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HIC1 Gene

protein-coding   GIFtS: 58
GCID: GC17P001973

Hypermethylated In Cancer 1

  See HIC1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hypermethylated In Cancer 11 2     hic-12
Zinc Finger And BTB Domain-Containing Protein 292 3     Hypermethylated In Cancer 1 Protein2
ZBTB292 3     Hic-13
ZNF9012     

External Ids:    HGNC: 49091   Entrez Gene: 30902   Ensembl: ENSG000001773747   OMIM: 6038255   UniProtKB: Q145263   

Export aliases for HIC1 gene to outside databases

Previous GC identifers: GC17P002266 GC17P002300 GC17P001910 GC17P002166 GC17P001906 GC17P001905 GC17P001958 GC17P001964 GC17P001967


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HIC1 Gene:
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of
this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative
splicing of this gene results in multiple transcript variants. (provided by RefSeq, Sep 2010)

GeneCards Summary for HIC1 Gene:
HIC1 (hypermethylated in cancer 1) is a protein-coding gene. Diseases associated with HIC1 include miller-dieker syndrome, and chromosome 17p deletion. GO annotations related to this gene include histone deacetylase binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ZBTB10.

UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526
Function: Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'.
May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall.
Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic
DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as
CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to
involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses
transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of
the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with
promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A,
indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses
transcription from ACKR3, FGFBP1 and EFNA1

Gene Wiki entry for HIC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the HIC1 gene promoter:
         Max   CP2   AP-2beta   AP-4   AP-2alpha   GATA-2   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HIC1 promoter sequence
   Search Chromatin IP Primers for HIC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HIC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

HIC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HIC1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P001973:  view genomic region     (about GC identifiers)

Start:
1,957,448 bp from pter      End:
1,962,981 bp from pter
Size:
5,534 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526 (See protein sequence)
Recommended Name: Hypermethylated in cancer 1 protein  
Size: 733 amino acids; 76508 Da
Subunit: Self-associates. Interacts with HIC2. Interacts with CTBP1 and CTBP2. Interacts with TCF7L2 and ARID1A.
Interacts with MTA1 and MBD3; indicative for an association with the NuRD complex
Miscellaneous: The HIC1 gene is frequently found epigenetically silenced or deleted in different types of solid
tumors
Secondary accessions: D3DTI4
Alternative splicing: 2 isoforms:  Q14526-1   Q14526-2   

Explore the universe of human proteins at neXtProt for HIC1: NX_Q14526

Explore proteomics data for HIC1 at MOPED

Post-translational modifications: 

  • Acetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT11
  • Sumoylated on Lys-333 by a PIAS family member, which enhances interaction with MTA1, positively regulates
    transcriptional repression activity and is enhanced by HDAC41
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HIC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091672.1  NP_006488.2  

    ENSEMBL proteins: 
     ENSP00000461476   ENSP00000476554   ENSP00000460268   ENSP00000382742   ENSP00000467045  
     ENSP00000314080  

    HIC1 Human Recombinant Protein Products:

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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HIC1
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HIC1
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    Novus Biologicals HIC1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HIC1

     
    Search eBioscience for Proteins for HIC1 

    HIC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HIC1
    Novus Biologicals HIC1 Antibodies
    Abcam antibodies for HIC1
    Cloud-Clone Corp. Antibodies for HIC1
    Search ThermoFisher Antibodies for HIC1
    LSBio Antibodies in human, mouse, rat for HIC1

    HIC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HIC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HIC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HIC1
    Cloud-Clone Corp. CLIAs for HIC1
    Search eBioscience for ELISAs for HIC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing
    ZNF: Zinc fingers, C2H2-type

    Selected InterPro protein domains (see all 7):
     IPR028424 HIC1
     IPR000210 BTB/POZ-like
     IPR015880 Znf_C2H2-like
     IPR011333 BTB/POZ_fold
     IPR013087 Znf_C2H2/integrase_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q14526

    ProtoNet protein and cluster: Q14526

    2 Blocks protein domains:
    IPB000210 BTB/POZ domain
    IPB007086 C2H2-type zinc finger signature


    UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526
    Domain: The BTB domain inhibits the binding to a single consensus binding site, but mediates cooperative binding
    to multiple binding sites
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 5 C2H2-type zinc fingers


