Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HIF1AN Gene

protein-coding   GIFtS: 64
GCID: GC10P102285

Hypoxia Inducible Factor 1, Alpha Subunit Inhibitor

  See HIF1AN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Hypoxia Inducible Factor 1, Alpha Subunit Inhibitor1 2     FIH-12 3
FIH12 3 5     Factor Inhibiting HIF12
Peptide-Aspartate Beta-Dioxygenase1 2     Hypoxia-Inducible Factor 1-Alpha Inhibitor2
Factor Inhibiting HIF-12 3     EC 1.14.11.303
Hypoxia-Inducible Factor Asparagine Hydroxylase2 3     EC 1.14.11.n43

External Ids:    HGNC: 171131   Entrez Gene: 556622   Ensembl: ENSG000001661357   OMIM: 6066155   UniProtKB: Q9NWT63   

Export aliases for HIF1AN gene to outside databases

Previous GC identifers: GC10P101188 GC10P101529 GC10P102420 GC10P101960 GC10P095924


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for HIF1AN Gene:
HIF1AN (hypoxia inducible factor 1, alpha subunit inhibitor) is a protein-coding gene. Diseases associated with HIF1AN include hypoxia, and pancreatic endocrine tumors. GO annotations related to this gene include protein homodimerization activity and NF-kappaB binding. An important paralog of this gene is TYW5.

UniProtKB/Swiss-Prot: HIF1N_HUMAN, Q9NWT6
Function: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an
oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with
transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional
repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues
within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing
proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively
regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting
vascular differentiation

Gene Wiki entry for HIF1AN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIF1AN gene promoter:
         SRF   RP58   SRF (504 AA)   MIF-1   CUTL1   Tal-1beta   E47   Max   IRF-7A   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIF1AN promoter sequence
   Search Chromatin IP Primers for HIF1AN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIF1AN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24

HIF1AN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIF1AN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P102285:  view genomic region     (about GC identifiers)

Start:
102,288,829 bp from pter      End:
102,319,755 bp from pter
Size:
30,927 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HIF1N_HUMAN, Q9NWT6 (See protein sequence)
Recommended Name: Hypoxia-inducible factor 1-alpha inhibitor  
Size: 349 amino acids; 40285 Da
Cofactor: Fe(2+) ion
Subunit: Homodimer; homodimerization is essential for catalytic activity. Interacts with VHL and HIF1A. Part of a
complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Interacts with NFKB1 and NFKBIA. Interacts with NOTCH1,
NOTCH2 and NOTCH3 but not with NOTCH4. Interacts with APBA3; binding inhibits HIF1AN binding to HIF1A. Interacts
with TNKS2. Interacts with PPP1R12A. Interacts with ASB4 (By similarity). Interacts with UBE3A
Mass spectrometry: Mass=40566; Method=Electrospray; Range=1-349; Source=PubMed:15239670;
Selected PDB 3D structures from and Proteopedia for HIF1AN (see all 28):
1H2K (3D)        1H2L (3D)        1H2M (3D)        1H2N (3D)        1IZ3 (3D)        1MZE (3D)    
Secondary accessions: D3DR69 Q5W147 Q969Q7 Q9NPV5

Explore the universe of human proteins at neXtProt for HIF1AN: NX_Q9NWT6

Explore proteomics data for HIF1AN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115, Lys131
  • Modification sites at PhosphoSitePlus

  • See HIF1AN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060372.2  
    ENSEMBL proteins: 
     ENSP00000433360   ENSP00000299163   ENSP00000432791  
    Reactome Protein details: Q9NWT6

    HIF1AN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HIF1AN
    OriGene Protein Over-expression Lysate for HIF1AN
    OriGene MassSpec for HIF1AN
    OriGene Custom Protein Services for HIF1AN
    GenScript Custom Purified and Recombinant Proteins Services for HIF1AN
    Novus Biologicals HIF1AN Proteins
    Novus Biologicals HIF1AN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HIF1AN
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HIF1AN 

     
    antibodies-online proteins for HIF1AN (14 products) 

     
    antibodies-online peptides for HIF1AN

    HIF1AN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIF1AN
    R&D Systems Antibodies for HIF1AN (FIH-1/HIF-1AN)
    Cell Signaling Technology (CST) Antibodies for HIF1AN 
    OriGene Antibodies for HIF1AN
    OriGene Custom Antibody Services for HIF1AN
    Novus Biologicals HIF1AN Antibodies
    Abcam antibodies for HIF1AN (Q9NWT6, Q5W147)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HIF1AN
    antibodies-online antibodies for HIF1AN (87 products) 

