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Aliases for HINFP Gene

Aliases for HINFP Gene

  • Histone H4 Transcription Factor 2 3
  • Histone Nuclear Factor P 2 3 4
  • MIZF 3 4 6
  • Methyl-CpG-Binding Protein 2-Interacting Zinc Finger Protein 3 4
  • MBD2-Interacting Zinc Finger Protein 3 4
  • MBD2-Interacting Zinc Finger 1 2 3
  • HiNF-P 3 4
  • ZNF743 3 4
  • MBD2 (Methyl-CpG-Binding Protein)-Interacting Zinc Finger Protein 3
  • Histone H4 Gene-Specific Protein HiNF-P 3
  • MBD2-Interacting Zinc Finger 2

External Ids for HINFP Gene

Previous HGNC Symbols for HINFP Gene

  • MIZF

Previous GeneCards Identifiers for HINFP Gene

  • GC11P118498
  • GC11P118992
  • GC11P114931

Summaries for HINFP Gene

Entrez Gene Summary for HINFP Gene

  • This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for HINFP Gene

HINFP (Histone H4 Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is CTCFL.

UniProtKB/Swiss-Prot for HINFP Gene

  • Transcriptional repressor that binds to the consensus sequence 5-CGGACGTT-3 and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Gene Wiki entry for HINFP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HINFP Gene

Genomics for HINFP Gene

Regulatory Elements for HINFP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HINFP Gene

Start:
119,121,523 bp from pter
End:
119,136,044 bp from pter
Size:
14,522 bases
Orientation:
Plus strand

Genomic View for HINFP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HINFP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HINFP Gene

Proteins for HINFP Gene

  • Protein details for HINFP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQA5-HINFP_HUMAN
    Recommended name:
    Histone H4 transcription factor
    Protein Accession:
    Q9BQA5
    Secondary Accessions:
    • B3KPH6
    • B4DWB4
    • E9PQF4
    • Q96E65
    • Q9Y4M7

    Protein attributes for HINFP Gene

    Size:
    517 amino acids
    Molecular mass:
    59678 Da
    Quaternary structure:
    • Binds MBD2 and a histone deacetylase complex. Interacts with NPAT.

    Alternative splice isoforms for HINFP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HINFP Gene

Proteomics data for HINFP Gene at MOPED

Post-translational modifications for HINFP Gene

  • Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HINFP Gene

Antibody Products

No data available for DME Specific Peptides for HINFP Gene

Domains for HINFP Gene

Gene Families for HINFP Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for HINFP Gene

Suggested Antigen Peptide Sequences for HINFP Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQA5

UniProtKB/Swiss-Prot:

HINFP_HUMAN :
  • Q9BQA5
Similarity:
  • Contains 9 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HINFP: view

Function for HINFP Gene

Molecular function for HINFP Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor that binds to the consensus sequence 5-CGGACGTT-3 and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Gene Ontology (GO) - Molecular Function for HINFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 18850719
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IMP 9540062
GO:0003713 transcription coactivator activity IDA 18850719
GO:0005515 protein binding IPI 11553631
genes like me logo Genes that share ontologies with HINFP: view

Phenotypes for HINFP Gene

MGI mutant phenotypes for HINFP:
inferred from 1 alleles
GenomeRNAi human phenotypes for HINFP:
genes like me logo Genes that share phenotypes with HINFP: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HINFP Gene

Localization for HINFP Gene

Subcellular locations from UniProtKB/Swiss-Prot for HINFP Gene

Nucleus. Note=Associated with discrete nuclear foci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HINFP Gene COMPARTMENTS Subcellular localization image for HINFP gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HINFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14585971
GO:0005654 nucleoplasm IDA 11553631
GO:0005730 NOT nucleolus IDA 11553631
GO:0015030 Cajal body IDA 15988025
genes like me logo Genes that share ontologies with HINFP: view

Pathways for HINFP Gene

SuperPathways for HINFP Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for HINFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 17974976
GO:0000082 G1/S transition of mitotic cell cycle IMP 14585971
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IMP 15988025
GO:0001701 in utero embryonic development ISS --
GO:0006281 DNA repair IMP 17974976
genes like me logo Genes that share ontologies with HINFP: view

No data available for Pathways by source for HINFP Gene

Transcripts for HINFP Gene

Unigene Clusters for HINFP Gene

Histone H4 transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HINFP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HINFP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ·
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9:
SP10: - - -
SP11:
SP12: -

ExUns: 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HINFP Gene

GeneLoc Exon Structure for
HINFP
ECgene alternative splicing isoforms for
HINFP

Expression for HINFP Gene

mRNA expression in normal human tissues for HINFP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HINFP Gene

SOURCE GeneReport for Unigene cluster for HINFP Gene Hs.504091

mRNA Expression by UniProt/SwissProt for HINFP Gene

Q9BQA5-HINFP_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.
genes like me logo Genes that share expressions with HINFP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HINFP Gene

Orthologs for HINFP Gene

This gene was present in the common ancestor of animals.

Orthologs for HINFP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HINFP 35
  • 99.87 (n)
  • 100 (a)
HINFP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HINFP 35
  • 87.51 (n)
  • 89.9 (a)
HINFP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HINFP 35
  • 88.7 (n)
  • 91.47 (a)
HINFP 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hinfp 35
  • 88.19 (n)
  • 89.17 (a)
Hinfp 16
Hinfp 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HINFP 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HINFP 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hinfp 35
  • 87.89 (n)
  • 88.48 (a)
chicken
(Gallus gallus)
Aves HINFP 35
  • 72.17 (n)
  • 70.73 (a)
HINFP 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HINFP 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hinfp 35
  • 70.29 (n)
  • 70.12 (a)
zebrafish
(Danio rerio)
Actinopterygii hinfp 35
  • 61.18 (n)
  • 61.26 (a)
hinfp 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17829 35
  • 48.81 (n)
  • 35.31 (a)
CG17829 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F39B2.1 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2689 36
  • 40 (a)
OneToOne
Species with no ortholog for HINFP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HINFP Gene

ENSEMBL:
Gene Tree for HINFP (if available)
TreeFam:
Gene Tree for HINFP (if available)

Paralogs for HINFP Gene

Paralogs for HINFP Gene

genes like me logo Genes that share paralogs with HINFP: view

Variants for HINFP Gene

Sequence variations from dbSNP and Humsavar for HINFP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7234 -- 119,134,775(-) GTTAT(A/G)GTTAA utr-variant-3-prime
rs100803 - 119,134,422(-) CAGGG(A/G)CTGGG utr-variant-3-prime, reference, missense
rs495255 -- 119,128,196(+) AGGTA(A/T)GCCTT intron-variant
rs512703 -- 119,134,378(+) GAGAT(C/T)GTCTA reference, synonymous-codon
rs521012 -- 119,128,761(+) tggtg(C/G)gatct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HINFP Gene

Variant ID Type Subtype PubMed ID
nsv898416 CNV Loss 21882294
nsv468879 CNV Loss 19166990
nsv514 CNV Loss 18451855

Relevant External Links for HINFP Gene

HapMap Linkage Disequilibrium report
HINFP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HINFP Gene

Disorders for HINFP Gene

Relevant External Links for HINFP

Genetic Association Database (GAD)
HINFP
Human Genome Epidemiology (HuGE) Navigator
HINFP
genes like me logo Genes that share disorders with HINFP: view

No data available for UniProtKB/Swiss-Prot for HINFP Gene

Publications for HINFP Gene

  1. Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. (PMID: 11553631) Sekimata M. … Homma Y. (J. Biol. Chem. 2001) 2 3 4 23
  2. Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF. (PMID: 14752047) Sekimata M. … Homma Y. (Nucleic Acids Res. 2004) 3 4 23
  3. Regulation of Rb gene expression by an MBD2-interacting zinc finger protein MIZF during myogenic differentiation. (PMID: 15541338) Sekimata M. … Homma Y. (Biochem. Biophys. Res. Commun. 2004) 3 23
  4. Identification of HiNF-P, a key activator of cell cycle-controlled histone H4 genes at the onset of S phase. (PMID: 14585971) Mitra P. … Stein G.S. (Mol. Cell. Biol. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for HINFP Gene

Sources for HINFP Gene

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