HIGD1C Gene
protein-coding GIFtS: 33
GCID: GC12P051347
|
|
HIG1 hypoxia inducible domain family, member 1C(Previous names: HIG1 domain family, member 1C )
| |
Aliases
for HIGD1C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HIG1 Hypoxia Inducible Domain Family, Member 1C1 2 | | HIG1 Domain Family Member 1C2 | | HIG1 Domain Family, Member 1C1 2 | | UBIE3 | | Gm9211 | | UBIE23 | | GM9212 | | |
Export aliases for HIGD1C gene to outside databasesPrevious GC identifers: GC12U900528 GC12P049636 GC12P048380 |
Summaries
for HIGD1C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for HIGD1C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIGD1C gene promoter:
HEN1 FOXJ2 (long isoform) Brachyury FOXJ2 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIGD1C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIGD1C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12HIGD1C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P051347: view genomic region
(about GC identifiers)
Start:
|
51,347,705 bp from pter |
End:
|
51,364,289 bp from pter |
Size:
|
16,585 bases |
Orientation:
|
plus strand |
|
Proteins
for HIGD1C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIG1C_HUMAN, A8MV81 (See
protein sequence)Recommended Name: HIG1 domain family member 1C Size: 97 amino acids; 11079 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for HIGD1C: NX_A8MV81
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A8MV81
HIGD1C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001103089.1
ENSEMBL proteins: ENSP00000381473
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
HIGD1C for ontologies About GeneDecksing
HIGD1C Antibody Products:
Assay Products for HIGD1C: |
Protein
Domains /
Families
for HIGD1C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIGD1C for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A8MV81ProtoNet protein and cluster: A8MV81 UniProtKB/Swiss-Prot: HIG1C_HUMAN, A8MV81Similarity: Contains 1 HIG1 domain |
Function
for HIGD1C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HIGD1C (NM_001109619) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIGD1C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIGD1C |
|
Pathways & Interactions
for HIGD1C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIGD1C
|
Drugs & Compounds
for HIGD1C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HIGD1C
Search CenterWatch for drugs/clinical trials and news about HIGD1C / HIG1C
|
Transcripts
for HIGD1C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIGD1C gene: NM_001109619.1 Unigene Cluster for HIGD1C: HIG1 hypoxia inducible domain family, member 1C Hs.702849 [show with all ESTs]Unigene Representative Sequence: AA3935791 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000398455(uc010smw.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1C (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1C
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HIGD1C (NM_001109619) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIGD1C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIGD1C |
2 DOTS entries: DT.121127231 DT.425939
GeneLoc Exon Structure
|
Expression
for HIGD1C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIGD1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGTTGCTG
About this image
See HIGD1C Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.702849
SABiosciences Custom PCR Arrays for HIGD1C
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIGD1C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat HIGD1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIGD1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIGD1C |
Orthologs
for HIGD1C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HIGD1C gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for HIGD1C (if available)
TreeFam Gene Tree for HIGD1C (if available) |
Paralogs
for HIGD1C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIGD1C gene
- HIGD1B2 HIGD1A2
4 SIMAP similar genes for HIGD1C using alignment to 1 protein entry: HIG1C_HUMAN:HIGD1A HIGD1B HIGD2A HIGD2B
HIGD1C for paralogs About GeneDecksing
5/9 Pseudogenes.org Pseudogenes for HIGD1C (see all 9)
PGOHUM00000244196 PGOHUM00000244228 PGOHUM00000244233 PGOHUM00000244979 PGOHUM00000244980
|
Genomic Variants
for HIGD1C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIGD1C (51347705 - 51364289 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HIGD1C
1 CNV: 47982 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIGD1C |
|
Disorders
/ Diseases
for HIGD1C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIGD1C for disorders About GeneDecksing
1  disease for HIGD1C: About MalaCardshypoxia
Export disorders for HIGD1C gene to outside databases
|
Publications
for HIGD1C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIGD1C gene integrated from 9 sources:
(articles sorted by number of sources associating them with HIGD1C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PubMed id 17554300)1 . (2007)
- A scan for positively selected genes in the genomes of humans and chimpanzees. (PubMed id 15869325)1 Nielsen R....Cargill M. (2005)
|
External Searches for HIGD1C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIGD1C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIGD1C gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIGD1C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HIGD1C | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HIGD1C gene:
Search GeneIP for patents involving HIGD1C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HIGD1C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HIGD1C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIGD1C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIGD1C | | | OriGene Protein Over-expression Lysate for HIGD1C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIGD1C | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIGD1C | | OriGene Custom Protein Services for HIGD1C | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIGD1C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIGD1C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIGD1C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIGD1C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIGD1C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIGD1C |
| |
 |  |  |  | |
| | | | Search Tocris compounds for HIGD1C |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | HIGD1C Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for HIGD1C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIGD1C |
|
|
|
|
