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Aliases for HIP1R Gene

Aliases for HIP1R Gene

  • Huntingtin Interacting Protein 1 Related 2 3
  • HIP12 3 4 6
  • Huntingtin-Interacting Protein 12 3 4
  • HIP1-Related Protein 3 4
  • HIP-12 3 4
  • Huntingtin-Interacting Protein 1-Related Protein 3
  • Huntingtin Interacting Protein 12 3
  • KIAA0655 4
  • ILWEQ 3
  • HIP3 3

External Ids for HIP1R Gene

Previous GeneCards Identifiers for HIP1R Gene

  • GC12P122029
  • GC12M122922
  • GC12P123127
  • GC12P121757
  • GC12P121844
  • GC12P123319
  • GC07M021782

Summaries for HIP1R Gene

GeneCards Summary for HIP1R Gene

HIP1R (Huntingtin Interacting Protein 1 Related) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include actin binding and phosphatidylinositol binding. An important paralog of this gene is HIP1.

UniProtKB/Swiss-Prot for HIP1R Gene

  • Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.

Gene Wiki entry for HIP1R Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIP1R Gene

Genomics for HIP1R Gene

Regulatory Elements for HIP1R Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIP1R Gene

122,834,453 bp from pter
122,862,961 bp from pter
28,509 bases
Plus strand

Genomic View for HIP1R Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIP1R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIP1R Gene

Proteins for HIP1R Gene

  • Protein details for HIP1R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Huntingtin-interacting protein 1-related protein
    Protein Accession:
    Secondary Accessions:
    • A6NHQ6
    • Q6NXG8
    • Q9UED9

    Protein attributes for HIP1R Gene

    1068 amino acids
    Molecular mass:
    119388 Da
    Quaternary structure:
    • Interacts with actin. Does not interact with huntingtin (By similarity). Interacts with CLTB and HIP1. Homodimer. Homodimerization promotes actin binding.
    • Sequence=BAA31630.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HIP1R Gene

    Alternative splice isoforms for HIP1R Gene


neXtProt entry for HIP1R Gene

Proteomics data for HIP1R Gene at MOPED

Post-translational modifications for HIP1R Gene

  • Ubiquitination at Lys146
  • Modification sites at PhosphoSitePlus

Other Protein References for HIP1R Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIP1R Gene

Domains for HIP1R Gene

Suggested Antigen Peptide Sequences for HIP1R Gene

Graphical View of Domain Structure for InterPro Entry



  • O75146
  • Binds F-actin via the talin-like I/LWEQ domain
  • Contains 1 ENTH (epsin N-terminal homology) domain.
  • Contains 1 I/LWEQ domain.
  • Belongs to the SLA2 family.
genes like me logo Genes that share domains with HIP1R: view

No data available for Gene Families for HIP1R Gene

Function for HIP1R Gene

Molecular function for HIP1R Gene

GENATLAS Biochemistry:
Huntingtin interacting protein 1 related,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.

Gene Ontology (GO) - Molecular Function for HIP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 11889126
GO:0005543 phospholipid binding --
GO:0030276 clathrin binding IEA --
GO:0035091 phosphatidylinositol binding IDA 14732715
genes like me logo Genes that share ontologies with HIP1R: view

Phenotypes for HIP1R Gene

MGI mutant phenotypes for HIP1R:
inferred from 1 alleles
GenomeRNAi human phenotypes for HIP1R:
genes like me logo Genes that share phenotypes with HIP1R: view

Animal Models for HIP1R Gene

MGI Knock Outs for HIP1R:

Animal Model Products

miRNA for HIP1R Gene

miRTarBase miRNAs that target HIP1R

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HIP1R Gene

Localization for HIP1R Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIP1R Gene

Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.

Subcellular locations from

Jensen Localization Image for HIP1R Gene COMPARTMENTS Subcellular localization image for HIP1R gene
Compartment Confidence
cytosol 3
plasma membrane 3
cytoskeleton 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HIP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0005905 coated pit IEA --
GO:0016020 membrane --
GO:0030136 clathrin-coated vesicle IDA 11889126
genes like me logo Genes that share ontologies with HIP1R: view

Pathways for HIP1R Gene

genes like me logo Genes that share pathways with HIP1R: view

Gene Ontology (GO) - Biological Process for HIP1R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IMP 11889126
GO:0006915 apoptotic process IEA --
GO:0072583 clathrin-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with HIP1R: view

Compounds for HIP1R Gene

(1) Novoseek inferred chemical compound relationships for HIP1R Gene

Compound -log(P) Hits PubMed IDs
inositol 49.6 3
genes like me logo Genes that share compounds with HIP1R: view

