HIGD1B Gene
protein-coding GIFtS: 40
GCID: GC17P042925
|
|
HIG1 hypoxia inducible domain family, member 1B(Previous names: HIG1 domain family, member 1B )
| |
Aliases
for HIGD1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HIG1 Hypoxia Inducible Domain Family, Member 1B1 2 | | CLST112401 2 | | CLST11240-151 2 | | HIG1 Domain Family, Member 1B1 | | HIG1 Domain Family Member 1B2 | | Protein CLST 112403 |
Export aliases for HIGD1B gene to outside databasesPrevious GC identifers: GC17P040281 GC17P038690 |
Summaries
for HIGD1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIGD1B:
This gene encodes a member of the hypoxia inducible gene 1 (HIG1) domain family. The encoded protein is localized tothe cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicingresults in multiple transcript variants. (provided by RefSeq, Dec 2012)
|
Genomic Views
for HIGD1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIGD1B gene promoter:
Bach1 GATA-3 Pbx1a AML1a AP-4 GATA-2 GATA-1 RORalpha1 Ik-2 HOXA5
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIGD1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIGD1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31HIGD1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P042925: view genomic region
(about GC identifiers)
Start:
|
42,923,721 bp from pter |
End:
|
42,927,848 bp from pter |
Size:
|
4,128 bases |
Orientation:
|
plus strand |
|
Proteins
for HIGD1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIG1B_HUMAN, Q9P298 (See
protein sequence)Recommended Name: HIG1 domain family member 1B Size: 99 amino acids; 11058 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
1 PDB 3D structure from  and Proteopedia  for HIGD1B:2LON (3D)
Secondary accessions: D3DX57 Q9P297Explore the universe of human proteins at neXtProt for HIGD1B: NX_Q9P298
HIGD1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258809.1 NP_057522.1
ENSEMBL proteins: ENSP00000468511 ENSP00000253410 ENSP00000464703 ENSP00000465657
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
HIGD1B for ontologies About GeneDecksing
HIGD1B Antibody Products:
Assay Products for HIGD1B: |
Protein
Domains /
Families
for HIGD1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIGD1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P298ProtoNet protein and cluster: Q9P298 UniProtKB/Swiss-Prot: HIG1B_HUMAN, Q9P298Similarity: Contains 1 HIG1 domain |
Function
for HIGD1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HIGD1B (NM_016438) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIGD1B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIGD1B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIGD1B |
|
Pathways & Interactions
for HIGD1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIGD1B
3 Interacting proteins for HIGD1B (Q9P2982, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for HIGD1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HIGD1B
Search CenterWatch for drugs/clinical trials and news about HIGD1B / HIG1B
|
Transcripts
for HIGD1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIGD1B gene (2 alternative transcripts): NM_001271880.1 NM_016438.3 Unigene Cluster for HIGD1B: HIG1 hypoxia inducible domain family, member 1B Hs.287963 [show with all ESTs]Unigene Representative Sequence: BG5734925 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591513 ENST00000590423 ENST00000253410(uc002ihm.3) ENST00000587021
ENST00000586911
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HIGD1B (NM_016438) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIGD1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIGD1B |
Additional cDNA sequence: AB038021.1 AB038022.1 BC020667.1 NR_073504.1 7 DOTS entries: DT.95173168 DT.97837462 DT.91756214 DT.95211553 DT.121000908 DT.100825646 DT.91986452 24/49 AceView cDNA sequences (see all 49): AI185719 BQ581678 CK822679 NM_016438 AI089011 BI711221 BM509921 BQ017345 AI202083 BC020667 AI186316 BE465413 AA903783 BM503772 AB038021 AI126767 AI650403 AI140020 AA040588 AI700585 BX502825 AW207459 AV708469 BF439790
GeneLoc Exon Structure
|
Expression
for HIGD1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIGD1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAGGTGCTG
About this image
See HIGD1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIGD1B
SOURCE GeneReport for Unigene cluster: Hs.287963
SABiosciences Custom PCR Arrays for HIGD1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIGD1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIGD1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIGD1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIGD1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIGD1B |
Orthologs
for HIGD1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for HIGD1B gene from 3/12 species (see all 12) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
HIGD1B6 |
-- |
61(a) |
1 ↔ 1 |
6(64295621-64298521) |
zebrafish
(Danio rerio) |
Actinopterygii |
hig16 |
hypoxia induced gene 1 |
42(a) |
1 → many |
2(1970655-1975857) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG118256 |
-- |
23(a) |
1 → many |
2R(6307919-6309196) |
ENSEMBL Gene Tree for HIGD1B (if available)
TreeFam Gene Tree for HIGD1B (if available) |
Paralogs
for HIGD1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIGD1B gene
- HIGD1A2 HIGD1C2
4 SIMAP similar genes for HIGD1B using alignment to 3 protein entries: HIG1B_HUMAN (see all proteins):HIGD1C HIGD1A HIGD2B HIGD2A
HIGD1B for paralogs About GeneDecksing
|
Genomic Variants
for HIGD1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIGD1B (42923721 - 42927848 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HIGD1B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIGD1B |
|
Disorders
/ Diseases
for HIGD1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIGD1B for disorders About GeneDecksing
1  disease for HIGD1B: About MalaCardshypoxia
Export disorders for HIGD1B gene to outside databases
|
Publications
for HIGD1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIGD1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with HIGD1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Facile backbone structure determination of human membrane proteins by NMR spectroscopy. (PubMed id 22609626)2 Klammt C.... Choe S. (2012)
- Analysis of differential gene expression in plurihormo nal pituitary adenomas using bead-based fiber-optic arrays. (PubMed id 22588334)1 Jiang Z....Zhang Y. (2012)
- Analysis of differential gene expression by bead-based fiber-optic array in nonfunctioning pituitary adenomas. (PubMed id 21351040)1 Jiang Z....Zhang Y. (2011)
- Differential gene expression by fiber-optic beadarray and pathway in adrenocorticotrophin-secreting pituitary adenomas. (PubMed id 22166531)1 Jiang Z.Q....Zhang Y.Z. (2010)
- Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas. (PubMed id 22993617)1 Jiang Z....Zhang Y. (2010)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
|
External Searches for HIGD1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIGD1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIGD1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIGD1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HIGD1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HIGD1B gene:
Search GeneIP for patents involving HIGD1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HIGD1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HIGD1B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIGD1B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIGD1B | | | OriGene Protein Over-expression Lysate for HIGD1B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIGD1B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIGD1B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIGD1B | | OriGene Custom Protein Services for HIGD1B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIGD1B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIGD1B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIGD1B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIGD1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIGD1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIGD1B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for HIGD1B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | HIGD1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIGD1B |
|  |  |  | | | | Search ThermoFisher Antibodies for HIGD1B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIGD1B |
|
|
|
|
