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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HINT3 Gene

protein-coding   GIFtS: 47
GCID: GC06P126277

Histidine Triad Nucleotide Binding Protein 3

  Search for HINT3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Histidine Triad Nucleotide Binding Protein 31 2
HINT-32 3
HINT42
Histidine Triad Nucleotide-Binding Protein 32
HIT-Like Protein2
EC 3.-.-.-3

External Ids:    HGNC: 184681   Entrez Gene: 1351142   Ensembl: ENSG000001119117   OMIM: 6099985   UniProtKB: Q9NQE93   

Export aliases for HINT3 gene to outside databases

Previous GC identifers: GC06P125937 GC06P126125 GC06P126258 GC06P126319 GC06P123854


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HINT3 Gene:
Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the
alpha-phosphate of ribonucleotides (Brenner, 2002 (PubMed 12119013)).(supplied by OMIM, Mar 2008)

GeneCards Summary for HINT3 Gene: 
HINT3 (histidine triad nucleotide binding protein 3) is a protein-coding gene. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9
Function: Hydrolyzes phosphoramidate and acyl-adenylate substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_025741.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HINT3 gene promoter:
         GATA-3   Nkx5-1   GATA-1   GATA-2   Gfi-1   PPAR-alpha   HSF2   FOXO1a   IRF-7A   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHINT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HINT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HINT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.32   Ensembl cytogenetic band:  6q22.32   HGNC cytogenetic band: 6q22.33

HINT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HINT3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P126277:  view genomic region     (about GC identifiers)

Start:
126,277,861 bp from pter      End:
126,301,390 bp from pter
Size:
23,530 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9 (See protein sequence)
Recommended Name: Histidine triad nucleotide-binding protein 3  
Size: 182 amino acids; 20361 Da
Subunit: Forms dimers to octamers and even larger oligomer
Subcellular location: Cytoplasm. Nucleus. Note=Localized as aggregates in the cytoplasm and the nucleus
Secondary accessions: B3KQ91 Q8N0Y9

Explore the universe of human proteins at neXtProt for HINT3: NX_Q9NQE9

Explore proteomics data for HINT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQE9

  • HINT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HINT3 Protein Expression
    REFSEQ proteins: NP_612638.3  
    ENSEMBL proteins: 
     ENSP00000229633  

    Human Recombinant Protein Products for HINT3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for HINT3
    OriGene MassSpec for HINT3 
    OriGene Custom Protein Services for HINT3
    GenScript Custom Purified and Recombinant Proteins Services for HINT3
    Novus Biologicals HINT3 Protein
    Novus Biologicals HINT3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HINT3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    HINT3 for ontologies           About GeneDecksing



    HINT3 Antibody Products: 
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    Abcam antibodies for HINT3
    Cloud-Clone Corp. Antibodies for HINT3 
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    Assay Products for HINT3: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HINT3 
    Cloud-Clone Corp. CLIAs for HINT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001310 Histidine_triad_HIT
     IPR011146 HIT-like

    Graphical View of Domain Structure for InterPro Entry Q9NQE9

    ProtoNet protein and cluster: Q9NQE9

    1 Blocks protein domain: IPB001310 Histidine triad (HIT) protein

    UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9
    Similarity: Belongs to the HINT family
    Similarity: Contains 1 HIT domain


    HINT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HINT3_HUMAN, Q9NQE9
    Function: Hydrolyzes phosphoramidate and acyl-adenylate substrates
    Biophysicochemical properties: Kinetic parameters: KM=1.5 uM for indolepropinoic acyl-adenylate; KM=22 uM for
    adenine; KM=29 uM for guanine; KM=32 uM for hypoxanthine; KM=121 uM for uracil; KM=181 uM for cytosine;
    Note=HINT3 prefers purine over pyrimidine-based substrates;

         Enzyme Number (IUBMB): EC 3.-.-.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0016787hydrolase activity IEA--
         
    HINT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HINT3:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HINT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HINT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HINT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HINT3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HINT3
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HINT3:
    hsa-miR-141* hsa-miR-27a hsa-miR-3065-5p hsa-miR-885-5p hsa-miR-3647-3p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidHINT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HINT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HINT3

    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of HINT3 

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    GenScript Custom overexpressing Cell Line Services for HINT3
    Search LifeMap BioReagents cell lines for HINT3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINT3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HINT3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HINT3 (ENSP000002296334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HINT3

    Search CenterWatch for drugs/clinical trials and news about HINT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HINT3 gene: 
    NM_138571.4  

    Unigene Cluster for HINT3:

    Histidine triad nucleotide binding protein 3
    Hs.72325  [show with all ESTs]
    Unigene Representative Sequence: BX647228
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229633(uc003qal.4 uc010keu.3)
    miRNA
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    6 QIAGEN miScript miRNA Assays for microRNAs that regulate HINT3:
    hsa-miR-141* hsa-miR-27a hsa-miR-3065-5p hsa-miR-885-5p hsa-miR-3647-3p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidHINT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HINT3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HINT3
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HINT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HINT3
    Sirion Biotech Customized lentivirus for stable overexpression of HINT3 
                         Customized lentivirus expression plasmids for stable overexpression of HINT3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HINT3
    OriGene qSTAR qPCR primer pairs in human, mouse for HINT3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HINT3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HINT3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HINT3