    HIF1AN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIF1AN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIF1AN
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HIF1AN 
    antibodies-online kits for HIF1AN (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR003347 JmjC_dom
     IPR027452 FIH-1_domII

    Graphical View of Domain Structure for InterPro Entry Q9NWT6

    ProtoNet protein and cluster: Q9NWT6

    UniProtKB/Swiss-Prot: HIF1N_HUMAN, Q9NWT6
    Similarity: Contains 1 JmjC domain


    Find genes that share domains with HIF1AN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HIF1N_HUMAN, Q9NWT6
    Function: Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an
    oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with
    transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional
    repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues
    within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing
    proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively
    regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting
    vascular differentiation
    Catalytic activity: Hypoxia-inducible factor-L-asparagine + 2-oxoglutarate + O(2) = hypoxia-inducible
    factor-(3S)-3-hydroxy-L-asparagine + succinate + CO(2)
    Catalytic activity: Ankyrin-repeat-L-histidine + 2-oxoglutarate + O(2) = ankyrin-repeat-(3S)-3-hydroxy-L-histidine
    + succinate + CO(2)
    Biophysicochemical properties: Kinetic parameters: KM=100 uM for HIF1A (788-822) peptide; KM=160 uM for HIF2A
    (832-866) peptide; KM=0.5 uM for Fe(2+); KM=25 uM for 2-oxoglutarate; KM=260 uM for ascorbate; KM=90 uM for O(2);
    Note=The kinetic constants are determined for the recombinant FLAG-His-tagged protein;

         Enzyme Numbers (IUBMB): EC 1.14.11.n41 EC 1.14.11.301

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005112Notch binding IPI17573339
    GO:0005506iron ion binding IDA12446723
    GO:0005515protein binding IPI11641274
    GO:0008270zinc ion binding IDA12446723
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors EXP--
         
    Find genes that share ontologies with HIF1AN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HIF1AN:
     Increased circadian period len 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hif1an):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  growth/size/body 
     homeostasis/metabolism  liver/biliary system  muscle  normal  respiratory system 

    Find genes that share phenotypes with HIF1AN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hif1antm1.2Rsjo for HIF1AN

       genOway: Develop your customized and physiologically relevant rodent model for HIF1AN

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIF1AN:
    hsa-mir-296-3p (MIRT038515), hsa-mir-148b-3p (MIRT019390), hsa-mir-193b-3p (MIRT041433), hsa-mir-31-5p (MIRT006468), hsa-let-7e-5p (MIRT051688), hsa-mir-1301-3p (MIRT036066), hsa-mir-19b-3p (MIRT031231), hsa-mir-328-3p (MIRT043794), hsa-mir-23b-3p (MIRT046339), hsa-mir-130b-3p (MIRT020305)

    Block miRNA regulation of human, mouse, rat HIF1AN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIF1AN (see all 158):
    hsa-miR-520f hsa-miR-3921 hsa-miR-519a hsa-miR-877* hsa-miR-3622b-3p hsa-miR-3909 hsa-miR-761 hsa-miR-520b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIF1AN
    Predesigned siRNA for gene silencing in human, mouse, rat HIF1AN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIF1AN

    Clone
    Products:
         
    OriGene clones in human, mouse for HIF1AN (see all 7)
    OriGene ORF clones in mouse, rat for HIF1AN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIF1AN (NM_017902)
    Sino Biological Human cDNA Clone for HIF1AN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIF1AN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIF1AN
    Addgene plasmids for HIF1AN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HIF1AN
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIF1AN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF1AN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HIF1N_HUMAN, Q9NWT6: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but
    interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear
    localization in macrophages
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634colocalizes with nucleus IDA18299578
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0048471perinuclear region of cytoplasm IDA19726677

    Find genes that share ontologies with HIF1AN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for HIF1AN About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen1.00
    Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha0.00
    Cellular response to hypoxia1.00
    2Cellular Senescence
    Cellular responses to stress0.81
    3Translational Control
    Translational Control
    4Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
    5HIF1Alpha Pathway
    HIF1Alpha Pathway


    Find genes that share SuperPaths with HIF1AN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HIF1AN
        HIF1Alpha Pathway

    2 Cell Signaling Technology (CST) Pathways for HIF1AN
        Translational Control
    Angiogenesis

    2 BioSystems Pathways for HIF1AN
        HIF-2-alpha transcription factor network
    Hypoxic and oxygen homeostasis regulation of HIF-1-alpha


