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Aliases for HILS1 Gene

Aliases for HILS1 Gene

  • Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene) 2 3
  • Histone Linker H1 Domain, Spermatid-Specific 1, Pseudogene 3 5
  • Spermatid-Specific Linker Histone H1-Like Protein 3
  • Histone Linker H1 Domain, Spermatid-Specific 1 2
  • H1.9 3

External Ids for HILS1 Gene

Previous GeneCards Identifiers for HILS1 Gene

  • GC17U900024
  • GC17M048723
  • GC17M045603
  • GC17M048248
  • GC17M043617

Summaries for HILS1 Gene

Entrez Gene Summary for HILS1 Gene

  • This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008]

GeneCards Summary for HILS1 Gene

HILS1 (Histone Linker H1 Domain, Spermatid-Specific 1 (Pseudogene)) is a Pseudogene. Among its related pathways are Transcription_CREM signaling in testis. GO annotations related to this gene include nucleic acid binding and histone binding.

UniProtKB/Swiss-Prot for HILS1 Gene

  • DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HILS1 Gene

Genomics for HILS1 Gene

Regulatory Elements for HILS1 Gene

Enhancers for HILS1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HILS1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HILS1 Gene

Chromosome:
17
Start:
50,171,428 bp from pter
End:
50,181,178 bp from pter
Size:
9,751 bases
Orientation:
Minus strand

Genomic View for HILS1 Gene

Genes around HILS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HILS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HILS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HILS1 Gene

Proteins for HILS1 Gene

  • Protein details for HILS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60008-HILS1_HUMAN
    Recommended name:
    Spermatid-specific linker histone H1-like protein
    Protein Accession:
    P60008

    Protein attributes for HILS1 Gene

    Size:
    231 amino acids
    Molecular mass:
    25632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HILS1 Gene

Proteomics data for HILS1 Gene at MOPED

Post-translational modifications for HILS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HILS1 Gene

Domains & Families for HILS1 Gene

Protein Domains for HILS1 Gene

Suggested Antigen Peptide Sequences for HILS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60008

UniProtKB/Swiss-Prot:

HILS1_HUMAN :
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
  • Belongs to the histone H1/H5 family.
Domain:
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HILS1: view

No data available for Gene Families for HILS1 Gene

Function for HILS1 Gene

Molecular function for HILS1 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa.
genes like me logo Genes that share phenotypes with HILS1: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HILS1 Gene

Localization for HILS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HILS1 Gene

Nucleus. Chromosome.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HILS1 Gene

Pathways & Interactions for HILS1 Gene

genes like me logo Genes that share pathways with HILS1: view

Pathways by source for HILS1 Gene

1 GeneGo (Thomson Reuters) pathway for HILS1 Gene

Interacting Proteins for HILS1 Gene

Gene Ontology (GO) - Biological Process for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling NAS 12920187
GO:0006342 chromatin silencing IDA 12920187
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development IDA 14636221
GO:0030261 chromosome condensation IDA 12920187
genes like me logo Genes that share ontologies with HILS1: view

No data available for SIGNOR curated interactions for HILS1 Gene

Drugs & Compounds for HILS1 Gene

(1) Additional Compounds for HILS1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HILS1: view

Transcripts for HILS1 Gene

mRNA/cDNA for HILS1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HILS1 Gene

Histone linker H1 domain, spermatid-specific 1, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HILS1 Gene

No ASD Table

Relevant External Links for HILS1 Gene

GeneLoc Exon Structure for
HILS1
ECgene alternative splicing isoforms for
HILS1

Expression for HILS1 Gene

mRNA expression in normal human tissues for HILS1 Gene

mRNA differential expression in normal tissues according to GTEx for HILS1 Gene

This gene is overexpressed in Testis (x8.4) and Muscle - Skeletal (x6.1).

Protein differential expression in normal tissues from HIPED for HILS1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HILS1 Gene



SOURCE GeneReport for Unigene cluster for HILS1 Gene Hs.25934

mRNA Expression by UniProt/SwissProt for HILS1 Gene

P60008-HILS1_HUMAN
Tissue specificity: Expressed exclusively in the testis.
genes like me logo Genes that share expression patterns with HILS1: view

Protein tissue co-expression partners for HILS1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HILS1 Gene

Orthologs for HILS1 Gene

Evolution for HILS1 Gene

ENSEMBL:
Gene Tree for HILS1 (if available)
TreeFam:
Gene Tree for HILS1 (if available)

No data available for Orthologs for HILS1 Gene

Paralogs for HILS1 Gene

No data available for Paralogs for HILS1 Gene

Variants for HILS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HILS1 Gene

Variant ID Type Subtype PubMed ID
nsv908588 CNV Loss 21882294
dgv3225n71 CNV Loss 21882294
nsv507842 CNV Insertion 20534489

Relevant External Links for HILS1 Gene

HapMap Linkage Disequilibrium report
HILS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for HILS1 Gene

Disorders for HILS1 Gene

Relevant External Links for HILS1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HILS1

No disorders were found for HILS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HILS1 Gene

Publications for HILS1 Gene

  1. HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis. (PMID: 12920187) Yan W. … Matzuk M.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23 67
  2. Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. (PMID: 17852044) Jedrzejczak P. … Jagodzinski P.P. (Arch. Androl. 2007) 3 23
  3. Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells. (PMID: 14636221) Iguchi N. … Nishimune Y. (Int. J. Androl. 2003) 3 23
  4. Mapping of post-translational modifications of spermatid-specific linker histone H1-like protein, HILS1. (PMID: 26257145) Mishra L.N. … Rao S.M. (J Proteomics 2015) 3
  5. Rapid evolution of the mammalian HILS1 gene and the nuclear condensation process during mammalian spermiogenesis. (PMID: 23357345) Su Y. … Zhang Y. (J Genet Genomics 2013) 3

Products for HILS1 Gene

Sources for HILS1 Gene

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