Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HIC2 Gene

Aliases for HIC2 Gene

  • Hypermethylated In Cancer 2 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 30 3 4
  • HIC1-Related Gene On Chromosome 22 Protein 3 4
  • ZBTB30 3 4
  • Hic-2 3 4
  • Hic-3 3 4
  • HRG22 3 4
  • KIAA1020 4
  • ZNF907 3

External Ids for HIC2 Gene

Previous GeneCards Identifiers for HIC2 Gene

  • GC22P018470
  • GC22P020096
  • GC22P021771
  • GC22P004831
  • GC22P021452
  • GC22P021494

Summaries for HIC2 Gene

GeneCards Summary for HIC2 Gene

HIC2 (Hypermethylated In Cancer 2) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is ENSG00000254553.

UniProtKB/Swiss-Prot for HIC2 Gene

  • Transcriptional repressor.

Gene Wiki entry for HIC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIC2 Gene

Genomics for HIC2 Gene

Regulatory Elements for HIC2 Gene

Enhancers for HIC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HIC2 on UCSC Golden Path with GeneCards custom track

Promoters for HIC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HIC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for HIC2 Gene

21,417,404 bp from pter
21,451,463 bp from pter
34,060 bases
Plus strand

Genomic View for HIC2 Gene

Genes around HIC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIC2 Gene

Proteins for HIC2 Gene

  • Protein details for HIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hypermethylated in cancer 2 protein
    Protein Accession:
    Secondary Accessions:
    • Q504T6
    • Q96KR3
    • Q9NSM9
    • Q9UPX9

    Protein attributes for HIC2 Gene

    615 amino acids
    Molecular mass:
    66156 Da
    Quaternary structure:
    • Self-associates. Interacts with HIC1.
    • Sequence=BAA82972.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HIC2 Gene


neXtProt entry for HIC2 Gene

Proteomics data for HIC2 Gene at MOPED

Post-translational modifications for HIC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HIC2 Gene

Domains & Families for HIC2 Gene

Gene Families for HIC2 Gene

Protein Domains for HIC2 Gene

Suggested Antigen Peptide Sequences for HIC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
  • Contains 5 C2H2-type zinc fingers.
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HIC2: view

Function for HIC2 Gene

Molecular function for HIC2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with HIC2: view
genes like me logo Genes that share phenotypes with HIC2: view

Animal Model Products

miRNA for HIC2 Gene

miRTarBase miRNAs that target HIC2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIC2 Gene

Localization for HIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIC2 Gene

Subcellular locations from

Jensen Localization Image for HIC2 Gene COMPARTMENTS Subcellular localization image for HIC2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for HIC2 Gene

Pathways & Interactions for HIC2 Gene

SuperPathways for HIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated NAS 11554746
genes like me logo Genes that share ontologies with HIC2: view

No data available for Pathways by source and SIGNOR curated interactions for HIC2 Gene

Drugs & Compounds for HIC2 Gene

No Compound Related Data Available

Transcripts for HIC2 Gene

Unigene Clusters for HIC2 Gene

Hypermethylated in cancer 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HIC2 Gene

No ASD Table

Relevant External Links for HIC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HIC2 Gene

mRNA expression in normal human tissues for HIC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIC2 Gene

This gene is overexpressed in Prostate (62.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HIC2 Gene

SOURCE GeneReport for Unigene cluster for HIC2 Gene Hs.632767

mRNA Expression by UniProt/SwissProt for HIC2 Gene

Tissue specificity: Highest levels in cerebellum.
genes like me logo Genes that share expression patterns with HIC2: view

Protein tissue co-expression partners for HIC2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for HIC2 Gene

Orthologs for HIC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HIC2 35
  • 85.36 (n)
  • 84.75 (a)
HIC2 36
  • 85 (a)
(Canis familiaris)
Mammalia HIC2 35
  • 89.89 (n)
  • 94.29 (a)
HIC2 36
  • 94 (a)
(Mus musculus)
Mammalia Hic2 35
  • 85.12 (n)
  • 88.6 (a)
Hic2 16
Hic2 36
  • 88 (a)
(Pan troglodytes)
Mammalia HIC2 35
  • 99.24 (n)
  • 99.02 (a)
HIC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hic2 35
  • 85.72 (n)
  • 89.58 (a)
(Monodelphis domestica)
Mammalia HIC2 36
  • 72 (a)
(Gallus gallus)
Aves HIC2 35
  • 70.22 (n)
  • 71.79 (a)
HIC2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hic2 35
  • 67.41 (n)
  • 69.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14683 35
(Danio rerio)
Actinopterygii hic2 35
hic1l 36
  • 49 (a)
Species with no ortholog for HIC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIC2 Gene

Gene Tree for HIC2 (if available)
Gene Tree for HIC2 (if available)

Paralogs for HIC2 Gene

(14) SIMAP similar genes for HIC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIC2: view

Variants for HIC2 Gene

Sequence variations from dbSNP and Humsavar for HIC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs12901 -- 21,451,365(+) CGTTG(A/C/G/T)TGAAT utr-variant-3-prime
rs128477 -- 21,446,155(+) GGCCA(C/T)GCCAG reference, synonymous-codon
rs2287409 -- 21,448,883(+) CCTGA(C/T)GCCAC utr-variant-3-prime
rs140481 -- 21,419,754(-) TAATC(C/T)GCGAC intron-variant, upstream-variant-2KB
rs34266331 -- 21,451,290(-) AAGGG(-/T)ACATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HIC2 Gene

Variant ID Type Subtype PubMed ID
nsv436864 CNV Insertion 17901297
nsv437849 CNV Loss 16327808
esv28075 CNV Gain+Loss 19812545
nsv471490 CNV Duplication 19718026
dgv4874n71 CNV Gain 21882294
nsv914437 CNV Gain 21882294
dgv4875n71 CNV Gain 21882294
dgv4877n71 CNV Gain 21882294
nsv7350 OTHER Inversion 18451855
nsv428386 CNV Loss 18775914
nsv914448 CNV Loss 21882294
dgv4878n71 CNV Gain 21882294
nsv469545 CNV Gain 16826518
nsv471596 CNV Gain+Loss 15918152
esv2661723 CNV Deletion 23128226
nsv511071 OTHER Inversion 20534489
nsv442791 CNV CNV 18776908
dgv4879n71 CNV Loss 21882294
nsv914457 CNV Loss 21882294
nsv914458 CNV Loss 21882294
esv2660656 CNV Deletion 23128226
nsv834145 CNV Loss 17160897
nsv828963 CNV Loss 20364138
nsv828965 CNV Gain 20364138

Variation tolerance for HIC2 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.24% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HIC2 Gene

Disorders for HIC2 Gene

Relevant External Links for HIC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HIC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIC2 Gene

Publications for HIC2 Gene

  1. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PMID: 11554746) Deltour S. … Leprince D. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. (PMID: 24748541) Dykes I.M. … Scambler P.J. (Circ. Res. 2014) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for HIC2 Gene

Sources for HIC2 Gene