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HINT3 Gene

protein-coding   GIFtS: 50
GCID: GC06P126277

Histidine Triad Nucleotide Binding Protein 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histidine Triad Nucleotide Binding Protein 31 2
HINT-32 3
HINT42
Histidine Triad Nucleotide-Binding Protein 32
HIT-Like Protein2
EC 3.-.-.-3

External Ids:    HGNC: 184681   Entrez Gene: 1351142   Ensembl: ENSG000001119117   OMIM: 6099985   UniProtKB: Q9NQE93   

Export aliases for HINT3 gene to outside databases

Previous GC identifers: GC06P125937 GC06P126125 GC06P126258 GC06P126319 GC06P123854


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HINT3 Gene:
Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the
alpha-phosphate of ribonucleotides (Brenner, 2002 (PubMed 12119013)).(supplied by OMIM, Mar 2008)

GeneCards Summary for HINT3 Gene:
HINT3 (histidine triad nucleotide binding protein 3) is a protein-coding gene. Diseases associated with HINT3 include malaria. GO annotations related to this gene include hydrolase activity and nucleotide binding.

UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9
Function: Hydrolyzes phosphoramidate and acyl-adenylate substrates




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HINT3 gene promoter:
         GATA-3   Nkx5-1   GATA-1   GATA-2   Gfi-1   PPAR-alpha   HSF2   FOXO1a   IRF-7A   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHINT3 promoter sequence
   Search Chromatin IP Primers for HINT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HINT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.32   Ensembl cytogenetic band:  6q22.32   HGNC cytogenetic band: 6q22.33

HINT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HINT3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P126277:  view genomic region     (about GC identifiers)

Start:
126,277,861 bp from pter      End:
126,301,390 bp from pter
Size:
23,530 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9 (See protein sequence)
Recommended Name: Histidine triad nucleotide-binding protein 3  
Size: 182 amino acids; 20361 Da
Subunit: Forms dimers to octamers and even larger oligomer
Secondary accessions: B3KQ91 Q8N0Y9

Explore the universe of human proteins at neXtProt for HINT3: NX_Q9NQE9

Explore proteomics data for HINT3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys78, Lys115, Lys179
  • Modification sites at PhosphoSitePlus

  • See HINT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612638.3  
    ENSEMBL proteins: 
     ENSP00000229633  

    HINT3 Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for HINT3

    HINT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for HINT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001310 Histidine_triad_HIT
     IPR011146 HIT-like

    Graphical View of Domain Structure for InterPro Entry Q9NQE9

    ProtoNet protein and cluster: Q9NQE9

    1 Blocks protein domain: IPB001310 Histidine triad (HIT) protein

    UniProtKB/Swiss-Prot: HINT3_HUMAN, Q9NQE9
    Similarity: Belongs to the HINT family
    Similarity: Contains 1 HIT domain


    HINT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HINT3_HUMAN, Q9NQE9
    Function: Hydrolyzes phosphoramidate and acyl-adenylate substrates
    Biophysicochemical properties: Kinetic parameters: KM=1.5 uM for indolepropinoic acyl-adenylate; KM=22 uM for
    adenine; KM=29 uM for guanine; KM=32 uM for hypoxanthine; KM=121 uM for uracil; KM=181 uM for cytosine;
    Note=HINT3 prefers purine over pyrimidine-based substrates;

         Enzyme Number (IUBMB): EC 3.-.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003824catalytic activity ----
    GO:0016787hydrolase activity IEA--
         
    HINT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HINT3:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HINT3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HINT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HINT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target HINT3:
    hsa-mir-192-5p (MIRT026326), hsa-mir-215-5p (MIRT024582), hsa-mir-30a-5p (MIRT028522)

    Block miRNA regulation of human, mouse, rat HINT3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate HINT3:
    hsa-miR-141* hsa-miR-27a hsa-miR-3065-5p hsa-miR-885-5p hsa-miR-3647-3p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidHINT3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat HINT3

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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HINT3_HUMAN, Q9NQE9: Cytoplasm. Nucleus. Note=Localized as aggregates in the cytoplasm and the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol3
    extracellular3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    HINT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HINT3
    Interactions:

        Search GeneGlobe Interaction Network for HINT3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HINT3 (ENSP000002296334) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HINT3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HINT3 gene: 
    NM_138571.4  

    Unigene Cluster for HINT3:

    Histidine triad nucleotide binding protein 3
    Hs.72325  [show with all ESTs]
    Unigene Representative Sequence: BX647228
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000229633(uc003qal.4 uc010keu.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat HINT3 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate HINT3:
    hsa-miR-141* hsa-miR-27a hsa-miR-3065-5p hsa-miR-885-5p hsa-miR-3647-3p hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidHINT3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HINT3
    Predesigned siRNA for gene silencing in human, mouse, rat HINT3
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    GenScript: all cDNA clones in your preferred vector: HINT3 (NM_138571)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HINT3
    Primer
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    OriGene qPCR primer pairs and template standards for HINT3
    OriGene qSTAR qPCR primer pairs in human, mouse for HINT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HINT3
      QuantiTect SYBR Green Assays in human, mouse, rat HINT3
      QuantiFast Probe-based Assays in human, mouse, rat HINT3

    Additional mRNA sequence: 

    AJ420577.1 AK056858.1 AK057688.1 AK309857.1 AY035387.1 AY035388.1 AY486460.1 AY486461.1 
    BC015732.1 BX647228.1 

    3 DOTS entries:

    DT.107711  DT.95272692  DT.121322042 

    Selected AceView cDNA sequences (see all 95):

    AY486460 CR616633 BX092395 AA776796 AW137584 AI613268 AY035387 AW614771 
    BC015732 BU735345 AA614784 AA746635 CD679358 AI689320 AW673563 BF694956 
    AW664075 BU622119 BI835723 AY486461 AI432344 BG751920 CD511994 AY035388 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HINT3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b
    SP1:                          -                                             
    SP2:                    -     -                                             
    SP3:                          -                                             
    SP4:                                                                        


    ECgene alternative splicing isoforms for HINT3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HINT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGATACT
    HINT3 Expression
    About this image


    HINT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Testis (Reproductive System)
    HINT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HINT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72325
        Custom PCR Arrays for HINT3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HINT3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hint31 , 5 histidine triad nucleotide binding protein 31, 5 76.04(n)1
    70.62(a)1
      10 (17.10 cM)5
    668471  NM_025798.31  NP_080074.11 
     306081415 
    chicken
    (Gallus gallus)
    Aves HINT31 histidine triad nucleotide binding protein 3 71.7(n)
    66.19(a)
      769579  XM_001232865.3  XP_001232866.1 
    lizard
    (Anolis carolinensis)
    Reptilia HINT36
    histidine triad nucleotide binding protein 3
    63(a)
    1 ↔ 1
    1(180388006-180393826)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hint31 histidine triad nucleotide binding protein 3 65.78(n)
    62.67(a)
      733971  NM_001045681.1  NP_001039146.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hint31 histidine triad nucleotide binding protein 3 60.44(n)
    58(a)
      796590  XM_001334725.4  XP_001334761.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG340151 CG34015 52.49(n)
    42.52(a)
      3885570  NM_001038759.2  NP_001033848.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hint-36
    Protein HINT-3, isoform b
    26(a)
    1 ↔ 1
    V(7760466-7761613) WBGene00016150


    ENSEMBL Gene Tree for HINT3 (if available)
    TreeFam Gene Tree for HINT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HINT3 (see all 498)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163877041,2
    C,F--126275863(+) ATTAGA/GAAATT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1132079591,2
    F--126275944(+) GAGGAC/GGATTT 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1928250441,2
    --126275985(+) AACATC/TCGCTG 1 -- us2k10--------
    rs48971621,2
    C,F,A,H--126275986(+) ACATCT/CGCTGA 1 -- us2k19Minor allele frequency- C:0.44NS EA NA WA 774
    rs1997365751,2
    C--126276048(+) AGTTGC/G/TGGGGA 1 -- us2k10--------
    rs1849491491,2
    --126276073(+) GAAGCA/GTATTA 1 -- us2k10--------
    rs48971631,2
    C,F,A--126276262(+) ACAGAC/TAGAAA 1 -- us2k16Minor allele frequency- T:0.49NA WA CSA 129
    rs1503255581,2
    --126276273(+) AACAGG/TCAGTT 1 -- us2k10--------
    rs1378558351,2
    --126276456(+) ATAAGC/TACATA 1 -- us2k10--------
    rs170537171,2
    C,F,H--126276472(+) CTATAA/GGATAC 1 -- us2k18Minor allele frequency- G:0.05NA NS EA WA 670

    HapMap Linkage Disequilibrium report for HINT3 (126277861 - 126301390 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HINT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732681CNV Deletion23290073
    nsv830796CNV Loss17160897
    nsv886636CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HINT3
    DNA2.0 Custom Variant and Variant Library Synthesis for HINT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609998    OMIM disorders: --

    1 disease for HINT3:    
    About MalaCards
    malaria


    HINT3 for disorders           About GeneDecksing


    Export disorders for HINT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HINT3 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with HINT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evidence that human histidine triad nucleotide binding protein 3 (Hint3) is a distinct branch of the histidine triad (HIT) superfamily. (PubMed id 17870088)1, 2, 9 Chou T.-F.... Wagner C.R. (J. Mol. Biol. 2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. (PubMed id 12119013)1, 2 Brenner C. (Biochemistry 2002)
    4. Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. (PubMed id 11805111)1, 3 Bieganowski P....Brenner C. (J. Biol. Chem. 2002)
    5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 135114 HGNC: 18468 AceView: HINT3 Ensembl:ENSG00000111911 euGenes: HUgn135114
    ECgene: HINT3 H-InvDB: HINT3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HINT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HINT3 gene:
    Search GeneIP for patents involving HINT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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