HIPK1 Gene
protein-coding GIFtS: 55
GCID: GC01P114471
|
|
homeodomain interacting protein kinase 1
| |
Aliases
for HIPK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Homeodomain Interacting Protein Kinase 11 2 | | MGC334461 | | Myak1 2 | | MGC335481 | | Nbak21 2 | | Homeodomain Interacting Protein Kinase 1-Like Protein2 | | KIAA06301 3 | | Homeodomain-Interacting Protein Kinase 12 | | Nuclear Body-Associated Kinase 22 3 | | Nuclear Body Associated Kinase 2b2 | | EC 2.7.11.13 8 | | MYAK3 | | MGC266421 | | NBAK23 |
Export aliases for HIPK1 gene to outside databasesPrevious GC identifers: GC01P113572 GC01P113770 GC01P114184 GC01P114203 GC01P114273 GC01P112330 |
Summaries
for HIPK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIPK1:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylateshomeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors.Alternative splicing results in four transcript variants encoding four distinct isoforms. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02Function: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis.Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXXin response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcriptionfactor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers itstranslocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression andpromoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lensformation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroiddifferentiation. May be involved in malignant squamous cell tumor formation
Gene Wiki entry for HIPK1
|
Genomic Views
for HIPK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIPK1 gene promoter:
E2F-4 Max E2F-3a E2F E2F-1 E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIPK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIPK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.2 Ensembl cytogenetic band: 1p13.2 HGNC cytogenetic band: 1p13.1HIPK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P114471: view genomic region
(about GC identifiers)
Start:
|
114,471,814 bp from pter |
End:
|
114,520,426 bp from pter |
Size:
|
48,613 bases |
Orientation:
|
plus strand |
|
Proteins
for HIPK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02 (See
protein sequence)Recommended Name: Homeodomain-interacting protein kinase 1 Size: 1210 amino acids; 130843 Da
Subunit: Interacts with Nkx1-2, Nkx2-5, MYB, PARK7, DAXX and p53/TP53. Part of a cytoplasmic complex made of HIPK1,DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis
Subcellular location: Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm inresponse to stress stimuli via SENP1-mediated desumoylation
Secondary accessions: A6NJ34 O75125 Q5SQL2 Q5SQL4 Q5SQL5 Q8IYD7 Q8NDN5 Q8NEB6 Q8TBZ1Alternative splicing: 4 isoforms: Q86Z02-1 Q86Z02-2 Q86Z02-3 Q86Z02-4 Explore the universe of human proteins at neXtProt for HIPK1: NX_Q86Z02
Post-translational modifications:
Autophosphorylated. Phosphorylated and activated by JNK11
Degraded by PARK7 at the protein level1
Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF inresponse to stress stimuli, triggering transient translocation from nucleus to cytoplasm1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86Z02
4/13 DME Specific Peptides for HIPK1 (Q86Z02) (see all 13)
HIPK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_689909.2 NP_852003.1 NP_938009.1 NP_938010.1
ENSEMBL proteins: ENSP00000407442 ENSP00000358572 ENSP00000358568 ENSP00000358571 ENSP00000358574 ENSP00000422322 ENSP00000426695 ENSP00000340956 ENSP00000358566 ENSP00000355191 ENSP00000409673 ENSP00000358567 ENSP00000384960
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
HIPK1 for ontologies About GeneDecksing
HIPK1 Antibody Products:
Assay Products for HIPK1: |
Protein
Domains /
Families
for HIPK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIPK1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86Z02ProtoNet protein and cluster: Q86Z02 UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamilySimilarity: Contains 1 protein kinase domain |
Function
for HIPK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02Function: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis.Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXXin response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcriptionfactor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers itstranslocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression andpromoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lensformation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroiddifferentiation. May be involved in malignant squamous cell tumor formationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): HIPK1 (NM_198268) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIPK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
HIPK1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for HIPK1:
Animal Models:
Mouse knock-outs for HIPK1: Hipk1tm1Mak Hipk1tm1Hko
8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hipk1):
HIPK1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HIPK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIPK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/20 Interacting proteins for HIPK1 (Q86Z021, 2, 3 ENSP000003585714) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
HIPK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HIPK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HIPK1 for compounds About GeneDecksing
 Browse Tocris compounds for HIPK1
10/11 HMDB Compounds for HIPK1 (see all 11) About this table
1 Novoseek chemical compound relationship for HIPK1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| serine |
35.8 |
1 |
12702766 (1) |
Search CenterWatch for drugs/clinical trials and news about HIPK1
|
Transcripts
for HIPK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIPK1 gene (4 alternative transcripts): NM_152696.3 NM_181358.2 NM_198268.2 NM_198269.2 Unigene Cluster for HIPK1: Homeodomain interacting protein kinase 1 Hs.532363 [show with all ESTs]Unigene Representative Sequence: NM_19826813 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000426820 ENST00000369559(uc001eel.3) ENST00000369555 ENST00000369558(uc001een.3)
ENST00000369561 ENST00000514621 ENST00000503968 ENST00000340480(uc001eeo.3 uc001eeq.3)
ENST00000369553 ENST00000361587 ENST00000443627(uc001eem.3) ENST00000369554
