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Aliases for HINFP Gene

Aliases for HINFP Gene

  • Histone H4 Transcription Factor 2 3 5
  • Histone Nuclear Factor P 2 3 4
  • Methyl-CpG-Binding Protein 2-Interacting Zinc Finger Protein 3 4
  • MBD2-Interacting Zinc Finger Protein 3 4
  • MBD2-Interacting Zinc Finger 1 2 3
  • HiNF-P 3 4
  • ZNF743 3 4
  • MIZF 3 4
  • MBD2 (Methyl-CpG-Binding Protein)-Interacting Zinc Finger Protein 3
  • Histone H4 Gene-Specific Protein HiNF-P 3
  • MBD2-Interacting Zinc Finger 2

External Ids for HINFP Gene

Previous HGNC Symbols for HINFP Gene

  • MIZF

Previous GeneCards Identifiers for HINFP Gene

  • GC11P118498
  • GC11P118992
  • GC11P114931

Summaries for HINFP Gene

Entrez Gene Summary for HINFP Gene

  • This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for HINFP Gene

HINFP (Histone H4 Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding.

UniProtKB/Swiss-Prot for HINFP Gene

  • Transcriptional repressor that binds to the consensus sequence 5-CGGACGTT-3 and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Gene Wiki entry for HINFP Gene

Additional gene information for HINFP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HINFP Gene

Genomics for HINFP Gene

Regulatory Elements for HINFP Gene

Enhancers for HINFP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H119090 1.6 Ensembl ENCODE dbSUPER 77.2 -27.9 -27852 5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 HINFP KMT2A VPS11 RPL5P30 CCDC84 UBE4A BCL9L ARCN1 IFT46 RNF26
GH11H118433 1.9 VISTA Ensembl ENCODE dbSUPER 30.9 -683.4 -683435 8 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 VPS11 HINFP TMEM25 KMT2A CCDC84 IFT46 ARCN1 THY1 LOC101929089 ATP5L
GH11H119120 1.1 ENCODE 44.5 +0.0 15 2 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS HINFP RNF26 ARCN1 UBE4A ENSG00000254909 BCL9L PIR55037
GH11H118603 2 FANTOM5 Ensembl ENCODE dbSUPER 22 -512.9 -512896 9 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF207 ZNF143 FOS IFT46 TREHP1 KMT2A VPS11 LOC105369519 HINFP CCDC84 TREH SETP16 ENSG00000254892
GH11H119114 0.9 Ensembl ENCODE 43.4 -5.5 -5493 2 BCOR SMARCA5 CTCF PKNOX1 L3MBTL2 NRF1 ZMYM3 GABPA HDAC2 KDM1A HINFP C2CD2L NLRX1 HMBS DPAGT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HINFP on UCSC Golden Path with GeneCards custom track

Promoters for HINFP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045729 177 1401 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS

Genomic Location for HINFP Gene

Chromosome:
11
Start:
119,121,523 bp from pter
End:
119,136,044 bp from pter
Size:
14,522 bases
Orientation:
Plus strand

Genomic View for HINFP Gene

Genes around HINFP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HINFP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HINFP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HINFP Gene

Proteins for HINFP Gene

  • Protein details for HINFP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQA5-HINFP_HUMAN
    Recommended name:
    Histone H4 transcription factor
    Protein Accession:
    Q9BQA5
    Secondary Accessions:
    • B3KPH6
    • B4DWB4
    • E9PQF4
    • Q96E65
    • Q9Y4M7

    Protein attributes for HINFP Gene

    Size:
    517 amino acids
    Molecular mass:
    59678 Da
    Quaternary structure:
    • Binds MBD2 and a histone deacetylase complex. Interacts with NPAT.

    Alternative splice isoforms for HINFP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HINFP Gene

Post-translational modifications for HINFP Gene

  • Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HINFP Gene

Domains & Families for HINFP Gene

Gene Families for HINFP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HINFP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HINFP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HINFP: view

No data available for UniProtKB/Swiss-Prot for HINFP Gene

Function for HINFP Gene

Molecular function for HINFP Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that binds to the consensus sequence 5-CGGACGTT-3 and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.

