNV Loss 19592680

Relevant External Links for HIPK1 Gene

HapMap Linkage Disequilibrium report
HIPK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIPK1 Gene

Disorders for HIPK1 Gene

No disorders were found for HIPK1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HIPK1 Gene

Publications for HIPK1 Gene

  1. Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). (PMID: 12702766) Kondo S. … Thukral S.K. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  2. Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. (PMID: 12529400) Ecsedy J.A. … Leder P. (Mol. Cell. Biol. 2003) 3 4
  3. Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. (PMID: 12968034) Song J.J. … Lee Y.J. (J. Biol. Chem. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. (PMID: 15701637) Li X. … Min W. (J. Biol. Chem. 2005) 3 4

Products for HIPK1 Gene

  • Addgene plasmids for HIPK1

Sources for HIPK1 Gene

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