Transcripts for HIP1R Gene

mRNA/cDNA for HIP1R Gene

(11) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIP1R Gene

Huntingtin interacting protein 1 related:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIP1R

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIP1R Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21 ^
SP1: - - -
SP2: -
SP3: - -

ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33a · 33b · 33c ^ 34
SP3: -
SP4: -
SP7: - - -

Relevant External Links for HIP1R Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIP1R Gene

mRNA expression in normal human tissues for HIP1R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for HIP1R Gene

This gene is overexpressed in Brain (12.8), Islet of Langerhans (7.1), and Salivary gland (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIP1R Gene

SOURCE GeneReport for Unigene cluster for HIP1R Gene Hs.524815

mRNA Expression by UniProt/SwissProt for HIP1R Gene

Tissue specificity: Brain, heart, kidney, pancreas, and liver, but not in lung or placenta
genes like me logo Genes that share expressions with HIP1R: view

Expression partners for HIP1R Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HIP1R Gene

Orthologs for HIP1R Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIP1R Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HIP1R 35
  • 89.12 (n)
  • 91.37 (a)
HIP1R 36
  • 90 (a)
(Canis familiaris)
Mammalia HIP1R 35
  • 87.91 (n)
  • 89.49 (a)
HIP1R 36
  • 88 (a)
(Mus musculus)
Mammalia Hip1r 35
  • 86.89 (n)
  • 90.92 (a)
Hip1r 16
Hip1r 36
  • 91 (a)
(Pan troglodytes)
Mammalia HIP1R 35
  • 98.37 (n)
  • 97.83 (a)
HIP1R 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Hip1r 35
  • 87.08 (n)
  • 91.95 (a)
(Monodelphis domestica)
Mammalia HIP1R 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia HIP1R 36
  • 82 (a)
(Gallus gallus)
Aves HIP1R 35
  • 77.63 (n)
  • 78.69 (a)
HIP1R 36
  • 79 (a)
(Anolis carolinensis)
Reptilia HIP1R 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hip1r 35
  • 67.39 (n)
  • 72.27 (a)
Str.16702 35
(Danio rerio)
Actinopterygii hip1rb 35
  • 64.31 (n)
  • 63.25 (a)
HIP1R (2 of 2) 36
  • 45 (a)
hip1rb 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hip1 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea tag-138 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLA2 36
  • 21 (a)
SLA2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
-- 36
  • 56 (a)
Species with no ortholog for HIP1R:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIP1R Gene

Gene Tree for HIP1R (if available)
Gene Tree for HIP1R (if available)

Paralogs for HIP1R Gene

Paralogs for HIP1R Gene

Selected SIMAP similar genes for HIP1R Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HIP1R: view

Variants for HIP1R Gene

Sequence variations from dbSNP and Humsavar for HIP1R Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs735378 -- 122,841,021(+) TTAAA(A/G)TGGAA intron-variant
rs748687 -- 122,839,892(+) CAGCC(C/T)GCACC intron-variant
rs754080 -- 122,840,749(-) GTCCC(C/T)ACCTG intron-variant
rs897384 -- 122,846,797(-) GAGCT(A/G)GGGGA intron-variant
rs897385 -- 122,856,750(-) CCACC(C/T)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIP1R Gene

Variant ID Type Subtype PubMed ID
nsv899571 CNV Loss 21882294
dgv1497n71 CNV Loss 21882294
nsv517200 CNV Loss 19592680
dgv1498n71 CNV Loss 21882294
esv2746501 CNV Deletion 23290073
nsv52669 CNV Loss 16902084
esv1005186 CNV Deletion 20482838
esv1123331 CNV Deletion 17803354
nsv52581 CNV Loss 16902084
nsv7239 OTHER Inversion 18451855

Relevant External Links for HIP1R Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIP1R Gene

Disorders for HIP1R Gene

Relevant External Links for HIP1R

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HIP1R Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HIP1R Gene

Publications for HIP1R Gene

  1. Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. (PMID: 15533940) Chen C.-Y. … Brodsky F.M. (J. Biol. Chem. 2005) 3 4 23
  2. Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1). (PMID: 9852681) Seki N. … Saito T. (J. Hum. Genet. 1998) 3 4 23
  3. HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3- phosphoinositides via epsin N-terminal homology domains. (PMID: 14732715) Hyun T.S. … Ross T.S. (J. Biol. Chem. 2004) 3 4 23
  4. Structural definition of the F-actin-binding THATCH domain from HIP1R. (PMID: 16415883) Brett T.J. … Fremont D.H. (Nat. Struct. Mol. Biol. 2006) 2 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for HIP1R Gene

Sources for HIP1R Gene

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