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HIP1 Gene

protein-coding   GIFtS: 60

GC07M075001
huntingtin interacting protein 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for HIP1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
HIP-I 3
ILWEQ 1, 2
MGC126506 2
Descriptions
huntingtin interacting protein 1 2
External Ids
HGNC: 49131
Entrez Gene: 30922
UniProtKB: O002913
Ensembl: ENSG000001279467
Search outside databases for aliases for HIP1 gene

Previous GC identifers: GC07M073699 GC07M074762 GC07M074776 GC07M074777 GC07M074808

Summaries
for HIP1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for HIP1:
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This
protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought
to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction
in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain.
This gene could help in the understanding of the normal function of huntingtin and also the
pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of
hematopoietic malignancies. An alternative splice variant of this gene has been described but its
full length sequence has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291
Function: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating
AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances
androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell
death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH
domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine
kinases following ligand-induced endocytosis. May play a functional role in the cell filament
networks. May be required for differentiation, proliferation, and/or survival of somatic and
germline progenitors

Genomic Location
for HIP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HIP1 gene  

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

HIP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M075001:     (about GC identifiers)

Start:
 75,001,345 bp from pter
End:
 75,206,215 bp from pter
Size:
 204,871 bases
Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 74,496,473-74,701,343     
RefSeq DNA sequence:
NC_000007.12  NT_007933.14  NT_079595.2  

Proteins
for HIP1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291 (See protein sequence)
Recommended Name: Huntingtin-interacting protein 1  
Size: 1037 amino acids; 116221 Da
Subunit: Binds HTT (via N-terminus). This interaction is restricted to the brain. Binds to IFT57.
In normal conditions, it poorly interacts with IFT57, HIP1 being strongly associated with HTT.
However, in mutant HTT proteins with a long poly-Gln region, interaction between HTT and HIP1 is
inhibited, promoting the interaction between HIP1 and IFT57. Interacts with CLTB (via N-terminus).
Interacts (via coiled coil domain) with AR. Interacts with AP2A1, AP2A2, CLTC and HIP1R. Interacts
with GRIA1, GRIN2A AND GRIN2B
Subcellular location: Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated
vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be
induced by AR
Miscellaneous: The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to
the length of the polyglutamine tract added to the huntingtin protein in Huntington disease
PDB structure from and Proteopedia :
2NO2 (3D)    2QA7 (3D)    
Secondary accessions: O00328 Q2TB58 Q8TDL4
Alternative splicing: 2 isoforms:  O00291-1   O00291-2   

REFSEQ proteins: NP_005329.3  

ENSEMBL proteins: 
ENSP00000336747 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Huntingtin Interacting Protein HIP1)
Human Recombinant Proteins from Abnova (HIP1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0005624 membrane fraction TAS9147654
GO:0005634 nucleus IEA--
GO:0005737 cytoplasm IDA11604514
GO:0005794 Golgi apparatus IDA11788820
GO:0005856 cytoskeleton TAS9147654
About this table

Antibodies for HIP1: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of HIP1
Sigma-Aldrich Antibodies for HIP1
Browse R&D Systems for Antibodies
Antibodies from Abcam (Huntingtin Interacting Protein HIP1), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (HIP1)
Novus Biologicals Antibodies for HIP1

Assays for HIP1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for HIP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR002558 ILWEQ
 IPR008942 ENTH_VHS
 IPR013809 Epsin-like_N
 IPR011417 ANTH


   GeneDecks  HIP1 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry O00291

ProtoNet protein and cluster: O00291

3 Blocks protein families:
IPB001026 Epsin N-terminal homology
IPB002558 I/LWEQ domain
IPB013809 Epsin-like


UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291
Domain: The pseudo DED region (pDED) mediates the interaction with IFT57
Similarity: Belongs to the SLA2 family
Similarity: Contains 1 ENTH (epsin N-terminal homology) domain
Similarity: Contains 1 I/LWEQ domain

Gene Function
for HIP1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (HIP1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (HIP1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005338

              Applied Biosystems Silencer® siRNAs for HIP1

              Sigma-Aldrich siRNA for HIP1  
                     Sigma-Aldrich shRNA Panels and shRNA for HIP1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005338
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005338
                                 untagged cDNA clones in CMV expression vector (see all 3): AF365404 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_005338

UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291
Function: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating
AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances
androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell
death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH
domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine
kinases following ligand-induced endocytosis. May play a functional role in the cell filament
networks. May be required for differentiation, proliferation, and/or survival of somatic and
germline progenitors

Genatlas biochemistry entry for HIP1:
huntingtin interacting protein,116kDa,expressed in neurons of the central nervous system,homolog to
S.cerevisae SPa2p,putatively involved in neuronal cytoskeleton function

10 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hip1):

behavior/neurologicalendocrine/exocrine glandgrowth/sizehematopoietic systemlethality-prenatal/perinatal
nervous systemnormalreproductive systemskeletonvision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003779 actin binding IEA--
GO:0005200 structural constituent of cytoskeleton TAS9140394
GO:0030276 clathrin binding IDA11577110
GO:0035091 phosphoinositide binding IDA14732715
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Pathways & Interactions
for HIP1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Millipore Pathway for HIP1
 Clathrin-dependent protein traffic

   GeneDecks  HIP1 for the pathways selected above  
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for  HIP1  (Your Favorite Gene powered by Ingenuity) 
 Clathrin-mediated Endocytosis
 Huntington's Disease Signaling

   GeneDecks  HIP1 for the pathways selected above  
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1 Kegg Pathway  (Kegg details for HIP1):
 hsa05016 Huntington's disease

   GeneDecks  HIP1 for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  HIP1 


5/34 Interacting proteins for HIP1 (ENSP000003367473 O002912) via UniProtKB, MINT, and/or STRING (see all 34 )
InteractantInteraction Details
GeneCardExternal ID(s)
AP2A1O957822STRING (score=.983) MINT-18401 MINT-18402 MINT-18399 MINT-18400
CLTCL1P536752STRING (score=.988) MINT-17143 MINT-17146 MINT-17144 MINT-17145
CLTCQ006102STRING (score=.998) MINT-3979944
HTTP428582MINT-3981386 MINT-3977977
PFDN1O609252MINT-63188
About this table

5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0006897 endocytosis IEA--
GO:0006917 induction of apoptosis IDA11007801
GO:0006919 activation of caspase activity IDA11788820
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Drugs & Compounds
for HIP1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HIP1
3 Novoseek chemical compound relationships for HIP1 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine 26.97 7 9616134 (2), 14732715 (2), 10910073 (1), 11588050 (1)
phenylalanine 20.33 1 11007801 (1)
lipid 0.00 3 14732715 (1), 17440072 (1)
About this table


Transcripts
for HIP1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (HIP1)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (HIP1)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005338

              Sigma-Aldrich siRNA for HIP1  
                     Sigma-Aldrich shRNA Panels and shRNA for HIP1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_005338  

REFSEQ mRNAs for HIP1 gene: 

NM_005338.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_005338  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005338
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005338
                                 untagged cDNA clones in CMV expression vector (see all 3): AF365404 

Additional cDNA sequence: 

AF365404.1 AF486833.1 AK296390.1 AK302382.1 AK304738.1 BC082970.1 BC110545.2 BC139786.1 
U79734.1 Y09420.1 

11 DOTS entries:

DT.409985  DT.95162272  DT.100658614  DT.70102239  DT.75195481  DT.97858552  DT.91735869  DT.99936096 
DT.121061226  DT.40118954  DT.75163476 

6 AceView cDNA sequences:

CA427404 AI272229 CA442592 BM990826 N33381 BQ690764 

highest scoring ESTs for HIP1:

AF365404 AF486833 AI240850 AI918081 AA071521 AA076887 AA077535 AA077616 AA078419 AA082343 

Unigene Cluster for HIP1:

Huntingtin interacting protein 1
Hs.329266  [show with all ESTs]
Unigene Representative Sequence: NM_005338


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000336926  

Expression
for HIP1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HIP1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for HIP1

1 / 2 / 3

9 probe-sets matching HIP1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

41061_at2, 3 U95-A 1 1.00 1.00 0.92 0.70 AF052288 0.20 1.00 0.72 1
73956_at2, 3 U95-D 2 0.44 0.50 0.63 0.98 AI240850 0.80 1.00 0.91 1
51980_at*2, 3 U95-B 1 1.00 1.00 0.77 1.34 AI918081 0.80 1.00 0.91 1

205425_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005338 0.60 1.00 0.82 1

205426_s_at2, 3 U133-A 1 1.00 1.00 -- -- U79734 0.40 1.00 0.76 1

226364_at*2, 3 U133-B 1 1.00 1.00 -- -- AU145049 0.40 1.00 0.76 1

205425_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

205426_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226364_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  HIP1 for binary patterns associated with the probe-sets selected above  
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About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.329266

Expression variation in blood from EXPOLDB for HIP1

UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291
Tissue specificity: Ubiquitously expressed with the highest level in brain. Expression is
up-regulated in prostate and colon cancer

Orthologs
for HIP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for HIP1 gene from 5/16 species (see all 16 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 HIP11   -- huntingtin interacting protein 1 88.22(n)
90.54(a)		 489814  XM_546932.2  XP_546932.2 
chimpanzee
(Pan troglodytes)		 HIP11   -- huntingtin interacting protein 1 99.74(n)
99.42(a)		 750861  XM_001175228.1  XP_001175228.1 
cow
(Bos taurus)		 HIP11   -- huntingtin interacting protein 1 87.4(n)
87.95(a)		 505919  XM_582283.3  XP_582283.3 
rat
(Rattus norvegicus)		 Hip11   -- huntingtin interacting protein 1 85.37(n)
88.24(a)		 192154  XM_347168.3  XP_347169.3 
mouse
(Mus musculus)		 Hip11, 5 5 (75.00 cM)5
 huntingtin interacting protein 11, 5 84.47(n)1
87.64(a)1		 2151141  NM_146001.11  NP_666113.11 
 AA6387905  AA6723045  (see all 23)
About this table        Species with no ortholog for HIP1

ENSEMBL Gene Tree for HIP1

Paralogs
for HIP1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for HIP1 gene
HIP1R2  

SNPs/Variants
for HIP1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/1386 NCBI SNPs in HIP1 are shown (see all 1386 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 168)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs11678301,2
A,C,F,H,O75004337(+) GGAGAA/C/G/T 
        GGCCC 		1 -- ut31 ese35MN EU EA WA 598
rs11678271,2
A,C,F,H75001105(+) GCGCCA/GATGGC 1 -- ng519Minor allele frequency- G:0.43MN EU EA WA NA 960
rs11678321,2
A,C,F,H75005161(+) CTCTTC/TGTACC 1 -- ut31 ese35Minor allele frequency- T:0.18MN EU EA WA 596
rs11678281,2
A,C,F,H75001333(+) TCTAGA/GCTAAG 1 -- ng5114Minor allele frequency- G:0.11EU EA WA NA 1406
rs43854161,2
A,C,F,H75207149(+) GTACCA/GGCAAG 1 -- ng3112Minor allele frequency- G:0.37EU EA WA NA 1054
--
rs43854151,2
A,C,F,H75207039(+) CATCAA/GAGGAA 1 -- ng314Minor allele frequency- G:0.38EU EA WA 412
rs11678291,2
C,F,H75002954(+) AGACTG/ATTTGC 1 -- ut3113Minor allele frequency- A:0.10NS EU EA WA 944
rs171490231,2
C,F,H75035454(+) GCTCCA/TTGAAG 1 M/K mis115Minor allele frequency- T:0.01NA EU EA WA 1396
--
rs415333461,2
C,F75005096(+) GGTCAA/GATAGT 1 -- ut314Minor allele frequency- G:0.04EU EA WA 420
rs119765161,2
F,H75002446(+) TAAGTC/TGATGA 1 -- ut314Minor allele frequency- T:0.02EU EA WA 420
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HapMap Linkage Disequilibrium images for HIP1 (up to first 250kb)

Disorders & Mutations
for HIP1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 601767   disorders: 176807  

UniProtKB/Swiss-Prot: HIP1_HUMAN, O00291

  • A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic
    leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript
    results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not
    expressed

    • 5 Novoseek disease relationships for HIP1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 77.74 7 15906374 (1), 9616134 (1), 18637945 (1), 11007801 (1) (see all 5)
    leukemia myelomonocytic chronic 76.00 3 9616134 (1), 10428802 (1), 11287412 (1)
    prostate cancer 8.63 7 15899803 (3), 18670643 (1), 16027218 (1)
    cancer 0.00 5 17452370 (1), 14998932 (1), 15899803 (1), 15059611 (1)
    tumors 0.00 7 12781365 (3), 15899803 (2), 17440072 (1)
    About this table

    Human Genome Epidemiology Navigator: HIP1 (1 document)

    Medical News
    for HIP1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for HIP1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/60 PubMed articles for HIP1 gene (see all 60 ):

    Search for HIP1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIP1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 3092 HGNC: 4913 AceView: HIP1.1 Ensembl:ENSG00000127946 euGenes: HUgn3092
    ECgene: HIP1 H-InvDB: HIP1

    Other Databases showing HIP1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing HIP1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for HIP1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for HIP1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for HIP1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for HIP1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for HIP1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for HIP1 Antibodies for HIP1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for HIP1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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