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Aliases for HIGD2B Gene

Aliases for HIGD2B Gene

  • HIG1 Hypoxia Inducible Domain Family, Member 2B 2 3
  • HIG1 Hypoxia Inducible Domain Family, Member 2B (Pseudogene) 2 3
  • HIGD2BP 3 4
  • HIG1 Domain Family, Member 2B Pseudogene 3
  • HIG1 Domain Family Member 2B Pseudogene 4

External Ids for HIGD2B Gene

Previous HGNC Symbols for HIGD2B Gene

  • HIGD2BP

Previous GeneCards Identifiers for HIGD2B Gene

  • GC15M070758
  • GC15M072968
  • GC15M049798

Summaries for HIGD2B Gene

GeneCards Summary for HIGD2B Gene

HIGD2B (HIG1 Hypoxia Inducible Domain Family, Member 2B) is a Pseudogene. Diseases associated with HIGD2B include hypoxia. An important paralog of this gene is HIGD2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD2B Gene

Genomics for HIGD2B Gene

Regulatory Elements for HIGD2B Gene

Genomic Location for HIGD2B Gene

Start:
72,675,782 bp from pter
End:
72,686,149 bp from pter
Size:
10,368 bases
Orientation:
Minus strand

Genomic View for HIGD2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIGD2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIGD2B Gene

Proteins for HIGD2B Gene

  • Protein details for HIGD2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VC39-HIG2B_HUMAN
    Recommended name:
    Putative HIG1 domain family member 2B
    Protein Accession:
    Q4VC39
    Secondary Accessions:

    Protein attributes for HIGD2B Gene

    Size:
    106 amino acids
    Molecular mass:
    11405 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HIGD2B Gene

Proteomics data for HIGD2B Gene at MOPED

Post-translational modifications for HIGD2B Gene

No Post-translational modifications

Other Protein References for HIGD2B Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for HIGD2B Gene

Domains for HIGD2B Gene

Protein Domains for HIGD2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HIGD2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4VC39

UniProtKB/Swiss-Prot:

HIG2B_HUMAN :
  • Q4VC39
Domain:
  • Contains 1 HIG1 domain.
genes like me logo Genes that share domains with HIGD2B: view

No data available for Gene Families for HIGD2B Gene

Function for HIGD2B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HIGD2B Gene

Localization for HIGD2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIGD2B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIGD2B Gene COMPARTMENTS Subcellular localization image for HIGD2B gene
Compartment Confidence
cytosol 3
mitochondrion 3
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
golgi apparatus 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HIGD2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HIGD2B: view

Pathways for HIGD2B Gene

SuperPathways for HIGD2B Gene

No Data Available

Interacting Proteins for HIGD2B Gene

Gene Ontology (GO) - Biological Process for HIGD2B Gene

None

No data available for Pathways by source for HIGD2B Gene

Transcripts for HIGD2B Gene

mRNA/cDNA for HIGD2B Gene

(2) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIGD2B Gene

HIG1 hypoxia inducible domain family, member 2B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIGD2B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIGD2B Gene

No ASD Table

Relevant External Links for HIGD2B Gene

GeneLoc Exon Structure for
HIGD2B
ECgene alternative splicing isoforms for
HIGD2B

Expression for HIGD2B Gene

mRNA expression in normal human tissues for HIGD2B Gene

mRNA differential expression in normal tissues according to GTEx for HIGD2B Gene

This gene is overexpressed in Testis (45.5).

SOURCE GeneReport for Unigene cluster for HIGD2B Gene Hs.434111

genes like me logo Genes that share expressions with HIGD2B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for HIGD2B Gene

Orthologs for HIGD2B Gene

This gene was present in the common ancestor of animals.

Orthologs for HIGD2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIGD2A 36
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 67 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Higd2a 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HIGD2B 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii higd2a 36
  • 43 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9921 36
  • 42 (a)
OneToMany
Species with no ortholog for HIGD2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIGD2B Gene

ENSEMBL:
Gene Tree for HIGD2B (if available)
TreeFam:
Gene Tree for HIGD2B (if available)

Paralogs for HIGD2B Gene

Paralogs for HIGD2B Gene

Selected SIMAP similar genes for HIGD2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIGD2B: view

Variants for HIGD2B Gene

Sequence variations from dbSNP and Humsavar for HIGD2B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1991288 -- 72,683,568(+) tgggc(A/G)gggtg intron-variant
rs7175644 -- 72,681,601(+) AAAAT(G/T)TTTTT intron-variant
rs7182789 -- 72,683,102(+) AGTTT(C/T)TCTAG intron-variant
rs8026286 -- 72,683,785(+) gcagt(A/G)agccg intron-variant
rs8026559 -- 72,684,170(+) tgaac(A/T)tgaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIGD2B Gene

Variant ID Type Subtype PubMed ID
dgv755e1 CNV Complex 17122850
nsv428307 CNV Gain 18775914
nsv483057 CNV Loss 15286789

Relevant External Links for HIGD2B Gene

HapMap Linkage Disequilibrium report
HIGD2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIGD2B Gene

Disorders for HIGD2B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HIGD2B Gene in MalaCards »

(1) Diseases for HIGD2B Gene including...

genes like me logo Genes that share disorders with HIGD2B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HIGD2B Gene

Publications for HIGD2B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for HIGD2B Gene

Sources for HIGD2B Gene

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