Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIPK1 Gene

protein-coding   GIFtS: 59
GCID: GC01P114471

Homeodomain Interacting Protein Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Homeodomain Interacting Protein Kinase 11 2     Homeodomain-Interacting Protein Kinase 12
Nuclear Body-Associated Kinase 22 3     Nuclear Body Associated Kinase 2b2
EC 2.7.11.13 8     KIAA06303
Myak2     MYAK3
Nbak22     NBAK23
Homeodomain Interacting Protein Kinase 1-Like Protein2     

External Ids:    HGNC: 190061   Entrez Gene: 2048512   Ensembl: ENSG000001633497   OMIM: 6080035   UniProtKB: Q86Z023   

Export aliases for HIPK1 gene to outside databases

Previous GC identifers: GC01P113572 GC01P113770 GC01P114184 GC01P114203 GC01P114273 GC01P112330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HIPK1 Gene:
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It
phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain
transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HIPK1 Gene:
HIPK1 (homeodomain interacting protein kinase 1) is a protein-coding gene. Diseases associated with HIPK1 include down syndrome, and hypoxia. GO annotations related to this gene include protein serine/threonine kinase activity and identical protein binding. An important paralog of this gene is DYRK1A.

UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02
Function: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular
apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB.
Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm.
Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence
of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear
MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved
in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes
angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor
formation

Gene Wiki entry for HIPK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIPK1 gene promoter:
         E2F-4   Max   E2F-3a   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIPK1 promoter sequence
   Search Chromatin IP Primers for HIPK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIPK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.2   Ensembl cytogenetic band:  1p13.2   HGNC cytogenetic band: 1p13.1

HIPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIPK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P114471:  view genomic region     (about GC identifiers)

Start:
114,471,814 bp from pter      End:
114,520,491 bp from pter
Size:
48,678 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02 (See protein sequence)
Recommended Name: Homeodomain-interacting protein kinase 1  
Size: 1210 amino acids; 130843 Da
Subunit: Interacts with Nkx1-2, Nkx2-5, MYB, PARK7, DAXX and p53/TP53. Part of a cytoplasmic complex made of
HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent
apoptosis
Secondary accessions: A6NJ34 O75125 Q5SQL2 Q5SQL4 Q5SQL5 Q8IYD7 Q8NDN5 Q8NEB6 Q8TBZ1
Alternative splicing: 4 isoforms:  Q86Z02-1   Q86Z02-2   Q86Z02-3   Q86Z02-4   

Explore the universe of human proteins at neXtProt for HIPK1: NX_Q86Z02

Explore proteomics data for HIPK1 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylated and activated by JNK11
  • Degraded by PARK7 at the protein level1
  • Sumoylated. When conjugated it is directed to nuclear speckles. SENP1-mediated desumoylation is mediated by TNF in
    response to stress stimuli, triggering transient translocation from nucleus to cytoplasm1
  • Ubiquitination2 at Lys421, Lys543
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for HIPK1 (Q86Z02) (see all 13)
     SILSRLS  SDTDEEE  LNYQSALY  HLLDFPHS 


    See HIPK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_689909.2  NP_852003.1  NP_938009.1  NP_938010.1  

    ENSEMBL proteins: 
     ENSP00000407442   ENSP00000358572   ENSP00000358571   ENSP00000358574   ENSP00000358568  
     ENSP00000422322   ENSP00000426695   ENSP00000340956   ENSP00000358566   ENSP00000355191  
     ENSP00000358567   ENSP00000384960  

    HIPK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant HIPK1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HIPK1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HIPK1
    GenScript Custom Purified and Recombinant Proteins Services for HIPK1
    Novus Biologicals HIPK1 Proteins
    Novus Biologicals HIPK1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIPK1

    HIPK1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for HIPK1
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIPK1
    Novus Biologicals HIPK1 Antibodies
    Abcam antibodies for HIPK1
    Cloud-Clone Corp. Antibodies for HIPK1
    ThermoFisher Antibodies for HIPK1
    LSBio Antibodies in human, mouse, rat for HIPK1

    HIPK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIPK1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIPK1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIPK1
    Cloud-Clone Corp. CLIAs for HIPK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: homeodomain interacting protein kinase 1
    HIPK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q86Z02

    ProtoNet protein and cluster: Q86Z02

    UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02
    Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily
    Similarity: Contains 1 protein kinase domain


