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Aliases for HILPDA Gene

Aliases for HILPDA Gene

  • Hypoxia Inducible Lipid Droplet Associated 2 3
  • Hypoxia Inducible Lipid Droplet-Associated 2 3 5
  • Hypoxia-Inducible Gene 2 Protein 3 4
  • Hypoxia Inducible Gene 2 2 3
  • C7orf68 3 4
  • HIG2 3 4
  • Chromosome 7 Open Reading Frame 68 2
  • Hypoxia-Inducible Protein 2 3
  • HIG-2 3

External Ids for HILPDA Gene

Previous HGNC Symbols for HILPDA Gene

  • C7orf68

Previous GeneCards Identifiers for HILPDA Gene

  • GC07P128109
  • GC07P128112
  • GC07P128115
  • GC07P128117
  • GC07P128123
  • GC07P128461
  • GC07P128523

Summaries for HILPDA Gene

GeneCards Summary for HILPDA Gene

HILPDA (Hypoxia Inducible Lipid Droplet Associated) is a Protein Coding gene. Diseases associated with HILPDA include hypoxia and renal cell carcinoma. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for HILPDA Gene

  • Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HILPDA Gene

Genomics for HILPDA Gene

Regulatory Elements for HILPDA Gene

Promoters for HILPDA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HILPDA on UCSC Golden Path with GeneCards custom track

Genomic Location for HILPDA Gene

Chromosome:
7
Start:
128,455,830 bp from pter
End:
128,458,418 bp from pter
Size:
2,589 bases
Orientation:
Plus strand

Genomic View for HILPDA Gene

Genes around HILPDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HILPDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HILPDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HILPDA Gene

Proteins for HILPDA Gene

  • Protein details for HILPDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5L2-HLPDA_HUMAN
    Recommended name:
    Hypoxia-inducible lipid droplet-associated protein
    Protein Accession:
    Q9Y5L2
    Secondary Accessions:
    • A4D0Z5
    • Q52LY5
    • Q53HJ7

    Protein attributes for HILPDA Gene

    Size:
    63 amino acids
    Molecular mass:
    6950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HILPDA Gene

Proteomics data for HILPDA Gene at MOPED

Post-translational modifications for HILPDA Gene

  • Glycosylation at Thr 49, Thr 52, Ser 60, and Ser 62
  • Modification sites at PhosphoSitePlus

Other Protein References for HILPDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HILPDA Gene

Domains & Families for HILPDA Gene

Protein Domains for HILPDA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HILPDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HILPDA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HILPDA Gene

Function for HILPDA Gene

Molecular function for HILPDA Gene

UniProtKB/Swiss-Prot Function:
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
UniProtKB/Swiss-Prot Induction:
By hypoxia but highly abundant under normoxic conditions (at protein level).
genes like me logo Genes that share phenotypes with HILPDA: view

Animal Models for HILPDA Gene

MGI Knock Outs for HILPDA:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HILPDA Gene

Localization for HILPDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HILPDA Gene

Lipid droplet. Secreted. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HILPDA Gene COMPARTMENTS Subcellular localization image for HILPDA gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid particle IDA 20624928
GO:0030141 secretory granule IDA 15930302
genes like me logo Genes that share ontologies with HILPDA: view

Pathways & Interactions for HILPDA Gene

SuperPathways for HILPDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 20624928
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006950 response to stress NAS 10690527
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with HILPDA: view

No data available for Pathways by source and SIGNOR curated interactions for HILPDA Gene

Drugs & Compounds for HILPDA Gene

No Compound Related Data Available

Transcripts for HILPDA Gene

Unigene Clusters for HILPDA Gene

Hypoxia inducible lipid droplet-associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HILPDA Gene

No ASD Table

Relevant External Links for HILPDA Gene

GeneLoc Exon Structure for
HILPDA
ECgene alternative splicing isoforms for
HILPDA

Expression for HILPDA Gene

mRNA expression in normal human tissues for HILPDA Gene

mRNA differential expression in normal tissues according to GTEx for HILPDA Gene

This gene is overexpressed in Whole Blood (x6.5) and Esophagus - Mucosa (x5.3).

Protein differential expression in normal tissues from HIPED for HILPDA Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HILPDA Gene



SOURCE GeneReport for Unigene cluster for HILPDA Gene Hs.706124

mRNA Expression by UniProt/SwissProt for HILPDA Gene

Q9Y5L2-HLPDA_HUMAN
Tissue specificity: Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level).
genes like me logo Genes that share expression patterns with HILPDA: view

Protein tissue co-expression partners for HILPDA Gene

Primer Products

In Situ Assay Products

Orthologs for HILPDA Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HILPDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HILPDA 35
  • 99.47 (n)
  • 100 (a)
HILPDA 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hilpda 16
Hilpda 36
  • 77 (a)
OneToOne
Hilpda 35
  • 77.78 (n)
  • 77.78 (a)
rat
(Rattus norvegicus)
Mammalia Hilpda 35
  • 77.78 (n)
  • 73.02 (a)
Species with no ortholog for HILPDA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HILPDA Gene

ENSEMBL:
Gene Tree for HILPDA (if available)
TreeFam:
Gene Tree for HILPDA (if available)

Paralogs for HILPDA Gene

No data available for Paralogs for HILPDA Gene

Variants for HILPDA Gene

Variation tolerance for HILPDA Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HILPDA Gene

HapMap Linkage Disequilibrium report
HILPDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HILPDA Gene

Disorders for HILPDA Gene

MalaCards: The human disease database

(2) MalaCards diseases for HILPDA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypoxia
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HILPDA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HILPDA
genes like me logo Genes that share disorders with HILPDA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HILPDA Gene

Publications for HILPDA Gene

  1. Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. (PMID: 15930302) Togashi A. … Nakamura Y. (Cancer Res. 2005) 2 3 4 23 67
  2. Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas. (PMID: 20134266) Nishimura S. … Aoki D. (Int. J. Gynecol. Cancer 2010) 3 23
  3. Over expression of hypoxia-inducible protein 2, hypoxia-inducible factor-1alpha and nuclear factor kappaB is putatively involved in acquired renal cyst formation and subsequent tumor transformation in patients with end stage renal failure. (PMID: 18550099) Konda R. … Fujioka T. (J. Urol. 2008) 3 23
  4. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. (PMID: 10690527) Denko N.C. … Giaccia A.J. (Clin. Cancer Res. 2000) 2 3
  5. Hypoxia-inducible lipid droplet-associated (HILPDA) is a novel peroxisome proliferator-activated receptor (PPAR) target involved in hepatic triglyceride secretion. (PMID: 24876382) Mattijssen F. … Kersten S. (J. Biol. Chem. 2014) 3

Products for HILPDA Gene

Sources for HILPDA Gene

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