HIP1 Gene
protein-coding GIFtS: 62
GCID: GC07M075162
|
|
huntingtin interacting protein 1
| |
Aliases
for HIP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Huntingtin Interacting Protein 11 2 | | ILWEQ1 2 | | Huntingtin-Interacting Protein I2 3 | | HIP-I2 3 | | Huntingtin-Interacting Protein 12 | | HIP-13 |
Export aliases for HIP1 gene to outside databasesPrevious GC identifers: GC07M073699 GC07M074762 GC07M074776 GC07M074777 GC07M074808 GC07M075001 GC07M070249 |
Summaries
for HIP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIP1:
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein hassimilarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in thecell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect inmembrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function ofhuntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis ofhematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene.(provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291Function: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptortrafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediatedtranscription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosispathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival bystabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cellfilament networks. May be required for differentiation, proliferation, and/or survival of somatic and germlineprogenitors
|
Genomic Views
for HIP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079595.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIP1 gene promoter:
AML1a Tal-1 AP-2alpha isoform 3 AP-4 AP-2alpha isoform 2 AP-2gamma E47 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q11.23 Ensembl cytogenetic band: 7q11.23 HGNC cytogenetic band: 7q11.23HIP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M075162: view genomic region
(about GC identifiers)
Start:
|
75,162,621 bp from pter |
End:
|
75,368,280 bp from pter |
Size:
|
205,660 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 74,496,473-74,701,343 |
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Proteins
for HIP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291 (See
protein sequence)Recommended Name: Huntingtin-interacting protein 1 Size: 1037 amino acids; 116221 Da
Subunit: Homodimer. Binds actin. Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds toIFT57. In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT. However, inmutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting theinteraction between HIP1 and IFT57. Interacts with CLTB (via N-terminus). Interacts (via coiled coil domain) with AR.Interacts with AP2A1, AP2A2, CLTC and HIP1R. Interacts with GRIA1, GRIN2A AND GRIN2B
Subcellular location: Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane.Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR
Miscellaneous: The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of thepolyglutamine tract added to the huntingtin protein in Huntington disease
Sequence caution: Sequence=AAC51257.1; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for HIP1:2NO2 (3D)
2QA7 (3D)
3I00 (3D)
Secondary accessions: B4E3I7 E7ES17 O00328 Q2TB58 Q8TDL4Alternative splicing: 3 isoforms: O00291-1 O00291-2 O00291-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HIP1: NX_O00291
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00291
HIP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001230127.1 NP_005329.3
ENSEMBL proteins: ENSP00000336747 ENSP00000410300 ENSP00000414280
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
HIP1 for ontologies About GeneDecksing
HIP1 Antibody Products:
Assay Products for HIP1: |
Protein
Domains /
Families
for HIP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIP1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00291ProtoNet protein and cluster: O00291 3 Blocks protein families: IPB001026 Epsin N-terminal homology IPB002558 I/LWEQ domain IPB013809 Epsin-like
UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291Domain: The pseudo DED region (pDED) mediates the interaction with IFT57Domain: Binds F-actin via the talin-like I/LWEQ domainSimilarity: Belongs to the SLA2 familySimilarity: Contains 1 ENTH (epsin N-terminal homology) domainSimilarity: Contains 1 I/LWEQ domain |
Function
for HIP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291Function: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptortrafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediatedtranscription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosispathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival bystabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cellfilament networks. May be required for differentiation, proliferation, and/or survival of somatic and germlineprogenitors Genatlas biochemistry entry for HIP1:huntingtin interacting protein,116kDa,expressed in neurons of the central nervous system,homolog to S.cerevisaeSPa2p,putatively involved in neuronal cytoskeleton function
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HIP1 (NM_005338) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIP1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
HIP1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for HIP1: Hip1tm3Tsr Hip1tm2.1Tsr Hip1tm1Tsr
15/17 MGI mutant phenotypes (inferred from 6 alleles ) (MGI details for Hip1) (see all 17):
HIP1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HIP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Clathrin-dependent protein traffic | | | 2 | EGFR1 Signaling Pathway | | | 3 | Coregulation of Androgen receptor activity | | | 4 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 5 | CCR3 Pathway in Eosinophils | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for HIP1
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HIP1
2  GeneGo (Thomson Reuters) Pathways for HIP1
2  BioSystems Pathways for HIP1
1 
Kegg Pathway (Kegg details for HIP1):
HIP1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIP1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/42 Interacting proteins for HIP1 (O002912, 3 ENSP000003367474) via UniProtKB, MINT, STRING, and/or I2D (see all 42)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
HIP1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HIP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HIP1 for compounds About GeneDecksing
 Browse Tocris compounds for HIP1
5 Novoseek chemical compound relationships for HIP1 gene About this table
Search CenterWatch for drugs/clinical trials and news about HIP1
|
Transcripts
for HIP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIP1 gene (2 alternative transcripts): NM_001243198.1 NM_005338.5 Unigene Cluster for HIP1: Huntingtin interacting protein 1 Hs.329266 [show with all ESTs]Unigene Representative Sequence: NM_0053386 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000336926(uc003uds.2 uc011kfz.2) ENST00000434438 ENST00000404944
ENST00000420909 ENST00000485723 ENST00000479835
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIP1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIP1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HIP1 (NM_005338) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIP1 |
Additional cDNA sequence: AF365404.1 AF486833.1 AK296390.1 AK302382.1 AK304738.1 BC082970.1 BC110545.2 BC139786.1 U79734.1 Y09420.1 11 DOTS entries: DT.409985 DT.95162272 DT.100658614 DT.70102239 DT.75195481 DT.97858552 DT.91735869 DT.121061226 DT.40118954 DT.75163476 DT.99936096 6 AceView cDNA sequences: AI272229 CA427404 CA442592 BM990826 N33381 BQ690764
GeneLoc Exon Structure
|
Expression
for HIP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTCAGGT
About this image
See HIP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIP1
SOURCE GeneReport for Unigene cluster: Hs.329266
UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291Tissue specificity: Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate andcolon cancer
SABiosciences Expression via Pathway-Focused PCR Arrays including HIP1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIP1 |
Orthologs
for HIP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for HIP1 gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
HIP11 |
huntingtin interacting protein 1 |
76.47(n)
80.24(a) |
|
770683 XM_001232952.1 XP_001232953.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
hip11 |
huntingtin interacting protein 1 |
66.86(n)
69.25(a) |
|
793823 NM_001166205.1 NP_001159677.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG109713 |
cytoskeleton organization and biogenesis
actin more |
30(a) |
|
69E2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
ZK370.3b3
hipr-11 |
Protein HIPR-11 |
31(a)
(best of 2)3
45.1(n)1
36.84(a)1 |
|
III(8791926-8796528)3
1762241 NM_171215.41 NP_741253.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
SLA21 |
Sla2p |
40.05(n)
24.89(a) |
|
855478 NP_014156.2 |
ENSEMBL Gene Tree for HIP1 (if available)
TreeFam Gene Tree for HIP1 (if available) |
Paralogs
for HIP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIP1 gene
- TLN22 HIP1R2 MESDC12 TLN12
1 SIMAP similar gene for HIP1 using alignment to 4 protein entries: HIP1_HUMAN (see all proteins):HIP1R
HIP1 for paralogs About GeneDecksing
|
Genomic Variants
for HIP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIP1 (75162621 - 75368280 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for HIP1
6 CNVs: 37760 3686 9574 52281 22956 64864
Human Gene Mutation Database (HGMD): HIP1
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for HIP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIP1 for disorders About GeneDecksing
OMIM gene information: 601767
OMIM disorders: 176807
UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291
Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML).Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion ofthe two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed
20/21  diseases for HIP1 (see all 21): About MalaCardshuntington's disease charcot-marie-tooth disease distal hereditary motor neuropathy myelomonocytic leukemia
chronic myelomonocytic leukemia tooth disease systemic lupus erythematosus intellectual disability
lupus erythematosus prostate cancer, progression of myeloproliferative disorder prostate cancer
neuropathy noma cataract prostatitis
hematopoiesis leukemia colon cancer neuronitis
1 disease from the University of Copenhagen DISEASES database for HIP1:Huntington's disease 5 Novoseek disease relationships for HIP1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| huntington disease |
77.5 |
8 |
15906374 (1), 9616134 (1), 18637945 (1), 20179344 (1) (see all 6) |
| leukemia myelomonocytic chronic |
75 |
3 |
9616134 (1), 10428802 (1), 11287412 (1) |
| prostate cancer |
5.95 |
7 |
15899803 (3), 18670643 (1), 16027218 (1) |
| tumors |
0 |
7 |
12781365 (3), 15899803 (2), 17440072 (1) |
| cancer |
0 |
5 |
17452370 (1), 14998932 (1), 15899803 (1), 15059611 (1) |
Human Genome Epidemiology (HuGE) Navigator: HIP1 (1 document)
Export disorders for HIP1 gene to outside databases
|
Publications
for HIP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIP1 gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with HIP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. (PubMed id 9147654)1, 2, 3, 9 Wanker E.E....Lehrach H. (1997)
- HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. (PubMed id 9140394)1, 2, 3, 9 Kalchman M.A.... Hayden M.R. (1997)
- Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain. (PubMed id 11007801)1, 2, 9 Hackam A.S.... Hayden M.R. (2000)
- HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3- phosphoinositides via epsin N-terminal homology domains. (PubMed id 14732715)1, 2, 9 Hyun T.S.... Ross T.S. (2004)
- HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2. (PubMed id 11517213)1, 2, 9 Metzler M.... Hayden M.R. (2001)
- Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. (PubMed id 11788820)1, 2, 9 Gervais F.G.... Nicholson D.W. (2002)
- Clathrin- and AP-2-binding sites in HIP1 uncover a general assembly role for endocytic accessory proteins. (PubMed id 11577110)1, 2, 9 Mishra S.K....Traub L.M. (2001)
- The huntingtin interacting protein HIP1 is a clathrin and alpha- adaptin-binding protein involved in receptor-mediated endocytosis. (PubMed id 11532990)1, 2, 9 Waelter S....Wanker E.E. (2001)
- Fusion of Huntingtin interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33;q11.2). (PubMed id 9616134)1, 2, 9 Ross T.S.... Gilliland D.G. (1998)
- Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. (PubMed id 15533940)1, 2, 9 Chen C.-Y. and Brodsky F.M. (2005)
|
External Searches for HIP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for HIP1 gene:
Search GeneIP for patents involving HIP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HIP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for HIP1 | | OriGene shRNA RFP for HIP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIP1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIP1 | | OriGene 3'-UTR Clone for HIP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIP1 | | OriGene Custom Protein Services for HIP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIP1 |
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| | | | Search Tocris compounds for HIP1 |
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 | | | HIP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIP1 |
|  |  |  | | | | ThermoFisher Antibodies for HIP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIP1 |
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