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HINFP Gene

protein-coding   GIFtS: 51
GCID: GC11P118992

Histone H4 Transcription Factor

(Previous names: MBD2-interacting zinc finger 1, MBD2-interacting zinc finger)
(Previous symbol: MIZF)
  Search for HINFP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Histone H4 Transcription Factor1 2     ZNF7432 3
MIZF1 2 3 5     MBD2-Interacting Zinc Finger Protein2 3
Histone Nuclear Factor P1 2 3     MBD2-Interacting Zinc Finger1
MBD2-Interacting Zinc Finger 11 2     Histone H4 Gene-Specific Protein HiNF-P2
Methyl-CpG-Binding Protein 2-Interacting Zinc Finger Protein2 3     MBD2 (Methyl-CpG-Binding Protein)-Interacting Zinc Finger Protein2
HiNF-P2 3     

External Ids:    HGNC: 178501   Entrez Gene: 259882   Ensembl: ENSG000001722737   OMIM: 6070995   UniProtKB: Q9BQA53   

Export aliases for HINFP gene to outside databases

Previous GC identifers: GC11P118498 GC11P114931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HINFP Gene:
This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of
the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression.
Alternatively spliced transcript variants have been found for this gene.(provided by RefSeq, Aug 2011)

GeneCards Summary for HINFP Gene:
HINFP (histone H4 transcription factor) is a protein-coding gene. GO annotations related to this gene include enzyme binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CTCF.

UniProtKB/Swiss-Prot: HINFP_HUMAN, Q9BQA5
Function: Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter.
Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction
with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating
with its own promoter

Gene Wiki entry for HINFP (MIZF) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HINFP gene promoter:
         c-Fos   AP-1   ATF-2   p300   c-Jun   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HINFP promoter sequence
   Search Chromatin IP Primers for HINFP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HINFP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

HINFP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HINFP gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118992:  view genomic region     (about GC identifiers)

Start:
118,992,288 bp from pter      End:
119,006,752 bp from pter
Size:
14,465 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HINFP_HUMAN, Q9BQA5 (See protein sequence)
Recommended Name: Histone H4 transcription factor  
Size: 517 amino acids; 59678 Da
Subunit: Binds MBD2 and a histone deacetylase complex. Interacts with NPAT
Secondary accessions: B3KPH6 B4DWB4 E9PQF4 Q96E65 Q9Y4M7
Alternative splicing: 2 isoforms:  Q9BQA5-1   Q9BQA5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HINFP: NX_Q9BQA5

Explore proteomics data for HINFP at MOPED

Post-translational modifications: 

  • Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HINFP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230188.1  NP_056332.2  NP_945322.1  

    ENSEMBL proteins: 
     ENSP00000318085   ENSP00000431468   ENSP00000436815   ENSP00000433836   ENSP00000434574  

    HINFP Human Recombinant Protein Products:

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    Novus Biologicals HINFP Proteins
    Novus Biologicals HINFP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HINFP 

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    LSBio Antibodies in human, mouse, rat for HINFP

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    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for HINFP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BQA5

    ProtoNet protein and cluster: Q9BQA5

    UniProtKB/Swiss-Prot: HINFP_HUMAN, Q9BQA5
    Similarity: Contains 9 C2H2-type zinc fingers


    Find genes that share domains with HINFP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HINFP_HUMAN, Q9BQA5
    Function: Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter.
    Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction
    with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating
    with its own promoter

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA18850719
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IMP9540062
    GO:0003713transcription coactivator activity IDA18850719
    GO:0005515protein binding IPI11553631
         
    Find genes that share ontologies with HINFP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HINFP:
     Increased S DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hinfp):
     embryogenesis  mortality/aging 

    Find genes that share phenotypes with HINFP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HINFP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HINFP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HINFP
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    Block miRNA regulation of human, mouse, rat HINFP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HINFP (see all 9):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-3679-5p hsa-miR-1185 hsa-miR-544b hsa-miR-125b hsa-miR-670 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidHINFP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HINFP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): HINFP (NM_198971)
    Sino Biological Human cDNA Clone for HINFP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HINFP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HINFP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINFP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HINFP_HUMAN, Q9BQA5: Nucleus. Note=Associated with discrete nuclear foci
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA14585971
    GO:0005654nucleoplasm IDA11553631
    GO:0005730NOT nucleolus IDA11553631
    GO:0015030Cajal body IDA15988025

    Find genes that share ontologies with HINFP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including HINFP: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HINFP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for HINFP (Q9BQA52, 3 ENSP000003180854) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206495Q9HCM93I2D: score=1 
    ENSG00000224994Q9HCM93I2D: score=1 
    ENSG00000226437Q9HCM93I2D: score=1 
    ENSG00000229929Q9HCM93I2D: score=1 
    ENSG00000230308Q9HCM93I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint IMP17974976
    GO:0000082G1/S transition of mitotic cell cycle IMP14585971
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle IMP15988025
    GO:0001701in utero embryonic development ISS--
    GO:0006281DNA repair IMP17974976

    Find genes that share ontologies with HINFP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HINFP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HINFP gene (3 alternative transcripts): 
    NM_001243259.1  NM_015517.4  NM_198971.2  

    Unigene Cluster for HINFP:

    Histone H4 transcription factor
    Hs.504091  [show with all ESTs]
    Unigene Representative Sequence: NM_015517
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000350777(uc001pvp.3 uc021qrj.1 uc001pvq.3) ENST00000527206
    ENST00000529354(uc010rzb.2) ENST00000529988 ENST00000531360 ENST00000527354
    ENST00000527410 ENST00000530678 ENST00000532312 ENST00000531022 ENST00000529610
    ENST00000527755(uc001pvr.3) ENST00000529808 ENST00000532860
    miRNA
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    Block miRNA regulation of human, mouse, rat HINFP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HINFP (see all 9):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-3679-5p hsa-miR-1185 hsa-miR-544b hsa-miR-125b hsa-miR-670 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidHINFP 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HINFP
    Predesigned siRNA for gene silencing in human, mouse, rat HINFP
    Clone
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    OriGene clones in human, mouse for HINFP (see all 11)
    OriGene ORF clones in mouse, rat for HINFP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HINFP (NM_198971)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HINFP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HINFP
    Primer
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    OriGene qPCR primer pairs and template standards for HINFP
    OriGene qSTAR qPCR primer pairs in human, mouse for HINFP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HINFP
      QuantiTect SYBR Green Assays in human, mouse, rat HINFP
      QuantiFast Probe-based Assays in human, mouse, rat HINFP

    Additional mRNA sequence: 

    AK056362.1 AK300288.1 AK301452.1 AL080201.1 BC001073.2 BC001945.1 BC012856.1 BC017234.2 

    13 DOTS entries:

    DT.100755097  DT.213882  DT.100755093  DT.100733166  DT.100032775  DT.95374742  DT.92429083  DT.100755096 
    DT.120687000  DT.120686997  DT.120687005  DT.97812429  DT.40220453 

    Selected AceView cDNA sequences (see all 161):

    CA418874 AU280618 AL561450 AA806747 BI818767 BQ650146 T33220 AW939605 
    BX955478 CR599076 AW939532 AK056362 BQ432273 BU738910 NM_015517 BQ439105 
    BU501477 BF726036 NM_198971 BM713861 BM461802 BU742778 AW160791 BM982227 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HINFP (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ·
    SP1:                                      -     -                 -     -                                   -                                   -               
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                            -               
    SP4:                                      -                       -     -                                   -                                                   
    SP5:                                                                                                        -                                                   

    ExUns: 14c
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for HINFP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HINFP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTATCCTCA
    HINFP Expression
    About this image

    HINFP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HINFP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504091

    UniProtKB/Swiss-Prot: HINFP_HUMAN, Q9BQA5
    Tissue specificity: Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small
    intestine, placenta and liver

        Pathway & Disease-focused RT2 Profiler PCR Array including HINFP: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HINFP
    OriGene qSTAR qPCR primer pairs in human, mouse for HINFP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HINFP
    QuantiTect SYBR Green Assays in human, mouse, rat HINFP
    QuantiFast Probe-based Assays in human, mouse, rat HINFP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HINFP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HINFP gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hinfp1 , 5 histone H4 transcription factor1, 5 88.19(n)1
    89.17(a)1
      9 (24.84 cM)5
    1024231  NM_172162.31  NP_751894.21 
     442956735 
    chicken
    (Gallus gallus)
    Aves HINFP1 histone H4 transcription factor 72.17(n)
    70.73(a)
      419756  XM_417894.3  XP_417894.3 
    lizard
    (Anolis carolinensis)
    Reptilia HINFP6
    histone H4 transcription factor
    65(a)
    1 ↔ 1
    GL343722.1(113643-120426)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU913237.12   -- 76.61(n)    BU913237.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC057479.12   -- 76.16(n)    BC057479.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG178291 CG17829 48.81(n)
    35.31(a)
      47718  NM_143797.2  NP_652054.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F39B2.16
    Protein F39B2.1 (F39B2.1) mRNA, complete cds
    23(a)
    1 ↔ 1
    I(14791038-14794390) WBGene00009553


