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HIC2 Gene

protein-coding   GIFtS: 54
GCID: GC22P021771

Hypermethylated In Cancer 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hypermethylated In Cancer 21 2     ZNF9072
HRG222 3 5     hic-22
Zinc Finger And BTB Domain-Containing Protein 302 3     hic-32
ZBTB302 3     Hypermethylated In Cancer 2 Protein2
HIC1-Related Gene On Chromosome 22 Protein2 3     Hic-23
KIAA10203 5     Hic-33

External Ids:    HGNC: 185951   Entrez Gene: 231192   Ensembl: ENSG000001696357   OMIM: 6077125   UniProtKB: Q96JB33   

Export aliases for HIC2 gene to outside databases

Previous GC identifers: GC22P018470 GC22P020096 GC22P004831


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for HIC2 Gene:
HIC2 (hypermethylated in cancer 2) is a protein-coding gene. Diseases associated with HIC2 include digeorge syndrome, and systemic lupus erythematosus. GO annotations related to this gene include protein C-terminus binding. An important paralog of this gene is ZBTB10.

UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3
Function: Transcriptional repressor

Gene Wiki entry for HIC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIC2 gene promoter:
         c-Fos   AhR   AP-1   Lmo2   HNF-4alpha2   HNF-4alpha1   Arnt   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHIC2 promoter sequence
   Search Chromatin IP Primers for HIC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

HIC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIC2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021771:  view genomic region     (about GC identifiers)

Start:
21,771,693 bp from pter      End:
21,805,752 bp from pter
Size:
34,060 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3 (See protein sequence)
Recommended Name: Hypermethylated in cancer 2 protein  
Size: 615 amino acids; 66156 Da
Subunit: Self-associates. Interacts with HIC1
Sequence caution: Sequence=BAA82972.2; Type=Erroneous initiation;
Secondary accessions: Q504T6 Q96KR3 Q9NSM9 Q9UPX9
Alternative splicing: 2 isoforms:  Q96JB3-1   Q96JB3-2   

Explore the universe of human proteins at neXtProt for HIC2: NX_Q96JB3

Explore proteomics data for HIC2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055909.2  
    ENSEMBL proteins: 
     ENSP00000385319   ENSP00000384889   ENSP00000387757  

    HIC2 Human Recombinant Protein Products:

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    Novus Biologicals HIC2 Proteins
    Novus Biologicals HIC2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for HIC2

    HIC2 Antibody Products:

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    Abcam antibodies for HIC2
    Cloud-Clone Corp. Antibodies for HIC2
    Search ThermoFisher Antibodies for HIC2
    LSBio Antibodies in human, mouse, rat for HIC2

    HIC2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for HIC2
    Cloud-Clone Corp. CLIAs for HIC2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 6):
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ

    Graphical View of Domain Structure for InterPro Entry Q96JB3

    ProtoNet protein and cluster: Q96JB3

    1 Blocks protein domain: IPB000210 BTB/POZ domain

    UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 C2H2-type zinc fingers


    HIC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HIC2_HUMAN, Q96JB3
    Function: Transcriptional repressor

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding NAS11554746
    GO:0005515protein binding ----
    GO:0008022protein C-terminus binding IPI12052894
    GO:0046872metal ion binding IEA--
         
    HIC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIC2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIC2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIC2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIC2:
    hsa-mir-769-5p (MIRT016094), hsa-mir-484 (MIRT042187), hsa-mir-30b-5p (MIRT023435), hsa-mir-378a-3p (MIRT043900), hsa-mir-28-3p (MIRT038944), hsa-mir-24-3p (MIRT030600)

    Block miRNA regulation of human, mouse, rat HIC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIC2 (see all 185):
    hsa-miR-411* hsa-miR-193a-3p hsa-miR-631 hsa-miR-1914* hsa-miR-146a hsa-miR-199a-3p hsa-miR-134 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HIC2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: HIC2 (NM_015094)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIC2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for HIC2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HIC2_HUMAN, Q96JB3: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005886plasma membrane IDA--
    GO:0005925focal adhesion ----

    HIC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIC2 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of p53
    Selected targets of p53



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HIC2
    Interactions:

        GeneGlobe Interaction Network for HIC2

    Selected Interacting proteins for HIC2 (Q96JB32, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 555)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDK2Q151192, 3MINT-64224 I2D: score=4 
    CCNT1O605633I2D: score=2 
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    ACTBP607092MINT-7947479
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0045892negative regulation of transcription, DNA-templated NAS11554746

    HIC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HIC2 gene: 
    NM_015094.2  

    Unigene Cluster for HIC2:

    Hypermethylated in cancer 2
    Hs.632767  [show with all ESTs]
    Unigene Representative Sequence: NM_015094
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000407464(uc002zur.4) ENST00000407598 ENST00000443632(uc002zus.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HIC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIC2 (see all 185):
    hsa-miR-411* hsa-miR-193a-3p hsa-miR-631 hsa-miR-1914* hsa-miR-146a hsa-miR-199a-3p hsa-miR-134 hsa-miR-3921
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HIC2
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    OriGene clones in human, mouse for HIC2 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HIC2 (NM_015094)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIC2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIC2
    Primer
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    OriGene qPCR primer pairs and template standards for HIC2
    OriGene qSTAR qPCR primer pairs in human, mouse for HIC2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIC2
      QuantiTect SYBR Green Assays in human, mouse, rat HIC2
      QuantiFast Probe-based Assays in human, mouse, rat HIC2

