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Aliases for HIC2 Gene

Aliases for HIC2 Gene

  • HIC ZBTB Transcriptional Repressor 2 2 3 5
  • Zinc Finger And BTB Domain-Containing Protein 30 3 4
  • HIC1-Related Gene On Chromosome 22 Protein 3 4
  • ZBTB30 3 4
  • Hic-2 3 4
  • Hic-3 3 4
  • HRG22 3 4
  • Hypermethylated In Cancer 2 Protein 3
  • Hypermethylated In Cancer 2 2
  • KIAA1020 4
  • ZNF907 3

External Ids for HIC2 Gene

Previous GeneCards Identifiers for HIC2 Gene

  • GC22P018470
  • GC22P020096
  • GC22P021771
  • GC22P004831
  • GC22P021452
  • GC22P021494
  • GC22P021536
  • GC22P021836

Summaries for HIC2 Gene

GeneCards Summary for HIC2 Gene

HIC2 (HIC ZBTB Transcriptional Repressor 2) is a Protein Coding gene. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is HIC1.

UniProtKB/Swiss-Prot for HIC2 Gene

  • Transcriptional repressor.

Gene Wiki entry for HIC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIC2 Gene

Genomics for HIC2 Gene

Regulatory Elements for HIC2 Gene

Enhancers for HIC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F021813 1.5 FANTOM5 Ensembl ENCODE 5.5 +399.7 399697 7.4 PKNOX1 ARNT CREB3L1 SIN3A CBX5 GATA2 ZNF207 FOS KLF13 KDM4B ENSG00000224086 PPM1F IGLV5-52 YPEL1 THAP7-AS1 THAP7 ENSG00000272779 TOP3BP1 MAPK1 HIC2
GH22F022036 1.1 Ensembl ENCODE 5.4 +620.4 620426 1.7 HDAC1 ARNT TBL1XR1 ZNF76 ZNF143 FOS CREM ZBTB11 CEBPB ZNF589 HIC2 IGLVI-70 ENSG00000249333 ENSG00000278657
GH22F021864 1.3 FANTOM5 ENCODE 2.3 +449.7 449721 4.3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 ENSG00000224086 TOP3BP1 IGLV5-52 MAPK1 SDF2L1 HIC2 RNA5SP493
GH22F021876 0.8 FANTOM5 Ensembl ENCODE 1.9 +459.4 459423 1.3 BRD4 PKNOX1 USF1 TBL1XR1 MAX BMI1 GATA2 NFYB EED ETV6 ENSG00000224086 HIC2 MAPK1 ENSG00000225544
GH22F021407 0.5 Ensembl 0.4 -9.5 -9504 0.2 HIC2 ENSG00000275840
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HIC2 on UCSC Golden Path with GeneCards custom track

Promoters for HIC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001842096 96 2201 SCRT1 HDAC1 PKNOX1 KLF1 TBL1XR1 HLF BHLHE40 NR4A1 TSC22D4 ZBTB7A

Genomic Location for HIC2 Gene

Chromosome:
22
Start:
21,417,404 bp from pter
End:
21,451,463 bp from pter
Size:
34,060 bases
Orientation:
Plus strand

Genomic View for HIC2 Gene

Genes around HIC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HIC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIC2 Gene

Proteins for HIC2 Gene

  • Protein details for HIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JB3-HIC2_HUMAN
    Recommended name:
    Hypermethylated in cancer 2 protein
    Protein Accession:
    Q96JB3
    Secondary Accessions:
    • Q504T6
    • Q96KR3
    • Q9NSM9
    • Q9UPX9

    Protein attributes for HIC2 Gene

    Size:
    615 amino acids
    Molecular mass:
    66156 Da
    Quaternary structure:
    • Self-associates. Interacts with HIC1.
    SequenceCaution:
    • Sequence=BAA82972.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HIC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIC2 Gene

Post-translational modifications for HIC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HIC2 Gene

No data available for DME Specific Peptides for HIC2 Gene

Domains & Families for HIC2 Gene

Gene Families for HIC2 Gene

Suggested Antigen Peptide Sequences for HIC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JB3

UniProtKB/Swiss-Prot:

HIC2_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
  • Contains 5 C2H2-type zinc fingers.
Domain:
  • Contains 1 BTB (POZ) domain.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
Similarity:
  • Contains 5 C2H2-type zinc fingers.
genes like me logo Genes that share domains with HIC2: view

Function for HIC2 Gene

Molecular function for HIC2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Gene Ontology (GO) - Molecular Function for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 11554746
GO:0008022 protein C-terminus binding IPI 12052894
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with HIC2: view
genes like me logo Genes that share phenotypes with HIC2: view

Animal Model Products

miRNA for HIC2 Gene

miRTarBase miRNAs that target HIC2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HIC2 Gene

Localization for HIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIC2 Gene COMPARTMENTS Subcellular localization image for HIC2 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11554746
genes like me logo Genes that share ontologies with HIC2: view

Pathways & Interactions for HIC2 Gene

SuperPathways for HIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated NAS 11554746
genes like me logo Genes that share ontologies with HIC2: view

No data available for Pathways by source and SIGNOR curated interactions for HIC2 Gene

Transcripts for HIC2 Gene

Unigene Clusters for HIC2 Gene

Hypermethylated in cancer 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIC2 Gene

No ASD Table

Relevant External Links for HIC2 Gene

GeneLoc Exon Structure for
HIC2
ECgene alternative splicing isoforms for
HIC2

Expression for HIC2 Gene

mRNA expression in normal human tissues for HIC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HIC2 Gene

This gene is overexpressed in Prostate (62.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HIC2 Gene



Protein tissue co-expression partners for HIC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of HIC2 Gene:

HIC2

SOURCE GeneReport for Unigene cluster for HIC2 Gene:

Hs.632767

mRNA Expression by UniProt/SwissProt for HIC2 Gene:

Q96JB3-HIC2_HUMAN
Tissue specificity: Highest levels in cerebellum.
genes like me logo Genes that share expression patterns with HIC2: view

Primer Products

No data available for mRNA differential expression in normal tissues for HIC2 Gene

Orthologs for HIC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HIC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIC2 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia HIC2 34 35
  • 89.89 (n)
rat
(Rattus norvegicus)
Mammalia Hic2 34
  • 85.72 (n)
cow
(Bos Taurus)
Mammalia HIC2 34 35
  • 85.36 (n)
mouse
(Mus musculus)
Mammalia Hic2 34 16 35
  • 85.12 (n)
oppossum
(Monodelphis domestica)
Mammalia HIC2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves HIC2 34 35
  • 70.22 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia hic2 34
  • 67.41 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14683 34
zebrafish
(Danio rerio)
Actinopterygii hic1l 35
  • 49 (a)
OneToOne
hic2 34
Species where no ortholog for HIC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HIC2 Gene

ENSEMBL:
Gene Tree for HIC2 (if available)
TreeFam:
Gene Tree for HIC2 (if available)

Paralogs for HIC2 Gene

(14) SIMAP similar genes for HIC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HIC2: view

Variants for HIC2 Gene

Sequence variations from dbSNP and Humsavar for HIC2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10597644 -- 21,447,265(+) TGGGA(-/CAGT)CAGGG utr-variant-3-prime
rs111480484 -- 21,449,074(+) ACGAC(A/G)TTTGT utr-variant-3-prime
rs111559563 -- 21,438,447(+) CCTCC(C/T)CTCTC intron-variant
rs111571475 -- 21,443,106(+) GGGGC(A/C)AAGTG intron-variant
rs111983635 -- 21,430,735(+) TGTGG(G/T)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIC2 Gene

Variant ID Type Subtype PubMed ID
dgv4486n100 CNV gain 25217958
dgv4487n100 CNV gain 25217958
dgv4488n100 CNV gain 25217958
dgv4489n100 CNV gain 25217958
dgv4490n100 CNV gain 25217958
dgv7996n54 CNV gain 21841781
esv2660656 CNV deletion 23128226
esv2661723 CNV deletion 23128226
esv2760719 CNV gain 21179565
esv2763699 CNV gain+loss 21179565
esv28075 CNV gain+loss 19812545
esv3584494 CNV gain 24956385
esv3893444 CNV gain 25118596
nsv1066391 CNV gain 25217958
nsv1072201 CNV deletion 25765185
nsv1118946 CNV deletion 24896259
nsv1160729 CNV duplication 26073780
nsv1160730 CNV deletion 26073780
nsv428386 CNV loss 18775914
nsv436864 CNV insertion 17901297
nsv437849 CNV loss 16327808
nsv442791 CNV gain 18776908
nsv469545 CNV gain 16826518
nsv471490 CNV gain 19718026
nsv471596 CNV gain+loss 15918152
nsv511071 OTHER inversion 20534489
nsv588320 CNV gain 21841781
nsv588321 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv828963 CNV loss 20364138
nsv828965 CNV gain 20364138
nsv834145 CNV loss 17160897
nsv953042 CNV deletion 24416366
nsv962766 CNV duplication 23825009

Variation tolerance for HIC2 Gene

Residual Variation Intolerance Score: 17.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.95; 49.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HIC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HIC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIC2 Gene

Disorders for HIC2 Gene

Relevant External Links for HIC2

Genetic Association Database (GAD)
HIC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HIC2

No disorders were found for HIC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HIC2 Gene

Publications for HIC2 Gene

  1. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PMID: 11554746) Deltour S. … Leprince D. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 22 64
  2. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han J.W. … Zhang X.J. (Nat. Genet. 2009) 3 46 64
  3. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64

Products for HIC2 Gene

Sources for HIC2 Gene

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