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HIF1A Gene

protein-coding   GIFtS: 74
GCID: GC14P062162

Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix...

  See HIF1A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix
Transcription Factor)1 2
     HIF-1alpha2
MOP12 3 5     HIF12
Basic-Helix-Loop-Helix-PAS Protein MOP12 3     HIF1-ALPHA2
Class E Basic Helix-Loop-Helix Protein 782 3     ARNT Interacting Protein2
Member Of PAS Protein 12 3     Hypoxia-Inducible Factor 1 Alpha Isoform I.32
HIF-1-alpha2 3     Hypoxia-Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix
Transcription Factor)2
PASD82 3     Hypoxia-Inducible Factor 1-Alpha2
ARNT-Interacting Protein2 3     Hypoxia-Inducible Factor1alpha2
bHLHe782 3     Member Of PAS Superfamily 12
PAS Domain-Containing Protein 82 3     BHLHE783
HIF-1A2     HIF1-alpha3

External Ids:    HGNC: 49101   Entrez Gene: 30912   Ensembl: ENSG000001006447   OMIM: 6033485   UniProtKB: Q166653   

Export aliases for HIF1A gene to outside databases

Previous GC identifers: GC14P059488 GC14P055956 GC14P060152 GC14P061231 GC14P042326


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIF1A Gene:
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a
heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and
systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in
energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or
facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization,
tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding
different isoforms have been identified for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for HIF1A Gene:
HIF1A (hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)) is a protein-coding gene. Diseases associated with HIF1A include supraglottic laryngeal cancer, and breast fibroadenoma. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ARNT2.

UniProtKB/Swiss-Prot: HIF1A_HUMAN, Q16665
Function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic
conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters,
glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase
oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic
vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence
5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires
recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with
both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates
activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons
during hypoxia

summary for HIF1A Gene:
Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased
oxygen availability in the cellular environment. They influence cell metabolism, cell survival and
angiogenesis to maintain biological homeostasis. The HIF family is made up of alpha subunits (HIF-1, HIF-2
and HIF-3) and a constitutively expressed beta subunit (ARNT; also known as Aryl hydrocarbon Receptor
Nuclear Translocator).

Gene Wiki entry for HIF1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIF1A gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIF1A promoter sequence
   Search Chromatin IP Primers for HIF1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIF1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.2   Ensembl cytogenetic band:  14q23.2   HGNC cytogenetic band: 14q23.2

HIF1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIF1A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P062162:  view genomic region     (about GC identifiers)

Start:
62,162,119 bp from pter      End:
62,214,977 bp from pter
Size:
52,859 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HIF1A_HUMAN, Q16665 (See protein sequence)
Recommended Name: Hypoxia-inducible factor 1-alpha  
Size: 826 amino acids; 92670 Da
Subunit: Interacts with the HIF1A beta/ARNT subunit; heterodimerization is required for DNA binding. Interacts
with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (By
similarity). Interacts with EP300 (via TAZ-type 1 domains); the interaction is stimulated in response to hypoxia
and inhibited by CITED2. Interacts with CREBBP (via TAZ-type 1 domains). Interacts with NCOA1, NCOA2, APEX and
HSP90. Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to
polyubiquitination and subsequent HIF1A proteasomal degradation. During hypoxia, sumoylated HIF1A also binds VHL;
the interaction promotes the ubiquitination of HIF1A. Interacts with SENP1; the interaction desumoylates HIF1A
resulting in stabilization and activation of transcription. Interacts (Via the ODD domain) with ARD1A; the
interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia. Interacts
with RWDD3; the interaction enhances HIF1A sumoylation. Interacts with TSGA10 (By similarity). Interacts with
RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing
protein stability. Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and
hypoxia-mimicking conditions. Interacts with USP20. Interacts with GNB2L1/RACK1; promotes HIF1A ubiquitination
and proteasome-mediated degradation. Interacts (via N-terminus) with USP19
Selected PDB 3D structures from and Proteopedia for HIF1A (see all 13):
1D7G (3D)        1H2K (3D)        1H2L (3D)        1H2M (3D)        1L3E (3D)        1L8C (3D)    
Secondary accessions: C0LZJ3 Q53XP6 Q96PT9 Q9UPB1
Alternative splicing: 3 isoforms:  Q16665-1   Q16665-2   Q16665-3   (Up-regulated in peripheral T lymphocytes after T-cell receptor stimulation. Highest expression in peripheral blood leukocytes and thymus)