Phenotypes From GWAS Catalog for HINFP Gene

Gene Ontology (GO) - Molecular Function for HINFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IDA 9540062
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with HINFP: view
genes like me logo Genes that share phenotypes with HINFP: view

Animal Models for HINFP Gene

MGI Knock Outs for HINFP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HINFP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HINFP Gene

Localization for HINFP Gene

Subcellular locations from UniProtKB/Swiss-Prot for HINFP Gene

Nucleus. Note=Associated with discrete nuclear foci.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HINFP gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HINFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 14585971
GO:0005654 nucleoplasm IDA 11553631
GO:0005730 NOT nucleolus IDA 11553631
GO:0005829 cytosol IDA --
GO:0015030 Cajal body IDA 15988025
genes like me logo Genes that share ontologies with HINFP: view

Pathways & Interactions for HINFP Gene

SuperPathways for HINFP Gene

No Data Available

Gene Ontology (GO) - Biological Process for HINFP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 17974976
GO:0000082 G1/S transition of mitotic cell cycle IMP 14585971
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IMP 15988025
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001701 in utero embryonic development ISS --
genes like me logo Genes that share ontologies with HINFP: view

No data available for Pathways by source and SIGNOR curated interactions for HINFP Gene

Drugs & Compounds for HINFP Gene

No Compound Related Data Available

Transcripts for HINFP Gene

Unigene Clusters for HINFP Gene

Histone H4 transcription factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HINFP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HINFP Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ·
SP1: - - - - - -
SP2: -
SP3: -
SP4: - - - -
SP5: -
SP6: - - - - - - - -
SP7: - - - - - -
SP8: - - - -
SP9:
SP10: - - -
SP11:
SP12: -

ExUns: 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HINFP Gene

GeneLoc Exon Structure for
HINFP
ECgene alternative splicing isoforms for
HINFP

Expression for HINFP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HINFP Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HINFP Gene



Protein tissue co-expression partners for HINFP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HINFP Gene:

HINFP

SOURCE GeneReport for Unigene cluster for HINFP Gene:

Hs.504091

mRNA Expression by UniProt/SwissProt for HINFP Gene:

Q9BQA5-HINFP_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver.

Evidence on tissue expression from TISSUES for HINFP Gene

  • Lung(4.3)
  • Eye(4.1)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with HINFP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HINFP Gene

Orthologs for HINFP Gene

This gene was present in the common ancestor of animals.

Orthologs for HINFP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HINFP 33 34
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia HINFP 33 34
  • 88.7 (n)
mouse
(Mus musculus)
Mammalia Hinfp 33 16 34
  • 88.19 (n)
rat
(Rattus norvegicus)
Mammalia Hinfp 33
  • 87.89 (n)
cow
(Bos Taurus)
Mammalia HINFP 33 34
  • 87.51 (n)
oppossum
(Monodelphis domestica)
Mammalia HINFP 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HINFP 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves HINFP 33 34
  • 72.17 (n)
lizard
(Anolis carolinensis)
Reptilia HINFP 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hinfp 33
  • 70.29 (n)
zebrafish
(Danio rerio)
Actinopterygii hinfp 33 34
  • 61.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17829 33 34
  • 48.81 (n)
worm
(Caenorhabditis elegans)
Secernentea F39B2.1 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2689 34
  • 40 (a)
OneToOne
Species where no ortholog for HINFP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HINFP Gene

ENSEMBL:
Gene Tree for HINFP (if available)
TreeFam:
Gene Tree for HINFP (if available)

Paralogs for HINFP Gene

No data available for Paralogs for HINFP Gene

Variants for HINFP Gene

Sequence variations from dbSNP and Humsavar for HINFP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000141451 -- 119,122,848(+) CCTGT(C/T)GCGGT intron-variant, upstream-variant-2KB
rs1000217127 -- 119,135,469(+) AATCA(A/G)GTGGT downstream-variant-500B
rs1000320731 -- 119,131,293(+) TGTGT(G/T)GCCCA intron-variant
rs1000492431 -- 119,123,076(+) TGAGC(C/G)CAGAT intron-variant, upstream-variant-2KB
rs1000726618 -- 119,123,050(+) TTGAA(C/G)CTGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HINFP Gene

Variant ID Type Subtype PubMed ID
nsv468879 CNV loss 19166990
nsv514 CNV deletion 18451855
nsv556466 CNV loss 21841781

Variation tolerance for HINFP Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.83; 79.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HINFP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HINFP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HINFP Gene

Disorders for HINFP Gene

Relevant External Links for HINFP

Genetic Association Database (GAD)
HINFP
Human Genome Epidemiology (HuGE) Navigator
HINFP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HINFP

No disorders were found for HINFP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HINFP Gene

Publications for HINFP Gene

  1. Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. (PMID: 11553631) Sekimata M … Homma Y (The Journal of biological chemistry 2001) 2 3 4 22 60
  2. Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF. (PMID: 14752047) Sekimata M … Homma Y (Nucleic acids research 2004) 3 4 22 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. (PMID: 18850719) Medina R … Stein GS (Biochemistry 2008) 3 4 60
  5. The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. (PMID: 17974976) Medina R … Stein GS (Cancer research 2007) 3 4 60

Products for HINFP Gene

Sources for HINFP Gene

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