Aliases for HINFP Gene
Aliases for HINFP Gene
External Ids for HINFP Gene
- HGNC: 17850
- Entrez Gene: 25988
- Ensembl: ENSG00000172273
- OMIM: 607099
- UniProtKB: Q9BQA5
Previous HGNC Symbols for HINFP Gene
- MIZF
Previous GeneCards Identifiers for HINFP Gene
- GC11P118498
- GC11P118992
- GC11P114931
Summaries for HINFP Gene
-
This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]
GeneCards Summary for HINFP Gene
HINFP (Histone H4 Transcription Factor) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and enzyme binding.
UniProtKB/Swiss-Prot for HINFP Gene
-
Transcriptional repressor that binds to the consensus sequence 5-CGGACGTT-3 and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HINFP Gene
Genomics for HINFP Gene
Regulatory Elements for HINFP Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH11G119090 | 1.7 | Ensembl ENCODE dbSUPER | 47 | -27.9 | -27852 | 5.9 | CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 | HINFP ARCN1 RNF26 ENSG00000254909 C2CD2L BCL9L RPL23AP64 UBE4A RPS25 IFT46 |
| GH11G119120 | 1.1 | ENCODE | 44.5 | +0.0 | 15 | 2.4 | HDGF PKNOX1 MLX CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 YY1 | HINFP UBE4A ARCN1 RNF26 BCL9L PIR55037 |
| GH11G119125 | 1 | ENCODE | 44.1 | +4.7 | 4673 | 2.0 | HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF207 ZNF263 | HINFP HMBS VPS11 ABCG4 NLRX1 PDZD3 C2CD2L H2AFX PIR55037 |
| GH11G119114 | 0.9 | Ensembl ENCODE | 43.4 | -5.5 | -5493 | 2.8 | BCOR SMARCA5 CTCF PKNOX1 ESRRA L3MBTL2 NRF1 ZMYM3 GABPA HDAC2 | HINFP C2CD2L NLRX1 HMBS DPAGT1 |
| GH11G119100 | 1.1 | ENCODE | 35.4 | -19.4 | -19356 | 3.9 | HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 | HINFP NLRX1 ABCG4 HMBS C2CD2L H2AFX |
- Transcription factor binding sites by QIAGEN in the HINFP gene promoter:
Regulatory Element Products
Genomic Location for HINFP Gene
- Chromosome:
- 11
- Start:
- 119,121,523 bp from pter
- End:
- 119,136,044 bp from pter
- Size:
- 14,522 bases
- Orientation:
- Plus strand
Genomic View for HINFP Gene
- Cytogenetic band:
-
- 11q23.3 by Ensembl
- 11q23.3 by Entrez Gene
- 11q23.3 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HINFP Gene
Proteins for HINFP Gene
-
Protein details for HINFP Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BQA5-HINFP_HUMAN
- Recommended name:
- Histone H4 transcription factor
- Protein Accession:
- Q9BQA5
- B3KPH6
- B4DWB4
- E9PQF4
- Q96E65
- Q9Y4M7
Protein attributes for HINFP Gene
- Size:
- 517 amino acids
- Molecular mass:
- 59678 Da
- Quaternary structure:
-
- Binds MBD2 and a histone deacetylase complex. Interacts with NPAT.