Explore the universe of human proteins at neXtProt for HIF1A: NX_Q16665

Explore proteomics data for HIF1A at MOPED

Post-translational modifications: 

  • In normoxia, is hydroxylated on Pro-402 and Pro-564 in the oxygen-dependent degradation domain (ODD) by EGLN1/PHD1
    and EGLN2/PHD2. EGLN3/PHD3 has also been shown to hydroxylate Pro-564. The hydroxylated prolines promote
    interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Deubiquitinated by
    USP20. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in
    stabilization1
  • In normoxia, is hydroxylated on Asn-803 by HIF1AN, thus abrogating interaction with CREBBP and EP300 and
    preventing transcriptional activation. This hydroxylation is inhibited by the Cu/Zn-chelator, Clioquinol1
  • S-nitrosylation of Cys-800 may be responsible for increased recruitment of p300 coactivator necessary for
    transcriptional activity of HIF-1 complex1
  • Requires phosphorylation for DNA-binding. Phosphorylation at Ser-247 by CSNK1D/CK1 represses kinase activity and
    impairs ARNT binding. Phosphorylation by GSK3-beta and PLK3 promote degradation by the proteasome1
  • Sumoylated; with SUMO1 under hypoxia. Sumoylation is enhanced through interaction with RWDD3. Desumoylation by
    SENP1 leads to increased HIF1A stability and transriptional activity (By similarity)1
  • Ubiquitinated; in normoxia, following hydroxylation and interaction with VHL. Lys-532 appears to be the principal
    site of ubiquitination. Clioquinol, the Cu/Zn-chelator, inhibits ubiquitination through preventing hydroxylation
    at Asn-8031
  • The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains1
  • Ubiquitination2 at Lys185, Lys251, Lys297, Lys377, Lys532, Lys538, Lys547, Lys709
  • Modification sites at PhosphoSitePlus

  • See HIF1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230013.1  NP_001521.1  NP_851397.1  

    ENSEMBL proteins: 
     ENSP00000338018   ENSP00000378446   ENSP00000323326   ENSP00000451696   ENSP00000437955  
    Reactome Protein details: Q16665

    HIF1A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HIF1A
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HIF1A
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    Novus Biologicals HIF1A Proteins
    Novus Biologicals HIF1A Lysates
    Sino Biological Recombinant Protein for HIF1A
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HIF1A
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HIF1A 

     
    antibodies-online proteins for HIF1A (61 products) 

     
    antibodies-online peptides for HIF1A

    HIF1A Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of HIF1A
    R&D Systems Antibodies for HIF1A (HIF-1 alpha)
    Cell Signaling Technology (CST) Antibodies for HIF1A 
    OriGene Antibodies for HIF1A
    OriGene Custom Antibody Services for HIF1A
    Novus Biologicals HIF1A Antibodies
    Abcam antibodies for HIF1A
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for HIF1A
    LSBio Antibodies in human, mouse, rat for HIF1A
    antibodies-online antibodies for HIF1A (312 products) 

    HIF1A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIF1A
    R&D Systems ELISAs for HIF1A (HIF-1 alpha)         (see all)
    GenScript Custom Assay Services for HIF1A
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for HIF1A 
    antibodies-online kits for HIF1A (40 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    Selected InterPro protein domains (see all 7):
     IPR001321 HIF-1_alpha
     IPR014887 HIF-1_TAD_C
     IPR021537 HIF_alpha_subunit
     IPR001610 PAC
     IPR013767 PAS_fold

    Graphical View of Domain Structure for InterPro Entry Q16665

    ProtoNet protein and cluster: Q16665

    4 Blocks protein domains:
    IPB000014 PAS domain
    IPB001092 Basic helix-loop-helix dimerization domain bHLH
    IPB001321 Hypoxia-inducible factor-1 alpha signature
    IPB013655 PAS fold-3


    UniProtKB/Swiss-Prot: HIF1A_HUMAN, Q16665
    Domain: Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function
    synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID)
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain
    Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
    Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


