Aliases for HIP1 Gene
Aliases for HIP1 Gene
External Ids for HIP1 Gene
- HGNC: 4913
- Entrez Gene: 3092
- Ensembl: ENSG00000127946
- OMIM: 601767
- UniProtKB: O00291
Previous GeneCards Identifiers for HIP1 Gene
- GC07M073699
- GC07M074762
- GC07M074776
- GC07M074777
- GC07M074808
- GC07M075001
- GC07M075162
- GC07M070249
Summaries for HIP1 Gene
-
The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for HIP1 Gene
HIP1 (Huntingtin Interacting Protein 1) is a Protein Coding gene. Diseases associated with HIP1 include Prostate Cancer and Huntington Disease. Among its related pathways are Vesicle-mediated transport and Coregulation of Androgen receptor activity. Gene Ontology (GO) annotations related to this gene include binding and structural constituent of cytoskeleton. An important paralog of this gene is HIP1R.
UniProtKB/Swiss-Prot for HIP1 Gene
-
Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454).
Additional gene information for HIP1 Gene
- Monarch Initiative
- Search for HIP1 at DataMed
- Search for HIP1 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIP1 Gene
Genomics for HIP1 Gene
GeneHancer (GH) Regulatory Elements for HIP1 Gene
Promoters and enhancers for HIP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HIP1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the HIP1 gene promoter:
Regulatory Element Products
Genomic Locations for HIP1 Gene
Genomic Locations for HIP1 Gene
- chr7:75,533,298-75,738,972
- (GRCh38/hg38)
- Size:
- 205,675 bases
- Orientation:
- Minus strand
- chr7:75,162,621-75,368,280
- (GRCh37/hg19)
Genomic View for HIP1 Gene
Genes around HIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by Ensembl
- 7q11.23 by Entrez Gene
- 7q11.23 by HGNC
HIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIP1 Gene
Proteins for HIP1 Gene
-
Protein details for HIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00291-HIP1_HUMAN
- Recommended name:
- Huntingtin-interacting protein 1
- Protein Accession:
- O00291
- B4E3I7
- E7ES17
- O00328
- Q2TB58
- Q8TDL4
- V5LU97
Protein attributes for HIP1 Gene
- Size:
- 1037 amino acids
- Molecular mass:
- 116221 Da
- Quaternary structure:
-
- Homodimer. Binds actin. Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds to IFT57. In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57. Interacts with CLTB (via N-terminus). Interacts (via coiled coil domain) with AR. Interacts with AP2A1, AP2A2, CLTC and HIP1R. Interacts with GRIA1, GRIN2A AND GRIN2B.
- Miscellaneous:
-
- The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.
- SequenceCaution:
-
- Sequence=AAC51257.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for HIP1 Gene
Post-translational modifications for HIP1 Gene
- Ubiquitination at posLast=99 and posLast=1717
Other Protein References for HIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HIP1
-
Abcam antibodies for HIP1
- Invitrogen Antibodies for HIP1
- GeneTex HIP1 antibody for HIP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HIP1
Protein Products
-
OriGene Purified Proteins for HIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for HIP1
- Origene Custom Protein Services for HIP1
-
Cloud-Clone Corp. Proteins for HIP1
- Search GeneTex for Proteins for HIP1
-
Abcam proteins for HIP1
Assay Products
No data available for DME Specific Peptides for HIP1 Gene
Domains & Families for HIP1 Gene
Gene Families for HIP1 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for HIP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00291UniProtKB/Swiss-Prot:
HIP1_HUMAN :- The pseudo DED region (pDED) mediates the interaction with IFT57.
- Belongs to the SLA2 family.
- Domain:
-
- The pseudo DED region (pDED) mediates the interaction with IFT57.
- Binds F-actin via the talin-like I/LWEQ domain.
- Family:
-
- Belongs to the SLA2 family.
Function for HIP1 Gene
Molecular function for HIP1 Gene
- GENATLAS Biochemistry:
- huntingtin interacting protein,116kDa,expressed in neurons of the central nervous system,homolog to S.cerevisae SPa2p,putatively involved in neuronal cytoskeleton function
- UniProtKB/Swiss-Prot Function:
- Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454).
