Aliases for HIP1 Gene
Aliases for HIP1 Gene
External Ids for HIP1 Gene
- HGNC: 4913
- Entrez Gene: 3092
- Ensembl: ENSG00000127946
- OMIM: 601767
- UniProtKB: O00291
Previous GeneCards Identifiers for HIP1 Gene
- GC07M073699
- GC07M074762
- GC07M074776
- GC07M074777
- GC07M074808
- GC07M075001
- GC07M075162
- GC07M070249
Summaries for HIP1 Gene
-
The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
GeneCards Summary for HIP1 Gene
HIP1 (Huntingtin Interacting Protein 1) is a Protein Coding gene. Diseases associated with HIP1 include Huntington Disease and Chronic Myelomonocytic Leukemia. Among its related pathways are Normal wtCFTR traffic / ER-to-Golgi and Coregulation of Androgen receptor activity. GO annotations related to this gene include binding and structural constituent of cytoskeleton. An important paralog of this gene is TLN1.
UniProtKB/Swiss-Prot for HIP1 Gene
-
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIP1 Gene
Genomics for HIP1 Gene
Regulatory Elements for HIP1 Gene
Enhancers for HIP1 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around HIP1 on UCSC Golden Path with GeneCards custom track
Promoters for HIP1 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around HIP1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIP1 gene promoter:
Regulatory Element Products
Genomic Location for HIP1 Gene
- Chromosome:
- 7
- Start:
- 75,533,298 bp from pter
- End:
- 75,738,972 bp from pter
- Size:
- 205,675 bases
- Orientation:
- Minus strand
Genomic View for HIP1 Gene
Genes around HIP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by Ensembl
- 7q11.23 by Entrez Gene
- 7q11.23 by HGNC
HIP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIP1 Gene
Proteins for HIP1 Gene
-
Protein details for HIP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00291-HIP1_HUMAN
- Recommended name:
- Huntingtin-interacting protein 1
- Protein Accession:
- O00291
- B4E3I7
- E7ES17
- O00328
- Q2TB58
- Q8TDL4
- V5LU97
Protein attributes for HIP1 Gene
- Size:
- 1037 amino acids
- Molecular mass:
- 116221 Da
- Quaternary structure:
-
- Homodimer. Binds actin. Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds to IFT57. In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT. However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is inhibited, promoting the interaction between HIP1 and IFT57. Interacts with CLTB (via N-terminus). Interacts (via coiled coil domain) with AR. Interacts with AP2A1, AP2A2, CLTC and HIP1R. Interacts with GRIA1, GRIN2A AND GRIN2B.
- Miscellaneous:
-
- The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.
- SequenceCaution:
-
- Sequence=AAC51257.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for HIP1 Gene
Post-translational modifications for HIP1 Gene
Other Protein References for HIP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HIP1
- Novus Biologicals Antibodies for HIP1
- Invitrogen Antibodies for HIP1
- antibodies-online Antibodies for HIP1: See all 50
- GeneTex HIP1 antibody for HIP1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HIP1
Protein Products
-
OriGene Purified Proteins for HIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for HIP1
- Origene Custom Protein Services for HIP1
- antibodies-online Proteins for HIP1: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HIP1
Assay Products
- antibodies-online Kits for HIP1: See all 2
No data available for DME Specific Peptides for HIP1 Gene
Domains & Families for HIP1 Gene
Protein Domains for HIP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00291UniProtKB/Swiss-Prot:
HIP1_HUMAN :- The pseudo DED region (pDED) mediates the interaction with IFT57.
- Belongs to the SLA2 family.
- Domain:
-
- The pseudo DED region (pDED) mediates the interaction with IFT57.
- Binds F-actin via the talin-like I/LWEQ domain.
- Contains 1 ENTH (epsin N-terminal homology) domain.
- Contains 1 I/LWEQ domain.
- Family:
-
- Belongs to the SLA2 family.