    Find genes that share domains with HIF1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HIF1A_HUMAN, Q16665
    Function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic
    conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters,
    glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase
    oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic
    vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence
    5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires
    recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with
    both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates
    activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons
    during hypoxia
    Induction: Under reduced oxygen tension. Induced also by various receptor-mediated factors such as growth factors,
    cytokines, and circulatory factors such as PDGF, EGF, FGF2, IGF2, TGFB1, HGF, TNF, IL1B/interleukin-1 beta,
    angiotensin-2 and thrombin. However, this induction is less intense than that stimulated by hypoxia. Repressed by
    HIPK2 and LIMD1

         Genatlas biochemistry entry for HIF1A:
    hypoxia-inducible factor 1,alpha subunit,complexing with HIF2A and HIF2B (ANRT) for activation of genes involved
    in metabolism,angiogenesis,erythropoiesis and glycolysis through the recruitement of the CBP/p300
    co-activator,rapidly degraded by proteasome under normoxic conditions,binding to VHL,involved (essential) in
    cardiovascular development and systemic 02 homeostasis

         Gene Ontology (GO): Selected molecular function terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000989transcription factor binding transcription factor activity IDA--
    GO:0001076RNA polymerase II transcription factor binding transcription factor activity IEA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS15261140
         
    Find genes that share ontologies with HIF1A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HIF1A:
     Increased cell death HMECs cel 

         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Hif1a) (see all 23):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with HIF1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HIF1A: Hif1atm1.1Stom Hif1atm3.1Rsjo Hif1atm1Jhu Hif1atm1Mcs Hif1atm1Rsjo Hif1atm1Pec

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIF1A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIF1A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIF1A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIF1A

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  TACGTGCV 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIF1A:
    hsa-mir-107 (MIRT004487), hsa-mir-20b-5p (MIRT000498), hsa-mir-519c-3p (MIRT000496), hsa-mir-33a-5p (MIRT028216), hsa-let-7b-5p (MIRT051936), hsa-mir-20a-5p (MIRT000002), hsa-mir-18a-5p (MIRT004587), hsa-mir-138-5p (MIRT006744), hsa-mir-199b-5p (MIRT007022), hsa-mir-424-5p (MIRT005926), hsa-mir-106b-3p (MIRT038587)

    Block miRNA regulation of human, mouse, rat HIF1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIF1A (see all 42):
    hsa-miR-549 hsa-miR-3152-3p hsa-miR-106a hsa-miR-16-1* hsa-miR-3653 hsa-miR-519a hsa-miR-3171 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidHIF1A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HIF1A
    Predesigned siRNA for gene silencing in human, mouse, rat HIF1A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIF1A

    Clone
    Products:
         
    OriGene clones in human, mouse for HIF1A (see all 12)
    OriGene ORF clones in mouse, rat for HIF1A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HIF1A (NM_001530)
    Sino Biological Human cDNA Clone for HIF1A
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIF1A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIF1A
    Addgene plasmids for HIF1A 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF1A

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10185 VA6-14071) for HIF1A 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HIF1A_HUMAN, Q16665: Cytoplasm. Nucleus. Note=Cytoplasmic in normoxia, nuclear translocation in response to
    hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    extracellular2
    mitochondrion2
    endoplasmic reticulum1
    peroxisome1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005667transcription factor complex IPI9576906
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HIF1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIF1A About   (see all 30)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Translation Insulin regulation of translation
    Transcription Receptor mediated HIF regulation0.51
    mTOR signaling pathway0.34
    2p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    3Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH10.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer0.79
    Signaling by NOTCH0.64
    4Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen1.00
    Oxygen-dependent Asparagine Hydroxylation of Hypoxia-inducible Factor Alpha0.00
    Cellular response to hypoxia1.00
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha0.00
    Regulation of Gene Expression by Hypoxia-inducible Factor0.00
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51
    ILK Signaling0.49


    Find genes that share SuperPaths with HIF1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for HIF1A
        Notch Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for HIF1A
        ILK Signaling
    Molecular Mechanisms of Cancer
    p53 Signaling
    HIF1Alpha Pathway
    mTOR Pathway

    2 Cell Signaling Technology (CST) Pathways for HIF1A
        Translational Control
    Angiogenesis

    3 GeneGo (Thomson Reuters) Pathways for HIF1A
        Development Leptin signaling via JAK/STAT and MAPK cascades
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Transcription Receptor-mediated HIF regulation

    Selected BioSystems Pathways for HIF1A (see all 10)
        Angiogenesis
    Adipogenesis
    SIDS Susceptibility Pathways
    AGE/RAGE pathway
    VEGFR1 specific signals

    1 Sino Biological Pathway for HIF1A
        p53 Pathway

    5 Reactome Pathways for HIF1A
        NOTCH1 Intracellular Domain Regulates Transcription
    Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha
    Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
    Circadian Clock
    Regulation of gene expression by Hypoxia-inducible Factor


    Selected Kegg Pathways  (Kegg details for HIF1A) (see all 6):
        HIF-1 signaling pathway
    mTOR signaling pathway
    Thyroid hormone signaling pathway
    Pathways in cancer
    Proteoglycans in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HIF1A (see all 15): 
              mTOR Signaling in human mouse rat
              Lung Cancer in human mouse rat
              Multiple Sclerosis in human mouse rat
              VEGF Signaling in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HIF1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIF1A (Q166651, 2, 3 ENSP000003380184) via UniProtKB, MINT, STRING, and/or I2D (see all 435)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EP300Q094721, 2, 3, ENSP000002632534EBI-447269,EBI-447295 MINT-4791678 MINT-4791660 MINT-6802121 MINT-7943730 MINT-6802156 MINT-4652938 MINT-4791632 MINT-7943746 I2D: score=7 STRING: ENSP00000263253
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    ENSG00000231555P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 76):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001568blood vessel development ----
    GO:0001666response to hypoxia IMP12411310
    GO:0001755neural crest cell migration IEA--
    GO:0001837epithelial to mesenchymal transition ISS18037992

    Find genes that share ontologies with HIF1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for HIF1A
    7 ApexBio Compounds for HIF1A     About this table
    CompoundAction CAS #
    Chetomininhibits interaction of HIF-1alpha, HIF-2alpha and STAT2[1403-36-7]
    DMOGinhibits HIF-alpha prolyl hydroxylase (HIF-PH). [89464-63-1]
    FG-4592 (ASP1517)a potent small molecule inhibitor of HIF-PH[808118-40-3]
    IOX2(Glycine)potent inhibitor of HIF-1alfa prolyll hydroxylase-2 (PHD2)[931398-72-0]
    KC7F2Inhibitor of HIF-1alpha. [927822-86-4]
    ML 228HIF pathway activator [1357171-62-0]
    PX 12attenuates expression of HIF-1alpha, VEGF and iNOS[141400-58-0]

    Compounds for HIF1A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    KC7F2HIF-1alpha inhibitor; down-regulates HIF-1alpha protein synthesis[927822-86-4]
    ML 228HIF pathway activator[1357171-62-0]
    IOX 2 Potent, selective HIF-1alpha prolyl hydroxylase-2 (PHD2) inhibitor [931398-72-0]

    1 DrugBank Compound for HIF1A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for HIF1A gene (see all 132)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 92.5 2009 15256117 (9), 16964427 (9), 18025805 (9), 20003271 (9) (see all 99)
    cobalt chloride 84.7 46 18715655 (2), 16149050 (2), 18490575 (2), 16109785 (1) (see all 29)
    cocl2 79 70 16489029 (3), 12215445 (3), 17474992 (3), 15525582 (2) (see all 36)
    oxygen 78.4 471 12378005 (4), 15862307 (4), 15967517 (4), 17272744 (4) (see all 99)
    pimonidazole 74.4 24 16456867 (4), 12829158 (4), 17289019 (2), 15623619 (2) (see all 9)
    deferoxamine 69.7 101 18371939 (5), 16527254 (4), 18459142 (4), 15878351 (3) (see all 44)
    ly294002 65.6 46 11585776 (3), 10749120 (1), 11457733 (1), 15623602 (1) (see all 31)
    2-methoxyestradiol 65.5 23 15336552 (3), 19429018 (2), 19809499 (2), 18202195 (1) (see all 12)
    rapamycin 64 99 17230506 (4), 16849522 (3), 19190131 (3), 19002496 (2) (see all 45)
    geldanamycin 62.3 35 16432534 (6), 11980636 (4), 12811834 (3), 16228978 (3) (see all 11)

