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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HIC2 Gene

protein-coding   GIFtS: 53
GCID: GC22P021771

hypermethylated in cancer 2

 Explore 3 diseases affiliated with
HIC2 via our new
 Human Malady Compendium 
Biological research products
for HIC2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Hypermethylated In Cancer 21 2     HIC1-Related Gene On Chromosome 22 Protein2 3
HRG221 2 3 5     Hic-23
ZBTB301 2 3     Hic-33
KIAA10201 3 5     Hypermethylated In Cancer 2 Protein2
ZNF9071 2     Hic-23
Zinc Finger And BTB Domain-Containing Protein 302 3     Hic-33

External Ids:    HGNC: 185951   Entrez Gene: 231192   Ensembl: ENSG000001696357   OMIM: 6077125   UniProtKB: Q96JB33   

Export aliases for HIC2 gene to outside databases

Previous GC identifers: GC22P018470 GC22P020096 GC22P004831


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3
Function: Transcriptional repressor

Gene Wiki entry for HIC2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HIC2 gene promoter:
         c-Fos   AhR   AP-1   Lmo2   HNF-4alpha2   HNF-4alpha1   Arnt   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HIC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

HIC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIC2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021771:  view genomic region     (about GC identifiers)

Start:
21,771,693 bp from pter      End:
21,805,752 bp from pter
Size:
34,060 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3 (See protein sequence)
Recommended Name: Hypermethylated in cancer 2 protein  
Size: 615 amino acids; 66156 Da
Subunit: Self-associates. Interacts with HIC1
Subcellular location: Nucleus
Sequence caution: Sequence=BAA82972.2; Type=Erroneous initiation;
Secondary accessions: Q504T6 Q96KR3 Q9NSM9 Q9UPX9
Alternative splicing: 2 isoforms:  Q96JB3-1   Q96JB3-2   

Explore the universe of human proteins at neXtProt for HIC2: NX_Q96JB3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96JB3

  • HIC2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055909.2  
    ENSEMBL proteins: 
     ENSP00000385319   ENSP00000384889   ENSP00000387757  

    Human Recombinant Protein Products: 
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    Novus Biologicals HIC2 Proteins
    Novus Biologicals HIC2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HIC2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005886plasma membrane IDA--
    GO:0005925focal adhesion IDA--


    HIC2 for ontologies           About GeneDecksing



    HIC2 Antibody Products: 
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    Uscn ELISAs and CLIAs for HIC2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HIC2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q96JB3

    ProtoNet protein and cluster: Q96JB3

    1 Blocks protein family: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 C2H2-type zinc fingers


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3
    Function: Transcriptional repressor

    miRNA
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    8/185 QIAGEN miScript miRNA Assays for microRNAs that regulate HIC2 (see all 185):
    hsa-miR-411* hsa-miR-193a-3p hsa-miR-631 hsa-miR-1914* hsa-miR-146a hsa-miR-199a-3p hsa-miR-134 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIC2 (see all 7)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC2

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS11554746
    GO:0008022protein C-terminus binding IPI12052894
    GO:0008270zinc ion binding IEA--


    HIC2 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Selected targets of p53
    Selected targets of p531.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for HIC2
        Selected targets of p53




    HIC2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIC2

    5/528 Interacting proteins for HIC2 (Q96JB32, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 528)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDK2Q151192, 3MINT-64224 I2D: score=4 
    CCNT1O605633I2D: score=2 
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0045892negative regulation of transcription, DNA-dependent NAS11554746


    HIC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HIC2
    Search CenterWatch for drugs/clinical trials and news about HIC2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HIC2 gene: 
    NM_015094.2  

    Unigene Cluster for HIC2:

    Hypermethylated in cancer 2
    Hs.632767  [show with all ESTs]
    Unigene Representative Sequence: NM_015094
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407464(uc002zur.4) ENST00000407598 ENST00000443632(uc002zus.4)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HIC2
    8/185 QIAGEN miScript miRNA Assays for microRNAs that regulate HIC2 (see all 185):
    hsa-miR-411* hsa-miR-193a-3p hsa-miR-631 hsa-miR-1914* hsa-miR-146a hsa-miR-199a-3p hsa-miR-134 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIC2 (see all 7)
    OriGene shRNA RFP: HIC2
    OriGene siRNA: HIC2
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIC2
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    Additional cDNA sequence: 

