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Aliases for HINFP Gene

Aliases for HINFP Gene

  • Histone H4 Transcription Factor 2 3 5
  • Histone Nuclear Factor P 2 3 4
  • Methyl-CpG-Binding Protein 2-Interacting Zinc Finger Protein 3 4
  • MBD2-Interacting Zinc Finger Protein 3 4
  • MBD2-Interacting Zinc Finger 1 2 3
  • HiNF-P 3 4
  • ZNF743 3 4
  • MIZF 3 4
  • MBD2 (Methyl-CpG-Binding Protein)-Interacting Zinc Finger Protein 3
  • Histone H4 Gene-Specific Protein HiNF-P 3
  • MBD2-Interacting Zinc Finger 2

External Ids for HINFP Gene

Previous HGNC Symbols for HINFP Gene

  • MIZF

Previous GeneCards Identifiers for HINFP Gene

  • GC11P118498
  • GC11P118992
  • GC11P114931

Summaries for HINFP Gene

Entrez Gene Summary for HINFP Gene

  • This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for HINFP Gene

HINFP (Histone H4 Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding. An important paralog of this gene is RREB1.

UniProtKB/Swiss-Prot for HINFP Gene

  • Transcriptional repressor that binds to the consensus sequence 5-CGGACGTT-3 and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Gene Wiki entry for HINFP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HINFP Gene

Genomics for HINFP Gene

Regulatory Elements for HINFP Gene

Promoters for HINFP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HINFP on UCSC Golden Path with GeneCards custom track

Genomic Location for HINFP Gene

Chromosome:
11
Start:
119,121,523 bp from pter
End:
119,136,044 bp from pter
Size:
14,522 bases
Orientation:
Plus strand

Genomic View for HINFP Gene

Genes around HINFP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HINFP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HINFP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HINFP Gene

Proteins for HINFP Gene

  • Protein details for HINFP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQA5-HINFP_HUMAN
    Recommended name:
    Histone H4 transcription factor
    Protein Accession:
    Q9BQA5
    Secondary Accessions:
    • B3KPH6
    • B4DWB4
    • E9PQF4
    • Q96E65
    • Q9Y4M7

    Protein attributes for HINFP Gene

    Size:
    517 amino acids
    Molecular mass:
    59678 Da
    Quaternary structure:
    • Binds MBD2 and a histone deacetylase complex. Interacts with NPAT.

    Alternative splice isoforms for HINFP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HINFP Gene

Proteomics data for HINFP Gene at MOPED

Post-translational modifications for HINFP Gene

  • Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HINFP Gene

No data available for DME Specific Peptides for HINFP Gene

Domains & Families for HINFP Gene

Gene Families for HINFP Gene

Protein Domains for HINFP Gene

Suggested Antigen Peptide Sequences for HINFP Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQA5

UniProtKB/Swiss-Prot:

HINFP_HUMAN :
  • Contains 9 C2H2-type zinc fingers.
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HINFP: view

Function for HINFP Gene

Molecular function for HINFP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that binds to the consensus sequence 5-CGGACGTT-3 and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Gene Ontology (GO) - Molecular Function for HINFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003713 transcription coactivator activity IDA 18850719
GO:0005515 protein binding IPI 11553631
GO:0044212 transcription regulatory region DNA binding IDA 14752047
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HINFP: view

Phenotypes for HINFP Gene

genes like me logo Genes that share phenotypes with HINFP: view

Animal Models for HINFP Gene

MGI Knock Outs for HINFP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HINFP Gene

Localization for HINFP Gene

Subcellular locations from UniProtKB/Swiss-Prot for HINFP Gene

Nucleus. Note=Associated with discrete nuclear foci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HINFP Gene COMPARTMENTS Subcellular localization image for HINFP gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for HINFP Gene

Pathways & Interactions for HINFP Gene

SuperPathways for HINFP Gene

No Data Available

Gene Ontology (GO) - Biological Process for HINFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IMP 14585971
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IMP 15988025
GO:0006355 regulation of transcription, DNA-templated IMP 9540062
GO:0010468 regulation of gene expression IMP 15988025
GO:0010628 positive regulation of gene expression IMP 14585971
genes like me logo Genes that share ontologies with HINFP: view