    HIPK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HIPK1_HUMAN, Q86Z02
    Function: Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular
    apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB.
    Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm.
    Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence
    of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear
    MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved
    in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes
    angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor
    formation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Number (IUBMB): EC 2.7.11.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI12702766
    GO:0005524ATP binding IEA--
         
    HIPK1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HIPK1:
     Decreased CYP1A1 activity afte  Decreased focal adhesion (FA)   Decreased substrate adherent c 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hipk1):
     cellular  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system  tumorigenesis  vision/eye 

    HIPK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HIPK1: Hipk1tm1Mak Hipk1tm1Hko

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIPK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIPK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIPK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIPK1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIPK1:
    hsa-mir-26b-5p (MIRT029031), hsa-mir-590-3p (MIRT016192), hsa-mir-484 (MIRT041890), hsa-mir-19b-3p (MIRT031114), hsa-mir-877-3p (MIRT036950), hsa-mir-615-3p (MIRT040363), hsa-mir-92a-3p (MIRT049450), hsa-mir-1260b (MIRT052695), hsa-let-7b-5p (MIRT052071), hsa-let-7e-5p (MIRT051518)

    Block miRNA regulation of human, mouse, rat HIPK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIPK1 (see all 94):
    hsa-miR-194* hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-300 hsa-miR-200a hsa-miR-30d hsa-miR-30a hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIPK1
    Predesigned siRNA for gene silencing in human, mouse, rat HIPK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIPK1

    Clone
    Products:
         
    OriGene clones in human, mouse for HIPK1 (see all 21)
    OriGene ORF clones in mouse, rat for HIPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HIPK1 (NM_198268)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIPK1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIPK1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HIPK1_HUMAN, Q86Z02: Nucleus. Cytoplasm. Note=Predominantly nuclear. Translocates from nucleus to cytoplasm in
    response to stress stimuli via SENP1-mediated desumoylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15701637
    GO:0005737cytoplasm IDA15701637
    GO:0016605PML body IEA--
    GO:0016607nuclear speck IEA--

    HIPK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIPK1
    Interactions:

        GeneGlobe Interaction Network for HIPK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIPK1 (Q86Z021, 2, 3 ENSP000003585714) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 3, ENSP000002693054EBI-692891,EBI-366083 I2D: score=4 STRING: ENSP00000269305
    SNIP1Q8TAD82, 3MINT-62163 I2D: score=3 
    PRPF40AO754002, 3MINT-61870 I2D: score=2 
    DAXXQ9UER73, ENSP000003968764I2D: score=5 STRING: ENSP00000396876 STRING: ENSP00000266000
    ENSG00000206206Q9UER73I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001654eye development ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0006468protein phosphorylation ----
    GO:0007224smoothened signaling pathway IEA--

    HIPK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIPK1

    Selected HMDB Compounds for HIPK1 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--
    Pentadecanoic acidPentadecanoate (see all 8)1002-84-2--
    Stearic acid1-Heptadecanecarboxylate (see all 12)57-11-4--

    1 Novoseek inferred chemical compound relationship for HIPK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    serine 35.8 1 12702766 (1)



    HIPK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIPK1 gene (4 alternative transcripts): 
    NM_152696.3  NM_181358.2  NM_198268.2  NM_198269.2  

    Unigene Cluster for HIPK1:

    Homeodomain interacting protein kinase 1
    Hs.532363  [show with all ESTs]
    Unigene Representative Sequence: NM_198268
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000426820 ENST00000369559(uc001eel.3) ENST00000369558(uc001een.3)
    ENST00000369561 ENST00000369555 ENST00000514621 ENST00000503968 ENST00000340480(uc001eeo.3 uc001eeq.3)
    ENST00000369553 ENST00000361587 ENST00000369554 ENST00000406344(uc001eep.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIPK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIPK1 (see all 94):
    hsa-miR-194* hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-300 hsa-miR-200a hsa-miR-30d hsa-miR-30a hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIPK1
    Predesigned siRNA for gene silencing in human, mouse, rat HIPK1
    Clone
    Products:
         
