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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HINT3 Gene

protein-coding GIFtS: 45
GCID: GC06P126277

histidine triad nucleotide binding protein 3

Search for HINT3
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Histidine Triad Nucleotide Binding Protein 3¹ ²		Histidine Triad Nucleotide-Binding Protein 3²
HINT-3² ³		HIT-Like Protein²
FLJ33126¹		EC 3.-.-.-³
HINT4²

External Ids:	HGNC: 18468¹	Entrez Gene: 135114²	Ensembl: ENSG00000111911⁷	OMIM: 609998⁵	UniProtKB: Q9NQE9³

Export aliases for HINT3 gene to outside databases

Previous GC identifers: GC06P125937 GC06P126125 GC06P126258 GC06P126319 GC06P123854

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HINT3:

Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of

ribonucleotides (Brenner, 2002 (PubMed 12119013)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9

Function: Hydrolyzes phosphoramidate and acyl-adenylate substrates

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HINT3 gene promoter:
GATA-3 Nkx5-1 GATA-1 GATA-2 Gfi-1 PPAR-alpha HSF2 FOXO1a IRF-7A FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HINT3 promoter sequence

Search SABiosciences Chromatin IP Primers for HINT3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HINT3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.32 Ensembl cytogenetic band: 6q22.32 HGNC cytogenetic band: 6q22.33

HINT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HINT3 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06P126277: view genomic region (about GC identifiers)

Start:	126,277,861 bp from pter	End:	126,301,390 bp from pter
Size:	23,530 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9 (See protein sequence)

Recommended Name: Histidine triad nucleotide-binding protein 3

Size: 182 amino acids; 20361 Da

Subunit: Forms dimers to octamers and even larger oligomer

Subcellular location: Cytoplasm. Nucleus. Note=Localized as aggregates in the cytoplasm and the nucleus

Secondary accessions: B3KQ91 Q8N0Y9

Explore the universe of human proteins at neXtProt for HINT3: NX_Q9NQE9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQE9

HINT3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_612638.3

ENSEMBL proteins:

ENSP00000229633

Human Recombinant Protein Products for HINT3:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: HINT3 OriGene Protein Over-expression Lysate: HINT3 OriGene Custom Protein Services for HINT3
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	Novus Biologicals HINT3 Protein Novus Biologicals HINT3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HINT3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005739	mitochondrion	IDA	--

HINT3 for ontologies About GeneDecksing

HINT3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	GenScript Custom Superior Antibodies Services for HINT3
	Novus Biologicals HINT3 Antibody
	Abcam antibodies for HINT3
	Uscn Antibodies for HINT3
	Search ThermoFisher Antibodies for HINT3

Assay Products for HINT3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HINT3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HINT3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HINT3 for domains About GeneDecksing

2 InterPro domains/families:

IPR001310 Histidine_triad_HIT

IPR011146 HIT-like

Graphical View of Domain Structure for InterPro Entry Q9NQE9

ProtoNet protein and cluster: Q9NQE9

1 Blocks protein family: IPB001310 Histidine triad (HIT) protein

UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9

Similarity: Belongs to the HINT family

Similarity: Contains 1 HIT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HINT3_HUMAN, Q9NQE9

Function: Hydrolyzes phosphoramidate and acyl-adenylate substrates

Biophysicochemical properties: Kinetic parameters: KM=1.5 uM for indolepropinoic acyl-adenylate; KM=22 uM for adenine;

KM=29 uM for guanine; KM=32 uM for hypoxanthine; KM=121 uM for uracil; KM=181 uM for cytosine; Note=HINT3 prefers

purine over pyrimidine-based substrates;

Enzyme Number (IUBMB): EC 3.-.-.-¹

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016787	hydrolase activity	IEA	--

HINT3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for HINT3:

Increased homologous recombina

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HINT3

miRNA Products:		OriGene 3'-UTR Clone: HINT3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HINT3
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate HINT3:
		hsa-miR-141* hsa-miR-27a hsa-miR-3065-5p hsa-miR-885-5p hsa-miR-3647-3p hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: HINT3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HINT3 (see all 4) OriGene shRNA RFP: HINT3 OriGene siRNA: HINT3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HINT3
		Sirion Biotech Custom design and validation of potent shRNA sequences against HINT3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HINT3
			Sirion Biotech Customized adenovirus for overexpression of HINT3 Sirion Biotech Customized adenovirus for potent knockdown of HINT3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HINT3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HINT3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HINT3 (NM_138571)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HINT3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HINT3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HINT3
		Search LifeMap BioReagents cell lines for HINT3
		Sirion Biotech Customized stable knockdown cell line services for HINT3 Sirion Biotech Customized inducible knockdown cell line services for HINT3 Sirion Biotech Customized stable overexpressing cell line services for HINT3 Sirion Biotech Customized inducible overexpressing cell line services for HINT3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINT3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HINT3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for HINT3 (ENSP00000229633⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HINT3
Search CenterWatch for drugs/clinical trials and news about HINT3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HINT3 gene:

