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Aliases for HILPDA Gene

Aliases for HILPDA Gene

  • Hypoxia Inducible Lipid Droplet Associated 2 3 5
  • Hypoxia-Inducible Gene 2 Protein 3 4
  • Hypoxia Inducible Gene 2 2 3
  • C7orf68 3 4
  • HIG2 3 4
  • Hypoxia-Inducible Lipid Droplet-Associated Protein 3
  • Hypoxia Inducible Lipid Droplet-Associated 2
  • Chromosome 7 Open Reading Frame 68 2
  • Hypoxia-Inducible Protein 2 3
  • HIG-2 3

External Ids for HILPDA Gene

Previous HGNC Symbols for HILPDA Gene

  • C7orf68

Previous GeneCards Identifiers for HILPDA Gene

  • GC07P128109
  • GC07P128112
  • GC07P128115
  • GC07P128117
  • GC07P128123
  • GC07P128461
  • GC07P128523
  • GC07P128541
  • GC07P128560

Summaries for HILPDA Gene

GeneCards Summary for HILPDA Gene

HILPDA (Hypoxia Inducible Lipid Droplet Associated) is a Protein Coding gene. Diseases associated with HILPDA include Hypoxia and Renal Cell Carcinoma. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for HILPDA Gene

  • Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HILPDA Gene

Genomics for HILPDA Gene

Regulatory Elements for HILPDA Gene


Enhancers around HILPDA on UCSC Golden Path with GeneCards custom track

Promoters for HILPDA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000634030 170 2001 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 SLC30A9 CBX5 ZNF143

Genomic Location for HILPDA Gene

Chromosome:
7
Start:
128,455,830 bp from pter
End:
128,458,418 bp from pter
Size:
2,589 bases
Orientation:
Plus strand

Genomic View for HILPDA Gene

Genes around HILPDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HILPDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HILPDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HILPDA Gene

Proteins for HILPDA Gene

  • Protein details for HILPDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5L2-HLPDA_HUMAN
    Recommended name:
    Hypoxia-inducible lipid droplet-associated protein
    Protein Accession:
    Q9Y5L2
    Secondary Accessions:
    • A4D0Z5
    • Q52LY5
    • Q53HJ7

    Protein attributes for HILPDA Gene

    Size:
    63 amino acids
    Molecular mass:
    6950 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HILPDA Gene

Post-translational modifications for HILPDA Gene

  • Glycosylation at Thr 49, Thr 52, Ser 60, and Ser 62
  • Modification sites at PhosphoSitePlus

Other Protein References for HILPDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HILPDA Gene

Domains & Families for HILPDA Gene

Protein Domains for HILPDA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HILPDA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HILPDA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HILPDA Gene

Function for HILPDA Gene

Molecular function for HILPDA Gene

UniProtKB/Swiss-Prot Function:
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
UniProtKB/Swiss-Prot Induction:
By hypoxia but highly abundant under normoxic conditions (at protein level).

Gene Ontology (GO) - Molecular Function for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 15930302
GO:0005515 protein binding IPI 15930302
genes like me logo Genes that share ontologies with HILPDA: view
genes like me logo Genes that share phenotypes with HILPDA: view

Animal Models for HILPDA Gene

MGI Knock Outs for HILPDA:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HILPDA Gene

Localization for HILPDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for HILPDA Gene

Lipid droplet. Secreted. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HILPDA gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 4

Gene Ontology (GO) - Cellular Components for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 15930302
GO:0005811 lipid particle IEA,IDA 20624928
GO:0009986 cell surface IDA 15930302
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with HILPDA: view

Pathways & Interactions for HILPDA Gene

genes like me logo Genes that share pathways with HILPDA: view

Pathways by source for HILPDA Gene

Gene Ontology (GO) - Biological Process for HILPDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 20624928
GO:0006950 response to stress NAS 10690527
GO:0008284 positive regulation of cell proliferation IDA 15930302
GO:0010884 positive regulation of lipid storage IDA 20624928
GO:0035425 autocrine signaling IDA 15930302
genes like me logo Genes that share ontologies with HILPDA: view

No data available for SIGNOR curated interactions for HILPDA Gene

Transcripts for HILPDA Gene

Unigene Clusters for HILPDA Gene

Hypoxia inducible lipid droplet-associated:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HILPDA Gene

No ASD Table

Relevant External Links for HILPDA Gene

GeneLoc Exon Structure for
HILPDA
ECgene alternative splicing isoforms for
HILPDA

Expression for HILPDA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HILPDA Gene

mRNA differential expression in normal tissues according to GTEx for HILPDA Gene

This gene is overexpressed in Whole Blood (x6.5) and Esophagus - Mucosa (x5.3).

Protein differential expression in normal tissues from HIPED for HILPDA Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HILPDA Gene



Protein tissue co-expression partners for HILPDA Gene

NURSA nuclear receptor signaling pathways regulating expression of HILPDA Gene:

HILPDA

SOURCE GeneReport for Unigene cluster for HILPDA Gene:

Hs.706124

mRNA Expression by UniProt/SwissProt for HILPDA Gene:

Q9Y5L2-HLPDA_HUMAN
Tissue specificity: Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level).
genes like me logo Genes that share expression patterns with HILPDA: view

Primer Products

Orthologs for HILPDA Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for HILPDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HILPDA 34 35
  • 99.47 (n)
mouse
(Mus musculus)
Mammalia Hilpda 34 16 35
  • 77.78 (n)
rat
(Rattus norvegicus)
Mammalia Hilpda 34
  • 77.78 (n)
Species where no ortholog for HILPDA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HILPDA Gene

ENSEMBL:
Gene Tree for HILPDA (if available)
TreeFam:
Gene Tree for HILPDA (if available)

Paralogs for HILPDA Gene

No data available for Paralogs for HILPDA Gene

Variants for HILPDA Gene

Sequence variations from dbSNP and Humsavar for HILPDA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1048531 -- 128,458,017(+) ATGCT(A/G)TGCTT intron-variant, utr-variant-3-prime
rs10693225 -- 128,455,146(+) AGAAA(-/AG/GA)AATCA intron-variant, upstream-variant-2KB
rs111667863 -- 128,457,817(+) TGAGG(C/T)GGGAG intron-variant, utr-variant-3-prime
rs113041012 -- 128,455,007(+) CCGGG(A/C)GCGGT intron-variant, upstream-variant-2KB
rs11308493 -- 128,454,889(+) GTGGG(-/T)TCGGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HILPDA Gene

Variant ID Type Subtype PubMed ID
nsv831124 CNV gain+loss 17160897
nsv608401 CNV loss 21841781
esv3614970 CNV loss 21293372

Variation tolerance for HILPDA Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HILPDA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HILPDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HILPDA Gene

Disorders for HILPDA Gene

MalaCards: The human disease database

(2) MalaCards diseases for HILPDA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypoxia
renal cell carcinoma
  • renal cell carcinoma, clear cell, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HILPDA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HILPDA
genes like me logo Genes that share disorders with HILPDA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HILPDA Gene

Publications for HILPDA Gene

  1. Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. (PMID: 15930302) Togashi A. … Nakamura Y. (Cancer Res. 2005) 2 3 4 22 64
  2. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. (PMID: 10690527) Denko N.C. … Giaccia A.J. (Clin. Cancer Res. 2000) 2 3 4 64
  3. Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer. (PMID: 21614900) Nishimura S. … Aoki D. (Eur. J. Gynaecol. Oncol. 2011) 3 4 64
  4. Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. (PMID: 20624928) Gimm T. … Warnecke C. (FASEB J. 2010) 3 4 64
  5. Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas. (PMID: 20134266) Nishimura S. … Aoki D. (Int. J. Gynecol. Cancer 2010) 3 22 64

Products for HILPDA Gene

Sources for HILPDA Gene

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