    Additional mRNA sequence: 

    AJ420577.1 AK056858.1 AK057688.1 AK309857.1 AY035387.1 AY035388.1 AY486460.1 AY486461.1 
    BC015732.1 BX647228.1 

    3 DOTS entries:

    DT.107711  DT.95272692  DT.121322042 

    24/95 AceView cDNA sequences (see all 95):

    BC015732 BU735345 AY035387 AA776796 CD679358 AW137584 BX092395 CR616633 
    AI613268 AY486460 AA614784 AW614771 AA746635 BX647228 AI689320 AY035388 
    BG547156 AI241517 AI926681 AW503739 AI860677 BM821686 BM696291 AW731710 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HINT3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                          -                                             
    SP2:                    -     -                                             
    SP3:                          -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for HINT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HINT3 expression in normal human tissues (normalized intensities)      HINT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGATACT
    HINT3 Expression
    About this image


    HINT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Endothelium (Cardiovascular System)
             Umbilical cord blood-derived endothelial progenitor cells
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Brain (Nervous System)
             primary visual cortex   

    See HINT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HINT3

    SOURCE GeneReport for Unigene cluster: Hs.72325
        SABiosciences Custom PCR Arrays for HINT3
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HINT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HINT3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hint31 , 5 histidine triad nucleotide binding protein 31, 5 76.04(n)1
    70.62(a)1
      10 (17.10 cM)5
    668471  NM_025798.31  NP_080074.11 
     306081415 
    chicken
    (Gallus gallus)
    Aves HINT31 histidine triad nucleotide binding protein 3 71.7(n)
    66.19(a)
      769579  XM_001232865.2  XP_001232866.1 
    lizard
    (Anolis carolinensis)
    Reptilia HINT36
    Uncharacterized protein
    63(a)
    1 ↔ 1
    1(180388006-180393826)
    zebrafish
    (Danio rerio)
    Actinopterygii hint31 histidine triad nucleotide binding protein 3 60.89(n)
    58(a)
      796590  XM_001334725.3  XP_001334761.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG340151 CG34015 51.97(n)
    42.52(a)
      3885570  NM_001038759.2  NP_001033848.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hint-36
    Protein HINT-3, isoform b
    26(a)
    1 ↔ 1
    V(7760466-7761613)


    ENSEMBL Gene Tree for HINT3 (if available)
    TreeFam Gene Tree for HINT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/498 SNPs in HINT3 are shown (see all 498)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163877041,2
    C,F--126275863(+) ATTAGA/GAAATT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1132079591,2
    F--126275944(+) GAGGAC/GGATTT 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1928250441,2
    --126275985(+) AACATC/TCGCTG 1 -- us2k10--------
    rs48971621,2
    C,F,A,H--126275986(+) ACATCT/CGCTGA 1 -- us2k19Minor allele frequency- C:0.44NS EA NA WA 774
    rs1997365751,2
    C--126276048(+) AGTTGC/G/TGGGGA 1 -- us2k10--------
    rs1849491491,2
    --126276073(+) GAAGCA/GTATTA 1 -- us2k10--------
    rs48971631,2
    C,F,A--126276262(+) ACAGAC/TAGAAA 1 -- us2k16Minor allele frequency- T:0.49NA WA CSA 129
    rs1503255581,2
    --126276273(+) AACAGG/TCAGTT 1 -- us2k10--------
    rs1378558351,2
    --126276456(+) ATAAGC/TACATA 1 -- us2k10--------
    rs170537171,2
    C,F,H--126276472(+) CTATAA/GGATAC 1 -- us2k18Minor allele frequency- G:0.05NA NS EA WA 670

    HapMap Linkage Disequilibrium report for HINT3 (126277861 - 126301390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HINT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732681CNV Deletion23290073
    nsv830796CNV Loss17160897
    nsv886636CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HINT3
    DNA2.0 Custom Variant and Variant Library Synthesis for HINT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HINT3 for disorders           About MalaCards
    OMIM gene information: 609998    OMIM disorders: --


    HINT3 for disorders           About GeneDecksing


    Export disorders for HINT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HINT3 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with HINT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily. (PubMed id 17870088)1, 2, 9 Chou T.F....Wagner C.R. (2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. (PubMed id 12119013)1, 2 Brenner C. (2002)
    4. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. (PubMed id 11805111)1, 3 Bieganowski P....Brenner C. (2002)
    5. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 135114 HGNC: 18468 AceView: HINT3 Ensembl:ENSG00000111911 euGenes: HUgn135114
    ECgene: HINT3 H-InvDB: HINT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HINT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HINT3 gene:
    Search GeneIP for patents involving HINT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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