    AB028943.2 AF349035.2 AJ313204.1 AK023021.1 AL162003.1 BC009207.2 BC009216.2 BC094787.1 
    CR456377.1 

    4 DOTS entries:

    DT.100672251  DT.444722  DT.91907241  DT.100677620 

    24/154 AceView cDNA sequences (see all 154):

    AW474732 AI273282 AI061283 BM714562 AW295784 CK822868 AI632164 AI521209 
    AI912206 BF439025 BM675330 AI963940 BQ102257 BG335239 NM_015094 BE219393 
    BE045419 CR625262 AA369408 BQ025783 BU731107 BF110502 BE465318 BM722435 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HIC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGGAAAGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    HIC2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryAntral FollicleSecondary OocyteFemale Gametocytes, Germ Cells
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HIC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HIC2

    SOURCE GeneReport for Unigene cluster: Hs.632767

    UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3
    Tissue specificity: Highest levels in cerebellum

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HIC2 gene from 3/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HIC21 hypermethylated in cancer 2 70.56(n)
    72.3(a)
      416768  XM_001232816.2  XP_001232817.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146832 Xenopus laevis transcribed sequence with moderate similarity more 76.88(n)    BJ620277.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hic22 hypermethylated in cancer 2 78.86(n)   359828  AJ307688.1 


    ENSEMBL Gene Tree for HIC2 (if available)
    TreeFam Gene Tree for HIC2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HIC2 gene
    ZBTB102  ZBTB32  ZBTB182  ZBTB8A2  ENSG000002545532  ZBTB442  ZBTB52  ZBTB492  
    HIC12  ZBTB242  MYNN2  GZF12  ZBTB422  ZBTB462  ZBTB8B2  ZBTB172  
    14 SIMAP similar genes for HIC2 using alignment to 1 protein entry:     HIC2_HUMAN:
    PLZF    ZNF137P    ZNF    HIC1    ZNF697    ZNF702P
    ZFP41    ZNF581    ZNF501    ZNF664    ZNF32    ZNF833P
    ZNF323    ZNF808

    HIC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/222 NCBI SNPs in HIC2 are shown (see all 222    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10585491,2
    F--4830072(+) GGCTTG/AGTAAC 3 -- int1 nc-transcript-variant1Minor allele frequency- A:0.10MN 184
    rs10585571,2
    F--4830081(+) ACGCCA/GTGGAC 3 -- nc-transcript-variantint11Minor allele frequency- G:0.29MN 184
    rs10585681,2
    F--4830101(+) AATCAA/GTGGAT 3 -- int1 nc-transcript-variant1Minor allele frequency- G:0.11MN 184
    rs1503579491,2
    --21775665(+) GGAGGA/CGAGGC 1 -- int10--------
    rs1380807831,2
    --21775666(+) GAGGCA/GAGGCT 1 -- int10--------
    rs1148440771,2
    F,--21775942(+) CAGCTA/TGGTGC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1833532081,2
    --21775947(+) AGGTGC/TCTCTT 1 -- int10--------
    rs1996665781,2
    --21775947(+) AGGTG-/CCTCTT 1 -- int10--------
    rs1883737291,2
    --21786293(+) CCGAAC/TGTATA 1 -- int10--------
    rs1509896261,2
    --21787200(+) GTGTTG/TTTGTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HIC2 (21771693 - 21805752 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for HIC2
         10 CNVs: 73765 5173 73764 2263 90900 79463 0817 79461 90898 38956
         1 Indel: 73762

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HIC2 for disorders           About GeneDecksing

    OMIM gene information: 607712    OMIM disorders: --

    3 diseases for HIC2:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus    digeorge syndrome


    Export disorders for HIC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HIC2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with HIC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PubMed id 11554746)1, 2, 3, 9 Deltour S.... Leprince D. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    5. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    7. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    10. Genome-wide association study in a Chinese Han popula tion identifies nine new susceptibility loci for systemic lupus erythematosus. (PubMed id 19838193)1 Han J.W....Zhang X.J. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23119 HGNC: 18595 AceView: HIC2 Ensembl:ENSG00000169635 euGenes: HUgn23119
    ECgene: HIC2 H-InvDB: HIC2

    (According to HUGE)
    About This Section
    HUGE: KIAA1020

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HIC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HIC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HIC2 gene:
    Search GeneIP for patents involving HIC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
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