    1 Reactome Pathway for HIF1AN
        Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha


        Pathway & Disease-focused RT2 Profiler PCR Array including HIF1AN: 
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HIF1AN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for HIF1AN (Q9NWT61, 2, 3 ENSP000002991634) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNKS2Q9H2K21, 2, 3, ENSP000003606894EBI-745632,EBI-4398527 MINT-8084814 MINT-8084841 MINT-8084829 MINT-8084940 I2D: score=1 STRING: ENSP00000360689
    TNKSO952711, 2, 3, ENSP000003115794EBI-745632,EBI-1105254 MINT-8084882 MINT-8084923 I2D: score=1 STRING: ENSP00000311579
    HIF1AQ166651, 2, 3, ENSP000003380184EBI-745632,EBI-447269 MINT-6802187 I2D: score=4 STRING: ENSP00000338018
    ASB9Q96DX51, 2, 3, ENSP000003698554EBI-745632,EBI-745641 MINT-66697 I2D: score=4 STRING: ENSP00000369855
    GABPB2Q8TAK52, 3, ENSP000003579144MINT-8085095 I2D: score=1 STRING: ENSP00000357914
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0036138peptidyl-histidine hydroxylation IDA--
    GO:0042264peptidyl-aspartic acid hydroxylation IDA--
    GO:0042265peptidyl-asparagine hydroxylation IMP19245366
    GO:0045663positive regulation of myoblast differentiation IDA18299578

    Find genes that share ontologies with HIF1AN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HIF1AN
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIF1AN (HIF1N)

    5 HMDB Compounds for HIF1AN    About this table
    CompoundSynonyms CAS #PubMed Ids
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    IronArmco iron (see all 19)7439-89-6--
    Oxoglutaric acid2-Ketoglutarate (see all 9)328-50-7--
    OxygenOxygen (see all 5)7782-44-7--
    Succinic acid1,2-Ethanedicarboxylate (see all 11)110-15-6--

    2 DrugBank Compounds for HIF1AN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-(CARBOXYCARBONYL)-D-PHENYLALANINE-- --target--10592235
    D-tartaric acid(-)-Tartaric acid (see all 7)147-71-7target----

    7 Novoseek inferred chemical compound relationships for HIF1AN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha-ketoglutarate 77.2 9 16321790 (1), 15299039 (1), 20396966 (1), 12432100 (1) (see all 5)
    asparagine 76 15 18426857 (3), 16579968 (2), 14734545 (1), 12482756 (1) (see all 8)
    proline 55.4 5 16579968 (1), 20416277 (1), 16585195 (1), 18426857 (1)
    oxygen 33 12 19401150 (2), 16686428 (2), 16321790 (1), 20416277 (1) (see all 7)
    cobalt 30.6 1 16705796 (1)
    nickel 25.7 1 16705796 (1)
    nadph 14.2 2 16321790 (1), 15299039 (1)



    Find genes that share compounds with HIF1AN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HIF1AN gene: 
    NM_017902.2  

    Unigene Cluster for HIF1AN:

    Hypoxia inducible factor 1, alpha subunit inhibitor
    Hs.500788  [show with all ESTs]
    Unigene Representative Sequence: NM_017902
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533589 ENST00000299163(uc001krj.4) ENST00000526476 ENST00000528044
    ENST00000478787
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIF1AN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIF1AN (see all 158):
    hsa-miR-520f hsa-miR-3921 hsa-miR-519a hsa-miR-877* hsa-miR-3622b-3p hsa-miR-3909 hsa-miR-761 hsa-miR-520b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HIF1AN
    Predesigned siRNA for gene silencing in human, mouse, rat HIF1AN
    Clone
    Products:
         
    OriGene clones in human, mouse for HIF1AN (see all 7)
    OriGene ORF clones in mouse, rat for HIF1AN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIF1AN (NM_017902)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIF1AN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIF1AN
    Addgene plasmids for HIF1AN 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HIF1AN
    OriGene qSTAR qPCR primer pairs in human, mouse for HIF1AN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIF1AN
      QuantiTect SYBR Green Assays in human, mouse, rat HIF1AN
      QuantiFast Probe-based Assays in human, mouse, rat HIF1AN

    Additional mRNA sequence: 

