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Aliases for HINT2 Gene

Subcategory (RNA class) for HINT2 Gene


Aliases for HINT2 Gene

  • Histidine Triad Nucleotide Binding Protein 2 2 3 5
  • PKCI-1-Related HIT Protein 3 4
  • HIT-17kDa 3 4
  • HINT-2 3 4
  • HINT-3 3 4
  • Protein Kinase C Inhibitor-2 3
  • EC 3.-.-.- 4
  • HIT-17 3

External Ids for HINT2 Gene

ORGUL Members for HINT2 Gene

Previous GeneCards Identifiers for HINT2 Gene

  • GC09M036125
  • GC09M035982
  • GC09M035802

Summaries for HINT2 Gene

Entrez Gene Summary for HINT2 Gene

  • Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

GeneCards Summary for HINT2 Gene

HINT2 (Histidine Triad Nucleotide Binding Protein 2) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with HINT2 include Hepatocellular Carcinoma. GO annotations related to this gene include nucleotide binding and hydrolase activity. An important paralog of this gene is HINT1.

UniProtKB/Swiss-Prot for HINT2 Gene

  • Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HINT2 Gene

Genomics for HINT2 Gene

Regulatory Elements for HINT2 Gene

Enhancers for HINT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HINT2 on UCSC Golden Path with GeneCards custom track

Promoters for HINT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HINT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HINT2 Gene

35,812,960 bp from pter
35,815,479 bp from pter
2,520 bases
Minus strand

Genomic View for HINT2 Gene

Genes around HINT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HINT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HINT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HINT2 Gene

Proteins for HINT2 Gene

  • Protein details for HINT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Histidine triad nucleotide-binding protein 2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5TCW3

    Protein attributes for HINT2 Gene

    163 amino acids
    Molecular mass:
    17162 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HINT2 Gene

neXtProt entry for HINT2 Gene

Proteomics data for HINT2 Gene at MOPED

Post-translational modifications for HINT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HINT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HINT2 Gene

Domains & Families for HINT2 Gene

Protein Domains for HINT2 Gene

Suggested Antigen Peptide Sequences for HINT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HIT domain.
  • Belongs to the HINT family.
  • Contains 1 HIT domain.
  • Belongs to the HINT family.
genes like me logo Genes that share domains with HINT2: view

No data available for Gene Families for HINT2 Gene

Function for HINT2 Gene

Molecular function for HINT2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=128 uM for adenosine 5-O-p-nitrophenylphosphoramidate {ECO:0000269 PubMed:16762638};
UniProtKB/Swiss-Prot Function:
Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.

Enzyme Numbers (IUBMB) for HINT2 Gene

Gene Ontology (GO) - Molecular Function for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with HINT2: view
genes like me logo Genes that share phenotypes with HINT2: view

Animal Model Products

miRNA for HINT2 Gene

miRTarBase miRNAs that target HINT2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HINT2 Gene

Localization for HINT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HINT2 Gene


Subcellular locations from

Jensen Localization Image for HINT2 Gene COMPARTMENTS Subcellular localization image for HINT2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with HINT2: view

Pathways & Interactions for HINT2 Gene

SuperPathways for HINT2 Gene

No Data Available

Interacting Proteins for HINT2 Gene

Gene Ontology (GO) - Biological Process for HINT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006694 steroid biosynthetic process IEA --
genes like me logo Genes that share ontologies with HINT2: view

No data available for Pathways by source and SIGNOR curated interactions for HINT2 Gene

Drugs & Compounds for HINT2 Gene

No Compound Related Data Available

Transcripts for HINT2 Gene

Unigene Clusters for HINT2 Gene

Histidine triad nucleotide binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HINT2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - -
SP2: -
SP4: - -
SP6: -

Relevant External Links for HINT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HINT2 Gene

mRNA expression in normal human tissues for HINT2 Gene

Protein differential expression in normal tissues from HIPED for HINT2 Gene

This gene is overexpressed in Liver, secretome (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HINT2 Gene

SOURCE GeneReport for Unigene cluster for HINT2 Gene Hs.70573

mRNA Expression by UniProt/SwissProt for HINT2 Gene

Tissue specificity: High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.
genes like me logo Genes that share expression patterns with HINT2: view

Protein tissue co-expression partners for HINT2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HINT2 Gene

Orthologs for HINT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for HINT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HINT2 35
  • 90.89 (n)
  • 94 (a)
HINT2 36
  • 93 (a)
(Canis familiaris)
Mammalia HINT2 35
  • 89.78 (n)
  • 88.34 (a)
HINT2 36
  • 88 (a)
(Mus musculus)
Mammalia Hint2 35
  • 85.55 (n)
  • 86.71 (a)
Hint2 16
Hint2 36
  • 86 (a)
(Pan troglodytes)
Mammalia HINT2 35
  • 99.8 (n)
  • 100 (a)
HINT2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hint2 35
  • 86.25 (n)
  • 87.41 (a)
(Monodelphis domestica)
Mammalia HINT2 36
  • 85 (a)
(Gallus gallus)
Aves LOC100859112 35
  • 68.14 (n)
  • 72.79 (a)
HINT2 36
  • 65 (a)
(Anolis carolinensis)
Reptilia HINT2 36
  • 72 (a)
(Danio rerio)
Actinopterygii Dr.16548 35
hint2 35
  • 64.86 (n)
  • 68.22 (a)
hint2 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2862 37
  • 60 (a)
CG2862 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea F21C3.3 37
  • 55 (a)
hint-1 36
  • 52 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons HINT 2 35
  • 57.72 (n)
  • 53.66 (a)
(Zea mays)
Liliopsida Zm.2313 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1686 36
  • 50 (a)
Species with no ortholog for HINT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HINT2 Gene

Gene Tree for HINT2 (if available)
Gene Tree for HINT2 (if available)

Paralogs for HINT2 Gene

Paralogs for HINT2 Gene

(2) SIMAP similar genes for HINT2 Gene using alignment to 1 proteins: Pseudogenes for HINT2 Gene

genes like me logo Genes that share paralogs with HINT2: view

Variants for HINT2 Gene

Sequence variations from dbSNP and Humsavar for HINT2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7848310 -- 35,815,673(+) AGGGC(A/G)GTTTC upstream-variant-2KB
rs113272557 -- 35,815,434(+) GTTCC(C/T)ATTGG upstream-variant-2KB, utr-variant-5-prime
rs113329056 -- 35,816,220(+) CCAAG(G/T)TGCTG upstream-variant-2KB
rs113383080 -- 35,814,709(+) GGGCG(A/G)GAATC intron-variant
rs115221066 -- 35,814,491(+) TTCTC(C/T)GACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HINT2 Gene

Variant ID Type Subtype PubMed ID
dgv8168n71 CNV Gain 21882294

Variation tolerance for HINT2 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HINT2 Gene

Disorders for HINT2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HINT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search HINT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HINT2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HINT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HINT2 Gene

Publications for HINT2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Identifying biological pathways that underlie primordial short stature using network analysis. (PMID: 24711643) Hanson D. … Clayton P.E. (J. Mol. Endocrinol. 2014) 3
  3. Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily. (PMID: 23659632) Maize K.M. … Finzel B.C. (FEBS J. 2013) 3
  4. Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. (PMID: 23682076) Lee L.R. … Syed V. (Cancer Prev Res (Phila) 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for HINT2 Gene

Sources for HINT2 Gene