No data available for Gene Families for HIP1 Gene
Function for HIP1 Gene
Molecular function for HIP1 Gene
- GENATLAS Biochemistry:
- huntingtin interacting protein,116kDa,expressed in neurons of the central nervous system,homolog to S.cerevisae SPa2p,putatively involved in neuronal cytoskeleton function
- UniProtKB/Swiss-Prot Function:
- Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005543 | phospholipid binding | IEA | -- |
Phenotypes for HIP1 Gene
- MGI mutant phenotypes for HIP1:
-
inferred from 6 alleles
- cellular phenotype
- mortality/aging
- behavior/neurological phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- liver/biliary system phenotype
- normal phenotype
- immune system phenotype
- growth/size/body region phenotype
- hematopoietic system phenotype
- tumorigenesis
- homeostasis/metabolism phenotype
- respiratory system phenotype
- nervous system phenotype
- vision/eye phenotype
- muscle phenotype
- skeleton phenotype
- GenomeRNAi human phenotypes for HIP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
- Search ViGene Biosciences for HIP1
CRISPR Products
-
OriGene CRISPR knockouts for HIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIP1
- GenScript: Design CRISPR guide RNA sequences for HIP1
miRNA for HIP1 Gene
- miRTarBase miRNAs that target HIP1
-
- hsa-mir-4999-3p (MIRT222721)
- hsa-mir-1273e (MIRT446602)
- hsa-mir-6783-3p (MIRT446604)
- hsa-mir-1343-3p (MIRT446605)
- hsa-mir-636 (MIRT446606)
- hsa-mir-5196-5p (MIRT446607)
- hsa-mir-4747-5p (MIRT446608)
- hsa-mir-4646-5p (MIRT446609)
- hsa-mir-204-3p (MIRT446610)
- hsa-mir-6852-5p (MIRT446611)
- hsa-mir-6742-3p (MIRT446612)
- hsa-mir-939-3p (MIRT446613)
- hsa-mir-520f-3p (MIRT446614)
- hsa-mir-302c-3p (MIRT446615)
- hsa-mir-520e (MIRT446616)
- hsa-mir-520d-3p (MIRT446617)
- hsa-mir-520c-3p (MIRT446618)
- hsa-mir-520b (MIRT446619)
- hsa-mir-520a-3p (MIRT446620)
- hsa-mir-373-3p (MIRT446621)
- hsa-mir-372-3p (MIRT446622)
- hsa-mir-302e (MIRT446623)
- hsa-mir-302d-3p (MIRT446624)
- hsa-mir-302b-3p (MIRT446625)
- hsa-mir-302a-3p (MIRT446626)
- hsa-mir-5089-5p (MIRT509471)
- hsa-mir-6506-5p (MIRT509472)
- hsa-mir-619-5p (MIRT509473)
- hsa-mir-6809-3p (MIRT628147)
- hsa-mir-6833-3p (MIRT628148)
- hsa-mir-4768-5p (MIRT628149)
- hsa-mir-4753-3p (MIRT628150)
- hsa-mir-6873-3p (MIRT628151)
- hsa-mir-130b-5p (MIRT628152)
- hsa-mir-6817-3p (MIRT628153)
- hsa-mir-7110-3p (MIRT628154)
- hsa-mir-138-2-3p (MIRT628155)
- hsa-mir-4674 (MIRT628156)
- hsa-mir-4437 (MIRT628157)
- hsa-mir-760 (MIRT628158)
- hsa-mir-642b-3p (MIRT628159)
- hsa-mir-642a-3p (MIRT628160)
- hsa-mir-6719-3p (MIRT628161)
- hsa-mir-4526 (MIRT628162)
- hsa-mir-3660 (MIRT628163)
- hsa-mir-6730-3p (MIRT628164)
- hsa-mir-301b-5p (MIRT628165)
- hsa-mir-301a-5p (MIRT628166)
- hsa-mir-6836-3p (MIRT634631)
- hsa-mir-6829-3p (MIRT634632)
- hsa-mir-6791-3p (MIRT634633)
- hsa-mir-6778-3p (MIRT634634)
- hsa-mir-210-5p (MIRT634635)
- hsa-mir-150-5p (MIRT634636)
- hsa-mir-6747-3p (MIRT634637)
- hsa-mir-6752-3p (MIRT634638)
- hsa-mir-7108-3p (MIRT634639)
- hsa-mir-6801-3p (MIRT634640)
- hsa-mir-6810-3p (MIRT634641)
- hsa-mir-186-3p (MIRT634642)
- hsa-mir-520h (MIRT634643)
- hsa-mir-520g-3p (MIRT634644)
- hsa-mir-512-3p (MIRT634645)
- hsa-mir-93-5p (MIRT634646)
- hsa-mir-526b-3p (MIRT634647)
- hsa-mir-519d-3p (MIRT634648)
- hsa-mir-20b-5p (MIRT634649)
- hsa-mir-20a-5p (MIRT634650)
- hsa-mir-17-5p (MIRT634651)
- hsa-mir-106b-5p (MIRT634652)
- hsa-mir-106a-5p (MIRT634653)
- hsa-mir-640 (MIRT702952)
- hsa-mir-5589-5p (MIRT702953)
- hsa-mir-4731-5p (MIRT702954)
miRNA Products
- Search ViGene Biosciences for HIP1
Clone Products
- OriGene clones in human for HIP1
- OriGene ORF clones in human,mouse,rat for HIP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIP1
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HIP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIP1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HIP1 Gene
Localization for HIP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIP1 Gene
- Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 2 |
| endoplasmic reticulum | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| plasma membrane | 1 |