NM_138571.4

Unigene Cluster for HINT3:

Histidine triad nucleotide binding protein 3

Hs.72325 [show with all ESTs]

Unigene Representative Sequence: BX647228

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000229633(uc003qal.4 uc010keu.3)

miRNA Products:		OriGene 3'-UTR Clone: HINT3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HINT3
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate HINT3:
		hsa-miR-141* hsa-miR-27a hsa-miR-3065-5p hsa-miR-885-5p hsa-miR-3647-3p hsa-miR-27b
		SwitchGear 3'UTR luciferase reporter plasmid: HINT3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HINT3 (see all 4) OriGene shRNA RFP: HINT3 OriGene siRNA: HINT3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HINT3
		Sirion Biotech Custom design and validation of potent shRNA sequences against HINT3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HINT3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HINT3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HINT3 (NM_138571)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HINT3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HINT3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HINT3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HINT3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HINT3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HINT3

Additional cDNA sequence:

AJ420577.1 AK056858.1 AK057688.1 AK309857.1 AY035387.1 AY035388.1 AY486460.1 AY486461.1

BC015732.1 BX647228.1

3 DOTS entries:

DT.107711 DT.95272692 DT.121322042

24/95 AceView cDNA sequences (see all 95):

AY035387 CR616633 AA746635 AA614784 BC015732 AA776796 AW137584 BX092395

BU735345 CD679358 AW614771 AI613268 AY486460 BG720989 AK056858 AI214398

AY486461 AI039638 BG575292 BF694956 BX501107 AI241517 CD653835 BX369108

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for HINT3 About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b
SP1:									-
SP2:							-		-
SP3:									-
SP4:

ECgene alternative splicing isoforms for HINT3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HINT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTGATACT

About this image

HINT3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Primary Follicle

Primary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HINT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HINT3

SOURCE GeneReport for Unigene cluster: Hs.72325

SABiosciences Custom PCR Arrays for HINT3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HINT3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat HINT3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HINT3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HINT3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINT3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for HINT3 gene from 8/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hint3^{1 , 5}	histidine triad nucleotide binding protein 3^{1, 5}	76.04(n)¹ 70.62(a)¹		10 (17.10 cM)⁵ 66847¹ NM_025798.3¹ NP_080074.1¹ 30608141⁵
chicken (Gallus gallus)	Aves	HINT3¹	histidine triad nucleotide binding protein 3	71.7(n) 66.19(a)		769579 XM_001232865.2 XP_001232866.1
lizard (Anolis carolinensis)	Reptilia	HINT3⁶	--	63(a)	1 ↔ 1	1(180388006-180393826)
zebrafish (Danio rerio)	Actinopterygii	hint3¹	histidine triad nucleotide binding protein 3	60.89(n) 58(a)		796590 XM_001334725.3 XP_001334761.2
fruit fly (Drosophila melanogaster)	Insecta	CG34015¹	CG34015	51.97(n) 42.52(a)		3885570 NM_001038759.2 NP_001033848.1
worm (Caenorhabditis elegans)	Secernentea	hint-3⁶	HIstidiNe Triad nucleotide-binding protein family ...	25(a)	1 ↔ 1	V(7760447-7761594)
thale cress (Arabidopsis thaliana)	eudicotyledons	HINT4⁶	protein histidine triad nucleotide-binding 4	37(a)	1 ↔ 1	4(9334622-9335968)
rice (Oryza sativa)	Liliopsida	--	histidine triad family protein, putative, expresse...	32(a)	1 ↔ 1	4(26567071-26572164)

ENSEMBL Gene Tree for HINT3 (if available)
TreeFam Gene Tree for HINT3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs116387704^1,2	C,F	--	126275863(+)	`ATTAGA/GAAATT`	1	--	us2k¹		1		WA	118
rs113207959^1,2		--	126275944(+)	`GAGGAC/GGATTT`	1	--	us2k¹		1		CSA	1
rs192825044^1,2		--	126275985(+)	`AACATC/TCGCTG`	1	--	us2k¹		0	--	--	--	--
rs4897162^1,2	C,F,A,H	--	126275986(+)	`ACATCT/CGCTGA`	1	--	us2k¹		9		NS EA NA WA	774
rs184949149^1,2		--	126276073(+)	`GAAGCA/GTATTA`	1	--	us2k¹		0	--	--	--	--
rs4897163^1,2	C,F,A	--	126276262(+)	`ACAGAC/TAGAAA`	1	--	us2k¹		6		NA WA CSA	129
rs150325558^1,2		--	126276273(+)	`AACAGG/TCAGTT`	1	--	us2k¹		0	--	--	--	--
rs137855835^1,2		--	126276456(+)	`ATAAGC/TACATA`	1	--	us2k¹		0	--	--	--	--
rs17053717^1,2	C,F,H	--	126276472(+)	`CTATAA/GGATAC`	1	--	us2k¹		8		NA NS EA WA	670
rs187872374^1,2		--	126276512(+)	`GAAAAC/TCTGTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HINT3 (126277861 - 126301390 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HINT3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HINT3