    Find genes that share domains with HIC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HIC1_HUMAN, Q14526
    Function: Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'.
    May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall.
    Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic
    DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as
    CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to
    involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses
    transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of
    the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with
    promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A,
    indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses
    transcription from ACKR3, FGFBP1 and EFNA1

         Genatlas biochemistry entry for HIC1:
    zinc finger transcription factor gene,ubiquitously expressed in mesenchyme of the sclerotomes,lateral body
    wall,limb and craniofacial region,hypermethylated and underexpressed in tumor,deleted in the Miller-Dieker
    syndrome,putatively involved in the pathogenesis as suggested by the developmental defects observed in Hic1
    deficient mice

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity TAS7585125
    GO:0005515protein binding IPI12052894
    GO:0042826histone deacetylase binding IDA12052894
    GO:0043565sequence-specific DNA binding IDA15231840
         
    Find genes that share ontologies with HIC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HIC1:
     Increased ID2::GFP protein exp 

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hic1):
     craniofacial  digestive/alimentary  embryogenesis  growth/size/body  hearing/vestibular/ear 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     normal  skeleton  tumorigenesis 

    Find genes that share phenotypes with HIC1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hic1tm1.2Kori for HIC1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HIC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HIC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HIC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HIC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HIC1:
    hsa-mir-335-5p (MIRT017725)

    Block miRNA regulation of human, mouse, rat HIC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIC1 (see all 50):
    hsa-miR-328 hsa-miR-300 hsa-let-7d hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-128 hsa-miR-624 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHIC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HIC1
    Predesigned siRNA for gene silencing in human, mouse, rat HIC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HIC1

    Clone
    Products:
         
    OriGene clones in human, mouse for HIC1 (see all 12)
    OriGene ORF clones in mouse, rat for HIC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HIC1 (NM_006497)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIC1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HIC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for HIC1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HIC1_HUMAN, Q14526: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785chromatin ISS--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HIC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HIC1 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of p53
    Selected targets of p53
    2E2F transcription factor network
    E2F transcription factor network
    3Direct p53 effectors
    Direct p53 effectors


    2 BioSystems Pathways for HIC1
        E2F transcription factor network
    Direct p53 effectors


        Pathway & Disease-focused RT2 Profiler PCR Arrays including HIC1: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              Breast Cancer in human mouse rat
              Lymphoma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HIC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HIC1 (Q145261, 2, 3 ENSP000003140804) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARID1AO144971, 3, ENSP000003204854EBI-2507362,EBI-637887 I2D: score=2 STRING: ENSP00000320485
    TCF7L2Q9NQB01, 2, 3, ENSP000003584044EBI-2507362,EBI-924724 MINT-2730845 MINT-2730694 MINT-2730765 MINT-2730819 MINT-2730877 MINT-2730798 I2D: score=2 STRING: ENSP00000358404
    CTNNB1P352222, 3, ENSP000003444564MINT-2730948 MINT-2730906 I2D: score=1 STRING: ENSP00000344456
    CTBP1Q133631, 3, ENSP000002909214EBI-2507362,EBI-908846 I2D: score=2 STRING: ENSP00000290921
    CTBP2P565451, 3, ENSP000003118254EBI-2507362,EBI-741533 I2D: score=2 STRING: ENSP00000311825
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS7585125
    GO:0007275multicellular organismal development IEA--
    GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage IDA16269335

    Find genes that share ontologies with HIC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HIC1

    4 Novoseek inferred chemical compound relationships for HIC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5-aza-2'deoxycytidine 48.3 5 11747329 (1), 14656076 (1)
    zinc 14.1 3 9838134 (1), 19491197 (1), 16386221 (1)
    lysine 4.33 2 17283066 (2)
    cisplatin 0 2 17079468 (1), 15149548 (1)



    Find genes that share compounds with HIC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HIC1 gene (2 alternative transcripts): 
    NM_001098202.1  NM_006497.3  

    Unigene Cluster for HIC1:

    Hypermethylated in cancer 1
    Hs.72956  [show with all ESTs]
    Unigene Representative Sequence: NM_006497
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574370 ENST00000571875 ENST00000571990 ENST00000399849(uc002fty.4 uc002ftz.4)
    ENST00000576444(uc021tnn.1) ENST00000322941(uc010cjy.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat HIC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HIC1 (see all 50):
    hsa-miR-328 hsa-miR-300 hsa-let-7d hsa-miR-513a-5p hsa-miR-218-1* hsa-miR-128 hsa-miR-624 hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidHIC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HIC1
    Clone
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    OriGene ORF clones in mouse, rat for HIC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HIC1 (NM_006497)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HIC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIC1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for HIC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIC1
      QuantiTect SYBR Green Assays in human, mouse, rat HIC1
      QuantiFast Probe-based Assays in human, mouse, rat HIC1

    Additional mRNA sequence: 

    AJ550616.1 BC030208.1 DQ187313.1 

    4 DOTS entries:

    DT.75183578  DT.97793647  DT.121010887  DT.95155546 

    23 AceView cDNA sequences:

    BI768757 BG099265 AI478432 BF515405 NM_006497 BC030208 AI523046 BX280170 
    AI073751 AJ583694 AA910862 BU625650 BI822199 AJ583693 AI391567 BF057013 
    BE464410 AJ550616 AW517436 BF940532 AA971486 AA991668 BF194704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HIC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCCCGGCG
    HIC1 Expression
    About this image


    HIC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
    HIC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HIC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.72956

    UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526
    Tissue specificity: Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis and
    ovary. Expression is absent or decreased in many tumor cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HIC1: 
              Oncogenes & Tumor Suppressor Genes in human mouse rat
              Leukemia in human mouse rat
              Breast Cancer in human mouse rat
              Lymphoma in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HIC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HIC1
    QuantiTect SYBR Green Assays in human, mouse, rat HIC1
    QuantiFast Probe-based Assays in human, mouse, rat HIC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HIC1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hic11 , 5 hypermethylated in cancer 11, 5 88.4(n)1
    95.42(a)1
      11 (45.76 cM)5
    152481  NM_010430.21  NP_034560.21 
     751645655 
    chicken
    (Gallus gallus)
    Aves HIC11 hypermethylated in cancer 1 75.97(n)
    73.05(a)
      396164  NM_205236.1  NP_990567.1 
    lizard
    (Anolis carolinensis)
    Reptilia HIC16
    hypermethylated in cancer 1
    57(a)
    1 ↔ 1
    GL344562.1(18130-20043)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hic11 hypermethylated in cancer 1 65.66(n)
    67.83(a)
      100498001  XM_004911637.1  XP_004911694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hic11 hypermethylated in cancer 1 56.53(n)
    55.29(a)
      436585  NM_001002314.1  NP_001002314.1 


    ENSEMBL Gene Tree for HIC1 (if available)
    TreeFam Gene Tree for HIC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HIC1 gene
    ZBTB102  ZBTB32  ZBTB182  ZBTB8A2  ZBTB442  ZBTB52  ENSG000002545532  ZBTB492  
    ZBTB482  MYNN2  HIC22  ZBTB422  ZBTB462  ZBTB8B2  ZBTB172  
    Selected SIMAP similar genes for HIC1 using alignment to 7 protein entries:     HIC1_HUMAN (see all proteins) (see all similar genes):
    ZBTB7C    ZBTB20    ZBTB4    ZNF295    KLHL36    ZBTB49
    ZBTB38    ZBTB21    BACH2    Bach2    ZBTB8B    ZBTB14
    ZBTB3    BACH1    BCL6    ZBTB25    KLHL28    NACC1