    AF395830.1 AK000622.1 AK025680.1 AK295353.1 AL359615.1 BC007719.2 BC015574.2 

    13 DOTS entries:

    DT.312780  DT.100675644  DT.443730  DT.91921583  DT.95369693  DT.100777659  DT.86852947  DT.121302782 
    DT.92013790  DT.100777300  DT.100777660  DT.91934218  DT.92431319 

    Selected AceView cDNA sequences (see all 235):

    AA912210 AI828893 BM906687 BE252822 BM126975 CB142092 BM717323 BX402859 
    BM126343 CD367426 BM782366 AI140764 AA490565 AF395830 AW205129 AA496967 
    BQ718820 AI933064 AA972839 BC007719 BQ896786 BM452795 BQ424981 AA872521 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HIF1AN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCAGGAGT
    HIF1AN Expression
    About this image

    HIF1AN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIF1AN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500788
        Pathway & Disease-focused RT2 Profiler PCR Array including HIF1AN: 
              Hypoxia Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HIF1AN
    OriGene qSTAR qPCR primer pairs in human, mouse for HIF1AN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIF1AN
    QuantiTect SYBR Green Assays in human, mouse, rat HIF1AN
    QuantiFast Probe-based Assays in human, mouse, rat HIF1AN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF1AN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for HIF1AN gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hif1an1 , 5 hypoxia-inducible factor 1, alpha subunit inhibitor less1, 5 91.12(n)1
    97.13(a)1
      19 (37.98 cM)5
    3195941  NM_176958.31  NP_795932.21 
     445628505 
    chicken
    (Gallus gallus)
    Aves HIF1AN1 hypoxia inducible factor 1, alpha subunit inhibitor less 80.83(n)
    89.68(a)
      428952  XM_426507.4  XP_426507.2 
    lizard
    (Anolis carolinensis)
    Reptilia HIF1AN6
    hypoxia inducible factor 1, alpha subunit inhibito...
    86(a)
    1 ↔ 1
    GL343388.1(271368-284967)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ042402.12   -- 80.06(n)    BJ042402.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.133712 Danio rerio mRNA similar to hypoxia-inducible factor 1, alpha subunit inhibitor (cDNA clone MGC55763 IMAGE3816694), complete cds less 75.55(n)    BC044475.1 


    ENSEMBL Gene Tree for HIF1AN (if available)
    TreeFam Gene Tree for HIF1AN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HIF1AN gene
    TYW52  KDM82  HSPBAP12  

    Find genes that share paralogs with HIF1AN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HIF1AN (see all 470)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111905971,2
    C,A--102293676(+) TAATTA/TATTTA 1 -- us2k1 tfbs34Minor allele frequency- T:0.16CSA WA NA EA 359
    rs1437845791,2
    --102293677(+) AATTAA/GTTTAT 1 -- us2k10--------
    rs1930507681,2
    --102293784(+) AATCCC/TCCTAC 1 -- us2k10--------
    rs1468570281,2
    C--102293813(+) TGGGAC/GTACAG 1 -- us2k10--------
    rs746502181,2
    C,F--102293830(+) ATCAAC/TGCACC 1 -- us2k16Minor allele frequency- T:0.16NA CSA WA EA 364
    rs1830673431,2
    --102293836(+) GCACCC/GAGCTA 1 -- us2k10--------
    rs1406081911,2
    --102293878(+) TGCTAA/TGTTGC 1 -- us2k10--------
    rs115993751,2
    H--102293922(+) tcctcC/Ttgcct 1 -- us2k10--------
    rs1437311671,2
    --102293957(+) CAGGCA/GTGTGC 1 -- us2k10--------
    rs1510648691,2
    C--102294091(+) TAGTCC/TGGCAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIF1AN (102288829 - 102319755 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HIF1AN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7519CNV Insertion18451855
    dgv811n71CNV Loss21882294
    nsv831963CNV Loss17160897
    nsv831962CNV Gain17160897
    nsv895957CNV Gain21882294
    essv24916CNV CNV17122850

    Human Gene Mutation Database (HGMD): HIF1AN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIF1AN
    DNA2.0 Custom Variant and Variant Library Synthesis for HIF1AN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606615    OMIM disorders: --

    3 diseases for HIF1AN:    
    About MalaCards
    hypoxia    pancreatic endocrine tumors    pre-eclampsia


    Find genes that share disorders with HIF1AN           About GenesLikeMe

    2 Novoseek inferred disease relationships for HIF1AN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma renal cell 36.1 1 15220362 (1)
    tumors 7.78 1 17089387 (1)

    Genetic Association Database (GAD): HIF1AN
    Human Genome Epidemiology (HuGE) Navigator: HIF1AN (8 documents)

