Aliases for HIGD1C Gene
Aliases for HIGD1C Gene
External Ids for HIGD1C Gene
- HGNC: 28044
- Entrez Gene: 613227
- Ensembl: ENSG00000214511
- UniProtKB: A8MV81
Previous GeneCards Identifiers for HIGD1C Gene
- GC12U900528
- GC12P049636
- GC12P051347
- GC12P048380
Summaries for HIGD1C Gene
GeneCards Summary for HIGD1C Gene
HIGD1C (HIG1 Hypoxia Inducible Domain Family Member 1C) is a Protein Coding gene. An important paralog of this gene is HIGD1A.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD1C Gene
Genomics for HIGD1C Gene
Regulatory Elements for HIGD1C Gene
Enhancers for HIGD1C Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G051398 | 1.2 | FANTOM5 Ensembl ENCODE | 10.7 | +464.0 | 464040 | 4.5 | CTCF HLF CEBPB ZNF121 TCF12 JUND GLIS1 PRDM10 FOS EGR2 | GALNT6 HIGD1C SCN8A SLC4A8 METTL7A ENSG00000271065 |
| GH12G050783 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 2.1 | -149.0 | -148973 | 6.6 | FOXA2 PKNOX1 ZNF133 SIN3A BRCA1 GLIS2 ZNF207 FOS ZNF263 JUNB | ATF1 CERS5 TFCP2 CSRNP2 BCDIN3D RNU6-1273P SLC11A2 HNRNPA3P10 DIP2B LIMA1 |
| GH12G050936 | 0.8 | ENCODE | 0.7 | +0.8 | 810 | 0.2 | HDAC1 CBX3 ATF1 TCF12 ZNF766 GATA2 ZBTB11 ZEB2 MEF2D SMARCA4 | SLC11A2 ENSG00000199740 HIGD1C GC12M050941 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIGD1C on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HIGD1C gene promoter:
Regulatory Element Products
Genomic Location for HIGD1C Gene
- Chromosome:
- 12
- Start:
- 50,936,223 bp from pter
- End:
- 50,972,571 bp from pter
- Size:
- 36,349 bases
- Orientation:
- Plus strand
Genomic View for HIGD1C Gene
Genes around HIGD1C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.12 by Ensembl
- 12q13.12 by Entrez Gene
- 12q13.12 by HGNC
HIGD1C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIGD1C Gene
Proteins for HIGD1C Gene
-
Protein details for HIGD1C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A8MV81-HIG1C_HUMAN
- Recommended name:
- HIG1 domain family member 1C
- Protein Accession:
- A8MV81
Protein attributes for HIGD1C Gene
- Size:
- 97 amino acids
- Molecular mass:
- 11079 Da
- Quaternary structure:
- No Data Available
Protein Expression for HIGD1C Gene
Post-translational modifications for HIGD1C Gene
Other Protein References for HIGD1C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for HIGD1C
Protein Products
-
OriGene Purified Proteins for HIGD1C
- Search Origene for MassSpec and Protein Over-expression Lysates for HIGD1C
- Origene Custom Protein Services for HIGD1C
- Search GeneTex for Proteins for HIGD1C
Assay Products
No data available for DME Specific Peptides for HIGD1C Gene
Domains & Families for HIGD1C Gene
Protein Domains for HIGD1C Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIGD1C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HIGD1C Gene
Function for HIGD1C Gene
Phenotypes for HIGD1C Gene
- GenomeRNAi human phenotypes for HIGD1C:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIGD1C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIGD1C gene
- Search ViGene Biosciences for HIGD1C
CRISPR Products
-
OriGene CRISPR knockouts for HIGD1C
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIGD1C
- GenScript: Design CRISPR guide RNA sequences for HIGD1C
miRNA Products
- Search ViGene Biosciences for HIGD1C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIGD1C
- Browse OriGene Inhibitory RNA Products For HIGD1C
-
ViGene Biosciences ready-to-package AAV shRNAs for HIGD1C gene
Clone Products
-
OriGene ORF clones in human for HIGD1C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HIGD1C
-
ViGene Biosciences adenoviral particle packaged cDNA for HIGD1C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIGD1C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIGD1C gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIGD1C Gene
Localization for HIGD1C Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIGD1C Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for HIGD1C Gene
mRNA/cDNA for HIGD1C Gene
- (5) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIGD1C Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIGD1C
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIGD1C
- GenScript: Design CRISPR guide RNA sequences for HIGD1C
miRNA Products
- Search ViGene Biosciences for HIGD1C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIGD1C
- Browse OriGene Inhibitory RNA Products For HIGD1C
-
ViGene Biosciences ready-to-package AAV shRNAs for HIGD1C gene
Clone Products
-
OriGene ORF clones in human for HIGD1C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HIGD1C Gene
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIGD1C Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HIGD1C Gene:
HIGD1CSOURCE GeneReport for Unigene cluster for HIGD1C Gene:
Hs.702849Primer Products
-
OriGene qPCR primer pairs for HIGD1C
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIGD1C Gene
Orthologs for HIGD1C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIGD1C 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HIGD1C 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Higd1c 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC102555170 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HIGD1C 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HIGD1A 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HIGD1C 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | higd1c 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11825 35 |
|
OneToMany |
- Species where no ortholog for HIGD1C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIGD1C Gene
(4) SIMAP similar genes for HIGD1C Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for HIGD1C Gene
Variants for HIGD1C Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000025217 | -- | 50,938,474(+) | ACCGT(A/G)GCTGG | intron-variant | |
| rs1000188243 | -- | 50,955,485(+) | CTTGT(A/G)TTCAT | intron-variant | |
| rs1000202302 | -- | 50,948,265(+) | GTTAT(C/T)GAATA | intron-variant | |
| rs1000302643 | -- | 50,955,054(+) | TGAGA(A/G)GCCGA | intron-variant | |
| rs1000389699 | -- | 50,962,487(+) | TTAGG(A/G)TCAGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv34039 | CNV | loss | 18971310 |
| esv3629495 | CNV | loss | 21293372 |
| nsv1053466 | CNV | loss | 25217958 |
| nsv1127270 | CNV | deletion | 24896259 |
| nsv1145603 | CNV | deletion | 24896259 |
Residual Variation Intolerance Score:
74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.55% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIGD1C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIGD1C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIGD1C Gene
Disorders for HIGD1C Gene
Relevant External Links for HIGD1C
No disorders were found for HIGD1C Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIGD1C Gene
Publications for HIGD1C Gene
- Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) (Nature 2007) 3 46 64
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64
- A scan for positively selected genes in the genomes of humans and chimpanzees. (PMID: 15869325) Nielsen R. … Cargill M. (PLoS Biol. 2005) 3 64
Products for HIGD1C Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
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- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HIGD1C
- Search Origene for MassSpec and Protein Over-expression Lysates for HIGD1C
- Origene Custom Protein Services for HIGD1C
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HIGD1C
- Browse OriGene Inhibitory RNA Products For HIGD1C
- OriGene qPCR primer pairs for HIGD1C
- OriGene CRISPR knockouts for HIGD1C
- OriGene ORF clones in human for HIGD1C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HIGD1C
- GenScript: Next-day shipping cDNA ORF clone for HIGD1C in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HIGD1C
- GenScript Custom Assay Services for HIGD1C
- GenScript Custom overexpressing Cell Line Services for HIGD1C
- GenScript: Design CRISPR guide RNA sequences for HIGD1C
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for HIGD1C gene
- ViGene Biosciences lentiviral particle packaged cDNA for HIGD1C gene
- ViGene Biosciences ready-to-package AAV shRNAs for HIGD1C gene
- Search ViGene Biosciences for HIGD1C
- Horizon Cell Lines for HIGD1C
- Cyagen custom Knockout/knockin (KOKI) mouse models for HIGD1C
- VectorBuilder custom plasmid, inducible vectors for HIGD1C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HIGD1C
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HIGD1C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer