Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIGD2A Gene

Aliases for HIGD2A Gene

  • HIG1 Hypoxia Inducible Domain Family, Member 2A 2 3
  • HIG1 Domain Family, Member 2A 2 3
  • RCF1 Homolog B 3 4
  • RCF1b 3 4

External Ids for HIGD2A Gene

Previous GeneCards Identifiers for HIGD2A Gene

  • GC05P175749
  • GC05P175750
  • GC05P175815
  • GC05P170740

Summaries for HIGD2A Gene

GeneCards Summary for HIGD2A Gene

HIGD2A (HIG1 Hypoxia Inducible Domain Family, Member 2A) is a Protein Coding gene. An important paralog of this gene is HIGD2B.

UniProtKB/Swiss-Prot for HIGD2A Gene

  • Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD2A Gene

Genomics for HIGD2A Gene

Regulatory Elements for HIGD2A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIGD2A Gene

Chromosome:
5
Start:
176,388,747 bp from pter
End:
176,389,771 bp from pter
Size:
1,025 bases
Orientation:
Plus strand

Genomic View for HIGD2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIGD2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIGD2A Gene

Proteins for HIGD2A Gene

  • Protein details for HIGD2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW72-HIG2A_HUMAN
    Recommended name:
    HIG1 domain family member 2A, mitochondrial
    Protein Accession:
    Q9BW72

    Protein attributes for HIGD2A Gene

    Size:
    106 amino acids
    Molecular mass:
    11529 Da
    Quaternary structure:
    • Associates with cytochrome c oxidase (COX, complex IV); proposed complex component.

neXtProt entry for HIGD2A Gene

Proteomics data for HIGD2A Gene at MOPED

Post-translational modifications for HIGD2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIGD2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIGD2A Gene

Domains & Families for HIGD2A Gene

Protein Domains for HIGD2A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HIGD2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW72

UniProtKB/Swiss-Prot:

HIG2A_HUMAN :
  • Contains 1 HIG1 domain.
Domain:
  • Contains 1 HIG1 domain.
genes like me logo Genes that share domains with HIGD2A: view

No data available for Gene Families for HIGD2A Gene

Function for HIGD2A Gene

Molecular function for HIGD2A Gene

UniProtKB/Swiss-Prot Function:
Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes.
genes like me logo Genes that share phenotypes with HIGD2A: view

Animal Model Products

miRNA for HIGD2A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIGD2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for HIGD2A Gene

Localization for HIGD2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIGD2A Gene

Mitochondrion membrane; Multi-pass membrane protein. Mitochondrion inner membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIGD2A Gene COMPARTMENTS Subcellular localization image for HIGD2A gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for HIGD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with HIGD2A: view

Pathways & Interactions for HIGD2A Gene

SuperPathways for HIGD2A Gene

No Data Available

Interacting Proteins for HIGD2A Gene

Gene Ontology (GO) - Biological Process for HIGD2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043066 negative regulation of apoptotic process IDA 21856340
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with HIGD2A: view

No data available for Pathways by source and SIGNOR curated interactions for HIGD2A Gene

Drugs & Compounds for HIGD2A Gene

No Compound Related Data Available

Transcripts for HIGD2A Gene

mRNA/cDNA for HIGD2A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIGD2A Gene

HIG1 hypoxia inducible domain family, member 2A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIGD2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIGD2A Gene

No ASD Table

Relevant External Links for HIGD2A Gene

GeneLoc Exon Structure for
HIGD2A
ECgene alternative splicing isoforms for
HIGD2A

Expression for HIGD2A Gene

mRNA expression in normal human tissues for HIGD2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIGD2A Gene

This gene is overexpressed in Heart (12.1), Blymphocyte (9.6), Ovary (7.6), and Fetal heart (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for HIGD2A Gene



SOURCE GeneReport for Unigene cluster for HIGD2A Gene Hs.534575

genes like me logo Genes that share expression patterns with HIGD2A: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HIGD2A Gene

Orthologs for HIGD2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HIGD2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HIGD2A 35
  • 84.28 (n)
  • 79.25 (a)
HIGD2A 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LOC479281 35
  • 86.35 (n)
  • 81.9 (a)
-- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Higd2a 35
  • 81.27 (n)
  • 83.81 (a)
Higd2a 16
Higd2a 36
  • 83 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HIGD2A 35
  • 98.74 (n)
  • 99.06 (a)
HIGD2A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Higd2a 35
  • 81.27 (n)
  • 82.86 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves HIGD2A 35
  • 65.9 (n)
  • 60.92 (a)
-- 36
  • 51 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia higd2a 35
  • 65.52 (n)
  • 65.52 (a)
Str.10651 35
zebrafish
(Danio rerio)
Actinopterygii higd2a 35
  • 63.95 (n)
  • 61.22 (a)
higd2a 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG9921 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AIM31 38
Species with no ortholog for HIGD2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIGD2A Gene

ENSEMBL:
Gene Tree for HIGD2A (if available)
TreeFam:
Gene Tree for HIGD2A (if available)

Paralogs for HIGD2A Gene

Paralogs for HIGD2A Gene

(4) SIMAP similar genes for HIGD2A Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for HIGD2A Gene

genes like me logo Genes that share paralogs with HIGD2A: view

Variants for HIGD2A Gene

Variation tolerance for HIGD2A Gene

Residual Variation Intolerance Score: 35.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIGD2A Gene

HapMap Linkage Disequilibrium report
HIGD2A
Human Gene Mutation Database (HGMD)
HIGD2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for HIGD2A Gene

Disorders for HIGD2A Gene

Relevant External Links for HIGD2A

Genetic Association Database (GAD)
HIGD2A
Human Genome Epidemiology (HuGE) Navigator
HIGD2A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIGD2A
genes like me logo Genes that share disorders with HIGD2A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIGD2A Gene

Publications for HIGD2A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  4. Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. (PMID: 22342701) Vukotic M. … Deckers M. (Cell Metab. 2012) 67
  5. The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of caspase activation. (PMID: 21856340) An H.J. … Lee H. (Biochim. Biophys. Acta 2011) 67

Products for HIGD2A Gene

Sources for HIGD2A Gene

Back to Top

Content