    ENSEMBL Gene Tree for HINFP (if available)
    TreeFam Gene Tree for HINFP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HINFP gene
    CTCF2  CTCFL2  ZFP642  
    Selected SIMAP similar genes for HINFP using alignment to 4 protein entries:     HINFP_HUMAN (see all proteins) (see all similar genes):
    TAF2    EEF1E1    PFKFB3    C12orf76    IRF2    TUBA1C
    ZNF114    C1orf143    ARL6IP5    NOSTRIN    VPS33A    TNNT1
    ATF1    C21orf37    CDK10    NELFA    RRM2B    DYNC2LI1

    Find genes that share paralogs with HINFP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HINFP (see all 363)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs798737911,2
    C,F--118990253(+) CCTCTT/CAGGTT 3 -- us2k18Minor allele frequency- C:0.28NA WA CSA 18
    rs1860019891,2
    C--118990265(+) AAGCGA/CTTTTC 3 -- us2k10--------
    rs594176801,2
    C--118990503(+) TAAAA-/ACCAAA 3 -- us2k10--------
    rs1907646351,2
    C--118990581(+) AACATC/TTAATG 3 -- us2k10--------
    rs1833420491,2
    --118990821(+) CTGGTA/GTGCAG 3 -- us2k10--------
    rs1880849471,2
    --118990894(+) CCTCCC/TGAGTA 3 -- us2k10--------
    rs1919815291,2
    --118990997(+) GCTCCC/TGACCT 3 -- us2k10--------
    rs1508847031,2
    C--118991017(+) CACTCA/GCCTCG 3 -- us2k10--------
    rs6758661,2
    C,F,A,H--118991019(+) ctcgcA/Ctcggc 3 -- us2k18Minor allele frequency- C:0.29NA WA CSA 17
    rs1181295861,2
    F--118991186(+) TCAGGA/GAGACT 3 -- us2k11Minor allele frequency- G:0.02EA 120

    HapMap Linkage Disequilibrium report for HINFP (118992288 - 119006752 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HINFP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468879CNV Loss19166990
    nsv898416CNV Loss21882294
    nsv514CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for HINFP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607099    OMIM disorders: --


    Find genes that share disorders with HINFP           About GenesLikeMe

    Genetic Association Database (GAD): HINFP
    Human Genome Epidemiology (HuGE) Navigator: HINFP (3 documents)

    Export disorders for HINFP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HINFP gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with HINFP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. (PubMed id 11553631)1, 2, 3, 9 Sekimata M.... Homma Y. (J. Biol. Chem. 2001)
    2. Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF. (PubMed id 14752047)1, 2, 9 Sekimata M. and Homma Y. (Nucleic Acids Res. 2004)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. (PubMed id 18850719)1, 2 Medina R.... Stein G.S. (Biochemistry 2008)
    5. The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. (PubMed id 17974976)1, 2 Medina R.... Stein G.S. (Cancer Res. 2007)
    6. HiNF-P is a bifunctional regulator of cell cycle controlled histone H4 gene transcription. (PubMed id 17163457)1, 2 Mitra P....van Wijnen A.J. (J. Cell. Biochem. 2007)
    7. The histone gene transcription factor HiNF-P stabilizes its cell cycle regulatory co-activator p220NPAT. (PubMed id 17176114)1, 2 Medina R.... Stein J.L. (Biochemistry 2006)
    8. HiNF-P directly links the cyclin E/CDK2/p220NPAT pathway to histone H4 gene regulation at the G1/S phase cell cycle transition. (PubMed id 15988025)1, 2 Miele A....Stein G.S. (Mol. Cell. Biol. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25988 HGNC: 17850 AceView: MIZF Ensembl:ENSG00000172273 euGenes: HUgn25988
    ECgene: HINFP H-InvDB: HINFP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HINFP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HINFP gene:
    Search GeneIP for patents involving HINFP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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