HIC2 Gene
protein-coding GIFtS : 53
GCID: GC22 P021771
hypermethylated in cancer 2
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Aliasesfor HIC2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Hypermethylated In Cancer 2 1 2 HIC1-Related Gene On Chromosome 22 Protein2 3 HRG221 2 3 5 Hic-23 ZBTB301 2 3 Hic-33 KIAA10201 3 5 Hypermethylated In Cancer 2 Protein2 ZNF9071 2 Hic-23 Zinc Finger And BTB Domain-Containing Protein 302 3 Hic-33
Export aliases for HIC2 gene to outside databases Previous GC identifers: GC22P018470 GC22P020096 GC22P004831
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Summariesfor HIC2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3 Function : Transcriptional repressorGene Wiki entry for HIC2
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Genomic Viewsfor HIC2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000022.10 NC_018933.1 NT_011520.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HIC2 gene promoter: c-Fos AhR AP-1 Lmo2 HNF-4alpha2 HNF-4alpha1 Arnt POU2F1 POU2F1a c-Jun Other transcription factors Search SABiosciences Chromatin IP Primers for HIC2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat HIC2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21 HIC2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 22 GeneLoc Exon Structure
GeneLoc location for GC22P021771: view genomic region
(about GC identifiers )
Start:
21,771,693 bp from pter
End:
21,805,752 bp from pter
Size:
34,060 bases
Orientation:
plus strand
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Proteinsfor HIC2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3 (See
protein sequence )Recommended Name: Hypermethylated in cancer 2 protein Size : 615 amino acids; 66156 Da
Subunit : Self-associates. Interacts with HIC1
Subcellular location : Nucleus
Sequence caution : Sequence=BAA82972.2; Type=Erroneous initiation;
Secondary accessions : Q504T6 Q96KR3 Q9NSM9 Q9UPX9Alternative splicing : 2 isoforms : Q96JB3-1 Q96JB3-2 Explore the universe of human proteins at neXtProt for HIC2: NX_Q96JB3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q96JB3 HIC2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_055909.2 ENSEMBL proteins: ENSP00000385319 ENSP00000384889 ENSP00000387757 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
HIC2 for ontologies About GeneDecksing HIC2 Antibody Products: Assay Products for HIC2:
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Protein
Domains / Familiesfor HIC2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
HIC2 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q96JB3 ProtoNet protein and cluster: Q96JB3
1 Blocks protein family : IPB000210 BTB/POZ domain UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3 Similarity : Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamilySimilarity : Contains 1 BTB (POZ) domainSimilarity : Contains 5 C2H2-type zinc fingers
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Functionfor HIC2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3 Function : Transcriptional repressor
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HIC2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HIC2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: HIC2 (NM_015094 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIC2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HIC2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
HIC2 for ontologies About GeneDecksing
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Pathways & Interactionsfor HIC2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Selected targets of p53
Pathway sources See GeneCards unified pathways Show all pathways 1 EMD Millipore Pathway for HIC2
HIC2 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIC2 5/528 Interacting proteins for HIC2 (Q96JB3 2 , 3 ) via UniProtKB, MINT, STRING, and/or I2D (see all 528 )About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006351 transcription, DNA-dependent
IEA -- GO:0045892 negative regulation of transcription, DNA-dependent
NAS 11554746
HIC2 for ontologies About GeneDecksing
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Drugs & Compoundsfor HIC2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for HIC2 Search CenterWatch for drugs/clinical trials and news about HIC2
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Transcriptsfor HIC2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for HIC2 gene: NM_015094.2 Unigene Cluster for HIC2:
Hypermethylated in cancer 2 Hs.632767 [show with all ESTs ] Unigene Representative Sequence: NM_015094 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000407464 (uc002zur.4 ) ENST00000407598 ENST00000443632 (uc002zus.4 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HIC2 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HIC2OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: HIC2 (NM_015094 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIC2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HIC2
Additional cDNA sequence: AB028943.2 AF349035.2 AJ313204.1 AK023021.1 AL162003.1 BC009207.2 BC009216.2 BC094787.1 CR456377.1
4 DOTS entries : DT.100672251 DT.444722
DT.91907241 DT.100677620 24/154 AceView cDNA sequences (see all 154 ):
AW474732 AI273282 AI061283 BM714562 AW295784 CK822868 AI632164 AI521209 AI912206 BF439025 BM675330 AI963940 BQ102257 BG335239 NM_015094 BE219393 BE045419 CR625262 AA369408 BQ025783 BU731107 BF110502 BE465318 BM722435 GeneLoc Exon Structure
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Expression for HIC2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section HIC2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAGGAAAGAG
About this image HIC2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Ovary Antral Follicle Secondary Oocyte Female Gametocytes, Germ Cells Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See HIC2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HIC2 SOURCE GeneReport for Unigene cluster: Hs.632767 UniProtKB/Swiss-Prot: HIC2_HUMAN, Q96JB3 Tissue specificity : Highest levels in cerebellum SABiosciences Custom PCR Arrays for HIC2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for HIC2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat HIC2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat HIC2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat HIC2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC2
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Orthologsfor HIC2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for HIC2 gene from 3/10 species (see all 10 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
HIC21
hypermethylated in cancer 2
70.56(n) 72.3(a)
 