Phenotypes From GWAS Catalog for HIP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005154 | epidermal growth factor receptor binding | TAS | 20074057 |
| GO:0005200 | structural constituent of cytoskeleton | TAS | 9140394 |
| GO:0005515 | protein binding | IPI | 9140394 |
| GO:0005543 | phospholipid binding | IEA | -- |
| GO:0005546 | NOT phosphatidylinositol-4,5-bisphosphate binding | IDA | 14732715 |
Phenotypes for HIP1 Gene
- MGI mutant phenotypes for HIP1:
-
inferred from 6 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hematopoietic system phenotype
- skeleton phenotype
- liver/biliary system phenotype
- GenomeRNAi human phenotypes for HIP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIP1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for HIP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
- Search ViGene Biosciences for HIP1
CRISPR Products
-
OriGene CRISPR knockouts for HIP1
- genomics-online: gRNA clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
- Applied Biological Materials CRISPR for HIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIP1
- GenScript: Design CRISPR guide RNA sequences for HIP1
miRNA for HIP1 Gene
- miRTarBase miRNAs that target HIP1
-
- hsa-mir-4999-3p (MIRT222721)
- hsa-mir-1273e (MIRT446602)
- hsa-mir-6783-3p (MIRT446604)
- hsa-mir-1343-3p (MIRT446605)
- hsa-mir-636 (MIRT446606)
- hsa-mir-5196-5p (MIRT446607)
- hsa-mir-4747-5p (MIRT446608)
- hsa-mir-4646-5p (MIRT446609)
- hsa-mir-204-3p (MIRT446610)
- hsa-mir-6852-5p (MIRT446611)
- hsa-mir-6742-3p (MIRT446612)
- hsa-mir-939-3p (MIRT446613)
- hsa-mir-520f-3p (MIRT446614)
- hsa-mir-302c-3p (MIRT446615)
- hsa-mir-520e (MIRT446616)
- hsa-mir-520d-3p (MIRT446617)
- hsa-mir-520c-3p (MIRT446618)
- hsa-mir-520b (MIRT446619)
- hsa-mir-520a-3p (MIRT446620)
- hsa-mir-373-3p (MIRT446621)
- hsa-mir-372-3p (MIRT446622)
- hsa-mir-302e (MIRT446623)
- hsa-mir-302d-3p (MIRT446624)
- hsa-mir-302b-3p (MIRT446625)
- hsa-mir-302a-3p (MIRT446626)
- hsa-mir-5089-5p (MIRT509471)
- hsa-mir-6506-5p (MIRT509472)
- hsa-mir-619-5p (MIRT509473)
- hsa-mir-6809-3p (MIRT628147)
- hsa-mir-6833-3p (MIRT628148)
- hsa-mir-4768-5p (MIRT628149)
- hsa-mir-4753-3p (MIRT628150)
- hsa-mir-6873-3p (MIRT628151)
- hsa-mir-130b-5p (MIRT628152)
- hsa-mir-6817-3p (MIRT628153)
- hsa-mir-7110-3p (MIRT628154)
- hsa-mir-138-2-3p (MIRT628155)
- hsa-mir-4674 (MIRT628156)
- hsa-mir-4437 (MIRT628157)
- hsa-mir-760 (MIRT628158)
- hsa-mir-642b-3p (MIRT628159)
- hsa-mir-642a-3p (MIRT628160)
- hsa-mir-6719-3p (MIRT628161)
- hsa-mir-4526 (MIRT628162)
- hsa-mir-3660 (MIRT628163)
- hsa-mir-6730-3p (MIRT628164)
- hsa-mir-301b-5p (MIRT628165)
- hsa-mir-301a-5p (MIRT628166)
- hsa-mir-6836-3p (MIRT634631)
- hsa-mir-6829-3p (MIRT634632)
- hsa-mir-6791-3p (MIRT634633)
- hsa-mir-6778-3p (MIRT634634)
- hsa-mir-210-5p (MIRT634635)
- hsa-mir-150-5p (MIRT634636)
- hsa-mir-6747-3p (MIRT634637)
- hsa-mir-6752-3p (MIRT634638)
- hsa-mir-7108-3p (MIRT634639)
- hsa-mir-6801-3p (MIRT634640)
- hsa-mir-6810-3p (MIRT634641)
- hsa-mir-186-3p (MIRT634642)
- hsa-mir-520h (MIRT634643)
- hsa-mir-520g-3p (MIRT634644)
- hsa-mir-512-3p (MIRT634645)
- hsa-mir-93-5p (MIRT634646)
- hsa-mir-526b-3p (MIRT634647)
- hsa-mir-519d-3p (MIRT634648)
- hsa-mir-20b-5p (MIRT634649)
- hsa-mir-20a-5p (MIRT634650)
- hsa-mir-17-5p (MIRT634651)
- hsa-mir-106b-5p (MIRT634652)
- hsa-mir-106a-5p (MIRT634653)
- hsa-mir-640 (MIRT702952)
- hsa-mir-5589-5p (MIRT702953)
- hsa-mir-4731-5p (MIRT702954)
miRNA Products
- Search ViGene Biosciences for HIP1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for HIP1
- Browse OriGene Inhibitory RNA Products For HIP1
- genomics-online: shRNA clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
Clone Products
- Sino Biological Human cDNA Clone for HIP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HIP1
- Applied Biological Materials Clones for HIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for HIP1
-
ViGene Biosciences adenoviral particle packaged cDNA for HIP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIP1 Gene
Localization for HIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIP1 Gene
- Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| golgi apparatus | 5 |
| cytoskeleton | 4 |
| plasma membrane | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Vesicles (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 20074057 |
| GO:0005737 | cytoplasm | IDA | 11604514 |
