Aliases for HIF1AN Gene
External Ids for HIF1AN Gene
Previous GeneCards Identifiers for HIF1AN Gene
GeneCards Summary for HIF1AN Gene
HIF1AN (Hypoxia Inducible Factor 1, Alpha Subunit Inhibitor) is a Protein Coding gene. Diseases associated with HIF1AN include hypoxia. Among its related pathways are Angiogenesis (CST) and Cellular Senescence. GO annotations related to this gene include protein homodimerization activity and NF-kappaB binding. An important paralog of this gene is HSPBAP1.
UniProtKB/Swiss-Prot for HIF1AN Gene
Hydroxylates HIF-1 alpha at Asp-803 in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.