Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIF3A Gene

protein-coding   GIFtS: 55
GCID: GC19P046800

Hypoxia Inducible Factor 3, Alpha Subunit

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hypoxia Inducible Factor 3, Alpha Subunit1 2     PASD72 3
IPAS2 3 5     bHLHe172 3
Basic-Helix-Loop-Helix-PAS Protein MOP72 3     PAS Domain-Containing Protein 72 3
Class E Basic Helix-Loop-Helix Protein 172 3     HIF-3A2
Inhibitory PAS Domain Protein2 3     Hypoxia-Inducible Factor 3-Alpha2
Member Of PAS Protein 72 3     BHLHE173
HIF3-alpha-12 3     HIF-3-alpha3
MOP72 3     HIF3-alpha3

External Ids:    HGNC: 158251   Entrez Gene: 643442   Ensembl: ENSG000001244407   OMIM: 6099765   UniProtKB: Q9Y2N73   

Export aliases for HIF3A gene to outside databases

Previous GC identifers: GC19P047444 GC19P047191 GC19P051476 GC19P051492 GC19P043228


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HIF3A Gene:
The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric
transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit
lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is
thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression.
Multiple alternatively spliced transcript variants have been found for this gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for HIF3A Gene: 
HIF3A (hypoxia inducible factor 3, alpha subunit) is a protein-coding gene. Diseases associated with HIF3A include extratemporal epilepsy, and hypoxia, and among its related super-pathways are Cellular response to hypoxia. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ARNT2.

UniProtKB/Swiss-Prot: HIF3A_HUMAN, Q9Y2N7
Function: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1.
Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The
complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative
function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to
hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of
isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of
isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of
hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an
inhibitor of angiogenesis in the cornea (By similarity)

Gene Wiki entry for HIF3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIF3A gene promoter:
         SREBP-1a   Tal-1beta   SREBP-1b   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): HIF3A promoter sequence
   Search SABiosciences Chromatin IP Primers for HIF3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIF3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13

HIF3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIF3A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P046800:  view genomic region     (about GC identifiers)

Start:
46,800,303 bp from pter      End:
46,846,690 bp from pter
Size:
46,388 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HIF3A_HUMAN, Q9Y2N7 (See protein sequence)
Recommended Name: Hypoxia-inducible factor 3-alpha  
Size: 669 amino acids; 72433 Da
Subunit: Heterodimerizes with ARNT. Interacts via the oxygen-dependent degradation domain (ODD) with the beta
domain of VHL
Subcellular location: Nucleus. Cytoplasm. Note=In the nuclei of all periportal and perivenous hepatocytes. In the
distal perivenous zone, detected in the cytoplasm of the hepatocytes (By similarity)
Secondary accessions: B0M185 B4DNA2 Q58A43 Q66K72 Q8WXA1 Q96K34 Q9H7Z9 Q9HAI2
Alternative splicing: 7 isoforms:  Q9Y2N7-1   Q9Y2N7-2   Q9Y2N7-3   Q9Y2N7-4   Q9Y2N7-5   Q9Y2N7-6   Q9Y2N7-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HIF3A: NX_Q9Y2N7

Explore proteomics data for HIF3A at MOPED 

Post-translational modifications:

  • UniProtKB: In normoxia, hydroxylated on Pro-492 in the oxygen-dependent degradation domain (ODD) by PHD. The hydroxylated
    proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2N7

  • HIF3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HIF3A Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_071907.4  NP_690007.1  NP_690008.2  NP_690009.1  

    ENSEMBL proteins: 
     ENSP00000432809   ENSP00000366898   ENSP00000244303   ENSP00000435532   ENSP00000435200  
     ENSP00000434653   ENSP00000432613   ENSP00000300862   ENSP00000469031   ENSP00000471560  
     ENSP00000434700   ENSP00000407771   ENSP00000341877  
    Reactome Protein details: Q9Y2N7
    Human Recombinant Protein Products for HIF3A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HIF3A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HIF3A
    GenScript Custom Purified and Recombinant Proteins Services for HIF3A
    Novus Biologicals HIF3A Protein
    Novus Biologicals HIF3A Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IDA--

    HIF3A for ontologies           About GeneDecksing



    HIF3A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HIF3A
    OriGene Custom Antibody Services for HIF3A
    GenScript Custom Superior Antibodies Services for HIF3A
    Novus Biologicals HIF3A Antibodies
    Abcam antibodies for HIF3A
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for HIF3A
    LSBio Antibodies in human, mouse, rat for HIF3A 

    Assay Products for HIF3A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIF3A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIF3A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bHLH: Basic helix-loop-helix proteins

    5/6 InterPro protein domains (see all 6):
     IPR013655 PAS_fold_3
     IPR021537 HIF_alpha_subunit
     IPR001610 PAC
     IPR013767 PAS_fold
     IPR000014 PAS

    Graphical View of Domain Structure for InterPro Entry Q9Y2N7

    ProtoNet protein and cluster: Q9Y2N7

    5 Blocks protein domains:
    IPB000014 PAS domain
    IPB001067 Nuclear translocator signature
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001610 PAC motif
    IPB013655 PAS fold-3


    UniProtKB/Swiss-Prot: HIF3A_HUMAN, Q9Y2N7
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    HIF3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HIF3A_HUMAN, Q9Y2N7
    Function: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1.
    Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The
    complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative
    function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to
    hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of
    isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of
    isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of
    hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an
    inhibitor of angiogenesis in the cornea (By similarity)
    Induction: Strongly induced by hypoxia (1% O(2)), both at the level of protein and mRNA due to an increase in
    protein stability and transcriptional activation

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0004871signal transducer activity IEA--
    GO:0005515protein binding ----
    GO:0046983protein dimerization activity IEA--
         
    HIF3A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HIF3A:
     Increased cell number in G2M,   Synthetic lethal with imatinib 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hif3a):
     cardiovascular system  muscle  respiratory system 

    HIF3A for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HIF3A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIF3A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIF3A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIF3A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIF3A
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate HIF3A (see all 48):
    hsa-miR-100* hsa-let-7d hsa-miR-29a hsa-miR-765 hsa-miR-3916 hsa-miR-570 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): HIF3A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIF3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIF3A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIF3A
    Sirion Biotech Customized adenovirus for overexpression of HIF3A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HIF3A (see all 18)
    OriGene ORF clones in mouse, rat for HIF3A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HIF3A (NM_152794)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIF3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIF3A
    Sirion Biotech Customized lentivirus for stable overexpression of HIF3A 
                         Customized lentivirus expression plasmids for stable overexpression of HIF3A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIF3A
    Search LifeMap BioReagents cell lines for HIF3A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF3A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for HIF3A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cellular response to hypoxia
    Cellular response to hypoxia0.72
    Cellular responses to stress0.72
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen0.72
    Regulation of Gene Expression by Hypoxia-inducible Factor0.36
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha0.72
    2Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HIF3A
        Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

    5        Reactome Pathways for HIF3A
        Cellular response to hypoxia
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Regulation of Gene Expression by Hypoxia-inducible Factor
    Cellular responses to stress



    HIF3A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIF3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for HIF3A (Q9Y2N73 ENSP000003668984) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGLN3Q9H6Z93, ENSP000002504574I2D: score=1 STRING: ENSP00000250457
    ARNTP275403, ENSP000003514074I2D: score=1 STRING: ENSP00000351407
    HIF1AQ166653, ENSP000003380184I2D: score=2 STRING: ENSP00000338018
    VHLP403373, ENSP000002564744I2D: score=2 STRING: ENSP00000256474
    EGLN1Q9GZT93, ENSP000003556014I2D: score=1 STRING: ENSP00000355601
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter IEA--
    GO:0007165signal transduction ----
    GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS--

    HIF3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIF3A

    Search CenterWatch for drugs/clinical trials and news about HIF3A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIF3A gene (4 alternative transcripts): 
    NM_022462.4  NM_152794.3  NM_152795.3  NM_152796.2  

    Unigene Cluster for HIF3A:

    Hypoxia inducible factor 3, alpha subunit
    Hs.420830  [show with all ESTs]
    Unigene Representative Sequence: NM_152794
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000533789 ENST00000475432(uc002pef.2) ENST00000244302(uc002peg.4)
    ENST00000377670 ENST00000524533 ENST00000244303 ENST00000528563 ENST00000533145
    ENST00000472815(uc002pej.2) ENST00000526506 ENST00000291300 ENST00000300862
    ENST00000600879 ENST00000600383 ENST00000525854 ENST00000529205 ENST00000531043
    ENST00000600236
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIF3A
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate HIF3A (see all 48):
    hsa-miR-100* hsa-let-7d hsa-miR-29a hsa-miR-765 hsa-miR-3916 hsa-miR-570 hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): HIF3A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HIF3A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIF3A
    Clone
    Products:
         
    OriGene clones in human, mouse for HIF3A (see all 18)
    OriGene ORF clones in mouse, rat for HIF3A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): HIF3A (NM_152794)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIF3A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIF3A
    Sirion Biotech Customized lentivirus for stable overexpression of HIF3A 
                         Customized lentivirus expression plasmids for stable overexpression of HIF3A 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HIF3A
    OriGene qSTAR qPCR primer pairs in human, mouse for HIF3A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIF3A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIF3A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIF3A

    Additional mRNA sequence: 

    AB054067.1 AB118749.1 AB295039.1 AF079154.1 AK021421.1 AK021737.1 AK021881.1 AK297828.1 
    AK299699.1 AK314680.1 BC080551.1 

    14 DOTS entries:

    DT.87014382  DT.312390  DT.91692863  DT.91692865  DT.91692857  DT.40296756  DT.95371242  DT.98083597 
    DT.40316103  DT.428442  DT.95257936  DT.92064013  DT.95371241  DT.121444344 

    24/142 AceView cDNA sequences (see all 142):

    BU678311 AA359276 F06283 AW270837 NM_152796 AA428211 BM722881 AF079154 
    CR612598 BQ684757 AI075316 F05192 AI091960 NM_152794 BM972872 AA346560 
    BU742834 AB054067 Z39179 CA438713 BQ416614 BM677920 NM_152795 NM_022462 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for HIF3A (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:                    -           -     -     -                                                                       -                                   -   
    SP2:                                -     -     -                                                                       -                                   -   
    SP3:              -     -           -     -     -                                                                       -                                       
    SP4:                    -           -     -     -     -                                                                 -                       -     -     -   
    SP5:              -     -           -     -     -                                                                                                               

    ExUns: 17a · 17b · 17c ^ 18 ^ 19
    SP1:                              
    SP2:                    -         
    SP3:                              
    SP4:  -                           
    SP5:                              


    ECgene alternative splicing isoforms for HIF3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIF3A expression in normal human tissues (normalized intensities)      HIF3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGGCACG
    HIF3A Expression
    About this image


    HIF3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e12.5   
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Intestine (Gastrointestinal Tract)
             neonatal small intestine   
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose

    See HIF3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIF3A

    SOURCE GeneReport for Unigene cluster: Hs.420830

    UniProtKB/Swiss-Prot: HIF3A_HUMAN, Q9Y2N7
    Tissue specificity: Expressed in kidney. Expressed abundantly in lung epithelial cells. Expression is regulated in
    an oxygen-dependent manner

        SABiosciences Expression via Pathway-Focused PCR Array including HIF3A: 
              Hypoxia Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HIF3A
    OriGene qSTAR qPCR primer pairs in human, mouse for HIF3A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIF3A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIF3A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIF3A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HIF3A gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hif3a1 , 5 hypoxia inducible factor 3, alpha subunit1, 5 84.39(n)1
    83.23(a)1
      7 (9.15 cM)5
    534171  NM_001162950.11  NP_001156422.11 
     170315075 
    lizard
    (Anolis carolinensis)
    Reptilia HIF3A6
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343568.1(194964-233742)
    zebrafish
    (Danio rerio)
    Actinopterygii hif1al1 hypoxia-inducible factor 1, alpha subunit, like 57.5(n)
    50.72(a)
      393376  NM_200405.1  NP_956699.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hlh-346
    Helix-loop-helix 34
    24(a)
    possible ortholog
    V(13705975-13707360)


    ENSEMBL Gene Tree for HIF3A (if available)
    TreeFam Gene Tree for HIF3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIF3A gene
    ARNT22  CLOCK2  NPAS22  ARNT2  EPAS12  NPAS32  HIF1A2  SIM22  
    SIM12  ARNTL2  NPAS12  ARNTL22  
    8 SIMAP similar genes for HIF3A using alignment to 11 protein entries:     HIF3A_HUMAN (see all proteins):
    HIF-1A    EPAS1    HIF1A    CLOCK    NPAS2    NPAS3
    NPAS4    AHRR

