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Aliases for HIGD1B Gene

Aliases for HIGD1B Gene

  • HIG1 Hypoxia Inducible Domain Family, Member 1B 2 3
  • HIG1 Domain Family, Member 1B 2
  • HIG1 Domain Family Member 1B 3
  • Protein CLST 11240 4
  • CLST11240-15 3
  • CLST11240 3

External Ids for HIGD1B Gene

Previous GeneCards Identifiers for HIGD1B Gene

  • GC17P040281
  • GC17P042925
  • GC17P038690

Summaries for HIGD1B Gene

Entrez Gene Summary for HIGD1B Gene

  • This gene encodes a member of the hypoxia inducible gene 1 (HIG1) domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for HIGD1B Gene

HIGD1B (HIG1 Hypoxia Inducible Domain Family, Member 1B) is a Protein Coding gene. Diseases associated with HIGD1B include hypoxia. An important paralog of this gene is HIGD1A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIGD1B Gene

Genomics for HIGD1B Gene

Regulatory Elements for HIGD1B Gene

Genomic Location for HIGD1B Gene

44,845,988 bp from pter
44,850,742 bp from pter
4,755 bases
Plus strand

Genomic View for HIGD1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIGD1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIGD1B Gene

Proteins for HIGD1B Gene

  • Protein details for HIGD1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    HIG1 domain family member 1B
    Protein Accession:
    Secondary Accessions:
    • D3DX57
    • Q9P297

    Protein attributes for HIGD1B Gene

    99 amino acids
    Molecular mass:
    11058 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HIGD1B Gene

neXtProt entry for HIGD1B Gene

Proteomics data for HIGD1B Gene at MOPED

Post-translational modifications for HIGD1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIGD1B Gene

No data available for DME Specific Peptides for HIGD1B Gene

Domains for HIGD1B Gene

Protein Domains for HIGD1B Gene


Suggested Antigen Peptide Sequences for HIGD1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9P298
  • Contains 1 HIG1 domain.
genes like me logo Genes that share domains with HIGD1B: view

No data available for Gene Families for HIGD1B Gene

Function for HIGD1B Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIGD1B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HIGD1B Gene

Localization for HIGD1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIGD1B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for HIGD1B Gene COMPARTMENTS Subcellular localization image for HIGD1B gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HIGD1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with HIGD1B: view

Pathways for HIGD1B Gene

SuperPathways for HIGD1B Gene

No Data Available

Interacting Proteins for HIGD1B Gene

Selected Interacting proteins: Q9P298-HIG1B_HUMAN for HIGD1B Gene via MINT I2D

Gene Ontology (GO) - Biological Process for HIGD1B Gene


No data available for Pathways by source for HIGD1B Gene

Transcripts for HIGD1B Gene

Unigene Clusters for HIGD1B Gene

HIG1 hypoxia inducible domain family, member 1B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIGD1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIGD1B Gene

No ASD Table

Relevant External Links for HIGD1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIGD1B Gene

mRNA expression in normal human tissues for HIGD1B Gene

mRNA differential expression in normal tissues according to GTEx for HIGD1B Gene

This gene is overexpressed in Heart - Left Ventricle (4.4) and Brain - Putamen (basal ganglia) (4.1).

Protein differential expression in normal tissues for HIGD1B Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for HIGD1B Gene

SOURCE GeneReport for Unigene cluster for HIGD1B Gene Hs.287963

genes like me logo Genes that share expressions with HIGD1B: view

Expression partners for HIGD1B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HIGD1B Gene

Orthologs for HIGD1B Gene

This gene was present in the common ancestor of animals.

Orthologs for HIGD1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HIGD1B 35
  • 85.86 (n)
  • 85.86 (a)
  • 86 (a)
(Canis familiaris)
Mammalia HIGD1B 35
  • 85.86 (n)
  • 82.83 (a)
  • 79 (a)
(Mus musculus)
Mammalia Higd1b 35
  • 82.99 (n)
  • 79.17 (a)
Higd1b 16
Higd1b 36
  • 78 (a)
(Pan troglodytes)
Mammalia HIGD1B 35
  • 98.99 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Higd1b 35
  • 83.16 (n)
  • 81.05 (a)
(Monodelphis domestica)
Mammalia HIGD1B 36
  • 53 (a)
(Anolis carolinensis)
Reptilia HIGD1B 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia higd1b 35
  • 57.8 (n)
  • 56.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11825 36
  • 21 (a)
Species with no ortholog for HIGD1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HIGD1B Gene

Gene Tree for HIGD1B (if available)
Gene Tree for HIGD1B (if available)

Paralogs for HIGD1B Gene

Paralogs for HIGD1B Gene

Selected SIMAP similar genes for HIGD1B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HIGD1B: view

Variants for HIGD1B Gene

Sequence variations from dbSNP and Humsavar for HIGD1B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12164 -- 44,848,191(-) TCTTC(A/G)TCGTC reference, synonymous-codon, nc-transcript-variant
rs1867286 -- 44,844,228(+) ATTTC(A/G)GTAGG upstream-variant-2KB
rs2231646 -- 44,849,405(+) TGTGG(A/G/T)GTCGC intron-variant
rs4793162 -- 44,845,640(+) aaaaa(A/C)CCCCA upstream-variant-2KB
rs6503404 -- 44,846,064(+) TTTCT(A/G)CTCAT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HIGD1B Gene

Variant ID Type Subtype PubMed ID
esv2715966 CNV Deletion 23290073

Relevant External Links for HIGD1B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIGD1B Gene

Disorders for HIGD1B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HIGD1B Gene in MalaCards »

(1) Diseases for HIGD1B Gene including...

genes like me logo Genes that share disorders with HIGD1B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HIGD1B Gene

Publications for HIGD1B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Analysis of differential gene expression by bead-based fiber-optic array in nonfunctioning pituitary adenomas. (PMID: 21351040) Jiang Z. … Zhang Y. (Horm. Metab. Res. 2011) 3
  5. Differential gene expression by fiber-optic beadarray and pathway in adrenocorticotrophin-secreting pituitary adenomas. (PMID: 22166531) Jiang Z.Q. … Zhang Y.Z. (Chin. Med. J. 2010) 3

Products for HIGD1B Gene

Sources for HIGD1B Gene

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