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Aliases for HID1 Gene

Aliases for HID1 Gene

  • HID1 Domain Containing 2 3
  • C17orf28 3 4 6
  • DMC1 3 4 6
  • Down-Regulated In Multiple Cancers 1 3 4
  • Downregulated In Multiple Cancer 1 2 3
  • HID1 Domain-Containing Protein 3 4
  • Protein Hid-1 Homolog 3 4
  • UPF0663 Transmembrane Protein C17orf28 3
  • Chromosome 17 Open Reading Frame 28 2
  • Protein HID1 3
  • HID-1 3

External Ids for HID1 Gene

Previous HGNC Symbols for HID1 Gene

  • C17orf28

Previous GeneCards Identifiers for HID1 Gene

  • GC17M072947

Summaries for HID1 Gene

GeneCards Summary for HID1 Gene

HID1 (HID1 Domain Containing) is a Protein Coding gene. Among its related pathways are Meiosis and Meiosis.

UniProtKB/Swiss-Prot for HID1 Gene

  • May play an important role in the development of cancers in a broad range of tissues.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HID1 Gene

Genomics for HID1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HID1 Gene

Start:
74,950,742 bp from pter
End:
74,973,166 bp from pter
Size:
22,425 bases
Orientation:
Minus strand

Genomic View for HID1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HID1 Gene

No data available for Regulatory Elements for HID1 Gene

Proteins for HID1 Gene

  • Protein details for HID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IV36-HID1_HUMAN
    Recommended name:
    Protein HID1
    Protein Accession:
    Q8IV36
    Secondary Accessions:
    • Q8N5L6
    • Q8TE83
    • Q9NT34

    Protein attributes for HID1 Gene

    Size:
    788 amino acids
    Molecular mass:
    88745 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85070.1; Type=Frameshift; Positions=594; Evidence={ECO:0000305};

    Alternative splice isoforms for HID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HID1 Gene

Proteomics data for HID1 Gene at MOPED

Post-translational modifications for HID1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HID1 Gene

No data available for DME Specific Peptides for HID1 Gene

Domains for HID1 Gene

Protein Domains for HID1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8IV36

UniProtKB/Swiss-Prot:

HID1_HUMAN :
  • Q8IV36
Family:
  • Belongs to the hid-1 family.
genes like me logo Genes that share domains with HID1: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for HID1 Gene

Function for HID1 Gene

Molecular function for HID1 Gene

UniProtKB/Swiss-Prot Function: May play an important role in the development of cancers in a broad range of tissues.

Gene Ontology (GO) - Molecular Function for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20368287
genes like me logo Genes that share ontologies with HID1: view

Animal Model Products

miRNA for HID1 Gene

miRTarBase miRNAs that target HID1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HID1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HID1 Gene

Localization for HID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HID1 Gene

Cytoplasm. Golgi apparatus membrane; Lipid-anchor. Note=Shuttles between the cytosol and the Golgi apparatus.

Gene Ontology (GO) - Cellular Components for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000138 Golgi trans cisterna IDA 21337012
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005797 Golgi medial cisterna IDA 21337012
GO:0005881 cytoplasmic microtubule IDA 23264731
genes like me logo Genes that share ontologies with HID1: view

No data available for Subcellular locations from COMPARTMENTS for HID1 Gene

Pathways for HID1 Gene

genes like me logo Genes that share pathways with HID1: view

Pathways by source for HID1 Gene

1 BioSystems pathway for HID1 Gene
2 Reactome pathways for HID1 Gene

Gene Ontology (GO) - Biological Process for HID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IDA 21337012
GO:0031001 response to brefeldin A IDA 21337012
genes like me logo Genes that share ontologies with HID1: view

Transcripts for HID1 Gene

Unigene Clusters for HID1 Gene

HID1 domain containing:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HID1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HID1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ·
SP1: - - -
SP2:
SP3: - - - - - - -
SP4: -
SP5: - - - - - - -
SP6: - - - - -
SP7:
SP8: - - - - - -
SP9: -
SP10: - -
SP11:
SP12:
SP13:
SP14:

ExUns: 13c ^ 14a · 14b · 14c ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -

Relevant External Links for HID1 Gene

GeneLoc Exon Structure for
HID1
ECgene alternative splicing isoforms for
HID1

Expression for HID1 Gene

mRNA expression in normal human tissues for HID1 Gene

mRNA differential expression in normal tissues according to GTEx for HID1 Gene

This gene is overexpressed in Brain - Cerebellum (5.8), Brain - Cerebellar Hemisphere (5.3), and Pancreas (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HID1 Gene

SOURCE GeneReport for Unigene cluster for HID1 Gene Hs.11067

mRNA Expression by UniProt/SwissProt for HID1 Gene

Q8IV36-HID1_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines.
genes like me logo Genes that share expressions with HID1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for HID1 Gene

Orthologs for HID1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HID1 35
  • 99.2 (n)
  • 99.75 (a)
HID1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HID1 35
  • 91.95 (n)
  • 96.06 (a)
HID1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HID1 35
  • 91.73 (n)
  • 96.34 (a)
HID1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hid1 35
  • 88.87 (n)
  • 95.69 (a)
Hid1 16
Hid1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HID1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hid1 35
  • 88.75 (n)
  • 95.3 (a)
chicken
(Gallus gallus)
Aves C17ORF28 35
  • 80.75 (n)
  • 90.86 (a)
HID1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HID1 36
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24293 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hid1 35
  • 75.3 (n)
  • 82.99 (a)
MGC76040 35
zebrafish
(Danio rerio)
Actinopterygii hid1a 36
  • 74 (a)
OneToOne
hid1b 35
  • 69.01 (n)
  • 73.56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011570 35
  • 67.39 (n)
  • 69.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8841 35
  • 65.15 (n)
  • 68.48 (a)
CG8841 36
  • 62 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hid-1 35
  • 58.75 (n)
  • 60.89 (a)
hid-1 36
  • 60 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU11335 35
  • 48.85 (n)
  • 37.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ftp105 35
  • 38.73 (n)
  • 29.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 69 (a)
OneToOne
Species with no ortholog for HID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HID1 Gene

ENSEMBL:
Gene Tree for HID1 (if available)
TreeFam:
Gene Tree for HID1 (if available)

Paralogs for HID1 Gene

Selected SIMAP similar genes for HID1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HID1: view

No data available for Paralogs for HID1 Gene

Variants for HID1 Gene

Sequence variations from dbSNP and Humsavar for HID1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs902727 -- 74,959,132(+) CAAAT(C/G)CCCCC intron-variant
rs902728 -- 74,959,215(+) GGCGA(A/T)GCCTC intron-variant
rs902729 -- 74,959,428(+) CCCAT(C/T)ACCCC intron-variant
rs902730 -- 74,956,693(+) CCAGA(A/C)CACAG intron-variant
rs902731 -- 74,956,728(+) ACCAT(C/T)CTCTC intron-variant

Relevant External Links for HID1 Gene

HapMap Linkage Disequilibrium report
HID1
Human Gene Mutation Database (HGMD)
HID1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HID1 Gene

Disorders for HID1 Gene

No disorders were found for HID1 Gene.

No data available for UniProtKB/Swiss-Prot for HID1 Gene

Publications for HID1 Gene

  1. Identification of DMC1, a novel gene in the TOC region on 17q25.1 that shows loss of expression in multiple human cancers. (PMID: 11281419) Harada H. … Emi M. (J. Hum. Genet. 2001) 2 3 4 23
  2. HID-1 is a peripheral membrane protein primarily associated with the medial- and trans- Golgi apparatus. (PMID: 21337012) Wang L. … Xu T. (Protein Cell 2011) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for HID1 Gene

Sources for HID1 Gene

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