    Additional mRNA sequence: 

    AB028943.2 AF349035.2 AJ313204.1 AK023021.1 AL162003.1 BC009207.2 BC009216.2 BC094787.1 
    CR456377.1 

    4 DOTS entries:

    DT.100672251  DT.444722  DT.91907241  DT.100677620 

    Selected AceView cDNA sequences (see all 154):

    BM722435 CK822868 AI830051 AW295784 CA444832 BU727282 AW274991 AI521209 
    BQ086142 AW594591 AI963940 BG235960 BM678958 AI273282 CR625262 AI056611 
    CA433635 BF439025 BF110502 AI912206 AW474732 AI632164 BM714562 BG335239 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGAAAGAG
    HIC2 Expression
    About this image


    HIC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Placenta (Extraembryonic Tissues)
    HIC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632767

    UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3
    Tissue specificity: Highest levels in cerebellum

        Custom PCR Arrays for HIC2
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    QuantiFast Probe-based Assays in human, mouse, rat HIC2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIC2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hic21 , 5 hypermethylated in cancer 21, 5 85.12(n)1
    88.6(a)1
      16 (10.68 cM)5
    581801  NM_178922.31  NP_849253.21 
     172335725 
    chicken
    (Gallus gallus)
    Aves HIC21 hypermethylated in cancer 2 70.22(n)
    71.79(a)
      416768  NM_001277483.1  NP_001264412.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.146832 Xenopus laevis transcribed sequence with moderate similarity more 76.88(n)    BJ620277.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hic22 hypermethylated in cancer 2 78.86(n)   359828  AJ307688.1 


    ENSEMBL Gene Tree for HIC2 (if available)
    TreeFam Gene Tree for HIC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIC2 gene
    ZBTB102  ZBTB32  ZBTB182  ZBTB8A2  ZBTB442  ZBTB52  ENSG000002545532  ZBTB492  
    HIC12  ZBTB482  MYNN2  ZBTB422  ZBTB462  ZBTB8B2  ZBTB172  
    14 SIMAP similar genes for HIC2 using alignment to 1 protein entry:     HIC2_HUMAN:
    PLZF    ZNF137P    ZNF    HIC1    ZNF697    ZNF702P
    ZFP41    ZNF581    ZNF501    ZNF664    ZNF32    ZNF833P
    ZNF323    ZNF808

    HIC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIC2 (see all 289)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503579491,2
    C--21775665(+) GGAGGA/CGAGGC 1 -- int10--------
    rs1380807831,2
    C--21775666(+) GAGGCA/GAGGCT 1 -- int10--------
    rs1148440771,2
    F--21775942(+) CAGCTA/TGGTGC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1833532081,2
    --21775947(+) AGGTGC/TCTCTT 1 -- int10--------
    rs1996665781,2
    --21775947(+) AGGTG-/CCTCTT 1 -- int10--------
    rs1883737291,2
    --21786293(+) CCGAAC/TGTATA 1 -- int10--------
    rs1509896261,2
    C--21787200(+) GTGTTG/TTTGTT 1 -- int10--------
    rs1916679321,2
    C--21788779(+) GTCAGA/GCGGTG 1 -- int10--------
    rs1383940541,2
    C--21792469(+) CAGGGG/TTATCA 1 -- int10--------
    rs1379767001,2
    C--21792691(+) AGTTTC/TCTGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for HIC2 (21771693 - 21805752 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HIC2 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660656CNV Deletion23128226
    esv2661723CNV Deletion23128226
    nsv471490CNV Duplication19718026
    nsv436864CNV Insertion17901297
    nsv914448CNV Loss21882294
    nsv914458CNV Loss21882294
    nsv428386CNV Loss18775914
    nsv834145CNV Loss17160897
    nsv437849CNV Loss16327808
    nsv828963CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIC2
    DNA2.0 Custom Variant and Variant Library Synthesis for HIC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607712    OMIM disorders: --

    3 diseases for HIC2:    
    About MalaCards
    digeorge syndrome    systemic lupus erythematosus    lupus erythematosus


    HIC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HIC2

    Export disorders for HIC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIC2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with HIC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PubMed id 11554746)1, 2, 3, 9 Deltour S.... Leprince D. (Biochem. Biophys. Res. Commun. 2001)
    2. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PubMed id 19838193)1, 4 Han J.W....Zhang X.J. (Nat. Genet. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    7. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23119 HGNC: 18595 AceView: HIC2 Ensembl:ENSG00000169635 euGenes: HUgn23119
    ECgene: HIC2 H-InvDB: HIC2

    (According to HUGE)
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    HUGE: KIAA1020

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HIC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIC2 gene:
    Search GeneIP for patents involving HIC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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