    1 PharmGKB related drug/compound annotation for HIF1A gene    About this table
    Drug/compound PharmGKB Annotation
    everolimus



    Find genes that share compounds with HIF1A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for HIF1A gene (3 alternative transcripts): 
    NM_001243084.1  NM_001530.3  NM_181054.2  

    Unigene Cluster for HIF1A:

    Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
    Hs.597216  [show with all ESTs]
    Unigene Representative Sequence: NM_001530
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000557446 ENST00000553999 ENST00000337138(uc010tsc.1 uc001xfq.2 uc001xfr.2)
    ENST00000394997(uc001xfs.2 uc021rua.1) ENST00000323441 ENST00000557538
    ENST00000557206 ENST00000556237 ENST00000555014 ENST00000547430 ENST00000556827
    ENST00000539097
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    Selected qRT-PCR Assays for microRNAs that regulate HIF1A (see all 42):
    hsa-miR-549 hsa-miR-3152-3p hsa-miR-106a hsa-miR-16-1* hsa-miR-3653 hsa-miR-519a hsa-miR-3171 hsa-miR-93
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    Addgene plasmids for HIF1A 
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10185 VA6-14071) for HIF1A 

    Additional mRNA sequence: 

    AB073325.1 AB500182.1 AB733094.1 AF207601.1 AF207602.1 AF304431.1 AK296876.1 AK299551.1 
    AK304315.1 AK304436.1 AK312397.1 BC012527.2 BT009776.1 BX648795.1 DQ975378.1 FJ790247.1 
    U22431.1 U29165.1 U85044.1 X72726.1 

    Selected DOTS entries (see all 32):

    DT.448859  DT.120747150  DT.100828291  DT.120747034  DT.95328228  DT.120747024  DT.95361808  DT.100828293 
    DT.120747160  DT.40132945  DT.95241728  DT.95361839  DT.97813592  DT.100672723  DT.100828289  DT.100828296 
    DT.100828298  DT.120747179  DT.75110718  DT.75130521  DT.92035848  DT.92456711  DT.95072045  DT.95146965 

    7 AceView cDNA sequences:

    BF869719 AK093749 AI510796 BF848384 AV648847 BU664561 AW800170 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HIF1A    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                      -                                                                     
    SP2:                                      -                                                                     
    SP3:                                      -                                                           -         
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for HIF1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIF1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGATTTCAA
    HIF1A Expression
    About this image


    HIF1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Hypertrophic Chondrocytes Rib
             Bone Marrow
             Bone marrow-derived mesenchymal stem cells (Stemedyne-MSC)
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Retina
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells (Stemedyne-MSC)
    HIF1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIF1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.597216

    UniProtKB/Swiss-Prot: HIF1A_HUMAN, Q16665
    Tissue specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the
    majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a
    result of mutations in genes encoding oncoproteins and tumor suppressors

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HIF1A (see all 15): 
              mTOR Signaling in human mouse rat
              Lung Cancer in human mouse rat
              Multiple Sclerosis in human mouse rat
              VEGF Signaling in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HIF1A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hif1a1 , 5 hypoxia inducible factor 1, alpha subunit1, 5 88.79(n)1
    90.38(a)1
      12 (31.99 cM)5
    152511  NM_010431.21  NP_034561.21 
     739013755 
    chicken
    (Gallus gallus)
    Aves HIF1A1 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix more 79.2(n)
    79.65(a)
      374177  NM_204297.1  NP_989628.1 
    lizard
    (Anolis carolinensis)
    Reptilia HIF1A6
    hypoxia inducible factor 1, alpha subunit (basic h...
    76(a)
    1 ↔ 1
    1(3182652-3208207)
    African clawed frog
    (Xenopus laevis)
    Amphibia hif1a-prov2 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix more 77.2(n)    BC043769.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554052 similar to hypoxia-inducible factor 1, alpha subunit more 72.89(n)   393202  BC046875.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sima3 regulation of transcription,
    DNA-dependent RNA more
    41(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hif-16
    Protein HIF-1, isoform e
    22(a)
    1 → many
    V(20780413-20785258) WBGene00001851


    ENSEMBL Gene Tree for HIF1A (if available)
    TreeFam Gene Tree for HIF1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIF1A gene
    ARNT22  CLOCK2  NPAS22  AHR2  ARNT2  EPAS12  NPAS32  SIM22  
    SIM12  HIF3A2  ARNTL2  NPAS12  ARNTL22  AHRR2  
    4 SIMAP similar genes for HIF1A using alignment to 4 protein entries:     HIF1A_HUMAN (see all proteins):
    EPAS1    SIM2    NPAS3    HIF3A

    Find genes that share paralogs with HIF1A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for HIF1A
    PGOHUM00000247859


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIF1A (see all 1145)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs718953981,2
    C--42375473(+) ATTTC-/GTGT  
            
    GTGTG
    3 -- int10--------
    rs58091211,2
    C--42377820(+) TTCAAT/-TTTTG 3 -- ut314Minor allele frequency- -:0.11NA CSA 54
    rs1512839921,2
    C--43145116(+) GTGGTA/GCGTGC 2 -- us2k10--------
    rs49020791,2
    C,H--43145117(+) TGGTGG/CGTGCC 2 -- us2k19Minor allele frequency- C:0.00NA WA CSA 16
    rs1857804211,2
    --43145131(+) AATCCC/TAGCTA 2 -- us2k10--------
    rs1500023231,2
    --43145315(+) TGCTTA/GCTATG 2 -- us2k10--------
    rs101460371,2
    C,F,A,H--43145340(+) ctaagT/Cataca 2 -- us2k1 tfbs39Minor allele frequency- C:0.18NS EA CSA WA NA 778
    rs1450097721,2
    --43145493(+) TGGAGC/GCAGTG 2 -- us2k10--------
    rs1381414471,2
    C--43145563(+) TCCAC-/AATTAA 2 -- us2k10--------
    rs1421290631,2
    C--43145647(+) AATACA/GTATCA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for HIF1A (62162119 - 62214977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HIF1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902008CNV Loss21882294
    nsv1300CNV Loss18451855

    Human Gene Mutation Database (HGMD): HIF1A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIF1A
    DNA2.0 Custom Variant and Variant Library Synthesis for HIF1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603348    OMIM disorders: --

    Selected diseases for HIF1A (see all 23):    
    About MalaCards
    supraglottic laryngeal cancer    breast fibroadenoma    retinal ischemia    hypoxia
    transitional meningioma    fumarate hydratase deficiency    pulmonary arteriovenous malformation    cervical cancer
    nodular malignant melanoma    spontaneous pneumothorax    arteriovenous malformation    primary spontaneous pneumothorax
    von hippel-lindau disease    endolymphatic sac tumor    pericardial effusion    ankylosis
    acute mountain sickness    brain injury    sle susceptibility    diabetic retinopathy

    3 diseases from the University of Copenhagen DISEASES database for HIF1A:
    Cancer     Vascular disease     Heart disease

    Find genes that share disorders with HIF1A           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HIF1A gene (see all 97)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 76.9 1247 12795846 (6), 18025805 (6), 19893619 (6), 19689405 (5) (see all 99)
    cancer 70.5 378 19080625 (5), 19689405 (4), 20078552 (4), 17914567 (3) (see all 99)
    solid tumor 68.7 36 16682946 (2), 10945599 (2), 18503779 (2), 17404022 (1) (see all 27)
    renal clear cell carcinoma 68.5 24 11431362 (5), 15062033 (3), 16600797 (3), 17064593 (3) (see all 11)
    carcinoma renal cell 64.5 76 19526589 (4), 19816521 (4), 16109571 (2), 17922867 (2) (see all 48)
    metastasis 62.8 235 20164027 (5), 16251878 (4), 15849727 (4), 17028975 (4) (see all 99)
    neovascularization 57.5 12 18528739 (2), 15786555 (2), 10640274 (1), 16552951 (1) (see all 10)
    retinal neovascularization 55.9 8 18853324 (3), 15834450 (1), 18307947 (1), 18767037 (1)
    aggressiveness 53.8 16 17088993 (1), 20431729 (1), 20514449 (1), 16103077 (1) (see all 14)
    prostate cancer 50 126 9850048 (4), 16954428 (4), 19102499 (4), 15791851 (3) (see all 61)

    Genetic Association Database (GAD): HIF1A
    Human Genome Epidemiology (HuGE) Navigator: HIF1A (88 documents)

    Export disorders for HIF1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIF1A gene, integrated from 10 sources (see all 2951):
    (articles sorted by number of sources associating them with HIF1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. (PubMed id 9079689)1, 2, 3, 9 Hogenesch J.B.... Bradfield C.A. (J. Biol. Chem. 1997)
    2. HIF-1 alpha protein as a target for S-nitrosation. (PubMed id 12560087)1, 2, 9 Sumbayev V.V.... Bruene B. (FEBS Lett. 2003)
    3. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. (PubMed id 10944113)1, 2, 9 Tanimoto K.... Poellinger L. (EMBO J. 2000)
    4. Sumoylation increases HIF-1alpha stability and its transcriptional activity. (PubMed id 15465032)1, 2, 9 Bae S.-H....Kim K.-W. (Biochem. Biophys. Res. Commun. 2004)
    5. C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer. (PubMed id 16837101)1, 4, 9 Koukourakis M.I....Sivridis E. (Lung Cancer 2006)
    6. Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha. (PubMed id 16288748)1, 2, 9 Arnesen T.... Lillehaug J.R. (FEBS Lett. 2005)
    7. VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha. (PubMed id 15776016)1, 2, 9 Li Z.... Wu G. (EMBO Rep. 2005)
    8. The association between hypoxia inducible factor-1alpha gene polymorphisms and increased susceptibility to oral cancer. (PubMed id 19717330)1, 4, 9 Chen M.K....Yang S.F. (Oral Oncol. 2009)
    9. Two hypoxia sensor genes and their association with symptoms of acute mountain sickness in Sherpas. (PubMed id 18998488)1, 4, 9 Droma Y....Kubo K. (Aviat Space Environ Med 2008)
    10. Single nucleotide polymorphisms in the hypoxia-inducible factor-1alpha (HIF-1alpha) gene in human sporadic breast cancer. (PubMed id 18279708)1, 4, 9 Apaydin I....Ekmekci A. (Arch. Med. Res. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3091 HGNC: 4910 AceView: HIF1A.1 Ensembl:ENSG00000100644 euGenes: HUgn3091
    ECgene: HIF1A Kegg: 3091 H-InvDB: HIF1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIF1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HIF1A Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Hypoxia_inducible_factor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIF1A gene:
    Search GeneIP for patents involving HIF1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Block miRNA regulation of human, mouse, rat HIF1A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HIF1A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIF1A Predesigned siRNA for gene silencing in human, mouse, rat HIF1A
     QuantiFast Probe-based Assays in human, mouse, rat HIF1A QuantiTect SYBR Green Assays in human, mouse, rat HIF1A
     PCR Arrays including human, mouse, rat HIF1A Search Chromatin IP Primers for HIF1A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIF1A  GeneGlobe Interaction Network for HIF1A
     Regulatory tfbs in HIF1A promoter
     GenScript Custom Purified and Recombinant Proteins Services for HIF1A GenScript cDNA clones with any tag delivered in your preferred vector for HIF1A
     GenScript Custom Assay Services for HIF1A GenScript Custom overexpressing Cell Line Services for HIF1A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Antibodies & Assays for HIF1A 

     Tocris compounds for HIF1A
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     Browse Sino Biological Cell Lysates
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     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Antibodies for HIF1A
     See all of Abcam's Antibodies, Kits and Proteins for HIF1A
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for HIF1A
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for HIF1A
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIF1A
     SwitchGear 3'UTR luciferase reporter plasmids for HIF1A
     SwitchGear Promoter luciferase reporter plasmids for HIF1A
     ThermoFisher Antibody for HIF1A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIF1A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIF1A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIF1A
     LSBio Antibodies in human, mouse, rat for HIF1A
     ApexBio compounds for HIF1A
     Addgene plasmids for HIF1A
      Search eBioscience for proteins for HIF1A
      Search eBioscience for elisas for HIF1A
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
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     antibodies-online antibodies for HIF1A (312 products)
     antibodies-online kits for HIF1A (40 products)
     antibodies-online peptides for HIF1A
     antibodies-online proteins for HIF1A (61 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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