Aliases for HIGD1B Gene
Aliases for HIGD1B Gene
External Ids for HIGD1B Gene
- HGNC: 24318
- Entrez Gene: 51751
- Ensembl: ENSG00000131097
- UniProtKB: Q9P298
Previous GeneCards Identifiers for HIGD1B Gene
- GC17P040281
- GC17P042925
- GC17P038690
Summaries for HIGD1B Gene
-
This gene encodes a member of the hypoxia inducible gene 1 (HIG1) domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
GeneCards Summary for HIGD1B Gene
HIGD1B (HIG1 Hypoxia Inducible Domain Family Member 1B) is a Protein Coding gene. Diseases associated with HIGD1B include Hypoxia. An important paralog of this gene is HIGD1C.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD1B Gene
Genomics for HIGD1B Gene
Regulatory Elements for HIGD1B Gene
Enhancers for HIGD1B Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HIGD1B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HIGD1B Gene
- Chromosome:
- 17
- Start:
- 44,844,815 bp from pter
- End:
- 44,850,480 bp from pter
- Size:
- 5,666 bases
- Orientation:
- Plus strand
Genomic View for HIGD1B Gene
Genes around HIGD1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC
HIGD1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HIGD1B Gene
Proteins for HIGD1B Gene
-
Protein details for HIGD1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P298-HIG1B_HUMAN
- Recommended name:
- HIG1 domain family member 1B
- Protein Accession:
- Q9P298
- D3DX57
- Q9P297
Protein attributes for HIGD1B Gene
- Size:
- 99 amino acids
- Molecular mass:
- 11058 Da
- Quaternary structure:
- No Data Available
Protein Expression for HIGD1B Gene
Post-translational modifications for HIGD1B Gene
Other Protein References for HIGD1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- antibodies-online Antibodies for HIGD1B: See all 13
- Search GeneTex for Antibodies for HIGD1B
Protein Products
-
OriGene Purified Proteins for HIGD1B
- Search Origene for MassSpec and Protein Over-expression Lysates for HIGD1B
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- Novus Biologicals lysates for HIGD1B
- Search GeneTex for Proteins for HIGD1B
Assay Products
No data available for DME Specific Peptides for HIGD1B Gene
Domains & Families for HIGD1B Gene
Protein Domains for HIGD1B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HIGD1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for HIGD1B Gene
Function for HIGD1B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HIGD1B gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HIGD1B gene
- Search ViGene Biosciences for HIGD1B
CRISPR Products
-
OriGene CRISPR knockouts for HIGD1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIGD1B
- GenScript: Design CRISPR guide RNA sequences for HIGD1B
miRNA Products
- Search ViGene Biosciences for HIGD1B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIGD1B
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-
ViGene Biosciences ready-to-package AAV shRNAs for HIGD1B gene
Cell Line Products
-
Horizon Cell Lines for HIGD1B
-
ViGene Biosciences adenoviral particle packaged cDNA for HIGD1B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HIGD1B gene
-
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Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HIGD1B Gene
Localization for HIGD1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for HIGD1B Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for HIGD1B Gene
mRNA/cDNA for HIGD1B Gene
- (8) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (49) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HIGD1B Gene
CRISPR Products
-
OriGene CRISPR knockouts for HIGD1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for HIGD1B
- GenScript: Design CRISPR guide RNA sequences for HIGD1B
miRNA Products
- Search ViGene Biosciences for HIGD1B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HIGD1B
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-
ViGene Biosciences ready-to-package AAV shRNAs for HIGD1B gene
Flow Cytometry Products
Expression for HIGD1B Gene
mRNA differential expression in normal tissues according to GTEx for HIGD1B Gene
This gene is overexpressed in Heart - Left Ventricle (x4.4) and Brain - Putamen (basal ganglia) (x4.1).
This gene is overexpressed in Placenta (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for HIGD1B Gene
NURSA nuclear receptor signaling pathways regulating expression of HIGD1B Gene:
HIGD1BSOURCE GeneReport for Unigene cluster for HIGD1B Gene:
Hs.287963Primer Products
-
OriGene qPCR primer pairs for HIGD1B
-
OriGene qPCR primer pairs and template standards for HIGD1B
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIGD1B Gene
Orthologs for HIGD1B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HIGD1B 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HIGD1B 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HIGD1B 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Higd1b 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Higd1b 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HIGD1B 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HIGD1B 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | higd1b 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG11825 35 |
|
OneToMany |
- Species where no ortholog for HIGD1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HIGD1B Gene
(4) SIMAP similar genes for HIGD1B Gene using alignment to 3 proteins:
Variants for HIGD1B Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000030781 | -- | 44,844,887(+) | AGTCA(C/T)TAAGC | intron-variant, upstream-variant-2KB | |
| rs1000111504 | -- | 44,848,487(+) | CACCA(A/C)CACCA | intron-variant | |
| rs1001732173 | -- | 44,843,360(+) | CTCTA(A/T)ATCAG | upstream-variant-2KB | |
| rs1002014366 | -- | 44,847,593(+) | TGTGC(A/C)AAATA | intron-variant, upstream-variant-2KB, utr-variant-5-prime | |
| rs1002163240 | -- | 44,843,678(+) | TCTTT(C/T)TTCTG | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2715966 | CNV | deletion | 23290073 |
| nsv1118596 | CNV | duplication | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
Residual Variation Intolerance Score:
63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.32;
76.66% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HIGD1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HIGD1B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIGD1B Gene
Disorders for HIGD1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypoxia |
|
|
Search HIGD1B in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HIGD1B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HIGD1B
No data available for UniProtKB/Swiss-Prot and Genatlas for HIGD1B Gene
Publications for HIGD1B Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PMID: 22609626) Klammt C. … Choe S. (Nat. Methods 2012) 4 64
- Analysis of differential gene expression in plurihormonal pituitary adenomas using bead-based fiber-optic arrays. (PMID: 22588334) Jiang Z. … Zhang Y. (J. Neurooncol. 2012) 3 64
- Analysis of differential gene expression by bead-based fiber-optic array in nonfunctioning pituitary adenomas. (PMID: 21351040) Jiang Z. … Zhang Y. (Horm. Metab. Res. 2011) 3 64
Products for HIGD1B Gene
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Sources for HIGD1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (11) GO
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
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- (28) RNAdb
- (29) ASD
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- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (44) GeneTests
- (45) HGMD
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- (48) BGMUT
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- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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- (55) HORDE
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- (62) NCBI
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- (64) PubMed
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- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
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- (71) Sino Biological
- (72) GenScript
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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- (77) Proteopedia
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- (100) COMPARTMENTS
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