Protein Expression for HINFP Gene
Post-translational modifications for HINFP Gene
- Ubiquitinated. Ubiquitination may lead to proteasome-mediated degradation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for HINFP Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HINFP
- Invitrogen Antibodies for HINFP
- antibodies-online Antibodies for HINFP: See all 39
- GeneTex HINFP antibody for HINFP
-
Santa Cruz Biotechnology (SCBT) Antibodies for HINFP
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HINFP
- Origene Custom Protein Services for HINFP
- antibodies-online Proteins for HINFP: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HINFP
Assay Products
- antibodies-online Kits for HINFP: See all 3
No data available for DME Specific Peptides for HINFP Gene
Domains & Families for HINFP Gene
Gene Families for HINFP Gene
Protein Domains for HINFP Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HINFP Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HINFP Gene
Function for HINFP Gene
Molecular function for HINFP Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor that binds to the consensus sequence 5-CGGACGTT-3 and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | -- |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | IEA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA,IDA | 9540062 |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for HINFP Gene
- MGI mutant phenotypes for HINFP:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HINFP:
Animal Models for HINFP Gene
- MGI Knock Outs for HINFP:
-
- Hinfp tm1Gss
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HINFP gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HINFP gene
- Search ViGene Biosciences for HINFP
CRISPR Products
-
OriGene CRISPR knockouts for HINFP
-
Santa Cruz Biotechnology (SCBT) CRISPR for HINFP
- GenScript: Design CRISPR guide RNA sequences for HINFP
miRNA for HINFP Gene
- miRTarBase miRNAs that target HINFP
-
- hsa-mir-1303 (MIRT516915)
- hsa-mir-6083 (MIRT516916)
- hsa-mir-4715-3p (MIRT516917)
- hsa-mir-411-5p (MIRT516918)
- hsa-mir-1227-3p (MIRT516919)
- hsa-mir-6832-5p (MIRT516920)
- hsa-mir-29a-5p (MIRT516921)
- hsa-mir-6872-3p (MIRT516922)
- hsa-mir-483-5p (MIRT516923)
- hsa-mir-3679-3p (MIRT610893)
- hsa-mir-2355-5p (MIRT610894)
- hsa-mir-3613-3p (MIRT610895)
- hsa-mir-501-5p (MIRT610896)
- hsa-mir-548p (MIRT610897)
- hsa-mir-7641 (MIRT637375)
- hsa-mir-4284 (MIRT637376)
- hsa-mir-6778-3p (MIRT637377)
- hsa-mir-4695-3p (MIRT637378)
- hsa-mir-4772-3p (MIRT637379)
- hsa-mir-4638-5p (MIRT637380)
- hsa-mir-1307-3p (MIRT637381)
- hsa-mir-6741-3p (MIRT637382)
- hsa-mir-1304-3p (MIRT637383)
- hsa-mir-6890-3p (MIRT637384)
- hsa-mir-4279 (MIRT677004)
- hsa-mir-365b-5p (MIRT677005)
- hsa-mir-365a-5p (MIRT677006)
- hsa-mir-8052 (MIRT677007)
- hsa-mir-3199 (MIRT677008)
- hsa-mir-1976 (MIRT677009)
- hsa-mir-3653-5p (MIRT677010)
- hsa-mir-6747-3p (MIRT677011)
- hsa-mir-6727-3p (MIRT677012)
- hsa-mir-4722-3p (MIRT677013)
- hsa-mir-4740-3p (MIRT677014)
- hsa-mir-576-3p (MIRT677015)
- hsa-mir-5683 (MIRT677016)
- hsa-mir-5571-5p (MIRT677017)
- hsa-mir-3157-5p (MIRT723022)
- hsa-mir-20a-3p (MIRT723023)
- hsa-mir-1273g-3p (MIRT723024)
- hsa-mir-6807-3p (MIRT723025)
- hsa-mir-217 (MIRT723026)
miRNA Products
- Search ViGene Biosciences for HINFP
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HINFP
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-
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Clone Products
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for HINFP gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HINFP gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HINFP Gene
Localization for HINFP Gene
Subcellular locations from UniProtKB/Swiss-Prot for HINFP Gene
- Nucleus. Note=Associated with discrete nuclear foci.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 14585971 |
| GO:0005654 | nucleoplasm | IDA | 11553631 |
| GO:0005730 | NOT nucleolus | IDA | 11553631 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0015030 | Cajal body | IDA | 15988025 |
Pathways & Interactions for HINFP Gene
Interacting Proteins for HINFP Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IMP | 17974976 |
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | 14585971 |
| GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | IMP | 15988025 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0001701 | in utero embryonic development | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for HINFP Gene
Transcripts for HINFP Gene
mRNA/cDNA for HINFP Gene
- (17) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (161) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HINFP Gene
CRISPR Products
-