DNA2.0 Custom Variant and Variant Library Synthesis for HINT3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HINT3 for disorders About MalaCards

HINT3 for disorders About GeneDecksing

OMIM gene information: 609998 OMIM disorders: --

Export disorders for HINT3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HINT3 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with HINT3)

Utopia: connect your pdf to the dynamic
world of online information

Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily. (PubMed id 17870088)^{1, 2, 9} Chou T.F....Wagner C.R. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. (PubMed id 12119013)^{1, 2} Brenner C. (2002)
Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. (PubMed id 11805111)^{1, 3} Bieganowski P....Brenner C. (2002)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 135114	HGNC: 18468	AceView: HINT3	Ensembl:ENSG00000111911	euGenes: HUgn135114
ECgene: HINT3	H-InvDB: HINT3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HINT3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HINT3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for HINT3 gene:
Search GeneIP for patents involving HINT3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	Browse OriGene Antibodies		OriGene shRNA RFP for HINT3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HINT3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HINT3
	OriGene Protein Over-expression Lysate for HINT3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for HINT3		OriGene 3'-UTR Clone for HINT3
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HINT3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HINT3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for HINT3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for HINT3		OriGene Custom Protein Services for HINT3
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HINT3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HINT3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HINT3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HINT3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HINT3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HINT3

	GenScript Custom Purified and Recombinant Proteins Services for HINT3		GenScript cDNA clones with any tag delivered in your preferred vector for HINT3
	GenScript Custom Assay Services for HINT3		GenScript Custom Superior Antibodies Services for HINT3
	GenScript Custom overexpressing Cell Line Services for HINT3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in HINT3 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	HINT3 antibodies
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	HINT3 lysates

	Antibodies for HINT3
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HINT3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for HINT3

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINT3

	SwitchGear 3'UTR luciferase reporter plasmids for HINT3
	SwitchGear Promoter luciferase reporter plasmids for HINT3

Search ThermoFisher Antibodies for HINT3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HINT3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HINT3

Sirion Biotech Customized:

	stable knockdown cell line services for HINT3
	inducible knockdown cell line services for HINT3
	design and validation of potent shRNA sequences against HINT3
	adenovirus for potent knockdown of HINT3
	adenovirus for overexpression of HINT3
	stable overexpressing cell line services for HINT3
	inducible overexpressing cell line services for HINT3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes HINT3 gene at Home site.

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HINT3 Gene

histidine triad nucleotide binding protein 3

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HINT3 Gene

histidine triad nucleotide binding protein 3

Aliasesfor HINT3 gene

Summariesfor HINT3 gene

Genomic Viewsfor HINT3 gene

Proteinsfor HINT3 gene

Protein Domains /Familiesfor HINT3 gene

Functionfor HINT3 gene

Pathways & Interactionsfor HINT3 gene

Drugs & Compoundsfor HINT3 gene

Transcriptsfor HINT3 gene

Expression for HINT3 gene

Orthologsfor HINT3 gene

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Genomic Variantsfor HINT3 gene

Disorders / Diseasesfor HINT3 gene

Publicationsfor HINT3 gene

External Searches for HINT3 gene

Genome Databases showing HINT3 gene

Other Databases showing HINT3 gene

Specialized Databases showing HINT3 gene

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Aliases
for HINT3 gene

Summaries
for HINT3 gene

Genomic Views
for HINT3 gene

Proteins
for HINT3 gene

Protein Domains /
Families
for HINT3 gene

Function
for HINT3 gene

Pathways & Interactions
for HINT3 gene

Drugs & Compounds
for HINT3 gene

Transcripts
for HINT3 gene

Expression
for HINT3 gene

Orthologs
for HINT3 gene

Paralogs
for HINT3 gene

Genomic Variants
for HINT3 gene

Disorders / Diseases
for HINT3 gene

Publications
for HINT3 gene

Intellectual Property
for HINT3 gene

Products
for HINT3 gene