| GO:0005794 | Golgi apparatus | IDA | 11788820 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | TAS | 9147654 |
Pathways & Interactions for HIP1 Gene
Pathways by source for HIP1 Gene
1 BioSystems pathway for HIP1 Gene
3 Reactome pathways for HIP1 Gene
1 KEGG pathway for HIP1 Gene
2 GeneGo (Thomson Reuters) pathways for HIP1 Gene
1 Qiagen pathway for HIP1 Gene
Interacting Proteins for HIP1 Gene
Selected Interacting proteins:
ENSP00000336747
O00291-HIP1_HUMAN
for HIP1 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006897 | endocytosis | IEA | -- |
| GO:0006915 | apoptotic process | IDA | 11788820 |
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | 11788820 |
Transcripts for HIP1 Gene
mRNA/cDNA for HIP1 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (176) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIP1
- genomics-online: gRNA clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
- Applied Biological Materials CRISPR for HIP1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIP1
- GenScript: Design CRISPR guide RNA sequences for HIP1
miRNA Products
- Search ViGene Biosciences for HIP1
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for HIP1
- Browse OriGene Inhibitory RNA Products For HIP1
- genomics-online: shRNA clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
Clone Products
- Sino Biological Human cDNA Clone for HIP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for HIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HIP1
- Applied Biological Materials Clones for HIP1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for HIP1 Gene
This gene is overexpressed in Breast (9.0) and Bone marrow stromal cell (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HIP1 Gene:
HIP1SOURCE GeneReport for Unigene cluster for HIP1 Gene:
Hs.329266mRNA Expression by UniProt/SwissProt for HIP1 Gene:
O00291-HIP1_HUMAN
Tissue specificity:
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
Evidence on tissue expression from TISSUES for HIP1 Gene
- Nervous system(4.6)
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs for HIP1
-
OriGene qPCR primer pairs and template standards for HIP1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIP1 Gene
Orthologs for HIP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIP1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HIP1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HIP1 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hip1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Hip1 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HIP1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIP1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HIP1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HIP1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hip1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hip1 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10971 35 |
|
|
|
| Hip1 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | hipr-1 33 |
|
||
| tag-138 34 |
|
ManyToMany | |||
| ZK370.3a 35 |
|
|
|||
| ZK370.3b 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SLA2 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11202 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | end4 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.11706 33 |
|
- Species where no ortholog for HIP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIP1 Gene
(1) SIMAP similar genes for HIP1 Gene using alignment to 5 proteins:
Variants for HIP1 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs117129747 | benign, not specified | 75,553,503(-) | C/T | coding_sequence_variant, missense_variant | |
| rs1000058757 | -- | 75,629,396(-) | A/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000075992 | -- | 75,703,169(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000109565 | -- | 75,546,182(-) | G/A | intron_variant | |
| rs1000130814 | -- | 75,637,491(-) | T/C | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
8.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.79;
66.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HIP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIP1 Gene
Disorders for HIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| prostate cancer |
|
|
| huntington disease |
|
|
| chronic myelomonocytic leukemia |
|
|
| spinal disease |
|
|
Search HIP1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HIP1_HUMAN- Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134). {ECO:0000269 PubMed:9616134}.
