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Aliases for HIC2 Gene

Aliases for HIC2 Gene

  • Hypermethylated In Cancer 2 2 3
  • HRG22 3 4 6
  • Zinc Finger And BTB Domain-Containing Protein 30 3 4
  • HIC1-Related Gene On Chromosome 22 Protein 3 4
  • KIAA1020 4 6
  • ZBTB30 3 4
  • Hic-2 3 4
  • Hic-3 3 4
  • Hypermethylated In Cancer 2 Protein 3
  • ZNF907 3

External Ids for HIC2 Gene

Previous GeneCards Identifiers for HIC2 Gene

  • GC22P018470
  • GC22P020096
  • GC22P021771
  • GC22P004831

Summaries for HIC2 Gene

GeneCards Summary for HIC2 Gene

HIC2 (Hypermethylated In Cancer 2) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for HIC2 Gene

  • Transcriptional repressor

Gene Wiki entry for HIC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIC2 Gene

Genomics for HIC2 Gene

Regulatory Elements for HIC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIC2 Gene

21,417,404 bp from pter
21,451,463 bp from pter
34,060 bases
Plus strand

Genomic View for HIC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIC2 Gene

Proteins for HIC2 Gene

  • Protein details for HIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hypermethylated in cancer 2 protein
    Protein Accession:
    Secondary Accessions:
    • Q504T6
    • Q96KR3
    • Q9NSM9
    • Q9UPX9

    Protein attributes for HIC2 Gene

    615 amino acids
    Molecular mass:
    66156 Da
    Quaternary structure:
    • Self-associates. Interacts with HIC1.
    • Sequence=BAA82972.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HIC2 Gene


neXtProt entry for HIC2 Gene

Proteomics data for HIC2 Gene at MOPED

Post-translational modifications for HIC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HIC2 Gene

Domains for HIC2 Gene

Protein Domains for HIC2 Gene

Suggested Antigen Peptide Sequences for HIC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
  • Contains 5 C2H2-type zinc fingers.
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HIC2: view

Function for HIC2 Gene

Molecular function for HIC2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor

Gene Ontology (GO) - Molecular Function for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 11554746
GO:0005515 protein binding --
GO:0008022 protein C-terminus binding IPI 12052894
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HIC2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for HIC2 Gene

Localization for HIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIC2 Gene

Subcellular locations from

Jensen Localization Image for HIC2 Gene COMPARTMENTS Subcellular localization image for HIC2 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11554746
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with HIC2: view

Pathways for HIC2 Gene

SuperPathways for HIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated NAS 11554746
genes like me logo Genes that share ontologies with HIC2: view

No data available for Pathways by source for HIC2 Gene

Transcripts for HIC2 Gene

Unigene Clusters for HIC2 Gene

Hypermethylated in cancer 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HIC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIC2 Gene

No ASD Table

Relevant External Links for HIC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIC2 Gene

mRNA expression in normal human tissues for HIC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for HIC2 Gene

This gene is overexpressed in Prostate (62.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIC2 Gene

SOURCE GeneReport for Unigene cluster for HIC2 Gene Hs.632767

mRNA Expression by UniProt/SwissProt for HIC2 Gene

Tissue specificity: Highest levels in cerebellum
genes like me logo Genes that share expressions with HIC2: view

Expression partners for HIC2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for HIC2 Gene

Orthologs for HIC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HIC2 35
  • 85.36 (n)
  • 84.75 (a)
HIC2 36
  • 85 (a)
(Canis familiaris)
Mammalia HIC2 35
  • 89.89 (n)
  • 94.29 (a)
HIC2 36
  • 94 (a)
(Mus musculus)
Mammalia Hic2 35
  • 85.12 (n)
  • 88.6 (a)
Hic2 16
Hic2 36
  • 88 (a)
(Pan troglodytes)
Mammalia HIC2 35
  • 99.24 (n)
  • 99.02 (a)
HIC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hic2 35
  • 85.72 (n)
  • 89.58 (a)
(Monodelphis domestica)
Mammalia HIC2 36
  • 72 (a)
(Gallus gallus)
Aves HIC2 35
  • 70.22 (n)
  • 71.79 (a)
HIC2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hic2 35
  • 67.41 (n)
  • 69.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14683 35
(Danio rerio)
Actinopterygii hic2 35
hic1l 36
  • 49 (a)
Species with no ortholog for HIC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIC2 Gene

Gene Tree for HIC2 (if available)
Gene Tree for HIC2 (if available)

Paralogs for HIC2 Gene

(14) SIMAP similar genes for HIC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIC2: view

Variants for HIC2 Gene

Sequence variations from dbSNP and Humsavar for HIC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs12901 -- 21,451,365(-) CGTTG(A/G)TGAAT utr-variant-3-prime
rs128477 -- 21,446,155(+) GGCCA(C/T)GCCAG synonymous-codon, reference
rs131616 -- 21,421,635(-) CCTGT(G/T)CCCTC intron-variant
rs458361 -- 21,444,062(+) GTCTT(C/G)CTGCT intron-variant
rs464694 -- 21,447,200(+) GGGAA(A/C)AGGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HIC2 Gene

Variant ID Type Subtype PubMed ID
nsv436864 CNV Insertion 17901297
nsv437849 CNV Loss 16327808
esv28075 CNV Gain+Loss 19812545
nsv471490 CNV Duplication 19718026
dgv4874n71 CNV Gain 21882294
nsv914437 CNV Gain 21882294
dgv4875n71 CNV Gain 21882294
dgv4877n71 CNV Gain 21882294
nsv7350 OTHER Inversion 18451855
nsv428386 CNV Loss 18775914
nsv914448 CNV Loss 21882294
dgv4878n71 CNV Gain 21882294
nsv469545 CNV Gain 16826518
nsv471596 CNV Gain+Loss 15918152
esv2661723 CNV Deletion 23128226
nsv511071 OTHER Inversion 20534489
nsv442791 CNV CNV 18776908
dgv4879n71 CNV Loss 21882294
nsv914457 CNV Loss 21882294
nsv914458 CNV Loss 21882294
esv2660656 CNV Deletion 23128226
nsv834145 CNV Loss 17160897
nsv828963 CNV Loss 20364138
nsv828965 CNV Gain 20364138

Relevant External Links for HIC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIC2 Gene

Disorders for HIC2 Gene

Relevant External Links for HIC2

Genetic Association Database (GAD)

No disorders were found for HIC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HIC2 Gene

Publications for HIC2 Gene

  1. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PMID: 11554746) Deltour S. … Leprince D. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for HIC2 Gene

Sources for HIC2 Gene

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