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Aliases for HID1 Gene

Aliases for HID1 Gene

  • HID1 Domain Containing 2 3 5
  • Down-Regulated In Multiple Cancers 1 3 4
  • Downregulated In Multiple Cancer 1 2 3
  • HID1 Domain-Containing Protein 3 4
  • Protein Hid-1 Homolog 3 4
  • C17orf28 3 4
  • DMC1 3 4
  • UPF0663 Transmembrane Protein C17orf28 3
  • Chromosome 17 Open Reading Frame 28 2
  • HID-1 3

External Ids for HID1 Gene

Previous HGNC Symbols for HID1 Gene

  • C17orf28

Previous GeneCards Identifiers for HID1 Gene

  • GC17M072947

Summaries for HID1 Gene

GeneCards Summary for HID1 Gene

HID1 (HID1 Domain Containing) is a Protein Coding gene. Diseases associated with HID1 include palmoplantar keratoderma, nonepidermolytic. Among its related pathways are Cell Cycle, Mitotic and Meiosis.

UniProtKB/Swiss-Prot for HID1 Gene

  • May play an important role in the development of cancers in a broad range of tissues.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HID1 Gene

Genomics for HID1 Gene

Regulatory Elements for HID1 Gene

Promoters for HID1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HID1 on UCSC Golden Path with GeneCards custom track

Genomic Location for HID1 Gene

Chromosome:
17
Start:
74,950,742 bp from pter
End:
74,973,166 bp from pter
Size:
22,425 bases
Orientation:
Minus strand

Genomic View for HID1 Gene

Genes around HID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HID1 Gene

Proteins for HID1 Gene

  • Protein details for HID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV36-HID1_HUMAN
    Recommended name:
    Protein HID1
    Protein Accession:
    Q8IV36
    Secondary Accessions:
    • Q8N5L6
    • Q8TE83
    • Q9NT34

    Protein attributes for HID1 Gene

    Size:
    788 amino acids
    Molecular mass:
    88745 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85070.1; Type=Frameshift; Positions=594; Evidence={ECO:0000305};

    Alternative splice isoforms for HID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HID1 Gene

Proteomics data for HID1 Gene at MOPED

Post-translational modifications for HID1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HID1 Gene

No data available for DME Specific Peptides for HID1 Gene

Domains & Families for HID1 Gene

Protein Domains for HID1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IV36

UniProtKB/Swiss-Prot:

HID1_HUMAN :
  • Belongs to the hid-1 family.
Family:
  • Belongs to the hid-1 family.
genes like me logo Genes that share domains with HID1: view

No data available for Gene Families for HID1 Gene

Function for HID1 Gene

Molecular function for HID1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the development of cancers in a broad range of tissues.
genes like me logo Genes that share phenotypes with HID1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HID1 Gene

Localization for HID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HID1 Gene

Cytoplasm. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the cytosol and the Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HID1 Gene COMPARTMENTS Subcellular localization image for HID1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
golgi apparatus 5
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000138 Golgi trans cisterna IDA 21337012
GO:0005737 cytoplasm IDA 21337012
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HID1: view

Pathways & Interactions for HID1 Gene

genes like me logo Genes that share pathways with HID1: view

Pathways by source for HID1 Gene

1 BioSystems pathway for HID1 Gene
3 Reactome pathways for HID1 Gene

Gene Ontology (GO) - Biological Process for HID1 Gene

None

No data available for SIGNOR curated interactions for HID1 Gene

Drugs & Compounds for HID1 Gene

No Compound Related Data Available

Transcripts for HID1 Gene

Unigene Clusters for HID1 Gene

HID1 domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HID1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ·
SP1: - - -
SP2:
SP3: - - - - - - -
SP4: -
SP5: - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - -
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -

Relevant External Links for HID1 Gene

GeneLoc Exon Structure for
HID1
ECgene alternative splicing isoforms for
HID1

Expression for HID1 Gene

mRNA expression in normal human tissues for HID1 Gene

mRNA differential expression in normal tissues according to GTEx for HID1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8), Brain - Cerebellar Hemisphere (x5.3), and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for HID1 Gene

This gene is overexpressed in Stomach (36.9) and Salivary gland (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HID1 Gene



SOURCE GeneReport for Unigene cluster for HID1 Gene Hs.11067

mRNA Expression by UniProt/SwissProt for HID1 Gene

Q8IV36-HID1_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines.
genes like me logo Genes that share expression patterns with HID1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HID1 Gene

Orthologs for HID1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HID1 36
  • 100 (a)
OneToOne
HID1 35
  • 99.2 (n)
  • 99.75 (a)
cow
(Bos Taurus)
Mammalia HID1 35
  • 91.95 (n)
  • 96.06 (a)
HID1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HID1 36
  • 96 (a)
OneToOne
HID1 35
  • 91.73 (n)
  • 96.34 (a)
mouse
(Mus musculus)
Mammalia Hid1 36
  • 96 (a)
OneToOne
Hid1 16
Hid1 35
  • 88.87 (n)
  • 95.69 (a)
oppossum
(Monodelphis domestica)
Mammalia HID1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hid1 35
  • 88.75 (n)
  • 95.3 (a)
chicken
(Gallus gallus)
Aves C17ORF28 35
  • 80.75 (n)
  • 90.86 (a)
HID1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HID1 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24293 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hid1 35
  • 75.3 (n)
  • 82.99 (a)
MGC76040 35
zebrafish
(Danio rerio)
Actinopterygii hid1b 35
  • 69.01 (n)
  • 73.56 (a)
hid1a 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011570 35
  • 67.39 (n)
  • 69.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8841 35
  • 65.15 (n)
  • 68.48 (a)
CG8841 36
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hid-1 36
  • 60 (a)
OneToOne
hid-1 35
  • 58.75 (n)
  • 60.89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11335 35
  • 48.85 (n)
  • 37.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ftp105 35
  • 38.73 (n)
  • 29.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for HID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HID1 Gene

ENSEMBL:
Gene Tree for HID1 (if available)
TreeFam:
Gene Tree for HID1 (if available)

Paralogs for HID1 Gene

(1) SIMAP similar genes for HID1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HID1: view

No data available for Paralogs for HID1 Gene

Variants for HID1 Gene

Sequence variations from dbSNP and Humsavar for HID1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2307010 -- 74,953,051(+) GTGGA(C/T)GGTCG reference, synonymous-codon
rs2307011 -- 74,953,072(+) CTCCA(C/T)GCCTG reference, synonymous-codon
rs2087718 -- 74,953,554(+) TTAGC(C/T)GGGCT reference, synonymous-codon
rs3744198 -- 74,960,029(+) ACATC(A/G)GCATC reference, synonymous-codon
rs3744199 -- 74,960,304(+) CCTGG(A/C)CACAC intron-variant

Variation tolerance for HID1 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HID1 Gene

HapMap Linkage Disequilibrium report
HID1
Human Gene Mutation Database (HGMD)
HID1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HID1 Gene

Disorders for HID1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HID1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
palmoplantar keratoderma, nonepidermolytic
  • nonepidermolytic palmoplantar keratoderma
- elite association - COSMIC cancer census association via MalaCards
Search HID1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HID1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HID1
genes like me logo Genes that share disorders with HID1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HID1 Gene

Publications for HID1 Gene

  1. Identification of DMC1, a novel gene in the TOC region on 17q25.1 that shows loss of expression in multiple human cancers. (PMID: 11281419) Harada H. … Emi M. (J. Hum. Genet. 2001) 2 3 4 23 67
  2. HID-1 is a peripheral membrane protein primarily associated with the medial- and trans- Golgi apparatus. (PMID: 21337012) Wang L. … Xu T. (Protein Cell 2011) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for HID1 Gene

Sources for HID1 Gene

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