    Find genes that share paralogs with HIC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HIC1 (see all 115)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739761891,2
    C,F--1956677(+) AGAAGA/GACTCC 1 -- us2k12Minor allele frequency- G:0.06WA 120
    rs129530351,2
    C,F,H--1956724(+) TGAGGA/GGCCTC 1 -- us2k117Minor allele frequency- G:0.04NS EA NA CSA 1988
    rs1818065321,2
    C--1956819(+) AGACCC/GGCAGC 1 -- us2k10--------
    rs1484116421,2
    C--1956929(+) CATGG-/GGCGGACTCAGG
    CAGCGGCGGGAATCA
    GGCGG
    1 -- us2k10--------
    rs1124912391,2
    C,F--1957146(+) ACAGCG/ACGGGG 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1135342251,2
    C--1957173(+) GCTAAG/ACTCTC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1864992291,2
    --1957176(+) AAGCTC/TTCCAA 1 -- us2k10--------
    rs614537081,2
    C--1957262(+) GCGGTA/GGAGGG 1 -- us2k10--------
    rs340414821,2
    C,F--1957305(+) GGGGAC/-CCCCC 1 -- us2k12Minor allele frequency- -:0.50NA 4
    rs352657361,2
    C--1957348(+) GTCAGG/AAGGTG 1 -- us2k11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for HIC1 (1957448 - 1962981 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HIC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3035n71CNV Loss21882294
    nsv907523CNV Loss21882294
    esv24096CNV Loss19812545
    nsv907526CNV Loss21882294
    nsv827857CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HIC1
    DNA2.0 Custom Variant and Variant Library Synthesis for HIC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603825    OMIM disorders: --

    7 diseases for HIC1:    
    About MalaCards
    miller-dieker syndrome    chromosome 17p deletion    male germ cell tumor    mantle cell lymphoma
    medulloblastoma    hepatocellular carcinoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HIC1:
    Cancer

    Find genes that share disorders with HIC1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for HIC1 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allelic loss 73.1 4 15837543 (2), 9572497 (1), 11073960 (1)
    medulloblastoma 68.2 13 18347096 (5), 14688019 (3), 14656076 (2), 15231840 (1) (see all 5)
    microsatellite instability 57.4 1 12773202 (1)
    cancer 54.8 49 11747329 (3), 9572497 (2), 17079468 (2), 19822477 (2) (see all 29)
    tumors 47.8 58 11299800 (5), 16386221 (5), 9572497 (3), 17982487 (3) (see all 30)
    hepatocellular carcinoma 23.1 4 19491197 (1), 10051471 (1), 16412291 (1)
    hepatitis chronic 20.2 1 10051471 (1)
    carcinoma squamous cell 19.9 3 11299800 (2), 11448914 (1)
    breast cancer 19 18 11747329 (5), 9572497 (4), 15251963 (1), 16641902 (1) (see all 5)
    cervical cancer 18.1 1 19755648 (1)

    Genetic Association Database (GAD): HIC1
    Human Genome Epidemiology (HuGE) Navigator: HIC1 (4 documents)

    Export disorders for HIC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HIC1 gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with HIC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. (PubMed id 17283066)1, 2, 9 Stankovic-Valentin N.... Leprince D. (Mol. Cell. Biol. 2007)
    2. HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta- catenin to the nuclear bodies. (PubMed id 16724116)1, 2, 9 Valenta T.... Korinek V. (EMBO J. 2006)
    3. A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. (PubMed id 16762039)1, 2, 9 Stankovic-Valentin N.... Leprince D. (FEBS J. 2006)
    4. Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1). (PubMed id 19525223)1, 2, 9 Van Rechem C.... Leprince D. (J. Biol. Chem. 2009)
    5. Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. (PubMed id 10611298)1, 2, 9 Deltour S.... Leprince D. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    6. The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. (PubMed id 15231840)1, 2, 9 Pinte S....Leprince D. (J. Biol. Chem. 2004)
    7. Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PubMed id 11554746)1, 2, 9 Deltour S.... Leprince D. (Biochem. Biophys. Res. Commun. 2001)
    8. Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. (PubMed id 17213307)1, 2, 9 Zhang Q.... Goodman R.H. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    9. p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. (PubMed id 7585125)1, 2, 9 Wales M.M.... Baylin S.B. (Nat. Med. 1995)
    10. Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells. (PubMed id 20547755)1, 2 Van Rechem C.... Leprince D. (Mol. Cell. Biol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3090 HGNC: 4909 AceView: HIC1 Ensembl:ENSG00000177374 euGenes: HUgn3090
    ECgene: HIC1 H-InvDB: HIC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HIC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HIC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HIC1 gene:
    Search GeneIP for patents involving HIC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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