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Aliases for HINT2 Gene

Subcategory (RNA class) for HINT2 Gene


Aliases for HINT2 Gene

  • Histidine Triad Nucleotide Binding Protein 2 2 3
  • PKCI-1-Related HIT Protein 3 4
  • HIT-17kDa 3 4
  • HINT-2 3 4
  • HINT-3 3 4
  • Histidine Triad Nucleotide-Binding Protein 2, Mitochondrial 3
  • Protein Kinase C Inhibitor-2 3
  • EC 3.-.-.- 4
  • HIT-17 3

External Ids for HINT2 Gene

ORGUL Members for HINT2 Gene

Previous GeneCards Identifiers for HINT2 Gene

  • GC09M036125
  • GC09M035982
  • GC09M035802

Summaries for HINT2 Gene

Entrez Gene Summary for HINT2 Gene

  • Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HINT2 Gene

HINT2 (Histidine Triad Nucleotide Binding Protein 2) is a Protein Coding gene, and is affiliated with the lncRNA class. GO annotations related to this gene include nucleotide binding and hydrolase activity. An important paralog of this gene is HINT1.

UniProtKB/Swiss-Prot for HINT2 Gene

  • Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HINT2 Gene

Genomics for HINT2 Gene

Regulatory Elements for HINT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HINT2 Gene

35,812,960 bp from pter
35,815,479 bp from pter
2,520 bases
Minus strand

Genomic View for HINT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HINT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HINT2 Gene

Proteins for HINT2 Gene

  • Protein details for HINT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histidine triad nucleotide-binding protein 2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5TCW3

    Protein attributes for HINT2 Gene

    163 amino acids
    Molecular mass:
    17162 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HINT2 Gene

neXtProt entry for HINT2 Gene

Proteomics data for HINT2 Gene at MOPED

Post-translational modifications for HINT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HINT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HINT2 Gene

Domains for HINT2 Gene

Protein Domains for HINT2 Gene

Suggested Antigen Peptide Sequences for HINT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BX68
  • Contains 1 HIT domain.
  • Belongs to the HINT family.
genes like me logo Genes that share domains with HINT2: view

No data available for Gene Families for HINT2 Gene

Function for HINT2 Gene

Molecular function for HINT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=128 uM for adenosine 5-O-p-nitrophenylphosphoramidate {ECO:0000269 PubMed:16762638};
UniProtKB/Swiss-Prot Function: Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.

Enzyme Numbers (IUBMB) for HINT2 Gene

Gene Ontology (GO) - Molecular Function for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003824 catalytic activity --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with HINT2: view

Animal Model Products

CRISPR Products

miRNA for HINT2 Gene

miRTarBase miRNAs that target HINT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HINT2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HINT2 Gene

Localization for HINT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HINT2 Gene


Subcellular locations from

Jensen Localization Image for HINT2 Gene COMPARTMENTS Subcellular localization image for HINT2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with HINT2: view

Pathways for HINT2 Gene

SuperPathways for HINT2 Gene

No Data Available

Interacting Proteins for HINT2 Gene

Gene Ontology (GO) - Biological Process for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IEA --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with HINT2: view

No data available for Pathways by source for HINT2 Gene

Transcripts for HINT2 Gene

Unigene Clusters for HINT2 Gene

Histidine triad nucleotide binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HINT2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HINT2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - -
SP2: -
SP4: - -
SP6: -

Relevant External Links for HINT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HINT2 Gene

mRNA expression in normal human tissues for HINT2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HINT2 Gene

SOURCE GeneReport for Unigene cluster for HINT2 Gene Hs.70573

mRNA Expression by UniProt/SwissProt for HINT2 Gene

Tissue specificity: High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.
genes like me logo Genes that share expressions with HINT2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HINT2 Gene

Orthologs for HINT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HINT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HINT2 35
  • 99.8 (n)
  • 100 (a)
HINT2 36
  • 100 (a)
(Bos Taurus)
Mammalia HINT2 35
  • 90.89 (n)
  • 94 (a)
HINT2 36
  • 93 (a)
(Canis familiaris)
Mammalia HINT2 35
  • 89.78 (n)
  • 88.34 (a)
HINT2 36
  • 88 (a)
(Mus musculus)
Mammalia Hint2 35
  • 85.55 (n)
  • 86.71 (a)
Hint2 16
Hint2 36
  • 86 (a)
(Monodelphis domestica)
Mammalia HINT2 36
  • 85 (a)
(Rattus norvegicus)
Mammalia Hint2 35
  • 86.25 (n)
  • 87.41 (a)
(Gallus gallus)
Aves HINT2 36
  • 65 (a)
LOC100859112 35
  • 68.14 (n)
  • 72.79 (a)
(Anolis carolinensis)
Reptilia HINT2 36
  • 72 (a)
(Danio rerio)
Actinopterygii Dr.16548 35
hint2 35
  • 64.86 (n)
  • 68.22 (a)
hint2 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2862 36
  • 51 (a)
CG2862 37
  • 60 (a)
(Caenorhabditis elegans)
Secernentea hint-1 36
  • 52 (a)
F21C3.3 37
  • 55 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HINT 2 35
  • 57.72 (n)
  • 53.66 (a)
(Zea mays)
Liliopsida Zm.2313 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1686 36
  • 50 (a)
Species with no ortholog for HINT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HINT2 Gene

Gene Tree for HINT2 (if available)
Gene Tree for HINT2 (if available)

Paralogs for HINT2 Gene

Paralogs for HINT2 Gene

Selected SIMAP similar genes for HINT2 Gene using alignment to 1 proteins: Pseudogenes for HINT2 Gene

genes like me logo Genes that share paralogs with HINT2: view

Variants for HINT2 Gene

Sequence variations from dbSNP and Humsavar for HINT2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs3808864 -- 35,815,616(-) ACAAA(A/C)ACAAA upstream-variant-2KB
rs3808865 -- 35,815,468(-) AGGTG(A/G)CGGAG upstream-variant-2KB, utr-variant-5-prime
rs3834891 -- 35,814,590(+) CAAGA(-/AGA)GAAAG intron-variant
rs4879928 -- 35,815,314(+) TTAAT(A/G)GAGCC upstream-variant-2KB, utr-variant-5-prime
rs4879929 -- 35,815,359(+) CACAA(C/T)TCTGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HINT2 Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294

Relevant External Links for HINT2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HINT2 Gene

Disorders for HINT2 Gene

Relevant External Links for HINT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HINT2: view

No data available for UniProtKB/Swiss-Prot for HINT2 Gene

Publications for HINT2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. (PMID: 16762638) Martin J. … Dufour J.-F. (Gastroenterology 2006) 3 4
  3. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. (PMID: 18653718) Lenglet S. … Rossier M.F. (Endocrinology 2008) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for HINT2 Gene

  • Addgene plasmids for HINT2

Sources for HINT2 Gene

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