No data available for Pathways by source and SIGNOR curated interactions for HINFP Gene

Drugs & Compounds for HINFP Gene

No Compound Related Data Available

Transcripts for HINFP Gene

Unigene Clusters for HINFP Gene

Histone H4 transcription factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HINFP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ·
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9:
SP10: - - -
SP11:
SP12: -

ExUns: 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HINFP Gene

GeneLoc Exon Structure for
HINFP
ECgene alternative splicing isoforms for
HINFP

Expression for HINFP Gene

mRNA expression in normal human tissues for HINFP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HINFP Gene



SOURCE GeneReport for Unigene cluster for HINFP Gene Hs.504091

mRNA Expression by UniProt/SwissProt for HINFP Gene

Q9BQA5-HINFP_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.
genes like me logo Genes that share expression patterns with HINFP: view

Protein tissue co-expression partners for HINFP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for HINFP Gene

Orthologs for HINFP Gene

This gene was present in the common ancestor of animals.

Orthologs for HINFP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HINFP 35
  • 87.51 (n)
  • 89.9 (a)
HINFP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HINFP 35
  • 88.7 (n)
  • 91.47 (a)
HINFP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hinfp 35
  • 88.19 (n)
  • 89.17 (a)
Hinfp 16
Hinfp 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HINFP 35
  • 99.87 (n)
  • 100 (a)
HINFP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hinfp 35
  • 87.89 (n)
  • 88.48 (a)
oppossum
(Monodelphis domestica)
Mammalia HINFP 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HINFP 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves HINFP 35
  • 72.17 (n)
  • 70.73 (a)
HINFP 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HINFP 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hinfp 35
  • 70.29 (n)
  • 70.12 (a)
zebrafish
(Danio rerio)
Actinopterygii hinfp 35
  • 61.18 (n)
  • 61.26 (a)
hinfp 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17829 35
  • 48.81 (n)
  • 35.31 (a)
CG17829 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F39B2.1 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2689 36
  • 40 (a)
OneToOne
Species with no ortholog for HINFP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HINFP Gene

ENSEMBL:
Gene Tree for HINFP (if available)
TreeFam:
Gene Tree for HINFP (if available)

Paralogs for HINFP Gene

Paralogs for HINFP Gene

genes like me logo Genes that share paralogs with HINFP: view

Variants for HINFP Gene

Sequence variations from dbSNP and Humsavar for HINFP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs100803 - 119,134,422(-) CAGGG(A/G)CTGGG reference, missense, utr-variant-3-prime
rs17850972 - 119,126,954(+) CGCCT(C/T)CTGGG intron-variant, reference, missense
rs17850974 - 119,130,775(+) TGGAC(A/T)GTTCT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs34118252 - 119,133,135(+) TGACA(A/G)ATGCT reference, missense
rs7234 -- 119,134,775(-) GTTAT(A/G)GTTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HINFP Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294
nsv468879 CNV Loss 19166990
nsv514 CNV Loss 18451855

Variation tolerance for HINFP Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HINFP Gene

HapMap Linkage Disequilibrium report
HINFP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HINFP Gene

Disorders for HINFP Gene

Relevant External Links for HINFP

Genetic Association Database (GAD)
HINFP
Human Genome Epidemiology (HuGE) Navigator
HINFP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HINFP

No disorders were found for HINFP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HINFP Gene

Publications for HINFP Gene

  1. Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. (PMID: 11553631) Sekimata M. … Homma Y. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF. (PMID: 14752047) Sekimata M. … Homma Y. (Nucleic Acids Res. 2004) 3 23
  3. Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation. (PMID: 15541338) Sekimata M. … Homma Y. (Biochem. Biophys. Res. Commun. 2004) 3 23
  4. Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress. (PMID: 25245946) Jeon B.N. … Hur M.W. (Nucleic Acids Res. 2014) 3
  5. The novel function of HINFP as a co-activator in sterol-regulated transcription of PCSK9 in HepG2 cells. (PMID: 22288532) Li H. … Liu J. (Biochem. J. 2012) 3

Products for HINFP Gene

Sources for HINFP Gene

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