    OriGene clones in human, mouse for HIPK1 (see all 21)
    OriGene ORF clones in mouse, rat for HIPK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HIPK1 (NM_198268)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIPK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HIPK1
    OriGene qSTAR qPCR primer pairs in human, mouse for HIPK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIPK1
      QuantiTect SYBR Green Assays in human, mouse, rat HIPK1
      QuantiFast Probe-based Assays in human, mouse, rat HIPK1

    Additional mRNA sequence: 

    AB014530.1 AB089957.1 AK122662.1 AK302726.1 AL833829.1 BC028408.1 BC033012.2 BC033339.1 
    BC036057.1 BC052493.1 

    13 DOTS entries:

    DT.416996  DT.101983611  DT.91748538  DT.100037089  DT.100791541  DT.92461559  DT.121355792  DT.121355798 
    DT.92461517  DT.97788543  DT.75163395  DT.91723577  DT.91883394 

    Selected AceView cDNA sequences (see all 288):

    AI354680 AI066537 AB014530 AI540790 AB089957 CA405819 BX508129 CF529310 
    CN479612 AI675973 AA644272 BM313124 BE349211 AA654175 F12911 NM_198268 
    BQ224060 H25850 AI685006 AI868928 AI339226 AW044423 AI954823 BQ007141 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HIPK1 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
    SP1:              -     -     -                       -           -     -                                                                                       
    SP2:                                                              -     -                                                                                       
    SP3:        -     -     -     -                       -           -     -                                                                                       
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21a · 21b ^ 22a · 22b
    SP1:        -               
    SP2:        -               
    SP3:                        
    SP4:        -               
    SP5:        -               


    ECgene alternative splicing isoforms for HIPK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIPK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCAGTACA
    HIPK1 Expression
    About this image


    HIPK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    HIPK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIPK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532363

    UniProtKB/Swiss-Prot: HIPK1_HUMAN, Q86Z02
    Tissue specificity: Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in
    breast cancer cell lines. Isoform 2 is highly expressed in testis

        Custom PCR Arrays for HIPK1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HIPK1
    OriGene qSTAR qPCR primer pairs in human, mouse for HIPK1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIPK1
    QuantiTect SYBR Green Assays in human, mouse, rat HIPK1
    QuantiFast Probe-based Assays in human, mouse, rat HIPK1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for HIPK1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hipk11 , 5 homeodomain interacting protein kinase 11, 5 92.01(n)1
    97.69(a)1
      3 (45.52 cM)5
    152571  NM_010432.21  NP_034562.21 
     1037398155 
    chicken
    (Gallus gallus)
    Aves HIPK11 homeodomain interacting protein kinase 1 80.24(n)
    89.84(a)
      419880  XM_418007.4  XP_418007.3 
    lizard
    (Anolis carolinensis)
    Reptilia HIPK16
    homeodomain interacting protein kinase 1
    75(a)
    1 ↔ 1
    4(129646631-129702113)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.212482 Xenopus laevis transcribed sequence 78.98(n)    BU909085.1 
    zebrafish
    (Danio rerio)
    Actinopterygii HIPK1 (1 of 2)6
    HIPK1 (2 of 2)6
    homeodomain interacting protein kinase 1
    57(a)
    51(a)
    1 ↔ many
    1 ↔ many
    23(36912215-36953693) ENSDARG00000063594
    11(2630614-2659343) ENSDARG00000077095
    fruit fly
    (Drosophila melanogaster)
    Insecta hipk6
    homeodomain interacting protein kinase
    33(a)
    1 → many
    3L(543060-581099)
    worm
    (Caenorhabditis elegans)
    Secernentea hpk-16
    Protein HPK-1, isoform c (hpk-1) mRNA, complete cd...
    41(a)
    1 → many
    X(4210654-4217290) WBGene00001994
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YAK16
    Serine-threonine protein kinase; component of a gl...
    23(a)
    1 → many
    X(147967-150390) YJL141C


    ENSEMBL Gene Tree for HIPK1 (if available)
    TreeFam Gene Tree for HIPK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIPK1 gene
    DYRK1A2  DYRK22  DYRK32  ENSG000002729212  DYRK42  HIPK32  HIPK42  HIPK22  
    DYRK1B2  
    12 SIMAP similar genes for HIPK1 using alignment to 6 protein entries:     HIPK1_HUMAN (see all proteins):
    HIPK2    HIPK4    DYRK4    HIPK3    MAK    DYRK1A
    CDK7    DAPK1    MAPK14    MOK    PNCK    CDK4

    HIPK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HIPK1 (see all 946)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833518291,2
    --114470005(+) TGGAGC/TGCAAT 2 -- us2k10--------
    rs1154356971,2
    F--114470022(+) ATCTCG/AGCTCA 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1872052461,2
    --114470056(+) CCAGCA/GGTTCT 2 -- us2k10--------
    rs1921205041,2
    --114470212(+) CCTCCC/TGAAGT 2 -- us2k10--------
    rs766216591,2
    F--114470323(+) ATGACT/AAAACT 2 -- us2k11Minor allele frequency- A:0.02NA 120
    rs1145643971,2
    C,F--114470439(+) CTGTAA/GGGTCC 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1853198401,2
    --114470594(+) AAGAAA/GCTCTC 2 -- us2k10--------
    rs1882475101,2
    --114470919(+) TTCTGA/GCTCAT 2 -- us2k10--------
    rs1927604371,2
    --114470979(+) GCCCAA/GTGTGA 2 -- us2k10--------
    rs1507362191,2
    --114470993(+) CTTTAA/GGTAGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIPK1 (114471814 - 114520491 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIPK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv23869CNV Loss19812545
    nsv523196CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIPK1
    DNA2.0 Custom Variant and Variant Library Synthesis for HIPK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608003    OMIM disorders: --

    6 diseases for HIPK1:    
    About MalaCards
    down syndrome    hypoxia    retinitis    endotheliitis
    breast cancer    neuronitis


    HIPK1 for disorders           About GeneDecksing


    Export disorders for HIPK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIPK1 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with HIPK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). (PubMed id 12702766)1, 2, 9 Kondo S.... Thukral S.K. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. HIPK1 interacts with c-Myb and modulates its activity through phosphorylation. (PubMed id 19646965)1, 2 Matre V....Gabrielsen O.S. (Biochem. Biophys. Res. Commun. 2009)
    3. DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. (PubMed id 16390825)1, 2 Sekito A....Ariga H. (Free Radic. Res. 2006)
    4. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. (PubMed id 15701637)1, 2 Li X.... Min W. (J. Biol. Chem. 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. (PubMed id 12968034)1, 2 Song J.J. and Lee Y.J. (J. Biol. Chem. 2003)
    7. Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. (PubMed id 12529400)1, 2 Ecsedy J.A.... Leder P. (Mol. Cell. Biol. 2003)
    8. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1998)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 204851 HGNC: 19006 AceView: HIPK1 Ensembl:ENSG00000163349 euGenes: HUgn204851
    ECgene: HIPK1 H-InvDB: HIPK1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0630

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIPK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIPK1 gene:
    Search GeneIP for patents involving HIPK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant HIPK1 Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for HIPK1 (HIPK1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HIPK1  
     OriGene qPCR primer pairs and template standards for HIPK1   OriGene Protein Over-expression Lysate for HIPK1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HIPK1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIPK1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HIPK1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIPK1   OriGene Custom Protein Services for HIPK1  

     
     
     Block miRNA regulation of human, mouse, rat HIPK1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIPK1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIPK1 Predesigned siRNA for gene silencing in human, mouse, rat HIPK1
     QuantiFast Probe-based Assays in human, mouse, rat HIPK1 QuantiTect SYBR Green Assays in human, mouse, rat HIPK1
     Custom PCR Arrays for HIPK1 Search Chromatin IP Primers for HIPK1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIPK1  GeneGlobe Interaction Network for HIPK1
     Regulatory tfbs in HIPK1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIPK1 GenScript cDNA clones with any tag delivered in your preferred vector for HIPK1
     GenScript Custom Assay Services for HIPK1 GenScript Custom overexpressing Cell Line Services for HIPK1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HIPK1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HIPK1 antibodies
     HIPK1 proteins
     HIPK1 lysates
     Antibodies for HIPK1
     See all of Abcam's Antibodies, Kits and Proteins for HIPK1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HIPK1
     Antibodies for HIPK1
     ELISAs for HIPK1
     CLIAs for HIPK1



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIPK1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIPK1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIPK1
     SwitchGear Promoter luciferase reporter plasmids for HIPK1
     ThermoFisher Antibodies for HIPK1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIPK1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIPK1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIPK1
     LSBio Antibodies in human, mouse, rat for HIPK1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIPK1 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4