HIC1 Gene
protein-coding GIFtS: 56
GCID: GC17P001964
|
|
hypermethylated in cancer 1
| |
Aliases
for HIC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Hypermethylated In Cancer 11 2 | | Hic-13 | | ZBTB291 2 3 | | Hypermethylated In Cancer 1 Protein2 | | ZNF9011 2 | | Hic-13 | | Zinc Finger And BTB Domain-Containing Protein 292 3 | | |
Export aliases for HIC1 gene to outside databasesPrevious GC identifers: GC17P002266 GC17P002300 GC17P001910 GC17P002166 GC17P001906 GC17P001905 GC17P001958 |
Summaries
for HIC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIC1:
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of thisgene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicingof this gene results in multiple transcript variants. (provided by RefSeq, Sep 2010)
UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526Function: Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Mayact as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved indown-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses.The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. Theregulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1(indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association withTCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to represstranscription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-typechromatin-remodeling complex. Probably represses transcription from CXCR7, FGFBP1 and EFNA1
Gene Wiki entry for HIC1
|
Genomic Views
for HIC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIC1 gene promoter:
Max CP2 AP-2beta AP-4 AP-2alpha GATA-2 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3HIC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P001964: view genomic region
(about GC identifiers)
Start:
|
1,957,448 bp from pter |
End:
|
1,962,981 bp from pter |
Size:
|
5,534 bases |
Orientation:
|
plus strand |
|
Proteins
for HIC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526 (See
protein sequence)Recommended Name: Hypermethylated in cancer 1 protein Size: 733 amino acids; 76508 Da
Subunit: Self-associates. Interacts with HIC2. Interacts with CTBP1 and CTBP2. Interacts with TCF7L2 and ARID1A.Interacts with MTA1 and MBD3; indicative for an association with the NuRD complex
Subcellular location: Nucleus
Miscellaneous: The HIC1 gene is frequently found epigenetically silenced or deleted in different types of solid tumors
Secondary accessions: D3DTI4Alternative splicing: 2 isoforms: Q14526-1 Q14526-2 Explore the universe of human proteins at neXtProt for HIC1: NX_Q14526
Post-translational modifications:
Acetylated on several residues, including Lys-333. Lys-333 is deacetylated by SIRT11
Sumoylated on Lys-333 by a PIAS family member, which enhances interaction with MTA1, positively regulatestranscriptional repression activity and is enhanced by HDAC41
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14526
HIC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001091672.1 NP_006488.2
ENSEMBL proteins: ENSP00000461476 ENSP00000460268 ENSP00000382742 ENSP00000467045 ENSP00000314080
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
HIC1 for ontologies About GeneDecksing
HIC1 Antibody Products:
Assay Products for HIC1: |
Protein
Domains /
Families
for HIC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIC1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q14526ProtoNet protein and cluster: Q14526 2 Blocks protein families: IPB000210 BTB/POZ domain IPB007086 C2H2-type zinc finger signature
UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526Domain: The BTB domain inhibits the binding to a single consensus binding site, but mediates cooperative binding tomultiple binding sitesSimilarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamilySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 5 C2H2-type zinc fingers |
Function
for HIC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526Function: Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Mayact as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved indown-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses.The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. Theregulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1(indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association withTCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to represstranscription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-typechromatin-remodeling complex. Probably represses transcription from CXCR7, FGFBP1 and EFNA1 Genatlas biochemistry entry for HIC1:zinc finger transcription factor gene,ubiquitously expressed in mesenchyme of the sclerotomes,lateral body wall,limband craniofacial region,hypermethylated and underexpressed in tumor,deleted in the Miller-Dieker syndrome,putativelyinvolved in the pathogenesis as suggested by the developmental defects observed in Hic1 deficient mice
