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Aliases for HIGD1C Gene

Aliases for HIGD1C Gene

  • HIG1 Hypoxia Inducible Domain Family Member 1C 2 3 5
  • HIG1 Domain Family, Member 1C 2 3
  • HIG1 Hypoxia Inducible Domain Family, Member 1C 2
  • HIG1 Domain Family Member 1C 3
  • GM921 3
  • UBIE2 4
  • UBIE 4

External Ids for HIGD1C Gene

Previous GeneCards Identifiers for HIGD1C Gene

  • GC12U900528
  • GC12P049636
  • GC12P051347
  • GC12P048380

Summaries for HIGD1C Gene

GeneCards Summary for HIGD1C Gene

HIGD1C (HIG1 Hypoxia Inducible Domain Family Member 1C) is a Protein Coding gene. An important paralog of this gene is HIGD1A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD1C Gene

Genomics for HIGD1C Gene

Regulatory Elements for HIGD1C Gene

Enhancers for HIGD1C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G051398 1.2 FANTOM5 Ensembl ENCODE 10.7 +464.0 464040 4.5 CTCF HLF CEBPB ZNF121 TCF12 JUND GLIS1 PRDM10 FOS EGR2 GALNT6 HIGD1C SCN8A SLC4A8 METTL7A ENSG00000271065
GH12G050783 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -149.0 -148973 6.6 FOXA2 PKNOX1 ZNF133 SIN3A BRCA1 GLIS2 ZNF207 FOS ZNF263 JUNB ATF1 CERS5 TFCP2 CSRNP2 BCDIN3D RNU6-1273P SLC11A2 HNRNPA3P10 DIP2B LIMA1
GH12G050936 0.8 ENCODE 0.7 +0.8 810 0.2 HDAC1 CBX3 ATF1 TCF12 ZNF766 GATA2 ZBTB11 ZEB2 MEF2D SMARCA4 SLC11A2 ENSG00000199740 HIGD1C GC12M050941
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIGD1C on UCSC Golden Path with GeneCards custom track

Genomic Location for HIGD1C Gene

Chromosome:
12
Start:
50,936,223 bp from pter
End:
50,972,571 bp from pter
Size:
36,349 bases
Orientation:
Plus strand

Genomic View for HIGD1C Gene

Genes around HIGD1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIGD1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIGD1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIGD1C Gene

Proteins for HIGD1C Gene

  • Protein details for HIGD1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MV81-HIG1C_HUMAN
    Recommended name:
    HIG1 domain family member 1C
    Protein Accession:
    A8MV81

    Protein attributes for HIGD1C Gene

    Size:
    97 amino acids
    Molecular mass:
    11079 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HIGD1C Gene

Post-translational modifications for HIGD1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIGD1C Gene

No data available for DME Specific Peptides for HIGD1C Gene

Domains & Families for HIGD1C Gene

Protein Domains for HIGD1C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HIGD1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HIGD1C: view

No data available for Gene Families and UniProtKB/Swiss-Prot for HIGD1C Gene

Function for HIGD1C Gene

Phenotypes for HIGD1C Gene

GenomeRNAi human phenotypes for HIGD1C:
genes like me logo Genes that share phenotypes with HIGD1C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIGD1C Gene

Localization for HIGD1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIGD1C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIGD1C gene
Compartment Confidence
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HIGD1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HIGD1C: view

Pathways & Interactions for HIGD1C Gene

SuperPathways for HIGD1C Gene

No Data Available

Interacting Proteins for HIGD1C Gene

Gene Ontology (GO) - Biological Process for HIGD1C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HIGD1C Gene

Transcripts for HIGD1C Gene

mRNA/cDNA for HIGD1C Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIGD1C Gene

HIG1 hypoxia inducible domain family, member 1C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIGD1C Gene

No ASD Table

Relevant External Links for HIGD1C Gene

GeneLoc Exon Structure for
HIGD1C
ECgene alternative splicing isoforms for
HIGD1C

Expression for HIGD1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIGD1C Gene

Protein differential expression in normal tissues from HIPED for HIGD1C Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIGD1C Gene



Protein tissue co-expression partners for HIGD1C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HIGD1C Gene:

HIGD1C

SOURCE GeneReport for Unigene cluster for HIGD1C Gene:

Hs.702849
genes like me logo Genes that share expression patterns with HIGD1C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIGD1C Gene

Orthologs for HIGD1C Gene

This gene was present in the common ancestor of animals.

Orthologs for HIGD1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIGD1C 34 35
  • 95.18 (n)
cow
(Bos Taurus)
Mammalia HIGD1C 34 35
  • 93.13 (n)
mouse
(Mus musculus)
Mammalia Higd1c 34 16 35
  • 84.37 (n)
rat
(Rattus norvegicus)
Mammalia LOC102555170 34
  • 84.37 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 56 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HIGD1C 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves HIGD1A 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIGD1C 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia higd1c 34
  • 67.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11825 35
  • 30 (a)
OneToMany
Species where no ortholog for HIGD1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIGD1C Gene

ENSEMBL:
Gene Tree for HIGD1C (if available)
TreeFam:
Gene Tree for HIGD1C (if available)

Paralogs for HIGD1C Gene

Paralogs for HIGD1C Gene

(4) SIMAP similar genes for HIGD1C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIGD1C: view

Variants for HIGD1C Gene

Sequence variations from dbSNP and Humsavar for HIGD1C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000025217 -- 50,938,474(+) ACCGT(A/G)GCTGG intron-variant
rs1000188243 -- 50,955,485(+) CTTGT(A/G)TTCAT intron-variant
rs1000202302 -- 50,948,265(+) GTTAT(C/T)GAATA intron-variant
rs1000302643 -- 50,955,054(+) TGAGA(A/G)GCCGA intron-variant
rs1000389699 -- 50,962,487(+) TTAGG(A/G)TCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIGD1C Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV loss 18971310
esv3629495 CNV loss 21293372
nsv1053466 CNV loss 25217958
nsv1127270 CNV deletion 24896259
nsv1145603 CNV deletion 24896259

Variation tolerance for HIGD1C Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIGD1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIGD1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIGD1C Gene

Disorders for HIGD1C Gene

Relevant External Links for HIGD1C

Genetic Association Database (GAD)
HIGD1C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIGD1C

No disorders were found for HIGD1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIGD1C Gene

Publications for HIGD1C Gene

  1. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) (Nature 2007) 3 46 64
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
  3. A scan for positively selected genes in the genomes of humans and chimpanzees. (PMID: 15869325) Nielsen R. … Cargill M. (PLoS Biol. 2005) 3 64

Products for HIGD1C Gene

Sources for HIGD1C Gene

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