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Aliases for HILPDA Gene

Aliases for HILPDA Gene

  • Hypoxia Inducible Lipid Droplet-Associated 2 3
  • Hypoxia-Inducible Gene 2 Protein 3 4
  • Hypoxia Inducible Gene 2 2 3
  • C7orf68 3 4
  • HIG2 3 4
  • Hypoxia-Inducible Lipid Droplet-Associated Protein 3
  • Chromosome 7 Open Reading Frame 68 2
  • Hypoxia-Inducible Protein 2 3
  • HIG-2 3

External Ids for HILPDA Gene

Previous Symbols for HILPDA Gene

  • C7orf68

Summaries for HILPDA Gene

GeneCards Summary for HILPDA Gene

HILPDA (Hypoxia Inducible Lipid Droplet-Associated) is a Protein Coding gene. Diseases associated with HILPDA include hypoxia and mantle cell lymphoma. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for HILPDA Gene

  • Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HILPDA Gene

Genomics for HILPDA Gene

Genomic Location for HILPDA Gene

128,455,830 bp from pter
128,458,418 bp from pter
2,589 bases
Plus strand

Genomic View for HILPDA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HILPDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HILPDA Gene

No data available for Regulatory Elements for HILPDA Gene

Proteins for HILPDA Gene

  • Protein details for HILPDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hypoxia-inducible lipid droplet-associated protein
    Protein Accession:
    Secondary Accessions:
    • A4D0Z5
    • Q52LY5
    • Q53HJ7

    Protein attributes for HILPDA Gene

    63 amino acids
    Molecular mass:
    6950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HILPDA Gene

Proteomics data for HILPDA Gene at MOPED

Post-translational modifications for HILPDA Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser44, Thr49, Thr52, Ser60, and Ser62

Other Protein References for HILPDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HILPDA Gene

Domains for HILPDA Gene

Protein Domains for HILPDA Gene

genes like me logo Genes that share domains with HILPDA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HILPDA Gene

Function for HILPDA Gene

Molecular function for HILPDA Gene

UniProtKB/Swiss-Prot Function: Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
UniProtKB/Swiss-Prot Induction: By hypoxia but highly abundant under normoxic conditions (at protein level).

Gene Ontology (GO) - Molecular Function for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 15930302
GO:0005515 protein binding IPI 15930302
genes like me logo Genes that share ontologies with HILPDA: view

Phenotypes for HILPDA Gene

MGI mutant phenotypes for HILPDA:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with HILPDA: view

Animal Models for HILPDA Gene

MGI Knock Outs for HILPDA:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HILPDA Gene

Localization for HILPDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HILPDA Gene

Lipid droplet. Secreted. Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 15930302
GO:0005811 lipid particle IDA 20624928
GO:0009986 cell surface IDA 15930302
GO:0016021 integral component of membrane IEA --
GO:0030141 secretory granule IDA 15930302
genes like me logo Genes that share ontologies with HILPDA: view

Pathways for HILPDA Gene

SuperPathways for HILPDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 20624928
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006950 response to stress NAS 10690527
GO:0008284 positive regulation of cell proliferation IDA 15930302
GO:0010884 positive regulation of lipid storage IDA 20624928
genes like me logo Genes that share ontologies with HILPDA: view

No data available for Pathways by source for HILPDA Gene

Transcripts for HILPDA Gene

Unigene Clusters for HILPDA Gene

Hypoxia inducible lipid droplet-associated:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HILPDA Gene

No ASD Table

Relevant External Links for HILPDA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HILPDA Gene

mRNA expression in normal human tissues for HILPDA Gene

mRNA differential expression in normal tissues according to GTEx for HILPDA Gene

This gene is overexpressed in Whole Blood (6.5) and Esophagus - Mucosa (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HILPDA Gene

SOURCE GeneReport for Unigene cluster for HILPDA Gene Hs.706124

mRNA Expression by UniProt/SwissProt for HILPDA Gene

Tissue specificity: Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level).
genes like me logo Genes that share expressions with HILPDA: view

Orthologs for HILPDA Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HILPDA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HILPDA 36
  • 99.47 (n)
  • 100 (a)
  • 100 (a)
(Mus musculus)
Mammalia Hilpda 36
  • 77.78 (n)
  • 77.78 (a)
Hilpda 16
Hilpda 37
  • 77 (a)
(Rattus norvegicus)
Mammalia Hilpda 36
  • 77.78 (n)
  • 73.02 (a)
Species with no ortholog for HILPDA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HILPDA Gene

Gene Tree for HILPDA (if available)
Gene Tree for HILPDA (if available)

Paralogs for HILPDA Gene

No data available for Paralogs for HILPDA Gene

Variants for HILPDA Gene

Sequence variations from dbSNP and Humsavar for HILPDA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1048531 -- 128,458,017(+) ATGCT(A/G)TGCTT utr-variant-3-prime
rs1560215 -- 128,458,147(+) TTATG(A/C)TCAAT utr-variant-3-prime
rs2288554 -- 128,455,789(+) TCCCG(A/G)GCGTG upstream-variant-2KB
rs2288555 -- 128,455,825(+) GTACC(C/G)TCCTG upstream-variant-2KB
rs2288556 -- 128,455,993(+) ACAGC(C/T)GGCGA intron-variant, utr-variant-5-prime

Relevant External Links for HILPDA Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for HILPDA Gene

Disorders for HILPDA Gene

genes like me logo Genes that share disorders with HILPDA: view

No data available for UniProtKB/Swiss-Prot for HILPDA Gene

Publications for HILPDA Gene

  1. Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. (PMID: 15930302) Togashi A. … Nakamura Y. (Cancer Res. 2005) 2 3 4 23
  2. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. (PMID: 10690527) Denko N.C. … Giaccia A.J. (Clin. Cancer Res. 2000) 2 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Over expression of hypoxia-inducible protein 2, hypoxia-inducible factor-1alpha and nuclear factor kappaB is putatively involved in acquired renal cyst formation and subsequent tumor transformation in patients with end stage renal failure. (PMID: 18550099) Konda R. … Fujioka T. (J. Urol. 2008) 3 23

Products for HILPDA Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate HILPDA
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for HILPDA
    • Block miRNA regulation of HILPDA using miScript Target Protectors

    Sources for HILPDA Gene

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