416768 XM_001232816.2 XP_001232817.1
African clawed frog (Xenopus laevis)
Amphibia
Xl.146832
Xenopus laevis transcribed sequence with moderate similarity more
76.88(n)
 
BJ620277.1
zebrafish (Danio rerio)
Actinopterygii
hic22
hypermethylated in cancer 2
78.86(n)
 
359828 AJ307688.1
ENSEMBL Gene Tree for HIC2 (if available)TreeFam Gene Tree for HIC2 (if available)
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Paralogsfor HIC2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for HIC2 gene ZBTB10 2 ZBTB3 2 ZBTB18 2 ZBTB8A 2 ENSG00000254553 2 ZBTB44 2 ZBTB5 2 ZBTB49 2 HIC1 2 ZBTB24 2 MYNN 2 GZF1 2 ZBTB42 2 ZBTB46 2 ZBTB8B 2 ZBTB17 2 14 SIMAP similar genes for HIC2 using alignment to 1 protein entry: HIC2_HUMAN :PLZF ZNF137P ZNF HIC1 ZNF697 ZNF702P ZFP41 ZNF581 ZNF501 ZNF664 ZNF32 ZNF833P ZNF323 ZNF808
HIC2 for paralogs About GeneDecksing
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Genomic Variantsfor HIC2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 22 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for HIC2 (21771693 - 21805752 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 11 variations for HIC2 10 CNVs : 73765 5173 73764 2263 90900 79463 0817 79461 90898 38956 1 Indel : 73762
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing HIC2
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Disorders
/ Diseasesfor HIC2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
HIC2 for disorders About GeneDecksing
OMIM gene information: 607712
OMIM disorders : --3 diseases for HIC2 : About MalaCards systemic lupus erythematosus lupus erythematosus digeorge syndrome Export disorders for HIC2 gene to outside databases
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Publicationsfor HIC2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for HIC2 gene, integrated from 9 sources (see all 20 ): (articles sorted by number of sources associating them with HIC2) Utopia : connect your pdf to the dynamic world of online information
Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PubMed id 11554746) 1 , 2 , 3, 9 Deltour S.... Leprince D. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802) 1 , 2 Collins J.E.... Dunham I. (2004) Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954) 1 , 2 Nakajima D.... Nagase T. (2002) The DNA sequence of human chromosome 22. (PubMed id 10591208) 1 , 2 Dunham I....O'Brien K.P. (1999) Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851) 1 , 2 Kikuno R....Ohara O. (1999) Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118) 1 Woods N.T....Monteiro A.N. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) Genome-wide association study in a Chinese Han popula tion identifies nine new susceptibility loci for systemic lupus erythematosus. (PubMed id 19838193) 1 Han J.W....Zhang X.J. (2009)
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External Searches for HIC2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing HIC2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing HIC2 gene
(According to HUGE )
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Specialized Databases showing HIC2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for HIC2 gene: Search GeneIP for patents involving HIC2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor HIC2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for HIC2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for HIC2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for HIC2 OriGene Protein Over-expression Lysate for HIC2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for HIC2 OriGene 3'-UTR Clone for HIC2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HIC2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HIC2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for HIC2 OriGene Custom Protein Services for HIC2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIC2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing HIC2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat HIC2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat HIC2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat HIC2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat HIC2
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HIC2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC2
Search ThermoFisher Antibodies for HIC2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HIC2
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Aliases for HIC2
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Disorders / Diseases for HIC2
Domains / Families for HIC2
Drugs / Compounds for HIC2
Expression for HIC2
Function for HIC2
Genomic Views for HIC2
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Pathways / Interactions for HIC2
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Transcripts for HIC2
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