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Aliases for HIC2 Gene

Aliases for HIC2 Gene

  • HIC ZBTB Transcriptional Repressor 2 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 30 3 4
  • HIC1-Related Gene On Chromosome 22 Protein 3 4
  • ZBTB30 3 4
  • Hic-2 3 4
  • Hic-3 3 4
  • HRG22 3 4
  • Hypermethylated In Cancer 2 Protein 3
  • Hypermethylated In Cancer 2 2
  • KIAA1020 4
  • ZNF907 3

External Ids for HIC2 Gene

Previous GeneCards Identifiers for HIC2 Gene

  • GC22P018470
  • GC22P020096
  • GC22P021771
  • GC22P004831
  • GC22P021452
  • GC22P021494
  • GC22P021536
  • GC22P021836
  • GC22P021866
  • GC22P021895

Summaries for HIC2 Gene

GeneCards Summary for HIC2 Gene

HIC2 (HIC ZBTB Transcriptional Repressor 2) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is HIC1.

UniProtKB/Swiss-Prot for HIC2 Gene

  • Transcriptional repressor.

Gene Wiki entry for HIC2 Gene

Additional gene information for HIC2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIC2 Gene

Genomics for HIC2 Gene

Regulatory Elements for HIC2 Gene

Enhancers for HIC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H021814 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +399.9 399913 6.2 PKNOX1 PTBP1 BMI1 BATF SCRT2 FOS ATF7 ETV6 RUNX3 IKZF2 ENSG00000224086 LZTR1 PPM1F ENSG00000272779 IGLV5-52 ENSG00000234630 PPIL2 YPEL1 TOP3B THAP7
GH22H022036 0.9 ENCODE 5.4 +620.4 620426 1.7 HDAC1 ARNT ZNF76 TCF12 ZNF766 ZNF143 FOS ATF7 CREM ZBTB11 HIC2 IGLVI-70 ENSG00000278657 IGLV10-54 ENSG00000249333
GH22H021864 1.7 FANTOM5 ENCODE dbSUPER 2.3 +449.7 449721 4.3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ENSG00000224086 TOP3BP1 IGLV5-52 MAPK1 SDF2L1 HIC2 RNA5SP493
GH22H021876 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.9 +459.6 459581 0.9 BRD4 MAX CEBPG BMI1 BATF GATA2 EED ETV6 RUNX3 MAFK ENSG00000224086 HIC2 MAPK1 ENSG00000225544
GH22H021434 0.7 Ensembl 0.4 +18.8 18797 3.6 HDGF MNT DPF2 ZNF592 POLR2A HDAC2 NCOR1 SMARCA4 IKZF1 NR2C1 LOC105377191 HIC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HIC2 on UCSC Golden Path with GeneCards custom track

Promoters for HIC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for HIC2 Gene

Genomic Locations for HIC2 Gene
34,060 bases
Plus strand

Genomic View for HIC2 Gene

Genes around HIC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIC2 Gene

Proteins for HIC2 Gene

  • Protein details for HIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hypermethylated in cancer 2 protein
    Protein Accession:
    Secondary Accessions:
    • Q504T6
    • Q96KR3
    • Q9NSM9
    • Q9UPX9

    Protein attributes for HIC2 Gene

    615 amino acids
    Molecular mass:
    66156 Da
    Quaternary structure:
    • Self-associates. Interacts with HIC1.
    • Sequence=BAA82972.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HIC2 Gene


neXtProt entry for HIC2 Gene

Post-translational modifications for HIC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIC2 Gene

No data available for DME Specific Peptides for HIC2 Gene

Domains & Families for HIC2 Gene

Gene Families for HIC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for HIC2 Gene

Suggested Antigen Peptide Sequences for HIC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
genes like me logo Genes that share domains with HIC2: view

Function for HIC2 Gene

Molecular function for HIC2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 11554746
GO:0008022 protein C-terminus binding IPI 12052894
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HIC2: view
genes like me logo Genes that share phenotypes with HIC2: view

miRNA for HIC2 Gene

miRTarBase miRNAs that target HIC2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIC2 Gene

Localization for HIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HIC2 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11554746
genes like me logo Genes that share ontologies with HIC2: view

Pathways & Interactions for HIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated NAS 11554746
genes like me logo Genes that share ontologies with HIC2: view

No data available for Pathways by source and SIGNOR curated interactions for HIC2 Gene

Drugs & Compounds for HIC2 Gene

No Compound Related Data Available

Transcripts for HIC2 Gene

Unigene Clusters for HIC2 Gene

Hypermethylated in cancer 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIC2 Gene

No ASD Table

Relevant External Links for HIC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HIC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIC2 Gene

This gene is overexpressed in Prostate (62.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIC2 Gene

Protein tissue co-expression partners for HIC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HIC2 Gene:


SOURCE GeneReport for Unigene cluster for HIC2 Gene:


mRNA Expression by UniProt/SwissProt for HIC2 Gene:

Tissue specificity: Highest levels in cerebellum.

Evidence on tissue expression from TISSUES for HIC2 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with HIC2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HIC2 Gene

Orthologs for HIC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HIC2 33 34
  • 99.24 (n)
(Canis familiaris)
Mammalia HIC2 33 34
  • 89.89 (n)
(Rattus norvegicus)
Mammalia Hic2 33
  • 85.72 (n)
(Bos Taurus)
Mammalia HIC2 33 34
  • 85.36 (n)
(Mus musculus)
Mammalia Hic2 33 16 34
  • 85.12 (n)
(Monodelphis domestica)
Mammalia HIC2 34
  • 72 (a)
(Gallus gallus)
Aves HIC2 33 34
  • 70.22 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hic2 33
  • 67.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14683 33
(Danio rerio)
Actinopterygii hic1l 34
  • 49 (a)
hic2 33
Species where no ortholog for HIC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIC2 Gene

Gene Tree for HIC2 (if available)
Gene Tree for HIC2 (if available)

Paralogs for HIC2 Gene

Paralogs for HIC2 Gene

(14) SIMAP similar genes for HIC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIC2: view

Variants for HIC2 Gene

Sequence variations from dbSNP and Humsavar for HIC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000212880 -- 21,420,174(+) TGCTC(C/T)TGCTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000282375 -- 21,444,849(+) TCGAG(C/T)CCCAC intron-variant
rs1000414449 -- 21,420,585(+) GGGTT(A/G)GGGTT intron-variant, utr-variant-5-prime
rs1000443024 -- 21,444,587(+) ATTTA(C/G)TGTAG intron-variant
rs1000553688 -- 21,425,492(+) GCCTC(C/T)CGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIC2 Gene

Variant ID Type Subtype PubMed ID
nsv962766 CNV duplication 23825009
nsv953042 CNV deletion 24416366
nsv834145 CNV loss 17160897
nsv828965 CNV gain 20364138
nsv828963 CNV loss 20364138
nsv7350 OTHER inversion 18451855
nsv588321 CNV loss 21841781
nsv588320 CNV gain 21841781
nsv511071 OTHER inversion 20534489
nsv471596 CNV gain+loss 15918152
nsv471490 CNV gain 19718026
nsv469545 CNV gain 16826518
nsv442791 CNV gain 18776908
nsv437849 CNV loss 16327808
nsv436864 CNV insertion 17901297
nsv428386 CNV loss 18775914
nsv1160730 CNV deletion 26073780
nsv1160729 CNV duplication 26073780
nsv1118946 CNV deletion 24896259
nsv1072201 CNV deletion 25765185
nsv1066391 CNV gain 25217958
esv3893444 CNV gain 25118596
esv3584494 CNV gain 24956385
esv28075 CNV gain+loss 19812545
esv2763699 CNV gain+loss 21179565
esv2760719 CNV gain 21179565
esv2661723 CNV deletion 23128226
esv2660656 CNV deletion 23128226
dgv7996n54 CNV gain 21841781
dgv4490n100 CNV gain 25217958
dgv4489n100 CNV gain 25217958
dgv4488n100 CNV gain 25217958
dgv4487n100 CNV gain 25217958
dgv4486n100 CNV gain 25217958

Variation tolerance for HIC2 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIC2 Gene

Disorders for HIC2 Gene

Relevant External Links for HIC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HIC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIC2 Gene

Publications for HIC2 Gene

  1. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PMID: 11554746) Deltour S … Leprince D (Biochemical and biophysical research communications 2001) 2 3 4 22 60
  2. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han JW … Zhang XJ (Nature genetics 2009) 3 45 60
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D … Nagase T (DNA research : an international journal for rapid publication of reports on genes and genomes 2002) 3 4 60

Products for HIC2 Gene

Sources for HIC2 Gene

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