    HIF3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1240 SNPs in HIF3A are shown (see all 1240)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164789281,2
    C,Funtested143243882(+) TTTCTC/TTCCCC 4 -- int11Minor allele frequency- T:0.02EU 385
    rs1422482331,2
    C,Funtested143260765(+) TGCTCG/AGAGCT 7 /Q /R mis1 int11Minor allele frequency- A:0.00NA 4518
    rs1912097981,2
    --43226306(+) GGCTGA/GAGTGC 1 -- us2k10--------
    rs1389972931,2
    C--43226408(+) TGTGCC/TACCAC 1 -- us2k10--------
    rs1139494441,2
    C,F--43226550(+) CCATGG/ACCGGC 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1459470151,2
    C--43226593(+) ACATCC/TCACCT 1 -- us2k10--------
    rs1169765201,2
    F--43226624(+) AAGCTG/AATTTC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1481921281,2
    --43226675(+) TCAAAC/TGAATC 1 -- us2k10--------
    rs745852951,2
    C--43226699(+) AATAAG/-GCAAT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1154282751,2
    F--43226722(+) AATATT/CTGACA 1 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for HIF3A (46800303 - 46846690 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for HIF3A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718653CNV Deletion23290073
    esv2661691CNV Deletion23128226
    esv2573837CNV Deletion19546169

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HIF3A
    DNA2.0 Custom Variant and Variant Library Synthesis for HIF3A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609976    OMIM disorders: --

    4 diseases for HIF3A:    About MalaCards
    extratemporal epilepsy    hypoxia    shigellosis    renal cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for HIF3A:
    Extratemporal epilepsy

    HIF3A for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: HIF3A (1 document)

    Export disorders for HIF3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIF3A gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with HIF3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and characterization of hypoxia-inducible factor (HIF)- 3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha. (PubMed id 11573933)1, 2, 3 Hara S.... Imura N. (2001)
    2. Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex. (PubMed id 12538644)1, 2, 9 Maynard M.A.... Ohh M. (2003)
    3. Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF- 1alpha. (PubMed id 16775626)1, 2 Li Q.F.... Lin H. (2006)
    4. Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma. (PubMed id 16126907)1, 2 Maynard M.A.... Ohh M. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. (PubMed id 11734856)1, 3 Makino Y....Poellinger L. (2001)
    7. Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins. (PubMed id 16182248)1, 9 Jang M.S....Cho S. (2005)
    8. Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression. (PubMed id 17998805)1, 9 Maynard M.A....Ohh M. (2007)
    9. A hypoxia-inducible factor (HIF)-3a splicing variant, HIF-3a4 impairs angiogenesis in hypervascular malignant meningiomas with epigene tically silenced HIF-3a4. (PubMed id 23485455)1 Ando H....Wakabayashi T. (2013)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64344 HGNC: 15825 AceView: HIF3A Ensembl:ENSG00000124440 euGenes: HUgn64344
    ECgene: HIF3A H-InvDB: HIF3A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIF3A Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Hypoxia_inducible_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIF3A gene:
    Search GeneIP for patents involving HIF3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HIF3A   OriGene RNAi products in human, mouse, rat for HIF3A  
     OriGene qPCR primer pairs and template standards for HIF3A   OriGene Protein Over-expression Lysate for HIF3A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HIF3A  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIF3A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HIF3A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIF3A   OriGene Custom Protein Services for HIF3A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIF3A
     QIAGEN SeqTarget long-range PCR primers for resequencing HIF3A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIF3A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIF3A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIF3A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIF3A
     GenScript Custom Purified and Recombinant Proteins Services for HIF3A GenScript cDNA clones with any tag delivered in your preferred vector for HIF3A
     GenScript Custom Assay Services for HIF3A GenScript Custom Superior Antibodies Services for HIF3A
     GenScript Custom overexpressing Cell Line Services for HIF3A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HIF3A promoter
     Search Chromatin IP Primers for HIF3A
     RT2 qPCR Primer Assay in human, mouse, rat HIF3A
     GNC Network for HIF3A
     SABiosciences PCR Arrays including human, mouse, rat HIF3A
     Search Tocris compounds for HIF3A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HIF3A antibodies
     HIF3A proteins
     HIF3A lysates
     Antibodies for HIF3A
     See all of Abcam's Antibodies, Kits and Proteins for HIF3A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for HIF3A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF3A
     SwitchGear 3'UTR luciferase reporter plasmids for HIF3A
     SwitchGear Promoter luciferase reporter plasmids for HIF3A
     ThermoFisher Antibodies for HIF3A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIF3A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HIF3A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HIF3A
    Customized:
     lentivirus for stable overexpression of HIF3A
     lentivirus expression plasmids for stable overexpression of HIF3A
     adenovirus for overexpression of HIF3A
     LSBio Antibodies in human, mouse, rat for HIF3A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIF3A gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4