OriGene CRISPR knockouts for HINFP
-
Santa Cruz Biotechnology (SCBT) CRISPR for HINFP
- GenScript: Design CRISPR guide RNA sequences for HINFP
miRNA Products
- Search ViGene Biosciences for HINFP
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HINFP
- Browse OriGene Inhibitory RNA Products For HINFP
-
ViGene Biosciences ready-to-package AAV shRNAs for HINFP gene
Clone Products
- Sino Biological Human cDNA Clone for HINFP
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 14c |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: | |
| SP12: |
Expression for HINFP Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HINFP Gene
NURSA nuclear receptor signaling pathways regulating expression of HINFP Gene:
HINFPSOURCE GeneReport for Unigene cluster for HINFP Gene:
Hs.504091mRNA Expression by UniProt/SwissProt for HINFP Gene:
Q9BQA5-HINFP_HUMANEvidence on tissue expression from TISSUES for HINFP Gene
- Lung(4.3)
- Eye(4.1)
- Nervous system(3.7)
Primer Products
-
OriGene qPCR primer pairs and template standards for HINFP
-
OriGene qPCR primer pairs for HINFP
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HINFP Gene
Orthologs for HINFP Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HINFP 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HINFP 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hinfp 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hinfp 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HINFP 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HINFP 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HINFP 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HINFP 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HINFP 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hinfp 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hinfp 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17829 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F39B2.1 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2689 35 |
|
OneToOne |
- Species where no ortholog for HINFP was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HINFP Gene
(37) SIMAP similar genes for HINFP Gene using alignment to 4 proteins:
No data available for Paralogs for HINFP Gene
Variants for HINFP Gene
| SNP ID | Clin | Chr 11 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000141451 | -- | 119,122,848(+) | CCTGT(C/T)GCGGT | intron-variant, upstream-variant-2KB | |
| rs1000217127 | -- | 119,135,469(+) | AATCA(A/G)GTGGT | downstream-variant-500B | |
| rs1000320731 | -- | 119,131,293(+) | TGTGT(G/T)GCCCA | intron-variant | |
| rs1000492431 | -- | 119,123,076(+) | TGAGC(C/G)CAGAT | intron-variant, upstream-variant-2KB | |
| rs1000726618 | -- | 119,123,050(+) | TTGAA(C/G)CTGGG | intron-variant, upstream-variant-2KB |
Relevant External Links for HINFP Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HINFP
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HINFP Gene
Disorders for HINFP Gene
Relevant External Links for HINFP
No disorders were found for HINFP Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HINFP Gene
Publications for HINFP Gene
- Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. (PMID: 11553631) Sekimata M. … Homma Y. (J. Biol. Chem. 2001) 2 3 4 22 64
- Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF. (PMID: 14752047) Sekimata M. … Homma Y. (Nucleic Acids Res. 2004) 3 4 22 64
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
- The histone gene cell cycle regulator HiNF-P is a unique zinc finger transcription factor with a novel conserved auxiliary DNA-binding motif. (PMID: 18850719) Medina R. … Stein G.S. (Biochemistry 2008) 3 4 64
- The HiNF-P/p220NPAT cell cycle signaling pathway controls nonhistone target genes. (PMID: 17974976) Medina R. … Stein G.S. (Cancer Res. 2007) 3 4 64
Products for HINFP Gene
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- antibodies-online Antibodies for HINFP: See all 39
- antibodies-online Kits for HINFP: See all 3
- antibodies-online Proteins for HINFP: See all 6
- Search antibodies-online for peptides
- GeneTex HINFP antibody for HINFP
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- ViGene Biosciences adenoviral particle packaged cDNA for HINFP gene
- ViGene Biosciences lentiviral particle packaged cDNA for HINFP gene
- ViGene Biosciences ready-to-package AAV shRNAs for HINFP gene
- Search ViGene Biosciences for HINFP
- Santa Cruz Biotechnology (SCBT) Antibodies for HINFP
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- VectorBuilder custom plasmid, inducible vectors for HINFP
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HINFP Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
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