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Aliases for HIGD2B Gene

Aliases for HIGD2B Gene

  • HIG1 Hypoxia Inducible Domain Family Member 2B 2 3 5
  • HIG1 Hypoxia Inducible Domain Family, Member 2B (Pseudogene) 2 3
  • HIGD2BP 3 4
  • HIG1 Hypoxia Inducible Domain Family, Member 2B 2
  • HIG1 Domain Family, Member 2B Pseudogene 3
  • HIG1 Domain Family Member 2B Pseudogene 4

External Ids for HIGD2B Gene

Previous HGNC Symbols for HIGD2B Gene


Previous GeneCards Identifiers for HIGD2B Gene

  • GC15M070758
  • GC15M072968
  • GC15M049798

Summaries for HIGD2B Gene

GeneCards Summary for HIGD2B Gene

HIGD2B (HIG1 Hypoxia Inducible Domain Family Member 2B) is a Pseudogene. An important paralog of this gene is HIGD2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD2B Gene

Genomics for HIGD2B Gene

Regulatory Elements for HIGD2B Gene

Enhancers for HIGD2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F072835 0.7 ENCODE 10 -149.3 -149312 0.6 CTCF PKNOX1 ZNF2 RAD21 ELK1 ZNF143 SMC3 ZNF263 ZNF654 ZBTB11 BBS4 HIGD2B NEO1 ARIH1 ADPGK NPM1P42
GH15F072838 0.6 Ensembl 10.1 -152.5 -152452 0.8 ZFHX2 SMARCA4 GLIS1 MAX ZIC2 MYC EGR2 BBS4 HIGD2B NEO1 ADPGK NPM1P42
GH15F072836 0.4 ENCODE 10 -150.9 -150921 1.6 SCRT2 BBS4 HIGD2B NEO1 ADPGK NPM1P42
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIGD2B on UCSC Golden Path with GeneCards custom track

Promoters for HIGD2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000411022 -252 2400 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF263 SP3 SP5 ZHX2

Genomic Location for HIGD2B Gene

72,675,782 bp from pter
72,686,149 bp from pter
10,368 bases
Minus strand

Genomic View for HIGD2B Gene

Genes around HIGD2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIGD2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIGD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIGD2B Gene

Proteins for HIGD2B Gene

  • Protein details for HIGD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative HIG1 domain family member 2B
    Protein Accession:

    Protein attributes for HIGD2B Gene

    106 amino acids
    Molecular mass:
    11405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HIGD2B Gene

Post-translational modifications for HIGD2B Gene

No Post-translational modifications

Other Protein References for HIGD2B Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for HIGD2B Gene

Domains & Families for HIGD2B Gene

Protein Domains for HIGD2B Gene


Suggested Antigen Peptide Sequences for HIGD2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 HIG1 domain.
  • Contains 1 HIG1 domain.
genes like me logo Genes that share domains with HIGD2B: view

No data available for Gene Families for HIGD2B Gene

Function for HIGD2B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIGD2B Gene

Localization for HIGD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIGD2B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIGD2B gene
Compartment Confidence
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HIGD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HIGD2B: view

Pathways & Interactions for HIGD2B Gene

SuperPathways for HIGD2B Gene

No Data Available

Interacting Proteins for HIGD2B Gene

Gene Ontology (GO) - Biological Process for HIGD2B Gene


No data available for Pathways by source and SIGNOR curated interactions for HIGD2B Gene

Transcripts for HIGD2B Gene

mRNA/cDNA for HIGD2B Gene

(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIGD2B Gene

HIG1 hypoxia inducible domain family, member 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIGD2B Gene

No ASD Table

Relevant External Links for HIGD2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIGD2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HIGD2B Gene

mRNA differential expression in normal tissues according to GTEx for HIGD2B Gene

This gene is overexpressed in Testis (x45.5).

NURSA nuclear receptor signaling pathways regulating expression of HIGD2B Gene:


SOURCE GeneReport for Unigene cluster for HIGD2B Gene:

genes like me logo Genes that share expression patterns with HIGD2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HIGD2B Gene

Orthologs for HIGD2B Gene

This gene was present in the common ancestor of animals.

Orthologs for HIGD2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HIGD2B 35
  • 98 (a)
(Mus musculus)
Mammalia Higd2a 35
  • 75 (a)
(Bos Taurus)
Mammalia HIGD2A 35
  • 72 (a)
(Canis familiaris)
Mammalia -- 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 61 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
(Gallus gallus)
Aves -- 35
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
(Danio rerio)
Actinopterygii higd2a 35
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9921 35
  • 42 (a)
Species where no ortholog for HIGD2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIGD2B Gene

Gene Tree for HIGD2B (if available)
Gene Tree for HIGD2B (if available)

Paralogs for HIGD2B Gene

Paralogs for HIGD2B Gene

(4) SIMAP similar genes for HIGD2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIGD2B: view

Variants for HIGD2B Gene

Sequence variations from dbSNP and Humsavar for HIGD2B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs543735239 Likely benign 72,686,239(+) GAGGA(A/G)AGAGT nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs200055760 Uncertain significance 72,686,259(+) GAGCG(C/T)CGAGA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs113994183 Benign 72,686,235(+) GGCTG(A/C)GGAGA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs113994185 Benign 72,686,244(+) GAGAG(C/T)CGCGA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs113994186 Benign 72,686,247(+) AGTCG(C/T)GACGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HIGD2B Gene

Variant ID Type Subtype PubMed ID
nsv483057 CNV loss 15286789
nsv428307 CNV gain 18775914
nsv1142864 CNV tandem duplication 24896259
nsv1121512 CNV deletion 24896259
esv2763105 CNV loss 21179565
esv2760039 CNV gain+loss 17122850

Variation tolerance for HIGD2B Gene

Gene Damage Index Score: 4.35; 63.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIGD2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIGD2B Gene

Disorders for HIGD2B Gene

Relevant External Links for HIGD2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HIGD2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIGD2B Gene

Publications for HIGD2B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for HIGD2B Gene

Sources for HIGD2B Gene

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