Aliases for HIGD2B Gene
Aliases for HIGD2B Gene
- HIG1 Hypoxia Inducible Domain Family Member 2B 2 3 5
- HIG1 Hypoxia Inducible Domain Family, Member 2B (Pseudogene) 2 3
- HIGD2BP 3 4
- HIG1 Hypoxia Inducible Domain Family, Member 2B 2
- HIG1 Domain Family, Member 2B Pseudogene 3
- HIG1 Domain Family Member 2B Pseudogene 4
- Putative HIG1 Domain Family Member 2B 3
External Ids for HIGD2B Gene
- HGNC: 26984
- Entrez Gene: 123346
- Ensembl: ENSG00000175202
- UniProtKB: Q4VC39
Previous HGNC Symbols for HIGD2B Gene
- HIGD2BP
Previous GeneCards Identifiers for HIGD2B Gene
- GC15M070758
- GC15M072968
- GC15M049798
Summaries for HIGD2B Gene
GeneCards Summary for HIGD2B Gene
HIGD2B (HIG1 Hypoxia Inducible Domain Family Member 2B) is a Protein Coding gene. An important paralog of this gene is HIGD2A.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD2B Gene
Genomics for HIGD2B Gene
Regulatory Elements for HIGD2B Gene
Enhancers for HIGD2B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH15G072835 | 0.7 | ENCODE | 10 | -149.3 | -149312 | 0.6 | CTCF PKNOX1 ETV1 ZNF2 RAD21 ELK1 ZNF143 SMC3 ZNF263 ZNF654 | BBS4 HIGD2B NEO1 ARIH1 ADPGK NPM1P42 |
| GH15G072836 | 0.4 | ENCODE | 10 | -150.9 | -150921 | 1.6 | SCRT2 | HIGD2B BBS4 NEO1 ADPGK NPM1P42 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIGD2B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIGD2B Gene
- Chromosome:
- 15
- Start:
- 72,675,782 bp from pter
- End:
- 72,686,149 bp from pter
- Size:
- 10,368 bases
- Orientation:
- Minus strand
Genomic View for HIGD2B Gene
Genes around HIGD2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q24.1 by Ensembl
- 15q24.1 by Entrez Gene
- 15q24.1 by HGNC
HIGD2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIGD2B Gene
Proteins for HIGD2B Gene
-
Protein details for HIGD2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q4VC39-HIG2B_HUMAN
- Recommended name:
- Putative HIG1 domain family member 2B
- Protein Accession:
- Q4VC39
Protein attributes for HIGD2B Gene
- Size:
- 106 amino acids
- Molecular mass:
- 11405 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HIGD2B Gene
No Post-translational modifications
Other Protein References for HIGD2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HIGD2B
-
Abcam antibodies for HIGD2B
- Search GeneTex for Antibodies for HIGD2B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIGD2B
- Origene Custom Protein Services for HIGD2B
- Novus Biologicals proteins for HIGD2B
- Search GeneTex for Proteins for HIGD2B
Assay Products
No data available for DME Specific Peptides for HIGD2B Gene
Domains & Families for HIGD2B Gene
Protein Domains for HIGD2B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIGD2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HIGD2B Gene
Function for HIGD2B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Search ViGene Biosciences for HIGD2B
CRISPR Products
- Browse CRISPR knockouts for HIGD2B
miRNA Products
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Inhibitory RNA Products
- Origene shRNA and RNAi products in human, mouse, rat for HIGD2B
- Browse OriGene Inhibitory RNA Products For HIGD2B
- Search ViGene Biosciences for HIGD2B
Cell Line Products
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIGD2B Gene
Localization for HIGD2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIGD2B Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for HIGD2B Gene
mRNA/cDNA for HIGD2B Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (2) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIGD2B Gene
CRISPR Products
- Browse CRISPR knockouts for HIGD2B
miRNA Products
- Search ViGene Biosciences for HIGD2B
Inhibitory RNA Products
- Origene shRNA and RNAi products in human, mouse, rat for HIGD2B
- Browse OriGene Inhibitory RNA Products For HIGD2B
- Search ViGene Biosciences for HIGD2B
Flow Cytometry Products
Expression for HIGD2B Gene
mRNA differential expression in normal tissues according to GTEx for HIGD2B Gene
This gene is overexpressed in Testis (x45.5).
NURSA nuclear receptor signaling pathways regulating expression of HIGD2B Gene:
HIGD2BSOURCE GeneReport for Unigene cluster for HIGD2B Gene:
Hs.434111Evidence on tissue expression from TISSUES for HIGD2B Gene
- Nervous system(4.1)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIGD2B Gene
Orthologs for HIGD2B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIGD2B 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Higd2a 35 |
|
OneToMany | |
| cow (Bos Taurus) |
Mammalia | HIGD2A 35 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | -- 35 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| zebrafish (Danio rerio) |
Actinopterygii | higd2a 35 |
|
OneToMany | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG9921 35 |
|
OneToMany |
- Species where no ortholog for HIGD2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HIGD2B Gene
Variants for HIGD2B Gene
| SNP ID | Clin | Chr 15 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs11637927 | Likely benign | 72,686,190(+) | GAAAC(A/C)GCCGA | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs543735239 | Likely benign | 72,686,239(+) | GAGGA(A/G)AGAGT | nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime | |
| rs56368716 | Likely benign | 72,686,211(+) | CGCAG(A/C/T)GGTGG | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs146238636 | Uncertain significance | 72,686,214(+) | AGCGG(A/C/G/T)GGGCT | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs200055760 | Uncertain significance | 72,686,259(+) | GAGCG(C/T)CGAGA | intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2760039 | CNV | gain+loss | 17122850 |
| esv2763105 | CNV | loss | 21179565 |
| nsv1121512 | CNV | deletion | 24896259 |
| nsv1142864 | CNV | tandem duplication | 24896259 |
| nsv428307 | CNV | gain | 18775914 |
| nsv483057 | CNV | loss | 15286789 |
Gene Damage Index Score:
4.35;
63.27% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIGD2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIGD2B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIGD2B Gene
Disorders for HIGD2B Gene
Relevant External Links for HIGD2B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIGD2B
No disorders were found for HIGD2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIGD2B Gene
Publications for HIGD2B Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for HIGD2B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HIGD2B
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- Novus Biologicals Antibodies for HIGD2B
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIGD2B
- VectorBuilder custom plasmid, inducible vectors for HIGD2B
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIGD2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer