HIBCH Gene
protein-coding GIFtS: 61
GCID: GC02M191054
|
|
3-hydroxyisobutyryl-CoA hydrolase(Previous name: 3-hydroxyisobutyryl-Coenzyme A hydrolase )
| |
Aliases
for HIBCH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 3-Hydroxyisobutyryl-CoA Hydrolase1 2 | | EC 3.1.2.43 8 | | 3-Hydroxyisobutyryl-Coenzyme A Hydrolase1 2 3 | | 3-Hydroxyisobutyryl-CoA Hydrolase, Mitochondrial2 | | HIBYL-CoA-H2 3 | | HIBYLCOAH2 | | HIB-CoA Hydrolase2 3 | | |
Export aliases for HIBCH gene to outside databasesPrevious GC identifers: GC02M189263 GC02M189772 GC02M191033 GC02M191272 GC02M191271 GC02M190894 GC02M190777 GC02M182929 |
Summaries
for HIBCH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for HIBCH:
This gene encodes the enzyme responsible for hydrolysis of both HIBYL-CoA and beta-hydroxypropionyl-CoA. Mutations inthis gene have been associated with 3-hyroxyisobutyryl-CoA hydrolase deficiency. Alternative splicing results inmultiple transcript variants.(provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: HIBCH_HUMAN, Q6NVY1Function: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA.Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA
|
Genomic Views
for HIBCH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HIBCH gene promoter:
HFH-3 FOXI1 HOXA9 HOXA9B Meis-1 Meis-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for HIBCH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIBCH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.2 Ensembl cytogenetic band: 2q32.2 HGNC cytogenetic band: 2q32.3HIBCH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M191054: view genomic region
(about GC identifiers)
Start:
|
191,054,461 bp from pter |
End:
|
191,208,919 bp from pter |
Size:
|
154,459 bases |
Orientation:
|
minus strand |
|
Proteins
for HIBCH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HIBCH_HUMAN, Q6NVY1 (See
protein sequence)Recommended Name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial precursor Size: 386 amino acids; 43482 Da
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=AAC52114.1; Type=Erroneous initiation; Sequence=AAH05190.2; Type=Erroneous initiation;Sequence=AAY24178.1; Type=Erroneous initiation; Sequence=BAD96699.1; Type=Erroneous initiation; Sequence=BAD96743.1;Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for HIBCH:3BPT (3D)
Secondary accessions: D3DPI4 Q53GA8 Q53GF2 Q53RF7 Q53TC6 Q92931 Q9BS94Alternative splicing: 2 isoforms: Q6NVY1-1 Q6NVY1-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for HIBCH: NX_Q6NVY1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6NVY1
4/7 DME Specific Peptides for HIBCH (Q6NVY1) (see all 7)
HIBCH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_055177.2 NP_932164.1
ENSEMBL proteins: ENSP00000398060 ENSP00000376144 ENSP00000352706 ENSP00000386274 ENSP00000399263 ENSP00000387098 ENSP00000376145 ENSP00000414820 ENSP00000387247 Reactome Protein details: Q6NVY1
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005759 | mitochondrial matrix |
TAS | -- |
HIBCH for ontologies About GeneDecksing
HIBCH Antibody Products:
Assay Products for HIBCH: |
Protein
Domains /
Families
for HIBCH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HIBCH for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6NVY1ProtoNet protein and cluster: Q6NVY1 UniProtKB/Swiss-Prot: HIBCH_HUMAN, Q6NVY1Similarity: Belongs to the enoyl-CoA hydratase/isomerase family |
Function
for HIBCH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HIBCH_HUMAN, Q6NVY1Function: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA.Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoACatalytic activity: 3-hydroxy-2-methylpropanoyl-CoA + H(2)O = CoA + 3-hydroxy-2-methylpropanoateEnzyme Number (IUBMB): EC 3.1.2.41 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIBCH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIBCH (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): HIBCH (NM_198047) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIBCH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIBCH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIBCH |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
-- | -- | | GO:0003860 | 3-hydroxyisobutyryl-CoA hydrolase activity |
IEA | -- |
HIBCH for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for HIBCH:
|
Pathways & Interactions
for HIBCH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Branched-chain amino acid catabolism | | | 2 | Metabolism | | | 3 | Metabolism of amino acids and derivatives | | | 4 | beta-Alanine metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for HIBCH
3 
Reactome Pathways for HIBCH
4 
Kegg Pathways (Kegg details for HIBCH):
UniProtKB/Swiss-Prot: HIBCH_HUMAN, Q6NVY1Pathway: Amino-acid degradation; L-valine degradation
HIBCH for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HIBCH
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/76 Interacting proteins for HIBCH (Q6NVY13 ENSP000003527064) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006574 | valine catabolic process |
IEA | -- | | GO:0009083 | branched-chain amino acid catabolic process |
TAS | -- | | GO:0034641 | cellular nitrogen compound metabolic process |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
HIBCH for ontologies About GeneDecksing
|
Drugs & Compounds
for HIBCH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HIBCH
9 HMDB Compounds for HIBCH About this table
1 DrugBank Compound for HIBCH About this table
Search CenterWatch for drugs/clinical trials and news about HIBCH
|
Transcripts
for HIBCH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HIBCH gene (2 alternative transcripts): NM_014362.3 NM_198047.2 Unigene Cluster for HIBCH: 3-hydroxyisobutyryl-CoA hydrolase Hs.656685 [show with all ESTs]Unigene Representative Sequence: NM_01436214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000399855 ENST00000392332 ENST00000359678(uc002uru.3 uc002urv.3)
ENST00000486981 ENST00000410045 ENST00000416732 ENST00000489147 ENST00000409820
ENST00000392333 ENST00000485992 ENST00000414928 ENST00000409934 ENST00000489269
ENST00000495792
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIBCH (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIBCH (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): HIBCH (NM_198047) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HIBCH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIBCH |
Additional cDNA sequence: AK222979.1 AK223023.1 AK308042.1 AK313651.1 BC005190.1 BC067822.1 U66669.1 21 DOTS entries: DT.99927984 DT.101971560 DT.447680 DT.70100531 DT.40109832 DT.100822031 DT.121008381 DT.75103259 DT.87015635 DT.91931191 DT.92445805 DT.95173987 DT.100647587 DT.100822028 DT.120866786 DT.121008385 DT.91964918 DT.95173994 DT.97773228 DT.97855057 DT.95089894 24/267 AceView cDNA sequences (see all 267): AA383404 CR602055 CR623866 AL520503 AA456847 AA055335 AA829878 CR615079 BQ006495 AA831964 CR598902 BX447433 AA627387 BF446361 AA459668 AK126890 BI491489 BM829786 AA923435 BX484706 AI784606 CR609485 BI753619 BM544619
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for HIBCH About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | | | - | | - | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for HIBCH
|
Expression
for HIBCH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HIBCH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGTGAAAAT
About this image
See HIBCH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HIBCH
SOURCE GeneReport for Unigene cluster: Hs.656685
UniProtKB/Swiss-Prot: HIBCH_HUMAN, Q6NVY1Tissue specificity: Highly expressed in liver and kidney, also detected in heart, muscle and brain (at protein level).Not detected in lung
SABiosciences Expression via Pathway-Focused PCR Array including HIBCH:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIBCH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HIBCH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIBCH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIBCH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIBCH |
Orthologs
for HIBCH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HIBCH gene from 10/33 species (see all 33) About this table
ENSEMBL Gene Tree for HIBCH (if available)
TreeFam Gene Tree for HIBCH (if available) |
Paralogs
for HIBCH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HIBCH gene
HIBCH for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for HIBCH
PGOHUM00000235110
|
Genomic Variants
for HIBCH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HIBCH (191054461 - 191208919 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HIBCH: --
Human Gene Mutation Database (HGMD): HIBCH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIBCH |
|
Disorders
/ Diseases
for HIBCH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HIBCH for disorders About GeneDecksing
OMIM gene information: 610690
OMIM disorders: 250620
UniProtKB/Swiss-Prot: HIBCH_HUMAN, Q6NVY1
Defects in HIBCH are the cause of HIBCH deficiency (HIBCHD) [MIM:250620]; also known as deficiency ofbeta-hydroxyisobutyryl CoA deacylase or methacrylic aciduria. The enzyme defect results in accumulation ofmethacrylyl-CoA, a highly reactive compound, which readily undergoes addition reactions with free sulfhydryl groups.Affected individuals showed delayed development of motor skills, hypotonia, initial poor feeding, and a deteriorationin neurological function during first stages of life
11  diseases for HIBCH: About MalaCards3-hydroxyisobutryl-coa hydrolase deficiency loeys-dietz syndrome ehlers-danlos syndrome hypotonia
liver disease hepatocellular carcinoma neurodegeneration tuberculosis
carcinoma malaria mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for HIBCH:Loeys-Dietz syndrome Human Genome Epidemiology (HuGE) Navigator: HIBCH (2 documents)
Export disorders for HIBCH gene to outside databases
|
Publications
for HIBCH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HIBCH gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with HIBCH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Primary structure and tissue-specific expression of human beta- hydroxyisobutyryl-coenzyme A hydrolase. (PubMed id 8824301)1, 2, 3 Hawes J.W.... Harris R.A. (1996)
- Mutations in the gene encoding 3-hydroxyisobutyryl-CoA hydrolase results in progressive infantile neurodegeneration. (PubMed id 17160907)1, 2 Loupatty F.J.... Wanders R.J.A. (2007)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Proteomic dissection of cell type-specific H2AX-inter acting protein complex associated with hepatocellular carcinoma. (PubMed id 20000738)1 Yang X....Chen X. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
|
External Searches for HIBCH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HIBCH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HIBCH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HIBCH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HIBCH | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for HIBCH gene:
Search GeneIP for patents involving HIBCH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HIBCH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for HIBCH | | OriGene shRNA RFP for HIBCH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HIBCH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HIBCH | | | OriGene Protein Over-expression Lysate for HIBCH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HIBCH | | OriGene 3'-UTR Clone for HIBCH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HIBCH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HIBCH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HIBCH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HIBCH | | OriGene Custom Protein Services for HIBCH | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HIBCH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HIBCH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HIBCH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HIBCH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HIBCH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HIBCH |
| |
 |  |  |  | |
| | | | Search Tocris compounds for HIBCH |
| |  |  |  |  | | | | | | Recombinant Protein for HIBCH |
|
 |
 |
 |
 | | | HIBCH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HIBCH |
|  |  |  | | | | ThermoFisher Antibody for HIBCH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HIBCH |
|
|
|
|