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIC1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): HIC1 (NM_006497) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
HIC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for HIC1:
Animal Models:
Mouse knock-out Hic1tm1.2Kori for HIC1
13 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Hic1):
HIC1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HIC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Direct p53 effectors | | | 2 | E2F transcription factor network | | | 3 | Selected targets of p53 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for HIC1
2  BioSystems Pathways for HIC1
HIC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HIC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for HIC1 (Q145261, 2, 3 ENSP000003140804) via UniProtKB, MINT, STRING, and/or I2D (see all 31)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ARID1A | O144971, 3, ENSP000003204854 | EBI-2507362,EBI-637887 I2D:
score=2 STRING: ENSP00000320485 | | TCF7L2 | Q9NQB02, 3, ENSP000003584044 | MINT-2730845 MINT-2730694 MINT-2730765 MINT-2730819 MINT-2730877 MINT-2730798 I2D:
score=2 STRING: ENSP00000358404 | | CTNNB1 | P352222, 3, ENSP000003444564 | MINT-2730948 MINT-2730906 I2D:
score=1 STRING: ENSP00000344456 | | CTBP1 | Q133631, 3, ENSP000002909214 | EBI-2507362,EBI-908846 I2D:
score=2 STRING: ENSP00000290921 | | CTBP2 | P565451, 3, ENSP000003118254 | EBI-2507362,EBI-741533 I2D:
score=2 STRING: ENSP00000311825 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
ISS | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
TAS | 7585125 | | GO:0007275 | multicellular organismal development |
NAS | -- | | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
IDA | 16269335 |
HIC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for HIC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HIC1 for compounds About GeneDecksing
 Browse Tocris compounds for HIC1
4 Novoseek chemical compound relationships for HIC1 gene About this table
Search CenterWatch for drugs/clinical trials and news about HIC1
|
Transcripts
for HIC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIC1 gene (2 alternative transcripts): NM_001098202.1 NM_006497.3 Unigene Clusters for HIC1: Hypermethylated in cancer 1 Hs.72956 [show with all ESTs], Hs.695682 Unigene Representative Sequences: NM_006497, AJ5836936 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000574370 ENST00000571875 ENST00000571990 ENST00000399849(uc002fty.4 uc002ftz.4)
ENST00000576444(uc021tnn.1) ENST00000322941(uc010cjy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIC1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): HIC1 (NM_006497) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIC1 |
Additional cDNA sequence: AJ583693.1 AJ583694.1 4 DOTS entries: DT.75183578 DT.97793647 DT.121010887 DT.95155546 23 AceView cDNA sequences: BI768757 AI478432 BG099265 BF515405 BX280170 AI523046 BC030208 NM_006497 BI822199 AJ583694 BU625650 AI391567 AA910862 AI073751 AJ583693 BF057013 AJ550616 BE464410 AW517436 BF940532 AA971486 AA991668 BF194704
GeneLoc Exon Structure
|
Expression
for HIC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCCCCGGCG
About this image
See HIC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIC1
SOURCE GeneReport for Unigene clusters: Hs.72956 Hs.695682
UniProtKB/Swiss-Prot: HIC1_HUMAN, Q14526Tissue specificity: Ubiquitously expressed with highest levels found in lung, colon, prostate, thymus, testis andovary. Expression is absent or decreased in many tumor cells
SABiosciences Expression via Pathway-Focused PCR Arrays including HIC1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC1 |
Orthologs
for HIC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HIC1 gene from 3/8 species (see all 8) About this table
ENSEMBL Gene Tree for HIC1 (if available)
TreeFam Gene Tree for HIC1 (if available) |
Paralogs
for HIC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIC1 gene
- ZBTB102 ZBTB32 ZBTB182 ZBTB8A2 ENSG000002545532 ZBTB442 ZBTB52 ZBTB492
- ZBTB242 MYNN2 ZBTB422 HIC22 GZF12 ZBTB462 ZBTB8B2 ZBTB172
18/28 SIMAP similar genes for HIC1 using alignment to 6 protein entries: HIC1_HUMAN (see all proteins)
(see all similar genes):ZBTB7C ZBTB20 ZBTB4 ZNF295 KLHL36 ZBTB49