Additional Disease Information for HIP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for HIP1 Gene
Publications for HIP1 Gene
- HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. (PMID: 9140394) Kalchman MA … Hayden MR (Nature genetics 1997) 2 3 4 22 58
- HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. (PMID: 9147654) Wanker EE … Lehrach H (Human molecular genetics 1997) 2 3 4 22 58
- Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease. (PMID: 16847693) Metzger S … Riess O (Human genetics 2006) 3 22 44 58
- Huntingtin-interacting protein 1 (Hip1) and Hip1-related protein (Hip1R) bind the conserved sequence of clathrin light chains and thereby influence clathrin assembly in vitro and actin distribution in vivo. (PMID: 15533940) Chen CY … Brodsky FM (The Journal of biological chemistry 2005) 3 4 22 58
- Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. (PMID: 16027218) Mills IG … Neal DE (The Journal of cell biology 2005) 3 4 22 58
Products for HIP1 Gene
- Browse R&D Systems for Antibodies
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- OriGene Purified Proteins for HIP1
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for HIP1
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- OriGene qPCR primer pairs and template standards for HIP1
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HIP1
- GenScript: Next-day shipping of latest version cDNA ORF clones for HIP1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HIP1
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- GenScript: Design CRISPR guide RNA sequences for HIP1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for HIP1
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- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for HIP1
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- Novus Biologicals Tissue Microarrays
- Abcam antibodies for HIP1
- Abcam proteins for HIP1
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- Browse Antibodies at Cloud-Clone Corp.
- Cloud-Clone Corp. Proteins for HIP1
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for HIP1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIP1
- VectorBuilder custom plasmid, inducible vectors for HIP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for HIP1
- antibodies-online: Search results for 61 available HIP1 Antibodies ranked by validation data
- Compare Top HIP1 Antibodies
- antibodies-online: Search results for 2 available HIP1 Elisa Kits ranked by validation data
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- Recommended
- antibodies-online: Search results for 4 available HIP1 Proteins ranked by validation data
- Compare Top HIP1 Proteins
- GeneTex HIP1 antibody for HIP1
- Search GeneTex for Proteins for HIP1
- ViGene Biosciences adenoviral particle packaged cDNA for HIP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
- Search ViGene Biosciences for HIP1
- Santa Cruz Biotechnology (SCBT) Antibodies for HIP1
- Search Santa Cruz Biotechnology (SCBT) for HIP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIP1
- Horizon Cell Lines for HIP1
- genomics-online: cdna clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
- orf clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
- genomics-online: gRNA clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
- genomics-online: primer clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
- genomics-online: shRNA clones - Search results for 84 available HIP1 gene related products
- Overview of 84 available HIP1 gene related products
Sources for HIP1 Gene
- (1) GeneCards
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- (8) Gene Wiki
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- (28) ASD
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- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
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- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
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- (47) Atlas
- (48) Cell Signaling Technology
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- (50) H-invDB
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- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
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- (68) Cloud-Clone Corp.
- (69) OCA
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
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- (86) RefSeq
- (87) BioSystems
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- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
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- (94) PaxDb
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- (96) Addgene
- (97) antibodies-online
- (98) CYP
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