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Aliases for HILS1 Gene

Aliases for HILS1 Gene

  • Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene) 2 3 5
  • Spermatid-Specific Linker Histone H1-Like Protein 3
  • Histone Linker H1 Domain, Spermatid-Specific 1 2
  • H1.9 3

External Ids for HILS1 Gene

Previous GeneCards Identifiers for HILS1 Gene

  • GC17U900024
  • GC17M048723
  • GC17M045603
  • GC17M048248
  • GC17M043617

Summaries for HILS1 Gene

Entrez Gene Summary for HILS1 Gene

  • This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008]

GeneCards Summary for HILS1 Gene

HILS1 (Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene)) is a Pseudogene. Among its related pathways are Transcription_CREM signaling in testis. GO annotations related to this gene include nucleic acid binding and histone binding.

UniProtKB/Swiss-Prot for HILS1 Gene

  • DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

Additional gene information for HILS1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HILS1 Gene

Genomics for HILS1 Gene

Regulatory Elements for HILS1 Gene

Enhancers for HILS1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H050288 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -108.6 -108643 3 TBP BATF BRCA1 RAD21 RFX5 ZNF766 ZNF416 RCOR1 FOS RUNX3 KAT7 COL1A1 HILS1 SGCA ENSG00000253730 MBTD1 DLX3 ENSG00000248172 PPP1R9B TMEM92-AS1
GH17H050099 1.5 Ensembl ENCODE dbSUPER 11.2 +79.6 79576 3 ATF1 FOXA2 MLX ARID4B YY1 ZNF766 GLIS2 SP3 SP5 MXD4 PDK2 ENSG00000262837 ENSG00000253730 SGCA HILS1 SAMD14 PICART1 ENSG00000250282 ENSG00000275025
GH17H050107 1.4 Ensembl ENCODE dbSUPER 11.1 +70.5 70458 6 ELF3 TBP ARID4B KLF17 THRB RAD21 TCF12 ELK1 EGR1 FOS PDK2 SGCA ENSG00000253730 HILS1 ENSG00000248172 DLX3 SAMD14 ACSF2 CHAD PICART1
GH17H050216 1.4 Ensembl ENCODE dbSUPER 10.6 -38.7 -38653 6 ARID4B YY1 SCRT2 RCOR1 FOS ATF7 IKZF2 USF2 CEBPB NR2F2 TMEM92 TMEM92-AS1 HILS1 ENSG00000253730 SGCA SAMD14 PDK2 ENSG00000250282 ACSF2 CHAD
GH17H050132 1.1 ENCODE dbSUPER 12.4 +47.9 47932 1 MLX ARID4B DNMT3B THRB GLIS2 FOS CREM SP5 MIER2 KAT8 PDK2 ENSG00000253730 SGCA HILS1 ENSG00000250282 ENSG00000236472 SAMD14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HILS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HILS1 Gene

Chromosome:
17
Start:
50,171,428 bp from pter
End:
50,181,178 bp from pter
Size:
9,751 bases
Orientation:
Minus strand

Genomic View for HILS1 Gene

Genes around HILS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HILS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HILS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HILS1 Gene

Proteins for HILS1 Gene

  • Protein details for HILS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60008-HILS1_HUMAN
    Recommended name:
    Spermatid-specific linker histone H1-like protein
    Protein Accession:
    P60008

    Protein attributes for HILS1 Gene

    Size:
    231 amino acids
    Molecular mass:
    25632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HILS1 Gene

Post-translational modifications for HILS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HILS1 Gene

Domains & Families for HILS1 Gene

Protein Domains for HILS1 Gene

Suggested Antigen Peptide Sequences for HILS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60008

UniProtKB/Swiss-Prot:

HILS1_HUMAN :
  • Belongs to the histone H1/H5 family.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HILS1: view

No data available for Gene Families for HILS1 Gene

Function for HILS1 Gene

Molecular function for HILS1 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

Phenotypes From GWAS Catalog for HILS1 Gene

Gene Ontology (GO) - Molecular Function for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IDA 12920187
GO:0003677 DNA binding IEA --
GO:0042393 histone binding IDA 12920187
genes like me logo Genes that share ontologies with HILS1: view
genes like me logo Genes that share phenotypes with HILS1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HILS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HILS1 Gene

Localization for HILS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HILS1 Gene

Nucleus. Chromosome.

Gene Ontology (GO) - Cellular Components for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 12920187
GO:0001673 male germ cell nucleus IDA 12920187
genes like me logo Genes that share ontologies with HILS1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for HILS1 Gene

Pathways & Interactions for HILS1 Gene

genes like me logo Genes that share pathways with HILS1: view

Pathways by source for HILS1 Gene

1 GeneGo (Thomson Reuters) pathway for HILS1 Gene

Interacting Proteins for HILS1 Gene

Gene Ontology (GO) - Biological Process for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006338 chromatin remodeling NAS 12920187
GO:0006342 chromatin silencing IDA 12920187
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 12920187
genes like me logo Genes that share ontologies with HILS1: view

No data available for SIGNOR curated interactions for HILS1 Gene

Drugs & Compounds for HILS1 Gene

(1) Additional Compounds for HILS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HILS1: view

Transcripts for HILS1 Gene

mRNA/cDNA for HILS1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HILS1 Gene

Histone linker H1 domain, spermatid-specific 1, pseudogene:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HILS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HILS1 Gene

No ASD Table

Relevant External Links for HILS1 Gene

GeneLoc Exon Structure for
HILS1
ECgene alternative splicing isoforms for
HILS1

Expression for HILS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HILS1 Gene

mRNA differential expression in normal tissues according to GTEx for HILS1 Gene

This gene is overexpressed in Testis (x8.4) and Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for HILS1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HILS1 Gene



Protein tissue co-expression partners for HILS1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HILS1 Gene:

HILS1

SOURCE GeneReport for Unigene cluster for HILS1 Gene:

Hs.25934

mRNA Expression by UniProt/SwissProt for HILS1 Gene:

P60008-HILS1_HUMAN
Tissue specificity: Expressed exclusively in the testis.
genes like me logo Genes that share expression patterns with HILS1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HILS1 Gene

Orthologs for HILS1 Gene

Evolution for HILS1 Gene

ENSEMBL:
Gene Tree for HILS1 (if available)
TreeFam:
Gene Tree for HILS1 (if available)

No data available for Orthologs for HILS1 Gene

Paralogs for HILS1 Gene

No data available for Paralogs for HILS1 Gene

Variants for HILS1 Gene

Sequence variations from dbSNP and Humsavar for HILS1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000084672 -- 50,174,040(+) TTGGC(C/T)GGGTG intron-variant, upstream-variant-2KB
rs1001862771 -- 50,173,378(+) GTGGG(C/T)GTGGG intron-variant, upstream-variant-2KB
rs1002158074 -- 50,172,431(+) CTGCA(C/T)GGTGC intron-variant, nc-transcript-variant
rs1002485317 -- 50,171,256(+) GATCA(A/C)GAGGT intron-variant
rs1003100139 -- 50,171,715(+) TGCCG(A/G)TCACC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for HILS1 Gene

Variant ID Type Subtype PubMed ID
nsv507842 OTHER sequence alteration 20534489
nsv952339 CNV deletion 24416366

Relevant External Links for HILS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HILS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HILS1 Gene

Disorders for HILS1 Gene

Relevant External Links for HILS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HILS1

No disorders were found for HILS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HILS1 Gene

Publications for HILS1 Gene

  1. HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis. (PMID: 12920187) Yan W … Matzuk MM (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 22 60
  2. Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. (PMID: 17852044) Jedrzejczak P … Jagodzinski PP (Archives of andrology 2007) 3 22 60
  3. Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells. (PMID: 14636221) Iguchi N … Nishimune Y (International journal of andrology 2003) 3 22 60
  4. Role of H1 linker histones in mammalian development and stem cell differentiation. (PMID: 26689747) Pan C … Fan Y (Biochimica et biophysica acta 2016) 3 60
  5. Mapping of post-translational modifications of spermatid-specific linker histone H1-like protein, HILS1. (PMID: 26257145) Mishra LN … Rao SM (Journal of proteomics 2015) 3 60

Products for HILS1 Gene

Sources for HILS1 Gene

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