    Export disorders for HIF1AN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HIF1AN gene, integrated from 10 sources (see all 105):
    (articles sorted by number of sources associating them with HIF1AN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. (PubMed id 11641274)1, 2, 3, 9 Mahon P.C.... Semenza G.L. (Genes Dev. 2001)
    2. Mint3 enhances the activity of hypoxia-inducible factor-1 (HIF-1) in macrophages by suppressing the activity of factor inhibiting HIF-1. (PubMed id 19726677)1, 2, 9 Sakamoto T. and Seiki M. (J. Biol. Chem. 2009)
    3. Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. (PubMed id 12482756)1, 2, 9 Lee C.... Ryu S.E. (J. Biol. Chem. 2003)
    4. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. (PubMed id 18299578)1, 2, 9 Zheng X.... Poellinger L. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor. (PubMed id 14734545)1, 2, 9 Linke S....Peet D.J. (J. Biol. Chem. 2004)
    6. Structure of factor-inhibiting hypoxia-inducible factor 1: an asparaginyl hydroxylase involved in the hypoxic response pathway. (PubMed id 12432100)1, 2, 9 Dann C.E. III... Deisenhofer J. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. (PubMed id 22645313)1, 2 Martinez-Noel G.... Howley P.M. (Mol. Cell. Biol. 2012)
    8. Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. (PubMed id 21177872)1, 2 Yang M.... Schofield C.J. (J. Biol. Chem. 2011)
    9. Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post- translational hydroxylation of histidinyl residues within ankyrin repeat domains. (PubMed id 21251231)1, 2 Yang M....Schofield C.J. (FEBS J. 2011)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55662 HGNC: 17113 AceView: HIF1AN Ensembl:ENSG00000166135 euGenes: HUgn55662
    ECgene: HIF1AN H-InvDB: HIF1AN

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HIF1AN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HIF1AN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HIF1AN gene:
    Search GeneIP for patents involving HIF1AN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of HIF1AN
     
     EMD Millipore genomic analysis products

      
     Antibodies for HIF1AN (FIH-1/HIF-1AN)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HIF1AN   OriGene RNAi products in human, mouse, rat for HIF1AN  
     OriGene qPCR primer pairs and template standards for HIF1AN   OriGene Protein Over-expression Lysate for HIF1AN  
     OriGene MassSpec for HIF1AN   OriGene clones in human, mouse for HIF1AN  
     OriGene qSTAR qPCR primer pairs in human, mouse for HIF1AN   OriGene Purified Protein for HIF1AN  
     OriGene ORF clones in mouse, rat for HIF1AN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HIF1AN   OriGene Custom Protein Services for HIF1AN  

     
     
     Block miRNA regulation of human, mouse, rat HIF1AN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIF1AN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIF1AN Predesigned siRNA for gene silencing in human, mouse, rat HIF1AN
     QuantiFast Probe-based Assays in human, mouse, rat HIF1AN QuantiTect SYBR Green Assays in human, mouse, rat HIF1AN
     PCR Arrays including human, mouse, rat HIF1AN Search Chromatin IP Primers for HIF1AN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIF1AN  GeneGlobe Interaction Network for HIF1AN
     Regulatory tfbs in HIF1AN promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIF1AN GenScript cDNA clones with any tag delivered in your preferred vector for HIF1AN
     GenScript Custom Assay Services for HIF1AN GenScript Custom overexpressing Cell Line Services for HIF1AN
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for HIF1AN 

     Search Tocris compounds for HIF1AN (HIF1N)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for HIF1AN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Drugs for HIF1AN
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HIF1AN antibodies
     HIF1AN proteins
     HIF1AN lysates
     Antibodies for HIF1AN
     See all of Abcam's Antibodies, Kits and Proteins for HIF1AN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HIF1AN
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIF1AN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF1AN
     Browse SwitchGear 3'UTR luciferase reporter plasmids for HIF1AN
     SwitchGear Promoter luciferase reporter plasmids for HIF1AN
     ThermoFisher Antibody for HIF1AN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIF1AN
     Browse compounds at ApexBio
     Addgene plasmids for HIF1AN
      Search eBioscience for proteins for HIF1AN
      Search eBioscience for elisas for HIF1AN
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for HIF1AN
     antibodies-online antibodies for HIF1AN (87 products)
     antibodies-online kits for HIF1AN (4 products)
     antibodies-online peptides for HIF1AN
     antibodies-online proteins for HIF1AN (14 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HIF1AN gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4