ENST00000406344(uc001eep.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK1 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): HIPK1 (NM_198268) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIPK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK1 |
Additional cDNA sequence: AB014530.1 AB089957.1 AK122662.1 AK302726.1 AL833829.1 BC028408.1 BC033012.2 BC033339.1 BC036057.1 BC052493.1 13 DOTS entries: DT.416996 DT.101983611 DT.91748538 DT.100037089 DT.100791541 DT.92461559 DT.121355792 DT.121355798 DT.92461517 DT.97788543 DT.75163395 DT.91723577 DT.91883394 24/288 AceView cDNA sequences (see all 288): AA702461 BM711346 CR614463 NM_181358 BC033012 AA263006 F10515 NM_152696 BQ224060 AI339226 AI540790 CN479612 BM312835 CA405819 BM724085 BX508129 AI239443 BM313124 BX109069 AI468683 NM_198268 AA234712 H25850 AK122662
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for HIPK1 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | - | | - | | - | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | - | | - | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 21a | · | 21b | ^ | 22a | · | 22b |
|---|
|
| SP1: | | | - | | | | | | |
| SP2: | | | - | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | - | | | | | | |
| SP5: | | | - | | | | | |
ECgene alternative splicing isoforms for HIPK1
|
Expression
for HIPK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIPK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCAGTACA
About this image
See HIPK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIPK1
SOURCE GeneReport for Unigene cluster: Hs.532363
UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breastcancer cell lines. Isoform 2 is highly expressed in testis
SABiosciences Custom PCR Arrays for HIPK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIPK1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK1 |
Orthologs
for HIPK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HIPK1 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HIPK11 |
homeodomain interacting protein kinase 1 |
80.71(n)
90.26(a) |
|
419880 XM_418007.3 XP_418007.2 |
lizard
(Anolis carolinensis) |
Reptilia |
HIPK16 |
-- |
89(a) |
1 ↔ 1 |
4(129657038-129702113) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.212482 |
Xenopus laevis transcribed sequence |
78.98(n) |
|
BU909085.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:dkey-229p15.26CR318593.36 |
-- |
56(a)50(a) |
1 ↔ many1 ↔ many |
23(36912215-36953693) 11(2630614-2659343) |
fruit fly
(Drosophila melanogaster) |
Insecta |
hipk6 |
homeodomain interacting protein kinase |
32(a) |
1 → many |
3L(543060-581099) |
worm
(Caenorhabditis elegans) |
Secernentea |
hpk-16 |
Homeodomain interacting Protein Kinase family memb... |
41(a) |
1 → many |
X(4211686-4217266) |
ENSEMBL Gene Tree for HIPK1 (if available)
TreeFam Gene Tree for HIPK1 (if available) |
Paralogs
for HIPK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIPK1 gene
- DYRK32 DYRK22 DYRK1A2 DYRK42 HIPK32 HIPK42 HIPK22 DYRK1B2
14 SIMAP similar genes for HIPK1 using alignment to 7 protein entries: HIPK1_HUMAN (see all proteins):HIPK2 HIPK4 HIPK3 DYRK4 MAK DYRK1A
CDK7 DAPK1 MOK PNCK MAPK14 CDK4
CLK1 CLK2
HIPK1 for paralogs About GeneDecksing
|
Genomic Variants
for HIPK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIPK1 (114471814 - 114520426 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for HIPK1
3 CNVs: 2322 3306 64644 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIPK1 |
|
Disorders
/ Diseases
for HIPK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIPK1 for disorders About GeneDecksing
OMIM gene information: 608003
OMIM disorders: --
7  diseases for HIPK1: About MalaCardsdown syndrome hematopoiesis breast cancer hypoxia
retinitis malaria neuronitis
Export disorders for HIPK1 gene to outside databases
|
Publications
for HIPK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIPK1 gene, integrated from 9 sources (see all 34):
(articles sorted by number of sources associating them with HIPK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). (PubMed id 12702766)1, 2, 9 Kondo S.... Thukral S.K. (2003)
- HIPK1 interacts with c-Myb and modulates its activity through phosphorylation. (PubMed id 19646965)1, 2 Matre V....Gabrielsen O.S. (2009)
- DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. (PubMed id 16390825)1, 2 Sekito A....Ariga H. (2006)
- Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. (PubMed id 15701637)1, 2 Li X....Min W. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. (PubMed id 12968034)1, 2 Song J.J. and Lee Y.J. (2003)
- Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. (PubMed id 12529400)1, 2 Ecsedy J.A.... Leder P. (2003)
- Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
- Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. (PubMed id 22173032)1 Lee D....Choi C.Y. (2012)
- Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
|
External Searches for HIPK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIPK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIPK1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing HIPK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for HIPK1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for HIPK1 gene:
Search GeneIP for patents involving HIPK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HIPK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HIPK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIPK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIPK1 | | | OriGene Protein Over-expression Lysate for HIPK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIPK1 | | OriGene 3'-UTR Clone for HIPK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIPK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIPK1 | | OriGene Custom Protein Services for HIPK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIPK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIPK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIPK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIPK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIPK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIPK1 |
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| | | | Search Tocris compounds for HIPK1 |
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 | | | HIPK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HIPK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK1 |
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