Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HID1 Gene

Aliases for HID1 Gene

  • HID1 Domain Containing 2 3 5
  • Down-Regulated In Multiple Cancers 1 3 4
  • Downregulated In Multiple Cancer 1 2 3
  • HID1 Domain-Containing Protein 3 4
  • Protein Hid-1 Homolog 3 4
  • C17orf28 3 4
  • DMC1 3 4
  • UPF0663 Transmembrane Protein C17orf28 3
  • Chromosome 17 Open Reading Frame 28 2
  • Protein HID1 3
  • HID-1 3

External Ids for HID1 Gene

Previous HGNC Symbols for HID1 Gene

  • C17orf28

Previous GeneCards Identifiers for HID1 Gene

  • GC17M072947

Summaries for HID1 Gene

GeneCards Summary for HID1 Gene

HID1 (HID1 Domain Containing) is a Protein Coding gene. Diseases associated with HID1 include Palmoplantar Keratoderma, Nonepidermolytic.

UniProtKB/Swiss-Prot for HID1 Gene

  • May play an important role in the development of cancers in a broad range of tissues.

Additional gene information for HID1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HID1 Gene

Genomics for HID1 Gene

Regulatory Elements for HID1 Gene

Enhancers for HID1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H075010 1.7 FANTOM5 ENCODE dbSUPER 22.6 -39.0 -39037 3.7 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A UNK GGA3 HID1 NUP85 CDK3 NT5C ENSG00000266980 KCTD2 CDR2L ENSG00000264829
GH17H074986 1.7 FANTOM5 ENCODE dbSUPER 19.9 -15.0 -15023 2.9 HDGF ATF1 ARID4B SIN3A FEZF1 GLIS2 FOS ATF7 SP3 SP5 HID1 KCTD2 MRPL38 ATP5H CDR2L RAB37 GC17M074998
GH17H074511 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +459.6 459563 3.3 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF302 ZNF416 ZNF207 NUP85 NAT9 NT5C GGA3 RN7SL573P HID1-AS1 CD300E CDR2L CD300A ENSG00000266765
GH17H074969 1.2 ENCODE dbSUPER 20.8 +1.5 1515 3.4 FOXA2 ARID4B SIN3A DMAP1 ZNF121 GLIS2 SP3 SP5 NFIL3 SSRP1 HID1 OTOP3 UNK KCTD2 RNU6-362P ATP5H NUP85 ENSG00000266980 HID1-AS1
GH17H075085 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 -118.3 -118330 11.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 NUP85 UNK NT5C ENSG00000266980 ENSG00000267342 NAT9 GGA3 TRIM65 RN7SL573P SAP30BP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HID1 on UCSC Golden Path with GeneCards custom track

Promoters for HID1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098293 566 801 FOXA2 ARID4B DMAP1 ZNF121 SP3 SP5 NFIL3 SSRP1 MIER3 GLIS1

Genomic Locations for HID1 Gene

Genomic Locations for HID1 Gene
22,425 bases
Minus strand

Genomic View for HID1 Gene

Genes around HID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HID1 Gene

Proteins for HID1 Gene

  • Protein details for HID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein HID1
    Protein Accession:
    Secondary Accessions:
    • Q8N5L6
    • Q8TE83
    • Q9NT34

    Protein attributes for HID1 Gene

    788 amino acids
    Molecular mass:
    88745 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB85070.1; Type=Frameshift; Positions=594; Evidence={ECO:0000305};

    Alternative splice isoforms for HID1 Gene


neXtProt entry for HID1 Gene

Post-translational modifications for HID1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HID1 Gene

No data available for DME Specific Peptides for HID1 Gene

Domains & Families for HID1 Gene

Gene Families for HID1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HID1 Gene


Suggested Antigen Peptide Sequences for HID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the hid-1 family.
  • Belongs to the hid-1 family.
genes like me logo Genes that share domains with HID1: view

Function for HID1 Gene

Molecular function for HID1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the development of cancers in a broad range of tissues.

Phenotypes From GWAS Catalog for HID1 Gene

Gene Ontology (GO) - Molecular Function for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20368287
genes like me logo Genes that share ontologies with HID1: view
genes like me logo Genes that share phenotypes with HID1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HID1 Gene

Localization for HID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HID1 Gene

Cytoplasm. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the cytosol and the Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HID1 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
golgi apparatus 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000138 Golgi trans cisterna IDA 21337012
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA,IEA 21337012
GO:0005794 Golgi apparatus IDA --
GO:0005797 Golgi medial cisterna IDA 21337012
genes like me logo Genes that share ontologies with HID1: view

Pathways & Interactions for HID1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IDA 21337012
GO:0031001 response to brefeldin A IDA 21337012
genes like me logo Genes that share ontologies with HID1: view

No data available for Pathways by source and SIGNOR curated interactions for HID1 Gene

Drugs & Compounds for HID1 Gene

No Compound Related Data Available

Transcripts for HID1 Gene

Unigene Clusters for HID1 Gene

HID1 domain containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HID1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ·
SP1: - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - -
SP6: - - - - -
SP8: - - - - - -
SP9: -
SP10: - -

ExUns: 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: - - -
SP7: - -
SP14: -

Relevant External Links for HID1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HID1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HID1 Gene

mRNA differential expression in normal tissues according to GTEx for HID1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8), Brain - Cerebellar Hemisphere (x5.3), and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for HID1 Gene

This gene is overexpressed in Stomach (36.9) and Salivary gland (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HID1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HID1 Gene:


SOURCE GeneReport for Unigene cluster for HID1 Gene:


mRNA Expression by UniProt/SwissProt for HID1 Gene:

Tissue specificity: Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines.

Evidence on tissue expression from TISSUES for HID1 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with HID1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HID1 Gene

Orthologs for HID1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HID1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HID1 33 34
  • 99.2 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
-- 34
  • 90 (a)
(Bos Taurus)
Mammalia HID1 33 34
  • 91.95 (n)
(Canis familiaris)
Mammalia HID1 33 34
  • 91.73 (n)
(Monodelphis domestica)
Mammalia HID1 34
  • 91 (a)
(Mus musculus)
Mammalia Hid1 33 16 34
  • 88.87 (n)
(Rattus norvegicus)
Mammalia Hid1 33
  • 88.75 (n)
(Gallus gallus)
Aves HID1 34
  • 89 (a)
C17ORF28 33
  • 80.75 (n)
(Anolis carolinensis)
Reptilia HID1 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hid1 33
  • 75.3 (n)
MGC76040 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24293 33
(Danio rerio)
Actinopterygii hid1a 34
  • 74 (a)
hid1b 33
  • 69.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011570 33
  • 67.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8841 33 34
  • 65.15 (n)
(Caenorhabditis elegans)
Secernentea hid-1 33 34
  • 58.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11335 33
  • 48.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ftp105 33
  • 38.73 (n)
Species where no ortholog for HID1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HID1 Gene

Gene Tree for HID1 (if available)
Gene Tree for HID1 (if available)

Paralogs for HID1 Gene

(1) SIMAP similar genes for HID1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HID1: view

No data available for Paralogs for HID1 Gene

Variants for HID1 Gene

Sequence variations from dbSNP and Humsavar for HID1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000153780 -- 74,970,377(+) TGTCA(A/C)CATGC intron-variant, upstream-variant-2KB
rs1000324891 -- 74,959,232(+) CGGAG(A/T)CCCTC intron-variant
rs1000364735 -- 74,970,951(+) TGGTC(A/T)GATCT intron-variant
rs1000392067 -- 74,971,238(+) CTTCC(C/T)CCCTG intron-variant
rs1000601150 -- 74,958,550(+) ATTTT(A/G)GAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HID1 Gene

Variant ID Type Subtype PubMed ID
nsv952367 CNV deletion 24416366
nsv833540 CNV loss 17160897
nsv819301 CNV gain 19587683
nsv576026 CNV gain 21841781
nsv518292 CNV loss 19592680
nsv470601 CNV loss 18288195
nsv457909 CNV gain 19166990
nsv1056788 CNV gain 25217958

Variation tolerance for HID1 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HID1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HID1 Gene

Disorders for HID1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HID1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
palmoplantar keratoderma, nonepidermolytic
  • nonepidermolytic palmoplantar keratoderma
- elite association - COSMIC cancer census association via MalaCards
Search HID1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HID1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HID1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HID1 Gene

Publications for HID1 Gene

  1. Identification of DMC1, a novel gene in the TOC region on 17q25.1 that shows loss of expression in multiple human cancers. (PMID: 11281419) Harada H … Emi M (Journal of human genetics 2001) 2 3 4 22 60
  2. HID-1 is a peripheral membrane protein primarily associated with the medial- and trans- Golgi apparatus. (PMID: 21337012) Wang L … Xu T (Protein & cell 2011) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for HID1 Gene

Sources for HID1 Gene

Loading form....