No data available for Gene Ontology (GO) - Cellular Components for HIP1 Gene
Pathways & Interactions for HIP1 Gene
More details on SuperPathways for HIP1Pathways by source for HIP1 Gene
2 BioSystems pathways for HIP1 Gene
1 KEGG pathway for HIP1 Gene
2 GeneGo (Thomson Reuters) pathways for HIP1 Gene
1 Qiagen pathway for HIP1 Gene
Interacting Proteins for HIP1 Gene
Selected Interacting proteins:
O00291-HIP1_HUMAN
ENSP00000336747
for HIP1 Gene via
MINT
STRING
UniProtKB
I2D
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | IDA | 11788820 |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0072583 | clathrin-mediated endocytosis | IEA | -- |
Transcripts for HIP1 Gene
mRNA/cDNA for HIP1 Gene
- (5) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (6) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIP1
- GenScript: Design CRISPR guide RNA sequences for HIP1
miRNA Products
- Search ViGene Biosciences for HIP1
Clone Products
- OriGene clones in human for HIP1
- OriGene ORF clones in human,mouse,rat for HIP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HIP1
Flow Cytometry Products
Expression for HIP1 Gene
This gene is overexpressed in Breast (9.0) and Bone marrow stromal cell (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIP1 Gene
SOURCE GeneReport for Unigene cluster for HIP1 Gene Hs.329266
mRNA Expression by UniProt/SwissProt for HIP1 Gene
O00291-HIP1_HUMAN
Tissue specificity:
Ubiquitously expressed with the highest level in brain. Expression is up-regulated in prostate and colon cancer.
Primer Products
-
OriGene qPCR primer pairs for HIP1
-
OriGene qPCR primer pairs and template standards for HIP1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HIP1 Gene
Orthologs for HIP1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | HIP1 35 |
|
||
| HIP1 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | HIP1 35 |
|
||
| HIP1 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Hip1 35 |
|
||
| Hip1 16 |
|
||||
| Hip1 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | HIP1 35 |
|
||
| HIP1 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Hip1 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HIP1 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIP1 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HIP1 35 |
|
||
| HIP1 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | HIP1 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hip1 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hip1 35 |
|
||
| hip1 36 |
|
OneToOne | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG10971 37 |
|
|
|
| Hip1 36 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | ZK370.3a 37 |
|
|
|
| ZK370.3b 37 |
|
|
|||
| hipr-1 35 |
|
||||
| tag-138 36 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SLA2 36 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.11706 35 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU11202 35 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | end4 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
ManyToMany | |
| -- 36 |
|
ManyToMany |
- Species with no ortholog for HIP1:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HIP1 Gene
(1) SIMAP similar genes for HIP1 Gene using alignment to 5 proteins:
Variants for HIP1 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17149023 | - | 75,568,214(+) | GCTCC(A/T)TGAAG | reference, missense | |
| rs794348 | -- | 75,577,856(-) | cgccc(A/G)gctaa | intron-variant | |
| rs794349 | -- | 75,575,817(-) | ACAGA(A/G)GGACC | intron-variant | |
| rs794350 | -- | 75,574,581(-) | atggt(A/G)tctta | intron-variant | |
| rs794351 | -- | 75,574,261(-) | tgctg(A/G)agtgc | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv888381 | CNV | Gain | 21882294 |
| nsv528969 | CNV | Gain | 19592680 |
| dgv2102e1 | CNV | Complex | 17122850 |
| essv14753 | CNV | CNV | 17122850 |
| dgv120n16 | CNV | Deletion | 17901297 |
| nsv831036 | CNV | Loss | 17160897 |
| nsv518028 | CNV | Gain | 19592680 |
| nsv523858 | CNV | Loss | 19592680 |
| esv2674202 | CNV | Deletion | 23128226 |
| nsv509209 | CNV | Insertion | 20534489 |
| nsv888383 | CNV | Loss | 21882294 |
