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Aliases for HILS1 Gene

Aliases for HILS1 Gene

  • Histone Linker H1 Domain, Spermatid-Specific 1, Pseudogene 2 3
  • Spermatid-Specific Linker Histone H1-Like Protein 3
  • Histone Linker H1 Domain, Spermatid-Specific 1 2
  • H1.9 3

External Ids for HILS1 Gene

Previous GeneCards Identifiers for HILS1 Gene

  • GC17U900024
  • GC17M048723
  • GC17M045603
  • GC17M048248
  • GC17M043617

Summaries for HILS1 Gene

Entrez Gene Summary for HILS1 Gene

  • This locus is the ortholog of a mouse protein-coding gene that displays characteristics of a linker histone and is expressed in nuclei of late maturing spermatids. The human locus is expressed; however, the open reading frame has been disrupted by a frameshift so it is unlikely to encode a functional protein. [provided by RefSeq, Oct 2008]

GeneCards Summary for HILS1 Gene

HILS1 (Histone Linker H1 Domain, Spermatid-Specific 1, Pseudogene) is a Pseudogene. Among its related pathways are Transcription_CREM signaling in testis. GO annotations related to this gene include nucleic acid binding and histone binding.

UniProtKB/Swiss-Prot for HILS1 Gene

  • DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HILS1 Gene

Genomics for HILS1 Gene

Regulatory Elements for HILS1 Gene

Genomic Location for HILS1 Gene

Start:
50,171,428 bp from pter
End:
50,181,178 bp from pter
Size:
9,751 bases
Orientation:
Minus strand

Genomic View for HILS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HILS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HILS1 Gene

Proteins for HILS1 Gene

  • Protein details for HILS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60008-HILS1_HUMAN
    Recommended name:
    Spermatid-specific linker histone H1-like protein
    Protein Accession:
    P60008
    Secondary Accessions:

    Protein attributes for HILS1 Gene

    Size:
    231 amino acids
    Molecular mass:
    25632 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HILS1 Gene

Proteomics data for HILS1 Gene at MOPED

Post-translational modifications for HILS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HILS1 Gene

Domains for HILS1 Gene

Protein Domains for HILS1 Gene

Suggested Antigen Peptide Sequences for HILS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P60008

UniProtKB/Swiss-Prot:

HILS1_HUMAN :
  • P60008
Domain:
  • Contains 1 H15 (linker histone H1/H5 globular) domain.
Family:
  • Belongs to the histone H1/H5 family.
genes like me logo Genes that share domains with HILS1: view

No data available for Gene Families for HILS1 Gene

Function for HILS1 Gene

Molecular function for HILS1 Gene

UniProtKB/Swiss-Prot Function: DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa

Gene Ontology (GO) - Molecular Function for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IDA 12920187
GO:0003677 DNA binding IEA --
GO:0042393 histone binding IDA 12920187
genes like me logo Genes that share ontologies with HILS1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HILS1 Gene

Localization for HILS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HILS1 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HILS1 Gene COMPARTMENTS Subcellular localization image for HILS1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000786 nucleosome IDA 12920187
GO:0001673 male germ cell nucleus IDA 12920187
genes like me logo Genes that share ontologies with HILS1: view

Pathways for HILS1 Gene

genes like me logo Genes that share pathways with HILS1: view

Pathways by source for HILS1 Gene

1 GeneGo (Thomson Reuters) pathway for HILS1 Gene

Interacting Proteins for HILS1 Gene

Gene Ontology (GO) - Biological Process for HILS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly IEA --
GO:0006338 chromatin remodeling NAS 12920187
GO:0006342 chromatin silencing IDA 12920187
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 12920187
genes like me logo Genes that share ontologies with HILS1: view

Compounds for HILS1 Gene

(1) Novoseek inferred chemical compound relationships for HILS1 Gene

Compound -log(P) Hits PubMed IDs
protamine 73.1 2
genes like me logo Genes that share compounds with HILS1: view

Transcripts for HILS1 Gene

mRNA/cDNA for HILS1 Gene

(18) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HILS1 Gene

Histone linker H1 domain, spermatid-specific 1, pseudogene:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HILS1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HILS1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HILS1 Gene

No ASD Table

Relevant External Links for HILS1 Gene

GeneLoc Exon Structure for
HILS1
ECgene alternative splicing isoforms for
HILS1

Expression for HILS1 Gene

mRNA expression in normal human tissues for HILS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HILS1 Gene

This gene is overexpressed in Testis (8.4) and Muscle - Skeletal (6.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HILS1 Gene

SOURCE GeneReport for Unigene cluster for HILS1 Gene Hs.25934

mRNA Expression by UniProt/SwissProt for HILS1 Gene

P60008-HILS1_HUMAN
Tissue specificity: Expressed exclusively in the testis
genes like me logo Genes that share expressions with HILS1: view

In Situ Assay Products

Orthologs for HILS1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HILS1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Hils1 16
Species with no ortholog for HILS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HILS1 Gene

ENSEMBL:
Gene Tree for HILS1 (if available)
TreeFam:
Gene Tree for HILS1 (if available)

Paralogs for HILS1 Gene

No data available for Paralogs for HILS1 Gene

Variants for HILS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for HILS1 Gene

Variant ID Type Subtype PubMed ID
nsv908588 CNV Loss 21882294
dgv3225n71 CNV Loss 21882294
nsv507842 CNV Insertion 20534489

Relevant External Links for HILS1 Gene

HapMap Linkage Disequilibrium report
HILS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HILS1 Gene

Disorders for HILS1 Gene

No disorders were found for HILS1 Gene.

No data available for UniProtKB/Swiss-Prot for HILS1 Gene

Publications for HILS1 Gene

  1. HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis. (PMID: 12920187) Yan W. … Matzuk M.M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 23
  2. Isolation and characterization of a novel cDNA encoding a DNA-binding protein (Hils1) specifically expressed in testicular haploid germ cells. (PMID: 14636221) Iguchi N. … Nishimune Y. (Int. J. Androl. 2003) 3 23
  3. Quantitative assessment of transition proteins 1, 2 spermatid-specific linker histone H1-like protein transcripts in spermatozoa from normozoospermic and asthenozoospermic men. (PMID: 17852044) Jedrzejczak P. … Jagodzinski P.P. (Arch. Androl. 2007) 3 23
  4. Association between fertilin beta, protamines 1 and 2 and spermatid-specific linker histone H1-like protein mRNA levels, fertilization ability of human spermatozoa, and quality of preimplantation embryos. (PMID: 18292840) Depa-MartynA^w M. … Jedrzejczak P. (Folia Histochem. Cytobiol. 2007) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for HILS1 Gene

Sources for HILS1 Gene

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