ZBTB38 ZBTB21 BACH2 ZBTB8B ZBTB14 ZBTB3
BACH1 BCL6 ZBTB25 KLHL28 NACC1 KLHL10
HIC1 for paralogs About GeneDecksing
|
Genomic Variants
for HIC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIC1 (1957448 - 1962981 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HIC1
1 CNV: 72769 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIC1 |
|
Disorders
/ Diseases
for HIC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIC1 for disorders About GeneDecksing
OMIM gene information: 603825
OMIM disorders: --
20/35  diseases for HIC1 (see all 35): About MalaCardsmiller-dieker syndrome diffuse large b-cell lymphoma b-cell lymphomas germ cell tumor
testicular germ cell tumor male germ cell tumor mantle cell lymphoma bilateral breast cancer
esophageal squamous cell carcinoma squamous cell carcinoma transitional cell carcinoma malignant mesothelioma
acute myeloid leukemia fanconi's anemia myeloid leukemia lissencephaly
medulloblastoma hepatocellular carcinoma ependymoma breast cancer
1 disease from the University of Copenhagen DISEASES database for HIC1:Cancer 10/16 Novoseek disease relationships for HIC1 gene (see all 16) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| allelic loss |
73.1 |
4 |
15837543 (2), 9572497 (1), 11073960 (1) |
| medulloblastoma |
68.2 |
13 |
18347096 (5), 14688019 (3), 14656076 (2), 15231840 (1) (see all 5) |
| microsatellite instability |
57.4 |
1 |
12773202 (1) |
| cancer |
54.8 |
49 |
11747329 (3), 9572497 (2), 17079468 (2), 19822477 (2) (see all 29) |
| tumors |
47.8 |
58 |
11299800 (5), 16386221 (5), 9572497 (3), 17982487 (3) (see all 30) |
| hepatocellular carcinoma |
23.1 |
4 |
19491197 (1), 10051471 (1), 16412291 (1) |
| hepatitis chronic |
20.2 |
1 |
10051471 (1) |
| carcinoma squamous cell |
19.9 |
3 |
11299800 (2), 11448914 (1) |
| breast cancer |
19 |
18 |
11747329 (5), 9572497 (4), 15251963 (1), 16641902 (1) (see all 5) |
| cervical cancer |
18.1 |
1 |
19755648 (1) |
Human Genome Epidemiology (HuGE) Navigator: HIC1 (4 documents)
Export disorders for HIC1 gene to outside databases
|
Publications
for HIC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIC1 gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with HIC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. (PubMed id 17283066)1, 2, 9 Stankovic-Valentin N.... Leprince D. (2007)
- HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies. (PubMed id 16724116)1, 2, 9 Valenta T....Korinek V. (2006)
- A L225A substitution in the human tumour suppressor HIC1 abolishes its interaction with the corepressor CtBP. (PubMed id 16762039)1, 2, 9 Stankovic-Valentin N....Leprince D. (2006)
- Scavenger chemokine (CXC motif) receptor 7 (CXCR7) is a direct target gene of HIC1 (hypermethylated in cancer 1). (PubMed id 19525223)1, 2, 9 Van Rechem C....Leprince D. (2009)
- Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. (PubMed id 10611298)1, 2, 9 Deltour S....Leprince D. (1999)
- The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence and analysis of its DNA binding and repressive properties. (PubMed id 15231840)1, 2, 9 Pinte S....Leprince D. (2004)
- Characterization of HRG22, a human homologue of the putative tumor suppressor gene HIC1. (PubMed id 11554746)1, 2, 9 Deltour S.... Leprince D. (2001)
- Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. (PubMed id 17213307)1, 2, 9 Zhang Q....Goodman R.H. (2007)
- p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3. (PubMed id 7585125)1, 2, 9 Wales M.M.... Baylin S.B. (1995)
- Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferat ing cells. (PubMed id 20547755)1, 2 Van Rechem C....Leprince D. (2010)
|
External Searches for HIC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for HIC1 gene:
Search GeneIP for patents involving HIC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for HIC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HIC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIC1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIC1 | | OriGene 3'-UTR Clone for HIC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIC1 | | OriGene Custom Protein Services for HIC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIC1 |
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| | | | Search Tocris compounds for HIC1 |
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 | | | HIC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIC1 |
|  |  |  | | | | Search ThermoFisher Antibodies for HIC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIC1 |
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