| esv2734673 | CNV | Deletion | 23290073 |
| esv2734674 | CNV | Deletion | 23290073 |
| nsv509210 | CNV | Insertion | 20534489 |
| esv2734675 | CNV | Deletion | 23290073 |
| esv2734676 | CNV | Deletion | 23290073 |
| esv1647869 | CNV | Deletion | 17803354 |
| nsv366198 | CNV | Loss | 16902084 |
| nsv888384 | CNV | Loss | 21882294 |
| nsv464564 | CNV | Gain | 19166990 |
| nsv888385 | CNV | Loss | 21882294 |
| nsv528166 | CNV | Gain | 19592680 |
| nsv527399 | CNV | Gain | 19592680 |
| esv22251 | CNV | Gain | 19812545 |
| esv2421823 | CNV | Duplication | 20811451 |
| nsv441991 | CNV | CNV | 18776908 |
| esv2667226 | CNV | Deletion | 23128226 |
| nsv515696 | CNV | Gain | 19592680 |
| nsv818517 | CNV | Gain | 17921354 |
Residual Variation Intolerance Score:
8.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.79;
66.83% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIP1 Gene
- Human Gene Mutation Database (HGMD)
- HIP1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIP1 Gene
Disorders for HIP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| huntington disease |
|
|
| chronic myelomonocytic leukemia |
|
|
| prostate cancer |
|
Search HIP1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HIP1_HUMAN- Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134). {ECO:0000269 PubMed:9616134}.
Relevant External Links for HIP1
No data available for Genatlas for HIP1 Gene
Publications for HIP1 Gene
- HIP-I: a huntingtin interacting protein isolated by the yeast two- hybrid system. (PMID: 9147654) Wanker E.E. … Lehrach H. (Hum. Mol. Genet. 1997) 2 3 4 23 67
- HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain. (PMID: 9140394) Kalchman M.A. … Hayden M.R. (Nat. Genet. 1997) 2 3 23
- Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain. (PMID: 20179344) Wilbur J.D. … Fletterick R.J. (Acta Crystallogr. D Biol. Crystallogr. 2010) 3 23
- HIP1 exhibits an early recruitment and a late stage function in the maturation of coated pits. (PMID: 19626275) Gottfried I. … Ashery U. (Cell. Mol. Life Sci. 2009) 3 23
- Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor. (PMID: 17440072) Bradley S.V. … Ross T.S. (Cancer Res. 2007) 3 23
Products for HIP1 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
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- Browse Proteins and Enzymes
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- Browse Cell Selection and Detection Kits
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- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HIP1
- Search Origene for MassSpec and Protein Over-expression Lysates for HIP1
- Origene Custom Protein Services for HIP1
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for HIP1
- Browse OriGene Inhibitory RNA Products For HIP1
- OriGene qPCR primer pairs for HIP1
- OriGene qPCR primer pairs and template standards for HIP1
- OriGene CRISPR knockouts for HIP1
- OriGene clones in human for HIP1
- OriGene ORF clones in human,mouse,rat for HIP1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for HIP1
- GenScript Custom Assay Services for HIP1
- GenScript Custom overexpressing Cell Line Services for HIP1
- GenScript: Design CRISPR guide RNA sequences for HIP1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HIP1
- Novus Biologicals Antibodies for HIP1
- Novus Biologicals proteins and lysates for HIP1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for HIP1
- antibodies-online Antibodies for HIP1: See all 50
- antibodies-online Kits for HIP1: See all 2
- antibodies-online Proteins for HIP1: See all 4
- Search antibodies-online for peptides
- GeneTex HIP1 antibody for HIP1
- Search GeneTex for Proteins for HIP1
- ViGene Biosciences adenoviral particle packaged cDNA for HIP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIP1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIP1 gene
- Search ViGene Biosciences for HIP1
- Search ViGene Biosciences for HIP1
- Santa Cruz Biotechnology (SCBT) Antibodies for HIP1
- Search Santa Cruz Biotechnology (SCBT) for HIP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for HIP1
Sources for HIP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon