Aliases for HINT3 Gene
Aliases for HINT3 Gene
External Ids for HINT3 Gene
- HGNC: 18468
- Entrez Gene: 135114
- Ensembl: ENSG00000111911
- OMIM: 609998
- UniProtKB: Q9NQE9
Previous GeneCards Identifiers for HINT3 Gene
- GC06P125937
- GC06P126125
- GC06P126258
- GC06P126319
- GC06P126277
- GC06P123854
Summaries for HINT3 Gene
-
Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
GeneCards Summary for HINT3 Gene
HINT3 (Histidine Triad Nucleotide Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and hydrolase activity.
UniProtKB/Swiss-Prot for HINT3 Gene
-
Hydrolyzes phosphoramidate and acyl-adenylate substrates.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HINT3 Gene
Genomics for HINT3 Gene
Regulatory Elements for HINT3 Gene
Enhancers for HINT3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HINT3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HINT3 gene promoter:
Regulatory Element Products
Genomic Location for HINT3 Gene
- Chromosome:
- 6
- Start:
- 125,956,715 bp from pter
- End:
- 125,980,244 bp from pter
- Size:
- 23,530 bases
- Orientation:
- Plus strand
Genomic View for HINT3 Gene
Genes around HINT3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.32 by Ensembl
- 6q22.32 by Entrez Gene
- 6q22.32 by HGNC
HINT3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HINT3 Gene
Proteins for HINT3 Gene
-
Protein details for HINT3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQE9-HINT3_HUMAN
- Recommended name:
- Histidine triad nucleotide-binding protein 3
- Protein Accession:
- Q9NQE9
- B3KQ91
- Q8N0Y9
Protein attributes for HINT3 Gene
- Size:
- 182 amino acids
- Molecular mass:
- 20361 Da
- Quaternary structure:
-
- Forms dimers to octamers and even larger oligomer.
Protein Expression for HINT3 Gene
Post-translational modifications for HINT3 Gene
Other Protein References for HINT3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HINT3
- Novus Biologicals Antibodies for HINT3
- Invitrogen Antibodies for HINT3
- antibodies-online Antibodies for HINT3: See all 17
- Search GeneTex for Antibodies for HINT3
Protein Products
-
OriGene Purified Proteins for HINT3
- Search Origene for MassSpec and Protein Over-expression Lysates for HINT3
- Origene Custom Protein Services for HINT3
- antibodies-online Proteins for HINT3: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HINT3
Assay Products
No data available for DME Specific Peptides for HINT3 Gene
Domains & Families for HINT3 Gene
Protein Domains for HINT3 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HINT3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NQE9- Family:
-
- Belongs to the HINT family.
No data available for Gene Families for HINT3 Gene
Function for HINT3 Gene
Molecular function for HINT3 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=1.5 uM for indolepropinoic acyl-adenylate {ECO:0000269 PubMed:17870088}; KM=22 uM for adenine {ECO:0000269 PubMed:17870088}; KM=29 uM for guanine {ECO:0000269 PubMed:17870088}; KM=32 uM for hypoxanthine {ECO:0000269 PubMed:17870088}; KM=121 uM for uracil {ECO:0000269 PubMed:17870088}; KM=181 uM for cytosine {ECO:0000269 PubMed:17870088}; Note=HINT3 prefers purine over pyrimidine-based substrates.;
- UniProtKB/Swiss-Prot Function:
- Hydrolyzes phosphoramidate and acyl-adenylate substrates.
Enzyme Numbers (IUBMB) for HINT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for HINT3 Gene
- GenomeRNAi human phenotypes for HINT3:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HINT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HINT3 gene
- Search ViGene Biosciences for HINT3
CRISPR Products
-
OriGene CRISPR knockouts for HINT3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HINT3
- GenScript: Design CRISPR guide RNA sequences for HINT3
miRNA for HINT3 Gene
- miRTarBase miRNAs that target HINT3
miRNA Products
- Search ViGene Biosciences for HINT3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HINT3
- Browse OriGene Inhibitory RNA Products For HINT3
-
ViGene Biosciences ready-to-package AAV shRNAs for HINT3 gene
Clone Products
-
OriGene ORF clones in human for HINT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HINT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HINT3
-
ViGene Biosciences adenoviral particle packaged cDNA for HINT3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HINT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HINT3 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HINT3 Gene
Localization for HINT3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HINT3 Gene
- Cytoplasm. Nucleus. Note=Localized as aggregates in the cytoplasm and the nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 4 |
| cytosol | 3 |
| mitochondrion | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for HINT3 Gene
No Data Available
Interacting Proteins for HINT3 Gene
No data available for Pathways by source and SIGNOR curated interactions for HINT3 Gene
Transcripts for HINT3 Gene
mRNA/cDNA for HINT3 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (95) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HINT3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HINT3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HINT3
- GenScript: Design CRISPR guide RNA sequences for HINT3
miRNA Products
- Search ViGene Biosciences for HINT3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HINT3
- Browse OriGene Inhibitory RNA Products For HINT3
-
ViGene Biosciences ready-to-package AAV shRNAs for HINT3 gene
Clone Products
-
OriGene ORF clones in human for HINT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HINT3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||
| SP4: |
Expression for HINT3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Primary Oocyte Primary Follicle
-
Gonad
- Primary Oocyte Primary Follicle
-
Testis (Reproductive System)
This gene is overexpressed in Brain (10.5) and Frontal cortex (8.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HINT3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HINT3 Gene:
HINT3SOURCE GeneReport for Unigene cluster for HINT3 Gene:
Hs.72325Evidence on tissue expression from TISSUES for HINT3 Gene
- Eye(4.1)
- Nervous system(2.7)
Primer Products
-
OriGene qPCR primer pairs for HINT3
-
OriGene qPCR primer pairs and template standards for HINT3
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HINT3 Gene
Orthologs for HINT3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HINT3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HINT3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HINT3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hint3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hint3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HINT3 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| chicken (Gallus gallus) |
Aves | HINT3 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HINT3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hint3 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hint3 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG34015 34 35 |
|
||
| CG15362 35 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007577 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | hint-3 35 |
|
OneToOne |
- Species where no ortholog for HINT3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HINT3 Gene
No data available for Paralogs for HINT3 Gene
Variants for HINT3 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000001503 | -- | 125,955,576(+) | TGGCA(A/T)AACTC | upstream-variant-2KB | |
| rs1000058867 | -- | 125,976,534(+) | TTTTT(G/T)CAAAG | intron-variant | |
| rs1000080182 | -- | 125,957,704(+) | TCAAA(C/T)TATTA | intron-variant | |
| rs1000094350 | -- | 125,978,367(+) | CTAAT(A/G)ACATA | utr-variant-3-prime | |
| rs1000305483 | -- | 125,964,759(+) | ACACA(C/G)ACACA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2732681 | CNV | deletion | 23290073 |
| nsv1019490 | CNV | loss | 25217958 |
| nsv1022677 | CNV | gain | 25217958 |
| nsv1025069 | CNV | loss | 25217958 |
| nsv830796 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.75;
15.78% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HINT3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HINT3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HINT3 Gene
Disorders for HINT3 Gene
Relevant External Links for HINT3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HINT3
No disorders were found for HINT3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HINT3 Gene
Publications for HINT3 Gene
- Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily. (PMID: 17870088) Chou T.-F. … Wagner C.R. (J. Mol. Biol. 2007) 3 4 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. (PMID: 11805111) Bieganowski P. … Brenner C. (J. Biol. Chem. 2002) 2 3 64
- Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. (PMID: 12119013) Brenner C. (Biochemistry 2002) 3 4 64
- Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
Products for HINT3 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for HINT3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HINT3
- Search Origene for MassSpec and Protein Over-expression Lysates for HINT3
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- OriGene qPCR primer pairs and template standards for HINT3
- OriGene qPCR primer pairs for HINT3
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- OriGene ORF clones in human for HINT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for HINT3 in any vector
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- GenScript: Design CRISPR guide RNA sequences for HINT3
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for HINT3
- Novus Biologicals proteins and lysates for HINT3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HINT3: See all 17
- Search antibodies-online for kits
- antibodies-online Proteins for HINT3: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for HINT3
- Search GeneTex for Proteins for HINT3
- ViGene Biosciences adenoviral particle packaged cDNA for HINT3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HINT3 gene
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- Search ViGene Biosciences for HINT3
- Horizon Cell Lines for HINT3
- Cyagen custom Knockout/knockin (KOKI) mouse models for HINT3
- VectorBuilder custom plasmid, inducible vectors for HINT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HINT3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HINT3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer