Aliases for HILPDA Gene
Aliases for HILPDA Gene
External Ids for HILPDA Gene
- HGNC: 28859
- Entrez Gene: 29923
- Ensembl: ENSG00000135245
- UniProtKB: Q9Y5L2
Previous HGNC Symbols for HILPDA Gene
- C7orf68
Previous GeneCards Identifiers for HILPDA Gene
- GC07P128109
- GC07P128112
- GC07P128115
- GC07P128117
- GC07P128123
- GC07P128461
- GC07P128523
- GC07P128541
- GC07P128560
- GC07P128576
Summaries for HILPDA Gene
GeneCards Summary for HILPDA Gene
HILPDA (Hypoxia Inducible Lipid Droplet Associated) is a Protein Coding gene. Diseases associated with HILPDA include Hypoxia and Renal Cell Carcinoma. Among its related pathways are Metabolism and Lipoprotein metabolism. GO annotations related to this gene include receptor binding.
UniProtKB/Swiss-Prot for HILPDA Gene
-
Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HILPDA Gene
Genomics for HILPDA Gene
Regulatory Elements for HILPDA Gene
Enhancers for HILPDA Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HILPDA on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HILPDA Gene
- Chromosome:
- 7
- Start:
- 128,455,830 bp from pter
- End:
- 128,458,418 bp from pter
- Size:
- 2,589 bases
- Orientation:
- Plus strand
Genomic View for HILPDA Gene
Genes around HILPDA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q32.1 by Ensembl
- 7q32.1 by Entrez Gene
- 7q32.1 by HGNC
HILPDA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HILPDA Gene
Proteins for HILPDA Gene
-
Protein details for HILPDA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y5L2-HLPDA_HUMAN
- Recommended name:
- Hypoxia-inducible lipid droplet-associated protein
- Protein Accession:
- Q9Y5L2
- A4D0Z5
- Q52LY5
- Q53HJ7
Protein attributes for HILPDA Gene
- Size:
- 63 amino acids
- Molecular mass:
- 6950 Da
- Quaternary structure:
- No Data Available
Protein Expression for HILPDA Gene
Post-translational modifications for HILPDA Gene
Other Protein References for HILPDA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HILPDA
- Invitrogen Antibodies for HILPDA
- antibodies-online Antibodies for HILPDA: See all 11
- GeneTex HILPDA antibody for HILPDA
-
Santa Cruz Biotechnology (SCBT) Antibodies for HILPDA
Protein Products
-
OriGene Purified Proteins for HILPDA
- Search Origene for MassSpec and Protein Over-expression Lysates for HILPDA
- Origene Custom Protein Services for HILPDA
- Novus Biologicals proteins for HILPDA
- Search GeneTex for Proteins for HILPDA
Assay Products
No data available for DME Specific Peptides for HILPDA Gene
Domains & Families for HILPDA Gene
Protein Domains for HILPDA Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HILPDA Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HILPDA Gene
Function for HILPDA Gene
Molecular function for HILPDA Gene
- UniProtKB/Swiss-Prot Function:
- Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation.
- UniProtKB/Swiss-Prot Induction:
- By hypoxia but highly abundant under normoxic conditions (at protein level).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | receptor binding | IPI | 15930302 |
| GO:0005515 | protein binding | IPI | 15930302 |
Phenotypes for HILPDA Gene
- MGI mutant phenotypes for HILPDA:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HILPDA:
Animal Models for HILPDA Gene
- MGI Knock Outs for HILPDA:
-
- Hilpda tm1.1Nat
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HILPDA gene
- Search ViGene Biosciences for HILPDA
CRISPR Products
-
OriGene CRISPR knockouts for HILPDA
-
Santa Cruz Biotechnology (SCBT) CRISPR for HILPDA
- GenScript: Design CRISPR guide RNA sequences for HILPDA
miRNA for HILPDA Gene
- miRTarBase miRNAs that target HILPDA
-
- hsa-mir-150-5p (MIRT392627)
- hsa-mir-651-5p (MIRT491080)
- hsa-mir-1324 (MIRT491081)
- hsa-mir-6876-5p (MIRT491082)
- hsa-mir-296-3p (MIRT491083)
- hsa-mir-4476 (MIRT491084)
- hsa-mir-5683 (MIRT491085)
- hsa-mir-640 (MIRT679595)
- hsa-mir-378a-5p (MIRT679596)
- hsa-mir-6778-3p (MIRT679597)
- hsa-mir-6821-3p (MIRT679598)
- hsa-mir-6790-3p (MIRT679599)
- hsa-mir-3653-5p (MIRT679600)
- hsa-mir-1224-3p (MIRT679601)
- hsa-mir-186-3p (MIRT679602)
- hsa-mir-3934-5p (MIRT679603)
- hsa-mir-764 (MIRT679604)
- hsa-mir-125a-3p (MIRT679605)
miRNA Products
- Search ViGene Biosciences for HILPDA
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HILPDA
- Browse OriGene Inhibitory RNA Products For HILPDA
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Clone Products
- Sino Biological Human cDNA Clone for HILPDA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HILPDA
-
ViGene Biosciences adenoviral particle packaged cDNA for HILPDA gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HILPDA gene
- Search ViGene Biosciences for HILPDA
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HILPDA Gene
Localization for HILPDA Gene
Subcellular locations from UniProtKB/Swiss-Prot for HILPDA Gene
- Lipid droplet. Secreted. Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 4 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005615 | extracellular space | IDA | 15930302 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005811 | lipid particle | IDA,IEA | 20624928 |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for HILPDA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Lipoprotein metabolism | ||
Pathways by source for HILPDA Gene
3 Reactome pathways for HILPDA Gene
Interacting Proteins for HILPDA Gene
Selected Interacting proteins:
ENSP00000257696
Q9Y5L2-HLPDA_HUMAN
for HILPDA Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001819 | positive regulation of cytokine production | IDA | 20624928 |
| GO:0006950 | response to stress | NAS | 10690527 |
| GO:0008284 | positive regulation of cell proliferation | IDA | 15930302 |
| GO:0010884 | positive regulation of lipid storage | IDA | 20624928 |
| GO:0034389 | lipid particle organization | TAS | -- |
No data available for SIGNOR curated interactions for HILPDA Gene
Transcripts for HILPDA Gene
mRNA/cDNA for HILPDA Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (340) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HILPDA Gene
CRISPR Products
-
OriGene CRISPR knockouts for HILPDA
-
Santa Cruz Biotechnology (SCBT) CRISPR for HILPDA
- GenScript: Design CRISPR guide RNA sequences for HILPDA
miRNA Products
- Search ViGene Biosciences for HILPDA
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HILPDA
- Browse OriGene Inhibitory RNA Products For HILPDA
- Search ViGene Biosciences for HILPDA
Clone Products
- Sino Biological Human cDNA Clone for HILPDA
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HILPDA Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
- Umbilical Cord (Extraembryonic Tissues)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for HILPDA Gene
This gene is overexpressed in Whole Blood (x6.5) and Esophagus - Mucosa (x5.3).
This gene is overexpressed in Testis (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HILPDA Gene
NURSA nuclear receptor signaling pathways regulating expression of HILPDA Gene:
HILPDASOURCE GeneReport for Unigene cluster for HILPDA Gene:
Hs.706124mRNA Expression by UniProt/SwissProt for HILPDA Gene:
Q9Y5L2-HLPDA_HUMAN
Tissue specificity:
Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level).
Evidence on tissue expression from TISSUES for HILPDA Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for HILPDA
-
OriGene qPCR primer pairs for HILPDA
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HILPDA Gene
Orthologs for HILPDA Gene
This gene was present in the common ancestor of human and mouse.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HILPDA 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hilpda 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hilpda 34 |
|
- Species where no ortholog for HILPDA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HILPDA Gene
No data available for Paralogs for HILPDA Gene
Variants for HILPDA Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000571520 | -- | 128,458,343(+) | CCTGC(G/T)CAAGT | intron-variant, utr-variant-3-prime | |
| rs1000574946 | -- | 128,458,729(+) | ACTAT(C/T)AGTCC | intron-variant | |
| rs1001792425 | -- | 128,457,997(+) | CTTAC(C/G/T)CCGGG | intron-variant, utr-variant-3-prime | |
| rs1002306584 | -- | 128,454,086(+) | GAATT(C/G)CTGCA | intron-variant, upstream-variant-2KB | |
| rs1002560289 | -- | 128,455,119(+) | TATTT(A/T)AAAAA | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.60;
12.95% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HILPDA Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HILPDA
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HILPDA Gene
Disorders for HILPDA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypoxia |
|
|
| renal cell carcinoma |
|
|
Search HILPDA in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HILPDA
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HILPDA
No data available for UniProtKB/Swiss-Prot and Genatlas for HILPDA Gene
Publications for HILPDA Gene
- Hypoxia-inducible protein 2 (HIG2), a novel diagnostic marker for renal cell carcinoma and potential target for molecular therapy. (PMID: 15930302) Togashi A. … Nakamura Y. (Cancer Res. 2005) 2 3 4 22 64
- Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. (PMID: 10690527) Denko N.C. … Giaccia A.J. (Clin. Cancer Res. 2000) 2 3 4 64
- Expression of hypoxia-inducible 2 (HIG2) protein in uterine cancer. (PMID: 21614900) Nishimura S. … Aoki D. (Eur. J. Gynaecol. Oncol. 2011) 3 4 64
- Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1. (PMID: 20624928) Gimm T. … Warnecke C. (FASEB J. 2010) 3 4 64
- Differential expression of hypoxia-inducible protein 2 among different histological types of epithelial ovarian cancer and in clear cell adenocarcinomas. (PMID: 20134266) Nishimura S. … Aoki D. (Int. J. Gynecol. Cancer 2010) 3 22 64
Products for HILPDA Gene
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- Browse R&D Systems for biochemical assays
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- Search ViGene Biosciences for HILPDA
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- VectorBuilder custom plasmid, inducible vectors for HILPDA
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HILPDA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer