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Aliases for HID1 Gene

Aliases for HID1 Gene

  • HID1 Domain Containing 2 3 5
  • Down-Regulated In Multiple Cancers 1 3 4
  • Downregulated In Multiple Cancer 1 2 3
  • HID1 Domain-Containing Protein 3 4
  • Protein Hid-1 Homolog 3 4
  • C17orf28 3 4
  • DMC1 3 4
  • UPF0663 Transmembrane Protein C17orf28 3
  • Chromosome 17 Open Reading Frame 28 2
  • Protein HID1 3
  • HID-1 3

External Ids for HID1 Gene

Previous HGNC Symbols for HID1 Gene

  • C17orf28

Previous GeneCards Identifiers for HID1 Gene

  • GC17M072947

Summaries for HID1 Gene

GeneCards Summary for HID1 Gene

HID1 (HID1 Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for HID1 Gene

  • May play an important role in the development of cancers in a broad range of tissues.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HID1 Gene

Genomics for HID1 Gene

Regulatory Elements for HID1 Gene

Enhancers for HID1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F075010 1.2 FANTOM5 ENCODE 22.5 -39.0 -39037 3.7 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 UNK HID1 ENSG00000267801 ENSG00000266980 ENSG00000264829 NUP85 KCTD2 CDR2L NT5C HID1-AS1
GH17F074969 0.5 ENCODE 20.8 +1.5 1515 3.4 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 SP3 SP5 SSRP1 HID1 OTOP3 KCTD2 RNU6-362P ATP5H HID1-AS1
GH17F074986 1.1 FANTOM5 ENCODE 19.9 -15.0 -15023 2.9 ATF1 CREB3L1 ARID4B SIN3A FEZF1 ZNF48 YY1 GLIS2 FOS ZNF263 HID1 KCTD2 MRPL38 ATP5H CDR2L RAB37 GC17M074998
GH17F074989 0.9 Ensembl ENCODE 14.4 -18.8 -18795 4.1 SIN3A ARID4B FEZF1 ZNF2 ZNF48 ZNF121 ZNF143 REST MIER3 KDM1A HID1 RNU6-362P OTOP3 KCTD2 ATP5H FADS6 MRPL58 CDR2L GC17M074998
GH17F075018 0.6 ENCODE 14 -45.7 -45659 0.4 BCOR MTA2 TAL1 ARID1B MEF2D NCOR1 GATA2 ADNP TRIM24 HID1 CDR2L ATP5H MRPL58 GC17M075029
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HID1 on UCSC Golden Path with GeneCards custom track

Promoters for HID1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001809889 966 2001 MLX ARID4B SIN3A DMAP1 ZNF48 ZNF121 GLIS2 SP3 SP5 SSRP1

Genomic Location for HID1 Gene

Chromosome:
17
Start:
74,950,742 bp from pter
End:
74,973,166 bp from pter
Size:
22,425 bases
Orientation:
Minus strand

Genomic View for HID1 Gene

Genes around HID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HID1 Gene

Proteins for HID1 Gene

  • Protein details for HID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV36-HID1_HUMAN
    Recommended name:
    Protein HID1
    Protein Accession:
    Q8IV36
    Secondary Accessions:
    • Q8N5L6
    • Q8TE83
    • Q9NT34

    Protein attributes for HID1 Gene

    Size:
    788 amino acids
    Molecular mass:
    88745 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85070.1; Type=Frameshift; Positions=594; Evidence={ECO:0000305};

    Alternative splice isoforms for HID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HID1 Gene

Post-translational modifications for HID1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HID1 Gene

No data available for DME Specific Peptides for HID1 Gene

Domains & Families for HID1 Gene

Protein Domains for HID1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IV36

UniProtKB/Swiss-Prot:

HID1_HUMAN :
  • Belongs to the hid-1 family.
Family:
  • Belongs to the hid-1 family.
genes like me logo Genes that share domains with HID1: view

No data available for Gene Families for HID1 Gene

Function for HID1 Gene

Molecular function for HID1 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the development of cancers in a broad range of tissues.

Gene Ontology (GO) - Molecular Function for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20368287
genes like me logo Genes that share ontologies with HID1: view
genes like me logo Genes that share phenotypes with HID1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HID1 Gene

Localization for HID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HID1 Gene

Cytoplasm. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the cytosol and the Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HID1 Gene COMPARTMENTS Subcellular localization image for HID1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
golgi apparatus 5
cytosol 3
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000138 Golgi trans cisterna IDA 21337012
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IDA 21337012
GO:0005794 Golgi apparatus IDA --
GO:0005797 Golgi medial cisterna IDA 21337012
genes like me logo Genes that share ontologies with HID1: view

Pathways & Interactions for HID1 Gene

SuperPathways for HID1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IDA 21337012
GO:0031001 response to brefeldin A IDA 21337012
genes like me logo Genes that share ontologies with HID1: view

No data available for Pathways by source and SIGNOR curated interactions for HID1 Gene

Transcripts for HID1 Gene

Unigene Clusters for HID1 Gene

HID1 domain containing:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HID1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ·
SP1: - - -
SP2:
SP3: - - - - - - -
SP4: -
SP5: - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - -
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -

Relevant External Links for HID1 Gene

GeneLoc Exon Structure for
HID1
ECgene alternative splicing isoforms for
HID1

Expression for HID1 Gene

mRNA expression in normal human tissues for HID1 Gene

mRNA differential expression in normal tissues according to GTEx for HID1 Gene

This gene is overexpressed in Brain - Cerebellum (x5.8), Brain - Cerebellar Hemisphere (x5.3), and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for HID1 Gene

This gene is overexpressed in Stomach (36.9) and Salivary gland (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HID1 Gene



NURSA nuclear receptor signaling pathways regulating expression of HID1 Gene:

HID1

SOURCE GeneReport for Unigene cluster for HID1 Gene:

Hs.11067

mRNA Expression by UniProt/SwissProt for HID1 Gene:

Q8IV36-HID1_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines.
genes like me logo Genes that share expression patterns with HID1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for HID1 Gene

Orthologs for HID1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HID1 34 35
  • 99.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia HID1 34 35
  • 91.95 (n)
dog
(Canis familiaris)
Mammalia HID1 34 35
  • 91.73 (n)
oppossum
(Monodelphis domestica)
Mammalia HID1 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hid1 34 16 35
  • 88.87 (n)
rat
(Rattus norvegicus)
Mammalia Hid1 34
  • 88.75 (n)
chicken
(Gallus gallus)
Aves HID1 35
  • 89 (a)
OneToOne
C17ORF28 34
  • 80.75 (n)
lizard
(Anolis carolinensis)
Reptilia HID1 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hid1 34
  • 75.3 (n)
MGC76040 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24293 34
zebrafish
(Danio rerio)
Actinopterygii hid1a 35
  • 74 (a)
OneToOne
hid1b 34
  • 69.01 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011570 34
  • 67.39 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8841 34 35
  • 65.15 (n)
worm
(Caenorhabditis elegans)
Secernentea hid-1 34 35
  • 58.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 69 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU11335 34
  • 48.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ftp105 34
  • 38.73 (n)
Species where no ortholog for HID1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HID1 Gene

ENSEMBL:
Gene Tree for HID1 (if available)
TreeFam:
Gene Tree for HID1 (if available)

Paralogs for HID1 Gene

(1) SIMAP similar genes for HID1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HID1: view

No data available for Paralogs for HID1 Gene

Variants for HID1 Gene

Sequence variations from dbSNP and Humsavar for HID1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1044433 -- 74,950,966(-) GATCC(A/G)TGGAA nc-transcript-variant, utr-variant-3-prime
rs10719287 -- 74,961,868(+) GGCCC(-/T)TCACC intron-variant
rs11077767 -- 74,960,745(+) CTTCT(C/G)TTCTG intron-variant
rs111299695 -- 74,958,445(+) GCAAG(A/G)TGAAG nc-transcript-variant, reference, missense
rs111414043 -- 74,957,993(+) CTTTT(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HID1 Gene

Variant ID Type Subtype PubMed ID
nsv1056788 CNV gain 25217958
nsv457909 CNV gain 19166990
nsv470601 CNV loss 18288195
nsv518292 CNV loss 19592680
nsv576026 CNV gain 21841781
nsv819301 CNV gain 19587683
nsv833540 CNV loss 17160897
nsv952367 CNV deletion 24416366

Variation tolerance for HID1 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HID1 Gene

Human Gene Mutation Database (HGMD)
HID1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HID1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HID1 Gene

Disorders for HID1 Gene

Relevant External Links for HID1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HID1

No disorders were found for HID1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HID1 Gene

Publications for HID1 Gene

  1. Identification of DMC1, a novel gene in the TOC region on 17q25.1 that shows loss of expression in multiple human cancers. (PMID: 11281419) Harada H. … Emi M. (J. Hum. Genet. 2001) 2 3 4 22 64
  2. HID-1 is a peripheral membrane protein primarily associated with the medial- and trans- Golgi apparatus. (PMID: 21337012) Wang L. … Xu T. (Protein Cell 2011) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. (PMID: 25464930) Shen C. … Zhong N. (J. Mol. Neurosci. 2015) 3 64

Products for HID1 Gene

Sources for HID1 Gene

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