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HIC1 Gene

protein-coding   GIFtS: 57

GC17P001906
hypermethylated in cancer 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for HIC1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
Hic-1 3
ZBTB29 1, 2, 3
hic-1 2
Descriptions
Zinc finger and BTB domain-containing protein 29 3
hypermethylated in cancer 1 2
External Ids
HGNC: 49091
Entrez Gene: 30902
UniProtKB: Q145263
Ensembl: ENSG000001773747
Search outside databases for aliases for HIC1 gene

Previous GC identifers: GC17P002266 GC17P002300 GC17P001910 GC17P002166

Summaries
for HIC1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526
Function: Transcriptional repressor. May act as a tumor suppressor. May be involved in development
of head, face, limbs and ventral body wall

Gene Wiki entry for HIC1

Genomic Location
for HIC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HIC1 gene  

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

HIC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P001906:     (about GC identifiers)

Start:
 1,905,143 bp from pter
End:
 1,909,731 bp from pter
Size:
 4,589 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010718.15  

Proteins
for HIC1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526 (See protein sequence)
Recommended Name: Hypermethylated in cancer 1 protein  
Size: 733 amino acids; 76468 Da
Subunit: Interacts with CtBP
Subcellular location: Nucleus
Alternative splicing: 2 isoforms:  Q14526-1   Q14526-2   (Additional isoforms seem to exist)

Post-translational modifications:

  • Acetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT11
  • Sumoylated on Lys-333 by a PIAS family member, which positively regulates transcriptional
    repression ativity and is enhanced by HDAC41
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_001091672.1  NP_006488.2  


    ENSEMBL proteins: 
    ENSP00000382742 ENSP00000314080 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (HIC1)
    Human Recombinant Proteins from Abnova (HIC1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005634 nucleus NAS--
    About this table

    Antibodies for HIC1: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of HIC1
    Sigma-Aldrich Antibodies for HIC1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (HIC1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (HIC1)
    Novus Biologicals Antibodies for HIC1

    Assays for HIC1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for HIC1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like


       GeneDecks  HIC1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q14526

    ProtoNet protein and cluster: Q14526

    2 Blocks protein families:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 C2H2-type zinc fingers

    Gene Function
    for HIC1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (HIC1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HIC1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006497

                  Applied Biosystems Silencer® siRNAs for HIC1

                  Sigma-Aldrich siRNA and siRNA Panels for HIC1  
                         Sigma-Aldrich shRNA Panels and shRNA for HIC1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001098202
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001098202
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001098202 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001098202

    UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526
    Function: Transcriptional repressor. May act as a tumor suppressor. May be involved in development
    of head, face, limbs and ventral body wall

    Genatlas biochemistry entry for HIC1:
    zinc finger transcription factor gene,ubiquitously expressed in mesenchyme of the
    sclerotomes,lateral body wall,limb and craniofacial region,hypermethylated and underexpressed in
    tumor,deleted in the Miller-Dieker syndrome,putatively involved in the pathogenesis as suggested
    by the developmental defects observed in Hic1 deficient mice

    12 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Hic1):

    craniofacialdigestive/alimentaryembryogenesisgrowth/sizehearing/vestibular/ear
    immune systemlethality-prenatal/perinatallimbs/digits/tailnervous systemskeleton
    skin/coat/nailstumorigenesis

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 transcription factor activity TAS7585125
    GO:0005515 protein binding IEA--
    GO:0008270 zinc ion binding IEA--
    GO:0046872 metal ion binding IEA--
    About this table

    Pathways & Interactions
    for HIC1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for HIC1
     Selected targets of p53

       GeneDecks  HIC1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  HIC1 


    5/28 Interacting proteins for HIC1 (ENSP000003140803 Q145262) via UniProtKB, MINT, and/or STRING (see all 28 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF7L2Q9NQB02STRING (score=.727) MINT-2730845 MINT-2730694 MINT-2730765 MINT-2730819 MINT-2730877 MINT-2730798
    CTNNB1P352222STRING (score=.813) MINT-2730948 MINT-2730906
    TP53ENSP000002693053STRING (score=.996)
    CTBP1ENSP000003724113STRING (score=.955)
    CTBP2ENSP000003118253STRING (score=.904)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006355 regulation of transcription, DNA-dependent TAS7585125
    GO:0007275 multicellular organismal development NAS--
    GO:0045786 negative regulation of cell cycle IEA--
    About this table

    Drugs & Compounds
    for HIC1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for HIC1
    2 Novoseek chemical compound relationships for HIC1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 7.87 2 9838134 (1), 16386221 (1)
    lysine 7.51 2 17283066 (2)
    About this table


    Transcripts
    for HIC1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (HIC1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (HIC1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_006497

                  Sigma-Aldrich siRNA and siRNA Panels for HIC1  
                         Sigma-Aldrich shRNA Panels and shRNA for HIC1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001098202  NM_006497  

    REFSEQ mRNAs for HIC1 gene (2 alternative transcripts): 

    NM_001098202.1   NM_006497.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001098202  NM_006497  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001098202
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001098202
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001098202 

    Additional cDNA sequence: 

    AJ583693.1 AJ583694.1 

    4 DOTS entries:

    DT.75183578  DT.97793647  DT.121010887  DT.95155546 

    23 AceView cDNA sequences:

    BX280170 BI768757 AI478432 BF515405 BG099265 AI523046 NM_006497 BC030208 
    AJ583694 AJ583693 AI073751 BI822199 AA910862 AI391567 BU625650 BF057013 
    AJ550616 BE464410 BF940532 AW517436 AA971486 AA991668 BF194704 

    highest scoring ESTs for HIC1:

    AI391567 AA910862 AA971486 AI073751 AI478432 AI523046 AJ550616 AJ583693 AJ583694 BC030208 

    Unigene Clusters for HIC1:

    Hypermethylated in cancer 1
    Hs.72956  [show with all ESTs], Hs.695682
    Unigene Representative Sequences: NM_006497, AJ583693


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000399849  ENST00000322941  

    Expression
    for HIC1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    HIC1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for HIC1

    1 / 2 / 3

    7 probe-sets matching HIC1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		34626_at2, 3 U95-A 1 1.00 1.00 -0.20 0.34 AI391567 1.00 1.00 1.00 1
    86316_at2 U95-E 1 1.00 1.00 0.93 1.20 -- -- -- -- --

    		68478_at2, 3 U95-D 1 1.00 1.00 0.86 0.81 AI478432 0.80 1.00 0.91 1

    		208461_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006497 0.60 1.00 0.82 1

    		230218_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    		208461_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		230218_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  HIC1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.72956 Hs.695682

    UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526
    Tissue specificity: Ubiquitously expressed with highest levels found in lung, colon, prostate,
    thymus, testis and ovary. Expression is absent or decreased in many tumor cells

    Orthologs
    for HIC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for HIC1 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 HIC11   -- hypermethylated in cancer 1 93.26(n)
    96.86(a)    		 491198  XM_548318.2  XP_548318.2 
    chimpanzee
    (Pan troglodytes)    		 HIC11   -- hypermethylated in cancer 1 94(n)
    92.61(a)    		 750446  XM_001174287.1  XP_001174287.1 
    cow
    (Bos taurus)    		 HIC11   -- similar to hypermethylated in cancer 1 90.99(n)
    94.28(a)    		 786191  XM_001253950.1  XP_001253951.1 
    rat
    (Rattus norvegicus)    		 Hic11   -- hypermethylated in cancer 1 87.68(n)
    93.82(a)    		 303310  XM_220706.4  XP_220706.4 
    mouse
    (Mus musculus)    		 Hic11, 5 11 (47.65 cM)5
    		 hypermethylated in cancer 11, 5 88.3(n)1
    95.28(a)1    		 152481  NM_010430.11  NP_034560.11 
     AA4083115  AF0363345  (see all 17)
    About this table        Species with no ortholog for HIC1

    ENSEMBL Gene Tree for HIC1

    Paralogs
    for HIC1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for HIC1 gene
    HIC22  MYNN2  ZBTB52  

    SNPs/Variants
    for HIC1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/19 NCBI SNPs in HIC1 are shown (see all 19 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 37)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs129530351,2
    		C1903474(+) TGAGGA/GGCCTC 1 -- ng510--------
    --
    rs80653501,2
    		C1904347(+) GAGAAA/GAAGTC 1 -- ng51 trp30--------
    --
    rs44550051,2
    		C1905286(+) AGGTGA/GGTCCT 2 -- int1 ng510--------
    rs99018061,2
    		C1906572(+) GCAGCC/TGGTCC 2 -- int10--------
    --
    rs286058021,2
    		--1904071(+) CCCGCC/TCCACG 1 -- ng510--------
    rs10633171,2
    		--1908850(+) ACGGCC/GGGACC 2 R/G mis1 ese31Minor allele frequency- G:0.00MN 184
    rs26414341,2
    		--1903766(+) GCGCAC/GGAAAG 1 -- ng510--------
    --
    rs614537081,2
    		--1904012(+) GCGGTA/GGAGGG 1 -- ng510--------
    --
    rs80658201,2
    		--1904643(+) GATAGA/GGCTGG 2 -- ng51 tfbs30--------
    --
    rs44808461,2
    		--1905367(+) ATCTTC/TTGGCG 2 -- int1 ng510--------
    About this table

    HapMap Linkage Disequilibrium images for HIC1 (up to first 250kb)

    Disorders & Mutations
    for HIC1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 603825

    UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526
  • Defects in HIC1 may be a cause of the facial dysmorphism and additional birth defects
    (except for lissencephaly) seen in the contiguous gene disorder Miller-Dieker syndrome (MDS), like
    defective development of the nose, jaws, extremities, gastrointestinal tract, and kidney

    • 10/15 Novoseek disease relationships for HIC1 gene (see all 15 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    allelic loss 74.41 4 15837543 (2), 9572497 (1), 11073960 (1)
    medulloblastoma 70.32 13 18347096 (5), 14688019 (3), 14656076 (2), 15231840 (1) (see all 5)
    cancer 51.29 39 11747329 (3), 9572497 (2), 17079468 (2), 16386221 (2) (see all 24)
    tumors 45.49 52 11299800 (5), 16386221 (5), 9572497 (3), 17982487 (3) (see all 26)
    microsatellite instability 42.12 1 12773202 (1)
    hepatitis chronic 22.81 1 10051471 (1)
    breast cancer 22.55 18 11747329 (5), 9572497 (4), 15251963 (1), 16641902 (1) (see all 5)
    hepatocellular carcinoma 19.49 2 10051471 (1), 16412291 (1)
    ovarian cancer 17.85 2 16386221 (1), 18757082 (1)
    carcinoma squamous cell 15.98 3 11299800 (2), 11448914 (1)
    About this table

    Medical News
    for HIC1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for HIC1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/63 PubMed articles for HIC1 gene (see all 63 ):

    Search for HIC1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HIC1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 3090 HGNC: 4909 AceView: HIC1 Ensembl:ENSG00000177374 euGenes: HUgn3090
    ECgene: HIC1 H-InvDB: HIC1

    Other Databases showing HIC1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing HIC1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for HIC1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for HIC1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for HIC1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for HIC1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for HIC1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for HIC1 Antibodies for HIC1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for HIC1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for HIC1

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